Normal Simple efficacy of progressive aquatic resistance training for tibiofemoral cartilage in postmenopausal women with mild knee osteoarthritis a randomised controlled trial intensive aquatic resistance training promotes cartilage health quality in knee osteoarthritis self concept predicts academic achievement across levels of the achievement distribution domain specificity for math and reading students self concepts of ability in math reading predict later math reading attainment safety and immunogenicity of the tau vaccine aadvac in patients with alzheimer s disease a randomised double blind placebo controlled phase trial the first in human clinical trial targeting alzheimer s tau protein climate warming reduces the temporal stability of plant community biomass production rising temperatures threaten stability of tibetan alpine grasslands conservation status of north american birds in the face of future climate change many north american birds may lose part of range under climate change scenarios risk factors for overdose in treatment seeking youth with substance use disorders overdose risk factors in youth with substance use disorders metabolic rate and gross efficiency at high work rates in world class and national level sprint skiers going for gold a physiologist s view of champion cross country skiers the transfer of cognitive speed of processing training to older adults driving mobility across years certain type of training can improve driving skills of older adults the clustering of galaxies in the completed sdss iii baryon oscillation spectroscopic survey cosmological analysis of the dr galaxy sample dark energy measured with record breaking map of. million galaxies universal quake statistics from compressed nanocrystals to earthquakes from nanocrystals to earthquakes solid materials share similar failure characteristics the effect of chronic intermittent ethanol exposure on spatial memory in adolescent rats the dissociation of metabolic and cognitive tolerances juveniles build up physical but not mental tolerance for alcohol sex on demand geosocial networking phone apps and risk of sexually transmitted infections among a cross sectional sample of men who have sex with men in los angeles county smartphone apps carry higher infection risk than online dating sites or clubs association of the extent of resection with survival in glioblastoma extent of resection associated with likelihood of survival in glioblastoma philornis downsi diptera muscidae an avian nest parasite invasive to the galapagos islands in mainland ecuador invasive parasitic fly on galapagos islands probably came from mainland ecuador demographic drivers of collapse in an island population of tree swallows getting to the root of long term tree swallow declines melanocortin agonism as a viable strategy to control alveolar bone loss induced by oral infection scientists discover possible new weapon in the fight against gum disease impact of a partial smoke free legislation on myocardial infarction incidence mortality and case fatality in a population based registry the regicor study implementation of smoke free legislation reduces the number of acute myocardial infarctions by percent a lymphatic defect causes ocular hypertension and glaucoma in mice new glaucoma cause discovered leading to eye drops to treat molecular basis of blindness mode of slip and crust mantle interaction at oceanic transform faults silent slip along fault line serves as prelude to big earthquakes research suggests association of maternal diabetes with autism in offspring intrauterine exposure to maternal gestational diabetes linked with risk of autism the earthquake cycle in the san francisco bay region ad earthquakes the next big one for the san francisco bay area may be a cluster of major quakes evidence for a quantum dipole liquid state in an organic quasi two dimensional material evidence for a new property of quantum matter revealed measles vaccination supports millennium development goal increasing coverage and increasing child survival in northern ghana measles vaccine increases child survival beyond protecting against measles incorporation of aurochs into a cattle herd in neolithic europe single event or breeding ? dna find reveals new insights into the history of cattle in europe climate change impacts on bumblebees converge across continents buzz the alarm climate change puts squeeze on bumblebees preventing acute malnutrition among young children in crises a prospective intervention study in niger food supplements plus cash to poor families reduces rates of child malnutrition in niger nonsteroidal anti inflammatory medications are cytostatic against human vestibular schwannomas salicylates a class of non steroidal anti inflammatory drugs stop growth of vestibular schwannomas trpv activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking cyp e mediated redox toxicity new pathways to treat non alcoholic fatty liver disease discovered fish scale derived collagen patch promotes growth of blood and lymphatic vessels in vivo scientists discover fish scale derived collagen effective for healing wounds vaginal progesterone prophylaxis for preterm birth the opptimum study a multicentre randomised double blind trial therapy to stop premature birth safe but ineffective study finds global searches for microalgae and aquatic plants that can eliminate radioactive cesium iodine and strontium from the radio polluted aquatic environment a bioremediation strategy microalgae and aquatic plants can help to decrease radiopollution in the fukushima area generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells from embryonic stem cells a sperm replacement and easier path to genetic modification global burden of disease study trends for canada from to people in canada have good health are living longer global burden of disease study trends an ocular commensal protects from corneal infection by driving an il response from mucosal gd t cells eye microbiome trains immune cells to fend off pathogens in mice ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with huntington disease stage and decrease following brain huntingtin suppression new test measures effectiveness of treatments for huntington s disease cocinar para su salud ! randomized controlled trial of a culturally based dietary intervention among hispanic breast cancer survivors nutrition intervention leads to dietary behavior changes in latina breast cancer survivors association of psychological disorders with day readmission rates in patients with chronic obstructive pulmonary disease copd patients with psychological conditions have higher rate of early hospital readmission influence of race on microsatellite instability and cd t cell infiltration in colon cancer racial disparity in colon cancer new study sheds light small cell lung cancer recruitment of macrophages by circulating tumor cells circulating small cell lung cancer cells successfully cultivated for the very first time longitudinal profiles of adaptive behavior in fragile x syndrome socialization relative strength in fragile x longitudinal study histone h depletion impairs embryonic stem cell differentiation successful stem cell differentiation requires dna compaction study finds the quality and impact of risk factor control in patients with stable claudication presenting for peripheral vascular interventions lifestyle changes linked to better outcomes after peripheral intervention aspirin in patients with previous percutaneous coronary intervention undergoing noncardiac surgery aspirin can prevent heart attacks after noncardiac surgery in patients with prior pci randomized controlled trial of cognitive behavioral therapy vs standard treatment to prevent recurrent cardiovascular events in patients with coronary heart disease secondary prevention in uppsala primary health care project suprim stress management program helps prevent heart events in patients with heart disease eutrophication will increase methane emissions from lakes and impoundments during the st century eutrophication of lakes will significantly increase greenhouse gas emissions two new deep reef basslets teleostei grammatidae lipogramma with comments on the eco evolutionary relationships of the genus fishy caribbean juveniles to be recognized as a new species the hourglass basslet effects of targeted delivery of propionate to the human colon on appetite regulation body weight maintenance and adiposity in overweight adults boosting chemical by product of dietary fiber fermentation in gut slims and trims macroalgal terpenes function as allelopathic agents against reef corals chemical warfare on the reef molecules used by certain seaweed to harm corals intergenerational effects of parents math anxiety on children s math achievement and anxiety parents math anxiety can undermine children s math achievement oral administration of nano emulsion curcumin in mice suppresses inflammatory induced nf b signaling and macrophage migration new research adds spice to curcumin s health promoting benefits prevalence of abuse and intimate partner violence surgical evaluation praise in orthopaedic fracture clinics a multinational study domestic violence more common among orthopedic trauma patients than surgeons think a small molecule screen in stem cell derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for als big boost in drug discovery new use for stem cells identifies a promising way to target als changes in marital quality over years and its association with cardiovascular disease risk factors in men findings from the alspac prospective cohort study risk factors for heart health linked to marital ups and downs at least for men timing anthropogenic stressors to mitigate their impact on marine ecosystem resilience saving seagrasses from dredging as new research finds solutions applying d texture algorithms on mri to evaluate quality traits of loin resonances to taste loins and hams without opening them trunk neural crest origin of dermal denticles in a cartilaginous fish growing teeth and a backbone studies trace early origins of skeletal tissues a long term survey of spring monarch butterflies in north central florida florida monarch butterfly populations have dropped percent since cumulative early life adversity predicts longevity in wild baboons rough childhoods have ripple effects for wild baboons slow delivery immunization enhances hiv neutralizing antibody and germinal center responses via modulation of immunodominance new hiv vaccine strategy pumps the immune system using fuzzy logic to determine the vulnerability of marine species to climate change some marine species more vulnerable to climate change than others effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis a randomized clinical trial injected drug reduces risk of fracture among women with osteoporosis clonal level lineage commitment pathways of hematopoietic stem cells in vivo stem cell study offers clues for optimizing bone marrow transplants and more macroalgae decrease growth and alter microbial community structure of the reef building coral porites astreoides the slippery slope to slime overgrown algae causing coral reef declines the burden of acute traumatic spinal cord injury among adults in the united states an update traumatic spinal cord injuries on the rise in u.s. a plant homolog of animal glutamate receptors is an ion channel gated by multiple hydrophobic amino acids new kind of signalling mechanism in plant cells discovered early life antibiotic driven changes in microbiota enhance susceptibility to allergic asthma antibiotic treatment increases the severity of asthma in young mice on chip wavelength multiplexed detection of cancer dna biomarkers in blood laboratory on a chip technique simplifies detection of cancer dna biomarkers even low alcohol concentrations affect obstacle avoidance reactions in healthy senior individuals just two drinks slow reactions in older people research shows a composite measure of personal financial burden among patients with stage iii colorectal cancer of colorectal cancer patients report financial burden from treatment study finds association between early life exposure to air pollution and working memory and attention exposure to air pollution before and after birth may affect fundamental cognitive abilities an exploration of anger phenomenology in multiple sclerosis high unexpressed anger in multiple sclerosis patients linked to nervous system damage not disease severity counting black holes the cosmic stellar remnant population and implications for ligo black holes pervade the universe celestial census indicates rip kinase dependent necrosis drives lethal systemic inflammatory response syndrome targeted blocking of cell death prevents fatal condition septic shock study suggests neuroinflammation of the spinal cord and nerve roots in chronic radicular pain patients neuroinflammation seen in spinal cord nerve roots of patients with chronic sciatica a longitudinal study of indoor nitrogen dioxide levels and respiratory symptoms in inner city children with asthma noxious gas stove emissions worsen asthma symptoms in young children measles resurgence in the usa how international travel compounds vaccine resistance new analysis predicts top u.s. counties at risk for measles outbreaks genomic analysis identifies frequent deletions of dystrophin in olfactory neuroblastoma muscle gene mutations implicated in human nasal sinus cancer resveratrol post transcriptionally regulates pro inflammatory gene expression via regulation of ksrp rna binding activity natural substance in red wine has an anti inflammatory effect in cardiovascular diseases diversity of plant nutrient acquisition strategies increases during long term ecosystem development necessity at the roots of innovation the scramble for nutrients intensifies as soils age vaccine induced hiv seropositivity reactivity in noninfected hiv vaccine recipients hiv vaccines may induce hiv antibodies in trial participants can cause false positive test result yoga treatment for chronic non specific low back pain yoga may have health benefits for people with chronic non specific lower back pain nicotine dependence phenotype time to first cigarette and risk of head and neck cancer early morning smokers have increased risk of lung and head and neck cancers study finds proactive therapeutic concentration monitoring of infliximab may improve outcomes for patients with inflammatory bowel disease proactive monitoring of inflammatory bowel disease therapy could prolong effectiveness emergence of fatal avian influenza in new england harbor seals an avian flu that jumps from birds to mammals is killing new england s baby seals the impact of green tea polyphenols on development and reproduction in drosophila melanogaster green tea impairs development reproduction in fruit flies study finds a literal elytral rainbow tunable structural colors using single diamond biophotonic crystals in pachyrrhynchus congestus weevils new color generation mechanism discovered in rainbow weevil updated estimation of the impact of a japanese encephalitis immunization program with live attenuated sa vaccine in nepal japanese encephalitis vaccine cuts disease rate in nepal fetal sex is associated with maternal stimulated cytokine production but not serum cytokine levels in human pregnancy baby s sex plays a role in pregnant woman s immunity trends in adherence to recommended cancer screening the us population and working cancer survivors us cancer screening rates decline over the last years finds new study the university experiences of students with learning disabilities financial status affects success of students with learning disabilities treatment of men for low testosterone a systematic review study questions benefits of testosterone replacement for low t continuous ultrasound guided adductor canal block for total knee arthroplasty path to better pain control for orthopedic patients discovered air advances in respiration music therapy in the treatment of chronic pulmonary disease music therapy increases effectiveness of pulmonary rehabilitation for copd patients liver transplantation in defects of cholesterol biosynthesis the case of lathosterolosis liver transplant may arrest neurological damage in rare progressive form of autism hippocampal spike timing correlations lead to hexagonal grid fields spatial orientation new model for the origin of grid cells nanoconfined sheets mechanically reinforce the supra biomolecular network of robust squid sucker ring teeth squid sucker ring teeth material could aid reconstructive surgery serve as eco packaging snow cover is a neglected driver of arctic biodiversity loss changes in snow coverage threatens biodiversity of arctic nature the role of chronic and perioperative glucose management in high risk surgical closures high blood sugar levels linked to increased wound complications after surgery stromal cell derived factor mediates cell survival through enhancing autophagy in bone marrow derived mesenchymal stem cells signaling molecule may help stem cells focus on making bone despite age disease internet s dirty secret assessing the impact of online intermediaries on hiv transmission craigslist personals hiv trends entry of site in a community tied to percent increase in hiv evaluating mating compatibility within fruit fly cryptic species complexes and the potential role of sex pheromones in pre mating isolation cage the fly walk in field cages to assess mating compatibility in pest fruit flies neutralizing antibodies generated during natural hiv infection good news for an hiv vaccine ? new strategy proposed for designing antibody based hiv vaccine sex specific glioma genome wide association study identifies new risk locus at p. in females and finds sex differences in risk at q. men and women have different genetic risk factors for developing brain cancer non invasive placental perfusion imaging in pregnancies complicated by fetal heart disease using velocity selective arterial spin labeled mri advanced mri can detect placental perfusion abnormalities in pregnancies complicated by fetal chd acoustic insights into the zooplankton dynamics of the eastern weddell sea daily up and down of the plankton animals in the sea probing dark matter with star clusters a dark matter core in the ultra faint dwarf eridanus ii hunting for dark matter in the smallest galaxies in the universe developing the geriatric injury documentation tool geri idt to improve documentation of physical findings in injured older adults new tool for documenting injuries may provide better evidence for elder abuse cases high proportion of cd b cells in infants predicts development of allergic disease children on dairy farms run one tenth the risk of developing allergies dairy farm exposure also beneficial during pregnancy an internet delivered handwashing intervention to modify influenza like illness and respiratory infection transmission primit a primary care randomised trial internet program to encourage handwashing reduces spread of cold flu viruses water walking as a new mode of free surface skipping water walking the new mode of rock skipping using external reference pricing in medicare part d to reduce drug price differentials with other countries external reference drug pricing could save medicare tens of billions in state tuition for the undocumented education effects on mexican young adults providing in state tuition to undocumented immigrants increases college enrollment brain volumetric correlates of memory in early parkinson s disease changes in brain gray matter volume associated with memory deficits in early parkinson s disease astrocyte specific disruption of syncam signaling results in adhd like behavioral manifestations new animal model for one of the least understood medical issues adhd asteroseismic detection of latitudinal differential rotation in sun like stars astrophysicists measure precise rotation pattern of sun like stars for the first time allogeneic bk virus specific t cells for progressive multifocal leukoencephalopathy cancer patients with rare deadly brain infection treated successfully with off the shelf adoptive t cell therapy a cross sectional analysis of chikungunya arthritis patients months post infection demonstrate no detectable viral persistence in synovial fluid new insights on mosquito borne chikungunya virus infection human immunodeficiency virus infection of human astrocytes disrupts blood brain barrier integrity by a gap junction dependent mechanism solving the puzzle of cognitive problems caused by hiv infection interspecific variation in conspecific negative density dependence can make species less likely to coexist why are tropical forests so diverse ? new study examines role of natural enemies probing the in situ elastic nonlinearity of rocks with earth tides and seismic noise sun moon and sea as part of a seismic probe late quaternary fossil mammals from the cayman islands west indies ancient mammal remains digested by crocodiles reveal new species associations of smoke free policies in restaurants bars and workplaces with blood pressure changes in the cardia study smoke free policies associated with lower blood pressure large scale cognitive gwas meta analysis reveals tissue specific neural expression and potential nootropic drug targets new genetic variations linked to educational attainment genetic overlap between cognitive ability and longevity functional electrical stimulation therapy of voluntary grasping versus only conventional rehabilitation for patients with subacute incomplete tetraplegia a randomized clinical trial benefits of electrical stimulation therapy found with people paralyzed by spinal cord injury conducting unlinked anonymous hiv surveillance in developing countries ethical epidemiological and public health concerns developing countries need support to ethically conduct unlinked anonymous hiv testing clinical characteristics associated with adverse events in patients with exacerbation of chronic obstructive pulmonary disease a prospective cohort study ottawa copd risk scale new tool to identify patients at risk of adverse events death restoring the sense of touch with a prosthetic hand through a brain interface a blueprint for restoring touch with a prosthetic hand ischemic heart disease is associated with lower cortical volumetric bone mineral density of distal radius osteoporosis linked with heart disease in older people neural tube defects in mice with reduced levels of inositol triphosphate kinase some neural tube defects in mice linked to enzyme deficiency planned repeat cesarean section at term and adverse childhood health outcomes a record linkage study planned repeat c section not linked to worse child health than vaginal birth after c s impact of snow darkening by deposition of light absorbing aerosols on snow cover in the himalayas tibetan plateau and influence on the asian summer monsoon a possible mechanism for the blanford hypothesis middle eastern desert dust on the tibetan plateau could affect the indian summer monsoon whole genome sequencing in patients with retinitis pigmentosa reveals pathogenic dna structural changes and nek as a new disease gene whole dna sequencing reveals mutations new gene for blinding disease pregnancy associated death in utah contribution of drug induced deaths opioids leading cause of pregnancy related death in new utah moms reduced risks of neural tube defects and orofacial clefts with higher diet quality overall quality of pregnant woman s diet affects risk for two birth defects study shows a functional genomics predictive network model identifies regulators of inflammatory bowel disease scientists construct first predictive model of inflammatory bowel disease ngm for treatment of non alcoholic steatohepatitis a multicentre randomised double blind placebo controlled phase trial gastrointestinal hormone measurably improved symptoms of non alcoholic fatty liver disease genomic insights into salt adaptation in a desert poplar scientists reveal the genomic enigma of desert poplar associations of electronic cigarette nicotine concentration with subsequent cigarette smoking and vaping levels in adolescents are e cigarettes with higher nicotine associated with more smoking vaping ? accretion of water in carbonaceous chondrites current evidence and implications for the delivery of water to early earth carbonaceous chondrites provide clues about the delivery of water to earth national and local influenza surveillance through twitter an analysis of the influenza epidemic when the flu bug bit the big apple twitter posts told the tale the human pk histo blood group antigen provides protection against hiv infection potential new weapon in battle against hiv infection identified major vault protein a candidate gene in p. microdeletion syndrome is required for the homeostatic regulation of visual cortical plasticity role of specific gene in p. deletion autism obesity increases airway smooth muscle responses to contractile agonists. obesity alters airway muscle function increases asthma risk anti hiv igm protects against mucosal shiv transmission promising new class of antibodies protects against hiv infection prame as an independent biomarker for metastasis in uveal melanoma new biomarker identifies uveal melanoma patients at high risk for metastasis first do no harm are disability assessments associated with adverse trends in mental health ? a longitudinal ecological study tougher disability benefit assessment may have taken serious toll on mental health elicitation of robust tier neutralizing antibody responses in non human primates by hiv envelope trimer immunization using optimized approaches best delivery mode for potential hiv vaccine tested a new baby oviraptorid dinosaur dinosauria theropoda from the upper cretaceous nemegt formation of mongolia fossils of new oviraptorosaur species discovered in mongolia major agricultural changes required to mitigate phosphorus losses under climate change dramatic changes needed in farming practices to keep pace with climate change functional organization of excitatory synaptic strength in primary visual cortex the brain s social network nerve cells interact like friends on facebook patterns of genomic variation in the opportunistic pathogen candida glabrata suggest the existence of mating and a secondary association with humans genetic study uncovers fungal sex secrets which shed light on candidiasis brain somatic mutations in mtor cause focal cortical dysplasia type ii leading to intractable epilepsy mutations taking place only in brain identified as cause of intractable epilepsy evidence of preserved collagen in an early jurassic sauropodomorph dinosaur revealed by synchrotron ftir microspectroscopy good ribbance dinosaur rib bones reveal remnants of million year old protein cognitive function and other risk factors for mild traumatic brain injury in young men nationwide cohort study low cognitive score and risk of brain injury linked do the mental health consequences of sexual victimization differ between males and females ? a general strain theory approach sexism in sexual assault research but this time men are the target media influences on social outcomes the impact of mtv s and pregnant on teen childbearing new study finds mtv s and pregnant teen mom contributed to record decline in u.s. teen childbearing rate extinction risk and conservation of the earth s national animal symbols increased protection of world s national animal symbols needed suggests study the siren s song exploitation of female flight tones to passively capture male aedes aegypti diptera culicidae male mosquitoes lured to traps by sounds of female wing beats genomic risk for severe canine compulsive disorder a dog model of human ocd newly found genomic causes of severe compulsiveness in dogs could aid study of human ocd the origin of the moon within a terrestrial synestia the moon formed inside a vaporized earth synestia a new species of troodontid theropod dinosauria maniraptora from the horseshoe canyon formation maastrichtian of alberta canada new species of dinosaur named after canadian icon high risk staphylococcus aureus transmission in the operating room a call for widespread improvements in perioperative hand hygiene and patient decolonization practices improve hand hygiene and patient decolonization to help stem high risk s. aureus transmission in the operating room insights into the timing intensity and natural setting of neanderthal occupation from the geoarchaeological study of combustion structures a micromorphological and biomarker investigation of el salt unit xb alcoy spain modern analysis of ancient hearths reveals neanderthal settlement patterns diagnosis and management of duchenne muscular dystrophy part respiratory cardiac bone health and orthopaedic management patients living longer with duchenne muscular dystrophy pose new challenge for caregivers ocean acidification can mediate biodiversity shifts by changing biogenic habitat ocean acidification study offers warnings for marine life habitats complementary use of tai chi chih augments escitalopram treatment of geriatric depression tai chi beats back depression in the elderly study shows effects of composites containing bioactive glasses on demineralized dentin new dental materials developed with bioactive glass doped with fluoride to stop degradation of demineralized dentin and evoke remineralization seed production viability and reproductive limits of the invasive ailanthus altissima tree of heaven within invaded environments tree of heaven s prolific seed production adds to its invasive potential ataxin intermediate length polyglutamine expansions are associated with increased risk for als new genetic risk factor for lou gehrig s disease identified a case of post traumatic minimally conscious state reversed by midazolam clinical aspects and neurophysiological correlates patient awakes from post traumatic minimally conscious state after administration of depressant drug the transcriptome of the bermuda fireworm odontosyllis enopla annelida syllidae a unique luciferase gene family and putative epitoky related genes study illuminates genes behind beautiful glow of bermuda fireworms analysis of factors contributing to the low survival of cervical cancer patients undergoing radiotherapy in kenya scientists call for action to tackle cervical cancer in kenya cannabinoid action induces autophagy mediated cell death through stimulation of er stress in human glioma cells active component of marijuana has anti cancer effects study suggests immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer new approach to immunotherapy leads to complete response in breast cancer patient unresponsive to other treatments burst mode pumping a new mechanism of drinking in mosquitoes discovered mode of drinking in mosquitoes carries biomedical implications small mammal diversity loss in response to late pleistocene climatic change small mammals and rest of food chain at greater risk from global warming than thought research finds permeabilization of the blood brain barrier via mucosal engrafting implications for drug delivery to the brain nasal lining used to breach blood brain barrier ethanolamine phosphotransferase selenoprotein i is critical for the neural development and maintenance of plasmalogen in human from haifa to tokyo medical detectives team up on selenoprotein ept ubiquitin facilitates a quality control pathway that removes damaged chloroplasts basic understanding of plants cellular damage control system helps plants tough it out dendrimers as synthetic gene vectors cell membrane attachment first large scale computer simulation of gene therapy gender and genotype modulation of the association between lipid levels and depressive symptomatology in community dwelling elderly the esprit study new links between cholesterol and depression in the elderly adaptive fluid infused porous films with tunable transparency and wettability cry me a river of possibility scientists design new adaptive material inspired by tears obesity and late age survival without major disease or disability in older women obese older women at higher risk for death disease disability before age body mass index waist circumference physical activity and risk of hearing loss in women obesity associated with higher risk of hearing loss in women transgenic expression of the dicotyledonous pattern recognition receptor efr in rice leads to ligand dependent activation of defense responses rice can borrow stronger immunity from other plant species study shows autologous hematopoietic cell transplantation for hiv related lymphoma results of the bmt ctn amc trial autologous stem cell transplant should be standard care for hiv associated lymphoma extended gamma ray sources around pulsars constrain the origin of the positron flux at earth on the origins of star stuff shedding new light on origin of anti matter upper gastrointestinal symptoms psychosocial co morbidity and health care seeking in general practice population based case control study care seeking behavior associated with upper gi symptoms effects of in game virtual direct experience vde on reactions to real world brands player s performance in video games can steer attitudes about brands first direct evidence of long distance seasonal movements and hibernation in a migratory bat caught napping first direct evidence of migratory hoary bats hibernating neuropathological and transcriptomic characteristics of the aged brain new details on aged brain alzheimer s and dementia association between new jersey s graduated driver licensing decal provision and crash rates of young drivers with learners permits figure license plate decals don t seem to curb learner driver crash rates direct reprogramming of mouse fibroblasts toward leydig like cells by defined factors stem cell strategy for boosting testosterone levels tested in rodents calorie restriction protects against experimental abdominal aortic aneurysms in mice consuming fewer calories reduces the risk of abdominal aortic aneurysm study suggests are autism spectrum conditions more prevalent in an information technology region ? a school based study of three regions in the netherlands diagnosed autism is more common in an it rich region study finds secondhand smoke exposure among community dwelling adult cancer survivors in the united states secondhand smoke exposure among nonsmoking adult cancer survivors has declined orogenic wedge deformation and potential for great earthquakes in the central andean backarc does the central andean backarc have the potential for a great earthquake ? self assembly of temperature responsive protein polymer bioconjugates protein conjugation method offers new possibilities for biomaterials the mitochondrial encoded peptide mots c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress mighty mitochondria flex their dna power to help nucleus run the cell children living with hiv infected adults estimates for countries in sub saharan africa little known about children living with hiv infected adults in africa levetiracetam in the management of feline audiogenic reflex seizures a randomised controlled open label study levetiracetam shows promise for treatment of feline audiogenic reflex seizures tracing textile cultures of italy and greece in the early first millennium bc ancient textiles reveal differences in mediterranean fabrics in the st millennium bc an update of the impact of deep brain stimulation on non motor symptoms in parkinson s disease deep brain stimulation improves non motor symptoms in parkinson s disease as well as motor symptoms enzymatically enhanced collisions on ultramicroelectrodes for specific and rapid detection of individual viruses making virus sensors cheap and simple new method detects single viruses in urine a miniature multi contrast microscope for functional imaging in freely behaving animals mini microscope for studies of brain disease in living mice preschool to kindergarten transition patterns for african american boys parenting plays key role when african american boys move from preschool to kindergarten neuromuscular strain increases symptom intensity in chronic fatigue syndrome chronic fatigue syndrome flare ups caused by straining muscles and nerves artificial sweeteners induce glucose intolerance by altering the gut microbiota certain gut bacteria may induce metabolic changes following exposure to artificial sweeteners drying of indian subcontinent by rapid indian ocean warming and a weakening land sea thermal gradient asian monsoon season weakens as the indian ocean warms loss of hydroxymethylcytosine is an epigenetic hallmark of melanoma missing pieces of dna structure is a red flag for deadly skin cancer genomic characterization of brain metastases reveals branched evolution and potential therapeutic targets liquid biopsy of cerebrospinal fluid for more effective policing of brain tumors systemic translocation of staphylococcus drives autoantibody production in hiv disease evidence for link between leaky gut and autoantibody production in hiv positive patients fish and hydropower on the u.s. atlantic coast failed fisheries policies from half way technologies fish journeying upstream are hampered by hydropower dams facilities in northeastern u.s. fail to allow passage of migrating fish real time quantitative pcr measurements of fecal indicator bacteria and human associated source tracking markers in a texas river following hurricane harvey fecal bacteria contaminated surface water after hurricane harvey spider web glue two proteins expressed from opposite strands of the same dna sequence spider web glue spins society toward new biobased adhesives speaking of food connecting basic and applied plant science building a bridge from basic botany to applied agriculture association of opioid agonist therapy with lower incidence of hepatitis c virus infection in young adult injection drug users maintenance therapy for injection drug users associated with lower incidence of hepatitis c highly transparent nonvolatile resistive memory devices from silicon oxide and graphene thanks for the transparent memories progress in quest for reliable flexible computer memory for transparent electronics a high resolution seismic chirp investigation of active normal faulting across the lake tahoe basin california nevada lake tahoe region in u.s. may be due for major earthquake the role of pain in head and neck cancer recurrence and survivorship post treatment pain in head and neck cancer patients linked to recurrence lower survival rate genome wide association study identifies three novel loci in fuchs endothelial corneal dystrophy new genetic links underlying progressively blinding eye disease identified association between the seasonal influenza vaccine and pandemic h n illness during spring summer four observational studies from canada did seasonal flu vaccination increase the risk of infection with pandemic h n flu ? adipocyte gr inhibits healthy adipose expansion through multiple mechanisms in cushing syndrome adipocyte glucocorticoid receptors play a role in developing steroid diabetes group acupuncture for knee pain evaluation of a cost saving initiative in the health service acupuncture offers low cost alternative to knee surgery for osteoarthritis research finds higher education and economic development the importance of building technological capabilities geography skills local companies affect higher education impact on economic development dendritic cell vaccines based on immunogenic cell death elicit danger signals and t cell driven rejection of high grade glioma next generation immunotherapy offers new hope for beating brain cancer two year olds with autism fail to orient toward human biological motion but attend instead to non social physical contingencies autism skews developing brain with synchronous motion and sound quaternary rupture of a crustal fault beneath victoria british columbia canada seismicity in british columbia and hidden continent called zealandia novel recurrently mutated genes in african american colon cancers new gene mutations linked to colorectal cancer found in african american patients human papillomavirus type dna load and year cumulative diagnoses of cervical intraepithelial neoplasia grades hpv dna levels are not prognostic for precancerous cervical lesions brief periods of inactivity reduce leg microvascular but not macrovascular function in healthy young men simple leg exercises could reduce impact of sedentary lifestyle on heart and blood vessels parent child attitude congruence on type and intensity of physical activity testing multiple mediators of sedentary behavior in older children parents endorsement of vigorous team sports increases children s physical activity angular momentum flow during ultrafast demagnetization of a ferrimagnet laser driven spin dynamics in ferrimagnets how does the angular momentum flow ? humans but not deep neural networks often miss giant targets in scenes in plain sight researchers compare the performance of human subjects versus deep neural networks in visual searches tamoxifen provides structural and functional rescue in murine models of photoreceptor degeneration breast cancer drug dampens immune response protecting light sensing cells of the eye a quantitative framework for whole body coordination reveals specific deficits in freely walking ataxic mice locomouse innovative tool sheds light on motor deficits vaccination by microneedle patch with inactivated respiratory syncytial virus and monophosphoryl lipid a enhances the protective efficacy and diminishes inflammatory disease after challenge vaccine using microneedle patch with rsv virus immune stimulating compound is effective against rsv economy of arm autotomy in the mesopelagic squid octopoteuthis deletron deep sea squid can jettison arms as defensive tactic rates of opioid misuse abuse and addiction in chronic pain rate of opioid misuse is around percent addiction rate percent reports study effect of time spent outdoors at school on the development of myopia among children in china additional time spent outdoors by children results in decreased rate of nearsightedness a cucurbit androecy gene reveals how unisexual flowers develop and dioecy emerges battle of the sexes how inhibition of male flower production lets female flowers emerge bacterial peptidoglycan triggers candida albicans hyphal growth by directly activating the adenylyl cyclase cyr p virulence factor that induces fatal candida infection identified virologic effects of broadly neutralizing antibody vrc administration during chronic hiv infection guarding against immune responses limiting efficacy of antibody based approaches to hiv cancer risk in patients with rheumatoid arthritis treated with anti u tumor necrosis factor a therapies anti tumor necrosis factor treatment does not increase cancer risk in rheumatoid arthritis patients study finds tie mediated signal from apoptotic cells protects stem cells in drosophila melanogaster dying cells can protect their stem cells from destruction phase i clinical trial of nintedanib plus paclitaxel in early her negative breast cancer cnio br geicam study first clinical trial on her negative breast cancer with nintedanib shows promising results cabozantinib xl inhibits growth and invasion of preclinical tnbc models potential new therapy for triple negative breast cancer shows promise in lab studies epidermal notch loss promotes skin tumorigenesis by impacting the stromal microenvironment mice with skin condition help scientists understand tumor growth late recruitment of synapsin to nascent synapses is regulated by cdk first steps of synapse building is captured in live zebra fish embryos age cost benefit analysis of the child parent center early education program early childhood education program yields high economic returns goss s wilt incidence in sweet corn is independent of transgenic traits and glyphosate transgenic sweet corn no more susceptible to goss s wilt disease feasibility of wearable physical activity monitors in patients with cancer wearable fitness monitors useful in cancer treatment study finds first structure of full length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer solved protein structure holds key to much needed therapies for metabolic disorder detection of blast related traumatic brain injury in u.s. military personnel blast related injuries detected in the brains of us military personnel climate change upends selection on ornamentation in a wild bird climate change altered the natural selection large forehead patch no longer a winner overlooked trends in observed global annual precipitation reveal underestimated risks overlooked trends in annual precipitation reveal underestimated risks worldwide cohort analysis of a pharmacokinetic modeled methadone weaning optimization for neonatal abstinence syndrome computer based modeling improves outcomes for infants in drug withdrawal mortality in elderly patients operated for an acute subdural hematoma a surgical case series even the elderly can recover from a severe traumatic brain injury vaccine protection against acquisition of neutralization resistant siv challenges in rhesus monkeys experimental vaccine partially protects monkeys from hiv like infection transformation between meron and skyrmion topological spin textures in a chiral magnet first observation of a square lattice of merons and antimerons vitamin d nutritional policy needs a vision for the future biochemist proposes worldwide policy change to step up daily vitamin d intake excess of genomic defects in a woolly mammoth on wrangel island woolly mammoths experienced a genomic meltdown just before extinction expression of the multiple sclerosis associated mhc class ii allele hla drb is regulated by vitamin d genetic study shows direct link between vitamin d and ms susceptibility gene neural substrates of interactive musical improvisation an fmri study of trading fours in jazz the musical brain novel study of jazz players shows common brain circuitry processes both music language put more carbon in soils to meet paris climate pledges scientists call for eight steps to increase soil carbon for climate action and food security an xist activating antisense rna required for x chromosome inactivation x citing x chromosome discovery could aid research on many sex linked disorders etmopterus lailae sp. nov. a new lanternshark squaliformes etmopteridae from the northwestern hawaiian islands new shark species glows in the dark weighs about pounds and has a huge nose on the existence of accretion driven bursts in massive star formation birth of massive stars is accompanied by strong luminosity bursts perinatal nicotine exposure induces asthma in second generation offspring smoking causes asthma in second generation offspring study shows circulating tumor dna measurements as early outcome predictors in diffuse large b cell lymphoma liquid biopsy predicts lymphoma therapy success within days mass extinctions drove increased global faunal cosmopolitanism on the supercontinent pangaea mass extinctions led to low species diversity dinosaur rule serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in drosophila discovery of wound healing genes in flies could mitigate human skin ailments topical administration of allogeneic mesenchymal stem cells seeded in a collagen scaffold augments wound healing and increases angiogenesis in the diabetic rabbit ulcer pre clinical research shows promising treatment for diabetic wounds using stem cells the role of part time special education supporting students with reading and spelling difficulties from grade to grade in finland children with reading and spelling difficulties lag behind their peers despite special education strategies to identify the lynch syndrome among patients with colorectal cancer a cost effectiveness analysis screening new colon cancer patients for lynch syndrome would be cost effective study shows long neural genes harbor recurrent dna break clusters in neural stem progenitor cells breakable genes may promote disease brain cell diversity reconstitution of the gut microbiota of antibiotic treated patients by autologous fecal microbiota transplant fecal microbiota transplantation helps restore beneficial bacteria in cancer patients nonecholocating fruit bats produce biosonar clicks with their wings non echolocating fruit bats actually do echolocate with wing clicks snow shovel related injuries and medical emergencies treated in us eds to emergency department visits related to snow shoveling each year national us study finds nerve growth factor gene therapy using adeno associated viral vectors prevents cardiomyopathy in type diabetic mice can nerve growth factor gene therapy prevent diabetic heart disease ? whole organism transcriptomic analysis provides mechanistic insight into the acute toxicity of emamectin benzoate in daphnia magna anti sea lice drugs may pose hazard to non target crustaceans early childcare type predicts children s emotional and behavioural trajectories into middle childhood. data from the eden mother child cohort study nurseries may trump informal or childminder care for kids psychological development symbiotic streptomycetes provide antibiotic combination prophylaxis for wasp offspring beewolves protect their offspring with antibiotics digger wasp larvae use bacteria against infections long term progression free and overall survival in two melanoma patients treated with patient specific therapeutic vaccine eltrapuldencel t after resection of a solitary liver metastasis long term survival achieved in metastatic melanoma with personalized vaccine progressive proximal to distal reduction in expression of the tight junction complex in colonic epithelium of virally suppressed hiv individuals leaky gut source of non aids complications in hiv positive patients redox nanodomains are induced by and control calcium signaling at the er mitochondrial interface nanodomains of reactive oxygen species control mitochondrial energy output egr immediate early gene and the brain derived neurotrophic factor in bipolar disorder a new path into bipolar disorder comes to light comparison of mastoscopic and conventional axillary lymph node dissection in breast cancer long term results from a randomized multicenter trial minimally invasive lymph node dissection in breast cancer has advantages over conventional surgery childhood predictors of completed and severe suicide attempts findings from the finnish birth cohort study mental health problems in childhood may predict later suicide attempts in males treatment associated toxicities reported by patients with early stage invasive breast cancer half of breast cancer patients experience severe side effects updated clinical guidelines for diagnosing fetal alcohol spectrum disorders new improved guidelines for diagnosing fetal alcohol spectrum disorder dreaming of you client and therapist dreams about each other during psychodynamic psychotherapy sweet dreams ? client and therapist dreams of each other during psychodynamic psychotherapy alzheimer s disease peptide amyloid interacts with fibrinogen and induces its oligomerization alzheimer s therapy for brain disease could target blood exposure to mild blast forces induces neuropathological effects neurophysiological deficits and biochemical changes mild blast forces cause brain pathology and deficits despite lack of macroscopic damage cancer associated fibroblasts are activated in incipient neoplasia to orchestrate tumor promoting inflammation in an nf b dependent manner infiltrating cancer s recruitment center how beneficial cells are subverted to support cancer growth impulse control disorders in parkinson disease a cross sectional study of patients parkinson s disease treatments associated with compulsive behaviors a new dirivultid copepod siphonostomatoida from hydrothermal vent fields of the izu bonin arc in the north pacific ocean japanese student discovers new crustacean species in deep sea hydrothermal vent functional correction in mouse models of muscular dystrophy using exon skipping tricyclo dna oligomers scientists develop active substance for fatal muscle wasting in male children development and validation of a smartphone based visual acuity test peek acuity for clinical practice and community based fieldwork peek eye testing app shown to work as well as charts for visual acuity climatic and biotic thresholds of coral reef shutdown la ni a like conditions associated with year long shutdown of coral reef growth compact genome of the antarctic midge is likely an adaptation to an extreme environment antarctic midge s genome is smallest in insects to date bare bones genome is adaptation to deep freeze age related differences in the cloacal microbiota of a wild bird species the scoop on bird poop evolving diversity of microbial life in bird guts self organization of the in vitro attached human embryo new method allows first look at key stage of human development embryo implantation preexisting influenza specific cd t cells correlate with disease protection against influenza challenge in humans key peptides that could lead to universal vaccine for influenza identified ipsc derived human microglia like cells to study neurological diseases skin stem cells used to generate new brain cells compression of morbidity is observed across cohorts with exceptional longevity living longer associated with living healthier study of centenarians finds randomised controlled trial of stand alone tailored emails for smoking cessation customized frequent emails show promise in tobacco cessation a small recurrent deletion within q. is associated with a range of neurodevelopmental phenotypes developmental delay could stem from nicotinic receptor deletion how to win public support for a global carbon tax economist find a global tax on carbon may be feasible demographic compensation does not rescue populations at a trailing range edge demographic compensation may not save plants facing changing climate non estrogenic xanthohumol derivatives mitigate insulin resistance and cognitive impairment in high fat diet induced obese mice compounds derived from hops show promise for metabolic syndrome patients impact of short lived non co mitigation on carbon budgets for stabilizing global warming accounting for short lived forcers in carbon budgets co adjuvant effects of retinoic acid and il induce inflammatory immunity to dietary antigens human and mouse studies sharpen focus on cause of celiac disease the role of green roofs in climate change mitigation. a case study in seville spain green roofs to reduce the effects of climate change total knee arthroplasty in patients with blount disease or blount like deformity knee replacement is effective treatment for degeneration caused by blount disease irisin mediates effects on bone and fat via v integrin receptors exercise induced hormone irisin triggers bone remodeling in mice calcifying coral abundance near low ph springs implications for future ocean acidification submarine springs offer preview of ocean acidification effects on coral reefs diagnostic yield of sequencing familial hypercholesterolemia genes in patients with severe hypercholesterolemia single gene mutations account for only percent of cases of severely elevated cholesterol auditory training of speech recognition with interrupted and continuous noise maskers by children with hearing impairment noisy classroom simulation aids comprehension in hearing impaired children isocyanic acid in the atmosphere and its possible link to smoke related health effects smoke related chemical discovered in the atmosphere could have health implications warming effects of spring rainfall increase methane emissions from thawing permafrost early spring rain boosts methane from thawing permafrost by percent extended release of perioperative immunotherapy prevents tumor recurrence and eliminates metastases gradual release of immunotherapy at site of tumor surgery prevents tumors from returning zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage new mouse model reveals extensive postnatal brain damage caused by zika infection assessing the impact of medication adherence on long term cardiovascular outcomes full adherence to guideline recommend therapies associated with lower rate of mace independent contribution of a c systolic blood pressure and ldl cholesterol control to risk of cardiovascular disease hospitalizations in type diabetes an observational cohort study blood pressure cholesterol most important indicators of heart disease risk in diabetics satisfaction with primary care provider involvement is associated with greater weight loss results from the practice based power trial physician support key to successful weight loss study shows egf polymorphism predicts complete pathologic response to cetuximab based chemoradiation independent of kras status in locally advanced rectal cancer patients researchers link genetic marker to rectal cancer treatment assessing climate change vulnerability in urban america stakeholder driven approaches study assesses climate change vulnerability in urban america tropical fish diversity enhances coral reef functioning across multiple scales fish diversity linked to caribbean coral reef health rheb gtpase regulates secretase levels and amyloid generation scientists find regulator of amyloid plaque buildup in alzheimer s disease mannitol facilitates neurotrophic factor up regulation and behavioural recovery in neonatal hypoxic ischaemic rats with human umbilical cord blood grafts mannitol boosts effectiveness of potential cord blood treatment for cerebral palsy in lab animals study finds molecular clocks indicate turnover and diversification of modern coleoid cephalopods during the mesozoic marine revolution shedding new light on the evolution of the squid caregivers interactions with health care services mediator of stress or added strain ? experiences and perceptions of informal caregivers of people with dementia a qualitative study better support needed for thousands of informal dementia carers uncovering the neurobehavioural comorbidities of epilepsy over the lifespan study points to potential for improvement in the care quality of life of epilepsy patients the relationship between disordered eating and sexuality amongst adolescents and young adults bisexual and questioning women have higher risk of eating disorders transforming activity and therapeutic targeting of c terminal binding protein in apc mutated neoplasia study uncovers potential silver bullet for preventing and treating colon cancer the synergistic effect of concomitant schistosomiasis hookworm and trichuris infections on children s anemia burden schistosomes hookworm and trichuris infections synergize to increase the risk of anemia estimating regimen specific costs of chemotherapy for breast cancer observational cohort study significant cost differences found between breast cancer chemotherapy regimens association of maternal plasma folate and cardiometabolic risk factors in pregnancy with elevated blood pressure of offspring in childhood high folic acid level in pregnancy may decrease high blood pressure in children children of katrina lessons learned about postdisaster symptoms and recovery patterns hurricane katrina s effects on children resilience and gender structural studies ofacidianustailed spindle virus reveal a structural paradigm used in the assembly of spindle shaped viruses virus that lives in yellowstone hot springs described two step reactivation of dormant cones in retinitis pigmentosa researchers discover procedure to regenerate dormant cone cells potentially to improve vision in retinitis pigmentosa rational development and characterization of humanized anti egfr variant iii chimeric antigen receptor t cells for glioblastoma development of personalized cellular therapy for brain cancer spatiotemporal patterns and transcription kinetics of induced rna in single bacterial cells rna network seen in live bacterial cells for first time probabilistic spatial risk assessment of heat impacts and adaptations for london future heat waves pose risk for population of greater london isoform specific antibodies reveal distinct subcellular localizations of c orf in amyotrophic lateral sclerosis mixed up cell transportation key piece of als dementia puzzle prostaglandin e is produced by adult human epidermal melanocytes in response to uvb in a melanogenesis independent manner skins prone to sunburn may be capable of a normal tan a gradient of bmp specifies the tonotopic axis in the developing inner ear pitch detection secrets of the inner ear revealed by research impact of a stepwise introduction of smoke free legislation on the rate of preterm births analysis of routinely collected birth data smoking bans linked with successive reductions in preterm birth a basal contribution from p modes to the alfv nic wave flux in the sun s corona evidence for a new fundamental constant of the sun high energy density and reversibility of iron fluoride cathode enabled via an intercalation extrusion reaction tripling the energy storage of lithium ion batteries american brain tumor association adolescent and young adult primary brain and central nervous system tumors diagnosed in the united states in malignant brain tumors most common cause of cancer deaths in adolescents and young adults association between hospitalization with community acquired laboratory confirmed influenza pneumonia and prior receipt of influenza vaccination patients with flu associated pneumonia less likely to have received flu vaccine genetic fuzzy based artificial intelligence for unmanned combat aerial vehicle control in simulated air combat missions new artificial intelligence beats tactical experts in combat simulation effects of short term mild hypercapnia during head down tilt on intracranial pressure and ocular structures in healthy human subjects genetic differences may alter carbon dioxide sensitivity contribute to changes in astronauts eyes intranasal poly ic treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen permissive monocyte macrophage population experimental immune boosting drug worsens tuberculosis in mice phospholipase d activity couples plasma membrane endocytosis with retromer dependent recycling the balancing act an enzyme that links endocytosis to membrane recycling radiation and dual checkpoint blockade activate non redundant immune mechanisms in cancer radiation plus immunotherapy combo revs up immune system to better attack metastatic melanoma study suggests chironomid inferred holocene temperature reconstruction in basa de la mora lake central pyrenees holocene temperature in the iberian peninsula reconstructed studying insect subfossils who s missing ? predictors of attrition following participation in culturally targeted educational breast and cervical cancer outreach programs for latinas understanding why some latina women discontinue participation in cancer prevention outreach neonatal brain injuries in england population based incidence derived from routinely recorded clinical data held in the national neonatal research database incidence of brain injury in babies estimated for first time using routine nhs data when do incidental mood effects last ? lay beliefs versus actual effects moody memories ? mood has limited effect on memory study shows effect of an implantable gentamicin collagen sponge on sternal wound infections following cardiac surgery a randomized trial use of surgically implanted antibiotic sponge does not reduce rate of sternal wound infections rare deletions at p. predispose to a diverse spectrum of sporadic epilepsy syndromes rare gene variants linked to high risk of broad range of seizure disorders sequence specific antimicrobials using efficiently delivered rna guided nucleases battling superbugs two new technologies could enable novel strategies for combating drug resistant bacteria pilot study of myocardial ischemia induced metabolomic changes in emergency department patients undergoing stress testing blood test for specific metabolites could reveal blocked arteries unravelling the baffling mystery of the ultrahot wind phenomenon in white dwarfs ultra hot gas around remnants of sun like stars uterine rupture by intended mode of delivery in the uk a national case control study uterine rupture is rare in the uk but increases with the number of previous cesarean deliveries denosumab versus risedronate in glucocorticoid induced osteoporosis a multicentre randomised double blind active controlled double dummy non inferiority study drug effectiveness in reducing glucocorticoid induced bone loss lactobacillus reuteri induces gut intraepithelial cd cd alpha alpha t cells protein rich diet may help soothe inflamed gut atmospheric evidence for a global secular increase in carbon isotopic discrimination of land photosynthesis rising co leading to changes in land plant photosynthesis renal medullary and urinary oxygen tension during cardiopulmonary bypass in the rat mathematical simulation of open heart surgery lends clues to kidney failure comparison of the etiology of viral respiratory illnesses in inner city and suburban infants inner city infants have different patterns of viral respiratory illness than infants in the suburbs adolescent male hazardous drinking and participation in organised activities involvement in team sports is associated with less hazardous drinking in young offenders teens who participate in sports show lower levels of hazardous drinking a soft robotic exosuit improves walking in patients after stroke soft wearable robotic suit promotes normal walking in stroke patients opening new approaches to gait re training and rehabilitation the dynamics of phenotypic change and the shrinking sheep of st. kilda climate change and the mystery of the shrinking sheep p kip is a microtubule associated protein that promotes microtubule polymerization during neuron migration a novel function for p protein in the control of interneuron migration in the developing cerebral cortex patient acceptability and satisfaction with a low dose solubilized vaginal estradiol softgel capsule tx hr high rates of satisfaction for applicator free local estrogen softgel ovule relaxation response and resiliency training and its effect on healthcare resource utilization relaxation response based program may reduce participants future use of health services weight stigma among active duty u.s. military personnel with overweight and obesity nearly one half of service members with overweight obesity report weight stigma prospective study of coronary heart disease vs. hdl hdl and other lipoproteins in gofman s livermore cohort from dusty punch cards new insights into link between cholesterol and heart disease bidirectional influence of sodium channel activation on nmda receptor dependent cerebrocortical neuron structural plasticity natural product produced by marine algae shows promise in stroke recovery treatment climate similarity search geoweb tool for exploring climate variability new interactive map shows climate change everywhere in world detection of a novel frameshift mutation and regions with homozygosis within arhgef gene in familial amyotrophic lateral sclerosis new genetic mutation for amyotrophic lateral sclerosis identified impact of abrupt deglacial climate change on tropical atlantic subsurface temperatures past tropical climate change linked to ocean circulation nor ursodeoxycholic acid improves cholestasis in primary sclerosing cholangitis initial successes in treating a hitherto incurable liver disorder wide open accelerating public data release by automating detection of overdue datasets wide open accelerates release of scientific data by identifying overdue datasets hydrogen sulfide protects testicular germ cells against heat induced injury novel way of protecting male reproductive cells discovered hails new approach to addressing male infertility relationship between the cervical microbiome hiv status and precancerous lesions cervical microbiome may promote high grade precancerous lesions upregulation of mirna promotes tumour angiogenesis by targeting vhl and is associated with poor prognosis and triple negative breast cancer one specific microrna promotes tumor growth and cancer spread calorie restriction as an anti invasive therapy for malignant brain cancer in the vm mouse starve a cancer calorie restriction as an anti invasive therapy for malignant brain cancer groundwater depletion a significant unreported source of atmospheric carbon dioxide groundwater depletion could be significant source of atmospheric carbon dioxide inter pregnancy weight change and risks of severe birth asphyxia related outcomes in singleton infants born at term a nationwide swedish cohort study maternal weight gain between pregnancies is linked to complications and adverse outcomes from specific examples to general knowledge in language learning nothing beats a good night s sleep for helping people absorb new information new research reveals extended release naltrexone to prevent opioid relapse in criminal justice offenders naltrexone is alternative treatment for opioid addiction study finds the memory enhancing effects of hippocampal estrogen receptor activation involve metabotropic glutamate receptor signaling study helps deconstruct estrogen s role in memory sex specific genetic effects associated with pigmentation sensitivity to sunlight and melanoma in a population of spanish origin researchers discover genetic causes of higher melanoma risk in men increased capsaicin receptor trpv expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain common bowel problem linked to chili pepper pain receptor a randomized double blind comparison of real and placebo acupuncture in ivf treatment. placebo acupuncture is associated with higher pregnancy rate after ivf than real acupuncture restoring voluntary control of locomotion after paralyzing spinal cord injury walking and running again after spinal cord injury abnormal visual contrast acuity in parkinson s disease parkinson s disease patients have reduced visual contrast acuity prairie strips improve biodiversity and the delivery of multiple ecosystem services from corn soybean croplands strips of prairie plants slow loss of soil nutrients and water from ag fields double biodiversity local and long range functional connectivity is reduced in concert in autism spectrum disorders impaired coordination of brain activity in autism involves local as well as long range signaling a tomographic osteology of the taxonomically puzzling catfishkryptoglanis shajii siluriformes siluroidei incertae sedis description and a first phylogenetic interpretation a tiny toothy catfish with bulldog snout defies classification back pain mental health and substance use are associated in adolescents back pain linked to mental health problems and risky behaviors in teenagers loss and gain of natural killer cell receptor function in an african hunter gatherer population unique genes in khoe san people may lower risk of some pregnancy hazards individual differences in response to cognitive training using a multi modal attentionally demanding game based intervention for older adults world of warcraft boosts cognitive functioning in older adults ret inhibition decreases growth and metastatic potential of estrogen receptor positive breast cancer cells new approach in the treatment of breast cancer evolution of opsin expression in birds driven by sexual selection and habitat female color perception affects evolution of male plumage in birds a hierarchical d nanostructured microfluidic device for sensitive detection of pathogenic bacteria nano sized traps show promise in diagnosing pathogenic bacterial infections teen dating violence physical and sexual among us high school students survey of teen dating violence among us high school students alzheimer s disease fdg pet imaging pattern in an amyloid negative mild cognitive impairment subject naturally occurring protein fragment found in the brain inhibits key enzyme implicated in alzheimer s disease loss of cardio protective effects at the adamts locus due to gene smoking interactions scientists find a likely genetic driver of smoking related heart disease selective autophagy of bes mediated by dsk balances plant growth and survival plant scientists untangle the molecular mechanisms connecting plant stress and growth topological defects in epithelia govern cell death and extrusion defects in epithelial tissue organization a question of life or death biomass offsets little or none of permafrost carbon release from soils streams and wildfire an expert assessment biomass offsets little or none of permafrost carbon release neuroprotective role of trans resveratrol in a murine model of familial alzheimer s disease researchers corroborate neuroprotective effects of sirtuin activation on mice with alzheimer s disease working group the physical science basis by the ipcc and climate change reconsidered ii physical science language about climate change differs between proponents and skeptics heightened neurologic complications in children with pandemic h n influenza higher incidence of seizures seen in children with h n virus compared to seasonal flu hybridizing transgenic bt cotton with non bt cotton counters resistance in pink bollworm reversing pest resistance to biotech cotton the secret is in the mix suppression of sclerostin alleviates radiation induced bone loss by protecting bone forming cells and their progenitors through distinct mechanisms suppressing protein alleviates radiation induced bone loss in animal model communally breeding bats use physiological and behavioural adjustments to optimise daily energy expenditure mother bats expert at saving energy study shows wild female bats temperature regulation strategy is flexible fibrinogen activates bmp signaling in oligodendrocyte progenitor cells and inhibits remyelination after vascular damage blood clotting protein prevents repair in the brain china s aquaculture and the world s wild fisheries sustainable approach for the world s fish supply location location location eye tracking evidence that consumers preferentially view prominently positioned nutrition information consumers don t pay as much attention to nutrition fact labels as they think eye tracking study finds the societal and economic value of rotator cuff repair health economics study highlights long term benefits of rotator cuff surgery constraining the rate of oceanic deoxygenation leading up to a cretaceous oceanic anoxic event oae ma new technique offers clues to measure the deoxygenation of the ocean sports at work anticipated and persistent correlates of participation in high school athletics former athletes finish first in race for top jobs magic in the machine a computational magician s assistant magic tricks created using artificial intelligence for the first time impact of cardiorespiratory fitness on arrhythmia recurrence in obese individuals with atrial fibrillation the cardio fit study improving cardiorespiratory fitness reduces risk of arrhythmia recurrence simulating tactile signals from the whole hand with millisecond precision computer model simulates sense of touch from the entire hand predicting value of pain and analgesia nucleus accumbens response to noxious stimuli changes in the presence of chronic pain hurts so good chronic pain changes brain response to acute pain biochemical effects of ribose and nadh therapy in children with autism therapies to improve biochemical functions hold promise as treatments for people with autism induction of fear extinction with hippocampal infralimbic bdnf drug induces a memory of safety in rat brains the effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life complications at birth associated with lasting chemical changes in the brain the legacy of early abuse and neglect for social and academic competence from childhood to adulthood tracking the impact of early abuse and neglect atmospheric particulate matter pollution during the beijing olympics athletes spectators faced unprecedented air pollution at olympic games hypoxia induced epigenetic regulation and silencing of the brca promoter breast cancer tumor suppressor gene silenced by low oxygen molecular remission of infant b all after infusion of universal talen gene edited car t cells universal car t cell therapy helps beat a hard to treat pediatric cancer histologic and biochemical alterations predict pulmonary mechanical dysfunction in aging mice with chronic lung inflammation new virtual model reveals details of declining lung function in mice the effects of methylphenidate ritalin on the neurophysiology of the monkey caudal prefrontal cortex adhd drug ritalin has no effect on primate prefrontal cortex estimating population sizes of lions panthera leo and spotted hyaenas crocuta crocuta in uganda s savannah parks using lure count methods king of beasts losing ground in uganda s paradise suppressor of cytokine signaling socs protects against severe cytokine storm and enhances viral clearance during influenza infection ending the perfect storm protein key to beating flu pandemics mutations in vps perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans neurological disease in mice and humans linked to an unlikely gene etiology and neuropsychology of comorbidity between rd and adhd the case for multiple deficit models common genetic influences for adhd and reading disability neuronal circadian clock protein oscillations are similar in behaviourally rhythmic forager honeybees and in arrhythmic nurses active and doing great new clues to circadian clocks global mismatch between greenhouse gas emissions and the burden of climate change secondhand smoke nations producing less greenhouse gas most vulnerable to climate change aberrant brain functional connectivity in newborns with congenital heart disease before cardiac surgery newborns with congenital heart disease show signs of brain impairment even before cardiac surgery amyloid clearance defect in apoe astrocytes is reversed by epigenetic correction of endosomal ph ph imbalance in brain cells may contribute to alzheimer s disease crustal inheritance and a top down control on arc magmatism at mount st helens new imagery solves mystery of why mount st. helens is out of line with other volcanoes grammatonotus brianne a new callanthiid fish from philippine waters with short accounts of two other grammatonotus from the coral triangle new species described by the california academy of sciences in how patients lack of knowledge about oral bisphosphonates can interfere with medical and dental care some bisphosphonates users unfamiliar with drug s possible side effects on oral health red flags to screen for malignancy in patients with low back pain spinal cancer guidelines for diagnosis unsupported in patients with lower back pain precision benefit design using smarter deductibles to better engage consumers and mitigate cost related nonadherence new year new idea high value u.s. health plan concept aims for bipartisan appeal tissue factor and par promote microbiota induced intestinal vascular remodelling the body s bacteria affect intestinal blood vessel formation mitigation of postnatal ethanol induced neuroinflammation ameliorates trace fear memory deficits in juvenile rats ibuprofen may block damage from fetal alcohol exposure fetal intervention increases maternal t cell awareness of the foreign conceptus and can lead to immune mediated fetal demise immune system drives pregnancy complications after fetal surgery in mice a site of vulnerability on the influenza virus hemagglutinin head domain trimer interface human antibody reveals hidden vulnerability in influenza virus simultaneous two photon calcium imaging at different depths with spatiotemporal multiplexing new microscope records firing of thousands of individual neurons in d maternal smoking during pregnancy and bipolar disorder in offspring smoking during pregnancy may increase risk of bipolar disorder in offspring polymer gels with tunable ionic seebeck coefficient for ultra sensitive printed thermopiles new polymer mixture creates ultra sensitive heat sensor a cluster randomized controlled trial to evaluate an ambulatory primary care management program for patients with dyslipidemia the team study physician pharmacist collaborative care plans have little impact on clinical outcomes functional mri in awake dogs predicts suitability for assistance work brain scans of service dog trainees help sort weaker recruits from the pack four histone variants mark the boundaries of polycistronic transcription units in trypanosoma brucei knowledge of epigenetics helps scientists develop tool to study deadly parasite s histone code marrow inspired matrix cues rapidly affect early fate decisions of hematopoietic stem and progenitor cells changing the environment within bone marrow alters blood cell development visual cortical prosthesis with a geomagnetic compass restores spatial navigation in blind rats with geomagnetic compass hooked to the brain blind rats act like they can see breast tumor prognostic characteristics and biennial vs annual mammography age and menopausal status annual vs. biennial mammography and breast tumor prognostic characteristics can social media lead to labor market discrimination ? evidence from a field experiment can social media lead to labor market discrimination ? equation of motion coupled cluster methods for atoms and molecules in strong magnetic fields new method can model chemistry in extreme magnetic fields of white dwarfs targeted multifunctional lipid eco plasmid dna nanoparticles as efficient non viral gene therapy for leber s congenital amaurosis gene delivery system prevents vision loss from inherited eye disease microcins mediate competition among enterobacteriaceae in the inflamed gut proteins secreted by beneficial gut microbes shown to inhibit salmonella invasive e. coli repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction repetitive blast exposure causes cerebellar dysfunction in combat veterans circadian rest activity pattern changes in aging and preclinical alzheimer disease body clock disruptions occur years before memory loss in alzheimer s sex specific regulation of fear memory by targeted epigenetic editing of cdk epigenetics contribute to male and female differences in fear memory autistic like behaviour and cerebellar dysfunction in purkinje cell tsc mutant mice charting autism s neural circuitry deleting single gene results in autism like behavior and immunosuppressant drug prevents symptoms childhood maltreatment depressive symptoms and body dissatisfaction in patients with binge eating disorder the mediating role of self criticism severity of binge eating disorder linked to childhood sexual or emotional abuse researchers find aging and neurodegeneration are associated with increased mutations in single human neurons mutations in neurons accumulate as we age may explain normal cognitive decline and neurodegeneration global mismatch between species richness and vulnerability of reef fish assemblages marine protected areas inadequate for protecting fish and ocean ecology study finds predictors of long term mortality after bariatric surgery performed in veterans affairs medical centers superobesity chronic disease burden associated with risk of death following bariatric surgery concussion characteristics in high school football by helmet age recondition status manufacturer and model through academic years in the united states high school football helmets offer similar protections despite different prices an evaluation of a smartphone assisted behavioral weight control intervention for adolescents pilot study smartphones alone not the smart choice for teen weight control study finds nutritional quality of food as represented by the fsam nps nutrient profiling system underlying the nutri score label and cancer risk in europe results from the epic prospective cohort study eating foods with low nutritional quality ratings linked to cancer risk in large european cohort more than a lucrative liquid the risks for adult consumers of human breast milk bought from the online market adult craze for human breast milk purchased online poses serious health risks holocene enso related cyclic storms recorded by magnetic minerals in speleothems of central china caves in central china show history of natural flood patterns respiratory dermal and eye irritation symptoms associated with corexit ec a ec a following the deepwater horizon oil spill findings from the gulf study gulf spill oil dispersants associated with health symptoms in cleanup workers migraine and risk of cardiovascular disease in women prospective cohort study women with migraines have higher risk of cardiovascular disease mortality the prolonged survival of fibroblasts with forced lipid catabolism in visceral fat following encapsulation in alginate poly l lysine study in mice discovers injection of heat generating cells reduces belly fat physical structures of the type ia supernova remnant n b search for stellar survivor of a supernova explosion seeding selectivity and ultrasensitive detection of tau aggregate conformers of alzheimer disease test detects protein associated with alzheimer s and cte suppression of chemotherapy induced cytokine lipid mediator surge and ovarian cancer by a dual cox seh inhibitor surge protector a novel approach to suppressing therapy induced tumor growth and recurrence an observation of parental infanticide in dickcissels spiza americana video evidence and potential mechanisms evidence of parental infanticide in a grassland bird species chronic cholesterol depletion using statin impairs the function and dynamics of human serotonin areceptors new insights into link between anti cholesterol statin drugs and depression locomotor benefits of being a slender and slick sand swimmer slick and slender snake beats short and stubby lizard in sand swimming adolescents response to pictorial warnings on the reverse panel of cigarette packs a repeat cross sectional study back of pack health warnings make little impact on teen smokers population size and trends of southern giant petrels macronectes giganteus nesting at signy island south orkney islands new research shows decline in population and breeding success of antarctic seabird removal of dissolved silica from industrial waters using inorganic ion exchangers reducing power plants freshwater consumption with new silica filter millennial scale record of landslides in the andes consistent with earthquake trigger geologist reveals correlation between earthquakes landslides in peru the effectiveness of coral reefs for coastal hazard risk reduction and adaptation surviving storms coral reefs are critical for risk reduction and adaptation discrimination domestic violence abuse and other adverse life events in people with epilepsy population based study to assess the burden of these events and their contribution to psychopathology people with epilepsy face increased risks of discrimination and other negative life events active control over the wettability from superhydrophobic to superhydrophilic by electrochemically altering the oxidation state in a low voltage range wet or dry in an instant smart surface enables advanced manipulation of droplets damaging de novo mutations diminish motor skills in children on the autism spectrum autism genetics study calls attention to motor skills general cognitive impairment a revised cranial description of massospondylus carinatus owen dinosauria sauropodomorpha based on computed tomographic scans and a review of cranial characters for basal sauropodomorpha print a million year old dinosaur fossil in your own home a giant underwater encrusted stalactite from the blue hole lighthouse reef belize revisited a complex history of biologically induced carbonate accretion under changing meteoric and marine conditions in the footsteps of jacques cousteau researchers unveil the secret of the blue hole stalactite influenza vaccine given to pregnant women reduces hospitalization due to influenza in their infants fighting flu in newborns begins in pregnancy study suggests long term outcomes following therapy in differentiated thyroid carcinoma ntctcs registry analysis moderate hormone suppression may be enough in thyroid cancer year study shows is infant neural sensitivity to vocal emotion associated with mother infant relational experience ? mother s behavioral corrections tune infant s brain to angry tone fap mediates fusobacterium nucleatum colorectal adenocarcinoma enrichment by binding to tumor expressed gal galnac fusobacteria use a special sugar binding protein to bind to colon tumors fetal radiofrequency radiation exposure from mhz rated cellular telephones affects neurodevelopment and behavior in mice cell phone use in pregnancy may cause behavioral disorders in offspring mouse study suggests zwitterionic hydrogels implanted in mice resist the foreign body reaction engineered biomaterial could improve success of medical implants a new role for rrm in repair of replication born dna breakage by sister chromatid recombination the role of the protein rrm in the repair of breaks in dna during replication gene therapy targeting sarm blocks pathological axon degeneration in mice gene therapy blocks peripheral nerve damage in mice intrinsic pink noise multidecadal global climate dynamics mode parsing natural climate variability from human caused climate change antiadhesion therapy for urinary tract infections a balanced pk pd profile proved to be key for success non antibiotic approach for treating urinary tract infections an environment dependent transcriptional network specifies human microglia identity brain s immune cells linked to alzheimer s parkinson s schizophrenia metabolic syndrome in the elderly living in marginal peri urban communities in quito ecuador vitamins c and e linked to metabolic syndrome in low income ecuadorians the carnivorous venus flytrap uses prey derived amino acid carbon to fuel respiration scientists show how the venus flytrap uses its prey s nitrogen compounds to extract energy temperature dependence of trophic interactions are driven by asymmetry of species responses and foraging strategy life scientists present new insights on climate change and species interactions critically ill patients with influenza a h n in mexico critical illness from h n in mexico associated with high fatality rate systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats new robust treatment for stroke uses genetic material from bone marrow a snp in the htt promoter alters nf b binding and is a bidirectional genetic modifier of huntington disease gene variant determines early or late onset of huntington s disease usefulness of a simple algorithm to identify hypertensive patients who benefit from intensive blood pressure lowering algorithm identifies hypertensive patients who will benefit from intensive treatment multiplex determination of serological signatures in the sera of colorectal cancer patients using hydrogel biochips new d hydrogel biochips prove to be superior in detecting bowel cancer at early stages adolescent alcohol abuse and adverse adult outcomes evaluating confounds with drinking discordant twins adolescent alcohol abuse disrupts transitions into early adulthood capture of influenza by medullary dendritic cells via sign r is essential for humoral immunity in draining lymph nodes poorly understood cell plays role in immunity against the flu dental implant supported restorations improve quality of life in osteoporotic women dental implants result in better quality of life for osteoporotic women inspection of the human stomach using remote controlled capsule endoscopy a feasibility study in healthy volunteers with videos remote controlled capsule endoscope safely examines the stomach extended release naltrexone and harm reduction counseling for chronically homeless people with alcohol dependence anti craving drug counseling lower alcohol harm in homeless without sobriety demands low level expression of mir correlates with poor outcome and metastasis while altering the invasive properties of head and neck squamous cell carcinomas molecular fingerprint discovered that may improve outcomes for head and neck cancer patients efficient detection and purification of cell populations using synthetic microrna switches new biotechnology for high efficiency purification of live human cells a boosting skin vaccination with dissolving microneedle patch encapsulating m e vaccine broadens the protective efficacy of conventional influenza vaccines skin vaccination with microneedle patch influenza fusion protein improves efficacy of flu vaccines comparison of site of death health care utilization and hospital expenditures for patients dying with cancer in developed countries cost of end of life care in the us is comparable to europe canada the association of prenatal cocaine exposure externalizing behavior and adolescent substance use prenatal cocaine exposure increases risk of higher teen drug use inhibition of mutated activated braf in metastatic melanoma advanced melanoma new targeted therapy successful in more than percent of patients generation of matched patient derived xenograft in vitro in vivo models using d macroporous hydrogels for the study of liver cancer recreating liver tumors as organoids for faster more accurate drug screening finding missed cases of familial hypercholesterolemia in health systems using machine learning ai identifies risk of cholesterol raising genetic disease biogeography and change among regional coral communities across the western indian ocean coral reefs of mozambique channel leading candidate for saving marine diversity overexpression of the vascular brassinosteroid receptor brl confers drought resistance without penalizing plant growth researchers generate plants with enhanced drought resistance without penalizing growth single agent polysaccharopeptide delays metastases and improves survival in naturally occurring hemangiosarcoma mushroom derived compound lengthens survival in dogs with cancer study suggests population characteristics mechanisms of primary care and premature mortality in england a cross sectional study supply of gps detection of hypertension in england associated with premature mortality rates the global emergence of unregulated stem cell treatments for respiratory diseases. professional societies need to act unproven stem cell therapies for lung disease on the rise despite promise of new treatments cardiovascular disease cvd and chronic kidney disease ckd event rates in hiv positive persons at high predicted cvd and ckd risk a prospective analysis of the d a d observational study hiv patients at greater risk of both heart and kidney disease long term survival in glioblastoma with cytomegalovirus pp targeted vaccination immunotherapy for glioblastoma well tolerated survival gains observed near infrared imaging as a method of studying tsetse fly diptera glossinidae pupal development new insect imaging technique may help victims of sleeping sickness estimating the potential impact of the uk government s sugar reduction programme on child and adult health modelling study achieving sugar reduction targets could cut child obesity and healthcare costs constraints on trait combinations explain climatic drivers of biodiversity the importance of trait covariance in community assembly sowing new seeds of knowledge about the drivers of plant diversity changing lake dynamics indicate a drier arctic in western greenland climate change may make the arctic tundra a drier landscape evolutionary novelty is concentrated at the edge of coral species distributions caribbean coral reef protection efforts miss the mark research suggests associations between cerebrospinal fluid biomarkers and cognition in early untreated parkinson s disease biomarker for early cognitive decline in parkinson s disease patients identified use of benzodiazepines and related drugs is associated with a risk of stroke among persons with alzheimer s disease benzodiazepines related drugs increase stroke risk among persons with alzheimer s disease chemical and biological assessment of endocrine disrupting chemicals in a full scale dairy manure anaerobic digester with thermal pretreatment estrogen antibiotics persisted in dairy farm waste after advanced treatment research finds childhood body mass is positively associated with cesarean birth in yucatec maya subsistence farmers indigenous group add to evidence tying cesarean birth to obesity gender inequality in the risk of violence material deprivation is linked to higher risk for adolescent girls teenage girls face greater violence threat from poverty hypoxia induced human deoxyribonuclease i is a cellular restriction factor of hepatitis b virus discovery of a restriction factor for hepatitis b virus systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous hiv transmission in humanized blt mice prep treatment prevented hiv transmission in humanized mice fmrp regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry new insights link fragile x syndrome autism spectrum disorders corrosion protection of silver based telescope mirrors using evaporated anti oxidation overlayers and aluminum oxide films by atomic layer deposition new mirror coating technology promises dramatic improvements in telescopes late pleistocene mammoth trackway from fossil lake oregon ancient trail of columbian mammoths uncovered in south central oregon comparative transcriptomics reveals the conserved building blocks involved in parallel evolution of diverse phenotypic traits in ants how the ant queen gets her crown uncovering the evolution of queen worker differences brain oxygenation declines in elite kenyan runners during a maximal interval training session brain oxygenation and the critical importance of pace in long distance races implications for educational classification and psychological diagnoses using the wechsler adult intelligence scale fourth edition with canadian versus american norms flawed iq scoring system important difference in american canadian scoring systems compartmentalized replication of r t cell tropic hiv in the central nervous system early in the course of infection researchers identify timeline for hiv replication in the brain divergences of two coupled human and natural systems on the mongolian plateau coupled human natural systems explain change on the mongolian plateau maintenance dfmo increases survival in high risk neuroblastoma dfmo increases survival for children with high risk neuroblastoma study finds obstructive sleep apnea and the prevalence and incidence of cancer no apparent link between sleep apnea and cancer large study pgrp sc promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan altering the community of gut bacteria promotes health and increases lifespan methyl cyclodextrin restores impaired autophagy flux in niemann pick c deficient cells through activation of ampk rare disease clues found in cell s recycling system influences of nitrogen oxides and isoprene on ozone temperature relationships in the amazon rain forest human encroachment alters air quality over amazon rainforest evidence for ventilation through collective respiratory movements in giant honeybee apis dorsata nests asian giant honeybees may move in synchrony to ventilate nests biofilm associated bacterial amyloids dampen inflammation in the gut oral treatment with curli fibres reduces the severity of hapten induced colitis in mice study showcases potential new oral treatment for inflammatory bowel disease functionalized bioink with optical sensor nanoparticles for o imaging in d bioprinted constructs d bioprinting of living structures with built in chemical sensors interplay between vegf a and cmet signaling in human vestibular schwannomas and schwann cells researchers sheds new light on biological pathways of vestibular schwannomas automated identification of benthic epifauna with computer vision use of robots and artificial intelligence to understand the deep sea helium in the eroding atmosphere of an exoplanet hubble detects helium in the atmosphere of an exoplanet for the first time autism prevalence in china is comparable to western prevalence levels of autism in china similar to the west joint chinese uk study shows economic loss and alcohol consumption and problems during the to u.s. recession recessionary woes lead to adverse alcohol outcomes for men and middle aged americans effect of peer comparison letters for high volume primary care prescribers of quetiapine in older and disabled adults behavioral nudges lead to striking drop in prescriptions of potent antipsychotic salmo kottelati a new species of trout from alak r stream draining to the mediterranean in southern anatolia turkey teleostei salmonidae a new trout species described from the alak r stream in antalya turkey heavy episodic drinking on college campuses does changing the legal drinking age make a difference ? lowering the drinking age is unlikely to curb college binge drinking new study finds oral immunotherapy for treatment of egg allergy in children oral immunotherapy shows promise as treatment for egg allergy different megafauna vary in their seed dispersal effectiveness of the megafaunal fruit platymitra macrocarpa annonaceae for one tropical tree effective seed dispersal relies especially on elephants extraction of the landau migdal parameter from the gamow teller giant resonance in sn new insights into pion condensation and the formation of neutron stars predominant api m sensitization as risk factor for treatment failure in honey bee venom immunotherapy people allergic to insect venom need precision medical diagnosis treatment eye like ocelloids are built from different endosymbiotically acquired components human like eye in single celled plankton mitochondria plastids evolved together effect of older age on treatment decisions and outcomes among patients with traumatic spinal cord injury older patients with traumatic spinal cord injuries less likely to get surgery linking dynamic habitat selection with wading bird foraging distributions across resource gradients past water patterns drive present wading bird numbers stress state in the largest displacement area of the tohoku oki earthquake stress change during the tohoku oki earthquake illuminated a simple alkaline method for decellularizing human amniotic membrane for cell culture scientists design test new approach for corneal stem cell treatments disease specific alterations in the enteric virome in inflammatory bowel disease viruses may play unexpected role in inflammatory bowel diseases systematic revision of the taiwanese genus kurixalus members with a description of two new endemic species anura rhacophoridae emerald and gold two new precious eyed endemic tree frog species from taiwan a calcium collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia a randomized controlled trial new dietary supplement beats calcium vitamin d for bone strength organic synthesis on mars by electrochemical reduction of co naturally occurring batteries fueled organic carbon synthesis on mars depression anxiety and antidepressant treatment in women association with in vitro fertilization outcome depression anxiety may reduce chances of ivf pregnancy quantification of surgical margin length changes after excision of feline injection site sarcomas a pilot study study sheds light on determining surgical margins for feline tumors tau exacerbates excitotoxic brain damage in an animal model of stroke new mindset in the search for stroke therapies low energy surface flashover for initiation of electric propulsion devices new technology helps address big problems for small satellites phenotypic diversity and genotypic flexibility of burkholderia cenocepacia during long term chronic infection of cystic fibrosis lungs genetics reveal mysteries of hard to treat bacterial infection in cystic fibrosis regenerative medicine in facial plastic and reconstructive surgery a review the next frontier in facial plastic reconstructive surgery impact of exposure to electronic cigarette advertising on susceptibility and trial of electronic cigarettes and cigarettes in us young adults a randomized controlled trial new study assesses the impact of exposure to e cigarette ads on young adults direct visualization of individual aromatic compound structures in low molecular weight marine dissolved organic carbon scientists analyze first direct images of dissolved organic carbon from the ocean depletion of major pathogenic cells in asthma by targeting crth strategy for depleting immune cells implicated in asthma associated inflammation pharmacological properties of sak a novel t type voltage gated ca channel enhancer new drug sak may offer hope to alzheimer s disease patients massive ice avalanches on iapetus mobilized by friction reduction during flash heating giant ice avalanches on saturn s moon iapetus provide clue to extreme slippage elsewhere in the solar system different functional neural substrates for good and poor language outcome in autism brain imaging explains reason for good poor language outcomes in asd toddlers retinal image quality and night vision performance after alcohol consumption eye s optical quality deteriorates after alcohol consumption differentiation of mammary tumors and reduction in metastasis upon malat lncrna loss unusual drug generates exciting results in mouse models of metastatic breast cancer out of control means off the menu the case for ceasing consumption of luxury products from highly vulnerable species when international trade cannot be adequately controlled shark fin as a case study appetite for shark fin soup serious risk to threatened sharks structural control of mixed ionic and electronic transport in conducting polymers research improves conductive plastic for health energy other technologies complete protection of the balb c and c bl j mice against ebola and marburg virus lethal challenges by pan filovirus t cell epigraph vaccine pan filovirus t cell vaccine protects mice from ebola and marburg three dimensional in situ characterization of phase transformation induced austenite grain refinement in nickel titanium first of their kind d experiments shed new light on shape memory alloys dysfunction of nav. a skeletal muscle voltage gated sodium channel in sudden infant death syndrome a case control study potential genetic link in sudden infant death syndrome identified where no guideline has gone before retrospective analysis of resuscitation in the th century looking forward to the th century cardiac arrest remains a deadly problem but for different reasons from today rapid and independent memory formation in the parietal cortex brain s multi track road to long term memory blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist cancer drug could promote regeneration of heart tissue underplating in the himalaya tibet collision zone revealed by the hi climb experiment first complete image created of himalayan fault subduction zone cmx to prevent cytomegalovirus disease in hematopoietic cell transplantation novel drug prevents common viral disease in stem cell transplant patients neural substrates of normal and impaired preattentive sensory discrimination in large cohorts of nonpsychiatric subjects and schizophrenia patients as indexed by mmn and p a change detection responses in schizophrenia patients auditory cues sound bigger problems smoking and risk of amyotrophic lateral sclerosis a pooled analysis of prospective cohorts cigarette smoking associated with increased risk of developing amyotrophic lateral sclerosis physical association between a novel plasma membrane structure and centrosome orients cell division discovery of a unique subcellular structure determining the orientation of cell division probing planets in extragalactic galaxies using quasar microlensing astrophysicists discover planets in extragalactic galaxies using microlensing prepartum and postpartum maternal depressive symptoms are related to children s brain structure in preschool depression during pregnancy is associated with abnormal brain structure in children a brain to brain interface for real time sharing of sensorimotor information brain to brain interface allows transmission of tactile and motor information between rats sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir device attaches to damaged heart enabling delivery of multiple therapy doses light induced dynamic structural color by intracellular d photonic crystals in brown algae new type of opal formed by common seaweed practice of traditional chinese medicine for psycho behavioral intervention improves quality of life in cancer patients a systematic review and meta analysis nondrug interventions improve quality of life for chinese cancer patients glutamatergic synaptic integration of locomotion speed via septoentorhinal projections speed data for the brain s navigation system proliferative neural stem cells have high endogenous ros levels that regulate self renewal and neurogenesis in a pi k akt dependant manner neural stem cells maintain high levels of reactive oxygen species study finds patients with high mental health costs incur over percent more costs than other high cost patients heavy users of mental health care have substantially different patterns of health care use the effect of genotype and in utero environment on inter individual variation in neonate dna methylomes development in the womb new insight on epigenetic influence on baby accidental exposures to peanut in a large cohort of canadian children with peanut allergy peanut allergic children more at risk of exposure at home than at school outcomes associated with early preventive dental care among medicaid enrolled children in alabama effects of early preventive dental care in medicaid enrolled children greater costs sauna bathing is inversely associated with dementia and alzheimer s disease in middle aged finnish men frequent sauna bathing may protect men against dementia finnish study suggests coherent storage and manipulation of broadband photons via dynamically controlled autler townes splitting physicists create new simpler than ever quantum hard drive for light membrane localized estrogen receptor is required for normal organ development and function new functional roles on cell surfaces for estrogen discovered rapidly light activated surgical protein glue inspired by mussel adhesion and insect structural crosslinking new mussel inspired surgical protein glue close wounds open medical possibilities a unified framework for modelling sediment fate from source to sink and its interactions with reef systems over geological times untangling the role of climate on sediment and reef evolution over millennial timescales mitochondrial toxicity in human pregnancy an update on clinical and experimental approaches in the last years large amounts of mitochondrial toxic agents cross placenta barrier whole genome deep sequencing of hiv reveals the impact of early minor variants upon immune recognition during acute infection deeper view of hiv reveals impact of early mutations association of maternal cigarette smoking and smoking cessation with preterm birth study finds that quitting smoking during pregnancy lowers risk of preterm births randomized trial of omalizumab anti ige for asthma in inner city children omalizumab relieves seasonal asthma attacks in youth study finds naturally occurring eccentric cleavage products of provitamin a beta carotene function as antagonists of retinoic acid receptors potential dark side to diets high in beta carotene early specialty palliative care translating data in oncology into practice misunderstanding of palliative care leads to preventable suffering association of proton pump inhibitors with risk of dementia proton pump inhibitors may be associated with increased risk of dementia a neuronal pirna pathway inhibits axon regeneration in c.elegans discovery offers new genetic pathway for injured nerve regeneration single parent expression is a general mechanism driving extensive complementation of non syntenic genes in maize hybrids more genes are active in high performance maize high resolution dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling patients to benefit from new d visualizations of the heart personal sound amplification products vs a conventional hearing aid for speech understanding in noise certain otc less expensive hearing aids provide benefit similar to conventional hearing aid lacrosse injuries among high school boys and girls in the united states academic years through high school lacrosse players at risk for concussions other injuries study finds should infants and toddlers have frequent overnight parenting time with fathers ? the policy debate and new data. overnights at dad s home benefit divorced mothers fathers and their babies american adaptation social factors affecting new developments to address climate change study ranks six american cities on preparation for climate change an interactive decision support system for implementing sustainable relocation strategies for adaptation to climate change a multi objective optimization approach rising sea levels will lead to relocation relocation relocation math could address climate change population concerns vaginal seeding of infants born by caesarean section increased demand for vaginal seeding from new parents despite lack of evidence structural determinants of cadherin function in hearing and deafness structure of inner ear protein is key to both hearing and inherited deafness thermodynamic analysis of the binding of f fab and immunoglobulin g forms to its gp epitope reveals a strong influence of the immunoglobulin fc region on affinity designing future vaccinations against hiv could depend on research on the protein gp running wheel exercise reduces synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of parkinson s disease why exercise slows progression of parkinson s disease mutations in pnpla are linked to photoreceptor degeneration and various forms of childhood blindness genetic discovery about childhood blindness paves way for new treatments leveraging experienced consumers to attract new consumers an equilibrium analysis of displaying deal sales by daily deal websites daily deal websites can capitalize by displaying sales numbers conditional tolerance of temperate phages via transcription dependent crispr cas targeting discovery reveals how bacteria distinguish harmful vs. helpful viruses why cancer screening has never been shown to save lives and what we can do about it cancer screening has never been shown to save lives argue experts a genetic variant associated with vascular diseases is a distal regulator of endothelin gene expression five vascular diseases linked to one common genetic variant structure and dynamics of the active human parathyroid hormone receptor near atomic map of parathyroid hormone complex points toward new therapies for osteoporosis changes in forest productivity across alaska consistent with biome shift shifting biomes in alaska illustrated in new study calculation of the axion mass based on high temperature lattice quantum chromodynamics supercomputer comes up with a profile of dark matter cosmogan creating high fidelity weak lensing convergence maps using generative adversarial networks training a neural network to study dark matter maternal antioxidant supplementation prevents adiposity in the offspring of western diet fed rats antioxidants in pregnancy prevent obesity in animal offspring accelerated aging and clearance of host anti inflammatory enzymes by discrete pathogens fuels sepsis path to deadly sepsis varies by bacterial infection high complexity shrna libraries and pi kinase inhibition in cancer high fidelity synthetic lethality predictions cancer killing combination therapies unveiled with new drug screening tool tau positron emission tomography in former national football league players experimental pet scan detects abnormal tau protein in brains of living former nfl players minimal similarity in songs suggests limited exchange between humpback whales megaptera novaeangliae in the southern indian ocean southern indian ocean humpback whales found singing different tunes defining essential genes for human pluripotent stem cells by crispr cas screening in haploid cells scientists generate an atlas of the human genome using stem cells transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice intestinal bacteria alter gut and brain function study shows paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the f generation and alters the transcriptional profile of testis and sperm microrna obese dads pass on predisposition to obesity and metabolic disorders to their kids ancient mechanisms for the evolution of the bicoid homeodomain s function in fly development scientists go back to the future create flies with ancient genes to study evolution are coral reefs victims of their own past success ? victims of their own success acropora corals success and their defeat the graduate nurse education demonstration implications for medicare policy new medicare model produces expert nurses to address shortage of primary care antiphospholipid antibodies promote leukocyte endothelial cell adhesion and thrombosis in mice by antagonizing enos via gpi and apoer researchers uncover culprits in life threatening clotting disorder hand rearing release and survival of african penguin chicks abandoned before independence by moulting parents rescued abandoned penguin chicks survival similar to colony rates the splicing regulators esrp and esrp direct an epithelial splicing program essential for mammalian development disruptions of splicing proteins cause facial skin organ defects in young mice identification of a mutation in the extracellular domain of the epidermal growth factor receptor conferring cetuximab resistance in colorectal cancer new cause of resistance to colon cancer treatment identified adrenergic receptor deficiency in ghrelin expressing cells causes hypoglycemia in susceptible individuals blocking release of the hormone ghrelin may mediate low blood sugar effect stress mental health and burnout in national humanitarian aid workers in gulu northern uganda humanitarian aid workers in uganda show signs of stress depression and burnout garp dampens cancer immunity by sustaining function and accumulation of regulatory t cells in the colon the story of garp a potential target for cancer immunotherapy siglec is a novel dendritic cell receptor that mediates hiv trans infection through recognition of viral membrane gangliosides scientists discover how hiv virus gains access to carrier immune cells to spread infection detecting underlying cardiovascular disease in young competitive athletes pre screening for young athletes at risk of sudden cardiac death high throughput screening enhances kidney organoid differentiation from human pluripotent stem cells and enables automated multidimensional phenotyping robots grow mini organs from human stem cells a striking new species of leaf warbler from the lesser sundas as uncovered through morphology and genomics genomic analysis helps in discovery of unusual new bird species from indonesia association between exposure to anaesthesia and surgery and long term cognitive trajectories in older adults report from the mayo clinic study of aging anesthesia surgery linked to decline in memory and thinking emerging fungal pathogen ophidiomyces ophiodiicola in wild european snakes snake fungal disease identified in wild british snakes for first time closed loop control of targeted ultrasound drug delivery across the blood brain tumor barriers in a rat glioma model a delicate crossing controller developed to open the blood brain barrier with precision an assessment of the effects of alcohol consumption and prevention policies on traffic fatality rates in the enlarged eu. time for zero alcohol tolerance ? what is the best policy for reducing the impact of alcohol on the road accident rate ? wavelength modulated tunable diode laser absorption spectrometry for real time monitoring of microbial growth lasers help speed up detection of bacterial growth in packaged food preservation of uropygial gland lipids in a million year old bird ancient preen oil researchers discover million year old lipids in a fossil bird public health surveillance of dental pain via twitter using twitter for public health surveillance of dental pain long term effectiveness of varicella vaccine a year prospective cohort study varicella vaccine has long term effectiveness against chicken pox association of fat grafting with patient reported outcomes in postmastectomy breast reconstruction study examines use of fat grafting for postmastectomy breast reconstruction two stage nanoparticle delivery of piperlongumine and tumor necrosis factor related apoptosis inducing ligand trail anti cancer therapy two stage nanoparticle delivery of piperlongumine trail anti cancer therapy resting state functional connectivity alterations associated with six month outcomes in mild traumatic brain injury new mri method aids long term concussion prognosis association of skirt size and postmenopausal breast cancer risk in older women a cohort study within the uk collaborative trial of ovarian cancer screening skirt size increase linked to percent greater postmenopausal breast cancer risk blood transcriptomes reveal novel parasitic zoonoses circulating in madagascar s lemurs new way to detect human animal diseases tested in lemurs factors associated with the emotional distress of women family members of adults with serious mental illness caregivers of family members newly diagnosed with mental illness at risk for anxiety geographical variation in and evolutionary history of the sunda clouded leopard neofelis diardi mammalia carnivora felidae with the description of a new subspecies from borneo delving into the past of a big cat clouded leopard redefined convalescent plasma treatment reduced mortality in patients with severe pandemic influenza a h n virus infection possible new treatment for severe h n infection tai chi on psychological well being systematic review and meta analysis tai chi gets cautious thumbs up for psychological health olfaction and incident parkinson disease in us white and black older adults scratch and sniff test could predict parkinson s even earlier increasing homogeneity in global food supplies and the implications for food security increasing homogeneity of world food supplies warns of serious implications for farming and nutrition neural precursor cells induce cell death of high grade astrocytomas through stimulation of trpv neural precursor cells induce cell death in certain brain tumors the role of human transportation networks in mediating the genetic structure of seasonal influenza in the united states viral commuters how influenza viruses use transportation systems in the us will the nhs continue to function in an influenza pandemic ? a survey of healthcare workers in the west midlands uk uk would nhs staff go to work during a flu pandemic ? the eardrums move when the eyes move a multisensory effect on the mechanics of hearing when the eyes move the eardrums move too direct electrical stimulation of the amygdala enhances declarative memory in humans direct amygdala stimulation can enhance human memory for a day a reappraisal of the quantitative relationship between sugar intake and dental caries the need for new criteria for developing goals for sugar intake dental nutrition experts call for radical rethink on free sugars intake place based management can reduce human impacts on coral reefs in a changing climate place based management can protect coral reefs in a changing climate microrna is associated with non small cell lung cancer nsclc brain metastasis and mediates nsclc migration microrna role in brain metastasis biomarkers help predict lung cancer patients whose disease could spread to the brain vitamin d deficiency induces early signs of aging in human bone increasing the risk of fracture vitamin d deficiency linked to accelerated aging of bones genotype phenotype correlation promiscuity in the era of next generation sequencing next generation sequencing shakes up genotype phenotype correlation disease discoveries cultural engagement and incident depression in older adults evidence from the english longitudinal study of ageing regular trips out guard against depression in old age association of dual task gait with incident dementia in mild cognitive impairment dual gait testing as early predictor of dementia bundle sheath chloroplast volume can house sufficient rubisco to avoid limiting c photosynthesis during chilling scientists debunk potential link to crop cold tolerance papain degrades tight junction proteins of human keratinocytes in vitro and sensitizes c bl mice via the skin independent of its enzymatic activity or tlr activation enzyme in cosmetic products can act as allergen via the skin dumbo octopod hatchling provides insight into early cirrate life cycle first video of dumbo octopod hatchling shows that they look like mini adults multi ethnic study of atherosclerosisdisease. prevalence and progression of subclinical atherosclerosis in younger adults with low short term but high lifetime estimated risk for cardiovascular disease healthy younger adults could be at risk for heart disease coevolution of landesque capital intensive agriculture and sociopolitical hierarchy intensification of agriculture and social hierarchies evolve together study finds altered dna methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type diabetes type diabetes clues revealed from study of identical twins observational and ecological studies of dietary advanced glycation end products in national diets and alzheimer s disease incidence and prevalence new study postulates the role of dietary advanced glycation end products in the risk of alzheimer s disease talazoparib in patients with advanced breast cancer and a germline brca mutation parp inhibitor improves progression free survival in patients with advanced breast cancers association of attention deficit hyperactivity disorder and conduct disorder with early tobacco and alcohol use adhd conduct disorder linked to alcohol tobacco use in young teens efficacy of larotrectinib in trk fusion positive cancers in adults and children positive results for larotrectinib against trk fusion cancer structural basis for kdm a histone lysine demethylase inhibition by diverse compounds anticancer drug discovery structures of kdm histone demethylase inhibitors afatinib activity in platinum refractory metastatic urothelial carcinoma in patients with erbb alterations precision medicine brings new hope to those with advanced urothelial cancer targeting epha inhibits cancer growth by disrupting the tumor stromal microenvironment new ways to treat solid tumors using protein neutrophil to lymphocyte ratio as a bladder cancer biomarker assessing prognostic and predictive value in swog promising blood test fails to yield clues about best strategies for bladder cancer treatment combination of molecular alterations and smoking intensity predicts bladder cancer outcome smoking intensity and cancer markers predict seriousness of bladder cancer resistive evolution of toroidal field distributions and their relation to magnetic clouds tied in knots new insights into plasma behavior focus on twists and turns juvenile sea stars exposed to acidification decrease feeding and growth with no acclimation potential young sea stars suffer more from ocean acidification than adults genetic drift during systemic arbovirus infection of mosquito vectors leads to decreased relative fitness during host switching virus evolution differs by species of mosquito carrier physical realization of a quantum spin liquid based on a complex frustration mechanism novel state of matter observation of a quantum spin liquid long term administration of tolvaptan in autosomal dominant polycystic kidney disease long term effectiveness of therapy for common cause of kidney failure a scale to characterize the strength and impacts of atmospheric rivers new scale to characterize strength and impacts of atmospheric river storms half metre sea level fluctuations on centennial timescales from mid holocene corals of southeast asia sea level change in southeast asia years ago has implications for today robotic crabs reveal that female fiddler crabs are sensitive to changes in male display rate quick quick slow is no go in crab courtship dance early life second hand smoke exposure and serious infectious morbidity during the first eight years evidence from hong kong s children of birth cohort second hand smoke increases hospital admissions for all types of infectious diseases the impact of human population pressure on flying fox niches and the potential consequences for hendra virus spillover human intrusion on fruit bat habitats raises exposure risk to hendra virus in australia lit the first nonpeptide oxytocin receptor agonist that improves social interaction in a mouse model of autism compound improves social interaction in autism mouse model factors affecting seroprevalence of toxoplasma gondii in the endangered iberian lynx lynx pardinus toxoplasma gondii spreads in the habitat of the iberian lynx growth at cold temperature increases the number of motor neurons to optimize locomotor function temperature alters developing nervous system in frogs study shows where has all the road kill gone ? where oh where has the road kill gone ? symbiotic relationship between streptococcus mutans and candida albicans synergizes the virulence of plaque biofilms in vivo bacterium fungus team up to cause virulent tooth decay in toddlers impaired thermoregulation and beneficial effects of thermoneutrality in the xtg ad model of alzheimer s disease ad drop in body temperature linked to aging aggravates manifestations of alzheimer s disease c photosynthesis boosts growth by altering physiology allocation and size scientists discover c photosynthesis boosts growth by altering size structure of plant leaves roots effects of age and amyloid deposition on a dynamics in the human central nervous system marker for alzheimer s disease rises during day and falls with sleep a rubber transferase activator is necessary for natural rubber biosynthesis in dandelion rubber from dandelions key components in formation of rubber identified a genetically active nano calcium phosphate paste for bone substitution encoding the formation of bmp and vegf a balsam for the bones chemists develop a nanopaste for the repair of bone defects soluble hiv env trimers in adjuvant elicit potent and diverse functional b cell responses in primates non human primate study generates information relevant to hiv vaccine strategies glacial lake drainage in patagonia kyr and response of the adjacent pacific ocean catastrophic failure of south american ice age dam changed pacific ocean circulation and climate cardiac autonomic dysfunction and health related quality of life in patients with chronic obstructive pulmonary disease heart health impacts wellbeing of patients with chronic obstructive pulmonary disease slow release naltrexone implant versus oral naltrexone for improving treatment outcomes in people with hiv who are addicted to opioids a double blind placebo controlled randomised trial naltrexone implant helps hiv patients with opioid dependence prevent relapse norrin frizzled signaling in retinal vascular development and blood brain barrier plasticity research on blood vessel proteins holds promise for controlling blood brain barrier a ferrocene based conjugated oligoelectrolyte catalyzes bacterial electrode respiration bacteria fed synthetic iron containing molecules turn into electrical generators disruption of magnetic compass orientation in birds by radiofrequency electromagnetic fields computational study sheds doubt on latest theory of birds mysterious magnetic compass trophic cascades from wolves to grizzly bears in yellowstone of bears and berries return of wolves aids grizzly bears in yellowstone dynamic rearrangement in snake venom gland proteome insights intobothrops jararacaintraspecific venom variation snake venom composition could be related to hormones and diet genetic variants near timp and high density lipoprotein u associated loci influence susceptibility to age related macular degeneration additional genes associated with age related macular degeneration identified multiple dimensions of climate change and their implications for biodiversity climate change study reveals unappreciated impacts on biodiversity what ever happened to the cool kids ? long term sequelae of early adolescent pseudomature behavior what happens to cool kids ? new study sheds light cannabidiol attenuates seizures and social deficits in a mouse model of dravet syndrome cannabidiol benefits and mechanisms shown in mouse study of dravet syndrome gestational iron deficiency is associated with pica behaviors in adolescents pica in pregnant teens linked to low iron ensemble modeling informs hypoxia management in the northern gulf of mexico bold new approaches needed to shrink gulf of mexico dead zone and meet elusive goals hong kong s rich marine biodiversity the unseen wealth of south china s megalopolis hong kong hosts more than a quarter of all marine species recorded in china analysis of state specific prevalence regional differences and correlates of hookah use in u.s. adults hookah smoking rapidly emerging threat to the health of the nation s young adults functional genomic landscape of human breast cancer drivers vulnerabilities and resistance breast cancer study suggests new potential drug targets and combinations the influence of national temperature fluctuations on opinions about climate change in the u.s. since blowing hot and cold u.s. belief in climate change shifts with weather reducing fugitive methane emissions from the north american oil and gas sector a proposed science policy framework methane emissions reduction from oil and gas in north america examined three dimensional printing of bone extracellular matrix for craniofacial regeneration better bone replacement d printed bone with just the right mix of ingredients feeding problems and nutrient intake in children with autism spectrum disorders a meta analysis and comprehensive review of the literature children with autism at significant risk for feeding problems and nutritional deficits epha receptor is a key player in the metastatic onset of ewing sarcoma a potential new therapeutic target for ewing sarcoma trends in cause specific mortality among children aged years from to in india china brazil and mexico an analysis of nationally representative mortality studies most deaths in children aged to in india china brazil mexico are preventable bioelectric signalling via potassium channels a mechanism for craniofacial dysmorphogenesis in kcnj associated andersen tawil syndrome faulty bioelectric signal responsible for facial defects caused by rare genetic disorder clusterin impairs hepatic insulin sensitivity and adipocyte clusterin associates with cardiometabolic risk study links protein clusterin to cardiac and metabolic diseases floxuridine homomeric oligonucleotides hitchhike with albumin in situ for cancer chemotherapy transport of lipid conjugated floxuridine by natural serum albumin for delivery to cancer cells identification of donor microbe species that colonize and persist long term in the recipient after fecal transplant for recurrent clostridium difficile donor microbes persist two years after fecal transplant to treat c. difficile infection quality of life in children and adolescents with learning problems development and validation of the ld qol scale learning disabilities kids and families struggle beyond the academics national institute of mental health multisite eban hiv std prevention intervention for african american hiv serodiscordant couples a cluster randomized trial couple focused intervention appears effective in reducing hiv risk behaviors among african americans effects of developmental bisphenol a exposure on reproductive related behaviors in california mice peromyscus californicus a monogamous animal model bisphenol a affects sex specific reproductive behaviors in a monogamous animal species nutritional niche overlap potentiates the use of endophytes in biocontrol of a tree disease endophytic fungi in elm trees help protect them from dutch elm disease comparison of gadolinium concentrations within multiple rat organs after intravenous administration of linear versus macrocyclic gadolinium chelates intracranial pathology not necessary for gadolinium deposition in brain tissues a dementia associated risk variant near tmem b alters chromatin architecture and gene expression researchers drill down into gene behind frontotemporal lobar degeneration the scoliosis of richard iii last plantagenet king of england diagnosis and clinical significance new d representation of richard iii s spine shows spiral nature of his scoliosis odors are expressible in language as long as you speak the right language odors expressible in language as long as you speak right language consolation in the aftermath of robberies resembles post aggression consolation in chimpanzees like chimpanzees humans may console victims of aggression out of empathy a trojan horse bispecific antibody strategy for broad protection against ebolaviruses new trojan horse antibody strategy shows promise against all ebola viruses genetic and expression analysis of cattle identifies candidate genes in pathways responding to trypanosoma congolense infection scientists identify livestock genes to unlock protection against one of africa s oldest animal plagues synthetic progestins differentially promote or prevent dimethylbenz a anthracene u induced mammary tumors in sprague dawley rats breast cancer risk varies among different progestins used in hormone replacement therapy study finds are some people suffering as a result of increasing mass exposure of the public to ultrasound in air ? are people suffering as a result of ultrasound in the air ? association between maternal adherence to healthy lifestyle practices and risk of obesity in offspring results from two prospective cohort studies of mother child pairs in the united states mothers who follow five healthy habits may reduce risk of obesity in children diversity dynamics of miocene mammals in relation to the history of tectonism and climate climate change and mountain building led to mammal diversity patterns rapid and ultra sensitive quantitation of disease associated synuclein seeds in brain and cerebrospinal fluid by syn rt quic new brain disease test for parkinson s dementia with lewy bodies impact of maternal alcohol consumption on fetal growth and preterm birth binge drinking leads to a greater risk of preterm birth art influences hiv persistence in the female reproductive tract and cervicovaginal secretions antiretroviral therapy reduces hiv in the female reproductive tract delivery of pesticides to plant parasitic nematodes using tobacco mild green mosaic virus as a nanocarrier drug delivery method holds promise for controlling crop parasites controversy undermines support for state mandates on the human papillomavirus vaccine public support for hpv vaccine wanes when linked to controversy study finds public opinion about other vaccines remains unchanged environmental health impacts of feeding crops to farmed fish global shift in farmed fish feed may impact nutritional benefits ascribed to seafood predicting plant conservation priorities on a global scale machine learning helps predict worldwide plant conservation priorities house dust mite sensitization in toddlers predicts current wheeze at age years house dust mite test on wheezy toddlers predicts asthma in teen years birth delivery mode alters perinatal cell death in the mouse brain cesarean born mice show altered patterns of brain development study finds androgen therapy and rehospitalization in older men with testosterone deficiency testosterone therapy decreases hospital readmissions in older men with low testosterone d bite modeling and feeding mechanics of the largest living amphibian the chinese giant salamander andrias davidianus amphibia urodela chinese giant salamander strikes prey in front approaching from the side toward personalized nasal surgery using computational fluid dynamics virtual surgery shows promise in personalized treatment of nasal obstruction seasonal movement patterns and long range dispersal of asian citrus psyllid in florida citrus area wide management a must for asian citrus psyllid effects of cannabis on cognitive function in patients with multiple sclerosis marijuana use may hurt intellectual skills in multiple sclerosis patients a hot l retrotransposon evades somatic repression and initiates human colorectal cancer researchers demonstrate link between jumping gene colon cancer hiv and hepatitis c mortality in massachusetts spatial cluster and trend analysis of hiv and hcv using multiple cause of death geospatial study identifies hotspots in deaths from hiv aids hepatitis c in massachusetts large shifts in commercial landings of estuarine and bay bivalve mollusks in northeastern united states after with assessment of causes commercial shellfish landings decline likely linked to environmental factors the extinct flightless mihirungs aves dromornithidae cranial anatomy a new species and assessment of oligo miocene lineage diversity ancient lone star lizard lounged in lush tropical texas learning to see beneath the surface a qualitative analysis of family medicine residents reflections about communication teaching reflection to doctors to improve physician patient interactions no evidence of sexual risk compensation in the iprex trial of daily oral hiv preexposure prophylaxis no link between hiv prevention pill truvada increased sexual risk behavior patterns of change and continuity in ochre use during the late middle stone age of the horn of africa the porc epic cave record ochre use by middle stone age humans in porc epic cave persisted over thousands of years emergence of the east central south african genotype of chikungunya virus in brazil and the city of rio de janeiro may have occurred years before surveillance detection study traces the origins of chikungunya in brazil the influence of sex race ethnicity and educational attainment on human immunodeficiency virus death rates among adults decline in hiv deaths for most men women by race ethnicity education u.s. study finds poorer neurodevelopmental outcomes associated with cystoid macular edema identified in preterm infants in the intensive care nursery retinal swelling in premature infants tied to poorer neuro development eighth joint national committee panel recommendation for blood pressure targets revisited controversial blood pressure targets for older patients challenged by study an application of transfer to american football from observation of raw video to control in a simulated environment football analysis leads to advance in artificial intelligence inner hair cell loss disrupts hearing and cochlear function leading to sensory deprivation and enhanced central auditory gain hearing tests miss common form of hearing loss study shows a review of spinal cord stimulation systems for chronic pain spinal cord stimulation is a safe effective drug free treatment for chronic pain experts say longitudinal trajectories of television watching across childhood and adolescence predict bone mass at age years in the raine study children who watch lots of tv may have poor bone health later in life parallel changes in mate attracting calls and female preferences in autotriploid tree frogs frogs use calls to find mates with matching chromosomes tree frogs that look similar hear chromosome difference in calls living on the edge how philopatry maintains adaptive potential why female loggerhead sea turtles always return to their place of birth socioeconomic position and the risk of brain tumour a swedish national population based cohort study high levels of education linked to heightened brain tumor risk mice selectively bred for high voluntary wheel running have larger midbrains support for the mosaic model of brain evolution is athleticism linked to brain size ? exercise loving mice have larger midbrains model based comprehensive analysis of school closure policies for mitigating influenza epidemics and pandemics targeted school closure policies may help the fight against pandemic influenza reimplantation of cryopreserved ovarian tissue from patients with acute lymphoblastic leukemia is potentially unsafe technique to preserve fertility in young women may be unsafe for patients with leukemia host genetic variation affects resistance to infection with a highly pathogenic h n influenza a virus in mice genes may determine susceptibility to h n avian influenza a virus infection associations of cigarette smoking with rheumatoid arthritis in african americans. cigarette smoking increases rheumatoid arthritis risk in african americans groel from the endosymbiont buchnera aphidicola betrays the aphid by triggering plant defense betrayal of the aphids internal bacteria can turn on its host earliest isotopic evidence in the maya region for animal management and long distance trade at the site of ceibal guatemala first evidence of live traded dogs for maya ceremonies functional connectivity of visual cortex in the blind follows retinotopic organization principles study challenges view that sight based brain sensory network organization is impaired with blindness contemporary outcomes of patients with bladder cancer who were treated with radical cystectomy a canadian multicentre experience improved radical surgery techniques provide positive outcomes for bladder cancer patients a new genus and species of clingfish teleostei gobiesocidae from western australia new many toothed clingfish discovered with help of digital scans in utero exposure to anesthetics alters neuronal migration pattern in developing cerebral cortex and causes postnatal behavioral deficits in rats anesthesia sends neurons down the wrong path in unborn rat babies effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with type diabetes mellitus medication does not reduce risk of recurrent cardiac events among patients with diabetes an early woodland domesticated chenopod chenopodium berlandieri subsp. jonesianum cache from the tutela heights site ontario canada year old eastern north american quinoa discovered in ontario unsupervised phenotyping of severe asthma research program participants using expanded lung data computer analyzes massive clinical databases to properly categorize asthma patients use of machine learning to improve autism screening and diagnostic instruments effectiveness efficiency and multi instrument fusion machine learning puts new lens on autism screening and diagnostics a good life for all within planetary boundaries a good life for all within the planet s means a chromatin integration labelling method enables epigenomic profiling with lower input when less is more a promising approach for low cell number epigenomic profiling eltrombopag and improved hematopoiesis in refractory aplastic anemia platelet drug shows clinical benefits for severe unresponsive aplastic anemia body temperatures of modern and extinct vertebrates from c o bond abundances in bioapatite were dinosaurs warm or cold blooded ? first method for directly measuring body temperatures of extinct vertebrates influence of quality of relationship between patient with melanoma and partner on partner assisted skin examination education training for patients with melanoma and their partners on skin examinations partitioning direct and indirect effects reveals the response of water limited ecosystems to elevated co indirect effects of rising carbon dioxide levels on ecosystems more important than previously thought risk of mortality associated with antipsychotic monotherapy and polypharmacy among community dwelling persons with alzheimer s disease antipsychotic drug use increases risk of mortality among persons with alzheimer s disease anti tumour immunity controlled through mrna m a methylation and ythdf in dendritic cells cancer nullifying protein ythdf enhances anti tumor response lubricating ability of albumin and globulin on artificial joint implants a tribological perspective a slick way to test artificial knees and hips the role of tectonic stress in triggering large silicic caldera eruptions ample warning of supervolcano eruptions likely experts say the dna structure specific endonuclease mus mediates dna sensor sting dependent host rejection of prostate cancer cells nuclear dna gets cut activates immune system to attack cancer cells yellow fever in africa estimating the burden of disease and impact of mass vaccination from outbreak and serological data mass vaccination campaigns reduce the substantial burden of yellow fever in africa genetic profiling links changing sea ice to shifting beluga whale migration patterns impacts of climate warming declining sea ice on arctic whale migration seabird movement reveals the ecological footprint of fishing vessels fishing vessels have big ecological footprint powerful seabird magnets animals in healthcare facilities recommendations to minimize potential risks infection control experts outline guidance for animal visitations in hospitals autosomal recessive phosphoglucomutase pgm mutations link glycosylation defects to atopy immune deficiency autoimmunity and neurocognitive impairment new genetic syndrome identified that includes allergy immune deficiency neurocognitive impairment the super study protocol for a randomised controlled trial comparing follicle stimulating hormone and clomiphene citrate for ovarian stimulation in intrauterine insemination back to the future most efficient option for treating unexplained infertility a hidden markov model for reconstructing animal paths from solar geolocation loggers using templates for light intensity new model to track animal paths from solar geolocators facile noninvasive retinal gene delivery enabled by penetratin gene therapy in a droplet could treat eye diseases prevent blindness metabolic profiling of presymptomatic huntington s disease sheep reveals novel biomarkers new discovery is a step towards developing huntington s disease treatments before symptoms appear skin diseases are more common than we think screening results of an unreferred population at the munich oktoberfest skin diseases are more common than we think persistent antibody clonotypes dominate the serum response to influenza over multiple years and repeated vaccinations antibodies from earlier exposures affect response to new flu strains comparison of the performance of prognostic signatures for estrogen receptor positive breast cancer first comparison of common breast cancer tests finds varied accuracy of predictions vitamin d supplementation during pregnancy state of the evidence from a systematic review of randomised trials insufficient evidence to guide recommendations on vitamin d in pregnancy isotopes in teeth and a cryptic population of coastal freshwater seals chemical records in teeth confirm elusive alaska lake seals are one of a kind sociality density dependence and microclimates determine the persistence of populations suffering from a novel fungal disease white nose syndrome social bats pay a price with new fungal disease study determines which bats are headed for extinction new insights into fetal mammary gland morphogenesis differential effects of natural and environmental estrogens new organ culture system reveals effects of bpa exposure on fetal mammary glands encoding and reactivation patterns predictive of successful memory performance are topographically organized along the longitudinal axis of the hippocampus where memory is encoded and retrieved new findings in a long standing debate host genetic diversity enables ebola hemorrhagic fever pathogenesis and resistance improved mouse model will accelerate research on potential ebola vaccines treatments functional brain response to food images in successful adolescent weight losers compared with normal weight and overweight controls teen brain scans reveal a key to weight loss patterns of brain activation when mothers view their own child and dog an fmri study neurobiological basis of human pet relationship mothers brains respond differently to images of their child and their dog blood alcohol concentrations in suicide and motor vehicle crash decedents ages to examining alcohol use prior to suicides motor vehicle crash deaths serum perfluoroalkyl substances and cardiometabolic consequences in adolescents exposed to the world trade center disaster and a matched comparison group children exposed to chemicals in dust show early signs of risk of heart disease digital screen time limits and young children s psychological well being evidence from a population based study children s screen time guidelines too restrictive according to new research manipulation of receptor oligomerization as a strategy to inhibit signaling by tnf superfamily members discovery may lead to better treatments for autoimmune diseases bone loss primary spinal opc culture system from adult zebrafish to study oligodendrocyte differentiation in vitro introduction of a novel system for in vitro analyses of zebrafish oligodendrocyte progenitor cells world trade center related physical and mental health burden among new york city fire department emergency medical service workers leaves legacy of chronic ill health among emergency medical services workers new product trial use of edibles and unexpected highs among marijuana and hashish users in colorado trying new marijuana products and edibles is associated with unexpected highs defects in the alternative splicing dependent regulation of rest cause deafness novel drug therapy partially restores hearing in mice serotype specific immunity explains the incidence of diseases caused by human enteroviruses viral outbreaks could be predicted two years in advance by mathematical model scales an optical clearing palette for biological imaging real x ray vision see through brains ready for study direct observation of magnetization reversal by electric field at room temperature in co substituted bismuth ferrite thin film magnetization reversal achieved at room temperature using only an electric field clinical trials of integrative medicine testing whether magic works ? experts denounce clinical trials of unscientific alternative medicines non suicidal self injury as a predictor of active and passive suicidal ideation among iraq afghanistan war veterans self harm suicide ideation tightly linked in iraq afghanistan veterans recent infections are associated with decreased risk of rheumatoid arthritis a population based case control study recent gut and urinary tract infections may curb risk of rheumatoid arthritis the saccharomyces cerevisiae hrq and pif dna helicases synergistically modulate telomerase activity in vitro enzymes partner up to accelerate cancer aging diseases a comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells new tool for understanding als patients brain cells distinct emt programs control normal mammary stem cells and tumour initiating cells variations in cell programs control cancer and normal stem cells birch pollen allergen immunotherapy reprograms nasal epithelial transcriptome and recovers microbial diversity birch pollen allergen immunotherapy normalizes nasal gene expression and microbial community hpsc modeling reveals that fate selection of cortical deep projection neurons occurs in the subplate scientists solve the case of the missing subplate with wide implications for brain science the association of posttraumatic stress disorder and metabolic syndrome a study of increased health risk in veterans metabolic syndrome a risk for veterans with ptsd plasmodium parasitemia associated with increased survival in ebola virus infected patients connection between ebola survival and co infection with malaria parasites explored in new study beneficial effects of nitric oxide breathing in adult patients with sickle cell crisis nitric oxide impacts source of sickle cell pain crisis study suggests patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts in vitro grafts increase blood flow in infarcted rat hearts longitudinal changes of tau pet imaging in relation to hypometabolism in prodromal and alzheimer s disease dementia spread of tau protein measured in brains of alzheimer s patients the kmo allele encoding arg is associated with psychotic features in bipolar disorder type and with increased csf kyna level and reduced kmo expression new gene variant may explain psychotic features in bipolar disorder an in depth look at dna crystals through the prism of molecular dynamics simulations scientists achieve the first stable simulations of dna crystals blood lead levels and dental caries in u.s. children who do not drink tap water blood lead levels lower but tooth decay higher in children who do not drink tap water too big to be noticed cryptic invasion of asian camel crickets in north american houses asian camel crickets now common in u.s. homes quality improvement initiative to improve inpatient outcomes for neonatal abstinence syndrome non pharmacologic approaches improve outcomes for infants with neonatal abstinence syndrome evaluating the evidence on sitting smoking and health is sitting really the new smoking ? sitting is not the new smoking contrary to popular myth obesity induced hepatic steatosis is mediated by endoplasmic reticulum stress in the subfornical organ of the brain cellular stress in the brain may contribute to non alcoholic fatty liver disease radar evidence of subglacial liquid water on mars mars express detects liquid water hidden under planet s south pole procurement of equines for the horsemeat trade in great britain fears that pet ponies and donkeys traded for horsemeat in britain unfounded study finds relativistic electrons produced by foreshock disturbances observed upstream of earth s bow shock nasa finds unusual origins of high energy electrons association between disease modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis certain drugs lower risk of diabetes for patients with rheumatoid arthritis or psoriasis first record of neoempheria osten sacken diptera mycetophilidae biology in the neotropical region with associations between its larvae and fungi mysteries in the mushrooms first records of fungi feeding gnat larvae from south america a newly identified group of adolescents at invisible risk for psychopathology and suicidal behavior findings from the seyle study high media use reduced sleep low activity adolescents at invisible risk of mental ill health perception of risk of natural hazards a hazard mitigation plan framework disaster planning risk assessment vital to development of mitigation plans biochemical and physical signal gradients in hydrogels to control stem cell behavior signal gradients in d guide stem cell behavior description of nicrophorus efferens new species from bougainville island coleoptera silphidae nicrophorinae a bit of good luck a new species of burying beetle from the solomon islands archipelago digital x ray radiogrammetry of hand or wrist radiographs can predict hip fracture risk a study in women and men method for assessing hand bone density may identify those at high risk of hip fractures self harm suicidal behaviours and cyberbullying in children and young people systematic review young victims of cyberbullying twice as likely to attempt suicide and self harm study finds hypermetabolism in f fdg pet predicts favorable outcome following decompressive surgery in patients with degenerative cervical myelopathy pet predicts outcomes for patients with cervical spinal cord compression predation on dovekies by goosefish over deep water in the northwest atlantic ocean goosefish capture small puffins over deep water of northwest atlantic durable antibody responses following one dose of the bivalent human papillomavirus l virus like particle vaccine in the costa rica vaccine trial one dose of hpv vaccine may be enough to prevent cervical cancer disease associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder twin study reveals epigenetic alterations of psychiatric disorders nontuberculous mycobacteria associated lung disease united states in hospitalized persons nontuberculous mycobacteria lung disease on the rise in the united states study finds low cardiac index is associated with incident dementia and alzheimer s disease the framingham heart study poor heart function could be major risk for alzheimer s disease increasing medication possession at discharge for patients with asthma the meds in hand project innovative collaboration leads to improved discharge outcomes for children with asthma placing antismoking graphic warning posters at retail point of sale locations increases some adolescents susceptibility to future smoking graphic anti smoking posters may encourage some teens to begin smoking cigarettes comparison of neurocognitive function after anthracycline based chemotherapy vs nonanthracycline based chemotherapy no risk association observed for anthracycline chemotherapy cognitive decline effect of glucosamine on pain related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis a randomized controlled trial glucosamine appears to provide little benefit for chronic low back pain long term safety and efficacy of factor ix gene therapy in hemophilia b gene therapy provides safe long term relief for patients with severe hemophilia b adaptive cerebellar spiking model embedded in the control loop context switching and robustness against noise artificial cerebellum than enables robotic human like object handling developed the nucleoporin nup regulates embryonic stem cell pluripotency through gene silencing protein plays unexpected role in embryonic stem cells can marine cloud brightening reduce coral bleaching ? cloud brightening to cool seas can protect coral reefs targeted cooling could offer a year breathing space for coral protection a randomized trial evaluating bioimpedance spectroscopy versus tape measurement for the prevention of lymphedema following treatment for breast cancer interim analysis technology better than tape measure for identifying lymphedema risk an effective approach to prevent immune rejection of human esc derived allografts solution found to problem limiting development of human stem cell therapies the integration of radiation therapy and immunotherapy in melanoma management combining radiation with immunotherapy showing promise against melanoma the hypervariable region of streptococcus pyogenes m protein escapes antibody attack by antigenic variation and weak immunogenicity micro organisms are invisible to the immune system exercise therapy for functional capacity in chronic diseases an overview of meta analyses of randomised controlled trials strong evidence of the benefits of exercise therapy in chronic diseases resveratrol demonstrates antimicrobial effects against propionibacterium acnes in vitro antioxidant found in grapes uncorks new targets for acne treatment the more things change species losses detected in phoenix despite stability in bird socioeconomic relationships desert plants provided by homeowners offer habitat for desert bird species effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat a systematic review and meta analysis of randomized controlled trials replacing saturated fat with polyunsaturated fat may cut heart disease risk enjoying the possibility of defeat outcome uncertainty suspense and intrinsic motivation enjoying the possibility of defeat suspense uncertainty predict how much players enjoy a game anti aging potentials of methylene blue for human skin longevity common antioxidant could slow symptoms of aging in human skin cryogenian glaciation and the onset of carbon isotope decoupling global glaciation snowballed into giant change in carbon cycle direct interactive public education by breast radiologists about screening mammography impact on anxiety and empowerment study combats anxiety as barrier to breast cancer screening serum calcium and risk of sudden cardiac arrest in the general population low serum calcium may increase risk of sudden cardiac arrest using decision pathway surveys to inform climate engineering policy choices new tool for gauging public opinion reveals skepticism of climate engineering the effect of return policy leniency on consumer purchase and return decisions a meta analytic review researchers examine effect of return policies on consumer behavior periodontal infection and preterm birth successful periodontal therapy reduces the risk of preterm birth successful periodontal therapy may reduce the risk of preterm birth according to dental study targeted antiviral prophylaxis with oseltamivir in a summer camp setting preventive program associated with reduced spread of h n at summer camp unravelling the global invasion routes of a worldwide invader the red swamp crayfish procambarus clarkii global invasion routes of the red swamp crayfish described based on genetics constraining climate sensitivity and continental versus seafloor weathering using an inverse geological carbon cycle model weathering of rocks a poor regulator of global temperatures physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall long term physical activity has an anti aging effect at the cellular level halo effect for bariatric surgery collateral weight loss in patients family members halo effect family members of gastric bypass patients also lose weight study finds lack of soluble fiber drives diet induced adiposity in mice diet lacking soluble fiber promotes weight gain mouse study suggests estimating mortality rates of european ash fraxinus excelsior under the ash dieback hymenoscyphus fraxineus epidemic analysis estimates mortality from fungal infections of ash trees leukaemogenesis induced by an activating catenin mutation in osteoblasts common blood cancer may be initiated by single mutation in bone cells an integrated approach to historical population assessment of the great whales case of the new zealand southern right whale slow path to recovery for southern right whales suicide attempts among individuals with specific learning disorders an underrecognized issue one in women with learning disabilities has attempted suicide psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life threatening cancer a randomized double blind trial hallucinogenic drug psilocybin eases existential anxiety in people with life threatening cancer the risk of alzheimer s disease associated with benzodiazepines and related drugs a nested case control study benzodiazepines are associated with increased risk of alzheimer s disease systematic review of greenhouse gas emissions for different fresh food categories new study provides food carbon footprint pecking order ecosystem function and services of aquatic predators in the anthropocene impacts of marine and freshwater predators on ecosystems and society international students post graduation migration plans and the search for home international students concept of home shapes post graduation plans non specialist psychosocial interventions for children and adolescents with intellectual disability or lower functioning autism spectrum disorders a systematic review non specialist psychosocial interventions for children with autism spectrum disorders altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type diabetes active young adults with type diabetes have muscle complications omega augmentation of sertraline in treatment of depression in patients with coronary heart disease a randomized controlled trial use of omega with treatment for depression in heart disease patients may not provide benefit thyroidectomy in the professional singer neural monitored surgical outcomes outcomes after thyroid surgery for pro singers described in first study of its kind kidney function and cerebral blood flow the rotterdam study kidney impairment decreases blood flow to the brain boosting risk of brain disorders contemporary h n influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg adapted vaccine strains h n mutation in last year s flu vaccine responsible for lowered efficacy atopic disease and cardiovascular risk factors in us children children with common allergies have twice heart disease risk origins of female genital diversity predation risk and lock and key explain rapid divergence during an adaptive radiation female fish genitalia evolve in response to predators interbreeding ipcc reasons for concern regarding climate change risks the fire through the smoke working for transparency in climate projections probable person to person transmission of novel avian influenza a h n virus in eastern china epidemiological investigation first probable person to person transmission of new bird flu virus in china but h n is not able to spread efficiently between humans future response of global coastal wetlands to sea level rise global coastal wetlands need to move inland in fight against climate change omega polyunsaturated fatty acids promote amyloid clearance from the brain through mediating the function of the glymphatic system additional benefit of omega fatty acids for the clearance of metabolites from the brain enhancing mda il therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by ad. gene delivery virus based gene therapy for metastatic kidney cancer developed integrated analysis of population genomics transcriptomics and virulence provides novel insights into streptococcus pyogenes pathogenesis researchers find trigger that turns strep infections into flesh eating disease ptk regulates growth and survival of endocrine therapy resistant er breast cancer cells novel therapeutic target discovered for estrogen receptor positive er breast cancer commensal bacteria derived signals regulate basophil hematopoiesis and allergic inflammation inner weapons against allergies gut bacteria control allergic diseases study suggests concurrent and longitudinal contribution of exposure to bullying in childhood to mental healththe role of vulnerability and resilience anxiety and depression caused by childhood bullying decline over time efficient generation of human ipscs by a synthetic self replicative rna efficient model for generating human induced pluripotent stem cells does the contraceptive pill alter mate choice in humans ? unnatural selection birth control pills may alter choice of partners racial profiling and use of force in police stops how local events trigger periods of increased discrimination violence against police officers can trigger increased discrimination in police stops a comprehensive roadmap of murine spermatogenesis defined by single cell rna seq new insights on sperm production lay groundwork for solving male infertility the perception of a face is no more than the sum of its parts in recognizing faces the whole is not greater than the sum of its parts depression and anxiety symptoms onset developmental course and risk factors during early childhood depression and anxiety affect up to percent of preschoolers canadian study finds detection of undiagnosed hiv among state prison entrants prevalence of undiagnosed hiv infection low among state prison entrants parental desensitization to gun violence in pg movies parents say intense gun violence in pg movies appropriate for teens and older food label use and its relation to dietary intake among u.s. adults nutritional labeling and point of purchase signs influence healthy food choices taurine modified ru ii complex targets cancerous brain cells for photodynamic therapy a unique amino acid for brain cancer therapy soluble hiv envelope immunogens derived from an elite neutralizer elicit cross reactive v v antibodies and low potency neutralizing antibodies researchers identify two hiv envelope immunogens capable of eliciting antibodies associated with vaccine protection a polymorphic p response element in the kit ligand gene influences cancer risk and has undergone natural selection tanning gene linked to increased risk of testicular cancer fus regulates activity of microrna mediated gene silencing scientists discover a key function of als linked protein the base excision repair pathway is required for efficient lentivirus integration hiv integration requires use of a host dna repair pathway shock and kill effects of class i selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for hiv quiescence shock and kill research gives new hope for hiv eradication transcription upregulation via force induced direct stretching of chromatin mechanical force triggers gene expression by stretching chromatin genome wide association analysis identifies susceptibility loci for migraine without aura four new gene loci predisposing people to the most common subtype of migraine adverse weather conditions for european wheat production will become more frequent with climate change more frequent extreme adverse weather conditions threaten europe s wheat production genetic association study of qt interval highlights role for calcium signaling pathways in myocardial repolarization important new information on genetic risk of sudden cardiac death longitudinal examination of aggression and study skills from middle to high school implications for dropout prevention two behaviors linked to high school dropout rates interactions between cannabidiol and commonly used antiepileptic drugs compound derived from marijuana interacts with antiepileptic drugs effect of tree nuts on glycemic control in diabetes a systematic review and meta analysis of randomized controlled dietary trials eating tree nuts results in modest decreases in blood fats and sugars survey finds transdifferentiation of glioblastoma cells into vascular endothelial cells conversion of brain tumor cells into blood vessels thwarts treatment efforts advances in using internet searches to track dengue google searches can be used to track dengue in underdeveloped countries medical and psychosocial factors and unfavourable low density lipoprotein cholesterol control in coronary patients statin side effects are strongest predictor of failure to meet cholesterol targets inflammation free gas permeable lightweight stretchable on skin electronics with nanomeshes breathable wearable electronics on skin for long term health monitoring from disaster response to community recovery nongovernmental entities government and public health study calls on feds to invest in local volunteer disaster response recovery groups range position and climate sensitivity the structure of among population demographic responses to climatic variation wood frogs research clarifies risks posed to animals by warming climate culturally transmitted song exchange between humpback whales megaptera novaeangliae in the southeast atlantic and southwest indian ocean basins giant singers from neighboring oceans share song parts over time tau impairs neural circuits dominating amyloid effects in alzheimer models in vivo tau protein suppresses neural activity in mouse models of alzheimer s disease pvc gel soft actuator based wearable assist wear for hip joint support during walking artificial muscles power up with new gel based robotics experimental assays to assess the efficacy of vinegar and other topical first aid approaches on cubozoan alatina alata tentacle firing and venom toxicity new experiments determine effective treatments for box jelly stings dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury omega fatty acids lessen severity of osteoarthritis in mice live and inactivated influenza vaccines induce similar humoral responses but only live vaccines induce diverse t cell responses in young children any prime boost mix of injected or spray flu vaccine shields toddlers broadest immune response from nasal spray vaccine study finds synchronizing a single electron shuttle to an external drive strongly interacting electrons in wacky oxide synchronize to compute like the brain scientific and regulatory reasons for delay and denial of fda approval of initial applications for new drugs study examines reasons for delay denial of new drugs by fda micrometer sized molecular robot changes its shape in response to signal molecules shape shifting molecular robots respond to dna signals age at last birth in relation to risk of endometrial cancer pooled analysis in the epidemiology of endometrial cancer consortium women who give birth after age lower their risk of endometrial cancer water input into the mariana subduction zone estimated from ocean bottom seismic data seismic study reveals huge amount of water dragged into earth s interior mammographic breast density assessment using deep learning clinical implementation automated system identifies dense tissue a risk factor for breast cancer in mammograms development and validation of a risk score for chronic kidney disease in hiv infection using prospective cohort data from the d a d study a risk score for chronic kidney disease can inform choice of hiv medications level of g protein coupled receptor kinase determines myocardial ischemia reperfusion injury via pro and anti apoptotic mechanisms molecule involved in heart failure now implicated in heart attack damage nutritional resilience in nepal following the earthquake of following nepal s devastating earthquake crisis in childhood malnutrition averted designing self propelled chemically active sheets wrappers flappers and creepers self powered microfluidic sheet that wraps flaps and creeps toward phase and catalysis control tracking the formation of intermetallic nanoparticles at atomic scale scientists capture live atomic level detail of nanoparticle formation peripheral blood eosinophilia correlates with hyperplastic nasal polyp growth immune system blood cell a potential marker for sinus polyp regrowth early physical therapy vs usual care in patients with recent onset low back pain benefit of early physical therapy for low back pain appears modest childhood predictors of cardiovascular disease in adulthood. a systematic review and meta analysis childhood obesity causes lasting damage to the body mesenchymal stem cells from human fat engineered to secrete bmp are nononcogenic suppress brain cancer and prolong survival human fat trojan horse to fight brain cancer ? mechanistic framework for cell intrinsic re establishment of pin polarity after cell division plant cells inherit knowledge of where s up and where s down from mother cell neurofilament light protein in blood as a potential biomarker of neurodegeneration in huntington s disease a retrospective cohort analysis blood test can predict onset and track progression of huntington s disease trauma depression and resilience of earthquake tsunami nuclear disaster survivors of hirono fukushima japan japanese town half the survivors of mega earthquake tsunami have ptsd symptoms a high frequency ofbrcamutations in young black women with breast cancer residing in florida young black women have a higher frequency of brca mutations than previously reported adaptive bill morphology for enhanced tool manipulation in new caledonian crows unique beak evolved with tool use in new caledonian crow innovations in capture fisheries are an imperative for nutrition security in the developing world new era of fisheries policy needed to secure nutrition for millions generation and characterization of indoor fungal aerosols for inhalation studies researchers develop realistic system to study impact of residential mold on health genomic characterization of remission in juvenile idiopathic arthritis genomic study reveals why children in remission from rheumatoid arthritis often experience recurrences emotional implications of weight stigma across middle school the role of weight based peer discrimination discrimination toward overweight adolescents predictive of emotional problems direct costs of preventive headache treatments comparison of behavioral and pharmacologic approaches behavioral treatment for migraines a cost effective alternative to meds study finds myosin iia interacts with the spectrin actin membrane skeleton to control red blood cell membrane curvature and deformability healthy red blood cells owe their shape to muscle like structures the effect of coral morphology on shelter selection by coral reef fishes where big fish take shelter has big impact on their ability to cope with climate change urokinase type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke clot dissolver tpa s tardy twin could aid in stroke recovery proximity of snacks to beverages increases food consumption in the workplace a field study distance makes the habits healthier advice on snacking interconnected microbiomes and resistomes in low income human habitats chicken coops sewage treatment plants are hot spots of antibiotic resistance selective co reduction catalyzed by single cobalt sites on carbon nitride under visible light irradiation light activated single ion catalyst breaks down carbon dioxide room for depressed and exhausted mood as a risk predictor for all cause and cardiovascular mortality beyond the contribution of the classical somatic risk factors in men depression as hard on the heart as obesity and cholesterol coffee consumption and the risk of colorectal cancer coffee consumption linked to decreased risk of colorectal cancer risk of venous thromboembolism associated with peripherally inserted central catheters a systematic review and meta analysis commonly used catheters double risk of blood clots in icu and cancer patients a specific missense mutation in gtf i occurs at high frequency in thymic epithelial tumors single gene separates aggressive non aggressive lymphatic system cancer neurophysiological mechanisms of cortical plasticity impairments in schizophrenia and modulation by the nmda receptor agonist d serine hearing deficits in schizophrenia tied to specific brain receptor effect of pneumococcal conjugate vaccination on serotype specific carriage and invasive disease in england a cross sectional study effects of pneumococcal vaccination program on pneumococcal carriage and invasive disease american cancer society colorectal cancer survivorship care guidelines new guidelines address long term needs of colorectal cancer survivors diagnostic thresholds for blood pressure measured at home in the context of the hypertension guideline analysis from us cohorts home monitoring confirms clinic diagnosis of high blood pressure microrna a is strongly downregulated in melanoma and induces cell death through repression of silencer of death domains sodd serendipity points to new potential target and therapy for melanoma an epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state old mice young blood rejuvenating blood of mice by reprogramming stem cells that produce blood influenza a virus infection and cigarette smoke impair bronchodilator responsiveness to adrenoceptor agonists in mouse lung exposure to cigarette smoke and flu virus may prevent lung medications working properly declining bowel cancer incidence and mortality in germany an analysis of time trends in the first ten years after the introduction of screening colonoscopy early detection colorectal cancer rates declining in germany sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan sensitivity to oxidative stress is not always linked to aging study shows topology and ground state degeneracy of tetrahedral smectic vesicles sac with spiral surface patterns facilitate substance delivery antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn examination of antidepressant use in late pregnancy and newborn respiratory disorder sciaphila sugimotoi triuridaceae a new mycoheterotrophic plant from ishigaki island japan new non photosynthesizing plant species discovered on ishigaki island japan herbal medicine treatment reduces inflammation in a murine model of cockroach allergen induced asthma herbal medicine treatment reduces inflammation in allergen induced asthma study suggests timing of angiography and outcomes in high risk patients with non st segment elevation myocardial infarction managed invasively pcsk inhibitor improves outcomes for patients with peripheral artery disease incidence of hiv infection in young gay bisexual and other ymsm health social inequities drives hiv in young men who have sex with other men effect of subjective and objective sleep quality on subsequent peptic ulcer recurrence in older adults the effect of sleep quality on peptic ulcer relapse in older adults this is your portfolio on winter seasonal affective disorder and risk aversion in financial decision making fall market jitters a sad thing less daylight in fall may lead to depressed markets ovarian suppression with triptorelin during adjuvant breast cancer chemotherapy and long term ovarian function pregnancies and disease free survival a randomized clinical trial long term outcomes of preventing premature menopause during chemotherapy rivaroxaban or aspirin for extended treatment of venous thromboembolism new blood thinner better than aspirin at preventing recurrent blood clots decision support for evidence based integration of disease control a proof of concept for malaria and schistosomiasis a simple tool for doubling down on disease control computerized counseling reduces hiv viral load and sexual transmission risk computerized counseling reduces hiv viral load sexual transmission risk adolescent peer relationship qualities as predictors of long term romantic life satisfaction teens same gender friendships key to later satisfaction in romantic relationships is long term bisphosphonate therapy associated with benefits to the periodontium in postmenopausal women ? message to postmenopausal women increase yearly dental checkups researcher urges delineating modern variation from extinct morphology in the fossil record using shells of the eastern box turtle terrapene carolina turtle shells help decode complex links between modern fossil species global leaf trait estimates biased due to plasticity in the shade new leaf study sheds light on shady past generation of transgenic non human primates with germline transmission glowing transgenic monkeys carrying green fluorescent protein gene pave way for new disease models thermodiffusion assisted pyroelectrics enabling rapid and stable heat and radiation sensing a new sensor for light heat and touch understanding autism in the light of sex gender new insights into the male bias of autism new species of pristimantis anura terrarana strabomantinae from lower central america two new frog species discovered in panama s fungal war zone sea spray aerosol as a unique source of ice nucleating particles salty sea spray affects lifetimes of clouds researchers find publishing trends on climate change vulnerability in the conservation literature reveal a predominant focus on direct impacts and long time scales conservation scientists asking wrong questions on climate change impacts on wildlife childhood free time and everyday lives comparing children s views in sweden and the united states children s daily life highly regulated us and swedish differences plant pathogen induced volatiles attract parasitoids to increase parasitism of an insect vector smells like deceit a record number of species use the same odor to exploit each other winter is coming hibernation reverses the outcome of sperm competition in a fly winter season reverses outcome of fruit fly reproduction single photon three dimensional microfabrication through a multimode optical fiber ultra thin optical fibers offer new way to d print microstructures evaluating antibiotic resistance gene correlations with antibiotic exposure conditions in anaerobic membrane bioreactors antibiotic resistance is spreading from wastewater treatment plants ethnic differences in the association between age related macular degeneration and vision specific functioning ethnic differences in effect of age related macular degeneration on visual function the association between out of pocket costs race ethnicity and adjuvant endocrine therapy adherence among medicare breast cancer patients out of pocket costs not ethnicity can explain breast cancer treatment disparities worldviews and trust of sources for health information on electronic nicotine delivery systems effects on risk perceptions and use trust in e cigarette safety varies by worldview source of messaging apc c and scfcyclin f constitute a reciprocal feedback circuit controlling s phase entry scientists discover interplay of yin yang antagonists vital for cell division ebola virus disease in the democratic republic of congo ebola in democratic republic of the congo a new strain of the virus the risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy a systematic review and meta analysis antidepressant drug linked with increased risk of birth defects when taken in early pregnancy chronic burden of near roadway traffic pollution in european cities aphekom network road traffic pollution as serious as passive smoke in the development of childhood asthma the association of trauma center closures with increased inpatient mortality for injured patients trauma center closures linked to higher odds of death for injured patients course of cognitive development from infancy to early adulthood in the psychosis spectrum falling iq scores in childhood may signal psychotic disorders in later life reinstating aberrant mtorc activity in huntington. hexdec. s disease mice improves disease phenotypes animal study points to a treatment for huntington s disease hiv prevention for people with serious mental illness a survey of mental health workers attitudes knowledge and practice sexual health promotion is low among people with serious mental illnesses despite higher risk genetic data reveal a cryptic species of new world flying squirrel glaucomys oregonensis hiding in plain sight new species of flying squirrel discovered switchable car t cells mediate remission in metastatic pancreatic ductal adenocarcinoma killer cell immunotherapy offers potential cure for advanced pancreatic cancer diminishing relative contraindications for immediate breast reconstruction a multicenter study more high risk surgical patients are choosing breast reconstruction procedures after mastectomy uncertainty in forecasts of long run economic growth uncertainty in long run economic growth likely points toward greater emissions climate change costs neural compensation in older people with brain amyloid deposition neural compensation in people with alzheimer s related protein isolation and biological analysis of tumor stem cells from pancreatic adenocarcinoma what is the biological feature of pancreatic adenocarcinoma stem cells ? ammonoid diversity and disparity track episodes of chaotic carbon cycling during the early mesozoic species loss tied to ecosystem collapse and recovery high fat feeding reprograms maternal energy metabolism and induces long term postpartum obesity in mice maternal programming during pregnancy induces long term postpartum obesity a systematic review of recall regimen and maintenance regimen of patients with dental restorations. part tooth borne restorations first clinical practice guidelines call for lifelong maintenance of restored teeth cytotoxic effect of four herbal medicines on gastric cancer ags cell line ziziphora effective in the battle against gastric cancer study suggests three new species of oreophryne anura microhylidae from papua new guinea three new species of tiny frogs from the remarkable region of papua new guinea association of dietary nitrate intake with primary open angle glaucoma higher dietary nitrate green leafy vegetable intake associated with lower risk of glaucoma placental mesenchymal stromal cells rescue ambulation in ovine myelomeningocele prenatal stem cell treatment improves mobility issues caused by spina bifida cardiac mtorc dysregulation impacts stress adaptation and survival in huntington s disease in huntington s disease heart problems reflect broader effects of abnormal protein colony stimulating factor receptor signaling is necessary for microglia viability unmasking a microglia progenitor cell in the adult brain cancer drugs block dementia linked brain inflammation study finds pseudouridylation of trna derived fragments steers translational control in stem cells mechanism vital to keeping blood stem cells functional uncovered hierarchical cultural values predict success and mortality in high stakes teams new research reveals the power of hierarchy in high pressure situations femtosecond valley polarization and topological resonances in transition metal dichalcogenides atomically thin transition metal dichalcogenides could increase computer speed memory by a million times prenatal exposure to cannabis and maternal and child health outcomes a systematic review and meta analysis cannabis use in pregnancy linked to low birthweight and intensive care fear conditioning potentiates synaptic transmission onto long range projection neurons in the lateral subdivision of central amygdala new pathway for fear discovered deep within brain early breast milk exposure modifies brain connectivity in preterm infants breast milk may be best for premature babies brain development tight regulation of memory cd t cells limits their effectiveness during sustained high viral load strengthening fragile immune memories to fight chronic infections fast macro scale transmission imaging of microvascular networks using kesm fast new method for mapping blood vessels may aid cancer research structure of the nucleotide exchange factor eif b reveals mechanism of memory enhancing molecule detailed structure illuminates brain enhancing drug s action shear activated nanoparticle aggregates combined with temporary endovascular bypass to treat large vessel occlusion drug device combination opens potential new path to treat stroke silent hippocampal seizures and spikes identified by foramen ovale electrodes in alzheimer s disease silent seizures recorded in the hippocampus of two patients with alzheimer s disease citizen scientist tagging reveals destinations of migrating monarch butterflies danaus plexippus l. from the pacific northwest monarchs ride west coast winds proof of butterfly migration gathered molecular analyses of neurogenic defects in a human pluripotent stem cell model of fragile x syndrome early brain changes in fragile x syndrome study shows whale shark economics a valuation of wildlife tourism in south ari atoll maldives the maldives and the whale shark world s biggest fish adds value to paradise matrin is essential for fibroblast growth factor dependent maintenance of neural stem cells the protein matrin determines the fate of neural stem cells in brain development shifting habitat mosaics and fish production across river basins hot spots in rivers that nurture salmon flicker on and off in bristol bay region economics of alcohol involved traffic crashes in the usa an input output analysis halving of alcohol fueled car crashes since mid s boosted us economy by billion patients with traumatic brain injury population based study suggests increased risk of stroke traumatic brain injury linked with tenfold increase in stroke risk impacts of climate change on water resources in the mediterranean basin a case study in catalonia spain water flow in mediterranean rivers to fall by percent by the end of the century study predicts putative parapoxvirus associated foot disease in the endangered huemul deer hippocamelus bisulcus in bernardo o higgins national park chile life threatening foot disease found in endangered huemul deer in chile real time aptamer based tracking of circulating therapeutic agents in living animals live feed device monitors drugs in bloodstream in real time seven temperate terrestrial planets around the nearby ultracool dwarf star trappist nasa telescope reveals largest batch of earth size habitable zone planets around single star ligand chirality can affect histidine protonation of vitamin d receptor ab initio molecular orbital calculations in water chirality of vitamin d derivative affects the protonation states of its receptor protein risk of stroke in patients with dengue fever a population based cohort study dengue fever linked to increased risk of stroke dominance in domestic dogs a quantitative analysis of its behavioural measures dominance in a group of dogs expressed in hard figures toward a definition of fresh whole blood an in vitro characterization of coagulation properties in refrigerated whole blood for transfusion whole fresh blood for transfusions may have a longer shelf life than now assumed carbon farming in hot dry coastal areas an option for climate change mitigation could planting trees in the desert mitigate climate change ? pqbp is a proximal sensor of the cgas dependent innate response to hiv research offers a new approach to improving hiv vaccines a gut microbial metabolite of linoleic acid hydroxy cis octadecenoic acid ameliorates intestinal epithelial barrier impairment partially via gpr mek erk pathway microbial metabolite of linoleic acid ameliorates intestinal inflammation hookah smoking among young adults in southern california harmful hookahs many young smokers aren t aware of danger multiplatform evaluation of global trends in wind speed and wave height year study shows increasing ocean winds and wave heights a surviving intact branch stabilizes remaining axon architecture after injury as revealed by in vivo imaging in the mouse spinal cord spinal cord axon injury location determines neuron s regenerative fate spinal injuries in united states military personnel deployed to iraq and afghanistan high rate of spinal injuries among troops deployed to iraq and afghanistan a scenario study of seismically induced landsliding in seattle using broadband synthetic seismograms and accounting for site amplification earthquake triggered landslides pose significant hazard for seattle new study details potential damage survival outcomes after contralateral prophylactic mastectomy a decision analysis marginal life expectancy benefit from contralateral prophylactic mastectomy large scale deployment of seed treatments has driven rapid increase in use of neonicotinoid insecticides and preemptive pest management in u.s. field crops rapid increase in neonicotinoid insecticides driven by seed treatments neonicotinoids may harm pollinators extended pre exposure prophylaxis with lopinavir ritonavir versus lamivudine to prevent hiv transmission through breastfeeding up to weeks in infants in africa anrs a randomised controlled trial breastfeeding babies protected against hiv infection from their hiv positive mothers with months of liquid antiretroviral drug treatment alcohol methamphetamine and marijuana exposure have distinct effects on the human placenta effects of alcohol methamphetamine and marijuana exposure on the placenta alcohol drinking the metabolic syndrome and diabetes in a population with high mean alcohol consumption moderate alcohol consumption lowers the risk of metabolic diseases study suggests effect of maternal and postweaning folic acid supplementation on colorectal cancer risk in the offspring folic acid given to mother rats protects offspring from colon cancer the global epidemiology of syphilis in the past century a systematic review based on antenatal syphilis prevalence a brief history of syphilis points to a neglected disease in sub saharan africa p ry alk expressing cells within the adult human exocrine pancreas are bmp expandable and exhibit progenitor like characteristics unique pancreatic stem cells have potential to regenerate beta cells respond to glucose altering the stability of surface plastic flow via mechanochemical effects design treatment of advanced metals producing better sculpting early life exposure to a herbicide has enduring effects on pathogen induced mortality early life exposure of frogs to herbicide increases mortality from fungal disease food allergy knowledge attitudes and their determinants among restaurant staff a cross sectional study sub optimal food allergy knowledge and attitudes among restaurant staff maternal cigarette smoking is associated with reduced high density lipoprotein cholesterol in healthy year old children smoking during pregnancy lowers levels of good hdl cholesterol in children reliable and practical computational description of molecular crystal polymorphs new computational method reduces risk of drug formulation prevention of soccer related knee injuries in teenaged girls program may prevent knee injuries in young female soccer players hierarchical social networks shape gut microbial composition in wild verreaux s sifaka gut microbiome influenced heavily by social circles in lemurs shaping the body politic mass media fat shaming affects implicit anti fat attitudes celebrity fat shaming has ripple effects on women s implicit anti fat attitudes neurotoxicity of the parkinson s disease associated pesticide ziram is synuclein dependent in zebrafish embryos scientists discover protective strategy against pesticide linked parkinson s disease non invasive imaging biomarker identifies small airway damage in severe copd non invasive imaging technique valid for identifying small airway disease in lung chaperones convert the energy from atp into the nonequilibrium stabilization of native proteins chaperones can hold proteins in non equilibrium states child focused state cash transfers and adolescent risk of hiv infection in south africa a propensity score matched case control study government grants reduce hiv risks for teenage girls in south africa the relationship of sugar to population level diabetes prevalence an econometric analysis of repeated cross sectional data quantity of sugar in food supply linked to diabetes rates researcher says muc b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice experimental findings support a connection between mucins in the lung and pulmonary fibrosis direct observation of von willebrand factor elongation and fiber formation on collagen during acute whole blood exposure to pathological flow new aspect of platelet behavior in heart attacks revealed clots can sense blood flow purification of cardiomyocytes from differentiating pluripotent stem cells using molecular beacons targeting cardiomyocyte specific mrna molecular beacons light path to cardiac muscle repair effects of a home based and volunteer administered physical training nutritional and social support program on malnutrition and frailty in older persons a randomized controlled trial physical training and social support reduce frailty and malnutrition fit for purpose block polymer membranes molecularly engineered for water treatment engineered polymer membranes could be new option for water treatment multilayer dielectric elastomers for fast programmable actuation without prestretch artificial muscle for soft robotics low voltage high hopes poverty alleviation strategies in eastern china lead to critical ecological dynamics large scale study warns of unsustainable ecological decline in rural china transgenic mice convert carbohydrates to essential fatty acids transgenic mice produce both omega omega fatty acids on carbohydrate diet effects of particle size on chemical speciation and bioavailability of copper to earthworms exposed to copper nanoparticles earthworms absorb discarded copper nanomaterials present in soil impact of time of presentation on process performance and outcomes in st segment elevation myocardial infarction a report from the american heart association mission lifeline program time of arrival at hospital impacts time to treatment and survival of heart attack patients evidence for increased behavioral control by punishment in children with attention deficit hyperactivity disorder ouch ! avoiding failure leads to missed opportunities for children with adhd reconciling after civil conflict increases social capital but decreases individual well being post conflict reconciliation led to societal healing but worsened psychological health impacts of urban carbon dioxide emissions on sea air flux and ocean acidification in nearshore waters carbon dioxide from silicon valley affects the chemistry of monterey bay population based incidence rates of cervical intraepithelial neoplasia in the human papillomavirus vaccine era hpv vaccine reduces cervical pre cancers in young women new research shows neural and behavioral correlates of sacred values and vulnerability to violent extremism neuroimaging shows social exclusion spurs extremism in those vulnerable to radicalization evidence for differences in immunologic and pathogenesis properties of herpes simplex virus strains from the united states and south africa genital herpes more virulent in africa than in us report finds super enhancers delineate disease associated regulatory nodes in t cells link between powerful gene regulatory elements and autoimmune diseases taking the heat thermoregulation in asian elephants under different climatic conditions taking the heat asian elephants simply ride out high daytime heat load metal contaminated potato crops and potential human health risk in bolivian mining highlands metals from bolivian mines affect crops and pose potential health risk study suggests reversal of cognitive decline in alzheimer s disease pre and post testing show reversal of memory loss from alzheimer s disease in patients edge functionalized g c n nanosheets as a highly efficient metal free photocatalyst for safe drinking water green water purification system works without heavy metals or corrosive chemicals association between agent orange exposure and nonmelanotic invasive skin cancer agent orange linked to skin cancer risk report suggests program interruptions and short stay transfers represent potential targets for inpatient rehabilitation care improvement efforts interruptions to rehab are common after stroke or brain injury but many are preventable health insurance alcohol and tobacco use among pregnant and non pregnant women of reproductive age health insurance coverage is associated with lower odds of alcohol use by pregnant women myd signaling in t cells directs iga mediated control of the microbiota to promote health immune system promotes digestive health by fostering community of good bacteria delivery outcomes for nulliparous women at the extremes of maternal age a cohort study younger mothers and older mothers are at higher risk of adverse delivery outcomes the parasite s long arm a tapeworm parasite induces behavioural changes in uninfected group members of its social host parasitic tapeworm influences behavior and lifespan of uninfected members of ant colonies parental care in the cuatro ci negas cichlid herichthys minckleyi teleostei cichlidae fish uses sneaking behavior as stealth mating strategy antagonistic actions of msx and osr pattern mammalian teeth into a single row scientists discover why teeth in mammals but not sharks form in a single row guidelines for the standardization of preanalytic variables for blood based biomarker studies in alzheimer s disease research guidelines for clinical trials of alzheimer s blood test ni revealed as a doubly magic stronghold against nuclear deformation nuclear magic numbers collapse beyond the doubly magic nickel bones body parts and sex appeal an analysis of thinspiration images on popular social media images of extremely thin women on social media sites herpes simplex virus type i dna is located within alzheimer s disease amyloid plaques cold sore virus linked to alzheimer s disease new treatment or even vaccine possible adulteration of proprietary chinese medicines and health products with undeclared drugs experience of a tertiary toxicology laboratory in hong kong adulteration of proprietary chinese medicines and health products poses severe health risks injury pain and prescription opioid use among former nfl football players retired nfl players misuse painkillers more than general population study finds limited hatchery introgression into wild brook trout salvelinus fontinalis populations despite reoccurring stocking few hatchery brook trout genes present in pennsylvania watershed wild fish receptor activation in the mushroom bodies rescues sleep loss induced learning brain tweak lets sleep deprived flies stay sharp publisher correction medial preoptic circuit induces hunting like actions to target objects and prey animal cyborg behavioral control by toy craving circuit longitudinal analysis of music education on executive functions in primary school children music lessons improve children s cognitive skills and academic performance maternal uniparental disomy of chromosome a novel imprinting disorder of growth failure new genetic disorder named for children s hospital of philadelphia team autologous hematopoietic stem cell transplantation in multiple sclerosis a phase ii trial stem cell transplants may work better than existing drug for severe multiple sclerosis ceramic metal composites for heat exchangers in concentrated solar power plants new material manufacturing process use sun s heat for cheaper renewable electricity inhibition of glycosphingolipid synthesis ameliorates atherosclerosis and arterial stiffness in apo e mice and rabbits fed a high fat and cholesterol diet fat metabolism in animals altered to prevent most common type of heart disease synthetic antibodies with a human framework that protect mice from lethal sudan ebolavirus challenge drug shows promise against sudan strain of ebola in mice unearthing the fossorial tadpoles of the indian dancing frog family micrixalidae indian dancing frog s secretive tadpoles unearthed from sand beds young adult smokers neural response to graphic cigarette warning labels graphic cigarette warnings trigger brain areas key to quitting smoking a high fat diet and nad activate sirt to rescue premature aging in cockayne syndrome high fat diet postpones brain aging in mice hybrid spect perfusion imaging and coronary ct angiography long term prognostic value for cardiovascular outcomes cardiac hybrid imaging an effective tool for predicting heart attacks incomplete host immunity favors the evolution of virulence in an emergent pathogen in nature an imperfect immune system drives the evolution of deadly pathogens vitamin d and the omega fatty acids control serotonin synthesis and action part relevance for adhd bipolar schizophrenia and impulsive behavior omega fatty acids vitamin d may control brain serotonin affecting behavior and psychiatric disorders safety and effectiveness of longer term phentermine use clinical outcomes from an electronic health record cohort generic weight loss drug may be safe and effective for long term treatment feeding behavior by hummingbirds aves trochilidae in artificial food patches in an atlantic forest remnant in southeastern brazil feeding strategies in competing hummingbird species observed in a small area in brazil barriers and facilitators to successful transition from long term residential substance abuse treatment challenges in going from residential substance abuse treatment to the community quantifying the benefit of early climate change mitigation in avoiding biodiversity loss climate change will cause widespread global scale loss of common plants and animals researchers predict early neurogenomic response associated with variation in guppy female mate preference small brained female guppies aren t drawn to attractive males rediscovery of red wolf ghost alleles in a canid population along the american gulf coast a future for red wolves may be found on galveston island texas physicians political preferences and the delivery of end of life care in the united states retrospective observational study do democrat and republican doctors treat patients differently at the end of life ? interaction of theadrb gene polymorphism with childhood trauma in predicting adult symptoms of posttraumatic stress disorder evidence of genetic link to ptsd in soldiers exposed to childhood trauma siderophore inspired chelator hijacks uranium from aqueous medium bio inspired material targets oceans uranium stores for sustainable nuclear energy multicenter prospective cohort study of the incidence of adverse events associated with cosmetic dermatologic procedures safest cosmetic surgery procedures national study offers broad evidence of safety for minimally invasive procedures positive impact of cladribine on quality of life in people with relapsing multiple sclerosis data revealed under foi shows benefits of ms drug currently blocked by regulators conspicuous male coloration impairs survival against avian predators in aegean wall lizards podarcis erhardii love s labors study shows male lizards risk becoming lunch for a bird to attract a mate factors that affect skin aging a cohort based survey on twins twin study identifies factors associated with skin aging the world s largest high arctic lake responds rapidly to climate warming c rise in atmospheric temperature causes rapid changes to world s largest high arctic lake a pilot study evaluating the effectiveness of platelet rich plasma therapy for treating degenerative tendinopathies a randomized control trial with synchronous observational cohort platelet rich plasma injections may lead to improvements in tissue healing posterior spinal artery aneurysm rupture after ecstasy abuse burst spinal artery aneurysm linked to ecstasy use generation of three dimensional multiple spheroid model of olfactory ensheathing cells using floating liquid marbles another dimension d cell growth opens new pathway for spinal cord repair survival of mussels in extremely acidic waters on a submarine volcano ocean acidification understanding how mussels have adapted to extremely acidic waters near underwater volcanoes biogenic silica production and diatom dynamics in the svalbard region during spring new dataset expands understanding of arctic spring bloom the knight and the king two new species of giant bent toed gecko cyrtodactylus gekkonidae squamata from northern new guinea with comments on endemism in the north papuan mountains the scaled king and his knight two new giant bent toed gecko species from new guinea spouses of stroke survivors report reduced health related quality of life even in long term follow up spouses of stroke survivors face lingering health issues sleep dependent enhancement of emotional memory in early childhood research finds naps plus sleep may enhance emotional memory in early childhood vestibular stimulation improves insight into illness in schizophrenia spectrum disorders balance test improves insight into illness in schizophrenia antibodies to apolipoprotein a i high density lipoprotein and c reactive protein are associated with disease activity in patients with systemic lupus erythematosus antibodies linked to cardiovascular disease increase in patients with active lupus genetic and functional analyses of shank mutations suggest a multiple hit model of autism spectrum disorders further support for a role of synaptic proteins in autism spectrum disorders oral administration of a new hri activator as a new strategy to improve high fat diet induced glucose intolerance hepatic steatosis and hypertriglyceridemia through fgf a new molecule to fight type diabetes and non alcoholic fatty liver disease genetic variants in one carbon metabolism genes and breast cancer risk in european american and african american women analysis of key breast cancer genes reveals distinct profiles for african american european american women the magnitude. tohoku oki earthquake mosaicking the megathrust from seconds to centuries japan s. tohoku oki earthquake surprising findings about energy distribution over fault slip and stress accumulation diverging longitudinal changes in astrocytosis and amyloid pet in autosomal dominant alzheimer s disease inflammatory changes in the brain twenty years before alzheimer onset a social ecological analysis of community perceptions of dengue fever and aedes aegypti in machala ecuador new information on climate drivers of dengue fever discovered adjuvant chemotherapy with gemcitabine and long term outcomes among patients with resected pancreatic cancer chemotherapy drug improves survival following surgery for pancreatic cancer a widespread family of polymorphic contact dependent toxin delivery systems in bacteria mortal chemical combat typifies the world of bacteria preexposure chemoprophylaxis for hiv prevention in men who have sex with men antiretroviral drugs can prevent hiv in men who have sex with men study shows we need smarter trigger tools for diagnosing sepsis in children in canada smart technology to help diagnose sepsis in children in canada air quality and climate benefits of long distance electricity transmission in china could renewable power by wire help fix china s air pollution problems ? on the unsteadiness of shock laminar boundary layer interactions of hypersonic flows over a double cone simulating hypersonic flow transitions from smooth to turbulent aggregatibacter actinomycetemcomitans induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis researchers add to evidence that common bacterial cause of gum disease may drive rheumatoid arthritis epidemiology of injuries in first division spanish football injuries of professional soccer players twelve times more frequent in competition than during training sessions ? androgen deprivation therapy and future alzheimer s disease risk testosterone lowering therapy for prostate cancer may increase alzheimer s risk prospective randomized trial to assess effects of continuing hormone therapy on cerebral function in postmenopausal women at risk for dementia estradiol preserves key brain regions in postmenopausal women at risk for dementia the prognostic significance of respiratory rate in patients with pneumonia a retrospective analysis of data from hospitalized patients in germany from prognosis of pneumonia value of respiratory rate often overlooked factors associated with occupational sun protection policies in local government organizations in colorado occupational sun safety policies examined for local government workers in colorado hexosamine biosynthetic pathway mutations cause neuromuscular transmission defect new gene test offers personalized treatment for inherited neuromuscular disorder opposite effects of microchimerism on breast and colon cancer presence of fetal cells in women lowers risk of breast cancer but raises risk of colon cancer associations of partnering transition and socioeconomic status with a four year change in daily steps among finnish adults a change in marital status affects the number of daily steps oxygen isotopes of east asian dinosaurs reveal exceptionally cold early cretaceous climates chilly times for chinese dinosaurs abundance of feathered dinosaurs during temperate climate with harsh winters the impact of socioeconomic status on stage of cancer at diagnosis and survival a population based study in ontario canada socioeconomic status predicts survival of canadian cancer patients corticospinal circuits from the sensory and motor cortices differentially regulate skilled movements through distinct spinal interneurons scientists map key brain to spinal cord nerve connections for voluntary movement long term outcomes of lumbar spinal stenosis eight year results of the spine patient outcomes research trial sport after eight years similar outcomes with surgical or nonsurgical treatment for spinal stenosis family context moderates the association of maternal postpartum depression and stability of infant temperament family factors may influence a child s temperament digital forms of dating violence what school nurses need to know digital forms of dating violence are on the rise what school nurses need to know rain predators and spider sociality a manipulative experiment survival instinct not family bonds weave massive spider colonies together randomized controlled trial of yoga in women with breast cancer undergoing radiotherapy yoga regulates stress hormones improves quality of life for women with breast cancer undergoing radiation therapy association of hdl cholesterol efflux capacity with incident coronary heart disease events a prospective case control study study links better good cholesterol function with lower risk of later heart disease adherence to antiretroviral prophylaxis for hiv prevention a substudy cohort within a clinical trial of serodiscordant couples in east africa high adherence to hiv prophylaxis may raise efficacy for couples where one partner has hiv synchronized personalized music audio playlists to improve adherence to physical activity among patients participating in a structured exercise program a proof of principle feasibility study new music strategy shows per cent increase in exercise adherence association of metformin use with risk of lactic acidosis across the range of kidney function common diabetes drug found safe for most diabetics with kidney disease a potent epha agonistic peptide drug conjugate reduces circulating cancer cells and metastases in breast cancer models molecular trojan horse delivers chemotherapeutic drug to cancer cells defining a therapeutic target for pallidal deep brain stimulation for dystonia d computer model may help refine target for deep brain stimulation therapy for dystonia probiotic bacteria reduce salmonella typhimurium intestinal colonization by competing for iron probiotic bacterium lessens severity of salmonella infections by hoarding iron hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury randomized prospective trial new hope for victims of traumatic brain injury tuberculosis in uk prisoners a challenge for control high rates of drug resistant tb among uk prisoners digital mammography screening does age influence the detection rates of low intermediate and high grade ductal carcinoma in situ ? high grade dcis detection rates increase in older women moving climate change beyond the tragedy of the commons turning climate change from a tragedy of the commons to positive action improving reintroduction success in large carnivores through individual based modelling how to reintroduce eurasian lynx lynx lynx to scotland proposed reintroduction of the eurasian lynx to scotland cardiovascular risk factors in hematopoietic cell transplantation hct survivors role in development of subsequent cardiovascular disease stem cell transplant survivors at increased risk of developing heart disease study suggests a new research and development policy framework for the biomedical research enterprise biomedical research policy needed for therapies economic growth education and security negative effects of long duration spaceflight on paraspinal muscle morphology long duration space missions have lasting effects on spinal muscles dementia and physical activity dapa trial of moderate to high intensity exercise training for people with dementia randomised controlled trial moderate to high intensity exercise does not slow cognitive decline in people with dementia study finds establishing spatial and temporal patterns in microcystis sediment seed stock viability and their relationship to subsequent bloom development in western lake erie lake erie algal blooms seeded internally by overwintering cells in lake bottom sediments leaders benefit followers in the collective movement of a social sawfly follow the leader insects benefit from good leadership too deficits in adult neurogenesis contextual fear conditioning and spatial learning in a gfap mutant mouse model of alexander disease rare disease yields clues about broader brain pathology predicting range shifts of asian elephants under global change asian elephants may lose up to percent of suitable habitats in india and nepal clinical psychologists implementation of the mental capacity act crucial decisions often taken with poor guidance for those with limited mental capacity increased prevalence of celiac disease in patients with unexplained infertility in the united states increased celiac disease prevalence in women with unexplained infertility molecular modulation of airway epithelial ciliary response to sneezing allergies ? your sneeze is a biological response to the nose s blue screen of death tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia a dose finding study erectile dysfunction drug shows promise for relief of lower urinary tract symptoms associated with benign prostate disease a plasmid from an antarctic haloarchaeon uses specialized membrane vesicles to disseminate and infect plasmid free cells antarctic salt loving microbes provide insights into evolution of viruses high occurrence of mood and anxiety disorders among older adults the national comorbidity survey replication mood and anxiety disorders affect many older adults mutational history of a human cell lineage from somatic to induced pluripotent stem cells test run finds no cancer risk from stem cell therapy control of growth hormone and igf in patients with acromegaly in the uk responses to medical treatment with somatostatin analogues and dopamine agonists drugs fail to meet hormone targets in control of rare growth disorder primary prevention of cervical cancer american society of clinical oncology resource stratified guideline first global guidance for hpv vaccination for cervical cancer prevention cardiovascular events after clarithromycin use in lower respiratory tract infections analysis of two prospective cohort studies common antibiotic linked to heart problems in patients with lung conditions failed recovery of glycemic control and myofibrillar protein synthesis with wk of physical inactivity in overweight prediabetic older adults just two weeks inactivity can trigger diabetic symptoms in vulnerable patients parenting and salience network connectivity among african americans a protective pathway for health risk behaviors childhood communication enhances brain development protecting against harmful behaviors hybridization reveals the evolving genomic architecture of speciation butterflies show origin of species as an evolutionary process not a single event regional specificity of gabaergic regulation of cross modal plasticity in mouse visual cortex after unilateral enucleation brain plasticity after vision loss has an on off switch genome wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell cycle regulatory genes in diffuse intrinsic pontine glioma key regulatory genes often amplified in aggressive childhood tumor of the brainstem difference in differences analysis of the association between state same sex marriage policies and adolescent suicide attempts state same sex marriage policies associated with reduced teen suicide attempts dietary patterns and the risk of major adverse cardiovascular events in a global study of high risk patients with stable coronary heart disease your weight as a teenager is linked to your risk of heart failure in early middle age autism recurrence in half siblings strong support for genetic mechanisms of transmission in asd study of half siblings provides genetic clues to autism interleukin supplementation improves the pathophysiology of hypertension in response to placental ischemia in rupp rats better regulation of the immune system may minimize preeclampsia symptoms survival in braf v mutant advanced melanoma treated with vemurafenib newly approved drug for metastatic melanoma nearly doubles median survival golden bananas in the field elevated fruit pro vitamin a from the expression of a single banana transgene golden bananas high in pro vitamin a developed rapid innate defensive responses of mice to looming visual stimuli look out above experiment explores innate visual behavior in mice timing of first postdischarge follow up and medication adherence after acute myocardial infarction longer time to follow up with patients after heart attack associated with worse medication adherence foliar microbiome transplants confer disease resistance in a critically endangered plant microbiome transplants provide disease resistance in critically endangered hawaiian plant large phaeodaria in the twilight zone their role in the carbon cycle in the ocean s twilight zone tiny organisms may have giant effect on earth s carbon cycle internet blogs polar bears and climate change denial by proxy polar bear blogs reveal dangerous gap between climate change facts and opinions acute solar retinopathy imaged with adaptive optics optical coherence tomography angiography and en face optical coherence tomography solar eclipse using adaptive optics to understand eye damage low dose irradiation enhances gene targeting in human pluripotent stem cells using low dose irradiation researchers can now edit human genes comparing the contributions of acute and postacute care facility characteristics to outcomes after hospitalization for hip fracture hip fracture patients fare best during recovery in high occupancy nursing homes with higher level physician staffing enhancer hijacking activates gfi family oncogenes in medulloblastoma cancer by remote control overlooked dna shuffling drives deadly paediatric brain tumour cross species amplifiable microsatellite markers for neoverrucid barnacles from deep sea hydrothermal vents developed using next generation sequencing hydrothermal settlers barnacle holds clues about how climate change is affecting the deep ocean generation of bimaternal and bipaternal mice from hypomethylated haploid escs with imprinting region deletions mouse pups with same sex parents born in china using stem cells and gene editing disorganized gyrification network properties during the transition to psychosis brain folding provides researchers with an accurate marker to predict psychosis usp contributes to somatic stem cell defects in down s syndrome faulty stem cell regulation may contribute to cognitive deficits associated with down syndrome social emotional learning program to reduce bullying fighting and victimization among middle school students with disabilities bullying by students with disabilities reduced by social emotional learning distance dependent defensive coloration in the poison frogdendrobates tinctorius dendrobatidae bright warning colors on poison dart frogs also act as camouflage new science in plain sight citizen scientists lead to the discovery of optical structure in the upper atmosphere mystery of purple lights in sky solved with help from citizen scientists a diamond in the rough desert shrublands of the great basin in the western united states a new cryptic toad species amphibia bufonidae bufo anaxyrus discovered in northern nevada rare discovery of three new toad species in nevada s great basin effects of liraglutide on clinical stability among patients with advanced heart failure and reduced ejection fraction drug does not improve outcomes for patients with advanced heart failure the chondrocyte clock gene bmal controls cartilage homeostasis and integrity body clock study unlocks prospect of treatment for osteoarthritis out of pocket spending and financial burden among medicare beneficiaries with cancer medicare beneficiaries face high out of pocket costs for cancer treatment harsh parenting and food insecurity in adolescence the association with emerging adult obesity harsh parenting food insecurity predicts obesity for young women h.e.s.s. phase i observations of the plane of the milky way the largest catalog ever published of very high energy gamma ray sources in the galaxy a complex baleen whale call recorded in the mariana trench marine national monument new complex call recorded in mariana trench believed to be from baleen whale impact of hypertension on cognitive function a scientific statement from the american heart association high blood pressure can impair cognitive function pose risk for alzheimer s embryonic stem cell derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction stem cell exosomes used to induce damaged mouse hearts to self repair randomised controlled trials for ebola practical and ethical issues insisting only on randomized controlled trials for ebola treatments unethical impractical say leading health experts enhanced surveillance for rift valley fever in livestock during el ni o rains and threat of rvf outbreak kenya surveillance of livestock could detect rift valley fever disease before human transmission the relationship between reticulated platelets intestinal alkaline phosphatase and necrotizing enterocolitis risk factor identified for life threatening disease in preemies two distinct pools of b analogs reveal community interdependencies in the ocean vitamin b and a knockoff version create complex market for marine vitamins adversity before conception will affect adult progeny in rats. trauma experienced by a mother even before pregnancy will influence her offspring s behavior safety and efficacy in children of an sq standardized grass allergen tablet for sublingual immunotherapy immunotherapy alleviates hay fever and asthma in children study finds widespread triploidy in western north american aspen populus tremuloides western aspen trees commonly carry extra set of chromosomes association of state dense breast notification laws with supplemental testing and cancer detection after screening mammography breast ultrasound and cancer detection rates increased under new laws mast cell histamine promotes the immunoregulatory activity of myeloid derived suppressor cells is the next new cancer drug already in your medicine cabinet ? antihistamines may have anti cancer properties acute axonal degeneration drives development of cognitive motor and visual deficits after blast mediated traumatic brain injury in mice potential target identified for preventing long term effects of traumatic brain injury symptom report in detecting breast cancer related lymphedema method for detecting latent stage of lymphedema identified generation of induced pluripotent stem cell lines from tibetan miniature pig engineered pig stem cells bridge the mouse human gap guillain barr syndrome outbreak associated with zika virus infection in french polynesia a case control study zika virus might cause guillain barr syndrome according to new evidence residual effects young adult diagnostic drinking predicts late life health outcomes young adults problem drinking may have lasting health effects environmental views from the coast public concern about local to global marine issues from sea to shining sea politics divide coastal residents views of environment footwear characteristics and factors influencing footwear choice in patients with gout poor footwear linked to foot impairment and disability in gout patients host shifts result in parallel genetic changes when viruses adapt to closely related species viruses can evolve in parallel in related species historical rise of waterpower initiated the collapse of salmon stocks medieval water power initiated collapse of salmon stocks reorganizational healing a paradigm for the advancement of wellness behavior change holistic practice and healing reorganizational healing model puts emphasis on self awareness and personal will endoscopic molecular imaging of human bladder cancer using a cd antibody new molecular imaging technology could improve bladder cancer detection uterine cancer after risk reducing salpingo oophorectomy without hysterectomy in women withbrcamutations women with brca gene mutation at higher risk of deadly uterine cancer a tissue engineered scale model of the heart ventricle a d model of a human heart ventricle capacity of and demand for neonatal nurse practitioner educational programs a missing piece of the workforce puzzle interest in child specific nurse practitioner programs dwindling despite strong job market for graduates bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction bone marrow fat tissue secretes hormone that helps body stay healthy fate of ipscs derived from azoospermic and fertile men following xenotransplantation to murine seminiferous tubules stem cells from some infertile men form germ cells when transplanted into mice prospective investigation of autism and genotype phenotype correlations in q deletion syndrome and shank deficiency first comprehensive and prospective characterization of a genetic subtype of autism loss of dopamine d receptors induces atrophy in the temporal and parietal cortices and the caudal thalamus of ethanol consuming mice drinking alcohol shrinks critical brain regions in genetically vulnerable mice identification of vulnerable cell types in major brain disorders using single cell transcriptomes and expression weighted cell type enrichment gene study points towards therapies for common brain disorders dual targeting nanoparticle stimulates the immune system to inhibit tumor growth first dual targeting nanoparticles lower cancer s defenses and attack tumors oral health promoting school environments and dental caries in qu bec children better food choices near schools for healthier teeth association between periodontitis and mortality in stages chronic kidney disease nhanes iii and linked mortality study periodontitis linked to a higher mortality rate in patients with kidney disease chronic intranasal oxytocin causes long term impairments in partner preference formation in male prairie voles a cautionary note on oxytocin as a treatment for psychiatric disorders pregnancy loss and risk of cardiovascular disease a prospective population based cohort study epic heidelberg recurrent miscarriage raises heart attack risk fivefold in later life study finds neonothopanus gardneri a new combination for a bioluminescent agaric from brazil mushroom lights up the night in brazil researcher finds bioluminescent fungus not seen since how well do you see what you hear ? the acuity of visual to auditory sensory substitution how well can you see with your ears ? device offers new alternative to blind people dissemination of ndm positive bacteria in the new delhi environment and its implications for human health an environmental point prevalence study antibiotic resistant bacteria in indian public water supply periodontal disease and incident cancer risk among postmenopausal women results from the women s health initiative observational cohort history of gum disease increases cancer risk in older women enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic h n influenza gastrointestinal absorption of tamiflu in critically ill patients with h n early life experiences and social cognition in major psychiatric disorders a systematic review childhood trauma linked to impaired social cognition later in life for patients with major psychiatric disorders contemporary climate change in the sonoran desert favors cold adapted species warming climate chills sonoran desert s spring flowers study of the flying ability of rhynchophorus ferrugineus coleoptera dryophthoridae adults using a computer monitored flight mill researchers study flight pattern of red palm weevil in order to set more efficient control measures radial growth response to climate change along the latitudinal range of the world s southernmost conifer in southern south america populations of widely spread tree species respond differently to climate change trp channel regulates egfr signaling in hair morphogenesis and skin barrier formation cellular channel may open doors to skin conditions hair growth risk of bleeding with dabigatran in atrial fibrillation higher risk of bleeding in atrial fibrillation patients taking blood thinner dabigatran impact of antisocial lifestyle on health chronic disability and death by middle age delinquent boys at increased risk of premature death and disability by middle age collapse of classic maya civilization related to modest reduction in precipitation classic maya civilization collapse related to modest rainfall reductions research suggests motor skills and calibrated autism severity in young children with autism spectrum disorder motor skill deficiencies linked to autism severity reseearch says discovery of a sensory organ that coordinates lunge feeding in rorqual whales a whale of a discovery new sensory organ found in rorqual whales myths facts and conditional truths what is the evidence on the risks associated with smoking in cars carrying children ? risks associated with second hand smoke in cars carrying children genomic characterization of a south american phytophthora hybrid mandates reassessment of the geographic origins of phytophthora infestans south american origins and spread of irish potato famine pathogen declining water yield from forested mountain watersheds in response to climate change and forest mesophication water yields from southern appalachian watersheds in decline since the s externally driven changes in the abundance of summer and winter flounder distribution of fish on northeast us shelf influenced by both fishing climate cellular milieu imparts distinct pathological synuclein strains in synucleinopathies diverse parkinson s related disorders may stem from different strains of same protein zoonotic transmission of two new strains of human t lymphotropic virus type in hunters bitten by a gorilla in central africa discovery of new strains of the htlv virus in hunters bitten by gorillas in gabon adiposity in childhood brain tumors a report from the canadian study of determinants of endometabolic health in children candecide study survivors of childhood brain tumors have increased body fat a role for miro in motility and membrane dynamics of peroxisomes pulling power reveals new insights into membrane dynamics in human cells improving maternal mental health after a child s diagnosis of autism spectrum disorder problem solving education reduces parental stress after child autism diagnosis a genome wide association study of kynurenic acid in cerebrospinal fluid implications for psychosis and cognitive impairment in bipolar disorder possible mechanism for specific symptoms in bipolar disorder discovered anger in the context of postnatal depression an integrative review anger overlooked as feature of postnatal mood disorders comparative genomics reveals convergent rates of evolution in ant plant mutualisms ant genomics declare checkmate to red king theory long standing scientific theory challenged association of chronic low grade inflammation with risk of alzheimer disease in apoe carriers link found between chronic inflammation and risk for alzheimer s disease circadian clock involvement in zooplankton diel vertical migration genetic clocks in zooplankton species regulate what is likely the largest daily movement of biomass worldwide a transiting exocomet detected in broadband light by tess in the pictoris system three exocomets discovered around the star beta pictoris screening pelvic examination in adult women a clinical practice guideline from the american college of physicians acp recommends against pelvic exam in asymptomatic average risk non pregnant women male circumcision at different ages in rwanda a cost effectiveness study circumcising newborn males is a cost effective strategy for hiv prevention in rwanda study finds mapping of the primary mannose binding site of pradimicin a undoing hiv s invisibility cloak revelation of how certain compounds adhere so strongly to hiv s coat points to a fresh therapeutic approach genetic architecture and evolution of the s locus supergene in primula vulgaris flower forms in the primrose biologists unlock. million year old genetic secret to landmark darwin theory new light on exposure to chemicals and cardiovascular diseases workplace exposure to pesticides and metals linked to heightened heart disease risk startle potentiation to uncertain threat as a psychophysiological indicator of fear based psychopathology an examination across multiple internalizing disorders. fear of the unknown common to many anxiety disorders rule learning enhances structural plasticity of long range axons in frontal cortex scientists tap the smarts of mice capture problem solving in action media exposure and sympathetic nervous system reactivity predict ptsd symptoms after the boston marathon bombings media exposure sympathetic nervous system reactivity predict ptsd symptoms in adolescents multiplexed d super resolution imaging of whole cells using spinning disk confocal microscopy and dna paint visualizing single molecules in whole cells with a new spin hollow carbon spheres in microwaves bio inspired absorbing coating antireflective coating sugar based carbon hollow spheres that mimic moth eyes deception of trans fats on food and drug administration food labels a proposed revision to the presentation of trans fats on food labels call for truth in trans fats labeling by us fda study shows how deceptive food labels lead to increased risk of deadly diseases interferon gamma regulates intestinal epithelial homeostasis through converging beta catenin signaling pathways feedback loop explains inflammatory effect on intestinal lining the gender divide the impact of surgeon gender on surgical practice patterns in urology the gender divide in urology surgeon gender shapes the clinical landscape a corticotropin releasing factor system expressed in the cochlea modulates hearing sensitivity and protects against noise induced hearing loss stress response system in the ear protects against hearing loss association of childhood adversities and early onset mental disorders with adult onset chronic physical conditions childhood adversities and early onset mental disorders associated with higher rates of chronic physical problems in adulthood cell associated heparin like molecules modulate the ability of ldl to regulate pcsk uptake study sheds light on the function of a long mysterious pcsk mutation close friendship strength and broader peer group desirability as differential predictors of adult mental health close friendships in high school predict improvements in mental health in young adulthood new microbe genomic variants in patients fecal community following surgical disruption of the upper human gastrointestinal tract obesity surgery leads to emergence of new microbial strains in the human fecal community are dispensaries indispensable ? patient experiences of access to cannabis from medical cannabis dispensaries in canada don t dispense of cannabis dispensaries caution researchers can patient experience with service quality predict survival in colorectal cancer ? patient satisfaction with clinical services can affect treatment outcomes maximizing tendencies in marriage accentuating the implications of readily observable partner characteristics for intimates satisfaction for some people attractive wives and high status husbands enhance marital quality assessing the relative contribution of economic political and environmental factors on past conflict and the displacement of people in east africa climate change not the key driver of human conflict and displacement in east africa pd blockade induces responses by inhibiting adaptive immune resistance why patients respond to a life saving melanoma drug the antibacterial activity of acetic acid against biofilm producing pathogens of relevance to burns patients acetic acid found in vinegar shown to be effective against bacteria found in burn wounds extending the treatment options in alcohol dependence a randomized controlled study of as needed nalmefene new treatment option for alcohol dependence reduced consumption rather than abstinence factors influencing wild chimpanzee pan troglodytes verus relative abundance in an agriculture swamp matrix outside protected areas chimpanzees at the crossroads adapt to living outside protected areas the current health of the signing deaf community in the uk compared with the general population a cross sectional study poor access to primary care results in poorer health for deaf people trauma surge index advancing the measurement of trauma surges and their influence on mortality scoring system can help trauma centers improve care during surges in trauma cases atp directed capture of bioactive herbal based medicine on human trna synthetase chinese medicine yields secrets atomic mechanism of two headed molecule derived from chang shan a traditional chinese herb anti microbial pomegranate rind extracts enhancement by cu ii and vitamin c combinations against clinical isolates of pseudomonas aeruginosa pomegranates latest weapon in the fight against mrsa spatial and temporal variability in hawaiian hotspot volcanism induced by small scale convection hawaiian hotspot variability attributed to small scale convection easl clinical practice guidelines management of hepatitis c virus infection revised clinical practice guidelines to optimize management of hepatitis c loggerhead turtles caretta caretta use vision to forage on gelatinous prey in mid water turtles watch for snack on gelatinous prey while swimming neural development is dependent on the function of specificity protein in cell cycle progression lack of protein sp disrupts neuron creation in brain whole exome sequencing in early onset cerebral sle identifies a pathogenic variant in trex genetic key to lupus shows potential of personalized medicine lithium storage mechanisms in purpurin based organic lithium ion battery electrodes ancient red dye powers new green battery chemists use plant extract in eco friendly sustainable lithium ion battery the genome of a tortoise herpesvirus testudinid herpesvirus has a novel structure and contains a large region that is not required for replicationin vitroor virulencein vivo major step towards a vaccine against a lethal disease that kills endangered tortoises one step optogenetics with multifunctional flexible polymer fibers tiny fibers open new windows into the brain delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke compound derived from curry spice is neuroprotective against stroke and traumatic brain injury basic need satisfaction in the parental relationship offsets millennials worries about the transition to college parental support linked to how well millennials transition to college life development of biodegradable foamlike materials based on casein and sodium montmorillonite clay biodegradable foam plastic substitute made from milk protein and clay millennial scale northern hemisphere atlantic pacific climate teleconnections in the earliest middle pleistocene rapid climate changes across northern hemisphere in the earliest middle pleistocene platelet transfusions in platelet consumptive disorders are associated with arterial thrombosis and in hospital mortality platelet transfusions increase odds of death in some rare blood cell disorders the day after effect long term hebbian like restructuring of resting state fmri patterns induced by a single epoch of cortical activation past brain activation revealed in scans brain activity patterns preserve traces of previous cognitive activity one minute of marijuana secondhand smoke exposure substantially impairs vascular endothelial function a minute of secondhand marijuana smoke may damage blood vessels study in rats visual rehabilitation training alters attentional networks in hemianopia an fmri study attention network plays key role in restoring vision after brain damage dysregulation in microrna expression is associated with alterations in immune functions in combat veterans with post traumatic stress disorder inflammation in those with ptsd linked to changes in microrna three year follow up results of photodynamic therapy vs. imiquimod vs. fluorouracil for treatment of superficial basal cell carcinoma a single blind noninferiority randomized controlled trial topical skin creams effective to treat superficial basal cell carcinoma engraftment of human ips cells and allogeneic porcine cells into pigs with inactivated rag and accompanying severe combined immunodeficiency human stem cells successfully transplanted grown in pigs bet bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure cancer cardiac connection illuminates promising new drug for heart failure unique pathological tau conformers from alzheimer s brains transmit tau pathology in nontransgenic mice more human like model of alzheimer s better mirrors tangles in the brain the relationship between disease activity sleep psychiatric distress and pain sensitivity in rheumatoid arthritis a cross sectional study pain thresholds linked to inflammation and sleep problems in arthritis patients genetic risk adherence to a healthy lifestyle and coronary disease following a healthy lifestyle can greatly reduce genetic heart attack risk the rapid escalation of fentanyl in illicit drug evidence in allegheny county pennsylvania analyzing street drugs points to potential early warning system in opioid crisis a longitudinal cohort study of body mass index and childhood exposure to secondhand tobacco smoke and air pollution the southern california children s health study tobacco smoke roadway air pollution linked to childhood obesity de novo assembly of a mb eukaryotic genome from short sequence reads sordaria macrospora a model organism for fungal morphogenesis discoveries in the fungal kingdom researchers decode genome with new technique using hiv networks to inform real time prevention interventions hiv transmission networks mapped to reduce infection rate shea neonatal intensive care unit nicu white paper series practical approaches to clostridioides difficile prevention guidance for preventing c. difficile in neonatal intensive care isolated limb perfusion with melphalan tumour necrosis factor alpha and oncolytic vaccinia virus improves tumour targeting and prolongs survival in a rat model of advanced extremity sarcoma viral therapy could boost limb saving cancer treatment interaction between autism linked mdgas and neuroligins suppresses inhibitory synapse development potential therapeutic target to treat autism schizophrenia and epilepsy air pollution aerosol interactions produce more bioavailable iron for ocean ecosystems iron dissolved by air pollution may increase ocean potential to trap carbon strad deficiency results in aberrant mtorc signaling during corticogenesis in humans and mice rare disease in amish children sheds light on common neurological disorders cytoskeleton dynamics control the first asymmetric cell division in arabidopsis zygote live cell imaging of asymmetric cell division in fertilized plant cells proportion and cost of unplanned day readmissions after sepsis compared with other medical conditions sepsis trumps cms s four medical conditions tracked for readmission rates nanoshell mediated photothermal therapy improves survival in a murine glioma model early tests find nanoshell therapy effective against brain cancer vitamin d mushrooms comparison of the composition of button mushrooms agaricus bisporus treated postharvest with uvb light or sunlight a scientific go for commercial production of vitamin d enhanced mushrooms hif alpha synergizes with glucocorticoids to promote bfu e progenitor self renewal emerging drug class may enhance red blood cell production in anemic patients diverting juvenile justice involved youth with behavioral health issues from detention preliminary findings from ohio s behavioral health juvenile justice bhjj initiative ohio s diversion program helps juvenile offenders with behavioral health issues monitoring of ebola virus makona evolution through establishment of advanced genomic capability in liberia genomics laboratory capability in liberia supports ebola virus outbreak response oral anticoagulant prescription in patients with atrial fibrillation and a low risk of thromboembolism insights from the ncdr pinnacle registry some atrial fibrillation patients receive unnecessary blood thinners quantifying economic resilience from input output susceptibility to improve predictions of economic growth and recovery new theory derived from classical physics predicts how economies respond to major disturbances adhesion failure at frames per second direct observation of the detachment process of a mushroom shaped adhesive adhesion at frames per second widespread natural adhesion system unraveled racial ethnic differences in mental health service use among adolescents with major depression racial and ethnic minority adolescents less likely to receive treatment for major depression study finds risperidone added to parent training and stimulant medication effects on attention deficit hyperactivity disorder oppositional defiant disorder conduct disorder and peer aggression drug therapies parent training help children with adhd severe aggression proteolytic processing of osteopontin by phex and accumulation of osteopontin fragments in hyp mouse bone the murine model of x linked hypophosphatemia gains made towards treatment of rare bone disease using dual frequency sonar to detect juvenile goliath grouper epinephelus itajarain mangrove habitat finding baby critically endangered goliath grouper fish hiding in mangroves with help of high tech sonogram g fast earthquake early warning potential for great earthquakes in chile satellite based earthquake early warning system tested against chilean great quakes global impacts of energy demand on the freshwater resources of nations global energy demand has adverse effects on freshwater resources of less developed nations gastrointestinal colonization with a cephalosporinase producing bacteroides species preserves colonization resistance against vancomycin resistant enterococcus and clostridium difficile in cephalosporin treated mice good bacteria armed with antibiotic resistance protect gut microbiome antiretroviral treatment of adult hiv infection recommendations of the international aids society usa panel international panel updates treatment guidelines for hiv infection protein interaction mapping identifies rbbp as a negative regulator of ebola virus replication another piece of ebola virus puzzle host and virus protein interaction amateur photographs reveal population history of a colonial seabird old tourist photos show seabird s rise over the last century predicting surgery targets in temporal lobe epilepsy through structural connectome based simulations computer model could hold key to personalized epilepsy treatment are baby boomers healthier than generation x ? a profile of australia s working generations using national health survey data gen x obesity a major problem for healthcare workforce australian study transcatheter aortic valve replacement with a balloon expandable valve in low risk patients in study tavr is superior to surgery for low risk patients with aortic valve stenosis role of dietary fats in modulating cardiometabolic risk during moderate weight gain a randomized double blind overfeeding trial lipogain study weight gain study suggests polyunsaturated oil healthier option calathea galdamesiana marantaceae a new endemic panamanian species botanist discovers new ground flowering plant in panama plasma cytokine concentrations indicate thatin vivohormonal regulation of immunity is altered during long duration spaceflight immune system is dazed and confused during spaceflight study reveals tai chi arterial compliance and muscle strength in older adults older subjects who regularly practise tai chi found to have better arterial compliance and greater muscle strength polarization vision seldom increases the sighting distance of silvery fish in the ocean clever camouflage beats super sight patterns of sequence divergence and evolution of the s orthologous regions between asian and african cultivated rice species increasing rice production using genes from the african species age dependent niche signals from the choroid plexus regulate adult neural stem cells cerebrospinal fluid signals control the behavior of stem cells in the brain response to ocean acidification in larvae of a large tropical marine fish rachycentron canadum putting larval cobia to the acid test potential resistance to increasingly acidic oceans by certain species of fish short lived pause in central california subsidence after heavy winter precipitation of drought groundwater loss sinks california land at alarming rate domestic impact of tuberculosis screening among new immigrants to ontario canada universal tb screening of immigrants to canada costly inefficient endothelial specific foxo depletion prevents obesity related disorders by increasing vascular metabolism and growth blood vessel growth key to healthy fat tissue research shows international ers ats guidelines on definition evaluation and treatment of severe asthma new guidelines for severe asthma provide updated treatment definition of disease the fair process effect in the classroom reducing the influence of grades on student evaluations of teachers fair classroom practices disarm threat of evaluation retaliation changes of the prevailing trade winds over the islands of hawaii and the north pacific documented decrease in frequency of hawaii s northeast trade winds search for deviations from the inverse square law of gravity at nm range using a pulsed neutron beam understanding gravity the nanoscale search for extra dimensions coastal evacuations by fish during extreme weather events impact of extreme weather events on striped bass influence of shrub encroachment on the soil microbial community composition of remnant hill prairies soil microbes shift as shrubs invade remnant hill prairies short term use of oral corticosteroids and related harms among adults in the united states population based cohort study common drugs uncommon risks ? higher rate of serious problems after short term steroid use the effects of in utero bisphenol a exposure on reproductive capacity in several generations of mice low dose bpa exposure affects fertility in next three generations of mice biomass changes and trophic amplification of plankton in a warmer ocean phytoplankton and zooplankton biomass are expected to decrease by and respectively by the end of century due to climate change self defending anti vandalism surfaces based on mechanically triggered mixing of reactants in polymer foils the atm strikes back researchers protect money with method borrowed from an aggressive beetle prosthesis with neuromorphic multilayered e dermis perceives touch and pain new e dermis brings sense of touch pain to prosthetic hands more than one third of systematic reviews did not fully report the adverse events outcome side effects not fully reported in more than percent of healthcare reviews sex differences in college student adherence to niaaa drinking guidelines college women exceed niaaa drinking guidelines more frequently than college men differentiation of human pluripotent stem cells to cells similar to cord blood endothelial colony forming cells new cells meant to form blood vessels developed treat peripheral artery disease the impact of climate change on mental health but will mental health be discussed at copenhagen ? major impacts of climate change expected on mental health past and ongoing shifts in joshua tree distribution support future modeled range contraction uncertain future for joshua trees in us southwest projected with climate change one health approach to cost effective rabies control in india study finds vaccination is the most cost effective way to reduce rabies deaths in india effects of population dispersal on regional signaling networks an example from northern iroquoia ancient pottery reveals insights on iroquoian population s power in th century pde inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model erectile dysfunction drugs allowed more chemotherapy to reach brain tumors in laboratory study subacute intranasal administration of tissue plasminogen activator promotes neuroplasticity and improves functional recovery following traumatic brain injury in rats stroke fighting drug offers potential treatment for traumatic brain injury only natural local odours allow homeward orientation in homing pigeons released at unfamiliar sites homing pigeons use local natural odors to find their way geography should not be destiny focusing hiv aids implementation research and programs on microepidemics in us neighborhoods hiv battle must focus on hard hit streets paper argues assessment of the validity of nuclear localized androgen receptor splice variant in circulating tumor cells as a predictive biomarker for castration resistant prostate cancer blood test can predict optimal treatment for advanced prostate cancer study finds emotion and underlying concerns during couples conflict an investigation of within person change how partners perceive each other s emotion during a fight has a huge impact on their reactions discriminating between natural versus induced seismicity from long term deformation history of intraplate faults north texas earthquakes occurring on dead faults seismology research shows learnings about the complexity of extracellular tau aid development of a blood based screen for alzheimer s disease blood test for tau alzheimer s disease under development methionine coordinates a hierarchically organized anabolic program enabling proliferation essential amino acid in humans methionine controls cell growth g protein coupled receptor g protein subunit signaling mediates renal dysfunction and fibrosis in heart failure researchers discover new therapeutic approach for cardiorenal syndrome type biomarkers on patient t cells diagnose active tuberculosis and monitor treatment response blood based biomarkers could enable simple accurate tb tests for diagnosis and monitoring clinical targeted exome based sequencing in combination with genome wide copy number profiling precision medicine analysis of pediatric brain tumors precision medicine advances pediatric brain tumor diagnosis and treatment proteomics reveals novel drosophila seminal fluid proteins transferred at mating fertility newly discovered proteins in seminal fluid transferred during mating may affect odds of producing offspring aav mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic k ras induced lung cancer gene therapy vectors carrying the telomerase gene do not increase the risk of cancer sub nanomolar detection of prostate specific membrane antigen in synthetic urine by synergistic dual ligand phage inexpensive accurate way to detect prostate cancer at home urine tests assessing the cost effectiveness of hepatitis c screening strategies in france cost effective universal screening for hepatitis c in france liberal alcohol legislation does it amplify the effects among swiss men of person related risk factors on heavy alcohol use ? alcohol laws have a preventive effect on young men fabrication of carbon nanotube thin films on flexible substrates by spray deposition and transfer printing with carbon nanotubes a path to flexible low cost sensors potential applications range from air quality monitors to electronic skin primate specific mir family members inhibit key genes in human trophoblast differentiation and are upregulated in preeclampsia study links small rna molecule to pregnancy complication comparative principles of dna methylation reprogramming during human and mouse in vitro primordial germ cell specification insights into the development of sperm and egg cell precursors in the embryo transgenerational phenotypic plasticity links breeding phenology with offspring life history female frogs modify offspring development depending on reproduction date stem cell released oncolytic herpes simplex virus has therapeutic efficacy in brain metastatic melanomas stem cell based therapy for targeting skin to brain cancer the transcription factor mafk induces emt and malignant progression of triple negative breast cancer cells through its target gpnmb novel molecular pathway in aggressive breast cancer offers potential therapeutic targets atypical functional connectivity of amygdala related to reduced symptom severity in children with autism unique patterns of neural communications found in brains of children with autism nutrient enrichment can increase the susceptibility of reef corals to bleaching improving water quality can help save coral reefs diffusion free grotthuss topochemistry for high rate and long life proton batteries proton transport highway may pave way to better high power batteries methylation subtypes and large scale epigenetic alterations in gastric cancer epigenetic analysis of stomach cancer finds new disease subtypes automated analysis of vital signs to identify patients with substantial bleeding before hospital arrival computerized vital signs analysis may help prevent trauma patients from bleeding to death clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin resistant staphylococcus aureus infections in adults and children guidelines for treatment of mrsa infections to help physicians manage common antibiotic resistant superbug feeding capitals urban food security and self provisioning in canberra copenhagen and tokyo scientists map food security self provision of major cities spinal cord injury enables aromatic l amino acid decarboxylase cells to synthesize monoamines new research offers help for spinal cord patients childhood obesity and dental caries in homeless children link between obesity and dental health in homeless children strengthened competition for the fish fish extraction from the baltic sea by humans aquatic mammals and birds seals birds and humans compete for fish in the baltic sea evidence that the great pacific garbage patch is rapidly accumulating plastic great pacific garbage patch growing rapidly study shows quiescence modulates stem cell maintenance and regenerative capacity in the aging brain scientists rejuvenate stem cells in the aging brain of mice erectile dysfunction and coronary artery disease prediction evidence based guidance and consensus experts call for urgent action to tackle strong links between impotence and heart disease protein mri contrast agent with unprecedented metal selectivity and sensitivity for liver cancer imaging research paves way for early detection of liver cancer selective detection of volatile organic compounds in microfluidic gas detectors based on like dissolves like gas sensing artificial nose created on d printers detection and phasing of single base de novo mutations in biopsies from human in vitro fertilized embryos by advanced whole genome sequencing mutation detection in human in vitro fertilized embryos using whole genome sequencing dying comfortably in very old age with or without dementia in different care settings a representative older old population study factors linked to dying comfortably for the very old gravity field of the orientale basin from the gravity recovery and interior laboratory mission insights into giant impacts on moon earth and mars a cat among the dogs leopard panthera pardus diet in a human dominated landscape in western maharashtra india cat bites dog in india s human dominated landscapes top prey for leopards is dogs memory th cells are protective in invasive staphylococcus aureus infection immunologists unearth key piece of mrsa vaccine puzzle design feature opinion cause analysis a method for extracting design intelligence from web reviews crowd review using the wisdom of the crowd to improve design cognitive functioning and driving simulator performance in middle aged and older adults with hiv disease age related effects of hiv may impact driving abilities of middle aged and older adults mitogenomes illuminate the origin and migration patterns of the indigenous people of the canary islands north africans were among the first to colonize the canary islands efficacy of epicutaneous immunotherapy in children with milk induced eosinophilic esophagitis skin patch shows promise for children with milk induced eosinophilic esophagitis warning signals confer advantage to prey in competition with predators bumblebees steal nests from insectivorous birds bees tell birds to buzz off how bumblebees steal birds nests functional identity of hypothalamic melanocortin neurons depends on tbx identity crisis of satiety neurons leads to obesity prevention and regressive effect of weight loss and risk factor modification on atrial fibrillation the reverse af study atrial fibrillation weight loss reverses heart condition in obesity sufferers rapid evolution of h n highly pathogenic viruses that emerged in china in new bird flu viruses in ducks after vaccines largely prevented h n in chickens patients perceptions of gene expression profiling in breast cancer treatment decisions breast cancer patients place huge emphasis on gene expression profiling test live birth after autograft of ovarian tissue cryopreserved during childhood first live birth after transplantation of ovarian tissue removed and frozen during childhood intestinal microbiota metabolism of l carnitine a nutrient in red meat promotes atherosclerosis new link between heart disease and red meat new understanding of cardiovascular health benefits of vegan vegetarian diets pathology and epidemiology of ceruminous gland tumors among endangered santa catalina island foxes urocyon littoralis catalinae in the channel islands usa endangered foxes on catalina island get promising treatment to reduce ear tumors hypofractionated radiation therapy for basal and squamous cell skin cancer a meta analysis short course radiation treatment is safe and effective for skin cancer global developmental gene programing involves a nuclear form of fibroblast growth factor receptor fgfr master orchestrator of the genome is discovered stem cell scientists report sex chromosome pre reduction in male meiosis of lethocerus patruelis st l heteroptera belostomatidae with some notes on the distribution of the species hide ambush kill eat the giant water bug lethocerus patruelis kills a fish air pollution exposure during pregnancy and symptoms of attention deficit and hyperactivity disorder in children in europe exposure to air pollution in pregnancy does not increase symptoms of attention deficit liver x receptor regulates the development of the dentate gyrus and autistic like behavior in the mouse researchers link defects in a nuclear receptor in the brain to autism spectrum disorders effect of varying doses of a monovalent h n influenza vaccine with and without as and mf adjuvants on immune response adjuvants improve immune response to h n flu vaccine a robust null hypothesis for the potential causes of megadrought in western north america climate scientists study the odds of a u.s. megadrought evidence of oxidative stress in the pathogenesis of fuchs endothelial corneal dystrophy free radicals in cornea may contribute to fuchs dystrophy most common cause of corneal transplants long term paired associative stimulation can restore voluntary control over paralyzed muscles in incomplete chronic spinal cord injury patients repeated stimulation treatment can restore movement to paralyzed muscles two new ppx mutations associated with resistance to ppo inhibiting herbicides in amaranthus palmeri two new mechanisms for herbicide resistance found in palmer amaranth an investigation into the safety of oral intake during labor ice chips only ? study questions restrictions on oral intake for women in labor activity profiles and hook tool use of new caledonian crows recorded by bird borne video cameras crows caught on camera fashioning special hook tools plasma oxytocin concentrations and oxtr polymorphisms predict social impairments in children with and without autism spectrum disorder blood oxytocin levels in normal range in children with autism study finds broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis genomic differences identified in common skin diseases may lead to better treatments addressing intimate partner violence and sexual violence among adolescents emerging evidence of effectiveness interrupting cycle of violence before young perpetrators victims reach adulthood development and validation of a protein based risk score for cardiovascular outcomes among patients with stable coronary heart disease protein based risk score may help predict cardiovascular events among patients with heart disease evidence of reducing ethanol content in beverages to reduce harmful use of alcohol reducing the harms of alcohol through weaker beer earliest direct evidence of plant processing in prehistoric saharan pottery earliest evidence discovered of plants cooked in ancient pottery it s about time earlier rewards increase intrinsic motivation. it s about time immediate rewards boost workplace motivation the influence of parental health literacy status on reach attendance retention and outcomes in a family based childhood obesity treatment program virginia simplifying information aids fight against childhood obesity study finds the brazil simsmoke policy simulation model the effect of strong tobacco control policies on smoking prevalence and smoking attributable deaths in a middle income nation anti tobacco policies responsible for brazil s big success in reducing smoking rates congo red dot paper test for antenatal triage and rapid identification of preeclampsia simple urine test allows for rapid diagnosis of preeclampsia climate index response profiling indicates larval transport is driving population fluctuations in nudibranch gastropods from the northeast pacific ocean scientists investigate link between skyrocketing sea slug populations warming seas association of cataract surgery with mortality in older women cataract surgery in older women associated with decreased risk of death potential consequences of not using live attenuated influenza vaccine recommendation against inhaled flu vaccine is good for now from intense rejection to advocacy how muslim clerics were engaged in a polio eradication initiative in northern nigeria a campaign involving muslim clerics has increased uptake of polio vaccination in nigeria sequencing and automated whole genome optical mapping of the genome of a domestic goat capra hircus first goat genome sets a good example for facilitating de novo assembly of large genomes growing minds evaluating the relationship between gardening and fruit and vegetable consumption in older adults gardening linked to increased vegetable consumption in older adults itraconazole targets cell cycle heterogeneity in colorectal cancer antifungal drug eliminates sleeping bowel cancer cells in mice hematuria as a marker of occult urinary tract cancer advice for high value care from the american college of physicians physician group issues advice raises questions about best practices for evaluating blood in the urine as a sign of cancer facial affect recognition linked to damage in specific white matter tracts in traumatic brain injury emotional processing deficits linked with white matter damage exposure to parental smoking in childhood is associated with increased risk of carotid atherosclerotic plaque in adulthood the cardiovascular risk in young finns study smoking in front of your kids may increase their risk of heart disease as adults common variants at p and q are associated with increased susceptibility to optic nerve degeneration in glaucoma study links genes to common forms of glaucoma baleen whales host a unique gut microbiome with similarities to both carnivores and herbivores a whale of a tale whale microbiome shares characteristics with both ruminants predators structural genomic changes underlie alternative reproductive strategies in the ruff philomachus pugnax supergene underlies genetic differences sexual behavior in male ruff human glia can both induce and rescue aspects of disease phenotype in huntington disease swapping sick for healthy brain cells slows huntington s disease masticatory muscles of mouse do not undergo atrophy in space cheek muscles hold up better than leg muscles in space low level of education is associated with later stage at diagnosis and reduced survival in cutaneous malignant melanoma a nationwide population based study in sweden lower education linked to premature death from malignant melanoma self assembling elastin like peptides growth factor chimeric nanoparticles for the treatment of chronic wounds growth factor containing nanoparticles accelerate healing of chronic wounds potential for spin based information processing in a thin film molecular semiconductor new material for quantum computing discovered out of the blue effect of moderate diet induced weight loss and weight regain on cardiovascular structure and function moderate weight loss in obese people improves heart function the sirt deacetylase stabilizes slug to control malignancy of basal like breast cancer silencing sirt a sirtuin enzyme reduces malignancy in deadly breast cancer subtype trial of cannabidiol for drug resistant seizures in the dravet syndrome cannabidiol reduces seizures in children with severe epilepsy measuring the volume outcome relation for complex hospital surgery medical literature may overemphasize role of hospital volume in patient outcomes gwtc a gravitational wave transient catalog of compact binary mergers observed by ligo and virgo during the first and second observing runs ligo and virgo announce four new gravitational wave detections visceral leishmaniasis in an environmentally protected area in southeastern brazil epidemiological and laboratory cross sectional investigation of phlebotomine fauna wild hosts and canine cases tracking leishmaniasis in dogs wild animals and sand flies in brazil hidden diversity of african yellow house bats vespertilionidae scotophilus insights from multilocus phylogenetics and lineage delimitation fuzzy yellow bats reveal evolutionary relationships in kenya aggressive antisocial boys develop into physically strong young men aggressive boys tend to develop into physically stronger teens obesity impairs academic attainment in adolescence findings from alspac a uk cohort obesity associated with lower academic attainment in teenage girls says new study efficacy of cardio respiratory aerobic exercise in rheumatoid arthritis meta analysis of randomized controlled trials aerobic exercise safe and effective for rheumatoid arthritis patients experts say a portable paper based microfluidic platform for multiplexed electrochemical detection of human immunodeficiency virus and hepatitis c virus antibodies in serum on the go diagnosis of hiv and hcv co infections can joy buy you money ? the impact of the strength duration and phases of an entrepreneur s peak displayed joy on funding performance finding the goldilocks level of enthusiasm for business pitches systematic review efficacy and safety of medical marijuana in selected neurologic disorders report of the guideline development subcommittee of the american academy of neurology medical marijuana in treatment of certain brain diseases experts weigh in the treatment of ictal asystole with cardiac pacing researchers find cardiac pacing helps epilepsy patients with ictal asystole persistent mucosal damage and risk of fracture in celiac disease chronic intestinal damage raises hip fracture rate in celiac disease patients stromal hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth active hedgehog signalling in connective tissue cells protects against colon cancer concerns about cancer risk and experiences with genetic testing in a diverse population of patients with breast cancer a third of breast cancer patients concerned about genetic risk tgf signaling regulates temporal neurogenesis and potency of neural stem cells in the cns molecular time signalling controls stem cells during brain s development fracture risk after gastric bypass surgery a retrospective cohort study thirty percent increase in risk of fracture after gastric bypass monodispersed calcium carbonate nanoparticles modulate local ph and inhibit tumor growth in vivo novel nanoparticle made of common mineral may help keep tumor growth at bay pilot study of impact of a pedal desk on postprandial responses in sedentary workers pilot study suggests pedal desks could address health risks of sedentary workplace horizontal gene transfer from diverse bacteria to an insect genome enables a tripartite nested mealybug symbiosis study of insect bacteria reveals genetic secrets of symbiosis smartphone hearing screening with integrated quality control and data management new smartphone app offers easy and inexpensive solution for hearing screening discussion of potentially sensitive topics with young people less than half of u.s. youth discuss sensitive topics with their doctors a new macrofaunal limit in the deep biosphere revealed by extreme burrow depths in ancient sediments new depth limit for deep sea marine burrows nonlinear emission of molecular ensembles strongly coupled to plasmonic lattices with structural imperfections new type of low energy nanolaser that shines in all directions core size dependent hole transfer from a photoexcited cdse zns quantum dot to a conductive polymer small size enhances charge transfer in quantum dots angiotensin receptor agonistic autoantibodies induce pre eclampsia in pregnant mice new research on pre eclampsia in mice may have important implications for humans age related dna methylation in normal breast tissue and its relationship with invasive breast tumor methylation epigenetic alterations may contribute to age related breast cancer risk reversal of learning deficits in a tsc mouse model of tuberous sclerosis drug reverses mental retardation caused by genetic disorder hope for correcting how autism disrupts brain simulation of deepwater horizon oil plume reveals substrate specialization within a complex community of hydrocarbon degraders microbe mystery solved what happened to the deepwater horizon oil plume ? outcomes of endovascular abdominal aortic aneurysm repair in high risk patients even high risk patients can benefit from aortic aneurysm repair study finds effects of fine particles on children s hospital admissions for respiratory health in seville spain contaminant particles increase hospital admissions for children with respiratory illnesses can big data shed light on the origins of pediatric cancer ? evidence of link between cancer light therapy inconclusive but warrants consideration an orthogonal proteomic survey uncovers novel zika virus host factors zika virus study reveals possible causes of brain pathology individual variation in whole animal hypoxia tolerance is associated with cardiac hypoxia tolerance in a marine teleost heart is fishy defense against ocean s dead zones evidence for atmospheric cold trap processes in the noninverted emission spectrum of kepler ab using hst wfc astronomers discover sunscreen snow falling on hot exoplanet cadmium and lead in chocolates commercialized in brazil lead and cadmium found in some chocolate bought in brazil natural product biosynthetic gene diversity in geographically distinct soil microbiomes genes culled from desert soils suggest potential medical resource genomic analysis phenotype and virulence of the historical brazilian smallpox vaccine strain ioc implications for the origins and evolutionary relationships of vaccinia virus new clues on the history of the smallpox vaccine virus a randomized double blind placebo controlled phase ii study of oral elnd scyllo inositol in young adults with down syndrome without dementia clinical trial investigates alzheimer s disease drug in people with down syndrome postmenopausal women with greater paracardial fat have more coronary artery calcification than premenopausal women the study of women s health across the nation swan cardiovascular fat ancillary study certain heart fat associated with higher risk of heart disease in postmenopausal women ebpa vaccine antibodies block binding of enterococcus faecalis to fibrinogen to prevent catheter associated bladder infection in mice in mice vaccine stops urinary tract infections linked to catheters translational analysis of effects of prenatal cocaine exposure on human infant cries and rat pup ultrasonic vocalizations baby cries show evidence of cocaine exposure during pregnancy road trauma in teenage male youth with childhood disruptive behavior disorders a population based analysis disruptive behaviour disorders in male teenagers associated with increased risk of road crashes breast density and benign breast disease risk assessment to identify women at high risk of breast cancer tool boosts accuracy in assessing breast cancer risk high fitness costs of climate change induced camouflage mismatch evolutionary clock ticks for snowshoe hares facing climate change gender differences in first and secondhand smoke exposure spirometric lung function and cardiometabolic health in the old order amish a novel population without female smoking secondhand smoke ups heart disease in unique group of female nonsmokers amish women cotinine in children admitted for asthma and readmission secondhand smoke exposure increases odds of hospital asthma readmission for children impaired gaba and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice potential cause of severe sleep disorder discovered implications for parkinson s disease maternal prenatal weight gain and autism spectrum disorders new study examines link between pregnancy weight gain autism spectrum disorders steroid hormone signaling is essential for pheromone production and oenocyte survival genetic roots of insect s waterproof coating could lead to innovative pest control influence of tree species on continental differences in boreal fires and climate feedbacks tree species influence boreal forest fire behavior subsequent effects on climate step up asthma care in children uncontrolled on inhaled corticosteroids stepping up asthma treatment in children leads to improvement prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes new understanding of role of telomeres in tumor growth delamanid improves outcomes and reduces mortality for multidrug resistant tuberculosis tb drug could reduce mortality for multidrug resistant mdr tb and extremely drug resistant xdr tb cases gel forming mucins form distinct morphologic structures in airways cystic fibrosis alters the structure of mucus in airways ocean acidification compromises recruitment success of the threatened caribbean coral acropora palmata new ocean acidification study shows added danger to already struggling coral reefs involvement of innate immune system in late stages of inherited photoreceptor degeneration commonalities in late stages of inherited blinding diseases suggest targets for therapy investigation of information flow during a novel working memory task in individuals with traumatic brain injury brain connectivity changes with working memory after tbi immunization with a heat killed preparation of the environmental bacteriummycobacterium vaccaepromotes stress resilience in mice immunization with bacteria promotes stress resilience coping behaviors in mice crustal rheology controls on the tibetan plateau formation during india asia convergence strength of tectonic plates may explain shape of the tibetan plateau crisis or self correction rethinking media narratives about the well being of science crisis or self correction rethinking how the media cover science imaging mass spectrometry reveals crosstalk between the fallopian tube and the ovary that drives primary metastasis of ovarian cancer crosstalk between fallopian tube ovary may drive the spread of ovarian cancer effects of a high vs moderate volume of aerobic exercise on adiposity outcomes in postmenopausal women exercising minutes per week better for reducing total fat in postmenopausal women mapping evaporative water loss in desert passerines reveals an expanding threat of lethal dehydration us desert songbirds at risk in a warming climate a new target for alzheimer s disease a small molecule serca activator is neuroprotective in vitro and improves memory and cognition in app ps mice molecule could improve memory reduce alzheimer s degradation study finds traf fi c light labels and choice architecture promoting healthy food choices traffic light food labels positioning of healthy items produce lasting choice changes clinical and safety outcomes associated with treatment of acute venous thromboembolism patient s question triggers important study about blood thinners follow up of patients with clear cell adenocarcinoma of the vagina and cervix the des saga death risk high for young women exposed in utero mirnas trigger widespread epigenetically activated sirnas from transposons in arabidopsis small rna pathway defends genome against enemy within meganuclease targeting of pcsk in macaque liver leads to stable reduction in serum cholesterol genome editing reduces cholesterol in large animal model laying human trial groundwork therapeutic reduction of ataxin extends lifespan and reduces pathology in tdp mice suppressing single protein greatly extends life span of mice with form of als study shows disruption of the sapm locus in mycobacterium bovis bcg improves its protective efficacy as a vaccine against m. tuberculosis efficacy of tuberculosis vaccine enhanced thanks to new research intimate partner abuse factors associated with women s health a general population study intimate abuse study finds clear links with poor health and calls for holistic primary care approach could machine learning break the convection parameterization deadlock ? machine learning may be a game changer for climate prediction grey matter volume differences associated with extremely low levels of cannabis use in adolescence teen brain volume changes with small amount of cannabis use study finds elucidating pretreatment cognitive impairment in breast cancer patients the impact of cancer related post traumatic stress cancer and chemobrain cancer diagnosis affects cognitive function association of varying number of doses of quadrivalent human papillomavirus vaccine with incidence of condyloma three doses of hpv vaccine recommended against genital warts an analysis of water collection labor among women and children in sub saharan african countries million women children tasked with household water collection in african countries whole proteome clustering of proteobacterial genomes reveals conserved proteins and significant annotation issues amid genomic data explosion scientists find proliferating errors towards a transparent flexible scalable and disposable image sensor using thin film luminescent concentrators new imaging device is flexible flat and transparent tardigrades use intrinsically disordered proteins to survive desiccation tardigrades use unique protein to protect themselves from desiccation anthropogenic signatures of lead in the northeast atlantic anthropogenic lead still present in european shelf seas reducing intrinsic energy dissipation in diamond on diamond mechanical resonators toward one million quality factor development of mems sensor chip equipped with ultra high quality diamond cantilevers when the going gets tough the why of goal striving matters finding murray s magic ability to manage goals makes an athlete successful writing about past failures attenuates cortisol responses and sustained attention deficits following psychosocial stress analyzing past failures may boost future performance by reducing stress association between soluble klotho and change in kidney function the health aging and body composition study low levels of circulating protein linked to kidney function decline clinical management of potential toxicities and drug interactions related to cyclin dependent kinase inhibitors in breast cancer practical considerations and recommendations side effects not a major problem for new class of breast cancer drugs active propagation of dendritic electrical signals in c. elegans how brain cells in microscopic worm send electrical signals impact of the california breast density law on primary care physicians california breast density law slow to have an impact initiation of warfarin in patients with atrial fibrillation early effects on ischaemic strokes warfarin increases risk of stroke among atrial fibrillation patients in first days of use glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase to combat deadly brain cancer target the stem cells sleepmore in seattle later school start times are associated with more sleep and better performance in high school students teens get more sleep with later school start time researchers find genome wide mapping of the dna methylation in the human malaria parasite chemical modification discovered in human malaria parasite dna the proliferative activity of mammary epithelial cells in normal tissue predicts breast cancer risk in premenopausal women new predictive tool for assessing breast cancer risk high resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting engineered bacteria effectively target tumors enabling tumor imaging potential in mice harmful algal blooms and climate change learning from the past and present to forecast the future harmful algal blooms and climate change preparing to forecast the future the influence of obesity on the outcome of treatment of lumbar disc herniationanalysis of the spine patient outcomes research trial sport study finds poorer outcomes for obese patients treated for lumbar disc herniation dietary fiber and colorectal cancer risk a nested case control study using food diaries association of fiber and colorectal cancer risk differs depending on dietary assessment method human memory t cells with a naive phenotype accumulate with aging and respond to persistent viruses boosting immunity in older adults study unmasks new infection fighting t cells mortality quadrupled among opioid driven hospitalizations notably within lower income and disabled white populations four fold jump in deaths in opioid driven hospitalizations polymorphisms in the sialic acid binding immunoglobulin like lectin siglec gene are associated with susceptibility to asthma subtle mutations in immune gene may increase risk for asthma linking high energy cosmic particles by black hole jets embedded in large scale structures new for three types of extreme energy space particles theory shows unified origin universal distribution of component frequencies in biological and technological systems survival of the fittest now applies to computers surprising similarities found between genetic and computer codes the sudden emergence of pathogenicity in insect fungus symbioses threatens naive forest ecosystems spread of fungus farming beetles is bad news for trees fiber mediated nourishment of gut microbiota protects against diet induced obesity by restoring il mediated colonic health dietary fiber protects against obesity and metabolic syndrome study finds mortality in patients treated with extended duration dual antiplatelet therapy after drug eluting stent implantation a pairwise and bayesian network meta analysis of randomised trials meta analysis finds extended dual antiplatelet therapy associated with increased mortality after drug eluting stent implantation a role for schwann cell derived neuregulin in remyelination glial cells assist in the repair of injured nerves symptomatic hiv positive persons in rural mozambique who first consult a traditional healer have delays in hiv testing traditional healers contribute to hiv care delays study finds changes in lake erie benthos over the last years historical perspectives current status and main drivers zebra quagga mussels trump pollution as change agents in lake erie a single population of red globular clusters around the massive compact galaxy ngc astronomers find a galaxy unchanged since the early universe nicotine and toxicant exposure among u.s. smokeless tobacco users results from to national health and nutrition examination survey data higher nicotine carcinogen levels among smokeless tobacco users compared with cigarette users the growth pattern of neandertals reconstructed from a juvenile skeleton from el sidr n spain reconstructing how neanderthals grew based on an el sidr n child implications for climate sensitivity from the response to individual forcings examination of earth s recent history key to predicting global temperatures selkirk rex morphological and genetic characterization of a new cat breed new cat breed selkirk rex genetically different from other curly haired cats experience dependent plasticity drives individual differences in pheromone sensing neurons long term exposure to female scents changes courtship behavior in male mice prevalence of and risk factors for quinolone resistant neisseria gonorrhoeae infection in ontario antibiotic resistant gonorrhea increases from percent to percent in ontario il overexpression in mouse lungs triggers systemic genotoxicity in peripheral blood genetic damage caused by asthma shows up in circulating blood stream too regulation and disregulation of mammalian nucleotide excision repair a pathway to nongermline breast carcinogenesis dna repair is high in heart nonexistent in brain argininosuccinate synthetase loss in invasive bladder cancer regulates survival through general control nonderepressible kinase mediated eukaryotic initiation factor activity and is targetable by pegylated arginine deiminase arginine deprivation may be a useful strategy for treating bladder cancers new study finds full genome sequences of influenza a h n pdm viruses isolated from finnish patients from to novel therapeutic agent for tamiflu resistant ph n influenza virus discovered the thromboprotective effect of bortezomib is dependent on the transcription factor kruppel like factor klf cancer drug boosts levels of vascular protective gene klf amyloid beta dynamics correlate with neurological status in the injured human brain rapid changes in key alzheimer s protein described in humans childhood psychiatric disorders as risk factor for subsequent substance abuse a meta analysis childhood psychiatric disorders increase risk for later adult addiction development of a genomic dna reference material panel for rett syndrome mecp related disorders genetic testing rett syndrome genetic variants now available for advance testing diagnosis and research partial sleep restriction activates immune response related gene expression pathways experimental and epidemiological studies in humans new links between sleep deprivation immune system discovered deficiency of lipid phosphatase ship enables long term reconstitution of hematopoietic inductive bone marrow microenvironment findings may help overcome hurdle to successful bone marrow transplantation valproate and bone loss itraq proteomics show that valproate reduces collagens and osteonectin in sma cells solving the mystery of bone loss from drug for epilepsy and bipolar disorder immunologic escape after prolonged progression free survival with epidermal growth factor receptorvariant iii peptide vaccination in patients with newly diagnosed glioblastoma vaccine extends survival for patients with deadly brain cancers outcomes after proton therapy for treatment of pediatric high risk neuroblastoma proton therapy shows efficacy low toxicity in large cohort of children with high risk neuroblastoma posttranscriptional control of the stem cell and neurogenic programs by the nonsense mediated rna decay pathway protein switch dictates cellular fate stem cell or neuron long lasting crossmodal cortical reorganization triggered by brief postnatal visual deprivation brief postnatal blindness triggers long lasting reorganization in the brain testing the myth tolerant dogs and aggressive wolves myth of tolerant dogs and aggressive wolves refuted influenza infection triggers disease in a genetic model of experimental autoimmune encephalomyelitis one step closer in explaining ms relapse during upper respiratory infection holocene earthquakes of magnitude during westward escape of the olympic mountains washington large earthquakes along olympic mountain faults washington state usa eating disorders and trauma history in women with perinatal depression pregnancy related depression linked to eating disorders and abuse histories mesenchymal niche specific expression of cxcl controls quiescence of treatment resistant leukemia stem cells how sleeper cell cancer stem cells are maintained in chronic myelogenous leukemia oregon s coordinated care organizations and their effect on prenatal care utilization among medicaid enrollees coordinated care organizations lead to more timely prenatal care high prevalence of vitamin d deficiency in patients with basal cell nevus syndrome genetic predisposition to certain skin cancers may be associated with vitamin d deficiency widespread rna editing dysregulation in brains from autistic individuals autism changes in rna editing in the brain play an important role scientists find frequent truncating mutations of stag in bladder cancer in a surprise finding gene mutation found linked to low risk bladder cancer international legal barriers to canada s marijuana plans canada s plans to legalize marijuana contravene un s international conventions say experts efficacy of nitric oxide with or without continuing antihypertensive treatment for management of high blood pressure in acute stroke enos a partial factorial randomised controlled trial clinical trial could change standard treatment for stroke guns impulsive angry behavior and mental disorders results from the national comorbidity survey replication ncs r nearly one in ten u.s. adults have impulsive anger issues and access to guns creative destruction in wall street s technological arms race evidence from patent data stock market changes patents provide insight into wall street technology arms race dendritic cell targeting of bacillus anthracis protective antigen expressed by lactobacillus acidophilus protects mice from lethal challenge goodbye needle hello smoothie new generation oral vaccine uses dairy probiotics to protect against disease inertial microfluidics with integrated vortex generators using liquid metal droplets as fugitive ink mini centrifuge for simpler study of blood cells opens new organ on chip possibilities assessment of the lead ecg as a screening test for detection of cardiovascular disease in healthy general populations of young people years of age a scientific statement from the american heart association and the american college of cardiolog congenital genetic heart disease screening recommendations for people fatty acid binding protein fabp promotes lipolysis of lipid droplets de novo fatty acid fa synthesis and activation of nuclear factor kappa b nf b signaling in cancer cells novel role of protein in important pathways that lead to cancer malignancy quorum sensing down regulation counteracts the negative impact of pseudomonas aeruginosa on cftr channel expression function and rescue in human airway epithelial cells cystic fibrosis discovery of a key molecule for improving treatments a new species of aframomum zingiberaceae from d.r. congo spicy discovery of new ginger species spices up african wildlife surveys loss of migratory behaviour increases infection risk for a butterfly host canceled flights for monarch butterflies loss of migration means more disease self assembled nm cu micelles enhance accumulation in rat glioblastoma nanocarriers may carry new hope for brain cancer therapy prediction of residual angina after percutaneous coronary intervention heart attack patients without obstructive coronary artery disease at high risk of residual angina altered autonomic nervous system activity as a potential etiological factor of premenstrual syndrome and premenstrual dysphoric disorder bad pms may mean a depressed nervous system and fatty acid supplementation may reduce autism symptoms based on parent report in preterm toddlers trial of omega fatty acid supplementation in toddlers born preterm shows promising results scalable quantum circuit and control for a superconducting surface code innovative control system paves the way for large scale universal quantum computing social information processing patterns mediate the impact of preventive intervention on adolescent antisocial behavior research explores factors that impact adolescent mental health a new method for preparing mesenchymal stem cells and labeling with ferumoxytol for cell tracking by mri bio mimicry method developed for preparing labeling stem cells peptides with potential cardioprotective effects derived from dry cured ham byproducts dry cured ham bones a source of heart healthy peptides ? luteolin decreases igf ii production and downregulates insulin like growth factor i receptor signaling in ht human colon cancer cells plant flavonoid luteolin blocks cell signaling pathways in colon cancer cells identifying and characterizing hepatitis c virus hotspots in massachusetts a spatial epidemiological approach spatial epidemiology used to identify key hepatitis c hotspots in massachusetts the impact of climatic risk factors on the prevalence distribution and severity of acute and chronic trachoma climate may play a role in the distribution and prevalence of trachoma mapping of brain activity by automated volume analysis of immediate early genes new technique captures activity of an entire brain in a snapshot maternal immune activation during the third trimester is associated with neonatal functional connectivity of the salience network and fetal to toddler behavior. immune system activation in pregnant women can shape brain development in their babies simultaneous scalp skull kidney and pancreas transplant from a single donor first of its kind procedure combines scalp skull kidney and pancreas transplant free base nicotine determination in electronic cigarette liquids by h nmr spectroscopy free base form of nicotine in electronic cigarettes structural basis of oligomerisaton in the stalk region of dynamin like mxa a clamp for emerging flu viruses researchers unravel secret of innate immune response first results from the lyman alpha galaxies in the epoch of reionization lager survey cosmological reionization at z dawn of the cosmos seeing galaxies that appeared soon after the big bang evaluation of the relative effectiveness of three hiv testing strategies targeting african american men who have sex with men msm in new york city odds of detecting hiv varies by method new study finds transcriptional analyses provide new insight into the late stage immune response of a diseased caribbean coral shedding light on immune response in diseased corals abuse in childhood and risk of uterine leiomyoma the role of emotional support in biologic resilience child teen sexual and physical abuse linked to fibroids in premenopausal women risk of breast cancer recurrence associated with carbohydrate intake and tissue expression of igfi receptor limiting carbs could reduce breast cancer recurrence in women with positive igf receptor stage at diagnosis and colorectal cancer survival in six high income countries a population based study of patients diagnosed during differences in staging and treatment likely to be behind uk s low bowel cancer survival selective brafv e inhibition enhances t cell recognition of melanoma without affecting lymphocyte function combined braf targeted and immunotherapy shows promise for melanoma treatment future extreme sea level seesaws in the tropical pacific extreme pacific sea level events to double in future high resolution dynamical downscaling ensemble projections of future extreme temperature distributions for the united states high resolution climate models present alarming new projections for us concussion symptoms and return to play time in youth high school and college american football athletes concussion outcomes differ among football players from youth to college influence of in utero exposure to maternal depression and natural disaster related stress on infant temperament at months the children of superstorm sandy climate change poses greater risk of mental health challenges for children born to depressed mothers gpr controls cns angiogenesis and blood brain barrier integrity by promoting ligand specific canonical wnt signaling blood vessel growth in brain relies on a protein found in tumor blood vessels can consuming caffeine while breastfeeding harm your baby ? an interview with ruth lawrence phd can consuming caffeine while breastfeeding harm your baby ? new analysis reexamines the value of cancer care in the united states compared to western europe us spends more on cancer care saves fewer lives than western europe selection on the regulation of sympathetic nervous activity in humans and chimpanzees ramped up fight or flight response points to history of warfare for humans and chimps are attitudes toward labeling nano products linked to attitudes toward gmo ? exploring a potential spillover effect for attitudes toward controversial technologies public opinion on gmos might impact similar technologies in stores product structure based integrated life cycle analysis psila a technique for cost modelling and analysis of closed loop production systems closing the loop for greener production technique to analyze production processes highlights financial benefits of recycling early coverage access utilization and health effects associated with the affordable care act medicaid expansions medicaid expansion significantly boosts insurance coverage among low income adults early life influences on child weight outcomes in the study to explore early development rapid weight gain during infancy possible risk factor for later obesity in kids with autism bending the curve a community based behavioral parent training model to address adhd related concerns in the voluntary sector in denmark parent training on adhd using volunteers can help meet growing treatment needs heterosexual hiv transmission after initiation of antiretroviral therapy a prospective cohort analysis antiretroviral therapy associated with decreased risk of hiv transmission see how much we ve sold already ! effects of displaying sales and stock level information on consumers online product choices how displaying real time sales and stock levels online affects shoppers relationship between antiepileptic drugs and suicide attempts in patients with bipolar disorder antiepileptic drugs not linked to suicide among those with bipolar disorder reduction in late mortality among year survivors of childhood cancer long term survivors of childhood cancer living longer thanks in part to treatment changes the f mutation causes cftr misprocessing and cystic fibrosis like disease in pigs pig model of cystic fibrosis improves understanding of disease efficacy of an accelerated hepatitis b vaccination program during pregnancy stepped up vaccine series for hepatitis b is effective during pregnancy association of bacteria and viruses with wheezy episodes in young children prospective birth cohort study bacteria to blame in asthma attacks in children research suggests evaluation of potential breath biomarkers for active smoking assessment of smoking habits presence of chemical in smoker s breath indicates person has smoked in last three days pleiotropic age dependent effects of mitochondrial dysfunction on epidermal stem cells surprising results casts new light on the free radical theory of aging attachment style spirituality and depressive symptoms among individuals in substance abuse treatment lack of ultimate meaning in life associated with alcohol abuse drug addiction and other mental health problems belief in aids related conspiracy theories and mistrust in the government relationship with hiv testing among at risk older adults government mistrust deters older adults from hiv testing multicenter review of diaphragm pacing in spinal cord injury diaphragm pacing in spinal cord injury successful in weaning patients from ventilators human micrornas mir mir mir a and mir are associated with panic disorder and regulate several anxiety candidate genes and related pathways micro rna s contribute to risk for panic disorder strategies and opportunities to stop colon cancer in priority populations pragmatic pilot study design and outcomes mailing free tests to patients homes boosts colon cancer screening rates study shows are treponema pallidum specific rapid and point of care tests for syphilis accurate enough for screening in resource limited settings ? evidence from a meta analysis rapid point of care tests for syphilis the future of diagnosis climate change impacts on the biophysics and economics of world fisheries effects of climate change to further degrade fisheries resources epigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brain molecular tag explains differences in brain s response to anger fear relationship of neuropsychiatric symptoms with falls in alzheimer s disease does exercise modify the risk ? exercise may lessen fall risk for older adults with alzheimer s melatonin receptor type a gene linked to alzheimer s disease in old age a gene linked to job related exhaustion in shift workers increases the risk of alzheimer s changing access to ice land and water in arctic communities new perspective on changing travel conditions in arctic communities a long forgotten dinosaur bone from a museum cabinet uncovered to be a japan s iconic extinct mammal paleoparadoxia desmostylia mammalia a sleeping treasure in a university collection has turned out to be japan s iconic extinct mammal extrathymic aire expressing cells are a distinct bone marrow derived population that induce functional inactivation of cd t cells autoimmune disease strategy emerges from immune cell discovery capture of sprinkler irrigation water by container grown ornamental plants how container grown plants capture sprinkler irrigation water improved axillary evaluation following neoadjuvant therapy for patients with node positive breast cancer using selective evaluation of clipped nodes implementation of targeted axillary dissection targeted axillary dissection of lymph nodes after chemotherapy improves staging accuracy of node positive breast cancer benzodiazepine use among older adults with chronic obstructive pulmonary disease frequently prescribed drug used in concerning ways with harmful side effects the billion cost of ash dieback in britain ash dieback is predicted to cost billion in britain illuminating gillnets to save seabirds and the potential for multi taxa bycatch mitigation led lights reduce seabird death toll from fishing by percent colour change on different body regions provides thermal and signalling advantages in bearded dragon lizards bearded dragons change color on different body parts for social signals and temperature regulation fda regulation of indoor tanning devices and opportunities for skin cancer prevention state regulations for indoor tanning could lead to a national regulatory framework influenza vaccination requirements for healthcare personnel in u.s. hospitals results of a national survey less than half of us hospitals require flu shots for staff despite risk to patients cold urticaria immunodeficiency and autoimmunity related toplcg deletions cause of rare immune disease identified genetic mutation leads to cold allergy immune deficiency and autoimmunity plant made polio type stabilized vlps a candidate synthetic polio vaccine plant produced polio vaccines could help eradicate age old disease digestibility of dietary fiber in distillers coproducts fed to growing pigs swine researchers seek answers to fiber s low digestibility alterations in the vaginal microbiome by maternal stress are associated with metabolic reprogramming of the offspring gut and brain maternal stress alters offspring gut brain through vaginal microbiome genome wide meta analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia new genes for short sightedness new genes that cause refractive errors and myopia identified denosumab induces tumor reduction and bone formation in patients with giant cell tumor of bone denosumab reduces burden of giant cell tumor of the bone study suggests paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine link between backup immune defense mutation seen in crohn s disease discovered internal mammary and medial supraclavicular irradiation in breast cancer irradiation of regional nodes in stage i iii breast cancer patients affects overall survival endocrine disruption in human placenta expression of the dioxin inducible enzyme cyp a is correlated with that of thyroid hormone regulated genes endocrine disrupting chemicals alter thyroid hormone activity during pregnancy affect thyroid hormone activity tumor ensemble based modeling and visualization of emergent angiogenic heterogeneity in breast cancer image based computer model reveals finer details of tumor blood flow cross sectional associations of objectively measured physical activity and sedentary time with body composition and cardiorespiratory fitness in mid childhood the panic study exchanging sedentariness for low intensity physical activity can prevent weight gain in children most atolls will be uninhabitable by the mid st century because of sea level rise exacerbating wave driven flooding many low lying atoll islands could be uninhabitable by mid st century immunization with hiv gp subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal shiv challenges circulating blood antibodies are not required for hiv protection study suggests the queen bee a myth ? the effect of top level female leadership on subordinate females is the queen bee phenomenon a myth ? concentrations and migratabilities of hazardous elements in second hand children s plastic toys many second hand plastic toys could pose a risk to children s health study suggests bubr alterations that reinforce mitotic surveillance act against aneuploidy and cancer researchers investigate protein s role in cell division using alternatives to the car and risk of all cause cardiovascular and cancer mortality avoiding the car for travel could significantly lower risk of illness and death prevalence and associations of hydroxyvitamin d deficiency in children and adolescents in the united states results from nhanes millions of u.s. children low in vitamin d antipsychotic use with and without comorbid psychiatric diagnosis among adults with intellectual and developmental disabilities antipsychotics common for adults with intellectual and developmental disabilities randomized noninferiority trial of telephone versus in person genetic counseling for hereditary breast and ovarian cancer genetic counseling via telephone as effective as in person counseling cluster randomized crossover trial of head positioning in acute stroke study settles debate over head position following stroke planetary scale streak structure reproduced in high resolution simulations of the venus atmosphere with a low stability layer giant pattern discovered in the clouds of planet venus stereotyped high frequency oscillations discriminate seizure onset zones and critical functional cortex in focal epilepsy engineer locates brain s seizure onset zone in record time clustered patterns of species origins of nature derived drugs and clues for future bioprospecting families of drugs developed from bacteria fungi snails leeches and other such species association between general and central adiposity in childhood and change in these with cardiovascular risk factors in adolescence prospective cohort study high bmi in childhood linked to greater heart disease risk in adolescence effect of serum hydroxyvitamin d on risk for type diabetes may be partially mediated by subclinical inflammation results from the monica kora augsburg study vitamin d could lower risk of developing type diabetes study suggests vitamin b dependent taurine synthesis regulates growth and bone mass pathway between gut liver regulates bone mass biological process behind role of vitamin b in bone formation unravelled associations between intimate partner violence and health among men who have sex with men a systematic review and meta analysis intimate partner violence in men who have sex with men is linked to adverse health effects origins of two hemiclonal hybrids among threehexagrammosspecies teleostei hexagrammidae genetic diversification through host switching all female hybrid fish species uses males for better genetics overdose education and naloxone rescue kits for family members of opioid users characteristics motivations and naloxone use researchers provide insights for reducing drug overdoses through community education on the relative motions of long lived pacific mantle plumes another clue for fast motion of the hawaiian hotspot peripheral synucleinopathy in early parkinson s disease submandibular gland needle biopsy findings study determines saliva gland test can spot early parkinson s disease potential for larger earthquakes in the east san francisco bay area due to the direct connection between the hayward and calaveras faults california quake risk newly discovered link between calaveras hayward faults means potentially larger earthquakes differences in analgesic use in community dwelling persons with and without alzheimer s disease use of prescription pain medicines is significantly different between people with and without alzheimer s disease health related quality of life following adolescent sports related concussion or fracture a prospective cohort study quality of life in adolescents recovering from sports related concussion or fracture ocean acidification affects fish spawning but not paternity at co seeps first evidence of ocean acidification s impact on reproductive behavior in wild fish beneficial effects of il after spinal cord injury in mice protein found that improves mobility after spinal cord injuries lower energy density diets are associated with higher monetary costs per kilocalorie and are consumed by women of higher socioeconomic status people of higher socioeconomic status choose better diets but pay more per calorie reinstatement of varanus douarrha lesson as a valid species with comments on the zoogeography of monitor lizards squamata varanidae in the bismarck archipelago papua new guinea long lost monitor lizard re discovered on papua new guinean island first evidence that marine protected areas can work for marine mammals size matters large marine protected areas work for dolphins acupuncture for chemotherapy induced peripheral neuropathy cipn a pilot study using neurography acupuncture may ease severe nerve pain associated with cancer treatment study suggests the global distribution of diet breadth in insect herbivores global patterns of specialized feeding in insect herbivores revealed influenza virus infectivity is retained in aerosols and droplets independent of relative humidity flu virus is protected by mucus when airborne regardless of humidity bruton s tyrosine kinase btk function is important to the development and expansion of chronic lymphocytic leukemia cll study confirms target of potent chronic leukemia drug generation of distal airway epithelium from multipotent human foregut stem cells scientists grow mini lungs to aid study of cystic fibrosis evaluating a parainfluenza virus based vaccine in a host with pre existing immunity against parainfluenza virus man s best friend common canine virus may lead to new vaccines for deadly human diseases antarctic ice sheet discharge driven by atmosphere ocean feedbacks at the last glacial termination climate change could trigger strong sea level rise increased gender variance in autism spectrum disorders and attention deficit hyperactivity disorder wishing to be another gender links to adhd autism spectrum disorders high riverine co emissions at the permafrost boundary of western siberia greenhouse emissions from siberian rivers peak as permafrost thaws sports participation in genotype positive children with long qt syndrome study re examines sports restrictions for children with heart rhythm disorder identification of causal genetic drivers of human disease through systems level analysis of regulatory networks gene that drives aggressive brain cancer found by new computational approach just add a verse from the quran effects of religious rhetoric in gain and loss framed anti alcohol messages with a palestinian sample religious rhetoric not helpful in anti alcohol messages topical simvastatin accelerates wound healing in diabetes by enhancing angiogenesis and lymphangiogenesis topical simvastatin shown to accelerate wound healing in diabetes association of brain structure changes and cognitive function with combination antiretroviral therapy in hiv positive individuals brain structure cognitive function in treated hiv positive individuals sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node positive breast cancer surgical procedure examined in detecting cancer in lymph nodes near breast sex differences in biopsychosocial correlates of binge eating disorder a study of treatment seeking obese adults in primary care setting binge eating more likely to lead to health risks in men disrupted brain circuitry for pain related reward punishment in fibromyalgia pleasure pain brain signals disrupted in fibromyalgia patients heat induced perfect light absorption in thin film metasurfaces for structural coloring invited thermally painted metasurfaces yield perfect light absorbers for high tech applications shared genetic etiology underlying alzheimer s disease and type diabetes researchers identify genetic markers linking risk for both type diabetes alzheimer s disease detection of an observed year ocean temperature change from limited data century old ocean data provides further confirmation of global warming decreased cortical representation of genital somatosensory field after childhood sexual abuse specific changes in brain structure after different forms of child abuse prevalence of human caused mortality in an unhunted cougar population and potential impacts to management humans responsible for of cougar deaths in re established populations food grade tio impairs intestinal and systemic immune homeostasis initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon food additive e first findings of oral exposure to titanium dioxide nanoparticles mouse tmem mutation reveals a mechanism involving mitochondrial dynamics that leads to age dependent retinal pathologies new protein provides critical link between aging and age dependent disease structure of influenza a polymerase bound to the viral rna promoter flu virus key machine first complete view of structure revealed human rpe stem cells grown into polarized rpe monolayers on a polyester matrix are maintained after grafting into rabbit subretinal space stem cell replacement for frequent age related blindness childhood infections and subsequent school achievement among danish children childhood infections may have lasting effects on school performance dihydrosphingomyelin impairs hiv infection by rigidifying liquid ordered membrane domains new cellular armor developed to prevent infection by aids virus factors associated with death or hospitalization due to pandemic influenza a h n infection in california report on h n cases in california shows hospitalization can occur at all ages with many severe direct mass spectrometry analysis of biofluid samples using slug flow microextraction nano electrospray ionization new technique yields fast results in drug biomedical testing contribution of hydroxymethane sulfonate to ambient particulate matter a potential explanation for high particulate sulfur during severe winter haze in beijing a clearer path to clean air in china local disease control for spinal metastases following separation surgery and adjuvant hypofractionated or high dose single fraction stereotactic radiosurgery outcome analysis in patients controlling spine metastases with tumor separation surgery and high dose stereotactic radiosurgery high throughput identification and rational design of synergistic small molecule pairs for combating and bypassing antibiotic resistance finding the perfect match new approach to battle drug resistant bacteria the introduction of dengue vaccine may temporarily cause large spikes in prevalence use of dengue vaccine may cause short term spikes in its prevalence flexible energetics of cheetah hunting strategies provide resistance against kleptoparasitism humans to blame for plummeting numbers of cheetahs ectopic expression of p cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo colon cancer researchers take important steps forward in understanding cause increasing incidence of colorectal cancer in young adults in europe over the last years bowel cancer rising among young adults in europe predators modify the evolutionary response of prey to temperature change predators key to helping prey evolve with climate change reachability improvement of a climbing robot based on large deformations induced by tri tube soft actuators inspired by a soft body of a leech a wall climbing robot answers at your fingertips access to the internet influences willingness to answer questions access to the internet makes us less willing to say we know things synthetic polymer coatings for long term growth of human embryonic stem cells new culture dish could advance human embryonic stem cell research how costs and heterogeneous consumer price sensitivity interact with add on pricing cost savings from add on pricing may result in profit loss association between index to ring finger length ratio and risk of severe knee and hip osteoarthritis requiring total joint replacement a lower ratio between index ring fingers is associated with higher risk of developing severe osteoarthritis in the knee says study effectiveness of surgery for lumbar stenosis and degenerative spondylolisthesis in the octogenarian population analysis of the spine patient outcomes research trial sport data is surgery a viable treatment option for patients age with acute spinal conditions ? human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines differences in immune responses due to age sex and genetics herv h rna is abundant in human embryonic stem cells and a precise marker for pluripotency retrovirus in the human genome is active in pluripotent stem cells microseismicity linked to gas migration and leakage on the western svalbard shelf listening for micro earthquakes hearing mega whales in the arctic selective killing of mixed lineage leukemia cells by a potent small molecule dot l inhibitor epigenetic pathway and new drug show promise in reversing a hard to treat childhood cancer regulation of head and neck squamous cancer stem cells by pi k and sox seven year study pays off with most detailed picture of head and neck cancer stem cells to date spatial and temporal variations in resilience to tropical cyclones along the united states coastline as determined by the multi hazard hurricane impact level model beyond wind speed a new measure for predicting hurricane impacts association of state laws and healthcare workers influenza vaccination rates state laws boost flu vaccination rates in health care workers regional protein expression in human alzheimer s brain correlates with disease severity biggest ever map of human alzheimer s brain bottom trawl fishing footprints on the world s continental shelves high res data offer most detailed look yet at trawl fishing footprint around the world epigenetic profiling to classify cancer of unknown primary a multicentre retrospective analysis first epigenetic test to diagnose tumors of unknown origin pth induces systemically administered mesenchymal stem cells to migrate to and regenerate spine injuries combining adult stem cells with hormone may speed bone fracture healing mineralogic evidence for subglacial volcanism in the sisyphi montes region of mars minerology on mars points to a cold and icy ancient climate early childhood television viewing predicts explosive leg strength and waist circumference by middle childhood tv habits predict kids waist size and sporting ability five and minute apgar scores and risks of cerebral palsy and epilepsy population based cohort study in sweden apgar scores in neonates predict risk of cp and epilepsy kataegis expression signature in breast cancer is associated with late onset better prognosis and higher her levels gene mutation hotspots linked to better breast cancer outcomes cap binding and immune evasion revealed by lassa nucleoprotein structure structure of lassa virus protein reveals viral thievery spatial analysis of urban flooding and extreme heat hazard potential in portland or low income neighborhoods more vulnerable to flooding extreme heat a neural crest origin for cohesinopathy heart defects zebrafish study sheds new light on human heart defects parp and phospho p protein expression is increased in human her positive breast cancers study points to possible new treatment for her breast cancer antidepressant use in late gestation and risk of postpartum haemorrhage a retrospective cohort study no long term effects of antidepressant use during pregnancy breast cancer risk in relation to the interval between menopause and starting hormone therapy hormone therapy begun at menopause may pose risk for breast cancer levels of infants urinary arsenic metabolites related to formula feeding and weaning with rice products exceeding the eu inorganic arsenic standard new research shows illegal levels of arsenic found in baby foods on demand optogenetic control of spontaneous seizures in temporal lobe epilepsy neuroscientists create fiber optic method of arresting epileptic seizures hofstadter s butterfly and the fractal quantum hall effect in moir superlattices first direct proof of hofstadter butterfly fractal observed in moir superlattices telomere length in newborns is related to maternal stress during pregnancy maternal stress during pregnancy could influence the biological clock for aging targeting src family kinases inhibits bevacizumab induced glioma cell invasion combo of avastin second drug shows promise fighting brain cancer early pastoral economies along the ancient silk road biomolecular evidence from the alay valley kyrgyzstan major corridor of silk road already home to high mountain herders over years ago the franklin expedition what sequential analysis of hair reveals about lead exposure prior to death strands of hair from member of franklin expedition provide new clues into mystery insomnia symptoms and risk for unintentional fatal injuries the hunt study insomnia increases risk of motor vehicle deaths other fatal injuries mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease systematic review and meta analysis of randomised controlled trials safety concern with mist inhalers for delivering common drug for chronic lung disease structural insights into mitochondrial calcium uniporter regulation by divalent cations scientists discover structural clues to calcium regulation in cells self sustaining closed loop multienzyme mediated conversion of amines into alcohols in continuous reactions self sustaining loop of chemical reactions could revolutionize drug production designer protein delivery from natural to engineered affinity controlled release systems tailored protein binding opens possibilities for nerve tissue treatments communicating the risk of injury in schoolboy rugby using poisson probability as an alternative presentation of the epidemiology schoolboy rugby risk of suffering an injury during a single season can be high uk study shows finding influential nodes for integration in brain networks using optimal percolation theory rare in vivo study shows weak brain nodes have strong influence on memory network american college of rheumatology recommendations for the use of nonbiologic and biologic disease modifying antirheumatic drugs in rheumatoid arthritis american college of rheumatology presents recommendations for rheumatoid arthritis therapy exosomes from marrow stromal cells expressing mir b inhibit glioma growth novel effective brain cancer treatment using genetic material from bone marrow cells the effect of carpal tunnel release on typing performance broken shoulder leads to carpal tunnel syndrome surgery study longitudinal relationships between caloric expenditure and gray matter in the cardiovascular health study different kinds of physical activity shown to improve brain volume cut alzheimer s risk in half first report of seedling blight of eastern poison ivy toxicodendron radicans bycolletotrichum fioriniaein virginia weeding out pesky poison ivy with discovery of killer fungus effect on gastric function and symptoms of drinking wine black tea or schnapps with a swiss cheese fondue randomised controlled crossover trial drinking alcohol during a rich meal slows down digestion but doesn t increase indigestion study finds asthma and cigarette smoking in a representative sample of adults links between asthma smoking and nicotine dependence explored in new study effect of donor kir dl allelic polymorphism on the outcome of pediatric allogeneic hematopoietic stem cell transplantation immune system marker tied to improved bone marrow transplant outcomes reacting to the scope of a data breach the differential role of fear and anger fearful customers sensitive to size and scope of a data breach while angry customers are not f fdg pet reveals frontotemporal dysfunction in children with fever induced refractory epileptic encephalopathy pet scans provide insight into fever induced epilepsy in children motorboat noise impacts parental behaviour and offspring survival in a reef fish motor boat noise makes fish bad parents leading to the death of their babies mining the glycocode exploring the spatial distribution of glycans in gastrointestinal mucin using force spectroscopy scientists use the force atomic force microscopy to decode secrets of our gut variation in prolactin is related to variation in sexual behavior and contact affiliation hormone known for mother s milk also fosters bond between parents impact of ocean phytoplankton diversity on phosphate uptake biology trumps chemistry in open ocean how phytoplankton assimilate limited concentrations of phosphorus frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrentclostridium difficileinfection frozen vs. fresh fecal transplantation for c. diff. infection shows similar effectiveness does blue uniform color enhance winning probability in judo contests ? color of judo uniform has no effect on winning adaptive vaccination strategies to mitigate pandemic influenza mexico as a case study study links real time data to flu vaccine strategies cardiorespiratory fitness and white matter neuronal fiber integrity in mild cognitive impairment poor fitness linked to weaker brain fiber higher dementia risk vaccine induced antibodies that neutralize group and group influenza a viruses vaccine strategy induces antibodies that can target multiple influenza viruses cntf mediated preactivation of astrocytes attenuates neuronal damage and epileptiform activity in experimental epilepsy epileptic fits are like raging thunderstorms astrocytes help reduce long term damage surprising new research shows beer classification by means of a potentiometric electronic tongue robot with a taste for beer ? electronic tongue can identify brands of beer facial structure is a reliable cue of aggressive behavior angry faces facial structure linked to aggressive tendencies study suggests emergency department visits for concussion in young child athletes concussions in young athletes on the rise especially in hockey and football players periodic trends in olefin epoxidation over group iv and v framework substituted zeolite catalysts a kinetic and spectroscopic study metal ion catalysts and hydrogen peroxide could green up plastics production ancient dna reveals the arctic origin of viking age cod from haithabu germany dna from viking cod bones suggests year history of european fish trade use of hormone replacement therapy and risk of venous thromboembolism nested case control studies using the qresearch and cprd databases hrt tablets associated with increased risk of blood clots comment on drought induced reduction in global terrestrial net primary production from through claims of drought driven declines in plant productivity global food security refuted modeling errors produced exaggerated claims signatures of post zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer new method to predict increased risk of non familial breast cancer myxoma virus m is a specific inhibitor of rabbit pkr but contains a loss of function mutation in australian virus isolates a real peter rabbit tale biologists find key to myxoma virus rabbit coevolution electrically activated conductivity and white light emission of a hydrocarbon nanoring iodine assembly shining rings a new material emits white light when exposed to electricity neural mechanisms of behavioral change in young adults with high functioning autism receiving virtual reality social cognition training a pilot study social awareness increases demonstrate brain changing in adults with autism sp osterix is restricted to bone forming vertebrates where it acts as a dlx co factor in osteoblast specification study identifies a key to bone formation vertebrate evolution deep eutectic solvents for cathode recycling of li ion batteries new blue green solution for recycling world s batteries crop pests and pathogens move polewards in a warming world spread of crop pests threatens global food security as earth warms hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis a randomised double blind placebo controlled phase trial high calorie diet could slow progression of motor neuron disease als study finds embryonic stem cell proliferation stimulated by altered anabolic metabolism from glucose transporter transported glucosamine finding new clues to a sugar suspect in birth defects platelet activation suppresses hiv infection of t cells platelet activation inhibits the host cell entry of hiv snakebite enquiries to the uk national poisons information service around two queries a week to uk poisons service concern... snakebites effectiveness of the international phytosanitary standard ispm no. on reducing wood borer infestation rates in wood packaging material entering the united states international standards significantly reducing insect stowaways in wood packaging material new sivaladapid primate from lower siwalik deposits surrounding ramnagar jammu and kashmir state india newfound primate teeth take a big bite out of the evolutionary tree of life does low energy sweetener consumption affect energy intake and body weight ? a systematic review including meta analyses of the evidence from human and animal studies low energy sweeteners help reduce energy intake and body weight evidence shows comparing fmri activation during smooth pursuit eye movements among contact sport athletes non contact sport athletes and non athletes brain differences in athletes playing contact vs. noncontact sports severity of metabolic syndrome as a predictor of cardiovascular disease between childhood and adulthood new test predicts teens future risk of heart disease population resilience to an extreme drought is influenced by habitat area and fragmentation in the local landscape uk butterfly populations threatened by extreme drought and landscape fragmentation neural network underlying intermanual skill transfer in humans new virtual reality technology may improve motor skills in damaged limbs insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis colorectal cancer jumping gene named sleeping beauty plays vital role in investigating cancer pathway generation of an epigenetic signature by chronic hypoxia in prostate cells epigenetic signature changes in low oxygen levels may contribute to prostate cancer development tumor size and stage of breast cancer in c te d ivoire and republic of congo results from population based cancer registries high proportion of advanced breast cancers in sub saharan africa influenza vaccination rates in children decline when the live attenuated influenza vaccine is not recommended flu vaccine rates for kids may drop when the nasal spray vaccine is unavailable annual rhythms of milk and milk fat and protein production in dairy cattle in the united states annual biological rhythms govern milk production in dairy cows genome wide crispr cas screen identifies host factors essential for influenza virus replication genetic screening tool identifies how the flu infiltrates cells early impact of human papillomavirus vaccination on cervical neoplasia nationwide follow up of young danish women hpv vaccination associated with reduced risk of cervical lesions in denmark an exploration of weekly patterns in hiv related behaviors implications for successful interventions and future research hiv prevention and risk behaviors follow weekly patterns identification of lynch syndrome among patients with colorectal cancer study identifies strategy for improved screening for type of hereditary colorectal cancer distinct genetic risk based on association of met in families with co occurring autism and gastrointestinal conditions gene variant associated with both autism and gastrointestinal dysfunction analogue spin orbit torque device for artificial neural network based associative memory operation the world s first demonstration of spintronics based artificial intelligence a mid cretaceous tyrannosauroid and the origin of north american end cretaceous dinosaur assemblages new three foot tall relative of tyrannosaurus rex the political divide on climate change partisan polarization widens in the u.s. data shows increasing political polarization on climate change a cross sectional description of age and gender differences in exercise patterns in adults living with hiv along with antiretroviral medications doctors may prescribe exercise for people with hiv genetically modified pigs are protected from classical swine fever virus genetically modified pigs resist infection with the classical swine fever virus magnetic turbulence in a table top laser plasma relevant to astrophysical scenarios table top plasma gets wind of solar turbulence prospective multicenter randomized crossover clinical trial comparing the safety and effectiveness of cooled radiofrequency ablation with corticosteroid injection in the management of knee pain from osteoarthritis noninvasive procedure is superior to steroid injection for painful knee osteoarthritis pathologically confirmed chronic traumatic encephalopathy in a year old former college football player chronic traumatic encephalopathy in year old former football player interest exceeds understanding in public support of bee conservation bee informed public interest exceeds understanding in bee conservation modulation of light enhancement to symbiotic algae by light scattering in corals and evolutionary trends in bleaching insights into deadly coral bleaching could help preserve reefs surprising result from study of world s fair corals socioeconomic status and adverse birth outcomes a population based canadian sample maternal marijuana use linked to low birth weight optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia study suggests approach to waking patients after surgery ground level falls are associated with significant mortality in elderly patients for elderly even short falls can be deadly adults plus three times as likely to die following low level falls bortezomib induced unfolded protein response increases oncolytic hsv replication resulting in synergistic anti tumor effects. low dose of targeted drug might improve cancer killing virus therapy mental health problems in a community after the great east japan earthquake in high rates of ptsd and other mental health problems after great east japan earthquake cardiometabolic effects of genetic upregulation of the interleukin receptor antagonist a mendelian randomisation analysis million person study examines long term effects of blocking inflammation does aircraft noise exposure increase the risk of hypertension in the population living near airports in france ? long term exposure to aircraft noise linked to high blood pressure facile fabrication of large area atomically thin membranes by direct synthesis of graphene with nanoscale porosity synergy in two dimensional materials membranes research clear in professor s new work development of white matter circuitry in infants with fragile x syndrome fragile x imaging study reveals differences in infant brains magnetic field induced t cell receptor clustering by nanoparticles enhances t cell activation and stimulates antitumor activity magnetic medicine nanoparticles target cancer fighting immune cells generational differences in the year incidence of age related macular degeneration large decrease in age related macular degeneration in baby boomers compared to previous generations deciduous autologous tooth stem cells regenerate dental pulp after implantation into injured teeth regrowing dental tissue with stem cells from baby teeth human colostrum and breast milk contain high levels of tnf related apoptosis inducing ligand trail high levels of trail protein in breast milk might contribute to anticancer activity approximate bayesian computation with deep learning supports a third archaic introgression in asia and oceania artificial intelligence applied to the genome identifies an unknown human ancestor inheritance of stress induced atf dependent epigenetic change mechanism for stress induced epigenetic inheritance uncovered in new study alcohol consumption and prevalence of human papillomavirus hpv infection among us men in the hpv in men him study high alcohol intake linked to heightened hpv infection risk in men clinical utility of genomic analysis in adults with idiopathic liver disease genetic analysis has potential to transform diagnosis and treatment of adults with liver disease of unknown cause toppled television sets and head injuries in the pediatric population a framework for prevention pediatric injuries from toppled tv sets risk factors strategies for prevention mek inhibitor withdrawal reverses acquired resistance driven by brafv e amplification whereas krasg d amplification promotes emt chemoresistance tumor cells drug addiction may be their downfall how credit card payments increase unhealthy food purchases visceral regulation of vices cash is healthier ? credit and debit increase impulsive food purchases cloud based simulations on google exacycle reveal ligand modulation of gpcr activation pathways key drug receptor atom level simulation of a g protein coupled receptor could lead to improved drug design effect of age on the efficacy and safety of lenvatinib in radioiodine refractory differentiated thyroid cancer in the phase iii select trial inhibitor drug improves overall survival in older radioiodine resistant thyroid cancer estimating the vulnerability of fifteen tree species under changing climate in northwest north america climate change causing massive movement of tree species across the west comprehensive analysis of sorption enhanced steam methane reforming in a variable volume membrane reactor four stroke engine cycle produces hydrogen from methane captures carbon dioxide contraband cigarette consumption among adolescent daily smokers in ontario canada contraband cigarettes main source of supply for ontario youth study finds first borns have greater bmi and are more likely to be overweight or obese a study of sibling pairs among swedish women firstborn women more likely to be overweight obese as adults than second born sisters temperature phased conversion of acid whey waste into medium chain carboxylic acids via lactic acid no external e donor converting waste water from dairies to animal feed and aviation fuel mobile phone incentives for childhood immunizations in rural india pairing mobile phone reminders with incentives to help prevent diseases candida albicans ume a filament specific transcriptional regulator directs hyphal growth via a pathway involving hgc cyclin related protein microbiologists find source of fungus s damaging growth a model of care for healthy menopause and ageing emas position statement new model of care for healthy menopause and aging combined cognitive bias modification treatment for social anxiety disorder a pilot trial computerized anxiety therapy found helpful in small trial a mineralogical signature for burgess shale type fossilization soft tissue fossil clues could help search for ancient life on earth and other planets the current unlikely earthquake hiatus at california s transform boundary paleoseismic sites california s current earthquake hiatus is an unlikely pause global analysis of the fungal microbiome in cystic fibrosis patients reveals loss of function of the transcriptional repressor nrg as a mechanism of pathogen adaptation new light shed on mysterious fungus that has major health consequences impact of soil moisture and temperature on potato production using seepage and center pivot irrigation irrigation method saves percent of water needed for potato growth self assembled dna nanoclews for the efficient delivery of crispr cas for genome editing dna clews used to shuttle crispr cas gene editing tool into cells induction of erythropoiesis using human vascular networks genetically engineered for controlled erythropoietin release engineered drug secreting blood vessels reverse anemia in mice intramolecular c analysis of tree rings provides multiple plant ecophysiology signals covering decades tree rings provide vital information for improved climate predictions stromatolites on the rise in peat bound karstic wetlands ancient life form discovered in remote tasmanian valley depression and risk of hospitalisations and rehospitalisations for ambulatory care sensitive conditions in denmark a population based cohort study depression contributes to preventable hospitalizations in danish study calcium intake is not associated with increased coronary artery calcification the framingham study no link found between calcium intake and coronary artery calcification object vision to hand action in macaque parietal premotor and motor cortices from vision to hand action neuroscientists decipher how our brain controls grasping movements organic matter loading by hippopotami causes subsidy overload resulting in downstream hypoxia and fish kills hippo waste causes fish kills in africa s mara river germline gain of function mutations in aff cause a developmental syndrome functionally linking the super elongation complex and cohesin new genetic syndrome found arising from errors in master switch during early development activator inhibitor coupling between rho signalling and actin assembly makes the cell cortex an excitable medium collaborative research reveals a new view of cell division fingolimod phosphate inhibits astrocyte inflammatory activity in mucolipidosis iv in child crippling mucolipidosis iv drug shows hope in lab cultures benefits of regulating hazardous air pollutants from coal and oil fired utilities in the united states benefits associated with the reduction of mercury emissions far outweigh industry cost autistic like behaviour in scn a mice and rescue by enhanced gaba mediated neurotransmission low dose sedative alleviates autistic like behavior in mice with dravet syndrome mutation sex determination mode does not affect body or genital development of the central bearded dragon pogona vitticeps girls will be boys sex reversal in dragon lizards genome wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non glioblastoma tumors new genetic risk factors identify two distinct glioma subtypes impact of current smoking and alcohol consumption on gastrostomy duration in patients with head and neck cancer undergoing definitive chemoradiotherapy effect of smoking alcohol on feeding tube duration in head neck cancer patients rapid selection of oseltamivir and peramivir resistant pandemic h n during therapy in two immunocompromised hosts rapid development of drug resistant h n influenza reported in two cases sensory ataxic neuropathy in golden retriever dogs is caused by a deletion in the mitochondrial trnatyr gene neurological disorder in golden retriever dogs caused by a mutation in mitochondrial dna genomewide snp data reveal cryptic phylogeographic structure and microallopatric divergence in a rapids adapted clade of cichlids from the congo river congo river fish evolution shaped by intense rapids autophagic clearance of polyq proteins mediated by ubiquitin atg adaptors of the conserved cuet protein family new cellular garbage control pathway with relevance for human neurodegenerative diseases gender differences in physiologic markers and health behaviors associated with childhood obesity school lunch and tv time linked with childhood obesity size doesn t matter cortical stroke lesion volume is not associated with upper extremity motor impairment and function in mild chronic hemiparesis stroke recovery theories challenged by new studies looking at brain lesions bionic arms evidence for hand size constancy the dominant hand as a natural perceptual metric hand size appears to stay constant providing natural ruler scripting sexual consent internalized traditional sexual scripts and sexual consent expectancies among college students sexual stereotypes can lead to unhealthy sexual relationships persistent lcmv infection is controlled by blockade of type i interferon signaling scientists find interferon one of the body s own proteins induces persistent viral infection plants and soil microbes respond to recent warming on the antarctic peninsula on warming antarctic peninsula moss and microbes reveal unprecedented ecological change an experimental replication on the effect of the practice of mindfulness in conceptual modeling performance the beneficial aspects of mindfulness for students of computer engineering myxoma virus suppresses proliferation of activated t lymphocytes yet permits oncolytic virus transfer to cancer cells rabbit virus improves bone marrow transplants kills some cancer cells ascorbic acid thiamin riboflavin and vitamin b contents vary between sweetpotato tissue types sweet potato leaves a good source of vitamins adenosine deaminase regulates treg expression in autologous t cell dendritic cell cocultures from patients infected with hiv adenosine deaminase may help the immune system fight hiv on its own protein misfolding occurs by slow diffusion across multiple barriers in a rough energy landscape solving the next step in the mystery of prions inclined zenith aurora over kyoto on september graphical evidence of extreme magnetic storm extreme magnetic storm red aurora over kyoto in maximizing future potential in physics and stem evaluating a summer program through a partnership between science outreach and education research pre college science programs lead to more science majors origin and functional prediction of pollen allergens in plants genomics study points to origins of pollen allergens monitoring the growth of the neural representations of new animal concepts scientists gain first glimpse of new concepts developing in the brain virus like particle display of her induces potent anti cancer responses new vaccine technique effectively fights breast cancer in mice social isolation and loneliness as risk factors for myocardial infarction stroke and mortality uk biobank cohort study of men and women known risk factors largely explain links between loneliness and first time heart disease stroke evaluating patterns of a white band disease wbd outbreak in acropora palmata using spatial analysis a comparison of transect and colony clustering geographic analysis offers new insight into coral disease spread randomized clinical trial of deep brain stimulation for poststroke pain first randomized controlled trial of deep brain stimulation for chronic pain shows promise body mass index not dyslipidemia is an independent predictor of survival in als mild obesity appears to improve survival in amyotrophic lateral sclerosis patients leaky ryr channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death leaky calcium triggers brainstem blackout that results in sudden cardiac death editorial betaretrovirus in biliary epithelia of patients with autoimmune and cryptogenic liver disease authors reply researchers wind up a year old debate on betaretrovirus infection in humans training the approximate number system improves math proficiency practice at guesstimating can speed up math ability the amaryllidaceae alkaloid haemanthamine binds the eukaryotic ribosome to repress cancer cell growth daffodils to fight cancer anti cancer effect of a daffodil extract predictive modeling of coral distribution and abundance in the hawaiian islands abundance and distribution of hawaiian coral species predicted by model use of nonsteroidal anti inflammatory drugs predicts improved patient survival for pik ca altered head and neck cancer common pain reliever can improve survival in head and neck cancer metal doped organic aerogels for photocatalytic degradation of trimethoprim scientists developed a method that allows removal of antibiotic residue from waste water pulse characteristics of a direct antenna modulation transmitter new study demonstrates radio signal benefits from decades old theory sensitivity to the evaluation of others emerges by months sensitivity to how others evaluate you emerges by months a mammalian enhancer trap resource for discovering and manipulating neuronal cell types trapping individual cell types in the mouse brain ezetimibe reduces enlarged prostate in an animal model of benign prostatic hyperplasia cholesterol lowering drug shrinks enlarged prostates in hamster model an alternative pluripotent state confers interspecies chimaeric competency new stem cells hold potential for generating mature functional tissues an integrative study of protein rna condensates identifies scaffolding rnas and reveals players in fragile x associated tremor ataxia syndrome rnas play key role in protein aggregation and in neurodegenerative disease bathymetric controls on pliocene north atlantic and arctic sea surface temperature and deepwater production underwater ridges impact ocean s flow of warm water findings to improve climate models adolescent expectations of early death predict adult risk behaviors teen survival expectations predict later risk taking behavior electrical brain stimulation induces dendritic stripping but improves survival of silent neurons after optic nerve damage current stimulation may keep visual neurons alive after injury but at a cost hydroxyglutarate detection by magnetic resonance spectroscopy in idh mutated patients with gliomas diagnostic brain tumor test could revolutionize care of patients with low grade gliomas p her t cell bispecific antibody for breast cancer treatment t cell bispecific antibody for the immune mediated killing of her breast cancer cells insulin signaling regulates oocyte quality maintenance with age via cathepsin b activity fertility breakthrough new research could extend egg health with age incidence and predictors of critical events during urgent air medical transport one in patients experience critical event during urgent air medical transport white matter naa cho and cho cr ratios at mr spectroscopy are predictive of motor outcome in preterm infants brain chemical ratios help predict developmental delays in preterm infants an agent based model of leukocyte transendothelial migration during atherogenesis multiscale modeling reveals key events during early atherosclerotic plaque development anthropogenic impacts on mosquito populations in north america over the past century growing mosquito populations linked to urbanization ddt s slow decay effectiveness of a grass roots statewide enrichment program for gifted elementary school children successful promotion of giftedness as early as elementary school age anthropogenic carbon release rate unprecedented during the past million years human carbon release rate is unprecedented in the past million years of earth s history reptiles from len is maranhenses national park maranh o northeastern brazil travels in northeastern brazil unfolding the reptile fauna of len is maranhenses geometric determinants of in situ direct laser writing new d nanoprinting strategy opens door to revolution in medicine robotics prenatal exposure to recreational drugs affects global motion perception in preschool children vision test gives insight into the effect of prenatal exposure to recreational drugs integrated local binary pattern texture features for classification of breast tissue imaged by optical coherence microscopy robot radiology low cost a.i. could screen for cervical cancer better than humans pathogen effectors target arabidopsis eds and alter its interactions with immune regulators researchers identify key plant immune response in fight against bacteria chronic oral methylphenidate treatment reversibly increases striatal dopamine transporter and dopamine type receptor binding in rats nonprescription use of ritalin linked to adverse side effects study finds fluorescence activated cell sorting via a focused traveling surface acoustic beam single cell level sorting technology uses sound waves breast and cervical cancer in countries between and a systematic analysis more women dying from breast and cervical cancer at a younger age in developing countries generating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological genomic and protein interaction data clues to relationship between schizophrenia and rheumatoid arthritis assessment of the regional economic impacts of catastrophic events cge analysis of resource loss and behavioral effects of an rdd attack scenario costs of dirty bomb attack in los angeles enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer breast cancer fuelled by mysterious yin yang protein a high resolution human contact network for infectious disease transmission human networking theory gives picture of infectious disease spread sun protection practices and sun exposure among children with a parental history of melanoma children of melanoma survivors need better protection from sun s harmful rays clinical and genetic risk factors for acute pancreatitis in patients with acute lymphoblastic leukemia survival rates for patients at high risk of relapse of childhood leukemia improve with high doses of chemotherapy drug keto prostaglandin e activates host peroxisome proliferator activated receptor gamma ppar to promote cryptococcus neoformans growth during infection copycat fungus deceives immune system and deactivates body s response to infection impact of preoperative opioid use on total knee arthroplasty outcomes opioid use before knee replacement surgery results in worse pain outcomes for patients impact of oncology drug shortages on chemotherapy treatment cancer drug shortages result in almost no treatment changes irradiation of the potential cancer stem cell niches in the adult brain improves progression free survival of patients with malignant glioma irradiating stem cell niche doubles survival in brain cancer patients machine learning approaches distinguish multiple stress conditions using stress responsive genes and identify candidate genes for broad resistance in rice genes identified that could lead to tough disease resistant varieties of rice mid pliocene climate change amplified by a switch in indonesian subsurface throughflow from greenhouse to ice house important role of the indonesian gateway suggested association between methylphenidate and amphetamine use in pregnancy and risk of congenital malformations adhd med use during pregnancy and risk of birth defects serum hydroxyvitamin d plasma lipids and associated gene variants in prepubertal children high vitamin d levels linked to lower cholesterol in children imaging glial activation in patients with post treatment lyme disease symptoms a pilot study using c dpa pet new scan technique reveals brain inflammation associated with post treatment lyme disease syndrome do you believe it ? verbal suggestions influence the clinical and neural effects of escitalopram in social anxiety disorder a randomized trial patients expectations influence the effectiveness of ssri antidepressants long term implications of a short term policy redacting substance abuse data gap in substance abuse data could have long term implications vertical mantle flow associated with a lithospheric drip beneath the great basin dripping blob under western u.s. a hidden drip drip drip beneath earth s surface picocyanobacteria and deep ocean fluorescent dissolved organic matter share similar optical properties scientists begin to unlock secrets of deep ocean color from organic matter antigen specific b cell receptor sensitizes b cells to infection by influenza virus flu virus wipes out immune system s first responders to establish infection historical tropical forest reliance amongst the wanniyalaeto vedda of sri lanka an isotopic perspective evidence for persistent forest reliance by indigenous peoples in historical sri lanka projected response of the indian ocean dipole to greenhouse warming the indian cousin of el ni o the second climatic problem child molecular evolution of the hyaluronan synthase gene in mammals implications for adaptations to the subterranean niche and cancer resistance naked mole rats anti cancer gene is unique among mammals presentation on us hospital websites of risks and benefits of transcatheter aortic valve replacement procedures web based tavr marketing found to overstate benefits understate risks of procedure nonsteroidal anti inflammatory drugs alter the microbiota and exacerbate clostridium difficile colitis while dysregulating the inflammatory response how common pain relievers may promote clostridium difficile infections digital logic circuits in yeast with crispr dcas nor gates scientists borrow from electronics to build circuits in living cells prenatal alcohol exposure fasd and child behavior a meta analysis research pinpoints devastating impacts of fetal alcohol syndrome from the household to watershed a cross scale analysis of residential intention to adopt green stormwater infrastructure adoption of green stormwater infrastructure rises after floods low carbohydrate diets may increase risk of neural tube defects low carbohydrate intake to increased risk of birth defects zinc lozenges may shorten the duration of colds a systematic review zinc lozenges may shorten common cold duration finnish research suggests estrogen occurrence and persistence in vernal pools impacted by wastewater irrigation practices presence persistence of estrogens in vernal pools an emerging concern identification of essential oils with strong activity against stationary phase borrelia burgdorferi essential oils from garlic and other herbs kill persister lyme disease bacteria gastrointestinal effects of eating quinoa chenopodium quinoa willd. in celiac patients quinoa well tolerated in patients with celiac disease gps telemetry for parrots a case study with the kea nestor notabilis feasibility of tracking parrots with gps telemetry confirmed ending the epidemic of heterosexual hiv transmission among african americans continuing racial differences in hiv prevalence in u.s. synergistic action of dendritic mitochondria and creatine kinase maintains atp homeostasis and actin dynamics in growing neuronal dendrites mapping energy metabolism of growing nerve cells to better understand neuronal disorders simultaneously and synergistically harvest energy from the sun and outer space harvesting renewable energy from the sun and outer space at the same time long term evolution and transmission dynamics of swine influenza a virus long term study of swine flu viruses shows increasing viral diversity academic medical center leadership on pharmaceutical company boards of directors potential conflict of interest for leaders on pharmaceutical boards mediterranean unesco world heritage at risk from coastal flooding and erosion due to sea level rise world heritage sites threatened by rising sea levels trem lipid sensing sustains the microglial response in an alzheimer s disease model new target identified in fight against alzheimer s multiple sclerosis systematic discovery of germline cancer predisposition genes through the identification of somatic second hits big data analysis identifies new cancer risk genes preparticipation predictors for championship injury and illness cohort study at the beijing international association of athletics federations world championships athletes symptom anxiety linked to risk of injury marijuana use among patients with glaucoma in a city with legalized medical marijuana use study examines intent of glaucoma patients to use marijuana for treatment in city where legal claims for compensation after alleged birth asphyxia a nationwide study covering years human error most common cause of birth asphyxia poor fetal monitoring in of cases norwegian study shows rapid rule out of acute myocardial infarction with a single high sensitivity cardiac troponin t measurement below the limit of detection a collaborative meta analysis single high sensitivity troponin t result could quickly and safely rule out mi in the ed rise in electronic cigarette use among adolescents in poland significant rise in e cigarette use among youth in poland perfluorooctanoic acid perfluorooctanesulfonate and serum lipids in children and adolescents results from the c health project compounds in non stick cookware may be associated with elevated cholesterol in children and teens the stress regulator fkbp drives chronic pain by modulating spinal glucocorticoid signaling blocking stress protein relieves chronic pain in mice risk of hospitalization with neurodegenerative disease after moderate to severe traumatic brain injury in the working age population a retrospective cohort study using the finnish national health registries traumatic brain injury associated with dementia in working age adults survival in patients with colorectal cancer diagnosed by screening colonoscopy cancers caught during screening colonoscopy are more survivable glucose monitoring in diabetic dogs and cats adapting new technology for home and hospital care pioneering animal diabetes treatment researchers adapt human continuous glucose monitors for pets population growth is limited by nutritional impacts on pregnancy success in endangered southern resident killer whales orcinus orca high pregnancy failure nutritional stress in southern resident killer whales co expression profiling of autism genes in the mouse brain analysis of networked autism genes suggests functional role in the cerebellum differential associations of early callous unemotional oppositional and adhd behaviors multiple domains within early starting conduct problems ? preschoolers with low empathy at risk for continued problems effect of plant age and acibenzolar s methyl on development of downy mildew of basil early protection fungicide effectively reduce downy mildew in basil older primary care patients attitudes and willingness to screen for dementia majority of older adults willing to be screened by telephone for dementia increased persistent sodium current causes neuronal hyperexcitability in the entorhinal cortex of fmr knockout mice new explanation offered for symptoms of fragile x syndrome associations between dsm iv mental disorders and diabetes mellitus a role for impulse control disorders and depression independent association between diabetes depression and impulse control disorders including binge eating bulimia study shows antibiotic spider silk site specific functionalization of recombinant spider silk using click chemistry antibiotic spider silk for drug delivery regenerative medicine and wound healing silicon chip based mid infrared dual comb spectroscopy first chip scale broadband optical system that can sense molecules in mid infrared range a comparison of drill and broadcast methods for establishing cover crops on beds comparison study of planting methods shows drilling favorable for organic farming comparison of risk and age at diagnosis of myocardial infarction end stage renal disease and non aids defining cancer in hiv infected vs uninfected adults hiv infected adults diagnosed with age related diseases at similar ages as uninfected adults use of risk assessment instruments to predict violence and antisocial behaviour in samples involving people systematic review and meta analysis concerns over accuracy of tools to predict risk of repeat offending detecting regional anthropogenic trends in ocean acidification against natural variability unprecedented human made trends in ocean s acidity predaceous water beetles coleoptera hydradephaga of the lake st lucia system south africa biodiversity community ecology and conservation implications more than just hippos and crocs the hidden biodiversity of the isimangaliso wetland park thymosin as a restorative regenerative therapy for neurological injury and neurodegenerative diseases researchers propose novel new treatment of stroke other neurological diseases variation in wing characteristics of monarch butterflies during migration earlier migrants have redder and more elongated wings wing design proves key factor in determining migration success of monarch butterflies dicamba resistant kochia bassia scoparia in kansas characterization and management with fall or spring applied pre herbicides new insights on the control of dicamba resistant kochia no sweat african american adolescent girls opinions of hairstyle choices and physical activity some black teens may feel pulled between health and hair study shows regression of some high risk features of age related macular degeneration amd in patients receiving intensive statin treatment patients with macular degeneration show improvement with high dose statin treatment loss of caspase dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons potential way to protect neurons in parkinson s alzheimer s als therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon probiotic worm treatment may improve symptoms of colitis by restoring gut bacteria to healthy state endogenous control of waking brain rhythms induces neuroplasticity in humans first direct evidence of neuroplastic changes following brainwave training inhibition of ephb ephrin b signaling enhances response to cetuximab radiation therapy in head and neck cancers new combination treatment against relapsed head and neck cancer three dimensional study of alzheimer s disease hallmarks using the idisco clearing method d imaging reveals unexpected arrangement of plaques in alzheimer s afflicted brains survey of opinions about nutritional requirements of senior dogs and analysis of nutrient profiles of commercially available diets for senior dogs wide variety in nutritional content found in senior dog foods cascading predator effects in a fijian coral reef ecosystem fear of sharks influences seaweed growth on fijian coral reefs modeling the impact of vaccination control strategies on a foot and mouth disease outbreak in the central united states modeling the impact of a regional foot and mouth disease outbreak in livestock prenatal tobacco smoke exposure affects global and gene specific dna methylation changes in dna patterns are linked to prenatal smoke exposure one week of daily dosing with beetroot juice improves submaximal endurance and blood pressure in older patients with heart failure and preserved ejection fraction daily dose of beetroot juice improved endurance and blood pressure elevated markers of death receptor activated apoptosis are associated with increased risk for development of diabetes and cardiovascular disease death receptors new markers for type diabetes cardiovascular disease discriminative accuracy of f flortaucipir positron emission tomography for alzheimer disease vs other neurodegenerative disorders new method enables accurate diagnosis of alzheimer s disease citizen science reveals female sand tiger sharks carcharias taurus exhibit signs of site fidelity on shipwrecks sand tiger sharks return to shipwrecks off n.c. coast variation in rates of autoimmune thyroid disease by race ethnicity in us military personnel thyroid disease risk varies among blacks asians whites opinions from the front lines of cat colony management conflict why claws come out over feral cat management finding common ground among cat people and bird people docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta desaturase null mice lack of omega fatty acid linked to male infertility study suggests senolytics improve physical function and increase lifespan in old age senolytic drugs reverse damage caused by senescent cells in mice structure guided design of an anti dengue antibody directed to a non immunodominant epitope engineering potential treatment for all four dengue serotypes activated t lymphocytes are essential drivers of pathological remodeling in ischemic heart failureclinical perspective activated t cells drive post heart attack heart failure a gcase chaperone improves motor function in a mouse model of synucleinopathy drug used for another disease slows progression of parkinson s heritability of autism spectrum disorder in a uk population based twin sample heritability of autism spectrum disorder studied in uk twins clear sky visibility has decreased over land globally from to air pollution clear sky visibility over land has decreased globally indicative of increased particulate matter severe air pollution and labor productivity evidence from industrial towns in china severe air pollution affects the productivity of workers aerobic fitness in late adolescence and the risk of early death a prospective cohort study of. million swedish men obesity more dangerous than lack of fitness new study claims role of prongf p signaling in bladder dysfunction after spinal cord injury experimental drug restores some bladder function after spinal cord injury study finds leukaemia hijacks a neural mechanism to invade the central nervous system researchers solve mystery of how all enters the central nervous system best gene therapy corrects a diffuse retina wide microdetachment modulated by light exposure new gene therapy corrects a form of inherited macular degeneration in canine model method validation and application of a liquid chromatography tandem mass spectrometry method for drugs of abuse testing in exhaled breath first validated method of detecting drugs of abuse in exhaled breath an axial hox code controls tissue segmentation and body patterning in nematostella vectensis ancient past of a body plan code probed neoadjuvant endocrine therapy for estrogen receptor positive breast cancer presurgical endocrine therapy less toxic than chemotherapy for er positive breast cancer twentieth century hydroclimate changes consistent with human influence human influence on global droughts goes back years nasa study finds adaptations to submarine hydrothermal environments exemplified by the genome of nautilia profundicola genetic adaptations are key to microbe s survival in challenging environment metascape provides a biologist oriented resource for the analysis of systems level datasets new metascape platform enables biologists to unlock big data insights prostate specific antigen screening after us preventive services task force recommendations prostate cancer screening drops dramatically in middle aged men predictors of mental health and well being in employed adults with autism spectrum disorder at month follow up positive well being may protect against depression in people with autism prevalence of esr mutations in cell free dna and outcomes in metastatic breast cancer a secondary analysis of the bolero clinical trial prevalence of estrogen receptor mutations in patients with metastatic breast cancer the effects of content organization and curriculum implementation on students mathematics learning in second year high school courses non traditional mathematics curriculum results in higher standardized test scores reversed brain size sexual dimorphism accompanies loss of parental care in white sticklebacks fish study links brain size to parental duties liquid crystal enabled early stage detection of beta amyloid formation on lipid monolayers liquid crystals show potential for detection of neuro degenerative disease effects of intensive blood pressure lowering on cardiovascular and renal outcomes updated systematic review and meta analysis lowering blood pressure below current targets benefits a wide range of patients ttc ankk drd and chrna chrna chrnb influence different pathways leading to smoking behavior from adolescence to mid adulthood different genes influence smoking risk during adolescence and adulthood traditional and non traditional treatments for autism spectrum disorder with seizures an on line survey research reveals effectiveness of seizure treatments for children with autism attacks on health care in syria normalizing violations of medical neutrality ? has syria painted a target on medical teams around the world ? multivalent bi specific nanobioconjugate engager for targeted cancer immunotherapy new tumor shrinking nanoparticle to fight cancer prevent recurrence flexible navigation response in common cuckoos cuculus canorus displaced experimentally during migration cuckoo sheds new light on the scientific mystery of bird migration vessel architectural imaging identifies cancer patient responders to anti angiogenic therapy new mr analysis technique reveals brain tumor response to anti angiogenesis therapy the establishment of a marine focused biorefinery for bioethanol production using seawater and a novel marine yeast strain less drain on freshwater supplies with seawater fuel discovery clinical and fecal microbial changes with diet therapy in active inflammatory bowel disease novel diet therapy helps children with crohn s disease and ulcerative colitis reach remission rooting for cassava insights into photosynthesis and associated physiology as a route to improve yield potential scientists root for more cassava research to help meet greater demand for food soluble neuregulin modulates disease pathogenesis in rodent models of charcot marie tooth disease a potential therapy for incurable charcot marie tooth disease found transplantation of gabaergic interneurons into the neonatal primary visual cortex reduces absence seizures in stargazer mice neural transplant reduces absence epilepsy seizures in mice retrospective cues mitigate information loss in human cortex during working memory storage past memory cues help people juggle numerous pieces of information carbohydrate functionalized chitosan fiber for influenza virus capture new material for air cleaner filters that captures flu viruses detection and prevalence of boid inclusion body disease in collections of boas and pythons using immunological assays new test and better understanding of deadly infection in boas and pythons evidence for reduced autobiographical memory episodic specificity in cognitively normal middle aged and older individuals at increased risk for alzheimer s disease dementia autobiographical memory tested for early alzheimer s detection c peptide decline in type diabetes has two phases an initial exponential fall and a subsequent stable phase new hope from the seven year switch in type diabetes a randomized controlled trial of intranasal ketamine in major depressive disorder intranasal ketamine confers rapid antidepressant effect in depression sediment starvation destroys new york city marshes resistance to sea level rise urbanization is cutting off life support to new york city s wetlands an annotated checklist of the scale insects of iran hemiptera sternorrhyncha coccoidea with new records and distribution data peculiar diverse and dangerous to crops a checklist of the scale insects of iran effects of endogenous androgens and abdominal fat distribution on the interrelationship between insulin and non insulin mediated glucose uptake in females polycystic ovary syndrome puts glucose control in double jeopardy effects of oil and global environmental drivers on two keystone marine invertebrates combined local and global actions could lessen impacts of change in marine environment alterations in the plasma levels of specific choline phospholipids in alzheimer s disease mimic accelerated aging alzheimer s disease patients exhibit changes in certain blood lipids that are typical of premature ageing do self administered positive psychology exercises work in persons in recovery from problematic substance use ? an online randomized survey happiness exercises can boost mood in those recovering from substance use disorder environmental change drives accelerated adaptation through stimulated copy number variation directed gene copy variation the key to conquering new environments increasing neural stem cell division asymmetry and quiescence are predicted to contribute to the age related decline in neurogenesis brain confetti why our sense of smell declines in old age genome sequence of the olive tree olea europaea decoding the complete genome of the mediterranean s most emblematic tree the olive auditory somatosensory bimodal stimulation desynchronizes brain circuitry to reduce tinnitus in guinea pigs and humans specially timed signals ease tinnitus symptoms in first test aimed at the condition s root cause high resolution mapping of two large scale transpressional fault zones in the california continental borderland santa cruz catalina ridge and ferrelo faults little known quake tsunami hazards lurk offshore of southern california spatiotemporal control of intracellular phase transitions using light activated optodroplets new tool shines light on protein condensation in living cells cellular origin of bladder neoplasia and tissue dynamics of its progression to invasive carcinoma source of most cases of invasive bladder cancer identified evaluation of intestinal function in children with autism and gastrointestinal symptoms tests show no specific gastrointestinal abnormalities in children with autism fast whole brain three dimensional macromolecular proton fraction mapping in multiple sclerosis gray matter myelin loss strongly related to multiple sclerosis disability mri shows national regional and state level all cause and cause specific under mortality in india in a systematic analysis with implications for the sustainable development goals progress against child mortality lags in many indian states electroacupuncture and splinting versus splinting alone to treat carpal tunnel syndrome a randomized controlled trial electroacupuncture may help relieve pain from carpal tunnel syndrome shows randomized controlled trial conformational stability and catalytic activity of pten variants linked to cancers and autism spectrum disorders new insight into a fragile protein linked to cancer and autism onecut is essential for horizontal cell genesis and retinal integrity gene regulator is key to healthy retinal development and good vision in adulthood orthogonal self assembly of an organoplatinum ii metallacycle and cucurbit uril that delivers curcumin to cancer cells solving its insolubility researchers discover method to deliver curcumin to cancer cells intermittent breeding and the dynamics of resource allocation to reproduction growth and survival orsini s viper alternates between reproducing and growing year by year ablation of endothelial vegfr improves metabolic dysfunction by inducing adipose tissue browning mechanism that converts white fat to brown identified volcanic suppression of nile summer flooding triggers revolt and constrains interstate conflict in ancient egypt study reshapes understanding of climate change s impact on early societies non invasive determination of the complete elastic moduli of spider silks new light shed on the mysteries of spider silk clinical translation of a dual integrin v and gastrin releasing peptide receptor targeting pet radiotracer ga bbn rgd new type of pet imaging identifies primary and metastatic prostate cancer binocular ipad game vs patching for treatment of amblyopia in children ipad game effective in treating lazy eye in children a new parrot taxon from the yucat n peninsula mexico its position within genus amazona based on morphology and molecular phylogeny blue winged amazon a new parrot species from the yucat n peninsula enhancement of the zero phonon line emission from a single nitrogen vacancy center in a nanodiamond via coupling to a photonic crystal cavity nano diamond qubits and photonic crystals milestone reached on the path to integrated quantum technology agent based and phylogenetic analyses reveal how hiv moves between risk groups injecting drug users sustain the heterosexual epidemic in latvia hiv virus spread evolution studied through computer modeling insertional oncogenesis in patients after retrovirus mediated gene therapy of scid x why gene therapy caused leukemia in some boy in the bubble syndrome patients rest suppression mediates neural conversion of adult human fibroblasts via microrna dependent and independent pathways large scale production of living brain cells enables entirely new research an excitatory paraventricular nucleus to agrp neuron circuit that drives hunger surprising new clue to the roots of hunger neurons that drive appetite early antibiotic exposure and weight outcomes in young children small association between early antibiotic exposure and weight gain in young children aging related impairment of urine concentrating mechanisms correlates with dysregulation of adrenocortical angiotensin type receptors in male fischer rats aging may worsen the effects of a high salt diet how does accounting for worker productivity affect the measured cost effectiveness of lumbar discectomy ? back surgery offers long term societal benefits according to new study power transfer to a human during an electric eel s shocking leap electric eels leap to deliver painful taser like jolt hypovitaminosis d in patients scheduled to undergo orthopaedic surgery a single center analysis vitamin d deficiency rampant in patients undergoing orthopedic surgery damaging patient recovery relative risk of injury from acute alcohol consumption modeling the dose response relationship in emergency department data from countries heavy drinking women have higher risk of injury than men study shows a fluorogenic aggtag method based on halo and snap tag to simultaneously detect aggregation of two proteins in live cells new method uses fluorescence to identify disease causing forms of proteins regional nodal irradiation in early stage breast cancer additional radiation reduces breast cancer recurrence for some patients thermal physiology disease and amphibian declines on the eastern slopes of the andes disease not climate change fueling frog declines in the andes stakeholder perspectives on implementing a firearm safety intervention in pediatric primary care as a universal suicide prevention strategy introducing gun safety into health care providers checklists to prevent teen suicide high burden of homelessness among sexual minority adolescents findings from a representative massachusetts high school sample one in four gay or lesbian high school students is homeless massachusetts study finds environmental extremes versus ecological extremes impact of a massive iceberg on the population dynamics of a high level antarctic marine predator ecologists start new antarctic season comparing animals handling of adversity differences in prostate specific antigen testing among urologists and primary care physicians following the uspstf recommendations difference in psa testing among urologist primary care physician visits increased soluble phosphorus loads to lake erie unintended consequences of conservation practices ? adaptive management of soil conservation is essential to improving water quality p arf inhibits human glioblastoma induced angiogenesis by upregulating the expression of timp new pathway found for regulation of blood vessel growth in cancer trends in prescription opioids detected in fatally injured drivers in us states involvement of prescription opioids in fatal car crashes climbs sevenfold muscles provide an internal water reserve for reproduction animals can use muscle as an internal water source a citywide smoking ban reduced maternal smoking and risk for preterm not low birth weight births a colorado natural experiment citywide smoking ban reduced maternal smoking and preterm birth risk differential assessment of factor xa activity and global blood coagulability utilizing novel dielectric coagulometry stop that clot ! quantitative assessment of the blood coagulation cascade muscular strength in male adolescents and premature death cohort study of one million participants low muscle strength in adolescence linked to increased risk of early death the results of the study were published in the journal of cerebral blood flow and metabolism from the glass to the brain in six minutes coupling of rigor mortis and intestinal necrosis during c. elegans organismal death rigor mortis in worms offers new insight into death relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder brain stem volume linked to aggression in autism out of africa fossils shed light on the origin of the hoatzin an iconic neotropic bird across the atlantic on flotsam new fossil findings shed light on the origins of the mysterious bird hoatzin a connectome wide functional signature of transdiagnostic risk for mental illness breakdown of brain s visual networks linked to mental illness changing work and work family conflict evidence from the work family and health network increased employee flexibility supervisor support offer wide ranging benefits formulation of evidence based messages to promote the use of physical activity to prevent and manage alzheimer s disease exercising can protect the brain from alzheimer s disease programming of schwann cells by lats taz yap signaling drives malignant peripheral nerve sheath tumorigenesis study suggests way to attack deadly untreatable nerve tumors evaluation of computer generated reminders to improve cd laboratory monitoring in sub saharan africa a prospective comparative study electronic medical records improve quality of care in resource limited countries study suggests cafeteria diet impairs expression of sensory specific satiety and stimulus outcome learning junk food makes rats lose appetite for balanced diet long term mortality of patients surviving firearm violence gunshot survivors in high crime community face elevated risk of early death study shows human predation contributed to the extinction of the australian megafaunal bird genyornis newtoni ka ancient extinction of giant australian bird points to humans psychological processes underlying the association between childhood trauma and psychosis in daily life an experience sampling study abnormalities found in insight areas of the brain in anorexia seasonal variation of the radial brightness contrast of saturn s rings viewed in mid infrared by subaru comics saturn s rings viewed in the mid infrared show bright cassini division hormones in infant rhesus monkeys macaca mulatta hair at birth provide a window into the fetal environment hair from infants gives clues about life in womb poverty s most insidious damage the developing brain poverty s most insidious damage is to a child s brain relationship of body mass index with total mortality cardiovascular mortality and myocardial infarction after coronary revascularization evidence from a meta analysis obesity paradox cardiovascular mortality lowest among overweight patients using surface creep rate to infer fraction locked for sections of the san andreas fault system in northern california from alignment array and gps data some sections of the san andreas fault system in san francisco bay area are locked overdue substantial large scale feedbacks between natural aerosols and climate understanding the climate impact of natural atmospheric particles elevated maternal linoleic acid reduces circulating leptin concentrations cholesterol levels and male fetal survival in rat model don t overdo omega fat consumption during pregnancy fully implanted brain computer interface in a locked in patient with als paralyzed als patient operates speech computer with her mind real time imaging of single neuronal cell apoptosis in patients with glaucoma new eye test detects earliest signs of glaucoma managing concerning behaviors in patients prescribed opioids for chronic pain a delphi study managing concerning behaviors when opioids are taken for chronic pain hemoglobin a c targets for glycemic control with pharmacologic therapy for nonpregnant adults with type diabetes mellitus a guidance statement update from the american college of physicians moderate blood sugar control targets recommended for most patients with type diabetes evidence that the rab effector appl mediates app ctf induced dysfunction of endosomes in down syndrome and alzheimer s disease specific protein as missing link for earliest known change in alzheimer s pathology vancomycin ototoxicity a reevalutaion in an era of increasing doses increased dosage of vancomycin may lead to hearing loss in older patients a reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair immune cells in organ cavities play essential role in fast tissue repair the effects pcso a patented marine oil lipid and omega pufa blend derived from the new zealand green lipped mussel perna canaliculus on indirect markers of muscle damage and inflammation after muscle damaging exercise in untrained men a ra marine oil supplement has positive effects on post exercise muscle damage capture hi c reveals novel candidate genes and complex long range interactions with related autoimmune risk loci folding your genes new discovery sheds light on disease risk influence of statins on influenza vaccine response in elderly individuals studies raise questions about impact of statins on flu vaccination in seniors weight bearing estimation for cane users by using onboard sensors mechanized cane measures patients rehabilitation process without noticing it the effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation gut bacteria predict survival after stem cell transplant study shows prevalence and likelihood of meeting sleep physical activity and screen time guidelines among us youth teens too low on sleep activity and too high on screen time px rics deficient mice mimic autism spectrum disorder in jacobsen syndrome through impaired gabaa receptor trafficking mouse model yields possible treatment for autism like symptoms in rare disease what s normal ? influencing women s perceptions of normal genitalia an experiment involving exposure to modified and nonmodified images women s perceptions of normal female genitalia may be influenced by exposure to modified images preclinical validation and imaging of wnt induced repair in human d lung tissue cultures new method of investigating human lung tissue enables improved drug target validation for copd treatment two novel genomic regions associated with fearfulness in dogs overlap human neuropsychiatric loci overlapping genomic regions underlie canine fearfulness and human mental disorders online health awareness and technology affordance benefits for black female collegians maybe not online hiv prevention resources face resistance from black female college students myc drives progression of small cell lung cancer to a variant neuroendocrine subtype with vulnerability to aurora kinase inhibition new research holds promise for personalized lung cancer treatments elevated rheumatoid factor and long term risk of rheumatoid arthritis a prospective cohort study raised antibody levels linked to greater long term risk of rheumatoid arthritis a valent hpv vaccine against infection and intraepithelial neoplasia in women new hpv vaccine offers greater protection against cervical cancer than current vaccine a role for neuronal alpha synuclein in gastrointestinal immunity protein associated with parkinson s disease linked to human upper gi tract infections autologous hematopoetic stem cell transplantation for refractory crohn diseasea randomized clinical trial stem cell transplantation does not provide significant improvement for crohn s disease prenatal exposure to butylbenzyl phthalate and early eczema in an urban cohort prenatal exposure to common household chemical phthalate increases risk for childhood eczema pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus induced disease bacterial colonization prior to catching flu may protect against severe illness basophils trigger emphysema development in a murine model of copd through il mediated generation of mmp producing macrophages researchers breathe new life into copd research using mouse models decadal shifts in autumn migration timing by pacific arctic beluga whales are related to delayed annual sea ice formation arctic sea ice loss impacts beluga whale migration hiv evades innate immune recognition through specific cofactor recruitment discovery of hiv invisibility cloak reveals new treatment opportunities alanine scan of conotoxin regiia reveals a selective nicotinic acetylcholine receptor antagonist cone snail venom holds promise for medical treatments for cancer addiction a nucleic acid hydrolyzing single chain antibody confers resistance to dna virus infection in hela cells and c bl mice a mini antibody with broad antiviral activity chews up viral dna and rna impact of pre columbian geoglyph builders on amazonian forests hundreds of ancient earthworks built in the amazon recalibration of auditory space following milliseconds of cross modal discrepancy study of how brain corrects perceptual errors has implications for brain injuries robotics fallout melt debris and aerodynamically shaped glasses in beach sands of hiroshima bay japan glassy menagerie of particles in beach sands near hiroshima is fallout debris study concludes protein typing of circulating microvesicles allows real time monitoring of glioblastoma therapy detection analysis of cell dust may allow diagnosis monitoring of brain cancer first discovery of the charophycean green alga lychnothamnus barbatus charophyceae extant in the new world dinosaur era plant found alive in north america for first time chronic stress depressive symptoms anger hostility and risk of stroke and transient ischemic attack in the multi ethnic study of atherosclerosis high stress hostility depression linked with increased stroke risk antidepressants during pregnancy and autism in offspring population based cohort study antidepressant use in pregnancy linked to autism in children but risk is low addressable electron spin resonance using donors and donor molecules in silicon tuning into quantum scientists unlock signal frequency control of precision atom qubits magnifying smartphone screen using google glass for low vision users researchers develop magnifying smartphone screen app for visually impaired association of mortality with the death of a sibling in childhood does death of a sibling in childhood increase risk of death in surviving children ? nuclear translocation of fgfr and fgf in pancreatic stellate cells facilitates pancreatic cancer cell invasion embo molecular medicine unexpected cell hijack method in pancreatic cancer revealed by research size sorting on the rubble pile asteroid itokawa mechanism underlying size sorting of rubble on asteroid itokawa revealed the evolution of anti bat sensory illusions in moths anti bat signal moths with larger hindwings and longer tails are best at deflecting bats long term outcomes of exercise follow up of a randomized trial in older women with osteopenia exercise associated with lower rate of fractures in elderly women arid b haploinsufficiency disrupts cortical interneuron development and mouse behavior breakthrough research suggests potential treatment for autism intellectual disability persistent aberrant cortical phase amplitude coupling following seizure treatment in absence epilepsy models brain activity between seizures informs potential treatment for childhood absence epilepsy differences in management and outcomes for men and women with st elevation myocardial infarction women under treated for heart attacks die at twice the rate of men development of reduced kidney function in rheumatoid arthritis vigilance for kidney problems key for rheumatoid arthritis patients study finds breakdown of the stokes einstein relation above the melting temperature in a liquid phase change material a new light on significantly faster computer memory devices gene therapy restores balance and auditory functions in a mouse model of usher syndrome novel gene therapy experiment offers hope for people with certain hearing loss and dizziness disorder in utero exposure to selective serotonin reuptake inhibitors and risk for autism spectrum disorder in utero exposure to antidepressants may influence autism risk prenatal antidepressant exposure is associated with risk for attention deficit hyperactivity disorder but not autism spectrum disorder in a large health system link between prenatal antidepressant exposure autism risk called into question role of mitochondrial dynamics in neuronal development mechanism for wolfram syndrome mitochondrial dynamics impair nervous system development in wolfram syndrome exposure to mercury and aroclor congeners in least terns sternula antillarum in coastal georgia usa toxic chemical discovered in birds outside of superfund site the consistency of circadian blood pressure and heart rate patterns over three months in women employed in sedentary office jobs your blood pressure and heart rate change to meet physical and social demands seismic evidence for a crustal magma reservoir beneath the upper east rift zone of kilauea volcano hawaii large deep magma chamber discovered below kilauea volcano largely unknown internal plumbing of volcanoes grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis grape based compounds kill colon cancer stem cells in mice vitamin c restores healthy aging in a mouse model for werner syndrome vitamin c cures mice with accelerated aging disease global genetic analysis in mice unveils central role for cilia in congenital heart disease mutations associated with development of congenital heart disease autophagy enhances nf b activity in tissue dependent macrophages by sequestering a to boost anti fungal immunity cell s recycling team helps sound alarm on pathogens the establishment of resident memory b cells in the lung requires local antigen encounter memory b cells in the lung may be important for more effective influenza vaccinations structure and consistency of self reported social contact networks in british secondary schools new insights into school friendship patterns could boost research into infectious disease outbreaks emergence of functional subnetworks in layer cortex induced by sequential spikes in vivo new insights into functional organization of somatosensory cortex cardiovascular health in young adulthood and structural brain mri in midlife healthy heart in s for a healthy brain in s generation and visualization of emotional states in virtual characters virtual faces created with emotions moods and personality address level effects in aguadilla puerto rico from the mw. earthquake and tsunami forgotten archives reveal street level impact of puerto rico earthquake and tsunami imaging individual neurons in the retinal ganglion cell layer of the living eye a closer look at the eye new retinal imaging technique gender differences in loss of psychological resources following experimentally induced vicarious stress gender differences viewing tv coverage of terrorism has more negative effect on women study finds first harvest of p rigord black truffle in the uk as a result of climate change p rigord black truffle cultivated in the uk for the first time macroeconomic environment during infancy as a possible risk factor for adolescent behavioral problems economic environment during infancy linked with substance use delinquent behavior in adolescence lizards of the lost arcs mid cenozoic diversification persistence and ecological marginalization in the west pacific swaths of asia inhabited by surprisingly related lizards of the lost arcs impact of continued mailed fecal tests in the patient centered medical home year of the systems of support to increase colon cancer screening and follow up randomized trial lifesaving approach to screening for colon cancer steps forward vaginal exposure to zika virus during pregnancy leads to fetal brain infection in wild type mice new mouse model of zika sexual transmission shows spread to fetal brain three dimensional stimulation and imaging based functional optical microscopy of biological cells manipulating cell networks with light new frontiers in optical microscopy effects of tobacco smoke and electronic cigarette vapor exposure on the oral and gut microbiota in humans a pilot study vapers and non smokers have the same flourishing gut flora association of paid sick leave with job retention and financial burden among working patients with colorectal cancer less financial burden for cancer patients with paid sick leave study finds metformin and low levels of thyroid stimulating hormone in patients with type diabetes mellitus common diabetes drug associated with risk of low levels of thyroid hormone antibacterial effects of grape extracts on helicobacter pylori grape extracts may be effective against harmful gut bacteria modeled osteopathic manipulative treatments a review of their in vitro effects on fibroblast tissue preparations in vitro cellular response to osteopathic manipulative therapy provides proof of concept debris flows on the great kobuk sand dunes alaska implications for analogous processes on mars debris flows on arctic sand dunes are similar to dark dune spot seepage flows on mars gestational and postnatal cortisol profiles of women with posttraumatic stress disorder and the dissociative subtype pregnant women with ptsd have higher levels of stress hormone cortisol the hepatitis b virus ribonuclease h is sensitive to inhibitors of the human immunodeficiency virus ribonuclease h and integrase enzymes in a fight to the finish research aims knockout punch at hepatitis b aha asa focused update of the guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment a guideline for healthcare professionals from the american heart association american stroke association clot removal devices now recommended for some stroke patients contralateral mastectomy and survival after breast cancer in carriers of brca and brca mutations retrospective analysis double mastectomy halves death risk for women with brca related breast cancer fruit and vegetable consumption and all cause cancer and cvd mortality analysis of health survey for england data new evidence linking fruit and vegetable consumption with lower mortality prevalence of diagnosed type and type diabetes among us adults in and population based study current rates of diagnosed type and type diabetes in american adults heuristic aspect of the lateral root initiation index a case study of the role of nitric oxide in root branching the root of the matter the role of nitric oxide in root branching early art results in greater immune reconstitution benefits in hiv infected infants working with data missingness in a longitudinal dataset scientists overcome missing data to demonstrate art effectiveness in hiv infected infants host phylogeny constrains cross species emergence and establishments of rabies virus in bats how viruses jump from hosts secrets of rabies transmission in bats discovered generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells converting adult human cells to hair follicle generating stem cells development and characterization of a high quality plum tomato essence scientists work on the essence of better tasting tomato juice case control study of cutaneous human papillomaviruses in squamous cell carcinomas of the skin cutaneous human papillomavirus infection a risk factor for skin cancer toward a differential diagnosis of hidden hearing loss in humans evidence of hidden hearing loss in college age human subjects the ph of activation of the hemagglutinin protein regulates h n influenza virus replication and pathogenesis in mice mutation altering stability of surface molecule in acid enables h n infection of mammals oestrogen increases haematopoietic stem cell self renewal in females and during pregnancy scientists find estrogen promotes blood forming stem cell function energy spectrum of cosmic ray electron and positron from gev to tev observed with the calorimetric electron telescope on the international space station first direct measurements of high energy electrons in space previous violent events and mental health outcomes in guatemala strong connection between violence mental illness in guatemala during civil war lessens in postwar period visualizing cellular interactions with a generalized proximity reporter new technique to track cell interactions in living bodies developed recycled iron fuels new production in the eastern equatorial pacific ocean mystery of phytoplankton survival in nutrient poor pacific process outcomes in breast reconstruction and the impact of a comprehensive breast center comprehensive breast center improves quality of care for breast reconstruction prevalence and risk factors of dry eye disease in a british female cohort around in uk women has dry eye disease requiring artificial tears spatial distribution of prokaryotic communities in hypersaline soils microscopic life in the saline soil of the marismas del odiel natural park sympathetic fiber sprouting in inflamed joints and adjacent skin contributes to pain related behavior in arthritis study points to role of nervous system in arthritis video evidence and other information relevant to the conservation of the ivory billed woodpecker campephilus principalis conservation of ivory billed woodpecker s habitat urged the sharing economy how sharing activities influence value creation in the tv audience market audience members influence value creation in the tv audience market diagnostic accuracy of ophthalmoscopy vs telemedicine in examinations for retinopathy of prematurity telemedicine provides accurate diagnosis of rare cause of blindness in preemies racial ethnic disparities in knowledge about one s breast cancer characteristics many women with breast cancer have poor knowledge about their condition production of monoclonal antibodies to pathologic sheet oligomeric conformers in neurodegenerative diseases new antibodies target protein structures common to several neurological diseases association of adipose tissue fatty acids with cardiovascular and all cause mortality in elderly men polyunsaturated fat in adipose tissue linked to lower mortality an atlas of over conserved noncoding sequences provides insight into crucifer regulatory regions genomic atlas of gene switches in plants provides roadmap for crop research lack of kinase independent activity of pi k in locus coeruleus induces adhd symptoms through increased creb signaling novel mechanism involved in attention deficit hyperactivity disorder study shows antigenic subversion a novel mechanism of host immune evasion by ebola virus ebola virus uses a protein decoy to subvert the host immune response time series analysis of fine particulate matter and asthma reliever dispensations in populations affected by forest fires measuring the consequence of forest fires on public health ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle aged rats new treatment for dementia discovered deep brain stimulation real time monitoring of metabolic function in liver on chip microdevices tracks the dynamics of mitochondrial dysfunction new human on chip technology permits unparalleled insight into cellular function dynamics single delivery of high diversity fecal microbiota preparation by colonoscopy is safe and effective in increasing microbial diversity in active ulcerative colitis fecal microbiota transplant is safe and effective for patients with ulcerative colitis diagnostic accuracy of laxative free computed tomographic colonography for detection of adenomatous polyps in asymptomatic adults a prospective evaluation virtual colonoscopy without laxative equals standard oc in identifying clinically significant polyps evaluating recovery potential of the northern white rhinoceros from cryobanked cells imminent extinction of northern white rhinoceros motivates genetic recovery efforts genetic polymorphisms modify bladder cancer recurrence and survival in a usa population based prognostic study certain genetic variants may put bladder cancer patients at increased risk of recurrence crtc activates a transcriptional program deregulated at early alzheimer s disease related stages loss of memory in alzheimer s mice models reversed through gene therapy effect of prolonged sitting and breaks in sitting time on endothelial function taking short walking breaks found to reverse negative effects of prolonged sitting dietary fiber confers protection against flu by shaping ly c patrolling monocyte hematopoiesis and cd t cell metabolism a high fiber diet protects mice against the flu virus assessing the safety of superficial chemical peels in darker skin a retrospective study chemical peels are safe for people with darker skin result in few side effects and complications novel picornavirus associated with avian keratin disorder in alaskan birds newly discovered virus a prime suspect in often fatal beak disorder spreading among birds genetic outcomes of translocation of bighorn sheep in arizona translocation of bighorn sheep in arizona has positive genetic outcomes methane and dissolved organic carbon fueled microbial loop supports a tropical subterranean estuary ecosystem mexico s yucatan peninsula reveals a cryptic methane fueled ecosystem in flooded caves the human visual cortex response to melanopsin directed stimulation is accompanied by a distinct perceptual experience uncomfortable sight from an ancient reflex of the eye risk of venous thromboembolism in patients with rheumatoid arthritis and association with disease duration and hospitalizationvenous thromboembolism in rheumatoid arthritis patients with rheumatoid arthritis appear to be at increased risk for blood clots psychopathic sexuality the thin line between fantasy and reality a thin line lies between fantasy and reality in people with psychopathic traits pausing guides rna folding to populate transiently stable rna structures for riboswitch based transcription regulation pause to read the traffic sign regulation of dna transcription in bacteria immunohistochemical validation of psma expression measured by ga psma pet ct in primary prostate cancer psma pet ct clearly differentiates prostate cancer from benign tissue bves regulates emt in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma protein bves identified as a suppressor of colorectal cancer progression missed opportunities for hpv vaccination in adolescent girls a qualitative study provider parental assumptions on teen sex yield missed opportunities for hpv vaccine fatty acids regulate endothelial lipase and inflammatory markers in macrophages and in mouse aorta a role for ppar new link between high fat western diet and atherosclerosis identified the cholesterol metabolite hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha new driver of atherosclerosis offers potential as therapeutic target appetite and weight gain suppression effects of alcohol depend on the route and pattern of administration in long evans rats study in rats finds low blood alcohol levels have no effect on total calories consumed horizontal transfer of entire genomes via mitochondrial fusion in the angiosperm amborella driving force behind mitochondrial sex in ancient flowering plant a common variant in mir is associated with primary open angle glaucoma in the neighborhood consortium high expression of short gene appears to contribute to destructive eye pressures in glaucoma baseline gray and white matter volume predict successful weight loss in the elderly brain volume predicts successful weight loss in the elderly structural decline in china s co emissions through transitions in industry and energy systems china s emissions reversal cause for cautious optimism says study lung endothelial monocyte activating protein is a mediator of cigarette smoke induced emphysema in mice protein could offer target to reduce lung damage from smoking caused emphysema hiv uses dynamic capsid pores to import nucleotides and fuel encapsidated dna synthesis discovery of key component of hiv yields new drug target the millidelta a high bandwidth high precision millimeter scale delta robot small but fast a miniaturized origami inspired robot combines micrometer precision with high speed gloria knolls slide a prominent submarine landslide complex on the great barrier reef margin of north eastern australia largest undersea landslide revealed on the great barrier reef the negative impact of anemia in outcome from traumatic brain injury anemia negatively affects recovery from traumatic brain injuries tectonic control of yarlung tsangpo gorge revealed by a buried canyon in southern tibet geologists discover ancient buried canyon in south tibet awareness of breast density and its impact on breast cancer detection and risk u.s. women s awareness of breast density varies by race ethnicity education and income functional reduction in pollination through herbivore induced pollinator limitation and its potential in mutualist communities reductions in individual plant growth sometimes boost community resilience implementation and effectiveness of an online responsible vendor training program for recreational marijuana stores in colorado oregon and washington state the effectiveness of online cannabis responsible vendor training program efficacy of hpv as adjuvanted vaccine against cervical infection and precancer in young women final event driven analysis of the randomised double blind patricia trial hpv vaccine highly effective against multiple cancer causing strains on the scent of an animal skin new evidence on corded ware mortuary practices in northern europe domestic goat dating back to the neolithic corded ware period identified in finland comparison of bryan cervical disc arthroplasty with anterior cervical decompression and fusion clinical and radiographic results of a randomized controlled clinical trial artificial disc replacement as good or better than spinal fusion surgery study suggests a new species and the shallowest record of flabegraviera salazar vallejo annelida flabelligeridae from antarctica new species of marine worm discovered in antarctica exclusive breastfeeding and cognition executive function and behavioural disorders in primary school aged children in rural south africa a cohort analysis new evidence links exclusive breastfeeding early play stimulation to children s later success antiplatelet therapy duration following bare metal or drug eluting coronary stents duration of antiplatelet therapy following pci risk of adverse events patient safety perceptions in pediatric out of hospital emergency care children s safety initiative pediatric training essential to improving out of hospital emergency care for children trajectories of health related quality of life by socio economic status in a nationally representative canadian cohort lifelong gap in health between rich and poor set by age canadian study finds a pan european multipopulation assessment of migratory connectivity in a near threatened migrant bird uncovered european roller s route between africa europe acute myocardial infarction after laboratory confirmed influenza infection link between flu and heart attack confirmed in new research interactions of fungi with concrete significant importance for bio based self healing concrete self healing fungi concrete could provide sustainable solution to crumbling infrastructure functionally distinct subsets of lineage biased multipotent progenitors control blood production in normal and regenerative conditions scientists identify progenitor cells for blood immune system the apple of the mind s eye everyday attention metamemory and reconstructive memory for the apple logo apple of the mind s eye how good is our memory of everyday visual stimuli ? surrogate headform accelerations associated with stick checks in girls lacrosse whack ! study measures head blows in girls lacrosse clinical features and serum biomarkers in hiv immune reconstitution inflammatory syndrome after cryptococcal meningitis a prospective cohort study biomarkers could predict death in aids patients with severe inflammation cost effectiveness of approaches to managing nasolacrimal duct obstruction in infants the importance of the spontaneous resolution rate study evaluates cost effectiveness of strategies to treat infant tear duct obstruction palynological analyses of eocene to oligocene sediments from dsdp site outer v ring plateau from greenhouse to icehouse reconstructing the environment of the voring plateau ce original research an investigation into the safety of oral intake during labor ice chips only ? study questions restrictions on oral intake for women in labor preterm birth and risk of chronic kidney disease from childhood into mid adulthood national cohort study premature birth linked to increased risk of chronic kidney disease into later life coincident light and clock regulation of pseudoresponse regulator protein prr controls photoperiodic flowering in sorghum gene controlling flowering boosts energy production from sorghum accuracy of the atherosclerotic cardiovascular risk equation in a large contemporary multiethnic population cardiovascular risk tool overestimates actual chance of cardiovascular events clpb variants associated with autosomal recessive mitochondrial disorder with cataract neutropenia epilepsy and methylglutaconic aciduria discovery of clpb gene associated with a new pediatric mitochondrial syndrome mutational landscape of secondary glioblastoma guides met targeted trial in brain tumor scientists bring new hope to brain tumor patients the number of genomic copies at the p. locus modulates language verbal memory and inhibition genomic region associated with autism plays role in specific cognitive functions gut flora metabolism of phosphatidylcholine promotes cardiovascular disease common dietary fat and intestinal microbes linked to heart disease converging high level coupled cluster energetics by monte carlo sampling and moment expansions quantum leap computational approach launches new paradigm in electronic structure theory seasonal evaluation of tropospheric co over the asia pacific region observed by the contrail commercial airliner measurements commercial airliners reveal three dimensional distribution of atmospheric co over asia pacific association between low density lipoprotein cholesterol lowering genetic variants and risk of type diabetes certain ldl c lowering genetic variants associated with higher risk of type diabetes exercise conditioning in old mice improves skeletal muscle regeneration exercise may have therapeutic potential for expediting muscle repair in older populations cd downregulation of placental macrophage trophoblastic interactions in preeclampsia inflammation of the placenta interferes with fetal development novel ecological and climatic conditions drive rapid adaptation in invasive florida burmese pythons genomic evidence of rapid adaptation of invasive burmese pythons in florida raads screen validity of a screening tool for autism spectrum disorder in an adult psychiatric population new test facilitates diagnosis of autism in adults potential hazards of adding nonsteroidal anti inflammatory drugs to antithrombotic therapy after myocardial infarction taking nsaids with anti clotting medications risk of bleeding cv events increased breast cancer risk for patients with multiple sclerosis a nationwide population based cohort study patients with ms may be at increased risk of developing cancer a marker of adhd behavior and motor development in children abnormal control of hand movements may hint at adhd severity in children hypericum perforatum st john s wort for attention deficit hyperactivity disorder in children and adolescents a randomized controlled trial st. john s wort does not appear effective for treating adhd in children and teens the interplay of multiple feedback loops with post translational kinetics results in bistability of mycobacterial stress response possible persistence switch for tuberculosis found computer model finds probable genetic mechanism for tb dormancy acid sensitive channel inhibition prevents fetal alcohol spectrum disorders cerebellar purkinje cell loss damage to fetal brain blocked following maternal alcohol consumption bounce fabric softener dryer sheets repel fungus gnat bradysia sp. nr. coprophila diptera sciaridae adults fabric softener sheets repel gnats scientists prove bounce sheets fend off insect pests occurrence of demersal fishes in relation to near bottom oxygen levels within the california current large marine ecosystem low oxygen impacts on west coast groundfish research shows austerity measles and mandatory vaccination cross regional analysis of vaccination in italy healthcare cuts strongly linked to the resurgence of measles in italy outcomes in patients undergoing primary percutaneous coronary intervention for st segment elevation myocardial infarction via radial access anticoagulated with bivalirudin versus heparin no difference in rate of adverse cardiovascular events when comparing anticoagulants surface water dependent properties of sulfur rich molybdenum sulfides electrolyteless gas phase water splitting solar paint offers endless energy from water vapor mindfulness based cancer recovery and supportive expressive therapy maintain telomere length relative to controls in distressed breast cancer survivors meditation support groups clear new evidence for mind body connection demonstrated in study researchers show have gender gaps in math closed ? achievement teacher perceptions and learning behaviors across two ecls k cohorts gender gaps in math persist with teachers underrating girls math skills prognostic value of noninvasive cardiovascular testing in patients with stable chest painclinical perspective ct angiography appears better at predicting future risk for patients with chest pain chronic obstructive pulmonary disease and sudden cardiac death the rotterdam study chronic obstructive pulmonary disease increases the risk of sudden cardiac death low fertility increases descendant socioeconomic position but reduces long term fitness in a modern post industrial society small family size increases wealth of descendants but reduces evolutionary success the role of mitochondrially derived atp in synaptic vesicle recycling loss of cellular energy leads to neuronal dysfunction in neurodegenerative disease model neurotoxic effects of anthracycline vs nonanthracycline based chemotherapy on cognition in breast cancer survivors neurotoxic effects of chemotherapies on cognition in breast cancer survivors ebola virus disease clinical care and patient centred research basic medical care of ebola patients neglected and must improve robust asymmetric synthesis of unnatural alkenyl amino acids for conformationally constrained helix peptides new designer proteins in fight against alzheimer s cancer super aggregations of krill and humpback whales in wilhelmina bay antarctic peninsula record number of whales krill found in antarctic bays coevolution of visual behaviour the material world and social complexity depicted by the eye tracking of archaeological objects in humans proofs of parallel evolution between cognition tool development and social complexity saa is a key mediator of the protumorigenic properties of cancer associated fibroblasts in pancreatic tumors researchers discover a potential new therapeutic strategy for pancreatic cancer geoengineer polar glaciers to slow sea level rise geoengineering polar glaciers to slow sea level rise focal resection of fast ripples on extraoperative intracranial eeg improves seizure outcome in pediatric epilepsy fast ripples confirmed to be valuable biomarker of area responsible for seizure activity in children readaptation of the vestibulo ocular reflex relieves the mal de debarquement syndrome new treatment successful for rare disabling movement disorder the mal de debarquement syndrome mdds trastuzumab plus adjuvant chemotherapy for human epidermal growth factor receptor positive breast cancer planned joint analysis of overall survival from nsabp b and ncctg n years after treatment for her positve early stage breast cancer trastuzumab continues to show life altering benefit withering syndrome susceptibility of northeastern pacific abalones a complex relationship with phylogeny and thermal experience study of mollusk epidemic could help save endangered sea snail an environment wide association study ewas on type diabetes mellitus new associations between diabetes environmental factors found by novel analytic technique pre morbid body mass index and mortality after incident heart failure survival rates higher in obese heart failure patients potential role of viruses in white plague coral disease viruses associated with coral epidemic of white plague mek inhibitors activate wnt signalling and induce stem cell plasticity in colorectal cancer cancer drugs promote stem cell properties of colorectal cancer transcriptomic analysis reveals protein homeostasis breakdown in the coral acropora millepora during hypo saline stress reduced salinity of seawater wreaks havoc on coral chemistry breast milk feeding brain development and neurocognitive outcomes a year longitudinal study in infants born at less than weeks gestation breastfeeding associated with better brain development neurocognitive outcomes hormone therapy in transgender adults is safe with provider supervision a review of hormone therapy sequelae for transgender individuals hormone therapy in transgender adults safe study shows triple negative breast cancers with amplification of jak at the p locus demonstrate jak specific dependence study finds explanation for some treatment resistant breast cancers a tissue engineered blood vessel model of hutchinson gilford progeria syndrome using human ipsc derived smooth muscle cells artificial blood vessels mimic rare accelerated aging disease intensive surveillance with bi annual dynamic contrast enhanced magnetic resonance imaging downstages breast cancer in brca mutation carriers for women with genetic risk semi annual mri beats mammograms cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype oncology genetic variability in a tumor as an indicator of patient risk trends in u.s. cardiovascular care report from acc national cardiovascular data registries report highlights national trends in heart disease treatments motion of heavy particles on a submerged chladni plate a surprising experiment opens the path to new particle manipulation methods bortezomib for treatment of therapy refractory anti nmda receptor encephalitis new treatment for a rare form of encephalitis role of t cell reconstitution in hiv antiretroviral therapy induced bone loss zolodrenic acid can prevent early bone loss in hiv patients on antiretroviral therapy dietary omega fatty acid and fish intake and incident age related macular degeneration in women omega fatty acid intake linked with reduced risk of age related macular degeneration in women lifetime substance use as a predictor of postpartum mental health drug use strong predictor for postpartum mental health problems high quality monolayer graphene synthesized by resistive heating cold wall chemical vapor deposition breakthrough graphene production could trigger revolution in artificial skin development huntingtin promotes mtorc signaling in the pathogenesis of huntington s disease major factor in development of huntington s disease uncovered impact and lessons learned from mass drug administrations of malaria chemoprevention during the ebola outbreak in monrovia liberia liberian malaria cases declined following mass drug administration during ebola outbreak relationships between indicators of cardiovascular disease and intensity of oil and natural gas activity in northeastern colorado possible connection between cardiovascular disease and living near oil and gas wells ferumoxytol as an intravenous iron replacement therapy in hemodialysis patients new form of intravenous iron treats anemia in chronic kidney disease patients on dialysis highly reactive free radicals in electronic cigarette aerosols potentially dangerous molecules detected in e cigarette aerosols sex and age differences in the association of depression with obstructive coronary artery disease and adverse cardiovascular events depression linked to higher heart disease death risk in younger women evolution of amplitude integrated electroencephalogram as a predictor of outcome in term encephalopathic neonates receiving therapeutic hypothermia continuous eeg better at identifying oxygen deprived newborns most at risk fmri reveals reciprocal inhibition between social and physical cognitive domains empathy represses analytic thought and vice versa brain physiology limits simultaneous use of both networks large amplitude internal waves benefit corals during thermal stress cool deep water protects coral reefs against heat stress reprogramming suppresses premature senescence phenotypes of werner syndrome cells and maintains chromosomal stability over long term culture establishment of induced pluripotent stem cells from werner syndrome fibroblasts medicinal value of sunflower pollen against bee pathogens sunflower pollen has medicinal protective effects on bees a prospective study of physical activity and fecundability in women with a history of pregnancy loss for women with history of pregnancy loss walking may aid chance of becoming pregnant the treatment naive microbiome in new onset crohn s disease large study identifies exact gut bacteria involved in crohn s disease three new species of eriophyoid mites acari eriophyoidea from xinjiang uygur autonomous region china the mite and the rose non threatening new mite species found in xinjiang china restoring natural sensory feedback in real time bidirectional hand prostheses amputee feels in real time with bionic hand multiscale simulation reveals a multifaceted mechanism of proton permeation through the influenza a m proton channel computation leads to better understanding of influenza virus replication mitochondrial pyruvate carrier regulates autophagy inflammation and neurodegeneration in experimental models of parkinson s disease diabetes drug slows experimental parkinson s disease progression human trials to begin next year atrioventricular accessory pathways in dogs clinical features and outcome after radiofrequency catheter ablation new method to treat life threatening heart arrhythmias in dogs dynamics of salmonella shedding and welfare of hens in free range egg production systems hot weather not to blame for salmonella on egg farms bcl a enhancer dissection by cas mediated in situ saturating mutagenesis gene editing study reveals possible achilles heel of sickle cell disease a simple sarcopenia screening test predicts future adverse events in patients with heart failure simple screening test can predict heart failure severity multicomponent mhealth intervention for large sustained change in multiple diet and activity risk behaviors the make better choices randomized controlled trial bad habits that lead to cancer chronic disease corrected by simple lifestyle intervention single cell developmental classification of b cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse renegade cells portend relapse in children with leukemia gingipains from the periodontal pathogen porphyromonas gingivalis play a significant role in regulation of angiopoietin and angiopoietin in human aortic smooth muscle cells periodontitis and heart disease researchers connect the molecular dots serotonergic neurons respond to nutrients and regulate the timing of steroid hormone biosynthesis in drosophila caterpillar to butterfly new light shed on diet steroid hormones and development a continental scale hydroeconomic model for integrating water energy land nexus solutions innovative tool allows continental scale water energy and land system modeling hydralazine induces stress resistance and extends c. elegans lifespan by activating the nrf skn signalling pathway fda approved high blood pressure drug extends life span in roundworms the legacy of the pleistocene megafauna extinctions on nutrient availability in amazonia extinctions of large animals sever the earth s nutrient arteries enhancing gardens as habitats for flower visiting aerial insects pollinators should we plant native or exotic species ? native plants alone may not be the best option for pollinating insects in uk gardens dynamics of a morbillivirus at the domestic wildlife interface canine distemper virus in domestic dogs and lions dog disease in lions spread by multiple species soy based infant formula feeding and menstrual pain in a cohort of women aged years soy formula feeding during infancy associated with severe menstrual pain in adulthood fast food consumption and academic growth in late childhood fast food consumption linked to lower test score gains in th graders dementia risk after traumatic brain injury vs nonbrain trauma traumatic brain injury associated with increased dementia risk in older adults enhancement of astatine uptake via the sodium iodide symporter by the addition of ascorbic acid in targeted alpha therapy of thyroid cancer breakthrough alpha ray treatment of cancer without external radiation moderate drinking ? alcohol consumption significantly decreases neurogenesis in the adult hippocampus moderate drinking decreases number of new brain cells the association of anger and hostility with future coronary heart disease a meta analytic review of prospective evidence anger and hostility harmful to the heart especially among men drugs for treating severe hypertension in pregnancy a network meta analysis and trial sequential analysis of randomized clinical trials drugs for treating severe hypertension in pregnancy compared reversal of maladaptive fibrosis and compromised ventricular function in the pressure overloaded heart by a caveolin surrogate peptide peptide reverses cardiac fibrosis in a preclinical model of congestive heart failure disparities in transition planning for youth with autism spectrum disorder youths with autism spectrum disorder need help transitioning to adult health care the dispersion brightness relation for fast radio bursts from a wide field survey new telescope almost doubles known number of mysterious fast radio bursts targeting p increases dna damage chromosome instability and the anti tumoral response to taxanes in breast cancer cells tumor cells evade death through in extremis dna repair fabrication with semiconductor packaging technologies and characterization of a large scale flexible thermoelectric module flexible thermoelectric generator module a silver bullet to fix waste energy issues a mass sacrifice of children and camelids at the huanchaquito las llamas site moche valley peru hundreds of children and llamas sacrificed in a ritual event in th century peru an integrated genomics approach identifies drivers of proliferation in luminal subtype human breast cancer new approach to identify drivers of cancer developed complementary alternative medicine for children with autism a physician survey medical care for children with autism using complementary alternative medicine detecting crop population growth using chlorophyll fluorescence imaging innovative system images photosynthesis to provide picture of plant health menadione induced dna damage leads to mitochondrial dysfunction and fragmentation during rosette formation in fuchs endothelial corneal dystrophy new research links mitochondrial dysfunction to the development of fuchs endothelial corneal dystrophy fabrication and properties of microencapsulated paraffin sio phase change composite for thermal energy storage paraffin encapsulated in beach sand material as a new way to store heat from the sun cell and protein compatible d bioprinting of mechanically strong constructs for bone repair bioprinted play dough capable of cell and protein transfer a supramolecular approach to the preparation of nanographene adlayers using water soluble molecular capsules molecular adlayer produced by dissolving water insoluble nanographene in water small molecule inhibitors reveal niemann pick c is essential for ebola virus infection researchers identify protein essential in transmission of ebola virus perceptions of statin discontinuation among patients with life limiting illness patients nearing end of life receptive to having cholesterol medicine deprescribed ankle brachial index but neither intima media thickness nor coronary artery calcification is associated with mild cognitive impairment ankle brachial index associated with mild cognitive impairment single degree of freedom everting ring linkages with nonorientable topology m bius kaleidocycles sensational structures with potential applications repeated low dose intradermal allergen injection suppresses allergen induced cutaneous late responses hayfever vaccine study raises hopes for new allergy treatment as clinical trial is launched safety and efficacy of early thromboembolism chemoprophylaxis after intracranial hemorrhage from traumatic brain injury new treatment effective at reducing blood clots in brain injured patients lactobacillus rhamnosus gg supplemented formula expands butyrate producing bacterial strains in food allergic infants probiotic formula reverses cow s milk allergies by changing gut bacteria of infants direct archaeological evidence for southwestern amazonia as an early plant domestication and food production centre archeological plant remains point to southwest amazonia as crop domestication center effect of propranolol on word fluency in autism promising drug treatment for improving language social function in people with autism observation of mean path length invariance in light scattering media the path length of light in opaque media what is the optimal level of population alcohol consumption for chronic disease prevention in england ? modelling the impact of changes in average consumption levels statistical model attempting to estimate level of alcohol consumption that is optimal for health the fe s cluster of human dna primase functions as a redox switch using dna charge transport electrons use dna like a wire for signaling dna replication the vital study and overall pooled analysis with the vips non invasive stroke detection device portable device detects severe stroke in seconds with percent accuracy do pluripotent stem cells exist in adult mice as very small embryonic stem cells ? scientists unable to find evidence of embryonic like cells in marrow of adult mice millennial scale fluctuations in saharan dust supply across the decline of the african humid period dust deposits give new insights into the history of the sahara selective serotonin reuptake inhibitors and the risk of osseointegrated implant failure a cohort study widely used depression drug associated with dental implant failure long lived epigenetic interactions between perinatal pbde exposure and mecp mutation common flame retardant linked to social behavioral and learning deficits cytokine signature associated with disease severity in chronic fatigue syndrome patients chronic fatigue syndrome biomarkers linked to severity identified maternal smoking during pregnancy and offspring conduct problems evidence from independent genetically sensitive research designs maternal smoking during pregnancy associated with offspring conduct problems study suggests randomized trial of a telephone based weight loss intervention in postmenopausal women with breast cancer receiving letrozole the lisa trial telephone call is effective support when breast cancer treatment includes weight loss expansion of commensal fungus wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice gut fungus exacerbates asthma in antibiotic treated mice bicycle riding walking and weight gain in premenopausal women bicycling brisk walking help women control weight researchers call for more bike friendly environments to combat obesity a single dose respiratory recombinant adenovirus based vaccine provides long term protection for non human primates from lethal ebola infection single dose needle free ebola vaccine provides long term protection in macaques comparative effectiveness of high dose versus standard dose influenza vaccination in community dwelling veterans studies yield mixed findings on high dose flu vaccine for elders clinical pathologic study of depressive symptoms and cognitive decline in old age depression as a risk factor for dementia link is independent of dementia related brain changes timing and rates of holocene normal faulting along the black mountains fault zone death valley usa death valley study helps determine evolution of western us landscapes protective efficacy of adenovirus protein vaccines against siv challenges in rhesus monkeys novel hiv vaccine regimen provides robust protection in non human primates use of a virtual reality physical ride on sailing simulator as a rehabilitation tool for recreational sports and community reintegration virtual sailing simulator shows key role of recreation in spinal cord injury rehabilitation effect of analytical treatment interruption and reinitiation of antiretroviral therapy on hiv reservoirs and immunologic parameters in infected individuals study supports use of short term hiv treatment interruption in clinical trials establishing a link between attention deficit disorder attention deficit hyperactivity disorder and childhood physical abuse thirty percent of adults with attention deficit disorder report childhood physical abuse paleobiology of sabretooth cat smilodon populator in the pampean region buenos aires province argentina around the last glacial maximum insights from carbon and nitrogen stable isotopes in bone collagen saber toothed cats hunted on the south american plains impaired recognition of basic emotions from facial expressions in young people with autism spectrum disorder assessing the importance of expression intensity children with autism find understanding facial expressions difficult but make similar mistakes as peers new study finds nrf activation by antioxidant antidiabetic agents accelerates tumor metastasis antioxidants in antidiabetic drugs may fuel cancer spread mouse study shows the frequency and extent of sub ice phytoplankton blooms in the arctic ocean solving the mystery of the arctic s green ice deciphering the tsunami wave impact and associated connection forces in open girder coastal bridges paradigm shift needed for designing tsunami resistant bridges onset patterns prior to months in autism spectrum disorders new insights into the implications of autism onset patterns differentiation of cd t cells into effector cells is enhanced by physiological range hyperthermia elevated body temperature helps certain types of immune cells to work better evidence suggests chronic obstructive pulmonary disease missed diagnosis versus misdiagnosis new chronic lung disease guidelines over diagnose older men and under diagnose younger women a multi model assessment of food security implications of climate change mitigation weighing up trade offs between food security and climate mitigation regulation of injury induced ovarian regeneration by activation of oogonial stem cells ovary regeneration in salamanders could provide solutions to human infertility a transgenic male only strain of the new world screwworm for an improved control program using the sterile insect technique it s a boy controlling pest populations with modified males the commensal microbiome is associated with anti pd efficacy in metastatic melanoma patients specific microbes in digestive tract can boost success for cancer immunotherapy a new sail backed styracosternan dinosauria ornithopoda from the early cretaceous of morella spain new species of sail backed dinosaur found in spain dna demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts viral infection in colon cancer stem cells mimicked druggable target identified predictable convergence in hemoglobin function has unpredictable molecular underpinnings new evolutionary finding species take different genetic paths to reach same trait the effect of airflow on thermographically determined temperature of the distal forelimb of the horse blowing in the wind how accurate is thermography of horses legs ? selective spider toxins reveal a role for the nav. channel in mechanical pain spiders put the bite on irritable bowel syndrome pain manipulating stored phonological input during verbal working memory researchers discovery of new verbal working memory architecture has implications for artificial intelligence effect of stratified care for low back pain in family practice impact back a prospective population based sequential comparison targeted treatment of back pain leads to drop in work absence genome wide identification of structure forming repeats as principal sites of fork collapse upon atr inhibition analysis reveals genomic effects of a new cancer treatment now in clinical trials more than poverty disruptive events among women having abortions in the usa distressing life events and poverty behind many abortions in u.s. study finds potential role of orexin and sleep modulation in the pathogenesis of alzheimer s disease protein that rouses brain from sleep may be target for alzheimer s prevention associations between urban sprawl and life expectancy in the united states impact of urban sprawl on life expectancy innovation hubs the. resolution cryo em structure of zika virus zika virus structure revealed a critical advance in the development of treatments recent changes in phytoplankton communities associated with rapid regional climate change along the western antarctic peninsula climate related changes affect life on the antarctic peninsula long term treatment with low dose caffeine worsens bpsd like profile in xtg ad mice model of alzheimer s disease and affects mice with normal aging long term caffeine worsens anxiety symptoms and fear of the new associated with alzheimer s disease stable isotopes reveal diet shift from pre extinction to reintroduced przewalski s horses reintroduced przewalski s horses have a different diet conductive composite materials fabricated from microbially produced protein nanowires scientists make new green electronic polymer based films with protein nanowires influence of menstrual cycle phase on neural and craving responses to appetitive smoking cues in naturally cycling females female smokers more likely to kick the habit by timing their quit date with their menstrual cycle study shows astrocyte specific deletion of sox promotes functional recovery after traumatic brain injury deletion of a stem cell factor promotes traumatic brain injury recovery in mice the effects of weirs on structural stream habitat and biological communities aquatic species decline at dams and weirs documented microbial fermentation of flaxseed fibers modulates the transcriptome of gpr expressing enteroendocrine cells and protects mice against diet induced obesity flaxseed fiber ferments in gut to improve health reduce obesity transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self tolerance coaxing ips cells to become more specialized prior to transplantation cuts rejection risk maternal inflammation disrupts fetal neurodevelopment via increased placental output of serotonin to the fetal brain maternal inflammation boosts serotonin impairs fetal brain development in mice transoceanic dispersal and plate tectonics shaped global cockroach distributions evidence from mitochondrial phylogenomics cockroach ancient geographic and genomic history traced back to last supercontinent detection of protein aggregates in brain and cerebrospinal fluid derived from multiple sclerosis patients multiple sclerosis first evidence of a rogue protein telomerase immortalization of human corneal endothelial cells yields functional hexagonal monolayers development of new corneal cell line provides powerful tool neural mechanisms supporting maladaptive food choices in anorexia nervosa key differences in brain activity in people with anorexia nervosa revealed by study high energy breakfast with low energy dinner decreases overall daily hyperglycaemia in type diabetic patients a randomised clinical trial high energy breakfast with low energy dinner helps control blood sugar in people with type diabetes feasibility of lung cancer prediction from low dose ct scan and smoking factors using causal models artificial intelligence cuts lung cancer screening false positives effect of wearable technology combined with a lifestyle intervention on long term weight lossthe idea randomized clinical trial activity trackers are ineffective at sustaining weight loss effects of child development accounts on early social emotional development child savings accounts promote positive social emotional development study finds stretchable transparent ultrasensitive and patchable strain sensor for human machine interfaces comprising a nanohybrid of carbon nanotubes and conductive elastomers making robots more human wearable sensors read human facial expressions an n heterocyclic carbene based silver precursor for plasma enhanced spatial atomic layer deposition of silver thin films at atmospheric pressure ultra thin transparent silver films for solar cells host manipulation by an ichneumonid spider ectoparasitoid that takes advantage of preprogrammed web building behaviour for its cocoon protection parasitized spider makes bed for its natural enemy wasp larva microrna is required for t cell and b cell pathogenicity in chronic graft versus host disease in mice uncovering a mechanism causing chronic graft vs host disease after bone marrow transplant the std activator of the snf ampk kinase controls glucose response in yeast by a regulated protein aggregation from the omelette to the egg reversing protein aggregations human resources estimates and funding for antibiotic stewardship teams are urgently needed antibiotic stewardship teams must be planned and paid for to halt dangerous infections ancient mitogenomes of phoenicians from sardinia and lebanon a story of settlement integration and female mobility ancient phoenician dna from sardinia lebanon reflects settlement integration mobility interleukin combined with art reduces inflammation and viral reservoir in siv infected macaques il repairs immune function in primate model of hiv infection marching into battle synchronized walking diminishes the conceptualized formidability of an antagonist in men marching in unison may increase risk of use of excessive force in policing protests the incidence of brain metastases in stage iv ros rearranged non small cell lung cancer and rate of central nervous system progression on crizotinib brain metastases common and difficult to treat in ros lung cancer sleep neurophysiological dynamics through the lens of multitaper spectral analysis advanced eeg analysis reveals the complex beauty of the sleeping brain association of repeated intravitreous bevacizumab injections with risk for glaucoma surgery repeated eye injections for age related macular degeneration associated with increased risk for glaucoma diet quality indices and risk of type diabetes mellitus quality of overall diet is key to lowering type diabetes risk simultaneous inhibition of cell cycle proliferation survival metastatic pathways and induction of apoptosis in breast cancer cells by a phytochemical super cocktail genes that underpin its mode of action research finds combo of plant nutrients kills breast cancer cells maternal midpregnancy glucose levels and risk of congenital heart disease in offspring elevated blood sugar levels in pregnancy tied to baby s heart defect risk supersonic gas streams enhance the formation of massive black holes in the early universe supersonic gas streams left over from the big bang drive massive black hole formation collapse of amphibian communities due to an introduced ranavirus amphibian communities collapse in wake of viral outbreak melanoma cells break down lpa to establish local gradients that drive chemotactic dispersal molecular breadcrumb trail that helps melanoma spread found mountain climbing bears protect cherry species from global warming through vertical seed dispersal can mountain climbing bears rescue cherry trees from global warming ? meshworm a peristaltic soft robot with antagonistic nickel titanium coil actuators soft autonomous robot inches along like an earthworm flexible design enables body morphing capability low birth weight and respiratory disease in adulthood a population based case control study low birth weight linked to long term respiratory problems high risk alcohol use after weight loss surgery more than half of high risk alcohol users report improvement after surgery chimpanzee genomic diversity reveals ancient admixture with bonobos genome sequencing reveals ancient interbreeding between chimpanzees and bonobos the polyploid state plays a tumor suppressive role in the liver liver cells with whole genome duplications protect against cancer study shows enhancing cognitive and social emotional development through a simple to administer mindfulness based school program for elementary school children a randomized controlled trial. mindfulness based program in schools making a positive impact study shows visual tuning in the flashlight fish anomalops katoptron to detect blue bioluminescent light light receptors determine the behavior of flashlight fish important role of menarche in development of estrogen receptor negative breast cancer in african american women early menarche may be important in development of aggressive breast cancer in african american women toxoplasma modulates signature pathways of human epilepsy neurodegeneration cancer systems analysis points to links between toxoplasma infection and common brain diseases quantitative heritability of anti citrullinated protein antibody positive and anti citrullinated protein antibody negative rheumatoid arthritis genetic risk factors play role in autoantibody negative rheumatoid arthritis a scalable online tool for quantitative social network assessment reveals potentially modifiable social environmental risks study shows importance of personal social networks on neurological outcomes nosema ceranae can infect honey bee larvae and reduces subsequent adult longevity tiny parasite may contribute to declines in honey bee colonies by infecting larvae chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of alzheimer s disease does a western diet increase risk of alzheimer s disease ? a randomized controlled trial determining variances in ostomy skin conditions and the economic impact advocate trial new skin barrier product reduces costs for ostomy care association of alcohol consumption with selected cardiovascular disease outcomes a systematic review and meta analysis drinking alcohol in moderation protects against heart disease meta analysis finds select forelimb muscles have evolved superfast contractile speed to support acrobatic social displays tropical birds develop superfast wing muscles for mating not flying hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis research challenges use of off label drug to treat osteoarthritis disparities in adverse childhood experiences among individuals with a history of military service greater odds of adverse childhood experiences in those with military service study finds antarctic killer whales make rapid round trip movements to subtropical waters evidence for physiological maintenance migrations ? antarctic killer whales may seek spa like relief in the tropics communicating art virtually ! psychological effects of technological affordances in a virtual museum choosing interactive tools for virtual museums mixes art science an adh b variant and peer drinking in progression to adolescent drinking milestones evidence of a gene by environment interaction best friends drinking can negate protective effects of an alcohol dehydrogenase b gene variant effect of morning exercise with or without breaks in prolonged sitting on blood pressure in older overweight obese adults combining morning exercise with short walking breaks helps control blood pressure local immunomodulation with fas ligand engineered biomaterials achieves allogeneic islet graft acceptance biomaterial particles educate immune system to accept transplanted islets wild inside urban wild boar select natural not anthropogenic food resources wild heart urban wild boars prefer natural food resources effects of mitral chordae tendineae on the flow in the left heart ventricle d simulations reveal synergistic mechanisms of the human heart the growing price gap between more and less healthy foods analysis of a novel longitudinal uk dataset price gap between more and less healthy foods grows pulse pressure is associated with alzheimer biomarkers in cognitively normal older adults high blood pressure in middle age vs old age may predict memory loss newcastle disease virus vectored h and h live vaccines protect chickens from challenge with h n or h n avian influenza viruses vaccines developed for h n h n avian influenza strains resolving molecule specific information in dynamic lipid membrane processes with multi resonant infrared metasurfaces biosensors resolving molecule information in dynamic lipid membrane with metasurfaces bush dogs in central america recent range expansion cryptic distribution or both ? ecologists find bush dog native of south america in remote central costa rica a prospective study of weight training and risk of type diabetes mellitus in menweight training and risk of type diabetes weight training linked to reduced risk of type diabetes nanosized aspirin arg gly asp val delivery of aspirin to thrombus by the target carrier arg gly asp val tetrapeptide a new form of aspirin to overcome aspirin resistance evidence of a chimpanzee sized ancestor of humans but a gibbon sized ancestor of apes last common ancestor of humans and apes weighed about five kilograms nucleus factory on cavitation bubble for amyloid fibril clue for development of diagnosis treatment alzheimer s disease land use change interacts with climate to determine elevational species redistribution how land use and climate change are driving species distribution shifts recombinant growth hormone added to physical therapy in gh deficient adults with complete asia a spine injury growth hormone therapy enhances recovery of patients with spinal damage adaptation optimization of residential buildings under hurricane threat considering climate change in a lifecycle context identifying optimal adaptation of buildings threatened by hurricanes climate change the type ii secreted lipase esterase lesa is a key virulence factor required for xylella fastidiosa pathogenesis in grapevines newly identified enzyme may be the culprit in pierce s disease grapevine damage european cancer mortality predictions for the year with focus on colorectal cancer decline in colorectal cancer deaths is a major success story seven per cent fall in death rates since human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis mice with multiple sclerosis like condition walk again after human stem cell treatment cancerlocator non invasive cancer diagnosis and tissue of origin prediction using methylation profiles of cell free dna computer program developed to diagnose and locate cancer from a blood sample traps and trap placement may affect location of brown marmorated stink bug hemiptera pentatomidae and increase injury to tomato fruits in home gardens stink bug traps may increase damage to tomato fruits immunogenic chemotherapy sensitizes tumors to checkpoint blockade therapy some chemotherapy drugs may improve tumor response to immune checkpoint therapy association among rheumatoid arthritis oral hygiene and periodontitis higher prevalence of periodontal disease in rheumatoid arthritis patients uncovered groundwater depletion in the middle east from grace with implications for transboundary water management in the tigris euphrates western iran region nasa satellites find freshwater losses in middle east crushing virtual cigarettes reduces tobacco addiction and treatment discontinuation crushing cigarettes in a virtual reality environment reduces tobacco addiction a genome wide association study on common snps and rare cnvs in anorexia nervosa gene links to anorexia identified largest genetic study of the eating disorder detects common and rare variants prevalence and correlates of psychotropic medication use in adolescents with an autism spectrum disorder with and without caregiver reported attention deficit hyperactivity disorder new study looks at medication use of kids with autism adhd respiratory virus transmission dynamics determine timing of asthma exacerbation peaks evidence from a population level model common colds at school a primary driver of asthma hospitalizations for children the gard platform for potency assessment of skin sensitizing chemicals new test method aims to predict allergenic potency of chemicals tgf inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence anticancer drug offers potential alternative to transplant for patients with liver failure heterogeneity of chronic graft versus host disease biomarkers the only consistent association is with cxcl and cxcr nk cells researchers discover an early warning sign of transplant rejection a prospective study of sudden cardiac death among children and young adults revealed new insights on causes of sudden cardiac death in the young cell polarity driven instability generates self organized fractal patterning of cell layers fractal patterns spontaneously emerge during bacterial cell growth valacyclovir decreases plasma hiv rna in hsv seronegative individuals a randomized placebo controlled crossover trial common herpes medication reduces hiv levels independent of herpes infection epidural spinal cord stimulation facilitates immediate restoration of dormant motor and autonomic supraspinal pathways after chronic neurologically complete spinal cord injury restoring movement and autonomic function in patients with complete paralysis association between the prevalence of symptoms and health related quality of life in adult survivors of childhood cancer a report from the st. jude lifetime cohort study childhood cancer survivors suffer long term symptoms linked to poor quality of life physical activity in midlife is not associated with cognitive health in later life among cognitively normal older adults physical activity in midlife not linked to cognitive fitness in later years long term study shows telenomus remus a candidate parasitoid for the biological control of spodoptera frugiperda in africa is already present on the continent scientists confirm first report of egg parasitoid in africa to fight fall armyworm longitudinal analysis of hospitalization after spinal cord injury variation based on race and ethnicity impact of race ethnicity in motor complete spinal cord injury are asthmatic patients prone to bone loss ? asthma sufferers may be prone to bone loss a compendium of multi omic sequence information from the saanich inlet water column fifty years of data from a living oxygen minimum lab could help predict the oceans future spectral energy distribution and radio halo of ngc at low radio frequencies astronomers probe swirling particles in halo of starburst galaxy walking in relation to mortality in a large prospective cohort of older u.s. adults walking below minimum recommended levels linked to lower mortality risk preconception urinary phthalate concentrations and sperm dna methylation profiles among men undergoing ivf treatment a cross sectional study father s environmental exposure affects sperm epigenetics study shows the jumbo carbon footprint of a shrimp carbon losses from mangrove deforestation greenhouse gas effect caused by mangrove forest conversion is quite significant visual and modular detection of pathogen nucleic acids with enzyme dna molecular complexes new test kit for quick accurate and low cost screening of diseases helmet use reduces skull fractures in skiers and snowboarders admitted to the hospital role of helmets in reducing skull fractures incurred by children in skiing and snowboarding accidents error robust modes of the retinal population code neurons in the human eye are organized for error correction pediatric emergency department visits and hospitalizations due to food induced anaphylaxis in illinois emergency visits for childhood food allergy on rise in illinois the burden of non acute dying on society dying of cancer and chronic disease in the european union cancer and chronic disease causes almost half of gradual deaths in europe a programmable dual rna guided dna endonuclease in adaptive bacterial immunity programmable dna scissors found for bacterial immune system marine plastics threaten giant atlantic marine protected areas increase in plastics waste reaching remote south atlantic islands effect of selumetinib vs chemotherapy on progression free survival in uveal melanoma drug shows promise for the first time against metastatic melanoma of the eye combustion derived nanoparticles in key brain target cells and organelles in young urbanites culprit hidden in plain sight in alzheimer s disease development culprit hidden in plain sight in alzheimer disease development repeated play reduces video games ability to elicit guilt evidence from a longitudinal experiment violent video games eventually lose their ability to produce guilt in gamers systems analysis of bcl protein family interactions establishes a model to predict responses to chemotherapy new model may help predict response to chemotherapy for colorectal cancer risk of adverse pregnancy outcomes among women practicing poor sanitation in rural india a population based prospective cohort study poor sanitation practices in pregnant women linked to adverse pregnancy outcomes in india shedding new light on the crab with polarized x rays new observations of crab nebula and pulsar reveal polarized emissions persistence length and related conformational properties of semiflexible polymers from dirac propagator high tech future early warning system for hurricanes tornados and volcanic eruptions association between use of the gene recurrence score assay and receipt of chemotherapy among medicare beneficiaries with early stage breast cancer gene recurrence score and receipt of chemotherapy in patients with breast cancer association between obstetric mode of delivery and autism spectrum disorder a population based sibling design study study examines cesarean section delivery autism spectrum disorder lake sediment fecal and biomass burning biomarkers provide direct evidence for prehistoric human lit fires in new zealand reconstructing human history with the help of fecal sterols recent inner ear specialization for high speed hunting in cheetahs cheetahs inner ear is one of a kind vital to high speed hunting deficits in tactile learning in a mouse model of fragile x syndrome deficits in tactile based learning linked to fragile x syndrome an alternate approach to improving healthcare worker influenza vaccination rates health system achieves high flu vaccination rates by mandating masking pd l on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis protein linked to cancer growth drives deadly lung disease probing red blood cell morphology using high frequency photoacoustics listening to blood cells simple test could use sound waves for diagnosing blood related diseases rapidly receding arctic canada glaciers revealing landscapes continuously ice covered for more than years rapidly receding glaciers on baffin island reveal long covered arctic landscapes imaging quantum spin hall edges in monolayer wte scientists image conducting edges in a promising d material lu bp for neurotensin receptor targeted therapy of metastatic pancreatic adenocarcinoma first clinical results novel theranostic approach for treating pancreatic cancer patients shows promise the mouth apparatus of the cambrian gilled lobopodianpambdelurion whittingtoni ancestor of arthropods had the mouth of a penis worm mrnas and protein synthetic machinery localize into regenerating spinal cord axons when they are provided a substrate that supports growth new approach to spinal cord brain injury research identification of aminopyridazine derived antineuroinflammatory agents effective in an alzheimer s mouse model new evidence on easing inflammation of brain cells for alzheimer s disease oup accepted manuscriptuse of a dual antigen rapid diagnostic test to screen children for severe plasmodium falciparum malaria in a high transmission resource limited setting rapid diagnostic test helps distinguish between severe and uncomplicated malaria in africa atrx contributes to epigenetic asymmetry and silencing of major satellite transcripts in the maternal genome of the mouse embryo researchers identify unique marker on mom s chromosomes in early embryo effect of beta blocker dose on survival after acute myocardial infarction low dose beta blockers as effective as high dose after a heart attack percutaneous lymphatic embolization of abnormal pulmonary lymphatic flow as treatment of plastic bronchitis in patients with congenital heart diseaseclinical perspective in child heart patients novel approach improves symptoms of hazardous lymph blockage promiscuous glycan site recognition by antibodies to the high mannose patch of gp broadens neutralization of hiv hitting a moving target aids vaccine could work against changeable site on hiv the politics of climate change in the uk beyond rubber boots and photo ops exploring the politics of climate change in the uk identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay metastasis stem cells in the blood of breast cancer patients discovered foraging and recruitment hotspot dynamics for the largest atlantic loggerhead turtle rookery important foraging hotspots for loggerhead turtle rookery identified human herpesvirus and in febrile status epilepticus the febstat study could roseola virus be behind epilepsy ? childhood virus infection linked to prolonged seizures with fever cytokeratins mediate epithelial innate defense through their antimicrobial properties eye proteins have germ killing power could lead to new antimicrobial drugs study finds combined oral contraceptives and body weight do oral contraceptives cause weight gain ? a primate model birth control pills do not cause weight gain new research suggests pka ampk signaling in relation to adiponectin s antiproliferative effect on multiple myeloma cells new myeloma obesity research shows drugs can team with body s defenses cystatin d cst an ultra early inflammatory biomarker of traumatic brain injury new biomarkers may lead to sports pitch side test for brain injury parent mediated social communication therapy for young children with autism pact long term follow up of a randomised controlled trial parent led early intervention for autism is the first to show reduction in symptom severity through to ages a two component dna prime protein boost vaccination strategy for eliciting long term protective t cell immunity against trypanosoma cruzi chagas disease vaccine shows long term protection in mice expanded autologous regulatory t lymphocyte infusions in als immune cells hold promise in slowing down als endocrine treatment with or without radiotherapy in locally advanced prostate cancer spcg sfuo an open randomised phase iii trial radiotherapy plus hormone therapy cuts prostate cancer death in half shows long term study tumor specific chromosome mis segregation controls cancer plasticity by maintaining tumor heterogeneity genetically diverse cancer cells key to brain tumor resistance prenatal glucocorticoids and maternal smoking during pregnancy independently program adult nicotine dependence in daughters a year prospective study maternal stress hormones maternal smoking increase daughter s risk of nicotine dependence study shows altimeter era emergence of the patterns of forced sea level rise in climate models and implications for the future uneven rates of sea level rise tied to climate change contemporary management of patients undergoing atrial fibrillation ablation in hospital and year follow up findings from the esc ehra atrial fibrillation ablation long term registry more than half of atrial fibrillation patients become asymptomatic after catheter ablation sex drugs and adhd the effects of adhd pharmacological treatment on teens risky behaviors adhd medication reduces risky behavior in children teens research finds diagnostic accuracy of quantitative pcr xpert mtb rif for tuberculous meningitis in a high burden setting a prospective study test may improve diagnosis of tuberculous meningitis in hiv infected individuals systemic administration of a bispecific antibody targeting egfrviii successfully treats intracerebral glioma new immune therapy successfully treats brain tumors in mice the infectiousness of tuberculosis patients coinfected with hiv small numbers of patients with drug resistant tb may account for high proportion of new infections a single photon switch and transistor enabled by a solid state quantum memory semiconductor quantum transistor opens the door for photon based computing partial breast radiotherapy after breast conservation surgery for patients with early breast cancer uk import low trial year results from a multicentre randomised controlled phase non inferiority trial targeted radiotherapy limits side effects of breast cancer treatment modeling deep ocean shipping noise in varying acidity conditions ocean acidification poses little threat to whales hearing study suggests the association between social stressors and home smoking rules among women with infants in the united states high stress for new mothers increases secondhand smoke risk for infants impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects longevity promoting superstar gets revealed in caenorhabditis reproducibility project adjustment among children with relatives who participated in the manhunt following the boston marathon attack mental health issues in children with relatives who participated in manhunt after boston marathon autism specific maternal autoantibodies recognize critical proteins in developing brain researchers identify specific fetal antigens attacked by maternal antibodies obstructive sleep apnea dynamically increases nocturnal plasma free fatty acids glucose and cortisol during sleep untreated sleep apnea shown to raise metabolic and cardiovascular stress surgical complications are associated with omission of chemotherapy for stage iii colorectal cancer surgery complications linked to chemotherapy delay study finds cervical excitatory neurons sustain breathing after spinal cord injury new approach could jumpstart breathing after spinal cord injury common genetic variants acting additively are a major source of risk for autism additive effect of small gene variations can increase risk of autism spectrum disorders responses of carbon uptake and oceanicpco to climate change in the north atlantic a model study with the bergen earth system model uncertain future carbon uptake in the north atlantic the landscape of viral expression and host gene fusion and adaptation in human cancer no viral cause for breast cancer and brain tumors allergic reactions to foods in preschool children enrolled in a prospective observational food allergy study rate of severe reactions higher than thought in young children with food allergies traumatic brain injury history is associated with an earlier age of dementia onset in autopsy confirmed alzheimer s disease. brain injury may boost risk of alzheimer s earlier in life atlantic bluefin tuna a novel multistock spatial model for assessing population biomass comprehensive view of the status of atlantic bluefin tuna the fas fap cav complex regulates il ra secretion in mesenchymal stem cells to accelerate wound healing unraveling how mesenchymal stem cells from gum tissue accelerate wound healing creb targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin loss of certain protein is associated with poor prognosis in breast lung cancer slowing down of north pacific climate variability and its implications for abrupt ecosystem change sea temperature changes linked to mystery north pacific ecosystem shifts noncalcified coronary atherosclerotic plaque and immune activation in hiv infected women plaque composition immune activation explain cardiovascular risk in hiv infected women everolimus treatment of refractory epilepsy in tuberous sclerosis complex drug shows dramatic reduction in seizures in patients with tuberous sclerosis complex annual outcomes with transcatheter valve therapy from the sts acc tvt registry first outcomes report from novel heart surgery registry shows excellent results for tavr first long term behavioral records from cuvier s beaked whales ziphius cavirostris reveal record breaking dives cuvier s beaked whales set new breath hold diving records whales dive to nearly two miles depth for over two hours density dependent coral recruitment displays divergent responses during distinct early life history stages regular coral larvae supply from neighboring reefs helps degraded reefs recover invited article distributed analysis of nonlinear wave mixing in fiber due to forward brillouin scattering and kerr effects researchers map light and sound wave interactions in optical fibers sex differences in lower urinary tract biology and physiology more than just anatomy sex differences in lower urinary tract astrocytes decrease adult neurogenesis during virus induced memory dysfunction via il memory loss from west nile virus may be preventable dramatic declines in snowpack in the western us snowpack levels show dramatic decline in western states u.s. early quality assessment lessens pheromone specificity in a moth love at first sniff male moths go by first impressions the effectiveness of interventions to reduce neurological injuries in rugby union a systematic review headgear mouth guards have little or no impact on reducing concussions in rugby players study finds unsupervised exercise and mobility loss in peripheral artery disease a randomized controlled trial support group home exercise improves mobility for peripheral artery disease patients protein tyrosine phosphatase sap protects against colitis through regulation of ceacam in the intestinal epithelium identification of a novel protein that protects against bowel inflammation sociodemographic patterning of long term diabetes mellitus control following japan s. triple disaster a retrospective cohort study elderly japanese most resilient in wake of triple disaster study finds teaching the blind to find their way by playing video games blind people develop accurate mental map by playing video game male reproductive disorders and fertility trends influences of environment and genetic susceptibility study links environmental and lifestyle factors to reproductive problems infertility in men hypersensitivity of the hippocampal ca region to stress induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause surgical menopause may prime brain for stroke alzheimer s orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies increase in heart rate as blood pressure falls could be early sign of neurological disease single actuator wave like robot saw design modeling and experiments first wave propelled robot swims crawls and climbs using a single small motor rapid inexpensive fingerstick whole blood sensitive specific point of care test for anti toxoplasma antibodies whole blood test for toxoplasmosis is sensitive specific soy consumption and risk of copd and respiratory symptoms a case control study in japan superfood soy linked to reduction in smoker s lung damage risk edc impact molecular effects of developmental fm exposure in wistar rat placenta and fetal forebrain placental accumulation of flame retardant chemical alters serotonin production in rats promoting helix rich structure in silk fibroin films through molecular interactions with carbon nanotubes and selective heating for transparent biodegradable devices making a transparent flexible material of silk and nanotubes in vitro replication of chelonid herpesvirus in organotypic skin cultures from hawaiian green turtles chelonia mydas reptile skin grown in lab for first time helps study endangered turtle disease cytotoxicity and non specific cellular uptake of bare and surface modified upconversion nanoparticles in human skin cells researchers put safety of magic anti cancer bullet to test photoacoustic f mode imaging for scale specific contrast in biological systems hears the pitch team invents a new mode of photoacoustic imaging barley heads east genetic analyses reveal routes of spread through diverse eurasian landscapes living plant varieties reveal ancient migration routes across eurasia intestinal bacteria modify lymphoma incidence and latency by affecting systemic inflammatory state oxidative stress and leukocyte genotoxicity intestinal bacteria linked to white blood cell cancer experimentation versus progression in adolescent drug use a test of an emerging neurobehavioral imbalance model strong working memory puts brakes on problematic drug use soft tissue massage early intervention for relatives whose family members died in palliative cancer care hand and feet massages provide consolation for bereaved relatives nlrc is an inhibitory sensor of pi k mtor pathways in cancer mystery molecule is a key to inhibiting colon cancer year old thalassemia case in sardinia suggests malaria was endemic by the roman period malaria already endemic in the mediterranean by the roman period a new species of illacme cook loomis from sequoia national park california with a world catalog of the siphonorhinidae diplopoda siphonophorida new species of extremely leggy millipede discovered in a cave in california does caregiving cause psychological distress ? the case for familial and genetic vulnerabilities in female twins does caregiving cause psychological stress ? it depends says study of female twins optimal running speed and the evolution of hominin hunting strategies optimal running speed associated with evolution of early human hunting strategies whole genome sequencing reveals local transmission patterns of mycobacterium bovis in sympatric cattle and badger populations first direct evidence linking tb infection in cattle to local badger populations the viral polymerase inhibitor deaza c methyladenosine is a potent inhibitor of in vitro zika virus replication and delays disease progression in a robust mouse infection model experimental drug against hepatitis c slows down zika virus infection in mice live attenuated versus inactivated influenza vaccine in hutterite children a cluster randomized blinded trial flu nasal spray provides similar protection against influenza as flu shot study do violent video games impair the effectiveness of in game advertisements ? the impact of gaming environment on brand recall brand attitude and purchase intention advertising in violent video games results in poor recall negative brand perception significantly greater reduction in breast cancer mortality from post diagnosis running than walking running may be better than walking for breast cancer survival research finds graphene s latest cousin plumbene epitaxial growth on a nano watercube plumbene graphene s latest cousin realized on the nano water cube vaccinate boys as well as girls against hpv it works and it may be cost effective why we should vaccinate boys against hpv as well as girls circadian and melatonin disruption by exposure to light at night drives intrinsic resistance to tamoxifen therapy in breast cancer total darkness at night key to success of breast cancer therapy study shows defining the effect of the p. duplication on cognition behavior and medical comorbidities twenty five point drop in iq caused by lack of gene copy randomized trial comparing fat protein and carbohydrate composition of diets for weight loss for two years just eat less ! heart healthy low cal diets promote weight loss regardless of fat protein and carb content social adversity predicts adhd medication in school children a national cohort study adhd linked to low maternal education lone parents and welfare benefits swedish study finds chemopreventive effects of dietary canola oil on colon cancer development canola oil protects against colon cancer study suggests chance long tails and inference in a non gaussian bayesian theory of vocal learning in songbirds songbird data yields new theory for learning sensorimotor skills sunlight exposure antioxidants and age related macular degeneration sunlight exposure plus low antioxidant levels may place older adults at risk for eye disease vitamin e may affect the life expectancy of men depending on dietary vitamin c intake and smoking vitamin e may increase the life expectancy of males who have high dietary vitamin c intake and smoke less than a pack per day pulmonary neuroendocrine cells function as airway sensors to control lung immune response lung cell found to act as sensor regulator of immune response longitudinal evaluation of work status and productivity after bariatric surgery study examines work status productivity after bariatric surgery dsrna released by tissue damage activates tlr to drive skin regeneration researchers identify drug candidate for skin hair regeneration in scarred burn and trauma victims repeated evolution of power amplified predatory strikes in trap jaw spiders trap jaw spiders strike prey with lightning speed autism occurrence by mmr vaccine status among us children with older siblings with and without autism no association found between mmr vaccine and autism even among children at higher risk randomized trial of a lifestyle program in obese infertile women how lifestyle intervention for weight loss affects birth rates in women with a high bmi combined impact of healthy lifestyle factors on colorectal cancer a large european cohort study bowel cancer risk reduced by adopting multiple healthy behaviors resistance gene directed discovery of a natural product herbicide with a new mode of action natural product that could lead to new class of commercial herbicide arctic sea ice eurasia snow and extreme winter haze in china china s severe winter haze tied to effects of global climate change practice guideline update summary botulinum neurotoxin for the treatment of blepharospasm cervical dystonia adult spasticity and headache report of the guideline development subcommittee of the american academy of neurology guidelines updated botulinum toxin for spasticity headache other brain disorders on demand oil water separation via low voltage wettability switching of core shell structures on copper substrates low cost membrane cleans up light and heavy oils in a single step value of primordial and primary prevention for cardiovascular disease a policy statement from the american heart association heart disease prevention a good investment for individuals communities a pathobiont of the microbiota balances host colonization and intestinal inflammation biologists link gut microbial equilibrium to inflammatory bowel disease chloride homeostasis critically regulates synaptic nmda receptor activity in neuropathic pain research findings reveal potential to reverse cancer related nerve pain oncogenic pik ca mutations reprogram glutamine metabolism in colorectal cancer common colon cancer tumor type blocked in mice clinical trial august nonsteroidal anti inflammatory drugs and the risk for anastomotic failure a report from washington state s surgical care and outcomes assessment program scoap study examines nsaid use risk of anastomotic failure following surgery evidence for sensitized fatigue pathways in patients with chronic fatigue syndrome why exercise magnifies exhaustion for chronic fatigue syndrome patients mechanical tissue resuscitation at the site of traumatic brain injuries reduces the volume of injury and hemorrhage in a swine model vacuum treatment may limit damage after traumatic brain injury cumulative culture can emerge from collective intelligence in animal groups homing pigeons share our human ability to build knowledge across generations agricultural lime disturbs natural strontium isotope variations implications for provenance and migration studies strontium isotope maps are disturbed by agricultural lime nitrogen constraints on terrestrial carbon uptake implications for the global carbon climate feedback worldwide nitrogen deficit constrains carbon dioxide uptake by plants past and future contribution of global groundwater depletion to sea level rise effect of groundwater use using water from wells leads to sea level rise cancels out effect of dams phylogenetics links monster larva to deep sea shrimp oceanic mystery solved connection between monster larva and unique species of shrimp fmrp stalls ribosomal translocation on mrnas linked to synaptic function and autism workings of brain protein suggest therapies for fragile x syndrome and autism double blind placebo controlled randomized clinical trial of verapamil for chronic rhinosinusitis with nasal polyps patients with severe chronic rhinosinusitis show improvement with verapamil treatment cardiopulmonary arrest following administration of cyclomydril eyedrops for outpatient retinopathy of prematurity screening cardiopulmonary arrest in premature infant after cyclomydril eyedrops igm phosphorylcholine autoantibodies and outcome in acute coronary syndromes low levels of lipid antibodies increase complications following heart attack use of a novel vitamin d bioavailability test demonstrates that vitamin d absorption is decreased in patients with quiescent crohn s disease vitamin d absorption is diminished in patients with crohn s disease researchers find linking reef ecology to island building parrotfish identified as major producers of island building sediment in the maldives parrotfish are critical to coral reef island building classical topological order in the kinetics of artificial spin ice finding order in disorder demonstrates a new state of matter adverse cardiac events associated with incident opioid drug use among older adults with copd new opioid use in older adults with copd associated with increased risk of cardiac death association of anti smoking legislation with rates of hospital admission for cardiovascular and respiratory conditions hospital admissions dropped after anti smoking legislation in place evaluation of flow after transcatheter aortic valve replacement in patients with low flow aortic stenosis a secondary analysis of the partner randomized clinical trial one third of patients with low flow aortic stenosis do not improve with transcatheter aortic valve replacement research finds diel co cycles reduce severity of behavioural abnormalities in coral reef fish under ocean acidification new hope for reef fish living in a high co world association of epidural stimulation with cardiovascular function in an individual with spinal cord injury electrical implant reduces invisible symptoms of man s spinal cord injury association of assisted reproductive technologies with arterial hypertension during adolescence children born through ivf may have higher risk of hypertension perimortem trauma in king richard iii a skeletal analysis modern forensic techniques identify most likely cause of king richard iii s death transience of the north american high plains landscape and its impact on surface water the origins of the high plains landscape at base of rocky mountains years of global ocean warming between the challenger expedition and the argo programme new comparison of ocean temperatures reveals rise over the last century human specific histone methylation signatures at transcription start sites in prefrontal neurons short dna strands in genome may be key to understanding human cognition and diseases influence of immune relevant genes on mate choice and reproductive success in wild spawning hatchery reared and wild born coho salmon oncorhynchus kisutch wild coho may seek genetic diversity in mate choice unique growth strategy in the earth s first trees revealed in silicified fossil trunks from china fossils from the world s oldest trees reveal complex anatomy never seen before recollections of childhood bullying and multiple forms of victimization correlates with psychological functioning among college students wounds from childhood bullying may persist into college years study finds gender flexibility stigma and the perceived negative consequences of flexible working in the uk negative views of flexible working prevalent especially among men the effects of submarine canyons and the oxygen minimum zone on deep sea fish assemblages off hawaii land ocean connections how tree trunks leaves and kukui nuts indirectly feed bottom fish in submarine canyons off moloka i hawaii comprehensive serological profiling of human populations using a synthetic human virome your viral infection history in a single drop of blood allergen induced il trans signaling activates t cells to promote type and type airway inflammation blanket approach to asthma treatment not ideal researchers find lower versus higher income populations in the alternative quality contract improved quality and similar spending alternative payment model boosts quality of care for low income patients pathway level risk analysis the net present value of an invasive species policy in the us slowing the insect invasion wood packaging sanitation yields us. billion net benefit helicobacter pylori dna decreases pro inflammatory cytokine production by dendritic cells and attenuates dextran sodium sulphate induced colitis dna from common stomach bacteria minimizes effects of colitis study says partial rupture of a locked patch of the sumatra megathrust during the earthquake sequence another large earthquake off coast of sumatra likely the antisocial brain psychopathy matters a structural mri investigation of antisocial male violent offenders psychopathy linked to specific structural abnormalities in the brain song of my people dialect differences among sympatric social groups of short finned pilot whales in hawai i groups of pilot whales have their own dialects a survey of phthalates and parabens in personal care products from the united states and its implications for human exposure personal care products possible sources of potentially harmful parabens for babies non cultivated plants present a season long route of pesticide exposure for honey bees honeybees pick up astonishing number of pesticides via non crop plants triple oxygen isotope evidence for limited mid proterozoic primary productivity billion year old lake deposit yields clues to earth s ancient biosphere evaluation of spacecraft smoke detector performance in the low gravity environment one detector doesn t fit all for smoke in spacecraft relationship between observed upper mantle structures and recent tectonic activity across the southeastern united states likely cause for recent southeast us earthquakes underside of the north american plate peeling off conservation of eelgrass zostera marina genetic diversity in a mesocosm based restoration experiment seed filled buoys may help restore diverse sea meadows in san francisco bay the association between valence of social media experiences and depressive symptoms negative vs. positive social media experiences and depressive symptoms nalp inflammasome upregulation and casp cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells discovery could help reverse glucocorticoid resistance in some young leukemia patients rapid formation of massive black holes in close proximity to embryonic protogalaxies radiation from nearby galaxies helped fuel first monster black holes effects of an antioxidant enriched multivitamin in cystic fibrosis randomized controlled multicenter trial antioxidant enriched vitamin reduces respiratory illnesses in patients with cystic fibrosis association of childhood lead exposure with adult personality traits and lifelong mental health childhood lead exposure linked to poor adult mental health early death after discharge from emergency departments analysis of national us insurance claims data medicare patients die in the seven days after discharge from the ed enhanced neuronal expression of major histocompatibility complex class i leads to aberrations in neurodevelopment and neurorepair immune protein linked to abnormal brain development may provide clues to schizophrenia and autism sera from preeclampsia patients elicit symptoms of human disease in mice and provide a basis for an in vitro predictive assay preeclampsia advances researchers animal model and potential lab test for diagnosing the disease in people effectiveness of hospital based postpartum procedures on pertussis vaccination among postpartum women changes in hospital orders increase pertussis immunization rates resolving the phylogeny of lizards and snakes squamata with extensive sampling of genes and species evolutionary history of lizards and snakes reconstructed using massive molecular dataset in vitro screen of a small molecule inhibitor drug library identifies multiple compounds that synergize with oncolytic myxoma virus against human brain tumor initiating cells virus drug combination shows improved effectiveness against brain tumor cells gw observation of a solar mass binary black hole coalescence at redshift. are dense star clusters the origin of the gravitational waves discovered by ligo ? high seismic attenuation at a mid ocean ridge reveals the distribution of deep melt the birth and death of a tectonic plate biofilm like extracellular viral assemblies mediate htlv cell to cell transmission at virological synapses biofilms discovery of a new mechanism of virus propagation a multi decade joinpoint analysis of firearm injury severity growing severity of us firearm injuries requiring hospital admission since early s patient and clinician experiences with telehealth for patient follow up care virtual video visits may improve patient convenience without sacrificing quality of care the impact of general anesthesia on child development and school performance a population based study kids exposed to general anaesthestic have poorer development literacy and numeracy scores taking the reins on systems of care for st segment elevation myocardial infarction patients patients get faster life saving treatment in states with policies allowing direct transport to specialized heart attack care hospitals early intervention may prevent the development of posttraumatic stress disorder a randomized pilot civilian study with modified prolonged exposure preventing posttraumatic stress disorder by facing trauma memories an unusual prohibitin regulates malaria parasite mitochondrial membrane potential unique protein is a vulnerability in the malaria parasite association of objectively measured physical activity with cardiovascular risk in mobility limited older adults older adults with limited mobility may lessen heart problems with activity eukaryotic association module in phage wo genomes from wolbachia virus carrying dna of black widow spider toxin allergy related disorders among yrs olds in a general population. the pact study allergy related disorders in yrs olds new insights into allergy related disorders in children molecular archaeoparasitology identifies cultural changes in the medieval hanseatic trading centre of l beck parasites from medieval latrines unlock secrets of human history quantitative proteomics reveals the importance of nitrogen source to control glucosinolate metabolism inarabidopsis thalianaandbrassica oleracea ammonium nitrogen input increases the synthesis of anticarcinogenic compounds in broccoli teen depression and suicide effective prevention and intervention strategies researchers outline effective strategies to prevent teen depression and suicide e readers are more effective than paper for some with dyslexia e readers can make reading easier for those with dyslexia dallas fort worth earthquakes coincident with activity associated with natural gas production texas earthquakes operation of saltwater injection disposal well in area was a plausible cause proapoptotic puma targets stem like breast cancer cells to suppress metastasis drug suppresses spread of breast cancer caused by stem like cells the usability of electronic personal health record systems for an underserved adult population electronic personal health record systems not usable for all association of symptoms following mild traumatic brain injury with posttraumatic stress disorder vs postconcussion syndrome what are the risks of post traumatic stress disorder after an accident ? a novel form of spontaneous tool use displayed by several captive greater vasa parrots coracopsis vasa table. new evidence of tool use discovered in parrots neuropeptide signaling remodels chemosensory circuit composition in caenorhabditis elegans insulin plays role in mediating worms perceptions and behaviors the severity of pandemic h n influenza in the united states from april to july a bayesian analysis severity of h n flu in us during current flu season may be less than feared physical exercise moderates the relationship of apolipoprotein e apoe genotype and dementia risk a population based study couch potatoes face same chance of dementia as those with genetic risk factors research stable iridium dinuclear heterogeneous catalysts supported on metal oxide substrate for solar water oxidation new dual atom catalyst shows promise to yield clean energy by artificial photosynthesis a strategy for the conservation of biodiversity on mid ocean ridges from deep sea mining strategy for no mining zones in the deep sea low plasma cortisol and fecal cortisol metabolite measures as indicators of compromised welfare in domestic horses equus caballus animal welfare potential new indicator of chronic stress in horses hydrolase domain accessible monoacylglycerol controls glucose stimulated insulin secretion novel drug target linked to insulin secretion type diabetes treatment found research review childhood chronic physical illness and adult emotional health a systematic review and meta analysis chronic childhood illness linked with later life mental health problems srgap mice present a neurodevelopmental disorder with schizophrenia related intermediate phenotypes single protein targeted as root biological cause of several childhood psychiatric disorders rates of hospitalized bacterial infection associated with juvenile idiopathic arthritis and its treatment children with juvenile arthritis have higher rates of bacterial infection genetic influences on receptive joint attention in chimpanzees pan troglodytes gene that influences receptive joint attention in chimpanzees gives insight into autism high resolution transcript profiling of the atypical biotrophic interaction between theobroma cacao and the fungal pathogen moniliophthora perniciosa scientists seek cure for devastating witches broom disease of the chocolate tree partial reversal of rett syndrome like symptoms in mecp mutant mice possible treatment for neurological disorder rett syndrome most common basis of autism in girls extent location and clinical significance of non infarct related coronary artery disease among patients with st elevation myocardial infarction half of stemi heart attack patients may have additional clogged arteries melatonin inhibits the caspase cytochrome c caspase cell death pathway inhibits mt receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis melatonin delays als symptom onset and death in mice a dynamic model of transmission and elimination of peste des petits ruminants in ethiopia peste des petits ruminants a model for use in eradicating the disease deep sea hydrothermal vents as natural egg case incubators at the galapagos rift deep sea fish use hydrothermal vents to incubate eggs musicians experience less age related decline in central auditory processing. older musicians experience less age related decline in hearing abilities than non musicians weight change in the early rheumatoid arthritis period and risk for subsequent mortality among women with ra and matched comparators weight loss and risk of death rheumatoid arthritis findings may have wider implications association of coronary artery calcium in adults aged to years with incident coronary heart disease and death calcified plaque raises heart disease risk for younger adults a novel system improves preservation of osteochondral allografts new model for preserving donor tissue will allow more natural joint repair for patients generation of knock in primary human t cells using cas ribonucleoproteins in crispr advance scientists successfully edit human t cells short duration of marriage at conception as an independent risk factor for schizophrenia short period of parental sexual contact prior to pregnancy increases offspring risk of schizophrenia gain of function p mutants co opt chromatin pathways to drive cancer growth mutated p tumor suppressor protein uses epigenetics to drive aggressive cancer growth ditopic complexation of selenite anions or calcium cations by pirenoxine an implication for anti cataractogenesis scientific evidence supports effectiveness of chinese drug for cataracts energy investment needs for fulfilling the paris agreement and achieving the sustainable development goals meeting paris climate targets will require a substantial reallocation of global investment enhanced emission of fluorophores on shrink induced wrinkled composite structures shrink wrap used to enhance detection of infectious disease biomarkers impairment of immunoproteasome function by cigarette smoke and in copd cellular protein shredder is impaired by cigarette smoke and in copd patients physical activity assessed in routine care predicts mortality after a copd hospitalisation physical activity found to decrease risk of early death in copd nr a transcription factors limit car t cell function in solid tumors scientists devise strategies to counteract t cell exhaustion in car t cancer therapies deepem d approaching human level performance on d anisotropic em image segmentation computer approaches human skill for first time in mapping brain insular celtic population structure and genomic footprints of migration historical migrations left genetic footprints on the irish genome china s science technology engineering and mathematics stem research environment a snapshot china s stem research environment in higher education genome sequencing of the staple food crop white guinea yam enables the development of a molecular marker for sex determination crowning the king of the crops sequencing the white guinea yam genome her mtor signaling driven breast cancer cells require er associated degradation to survive study suggests using excess stress to kill therapy resistant breast cancer educational and employment achievements in prelingually deaf children who receive cochlear implants children with cochlear implants appear to achieve similar educational and employment levels as peers perspectives on the causes of exceptionally low snowpack in the western united states west coast record low snowpack in influenced by high temperatures cryptic sympatric diversity in tegu lizards of the tupinambis teguixin group squamata sauria teiidae and the description of three new species three new species identified amongst the tegu lizard family efficacy of varenicline combined with nicotine replacement therapy vs varenicline alone for smoking cessation varenicline combined with nicotine patch improves smoking cessation rates what s in a name ? effect of breed perceptions labeling on attractiveness adoptions length of stay for pit bull type dogs pit bull label may triple length of stay in dog shelters peptic ulcer and childhood adversities experienced by working aged people childhood adversities have predictive role in peptic ulcer learning to understand phrases by embedding the dictionary ai crossword solving application could make machines better at understanding language definition differences and internal variability affect the simulated arctic sea ice melt season new satellite keeps close watch on antarctic ice loss body size and physical activity in relation to incidence of chronic obstructive pulmonary disease obesity large waist size risk factors for copd ethnic variations in the occurrence of colonic neoplasms new research shows impact of crohn s disease on brain function cyanobacterial neurotoxin n methylamino l alanine bmaa in shark fins neurotoxins in shark fins a human health concern global burden of mental disorders among children aged years mental disorders among leading causes of illness in children worldwide acute neuroinflammation impairs context discrimination memory and disrupts pattern separation processes in hippocampus brain inflammation dramatically disrupts memory retrieval networks study finds invited review mineral absorption mechanisms mineral interactions that affect acid base and antioxidant status and diet considerations to improve mineral status in depth mineral review provides foundational resource for dairy scientists high signal intensity in the dentate nucleus and globus pallidus on unenhanced t weighted mr images relationship with increasing cumulative dose of a gadolinium based contrast material contrast agent linked with brain abnormalities on mri hiclip reveals the in vivo atlas of mrna secondary structures recognized by staufen structure of genetic messenger molecules reveals key role in diseases lignin engineering in field grown poplar trees affects the endosphere bacterial microbiome modifying the structure of wood alters plant microbiome anti malarial drug artesunate restores metabolic changes in experimental allergic asthma common herbal based anti malarial drug effective in controlling asthma study suggests practices and perspectives of college instructors on addressing religious beliefs when teaching evolution evolution and religion new insight into instructor attitudes in arizona effectiveness of vitamin b in treating recurrent aphthous stomatitis a randomized double blind placebo controlled trial vitamin b identified as an effective canker sore therapy study suggests brain region specific organoids using mini bioreactors for modeling zikv exposure sophisticated mini brains add to evidence of zika s toll on fetal cortex a nano in micro system for enhanced stem cell therapy of ischemic diseases nano in micro stem cell delivery could rescue blood flow after injury structural insights into the bacterial carbon phosphorus lyase machinery bacteria s secret weapon against pesticides antibiotics revealed results of the neuroblate system first in humans phase i clinical trial for recurrent glioblastoma new minimally invasive mri guided laser treatment for brain tumor found to be promising in study first ecological study of the bawean warty pig sus blouchi one of the rarest pigs on earth fewer than mature bawean warty pigs in existence comprehensive transcriptional analysis of early stage urothelial carcinoma new research paves way for improved individual treatment of patients with cancer dopamine depletion impairs bilateral sensory processing in the striatum in a pathway dependent manner mechanisms behind sensory deficits in parkinson s disease most genetic risk for autism resides with common variation genetic risk for autism stems mostly from common genes differential connexin function enhances self renewal in glioblastoma in lab tests new therapy slows spread of deadly brain tumor cells is higher serum cholesterol associated with altered tendon structure or tendon pain ? a systematic review high cholesterol linked to heightened risk of tendon abnormalities and pain abstinence funding was not associated with reductions in hiv risk behavior in sub saharan africa promoting abstinence fidelity for hiv prevention is ineffective study finds diagnostic accuracy of multiparametric magnetic resonance imaging to identify clear cell renal cell carcinoma in ct a renal masses state of the art mri technology bypasses need for biopsy microbial and biogeochemical dynamics in glacier forefields are sensitive to century scale climate and anthropogenic change microbial colonizers of arctic soils are sensitive to future climate change unexpected gynecologic malignancy diagnosed after hysterectomy performed for benign indications risk of unexpected sarcoma being discovered after hysterectomy appears fairly low location isn t everything timing of spawning aggregations optimizes larval replenishment location isn t everything but timing is for certain spawning fish histatins are the major wound closure stimulating factors in human saliva as identified in a cell culture assay licking your wounds scientists isolate compound in human saliva that speeds wound healing preoperative medical testing in medicare patients undergoing cataract surgery unnecessary preoperative testing still done on cataract patients contrasting patterns of coral bleaching susceptibility in suggest an adaptive response to thermal stress global warming threat to coral reefs can some species adapt ? modifiable risk factors discriminate memory trajectories in non demented aging precision factors and targets for promoting healthier brain aging and preventing dementia ? aging gracefully study identifies factors for healthy memory at any age chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice long term benefits of senolytic drugs on vascular health in mice cancer immunotherapy with recombinant poliovirus induces ifn dominant activation of dendritic cells and tumor antigen specific ctls poliovirus therapy for recurrent glioblastoma has three year survival rate of percent using lifestyle factors to identify individuals at higher risk of inflammatory polyarthritis results from the european prospective investigation of cancer norfolk and the norfolk arthritis register the epic noar study links between lifestyle and risk of developing rheumatoid arthritis the impact of surgery on global climate a carbon footprinting study of operating theatres in three health systems first study to measure the carbon footprint of surgery suggests where emissions reductions are possible earthquake early warning shakealert system west coast wide production prototype west coast earthquake early warning system continues progress toward public use dopamine is a safe antiangiogenic drug which can also prevent fluorouracil induced neutropenia dopamine a safe anti angiogenic drug in cancer treatment study shows aborted propagation of the ethiopian rift caused by linkage with the kenyan rift new light into the recent evolution of the african rift valley yoga for chronic neck pain a pilot randomized controlled clinical trial yoga shown effective for treating chronic neck pain lifespan of effector memory cd t cells determined by replication incompetent integrated hiv provirus new method for tracking t cells in hiv patients noise induced plasticity of kcnq and hcn channels underlies vulnerability and resilience to tinnitus cause of resilience to tinnitus and potential drug therapy identified a direct and melanopsin dependent fetal light response regulates mouse eye development light exposure during pregnancy key to normal eye development raman detection of hydrohalite formation avoiding accidents on icy roads by deicing where salt will not work new laser technology could reduce accidents on icy roads identifying genetic variants that affect viability in large cohorts humans still evolving large scale study of genetic data shows periodontal disease and breast cancer prospective cohort study of postmenopausal women periodontal disease associated with increased breast cancer risk in postmenopausal women gold nanoparticles with different charge and moiety induce differential cell response on mesenchymal stem cell osteogenesis development of gold nanoparticles that control osteogenic differentiation of stem cells use of the refill function through an online patient portal is associated with improved adherence to statins in an integrated health system personal health record associated with improved medication adherence increased vegf a promotes multiple distinct aging diseases of the eye through shared pathomechanisms angiogenesis factor found to promote three age related diseases of the eye are cyanobacteria involved in ciguatera fish poisoning like outbreaks in new caledonia ? potential new threat for coral reefs and health of communities in the tropics link between molecular mobility and order parameter during liquid liquid transition of a molecular liquid a fascinating phase transition from one liquid state to another longitudinal study of traffic crashes violations and suspensions among young drivers with adhd teens with adhd get more traffic violations for risky driving have higher crash risk association of changes in air quality with bronchitic symptoms in children in california southern california s reduction in smog linked to major improvement in children s health intramolecular isotopic evidence for bacterial oxidation of propane in subsurface natural gas reservoirs deep microbes key contribution to earth s carbon cycle integrating farm and air pollution studies in search for immunoregulatory mechanisms operating in protective and high risk environments environmental exposures early in life modify immune responses new genus of extinct holocene gibbon associated with humans in imperial china new gibbon genus discovered in ancient chinese tomb does the reaction of abstaining smokers to the smell of other people s cigarettes predict relapse ? smell of smoke does not trigger relapse in quitters new research shows early identification of sepsis in hospital inpatients by ward nurses increases day survival simple measures cut sepsis deaths nearly in half absolute weight loss and not weight loss rate is associated with better improvements in metabolic health faster weight loss no better than slow weight loss for health benefits floating along buoyancy levels dispersal and survival of western baltic fish eggs stratification determines fate of fish stocks in baltic sea the habitats humans provide factors affecting the diversity and composition of arthropods in houses scientists investigate how different houses and lifestyles affect which bugs live with us how to attain the ambitious goals for health reform in china smoking set to kill one in three young men in china crispr cas knockin mice for genome editing and cancer modeling researchers engineer cas animal models to study disease inform drug discovery association of amine biomarkers with incident dementia and alzheimer s disease in the framingham study study identifies potential biomarker for alzheimer s disease the role of cancer in marijuana and prescription opioid use in the united states a population based analysis from to insights on marijuana and opioid use in people with cancer pharmacologically relevant intake during chronic free choice drinking rhythms in selectively bred high alcohol preferring mice new strain of lab mice mimics human alcohol consumption patterns paper based tuberculosis diagnostic devices with colorimetric gold nanoparticles a rapid paper based diagnostic test for tuberculosis mek inhibitors reverse growth of embryonal brain tumors derived from oligoneural precursor cells promise of better targeted treatments now possible in children s brain cancer noninvasive language mapping in patients with epilepsy or brain tumors non invasive mapping helps to localize language centers before brain surgery metal sulfides as excellent co catalysts for h o decomposition in advanced oxidation processes faster cheaper wastewater treatment through improved oxidation reactions elevated plasma inflammatory markers in individuals with intermittent explosive disorder and correlation with aggression in humans markers of inflammation in blood linked to aggressive behaviors efficient physical embedding of topologically complex information processing networks in brains and computer circuits brains worms and computer chips have striking similarities disturbance from traditional fire management in subalpine heathlands increases afro alpine plant resilience to climate change climate change mitigation project threatens local ecosystem resilience in ethiopia statement of the european respiratory society and the european region of the international union against tuberculosis and lung disease call for urgent actions to ensure access to early diagnosis and care of tuberculosis among refugees health experts call for improved tb care for refugees breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks researchers find indirect path to attack breast cancer stem cells first record of a putative novel invasive corbicula lineage discovered in the illinois river illinois usa team discovers a new invasive clam in the us neurofibromin modulates adult hippocampal neurogenesis and behavioral effects of antidepressants genetic manipulation boosts growth of brain cells linked to learning enhances effects of antidepressants regulation of bdnf exocytosis and gabaergic interneuron synapse by the schizophrenia susceptibility gene dysbindin repairing the brain two genes unlock potential for treatment of schizophrenia impact of coal mining on stream biodiversity in the us and its regulatory implications coal mining reduces abundance richness of aquatic life gene pleiotropy constrains gene expression changes in fish adapted to different thermal conditions doing more means changing less when it comes to gene response new study shows artisanal fish fences pose broad and unexpected threats to the tropical coastal seascape fish fences across the tropical seas having large scale devastating effects transcription activator like effector proteins induce the expression of the frataxin gene new gene therapy strategy boosts levels of deficient protein in friedreich s ataxia a traffic light food labeling intervention increases consumer awareness of health and healthy choices at the point of purchase traffic light labeling increases attention to nutritional quality of food choices serum metabolomics of slow vs. rapid motor progression parkinson s disease a pilot study researchers find chemical signature for fast form of parkinson s rf knockout allows ribosomal incorporation of unnatural amino acids at multiple sites bionic bacteria may help make new drugs biofuels artificially enhanced bacteria capable of producing new kinds of synthetic chemicals high sensitivity intravascular photoacoustic imaging of lipid laden plaque with a collinear catheter design new imaging technology allows scientists to peer even deeper into fatty arteries cyanide antidotes for mass casualties water soluble salts of the dithiane sulfanegen from mercaptopyruvate for intramuscular administration toward a better cyanide antidote for terrorist attacks and other mass casualty events component resolved evaluation of the content of major allergens in therapeutic extracts for specific immunotherapy of honeybee venom allergy immunotherapy against bee stings in some cases incomplete crystal structure of the conserved herpesvirus fusion regulator complex gh gl map of herpes virus protein suggests a new drug therapy multimodal chemosensory circuits controlling male courtship in drosophila researchers track neural circuits driving a fly s choice of a mate thinking more or feeling less ? explaining the foreign language effect on moral judgment communicating in a foreign language takes emotion out of decision making age related patterns of spine injury in children involved in all terrain vehicle accidents atv related accidents and children pediatric orthopaedic surgeons show age related patterns of spine injury in atv injuries micrornas induce a permissive chromatin environment that enables neuronal subtype specific reprogramming of adult human fibroblasts human skin cells transformed directly into motor neurons a versatile aav producer cell line method for scalable vector production of different serotypes faster scalable method for producing aav based gene transfer vectors offshore forcing on the pressure point of the west florida shelf anomalous upwelling and its influence on harmful algal blooms no major red tide outbreaks on florida s west coast this year researchers predict amyloid and tau alzheimer s disease related pathology is reduced by toll like receptor stimulation targeted immune system booster removes toxic proteins in mouse model of alzheimer s disease risk of acute myocardial infarction with nsaids in real world use bayesian meta analysis of individual patient data heightened risk of heart attacks found with common painkillers in routine use design implications of extended producer responsibility for durable products durability vs. recyclability dueling goals in making electronics more sustainable timing of large earthquakes during the past years along the santa cruz mountains segment of the san andreas fault at mill canyon near watsonville california san andreas fault in santa cruz mountains large earthquakes more frequent than previously thought generating knockout rats by transposon mutagenesis in spermatogonial stem cells genetically modified rats produced using novel sperm stem cell technique promoting axon regeneration in the adult cns by modulation of the melanopsin gpcr signaling enhancing neuronal activity promotes axon regeneration in adult central nervous system recently identified mutations in the ebola virus makona genome do not alter pathogenicity in animal models despite mutations in makona ebola virus disease consistent in mice monkeys livebirth after uterus transplantation from a deceased donor in a recipient with uterine infertility first baby born via uterus transplant from a deceased donor maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring maternal insulin resistance changes pancreas development increases risk of metabolic disorders in offspring functional impact of global rare copy number variation in autism spectrum disorders world s largest dna scan reveals rare variants that disrupt gene activity in autistic children achievement of paris climate goals unlikely due to time lags in the land system climate goals of the paris agreement impact of land use social interaction modulates autonomic inflammatory and depressive like responses to cardiac arrest and cardiopulmonary resuscitation social isolation worsens cardiac arrest effects on heart regulation delayed postnatal loss of p q type calcium channels recapitulates the absence epilepsy dyskinesia and ataxia phenotypes of genomic cacna a mutations epilepsy and coordination disorders important role for the cerebellum poststent ballooning is associated with increased periprocedural stroke and death rate in carotid artery stenting re inflating balloon after carotid stenting appears to double risk of stroke and death gut microbiota are related to parkinson s disease and clinical phenotype gut microbiota and parkinson s disease connection made xnd regulates the global recombination landscape in caenorhabditis elegans protein sets stage for exchanges of dna code in eggs and sperm cell shape independent ftsz dynamics in synthetically remodeled bacterial cells sculpting bacteria into extreme shapes reveals the rugged nature of cell division increases in melanoma among adolescent girls and young women in california trends by socioeconomic status and uv radiation exposure melanoma diagnosis in women associated with higher socioeconomic status discordant reporting of nonmedical opioid use in a nationally representative sample of us high school seniors the struggle to maintain accurate data on the prevalence of opioid abuse orthogonal muscle fibres have different instructive roles in planarian regeneration surprising roles for muscle in tissue regeneration study finds long range electrostatics induced two proton transfer captured by neutron crystallography in an enzyme catalytic site neutrons probe structure of enzyme critical to development of next generation hiv drugs an implantable wireless neural interface for recording cortical circuit dynamics in moving primates novel wireless brain sensor unveiled wireless broadband rechargeable fully implantable epigenome wide scans identify differentially methylated regions for age and age related phenotypes in a healthy ageing population key genes that switch off with aging highlighted as potential targets for anti aging therapies right brain a reading specialist with alexia without agraphia teacher interrupted new technique enables patient with word blindness to read again rates and correlates of binge drinking among college students with disabilities united states how serious is binge drinking among college students with disabilities ? large scale genetic survey provides insights into the captive management and reintroduction of giant pandas largest genetic survey to date shows major success of giant panda breeding programs the combined landscape of denisovan and neanderthal ancestry in present day humans a world map of neanderthal and denisovan ancestry in modern humans alcohol attributable cancer deaths and years of potential life lost in the united states alcohol consumption is a leading preventable cause of cancer death in u.s. experts say archaic hominin introgression in africa contributes to functional salivary muc genetic variation in saliva clues to a ghost species of ancient human the mammalian spermatogenesis single cell transcriptome from spermatogonial stem cells to spermatids world s most comprehensive digital roadmap to unlock male infertility a synthetic optogenetic transcription device enhances blood glucose homeostasis in mice genes at the flick of a light switch human cells fitted with synthetic signaling cascade notch signaling controls the balance of ciliated and secretory cell fates in developing airways lung disease top notch decisions in the developing airways bring insights into lung disease long distance growth and connectivity of neural stem cells after severe spinal cord injury neural stem cells regenerate axons in severe spinal cord injury functional recovery in rats environmental fate of rna interference pesticides adsorption and degradation of double stranded rna molecules in agricultural soils processes determining fate of new rna pesticide in soils finding the right bricks for molecular legos a data mining approach to organic semiconductor design chemical data mining boosts search for new organic semiconductors evaluation of the role of biocolonizations in the conservation state of machu picchu peru the sacred rock biocolonizer species are putting the conservation of the granite at machu picchu at risk secondary gold structures relics of past biogeochemical transformations and implications for colloidal gold dispersion in subtropical environments mining bacteria with midas touch for efficient gold processing activation of gabaergic neurons in the interpeduncular nucleus triggers physical nicotine withdrawal symptoms nicotine withdrawal traced to very specific group of brain cells impaired acuity of the approximate number system underlies mathematical learning disability dyscalculia poor gut sense of numbers contributes to persistent math difficulties underuse of prevention and lifestyle counseling in patients with peripheral artery disease quality of care for peripheral artery disease is low study suggests an experimental study of chest compression during chiropractic manipulation of the thoracic spine using an anthropomorphic test device chiropractic manipulation results in little or no risk of chest injury study suggests the receptor tyrosine kinase axl is required at multiple steps of the metastatic cascade during her positive breast cancer progression breast cancer discovery of a protein linked to metastasis a vision for vaccines against hiv tuberculosis and malaria vision of vaccines for malaria tb and hiv aids functional recovery after moderate severe traumatic brain injury a role for cognitive reserve ? higher education associated with better recovery from traumatic brain injury thirty two years of continuous assessment reveal first year university biology students in australia are rapidly abandoning beliefs in theistic involvement in human origins steep decline in student belief that god created humans year australian study reveals moderate alcohol consumption enhances vaccine induced responses in rhesus macaques moderate alcohol consumption boosts body s immune system study suggests variation of seizure frequency with ovulatory status of menstrual cycles greater seizure frequency seen in women with epilepsy during anovulatory cycle marine dna viral macro and microdiversity from pole to pole pole to pole study of ocean life identifies nearly marine viruses disrupted intrinsic connectivity among default dorsal attention and frontoparietal control networks in individuals with chronic traumatic brain injury brain connectivity disruptions may explain cognitive deficits in people with brain injury dog characteristics and future risk of asthma in children growing up with dogs no link between hypoallergenic dogs and lower risk of childhood asthma flow dependent epigenetic dna methylation regulates endothelial gene expression and atherosclerosis disturbance in blood flow leads to epigenetic changes atherosclerosis a new ancient lineage of frog anura nyctibatrachidae astrobatrachinae subfam. nov. endemic to the western ghats of peninsular india meet india s starry dwarf frog lone member of newly discovered ancient lineage sevi the semen enhancer of hiv infection along with fragments from its central region form amyloid fibrils that are toxic to neuronal cells hiv study leads to insights into deadly infection dietary patterns and alcohol consumption during pregnancy secondary analysis of avon longitudinal study of parents and children significant connections between diet and drinking during pregnancy the dinosaurian ichnofauna of the lower cretaceous valanginian barremian broome sandstone of the walmadany area james price point dampier peninsula western australia australia s jurassic park the world s most diverse placenta on a chip a novel platform to study the biology of the human placenta researchers design placenta on a chip to better understand pregnancy what s love got to do with it ?adolescent romantic networks and substance use what s love got to do with it ? drinking smoking and teen romance brain amygdala volume increases in veterans and active duty military personnel with combat related posttraumatic stress disorder and mild traumatic brain injury brain area tied to emotions is larger in vets service members with mild tbi and ptsd sexually transmitted infection among adolescents and young adults with attention deficit hyperactivity disorder a nationwide longitudinal study adhd medications may reduce the risk of sexually transmitted infection crispr targeting reveals a reservoir of common phages associated with the human gut microbiome gut microbes battle a common set of viruses shared by global populations risk reduction for hiv positive african american and latino men with histories of childhood sexual abuse programs succeed in reducing risky sex among hiv positive minority men sumo gene transfer improves cardiac function in a large animal model of heart failure novel gene therapy works to reverse heart failure fertility after ectopic pregnancy the demeter randomized trial fertility after ectopic pregnancy first randomised trial finds reassuring evidence on the effect of different treatments zika virus infection damages the testes in mice zika infection causes reduced fertility low testosterone in male mice hospitalized prevalence and year mortality for ibd record linkage study distinct demographic profiles between crohn s disease and ulcerative colitis predicting year risk of developing pneumonia in older adults without dementia predicting the risk for developing pneumonia in older adults a new basal elasmosaurid sauropterygia plesiosauria from the lower cretaceous of germany new ancient sea reptile found in germany the earliest of its kind phenotypic assays identify azoramide as a small molecule modulator of the unfolded protein response with antidiabetic activity new tool identifies novel compound targeting causes of type diabetes advanced paternal age and early onset of schizophrenia in sporadic cases not confounded by parental polygenic risk for schizophrenia advanced paternal age increases risk of early onset schizophrenia in offspring locomotor endurance predicts differences in realized dispersal between sympatric sexual and unisexual salamanders salamanders brave miles of threatening terrain for the right sex partner relationships of prop taste phenotype taste receptor genotype and oral nicotine replacement use genetic sensitivity to bitter tastes may impact adherence to oral smoking cessation products first principles plasma simulations of black hole jet launching how to escape a black hole simulations provide new clues about powerful plasma jets precision engineering for prrsv resistance in pigs macrophages from genome edited pigs lacking cd srcr domain are fully resistant to both prrsv genotypes while maintaining biological function gene edited pigs show signs of resistance to major viral disease targeting breast to brain metastatic tumours with death receptor ligand expressing therapeutic stem cells stem cell based therapy promising for treatment of breast cancer metastases in the brain standard model fermions and infinite dimensional r symmetries infinite dimensional symmetry opens up possibility of a new physics and new particles managed wildfire effects on forest resilience and water in the sierra nevada wildfire management vs. fire suppression benefits forest and watershed well being problematic alcohol consumption and acute subjective drug effects in past year ayahuasca users a large international self selecting online survey traditional amazonian drug linked to improved sense of wellbeing study suggests tools and terms for understanding illegal wildlife trade it s not all about tigers and criminals illegal wildlife trade responses need nuance role of inflammatory pathways blood mononuclear cells and gut derived bacterial products in alcohol dependence breakdown in gut barriers to bacteria may promote inflammation and craving in alcoholics military personnel who seek health and mental health services outside the military military personnel seeking mental health care outside of the military ptp b controls non mitochondrial oxygen consumption by regulating rnf to promote tumour survival during hypoxia breast cancer cells use newfound pathway to survive low oxygen levels in tumors gender differences in indoor tanning habits and location tanning beds and risky behavior linked in men translation from a dmd exon ires results in a functional dystrophin isoform that attenuates dystrophinopathy in humans and mice discovery of new form of dystrophin protein could lead to therapy for some duchenne muscular dystrophy patients policy options for the world s primary forests in multilateral environmental agreements world s primary forests on the brink study concludes physical activity associated bone loading during adolescence and young adulthood is positively associated with adult bone mineral density in men lifelong physical activity increases bone density in men poor immunogenicity not vaccine strain egg adaptation may explain the low h n influenza vaccine effectiveness in past encounters with the flu shape vaccine response the effect of price on preference consistency over time time versus money ? placing a value on buyer s remorse radial versus femoral access for coronary interventions across the entire spectrum of patients with coronary artery disease a meta analysis of randomized trials inserting stents through the wrist reduces bleeding death rates in heart disease patients priority threat management of invasive animals to protect biodiversity under climate change controlling feral animals plants will save unique species billions of dollars traumatic brain injury causes selective cd dependent peripheral lymphocyte activation that exacerbates neurodegeneration head injury causes immune system to attack brain new study finds equatorial anisotropy in the inner part of earth s inner core from autocorrelation of earthquake coda earth s surprise inside geologists unlock mysteries of the planet s inner core association of low density lipoprotein cholesterol related genetic variants with aortic valve calcium and incident aortic stenosis key to aortic valve disease prevention lowering cholesterol early direct lineage conversion of adult mouse liver cells and b lymphocytes to neural stem cells direct generation of neural stem cells could enable transplantation therapy zika virus preferentially replicates in the female reproductive tract after vaginal inoculation of rhesus macaques zika monkey study suggests worse fetal effects for vaginal versus mosquito transmission field deployable quantitative rapid identification of active ebola virus infection in unprocessed blood. breakthrough in rapid mass screening for the ebola virus deep mapping gentrification in a large canadian city using deep learning and google street view tracking urban gentrification one building at a time trastorno de estr s postraum tico en escolares tras el terremoto de lorca espa a en percent of minors in lorca suffer post traumatic stress a year after earthquake developmentally based scaling of leaf venation architecture explains global ecological patterns hacking code of leaf vein architecture solves mysteries allows predictions of past climate catechins protect neurons against mitochondrial toxins and hiv proteins via activation of the bdnf pathway green tea and chocolate compounds offer hope for patients with hiv associated cognitive impairment rgs is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra parkinson s disease study focuses on regulation of dopamine levels value of transit as reflected in u.s. single family home premiums surrounding real estate shows increase in value if near transit station a content analysis of functional recovery strategies of breast cancer survivors facilitated intervention can improve quality of life for breast cancer survivors ipsc derived macrophages effectively treat pulmonary alveolar proteinosis in csf rb deficient mice single transplantation of therapeutic macrophages improves rare lung disease in mice eyewitness memory in face to face and immersive avatar to avatar contexts virtual avatar to avatar interviews may improve eyewitness testimony meta analysis reveals genome wide significance at q for nonsyndromic clefting of both the lip and the palate and functional analyses implicate grem as a plausible causative gene breakthrough made in cleft lip and palate research uptake whole body distribution and depuration of nanoplastics by the scallop pecten maximus at environmentally realistic concentrations billions of nanoplastics accumulate in marine organisms within six hours determinants of changes in sedentary time and breaks in sedentary time among and year old children sedentary behavior increases with age even in active children mds associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance cancer associated mutations are common in patients with unexplained low blood counts semaphorin d signaling defects are associated with anomalous pulmonary venous connections mutation causing wrong way plumbing explains one type of blue baby syndrome parasite exposure drives selective evolution of constitutive versus inducible defense nature s inbuilt immune defense could protect industrial bacteria from viruses unifying latitudinal gradients in range size and richness across marine and terrestrial systems similarities in species diversity range in both terrestrial birds marine bivalves single cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy improved gene editing process for duchenne muscular dystrophy domestic cats felis catus discriminate their names from other words hello kitty cats recognize their own names according to new japanese research imaging of vanadium in microfossils a new potential biosignature hope to discover sure signs of life on mars ? new research says look for the element vanadium molecular basis for activation of lecithin cholesterol acyltransferase by a compound that increases hdl cholesterol how a small molecule promotes removal of excess cholesterol a phase ii study of fornix deep brain stimulation in mild alzheimer s disease deep brain stimulation continues to show promise for patients with mild alzheimer s disease gut bacteria selectively promoted by dietary fibers alleviate type diabetes fiber fermenting bacteria improve health of type diabetes patients dna nanotweezers and graphene transistor enable label free genotyping biosensor chip detects single nucleotide polymorphism wirelessly with higher sensitivity pervaporation methodology for improving alcohol free beer quality through aroma recovery improving taste of alcohol free beer with aromas from regular beer chronic lack of breeding by gal pagos blue footed boobies and associated population decline lack of breeding threatens blue footed boobies survival colorectal cancer trends in california and the need for greater screening of hispanic men hispanic men in california need more screening for colorectal cancer study finds periocular triamcinolone versus intravitreal triamcinolone versus intravitreal dexamethasone implant for the treatment of uveitic macular edema the periocular versus intravitreal corticosteroids for uveitic macular edema point trial most effective treatment approaches for uveitic macular edema engineered lentiviral vectors pseudotyped with a cd receptor and a fusogenic protein can target cells expressing hiv envelope proteins scientist develops virus that targets hiv using a virus to kill a virus physiological parameter monitoring from optical recordings with a mobile phone hold the phone for vital signs researchers turn a smart phone into a medical monitor establishing social dialog between buildings and their users research fosters communication between smart buildings and people patching of lipid rafts by molecular self assembled nanofibrils suppresses cancer cell migration new mechanobiology technique to stop cancer cell migration determination of somatic and cancer stem cell self renewing symmetric division rate using sphere assays go figure math model may help researchers with stem cell cancer therapies maternal immune activation central nervous system development and behavioral phenotypes influences of maternal diabetes on fetal heart development mutualistic strategies minimize coextinction in plant disperser networks new study upends established models of forecasting coextinction in complex ecosystems ambient air pollution and overweight and obesity in school aged children in barcelona spain children exposed to air pollution at school may be at greater risk of overweight and obesity increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type model of a migraine indicates increased neuronal excitability as a possible cause randomized controlled trial of mind reading and in vivo rehearsal for high functioning children with asd unique emotion recognition treatment leads to significant improvement in children with high functioning autism a barley rop gtpase activating protein associates with microtubules and regulates entry of the barley powdery mildew fungus into leaf epidermal cells new switch in resistance to plant diseases discovered genetic diversity and protective efficacy of the rts s as malaria vaccine genomic study sheds light on protective effects of malaria vaccine candidate de novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability overlap in genes altered in schizophrenia autism intellectual disability quality of diagnostic staging in patients with bladder cancer a process outcomes link quality of biopsy directly linked to survival in patients with bladder cancer rotation in c ii emitting gas in two galaxies at a redshift of. astronomers detect whirlpool movement in earliest galaxies swirling gases soon after big bang surges in trematode prevalence linked to centennial scale flooding events in the adriatic ancient italian fossils reveal risk of parasitic infections due to climate change substance p mediates proinflammatory cytokine release from mesenteric adipocytes in inflammatory bowel disease patients role of intra abdominal fat in ibd uncovered serum sclerostin decreases following months of resistance or jump training in men with low bone mass weight bearing exercises promote bone formation in men time to treatment with endovascular thrombectomy and outcomes from ischemic stroke a meta analysis earlier treatment with surgery to remove blood clot linked with less disability following stroke emergence of highly transparent photovoltaics for distributed applications transparent solar technology represents wave of the future physiological suppression of lipotoxic liver damage by complementary actions of hdac and scap srebp molecular pillars team up to protect liver from toxic fat buildup cross talk between progesterone receptors and retinoic acid receptors in regulation of cytokeratin positive breast cancer cells explaining failure of retinoic acid trials against breast cancer timing key early triassic productivity crises delayed recovery from world s worst mass extinction arctic gives clues on worst mass extinction of life high chinese elm pollen counts in the fall in atlanta georgia chinese elm trees linked to increased fall pollen counts in atlanta thalamic amplification of cortical connectivity sustains attentional control new role found for brain region focusing attention during decision making estimates of global regional and national incidence prevalence and mortality of hiv the global burden of disease study rate of new hiv infections increased in countries over past decade dietary shifts may trigger dysbiosis and mucous stools in giant pandas ailuropoda melanoleuca panda feces study provides insights into microbiome reproductive troubles investigating the genetic architecture of dementia with lewy bodies a two stage genome wide association study dementia with lewy bodies unique genetic profile identified conceptualizing socio hydrological drought processes the case of the maya collapse the demise of the maya civilization water shortage can destroy cultures bayesian probabilities for mw. earthquakes in the aleutian islands from a regionally scaled global rate new research estimates probability of mega earthquake in the aleutians the ideal distribution of farmers explaining the euro american settlement of utah agricultural productivity drove euro american settlement of utah critical thresholds and tangible targets for ecosystem based management of coral reef fisheries study uncovers a predictable sequence toward coral reef collapse gray matter volume in left rostral middle frontal and left cerebellar cortices predicts frontal executive performance in alcoholic subjects frontal lobe damage from alcohol may occur before general mental status challenges mating activates the heme peroxidase hpx in the sperm storage organ to ensure fertility in anopheles gambiae targeting sperm protection in mosquitoes could help combat malaria antiretroviral therapies in women after single dose nevirapine exposure nih studies influence revision of who guidelines for treating hiv infected women infants road injuries and relaxed licensing requirements for driving light motorcycles in spain a time series analysis access to motorbikes without taking prior exam increases number of accidents study finds autologous bone marrow derived cell therapy combined with physical therapy induces functional improvement in chronic spinal cord injury patients new hope for reversing the effects of spinal cord injury biological one way functions for secure key generation better security achieved with randomly generating biological encryption keys profoundly different prion diseases in knock in mice carrying single prp codon substitutions associated with human diseases new models advance the study of deadly human prion diseases observational signatures of massive black hole formation in the early universe looking back in time to watch for a different kind of black hole potential for sulfoxaflor to improve conservation biological control ofaphis glycines hemiptera aphididae in soybean sulfoxaflor found to be less harmful to insect predators than broad spectrum insecticides high throughput proteomics reveals the unicellular roots of animal phosphosignaling and cell differentiation a short jump from single celled ancestors to animals assessment of the potential for international dissemination of ebola virus via commercial air travel during the west african outbreak three people infected with ebola predicted to fly from west africa every month if no exit screening takes place dietary fibre intake and risk of cardiovascular disease systematic review and meta analysis greater dietary fiber intake associated with lower risk of heart disease cell type specific chromatin states differentially prime squamous cell carcinoma tumor initiating cells for epithelial to mesenchymal transition researchers define for the first time how the cancer cell of origin controls invasive metastatic properties of tumor cells high voltage electrical stimulation for the management of stage iii and iv pressure ulcers among adults with spinal cord injury demonstration of its utility for recalcitrant wounds below the level of injury functional electrical stimulation cycling promotes recovery in chronic spinal cord injury range expansion of tropical pyrosomes in the northeast pacific ocean sea pickles are adapting to the pacific northwest ultracompact silicon conductive oxide nanocavity modulator with. lambda cubic active volume big energy savings building the world s smallest electro optic modulator inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice aspartame may prevent not promote weight loss by blocking intestinal enzyme s activity real time monitoring of geosmin and methylisoborneol representative odor compounds in water pollution using bioelectronic nose with human like performance human like nose can sniff out contamination in drinking water association of telomere length of peripheral blood leukocytes with hematopoietic relapse malignant transformation and survival in severe aplastic anemia shorter biological marker length in aplastic anemia patients linked to higher relapse death rates th century variola virus reveals the recent history of smallpox th century strain of smallpox retrieved from partial mummified remains of lithuanian child tolerability safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate alone and combined in patients with lacunar ischaemic stroke the lacunar intervention laci trial a randomised clinical trial drugs to prevent stroke and dementia show promise in early trial a microrna hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice new approach to promote regeneration of heart tissue crf receptor regulates anxiety behavior via sensitization of ht receptor signaling biological link between stress anxiety and depression identified biofabrication of multifunctional nanocellulosic d structures a facile and customizable route a simple method developed for d bio fabrication based on bacterial cellulose emergency management of anaphylaxis due to an unknown trigger an year follow up study in canada suboptimal inconsistent treatment for anaphylaxis due to unknown cause protein kinase ck enables regulatory t cells to suppress excessive th responses in vivo scientists identify a new population of regulatory t cells the phlpp phosphatase is a druggable driver of prostate cancer progression enzyme phlpp could be a viable drug target for treating prostate cancer referral to a new psychological therapy service is associated with reduced utilisation of healthcare and sickness absence by people with common mental health problems a before and after comparison referral to talking therapies may cut use of health services and sick leave uk study finds dna mismatch repair status and colon cancer recurrence and survival in clinical trials of fluorouracil based adjuvant therapy dna repair system affects colon cancer recurrence and survival venus flytrap carnivorous lifestyle builds on herbivore defense strategies venus flytrap exploits plant defenses in carnivorous lifestyle a century of rice water weevil coleoptera curculionidae a history of research and management with an emphasis on the united states rice growers new resource against the rice water weevil effects of seal predation on a modelled marine fish community and consequences for a commercial fishery seals not competing with irish fishing stocks according to new research a bio inspired polymeric gradient refractive index grin human eye lens human eye gives researchers visionary design for new more natural lens technology fluxengine a flexible processing system for calculating atmosphere ocean carbon dioxide gas fluxes and climatologies new research helps solve the riddle of the ocean carbon conundrum using decoys to expand the recognition specificity of a plant disease resistance protein by switching bait biologists trick plants bacterial defense into attacking virus urgent care peripheral nerve blocks for refractory trigeminal neuralgia peripheral nerve block provides some with long lasting pain relief for severe facial pain breathlessness and restrictive lung disease an important diabetes related feature in patients with type diabetes high prevalence of restrictive lung disease in people with type diabetes mitogenomes uncover extinct penguin taxa and reveal island formation as a key driver of speciation new islands happy feet study reveals island formation a key driver of penguin speciation democracy derived ? new trajectories in pluripotent stem cell research banning u.s. federal funding for human embryonic stem cell research would derail related work experts argue new polyps old tricks controversy about removing benign bowel lesions fear of missing bowel cancer may be exposing patients to unnecessary risks tdp pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in als ftd cellular traffic jam seen in als ftd supports drug strategy maternal smoking during pregnancy and physical control and coordination among offspring smoking during pregnancy may harm the child s motor control and coordination practice patterns in medicaid and non medicaid asthma admissions for kids with asthma hospital care is comparable for medicaid and non medicaid patients association between neuraxial analgesia cancer progression and mortality after radical prostatectomy a large retrospective matched cohort study pain drugs used in prostate gland removal linked to cancer outcome study finds fetal brain lesions after subcutaneous inoculation of zika virus in a pregnant nonhuman primate study details zika virus disrupting fetal brain development during pregnancy tandem amplification of a chromosomal segment harboring enolpyruvylshikimate phosphate synthase locus confers glyphosate resistance in kochia scoparia invasive weed kochia s resistance to well known herbicide stems from increase in gene copies transpressional rupture of an unmapped fault during the haiti earthquake haiti earthquake caused by unknown fault blamed fault ready to produce large earthquake the role of violent media preference in cumulative developmental risk for violence and general aggression media violence cited as critical risk factor for aggression a comparison of the prevalence of dementia in the united states in and dementia on the downslide especially among people with more education study finds identification of virus encoded micrornas in divergent papillomaviruses new screening approach reveals importance of micrornas in papillomavirus life cycle transcriptomic and morphophysiological evidence for a specialized human cortical gabaergic cell type scientists identify a new kind of human brain cell the link between maternal sleep and permissive parenting during late adolescence sleep better parent better study shows link between maternal sleep and permissive parenting effects of current exercise and diet on late life cognitive health of former college football players former football players prone to late life health problems study finds risk factors of sudden cardiac death in the young a multiple year community wide assessment obesity other risks play large role in sudden cardiac arrest among the young effects of intensive diet and exercise on knee joint loads inflammation and clinical outcomes among overweight and obese adults with knee osteoarthritis the idea randomized clinical trial pdf diet and exercise produces greater improvement in knee pain function vitamin d status and its relationship to body fat final height and peak bone mass in young women lack of vitamin d causes weight gain and stunts growth in girls the jujube genome provides insights into genome evolution and the domestication of sweetness acidity taste in fruit trees jujube genome study sheds light on fruit tree s domestication altered taok activity causes autism related neurodevelopmental and cognitive abnormalities through rhoa signaling researchers pinpoint gene responsible for neurodevelopmental disorders including autism glioblastoma survival in the united states improved after food and drug administration approval of bevacizumab a population based analysis brain cancer survival improved following fda approval of bevacizumab confined pseudo shocks as an energy source for the active solar corona solar tadpole like jets seen with nasa s iris add new clue to age old mystery extracting message inter departure time distributions from the human electroencephalogram examining the brain as a neural information super highway effect on mortality of point of care urine based lipoarabinomannan testing to guide tuberculosis treatment initiation in hiv positive hospital inpatients a pragmatic parallel group multicountry open label randomised controlled trial low cost min tb test could help reduce tuberculosis death rate among patients with hiv in sub saharan africa honey bee colony performance and health are enhanced by apiary proximity to us conservation reserve program crp lands honey bee colonies more successful by foraging on non crop fields requests for abortion in latin america related to concern about zika virus exposure zika virus alerts may have prompted uptick in abortion requests in latin america a tale of three cities omegacam discovers multiple sequences in the color magnitude diagram of the orion nebula cluster a tale of three stellar cities three different populations of baby stars international travel by persons with medical comorbidities understanding risks and providing advice one in five persons seeking pre travel advice are high risk travelers the notch and wnt pathways regulate stemness and differentiation in human fallopian tube organoids fallopian tube organoids promise better understanding of ovarian cancer infertility mental illness and reduction of gun violence and suicide bringing epidemiologic research to policy gun violence and mental illness study addresses perception vs. reality the complementarity between tax avoidance and manager diversion evidence from tax haven firms tax havens and limited regulation increase risk for shareholders study shows predictors trends and outcomes among older patients years of age associated with beta blocker use in patients with stable angina undergoing elective percutaneous coronary intervention beta blockers following angioplasty show little benefit for some older patients insufficient sleep duration is associated with dietary habits screen time and obesity in children insufficient sleep in children is associated with poor diet obesity and more screen time association of hospital resources and imaging choice for appendicitis in pediatric emergency departments at some hospitals kids with suspected appendicitis get worse care at night terminal pleistocene alaskan genome reveals first founding population of native americans evidence of previously unknown population of ancient native americans research reveals asymptomatic infection and unrecognised ebola virus disease in ebola affected households in sierra leone a cross sectional study using a new non invasive assay for antibodies to ebola virus undetected ebola infection in international healthcare workers very unlikely olfactory ensheathing cells a trojan horse for glioma gene therapy olfactory cells may act as trojan horse carry anticancer therapy to deadly brain tumors association between systolic blood pressure and dementia in the whitehall ii cohort study role of age duration and threshold used to define hypertension dementia risk increased in year olds with blood pressure below hypertension threshold effect of chlorhexidine whole body bathing on hospital acquired infections among trauma patients antiseptic cloths associated with reduced rate of treatment resistant bacteria in the trauma center the flexible lek phymatopus hectathe gold swift demonstrates the evolution of leking and male swarming via a hotspot lepidoptera hepialidae variety is the spice of humble moth s sex life particulate air pollutants apoe alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models air pollution may lead to dementia in older women the safety of adult male circumcision in hiv infected and uninfected men in rakai uganda circumcision safe in both hiv infected and hiv uninfected men study finds effects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder making the brain take notice of faces in autism sea surface temperatures in cooler climate stages bear more similarity with atmospheric co forcing atmospheric co drove climate change during longest interglacial longitudinal relations among language skills anger expression and regulatory strategies in early childhood toddlers language skills predict less anger by preschool discovery of a hypersaline subglacial lake complex beneath devon ice cap canadian arctic scientists discover first super salty subglacial lakes in canadian arctic dog rivalry impacts following behavior in a decision making task involving food how dogs interact with others plays a role in decision making tearing of indian mantle lithosphere from high resolution seismic images and its implications for lithosphere coupling in southern tibet new model reveals rips in earth s mantle layer below southern tibet detection of tuberculosis in hiv infected and uninfected african adults using whole blood rna expression signatures a case control study rna signatures from suspected tb patients could form basis of diagnostic test diagnosis of cystic fibrosis consensus guidelines from the cystic fibrosis foundation updated cystic fibrosis diagnosis guidelines can help in diagnosis personalized treatment mixed lineage kinase pharmacological inhibition attenuates murine nonalcoholic steatohepatitis of mice and cheeseburgers experimental drug reverses obesity related liver disease maternal stress during pregnancy increases neonatal allergy susceptibility role of glucocorticoids keep calm moms maternal stress during pregnancy linked to asthma risk in offspring redactions in protocols for drug trials what industry sponsors concealed drug trial protocol redactions by industry sponsors exposed the next generation of scenarios for climate change research and assessment alternative futures of a warming world potential human responses to climate change will be integrated into future models rapid cross density ocean mixing at mid depths in the drake passage measured by tracer release undersea mountains provide crucial piece in climate prediction puzzle decision making in people who relapsed to driving under the influence of alcohol decision making deficits related to driving under the influence are often undetected subclinical hypocalcemia plasma biochemical parameters lipid metabolism postpartum disease and fertility in postparturient dairy cows low levels of blood calcium in dairy cows may affect cow health productivity harnessing genetic complexity to enhance translatability of alzheimer s disease mouse models a path toward precision medicine better mouse model built to enable precision medicine research for alzheimer s tmpl a transmembrane protein required for intracellular redox homeostasis and virulence in a plant and an animal fungal pathogen pathogen protection and virulence dark side of fungal membrane protein revealed sexual orientation differences in positive youth development the mediational role of bullying victimization bullying hinders positive youth development for sexual minority youth aerographite ultra lightweight flexible nanowall carbon microtube material with outstanding mechanical performance world record lightest material in the world produced all in the name of work ? nonwork orientations as predictors of salary career satisfaction and life satisfaction nonwork orientations are related to higher career and life satisfaction high resolution ams dates from shubayqa northeast jordan reveal complex origins of late epipalaeolithic natufian in the levant archaeologists revise chronology of the last hunter gatherers in the near east role of boundary layer diffusion in vapor deposition growth of chalcogenide nanosheets the case of ges researchers create nanoflowers for energy storage solar cells knowledge of pelvic floor disorders in a population of community dwelling women knowledge about incontinence pelvic organ prolapse lower among women of color the lipid kinase pi p k is an intracellular gtp sensor for metabolism and tumorigenesis scientist identifies energy sensor as potential target for cancer drugs early lineage specification defines alveolar epithelial ontogeny in the murine lung specialized lung cells appear very early in development methodology of thermoelectric power factor enhancement by controlling nanowire interface powered by windows enhanced power factor in transparent thermoelectric nanowire materials cooperation in criminal organizations kinship and violence as credible commitments discussing violence acts as a stronger bond than blood ties for gang members regional variability in the sensitivity of caribbean reef fish assemblages to ocean warming reefs help protect vulnerable caribbean fish from climate change colonic transit time is related to bacterial metabolism and mucosal turnover in the gut food s transit time through body is a key factor in digestive health most impactful factors on the health related quality of life of a geriatric population with cancer what factors affect quality of life in older patients with cancer ? tobacco in post conflict settings the case of iraq when the smoke clears tobacco control in post conflict settings cumulative burden of comorbid mental disorders substance use disorders chronic medical conditions and poverty on health among adults in the u.s.a. more than of americans now have at least one chronic health condition mental disorder or substance use issue comprehensive genomic characterization of head and neck squamous cell carcinomas molecular alterations in head and neck cancers uncovered by study atlas data indicate forest dependent bird species declines in south africa researchers investigate decline in south africa s forest birds diversity and ecological correlates of red fluorescence in marine fishes why fish send red signals in the deep blue sea improving transitions of care for hospitalized patients on warfarin changes to hospital electronic health records could improve care of patients on warfarin negative aging attitudes predict greater reactivity to daily stressors in older adults good attitudes about aging help seniors handle stress epidemiologic comparison of injured high school basketball athletes reporting to emergency departments and the athletic training setting . million basketball injuries to high school athletes in seasons research finds reflexive culture in adolescents and adults with group a streptococcal pharyngitis suspect strep throat ? re check negative rapid test results with lab culture a general scaling law reveals why the largest animals are not the fastest why tyrannosaurus was a slow runner and why the largest are not always the fastest considerations in the radiologic evaluation of the pregnant orthopaedic patient some radiation okay for expectant mother and fetus study suggests the power of the web a systematic review of studies of the influence of the internet on self harm and suicide in young people how internet affects young people at risk of self harm suicide microbial reconstitution reverses maternal diet induced social and synaptic deficits in offspring a single species of gut bacteria can reverse autism related social behavior in mice re analysis of all cause mortality in the u.s. preventive services task force evidence report on colorectal cancer screening crc screening with flexible sigmoidoscopy reduces risk for death safety and efficacy of upadacitinib in patients with rheumatoid arthritis and inadequate response to conventional synthetic disease modifying anti rheumatic drugs select next a randomised double blind placebo controlled phase trial prospect of a new treatment for rheumatoid arthritis human umbilical cord plasma proteins revitalize hippocampal function in aged mice protein in human umbilical cord blood rejuvenates old mice s impaired learning memory a combination of routine blood analytes predicts fitness decrement in elderly endurance athletes sports medicine blood results help to predict fitness improvements in older marathon runners baseline telomere length and effects of a multidomain lifestyle intervention on cognition the finger randomized controlled trial is telomere length associated with the cognitive response to a lifestyle intervention ? supporting evidence from the finger trial body donation after medically assisted death an emerging consideration for donor programs ethical questions raised on body donation after medically assisted death measurement of red blood cell mechanics during morphological changes new microscopy technique reveals mechanics of blood cell membranes clonal culturing of human embryonic stem cells on laminin e cadherin matrix in defined and xeno free environment new method increases supply of embryonic stem cells cellular resolution maps of x chromosome inactivation implications for neural development function and disease color coded cells reveal patchwork pattern of x chromosome silencing in female brains association between influenza infection and vaccination during pregnancy and risk of autism spectrum disorder no association between mother flu in pregnancy increased child autism risk association of inpatient vs outpatient onset of st elevation myocardial infarction with treatment and clinical outcomes high mortality associated with stemi heart attacks that occur in hospitalized patients regulation of alternative vegf a mrna splicing is a therapeutic target for analgesia medical discovery first step on path to new painkillers brain connectivity and psychiatric comorbidity in adolescents with internet gaming disorder wired for gaming brain differences in compulsive video game players a cell autonomous mammalian hr clock coordinates metabolic and stress rhythms a hour biological clock coordinates essential bodily functions qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation gene deletion allows cancer cells to thrive when migrating within the brain influence of environmental and genetic factors linked to celiac disease risk on infant gut colonization by bacteroides species influence of breast milk vs. formula and genetics on gut microbiota composition could help prevent celiac disease the bar sinister does handlebar level damage the pelvic floor in female cyclists ? handlebar level can affect sexual health of female cyclists frequent indoor tanning among new jersey high school students frequent indoor tanning among teens shows correlation with smoking social media use ganglion specific splicing of trpv underlies infrared sensation in vampire bats what steers vampire bats to blood heat detecting molecules on noses discovered biofield therapies helpful or full of hype ? a best evidence synthesis biofield therapies helpful or full of hype ? review looks at reiki therapeutic touch and healing touch detection of coronal magnetic activity in nearby active supermassive black holes mystery of coronae around supermassive black holes deepens adolescent consumption of sports and energy drinks linkages to higher physical activity unhealthy beverage patterns cigarette smoking and screen media use sports energy drink consumption linked to negative behaviors simvastatin for the prevention of exacerbations in moderate to severe copd no benefit found in taking statin drugs for copd exacerbation prevention the risk of cancer with the use of recombinant human bone morphogenetic protein in spine fusion study questions cancer link with bone growth factor for spinal surgery adolescent drinking onset and its adult consequences among men a population based study from india more than threefold surge in number of male teens drinking alcohol in india food animals and antimicrobials impacts on human health evidence supports ban on growth promotion use of antibiotics in farming evidence that comt genotype and proline interact on negative symptom outcomes in schizophrenia and bipolar disorder response to common schizophrenia bipolar treatment dictated by gene type poor sleep quality and compromised visual working memory capacity good sleep quality and good mood lead to good working memory with age multiscale control of nanocellulose assembly transferring remarkable nanoscale fibril mechanics to macroscale fibers world s strongest bio material outperforms steel and spider silk insights from the geographic spread of the lyme disease epidemic lyme disease cases among children are on the rise in western pennsylvania leptin receptor expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow key to identifying enriching mesenchymal stem cells found redox dependent modulation of t type ca channels in sensory neurons contributes to acute anti nociceptive effect of substance p pain paradox discovery provides route to new pain control drugs the nature of giant clumps in distant galaxies probed by the anatomy of the cosmic snake anatomy of a cosmic snake reveals structure of distant galaxies differences in prevalence treatment and outcomes of asthma among a diverse population of children with equal access to care findings from a study in the military health system racial disparities in asthma exist even among children with equal access to health care serum sntf increases in concussed professional ice hockey players and relates to the severity of post concussion symptoms protein elevated in blood predicts post concussion symptom severity in professional athletes advances in the understanding of same sex and opposite sex sexual harassment a preference for casual sex increases risk of harassment multivariate analysis of maize disease resistances suggests a pleiotropic genetic basis and implicates a gst gene corn gene provides resistance to multiple diseases study shows jnk dependent acute liver injury from acetaminophen or tumor necrosis factor tnf requires mitochondrial sab expression in mice scientists identify key protein linked to acute liver failure inhibition of protein protects liver from acetaminophen toxicity in mice effects of the absence of apolipoprotein e on lipoproteins neurocognitive function and retinal function normal cognition in patient without apolipoprotein e risk factor for alzheimer s incomplete immune reconstitution despite virologic suppression in hiv infected children and adolescents for most children with hiv low immune cell count cells rebound after treatment lithospheric thinning beneath rifted regions of southern california southern california s tectonic plates revealed in detail universal voluntary testing and treatment for prevention of hiv transmission universal voluntary hiv testing and treatment ? research agenda outlined hypoxia impacts large adults first consequences in a warming world age matters to antarctic clams age matters when it comes to adapting to the effects of climate change reef fidelity and migration of tiger sharks galeocerdo cuvier across the coral sea tracking the deep sea paths of tiger sharks understanding the habitat use and migration patterns of large sharks central sleep disordered breathing predicts incident atrial fibrillation in older males sleep disordered breathing patients at greater risk for atrial fibrillation a whole brain volumetric approach in overweight obese children examining the association with different physical fitness components and academic performance. the activebrains project brains of children with a better physical fitness possess a greater volume of gray matter cacao seeds are a super fruit a comparative analysis of various fruit powders and products chocolate is a super fruit rich source of antioxidants pharmacological cognitive enhancement treatment of neuropsychiatric disorders and lifestyle use by healthy people neuroscientists call for immediate action to determine the dangers and benefits of cognitive enhancing drug use in healthy people measuring and estimating the effect sizes of copy number variants on general intelligence in community based samples estimating the effect of genetic mutations on neurodevelopmental disorders more accurately defective intestinal mucin type o glycosylation causes spontaneous colitis associated cancer in mice findings light the way for new treatments in colitis colon cancer consequences of climate change for biotic disturbances in north american forests climate change creates complicated consequences for north america s forests association between use of a scalp cooling device and alopecia after chemotherapy for breast cancer scalp cooling device may help reduce hair loss for women with breast cancer receiving chemotherapy dietary inflammatory index bone mineral density and risk of fracture in postmenopausal women results from the women s health initiative anti inflammatory diet could reduce risk of bone loss in women fluidal pyroclasts reveal the intensity of peralkaline rhyolite pumice cone eruptions rare volcanic rocks lift lid on dangers of little studied eruptions in vivox ray imaging reveals improved airway surface hydration after a therapy designed for cystic fibrosis new x ray imaging lets researchers see live the effectiveness of cystic fibrosis treatments inhibitory gradient along the dorsoventral axis in the medial entorhinal cortex a brake in the head new insights into the working of the brain differential nuclease sensitivity pro fi ling of chromatin reveals biochemical footprints coupled to gene expression and functional dna elements in maize maize analysis yields whole new world of genetic science inhibition of gsk abolishes bacterial induced periodontal bone loss in mice scientist discovers mechanism to reduce inflammation and subsequent bone loss related to gum disease passenger mutations confound interpretation of all genetically modified congenic mice tool developed for more accurate interpretation of biomedical research trends in prevalence of functional disability in rheumatoid arthritis compared with the general population rheumatoid arthritis patients affected by disabilities well in advance of diagnosis electrical guidance of human stem cells in the rat brain neural stem cells steered by electric fields in rat brain infertility infertility treatment and achievement of pregnancy in female survivors of childhood cancer a report from the childhood cancer survivor study cohort strong pregnancy outcomes for survivors of childhood cancer linking spring phenology with mechanistic models of host movement to predict disease transmission risk new mapping tool tracks elk migration to reduce brucellosis risk understanding the transformation speciation and hazard potential of copper particles in a model septic tank system using zebrafish to monitor the effluent colon septic tank unique at times stinky study caudal anaesthesia of the infraorbital nerve for diagnosis of idiopathic headshaking and caudal compression of the infraorbital nerve for its treatment in horses headshaking in horses new treatment has success rate local retention dispersal and fluctuating connectivity among populations of a coral reef fish data revealing migrations of larval reef fish vital for designing networks of marine protected areas dog ownership has unknown risks but known health benefits we need evidence based policy politically driven legislation targeting dangerous dogs has had little impact minority hiv drug resistance mutations are present in antiretroviral treatment na ve populations and associate with reduced treatment efficacy sensitive testing reveals drug resistant hiv with possible consequences for treatment acute computer related injuries treated in u.s. emergency departments computer related injuries on the rise young children particularly at risk modeling the interplay between neurons and astrocytes in autism using human induced pluripotent stem cells induced pluripotent stem cells show astrocyte neuron impact on brain pathology in autism pinaverium reduces symptoms of irritable bowel syndrome in a multicenter randomized controlled trial pinaverium shows promising results for treatment of irritable bowel syndrome novel mechanism of foxo phosphorylation in glucagon signaling in control of glucose homeostasis researchers zero in on potential therapeutic target for diabetes associated diseases association between osteoporosis treatment and severe periodontitis in postmenopausal women estrogen therapy shown effective in reducing tooth and gum diseases in postmenopausal women cloning of macaque monkeys by somatic cell nuclear transfer meet zhong zhong and hua hua the first monkey clones produced by method that made dolly a systematic review of associations between environmental exposures and development of asthma in children aged up to years reported link between early life exposure to paracetamol and asthma overstated microseismic events associated with the oroville dam spillway oroville dam earthquakes in february related to spillway discharge lipidomic profiles of the heart and circulation in response to exercise versus cardiac pathology a resource of potential biomarkers and drug targets key differences between the exercise trained heart and failing heart paternal psychological stress reprograms hepatic gluconeogenesis in offspring stressed mouse dads give their offspring high blood sugar fear populism and the geopolitical landscape the sleeper effect of neurotic personality traits on regional voting behavior in the brexit and trump elections regional levels of fear associated with trump and brexit votes psychology study shows the technical and anatomical aspects of the world s first near total human face and maxilla transplant first near total face and upper jaw transplant appears successful novel dlk independent neuronal regeneration in caenorhabditis elegans shares links with activity dependent ectopic outgrowth discovery in roundworms may one day help humans with spinal cord injury and paralysis a high performance self regenerating solar evaporator for continuous water desalination solar evaporator offers a fresh route to fresh water evidence of damage from exotic invasive earthworm activity was highly correlated to sugar maple dieback in the upper great lakes region earthworms at the root of sugar maple decline extra mediterranean glacial refuges in barred and common grass snakes natrix helvetica n. natrix cool snake warmth loving grass snake survived the ice age in central europe genome wide single cell analysis of recombination activity and de novo mutation rates in human sperm entire genetic sequence of individual human sperm determined weekend warriors can early invasive management of stable non st elevation acute coronary syndromes save healthcare dollars ? should hospitals keep cardiac catheterization labs open on weekends ? randomized controlled trial of preconception interventions in infertile women with polycystic ovary syndrome weight loss exercise improve fertility in women with polycystic ovary syndrome genetic identification of a neural circuit that suppresses appetite genetic identification of neural circuit that suppresses appetite montefiore einstein center for the aging brain preliminary data new evaluation model delivers improved care for patients with cognitive disorders outcomes of hiv infected patients receiving care at multiple clinics visits to multiple hiv clinics linked to poorer outcomes relating protein functional diversity to cell type number identifies genes that determine dynamic aspects of chromatin organisation as potential contributors to organismal complexity genes that separate humans from fruit flies found molecular basis of substrate induced permeation by an amino acid antiporter d structure required for function of some vital cell transporters resolved accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks new material developed for accelerated skin regeneration in major wounds emergence and spread of basal lineages of yersinia pestis during the neolithic decline an ancient strain of plague may have led to the decline of neolithic europeans elevated surface chlorophyll associated with natural oil seeps in the gulf of mexico in gulf of mexico microbes thrive above natural oil seeps identification of scintillation signatures on gps signals originating from plasma structures detected with eiscat incoherent scatter radar along the same line of sight new research on northern lights will improve satellite navigation accuracy diagnosis of postoperative urinary retention using a simplified ultrasound bladder measurement simple ultrasound measure can diagnose postoperative urinary retention divergence s in nodal signaling between aggressive melanoma and embryonic stem cells re expression of an embryonic signaling pathway in melanoma utilizes different receptors preoperative opioid use as a predictor of adverse postoperative self reported outcomes in patients undergoing spine surgery opioid use prior to spine surgery linked to diminished patient reported outcomes the sacred ibis debate the first test of evolution how sacred ibis mummies provided the first test of evolution metastatic lymph node burden and survival in oral cavity cancer study provides new guidelines for assessing severity of head and neck cancers apoe stabilization by exercise prevents aging neurovascular dysfunction and complement induction long term aerobic exercise prevents age related brain changes temperature size responses match latitudinal size clines in arthropods revealing critical differences between aquatic and terrestrial species cold blooded animals grow bigger in the warm on land but smaller in warm water overweight and obesity reduce the likelihood of achieving sustained remission in early rheumatoid arthritis results from the canadian early arthritis cohort study studies examine the effects of weight on patients with rheumatoid arthritis comparative study of early secondary nasal revisions and costs in patients with clefts treated with and without nasoalveolar molding nasoalveolar molding use for cleft lip palate reduces the number of surgeries and cost of care imported ornamental fish are colonized with antibiotic resistant bacteria ornamental fish industry faces increasing problems with antibiotic resistance left handedness among a community sample of psychiatric outpatients suffering from mood and psychotic disorders is left handedness higher among those suffering from psychosis ? reprogramming cell fate with a genome scale library of artificial transcription factors designer switches of cell fate could streamline stem cell biology mda il regulates the mirna processing enzyme dicer through downregulation of mitf scientists home in on microrna processing for novel cancer therapies smarter lunchrooms can address new school lunchroom guidelines and childhood obesity smarter lunchrooms make lunch choices child s play defining the generalist specialist niche for pleistocene homo sapiens homo sapiens developed a new ecological niche that separated it from other hominins impact of prior use of four preventive medications on outcomes in patients hospitalized for acute coronary syndrome results from cpacs study medication to prevent heart attacks linked with reduced heart attack severity household tobacco smoke and admission weight predict severe bronchiolitis in infants independent of deprivation prospective cohort study household smoke increases severity of bronchiolitis in babies bottom up processes influence the demography and life cycle phenology of hawaiian bird communities climate influenced changes in flowering fruiting also affect bird abundance activities association study in african admixed populations across the americas recapitulates asthma risk loci in non african populations genetic clues to high rates of asthma in those of african ancestry systematic revision of symbiodiniaceae highlights the antiquity and diversity of coral endosymbionts diverse symbionts of reef corals have endured since age of dinosaurs factor v leiden mutation and thromboembolism risk in women receiving adjuvant tamoxifen for breast cancer gene mutation increases thromboembolism risk in women taking tamoxifen quantum state transfer from an ion to a photon into the quantum internet at the speed of light isolated and joint effects of tobacco and alcohol consumption on risk of alzheimer s disease alcohol consumption may protect against risk of alzheimer s disease particularly in female nonsmokers study finds different genetic mechanisms control foliar and tuber resistance to phytophthora infestans in wild potato solanum verrucosum wild potato germplasm holds key to disease resistance a pluripotent stem cell based model for post implantation human amniotic sac development amniotic sac in a dish stem cells form structures that may aid of infertility research fibrinogen induces microglia mediated spine elimination and cognitive impairment in an alzheimer s disease model a new culprit in cognitive decline in alzheimer s disease a diverse suite of pharmaceuticals contaminates stream and riparian food webs drug pollution concentrates in stream bugs passes to predators in water and on land did advances in global surveillance and notification systems make a difference in the h n pandemic ? a retrospective analysis assessing disease surveillance and notification systems after a pandemic quantitative high resolution epigenetic profiling of cpg loci identifies associations with cord blood plasma homocysteine and birth weight in humans link between folic acid supplementation in pregnancy dna methylation and birth weight in newborn babies microbially induced sedimentary structures recording an ancient ecosystem in theca.. billion year old dresser formation pilbara western australia evidence of. billion year old bacterial ecosystems found in australia cellular factors promoting resistance to effective treatment of glioma with oncolytic myxoma virus common chemotherapeutic agent reduces resistance to virus therapy in brain tumor patients two new species of gastrodia gastrodieae epidendroideae orchidaceae from okinawa island ryukyu islands japan two new species of orchids discovered in okinawa muscle stem cells exhibit distinct clonal dynamics in response to tissue repair and homeostatic aging researchers track muscle stem cell dynamics in response to injury and aging health and human rights concerns of drug users in detention in guangxi province china china s paradoxical policies on hiv and drug use threaten health experts argue orthotopic patient derived xenografts of paediatric solid tumours powerful resource to advance treatment of pediatric solid tumors acculturation and dental service use among asian immigrants in the u.s disparities found between asian immigrants sufficient access and utilization of dental services mixed handedness is linked to mental health problems in children and adolescents mixed handed children more likely to have mental health language and scholastic problems study finds outpatient versus inpatient treatment for patients with acute pulmonary embolism an international open label randomised non inferiority trial outpatient treatment proves safe effective for low risk patients with pulmonary embolism study suggests stim controls t cell mediated immune regulation and inflammation in chronic infection unexpected role for calcium in controlling inflammation during chronic lung infection hidden in plain sight a remarkable new genus of nearctic treehoppers hemiptera membracidae new genus of treehopper named after selena quintanilla the queen of tejano music seismic slip on an upper plate normal fault during a large subduction megathrust rupture discovery of hidden earthquake presents challenge to earthquake early warning systems causes and timing of death in extremely premature infants from through deaths of extremely premature infants decrease fewer dying of breathing complications water on the surface of the moon as seen by the moon mineralogy mapper distribution abundance and origins first global map of water in moon s soil hypoxia induced neonatal seizures diminish silent synapses and long term potentiation in hippocampal ca neurons dodging the cognitive hit of early life seizures aberrant level of mirnas in bone marrow microenvironment and peripheral blood of myeloma patients and disease progression study lays groundwork for blood test to aid in the detection and monitoring of myeloma glycans modify mesenchymal stem cell differentiation to impact the function of resulting osteoblasts could sugar chains be the answer to bone growth in osteoporosis ? melanocyte keratinocyte transplantation procedure in the treatment of vitiligo the experience of an academic medical center in the united states skin transplant offers new hope for vitiligo patients activating a reserve neural stem cell population in vitro enables engraftment and multipotency after transplantation cultured stem cells reconstruct sensory nerve and tissue structure in the nose multiple murine brafv emelanoma cell lines with sensitivity to plx protocol developed to harvest mouse cell lines for melanoma research the geochemistry of don juan pond evidence for a deep groundwater flow system in wright valley antarctica salt pond in antarctica among the saltiest waters on earth is fed from beneath connecting the dots a correlation between ionising radiation and cloud mass loss rate traced by optical integral field spectroscopy pillars of cosmic destruction colorful carina nebula blasted by brilliant nearby stars symptoms of knee instability are risk factors for recurrent falls treatments that reduce knee buckling may help prevent falls in older adults long term use of aspirin and age related macular degeneration regular aspirin use or more years ago associated with increased risk of type of age related macular degeneration larval dispersal connects fish populations in a network of marine protected areas connectivity in marine fish populations larvae spawned in marine reserves can travel long distances modulated continuous wave control for energy efficient electron nuclear spin coupling quantum sensors providing magnetic resonance with unprecedented sensitivity adherence to high intensity statins following a myocardial infarction hospitalization among medicare beneficiaries adherence to high intensity statin drops off for many following heart attack influenza surveillance h n swine derived influenza viruses from india swine flu outbreak in india raises concern new strain of h n may carry dangerous mutations off target lapatinib activity sensitizes colon cancer cells through trail death receptor up regulation breast cancer drug pushes colon cancer cells to their death association of ectomycorrhizal trees with high carbon to nitrogen ratio soils across temperate forests is driven by smaller nitrogen not larger carbon stocks soil fungi may help determine the resilience of forests to environmental change demonstration of improved tissue integration and angiogenesis with an elastic estradiol releasing polyurethane material designed for use in pelvic floor repair new vaginal mesh material could help thousands of women affected by life changing complications child parent psychotherapy with infants hospitalized in the neonatal intensive care unit integrating infant mental health into the neonatal intensive care unit breast cancer cells condition lymphatic endothelial cells within pre metastatic niches to promote metastasis prepped by tumor cells lymphatic cells encourage breast cancer cells to spread broadening reef protection across the marine conservation corridor of the eastern tropical pacific distribution and diversity of reefs in las perlas archipelago panama smithsonian coral biodiversity survey of panama s pearl islands designing bioinspired surfaces for water collection from fog collecting clean water from air inspired by desert life cell host response to infection with novel human coronavirus emc predicts potential antivirals and important differences with sars coronavirus tactics of new middle east virus suggest treating by altering lung cells response to infection tumor cell derived periostin regulates cytokines that maintain breast cancer stem cells new breast cancer stem cell clues may help develop therapeutics tdp stage mixed pathologies and clinical alzheimer s type dementia abnormal brain protein may contribute to alzheimer s disease development differing pathways between religiousness spirituality and health a self regulation perspective. religion spirituality influence health in different but complementary ways the assessment of water use and reuse through reported data a us case study study reveals need for better understanding of water use a global map of the protein shape universe creating a global map of the protein shape universe high throughput nano biofilm microarray for antifungal drug discovery new palm sized microarray technique grows individual cultures of microbes photogrammetry of killer whales using a small hexacopter launched at sea studying killer whales with an unmanned aerial vehicle effect of endurance exercise on micrornas in myositis skeletal muscle a randomized controlled study endurance training helpful in recovery from muscle inflammation new study shows a taxonomic study of the genus panesthia blattodea blaberidae panesthiinae from china with descriptions of one new species one new subspecies and the male of panesthia antennata hermit creepy crawlies two new taxa of wood feeding cockroach from china mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the predimed trial mediterranean diet plus olive oil associated with reduced breast cancer risk a biosynthetic strategy for re engineering thestaphylococcus aureuscell wall with non native small molecules scientists trick bacteria into embedding small molecules in cell wall mecp binds to hmc enriched within active genes and accessible chromatin in the nervous system a little tag with a large effect how the epigenetic marker hydroxymethylcytosine is interpreted by neural cells a upf b mutant mouse model with behavioral and neurogenesis defects new mouse model replicates an underlying cause of intellectual disability clinical characterization of in vivo inflammatory bowel disease with raman spectroscopy new sensor integrates inflammatory bowel disease detection into colonoscopy procedure turning the tide on trash empowering european educators and school students to tackle marine litter enhanced education could help turn the tide on marine litter gender differences in the associations between age trends of social media interaction and well being among year olds in the uk social media use at age could reduce wellbeing of adolescent girls traumatic brain injury and olfactory deficits the tale of two smell tests ! traumatic brain injury causes loss of smell and taste maternal overweight and obesity in early pregnancy and risk of infant mortality a population based cohort study in sweden overweight and obesity in pregnancy linked to greater risk of infant death molecular classification of crohn s disease reveals two clinically relevant subtypes two distinct genetic subtypes found in crohn s disease patients diverse coral communities in naturally acidified waters of a western pacific reef coral reefs in palau surprisingly resistant to naturally acidified waters randomized controlled trial of an intervention for toddlers with autism the early start denver model early intervention for toddlers with autism highly effective study finds non invasive force measurement reveals the number of active kinesins on a synaptic vesicle precursor in axonal transport regulated by arl multiple ant like transport of neuronal cargo by motor proteins youth access to artificial uv radiation exposure practices of us indoor tanning facilities nationwide study examines youth access to indoor tanning tomato yield heterosis is triggered by a dosage sensitivity of the florigen pathway that fine tunes shoot architecture genetic discovery points to bigger yields in tomato other flowering food plants decreasing maternal myostatin programs adult offspring bone strength in a mouse model of osteogenesis imperfecta protein in womb plays lifelong role in bone health study of mice shows geographical imbalances and divides in the scientific production of climate change knowledge the most vulnerable countries miss out on climate change knowledge does the imprecise definition of overactive bladder serve commercial rather than patient interests ? concept of overactive bladder serves commercial interests rather than patient interests experts say social influence on year survival in a longitudinal chemotherapy ward co presence network social interaction affects cancer patients response to treatment efficacy of educational video game versus traditional educational apps at improving physician decision making in trauma triage randomized controlled trial video game improves doctors recognition and triage of severe trauma patients robotic plasma probe ionization mass spectrometry roppi ms of non planar surfaces robotic arm probes chemistry of d objects by mass spectrometry a brief botanical survey into kumbira forest an isolated patch of guineo congolian biome botanical diversity unraveled in a previously understudied forest in angola prevalence incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness a large scale meta analysis of patients and controls severe mental illness linked to much higher risk for cardiovascular disease an artificial pathway for isoprenoid biosynthesis decoupled from native hemiterpene metabolism researchers create shortcut to terpene biosynthesis in e. coli a decision support system to assist the sustainable management of navigation activities in the st. lawrence river estuary canada new computer program promises to save the whales intrabody gene therapy ameliorates motor cognitive and neuropathological symptoms in multiple mouse models of huntington s disease gene therapy stalls development of huntington s disease in mice successful month bangladesh regimen for multidrug resistant tuberculosis among over consecutive patients successful short treatment against drug resistant tuberculosis confirmed a mirna a nfat axis links impaired t cell tolerance induction with autoimmune type diabetes type diabetes autoimmune reaction successfully halted in early stage islet autoimmunity rare species support vulnerable functions in high diversity ecosystems rare species perform unique roles even in diverse ecosystems health status sexual activity and satisfaction among older people in britain a mixed methods study sexual satisfaction among older people about more than just health a translational pharmacology approach to predicting hiv pre exposure prophylaxis outcomes in men and women using tenofovir disoproxil fumarate emtricitabine women need more of the hiv drug truvada than men to prevent infection in silico modeling predicts drug sensitivity of patient derived cancer cells cancer avatars for personalized medicine help researchers find genomic signatures of cancers anesthesia induced neuronal apoptosis in the developing retina looking at retinal cells may provide new approach to assessing anesthetic neurotoxicity in children temporal overlap of humans and giant lizards varanidae squamata in pleistocene australia giant killer lizard fossil shines new light on early australians differential climate impacts for policy relevant limits to global warming the case of. deg c and deg c . c vs c global warming new study shows why half a degree matters microbial community transcriptional networks are conserved in three domains at ocean basin scales oceanic microbes behave in a synchrony across ocean basins living and conducting coating individual bacterial cells with in situ formed polypyrrole coating bacteria with electron conducting polymer for microbial fuel cells child obesity associated with social disadvantage of children s neighborhoods childhood obesity linked to neighborhood social and economic status study finds effect of intensive vs standard blood pressure control on probable dementia lowering blood pressure reduces risk of cognitive impairment aspirin reduces plasma concentrations of the oncometabolite hydroxyglutarate results of a randomized double blind crossover trial possible new mechanism for aspirin s role in cancer prevention modulation of catenin function maintains mouse epiblast stem cell and human embryonic stem cell self renewal researcher reveals how to better master stem cells fate variation in the cost of radiation therapy among medicare patients with cancer radiation costs vary among medicare patients with cancer experienced migratory bats integrate the sun s position at dusk for navigation at night compass orientation of a migratory bat species depends on sunset direction honey bee workers that are pollen stressed as larvae become poor foragers and waggle dancers as adults poor nutrition for honey bee larvae compromises pollination capabilities as adults search for domain wall dark matter with atomic clocks on board global positioning system satellites one step closer to defining dark matter gps satellite atomic clocks on the hunt pediatric injuries associated with high chairs and chairs in the united states children a day treated in u.s. ers for high chair related injuries are stem cell based therapies for parkinson s disease ready for the clinic in ? are stem cell therapies for parkinson s disease ready for clinical trials ? photodetachment dynamics of negative ions near a moving surface electron gun simulations explain the mechanisms of high energy cosmic rays low dose suramin in autism spectrum disorder a small phase i ii randomized clinical trial century old drug as potential new approach to autism an antimicrobial peptide essential for bacterial survival in the nitrogen fixing symbiosis harnessing a peptide holds promise for increasing crop yields without more fertilizer spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders new map may lead to drug development for complex brain disorders researcher says antibiotic prescription rates for acute respiratory tract infections in us ambulatory settings overall antibiotic prescription rates for respiratory tract infections decreasing emotions experienced during the shedding of the first primary tooth loss of first baby tooth a positive experience for children the emergence of network inefficiencies in infants with autism spectrum disorder origins of autism abnormalities in sensory processing at six months elimination of hiv in south africa through expanded access to antiretroviral therapy a model comparison study hiv elimination in south africa could be achieved by current treatment policy association of cerebral palsy with apgar score in low and normal birthweight infants population based cohort study low apgar score at birth linked to cerebral palsy ants show a leftward turning bias when exploring unknown nest sites ants show left bias when exploring new spaces wetland carbon storage controlled by millennial scale variation in relative sea level rise as sea level rises wetlands crank up their carbon storage phosphodiesterase type inhibitors and risk of malignant melanoma matched cohort study using primary care data from the uk clinical practice research datalink taking pde inhibitors for erectile dysfunction unlikely to increase risk of skin cancer assessing predictions of population viability analysis peregrine falcon populations in california volunteer eyes on the skies track peregrine falcon recovery in california addressing the nation s physician workforce needs the society of general internal medicine sgim recommendations on graduate medical education reform addressing physician shortage recommendations for medical education reform the natural history of molecular functions inferred from an extensive phylogenomic analysis of gene ontology data new study sheds light on origins of life on earth through molecular function influence of motion picture rating on adolescent response to movie smoking rating films with smoking r will cut smoking onset by teens experts say bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise fat of the bone exercise diabetes affect amount of fat inside bones biosurfactants change the thinning of contaminated bubbles at bacteria laden water interfaces bursting bubbles launch bacteria from water to air geodetic evidence that mercury has a solid inner core mercury has a solid inner core new evidence cryptic female choice favours sperm from mhc dissimilar males promiscuity and sperm selection improves genetic quality in birds antiretroviral treatment for children with peripartum nevirapine exposure hiv aids promising results from infant treatment with protease inhibitor lopinavir lpv r study suggests microrna targets the vitamin d dependent antimicrobial pathway in leprosy stealthy leprosy pathogen evades critical vitamin d dependent immune response towards clinical application of pronuclear transfer to prevent mitochondrial dna disease new safety efficacy evidence for mitochondrial donation revealed gene expression differences between ruptured anterior cruciate ligaments in young male and female subjects acl injuries in female athletes traced to genes akawaio penak a new genus and species of neotropical electric fish gymnotiformes hypopomidae endemic to the upper mazaruni river in the guiana shield new genus of electric fish discovered in lost world of south america factors influencing high school coaches adoption of injury prevention programs injury prevention programs not widely used in high school sequences flanking the core binding site modulate glucocorticoid receptor structure and activity dna structure influences the function of transcription factors two weeks of high intensity interval training improves novel but not traditional cardiovascular disease risk factors in adolescents short intense exercise bursts can reduce heart risk to teens anopheles gambiaeblood feeding initiates an anticipatory defense response toplasmodium berghei mosquitoes ramp up immune defenses after sucking blood vet researcher finds fragment derived inhibitors of human n myristoyltransferase block capsid assembly and replication of the common cold virus molecule that acts on human cells might provide hope for irresistible cold cure nonobstructive coronary artery disease and risk of myocardial infarction nonobstructive coronary artery disease associated with increased risk of heart attack death depressive symptoms and the buffering effect of resilience on widowhood by gender low resilience puts men at risk for depression training humans to categorize monkey calls auditory feature and category selective neural tuning changes brain processes sight and sound in same manner inhibition of brain tumor growth by intravenous poly l malic acid nanobioconjugate with ph dependent drug release nano drug hits brain tumor target unique triggering device delivers antitumor drugs prevention of nonvertebral fractures with oral vitamin d and dose dependency a meta analysis of randomized controlled trials vitamin d supplements associated with reduced fracture risk in older adults cellular clearance of circulating transthyretin decreases cell nonautonomous proteotoxicity incaenorhabditis elegans new model of a peripheral nervous system disease structural cause of a missed eruption in the harrat lunayyir basaltic field saudi arabia in origins of red sea s mysterious cannon earthquakes revealed mutations in microrna processing genes in wilms tumors derepress the igf regulator plag scientists identify new mechanisms underlying pediatric kidney cancer autophagy variation within a cell population determines cell fate through selective degradation of fap study autophagy predicts which cancer cells live die when faced with anti cancer drugs a solar cycle correlation of coronal element abundances in sun as a star observations solving the mystery of the sun s hot atmosphere arsenic exposure from drinking water and mortality from cardiovascular disease in bangladesh prospective cohort study cigarette smoking and arsenic exposure a deadly combination biophysical constraints to potential production capacity of potato across the u.s. eastern seaboard region food security increased by new scientific model in agricultural production prognostic value of intrinsic subtypes in hormone receptor positive metastatic breast cancer treated with letrozole with or without lapatinib intrinsic subtyping enables fine tuned prognosis prediction of tumor behavior a low fodmap diet improves quality of life reduces activity impairment and improves sleep quality in patients with irritable bowel syndrome and diarrhea results from a u.s. randomized controlled trial clinical trial demonstrates success of low fodmap diet thermal limit for metazoan life in question in vivo heat tolerance of the pompeii worm thermal limit for animal life redefined by first lab study of deep sea vent worms ebola virus neutralizing antibodies detectable in survivors of theyambuku zaire outbreak years after infection forty years after first ebola outbreak survivors show signs they can stave off new infection international osteoporosis foundation and european calcified tissue society working group. recommendations for the screening of adherence to oral bisphosphonates bone markers as screening strategy for patient adherence to osteoporosis medications short term benefits but transgenerational costs of maternal loss in an insect with facultative maternal care earwigs raised without parents demonstrate limited maternal care of their own offspring sik inhibition in human myeloid cells modulates tlr and il r signaling and induces an anti inflammatory phenotype salt inducible kinases may have therapeutic potential for autoimmune diseases the impact of skills training on responses to the disclosure of mistreatment. skills training can improve responses to disclosures of trauma coffee decaffeinated coffee and tea consumption in relation to incident type diabetes mellitus a systematic review with meta analysis drinking coffee decaf and tea regularly associated with a reduced risk of diabetes patterns of social emotional needs and trajectories of aggression and substance use among middle school boys boys with social difficulties most susceptible to early substance use comparative metatranscriptomics reveals kingdom level changes in the rhizosphere microbiome of plants why crop rotation works change in crop species causes shift in soil microbes footprint of deepwater horizon blowout impact to deep water coral communities impact of deepwater horizon oil spill on coral is deeper and broader than predicted effect of water content on the glass transition temperature of mixtures of sugars polymers and penetrating cryoprotectants in physiological buffer study sheds light on alternative more convenient method of cell preservation opposing effects of fasting metabolism on tissue tolerance in bacterial and viral inflammation listening to the body study examines the effects of fasting on infections screening outcomes in older us women undergoing multiple mammograms in community practice does interval age or comorbidity score affect tumor characteristics or false positive rates ? mammogram every two years has same benefit as yearly mammogram for older women study finds urine sample derived human induced pluripotent stem cells as a model to study pcsk mediated autosomal dominant hypercholesterolemia urine derived stem cells predict patient response to cholesterol lowering drugs liver directed lentiviral gene therapy in a dog model of hemophilia b new gene therapy for hemophilia shows potential as safe treatment evidence for repeated independent evolution of migration in the largest family of bats to the bat cave researchers reconstruct evolution of bat migration with aid of mathematical model effectiveness of personalised risk information and taster sessions to increase the uptake of smoking cessation services start quit a randomised controlled trial offering a stop smoking taster session and personalized disease risk doubles likelihood smokers will seek help to quit ocean currents modify the coupling between climate change and biogeographical shifts going with the flow the forces that affect species movements in a changing climate skin parasite landscape determines host infectiousness in visceral leishmaniasis skin plays significant role in spread of leishmaniasis chronic subthreshold cortical stimulation to treat focal epilepsy continuous electrical brain stimulation helps patients with epilepsy interactive effects of physical fitness and body mass index on the risk of hypertension high bmi low aerobic capacity in late teens linked with hypertension in adults firearm violence among high risk emergency department youth after an assault injury young guns high rate of firearm violence found in high risk youth after assault injury the role of congruency in retronasal odor referral to the mouth a trained palate understanding complexities of taste smell could lead to improved diet the sphingosine kinase survival pathway is a molecular target for the tumor suppressive tea and wine polyphenols in prostate cancer polyphenols in red wine and green tea halt prostate cancer growth study suggests organized sport participation from childhood to adolescence is associated with bone mass in young adults from the raine study participating in sports during childhood may have long term benefits for bone health plasticity driven individualization of olfactory coding in mushroom body output neurons approach or buzz off brain cells in fruit fly hold secret to individual odor preferences a pilot randomized clinical trial testing integrated twelve step facilitation itsf treatment for adolescent substance use disorder incorporating step program elements improves youth substance use disorder treatment disruption of tet promotes the therapeutic efficacy of cd targeted t cells cll patient goes into remission thanks to single car t cell rare tp genetic variant associated with glioma risk and outcome activity of rare genetic variant in glioma validated novel atypical pkc inhibitors prevent vascular endothelial growth factor induced blood retinal barrier dysfunction novel therapy may prevent damage to the retina in diabetic eye diseases national and state level impact and cost effectiveness of nonavalent hpv vaccination in the united states new hpv vaccine could curb cervical cancers and health costs if adopted widely mussel inspired defect engineering of graphene liquid crystalline fibers for synergistic enhancement of mechanical strength and electrical conductivity mussel inspired defect engineering enhances the mechanical strength of graphene fibers association between birth in a high stroke mortality state race and risk of dementia higher dementia risk associated with birth in high stroke mortality states stroke survivors over estimate their medication self administration msa ability predicting memory loss stroke researchers link ability to self administer medication with memory loss the control of hiv after antiretroviral medication pause champ study post treatment controllers identified from clinical studies largest study of post treatment controllers reveals clues about hiv remission how global warming changes the difficulty of synoptic weather forecasting climate changes make some aspects of weather forecasting increasingly difficult mortality in the united states from self injury surpasses diabetes a prevention imperative call for a unified approach to preventing suicides and other self injury deaths therapeutic efficacy of the small molecule gs against ebola virus in rhesus monkeys novel small molecule antiviral compound protects monkeys from deadly ebola virus male scientists competing devotions to work and family changing norms in a male dominated profession some male scientists willing to forsake careers for family dissemination of misinformative and biased information about prostate cancer on youtube reliance on youtube medicine may be dangerous for those concerned about prostate cancer multiple molecular subtypes of triple negative breast cancer critically rely on androgen receptor and respond to enzalutamide in vivo in triple negative breast cancer even low androgen tumors respond to anti androgen therapy use of antidementia drugs and risk of pneumonia in older persons with alzheimer s disease among antidementia drugs memantine is associated with the highest risk of pneumonia a model balancing cooperation and competition can explain our right handed world and the dominance of left handed athletes shedding light on southpaws sports data help confirm theory explaining left handed minority in general population limited contribution of ancient methane to surface waters of the u.s. beaufort sea shelf release of ancient methane due to changing climate kept in check by ocean waters out with old growth in with ecological continnewity new perspectives on forest conservation rethinking old growth forests using lichens as an indicator of conservation value tau reduction prevents disease in a mouse model of dravet syndrome reduction of tau protein improves symptoms in model of severe childhood epilepsy a systematic review and meta analysis of on road simulator and cognitive driving assessment in alzheimer s disease and mild cognitive impairment driving ability of people with cognitive impairment difficult to assess research review australian shelf sediments reveal shifts in miocene southern hemisphere westerlies shelf sediments reveal climate shifts through the eons long term integrated studies show complex and surprising effects of climate change in northern hardwood forests long term research reveals how climate change is playing out in real ecosystems anomalously weak labrador sea convection and atlantic overturning during the past years atlantic ocean circulation at weakest point in years effect of personalized nutrition on health related behaviour change evidence from the food me european randomized controlled trial personalized nutrition is better than a one size fits all approach in improving diets molecular detection of human h n influenza a virus causing outbreaks in china new test for h n bird flu in china may help slow outbreak prevent pandemic revised methane emissions factors and spatially distributed annual carbon fluxes for global livestock global methane emissions from agriculture larger than reported according to new estimates retrotransposon activation contributes to neurodegeneration in a drosophila tdp model of als research suggests a possible role for a storm of jumping genes in als what causes radiation belt enhancements a survey of the van allen probes era the case of the relativistic particles solved with nasa missions sexual dimorphism in the behavioral responses and the immuno endocrine status in d galactose induced aging d galactose affects ageing male and female brains differently evolutionary loss of cone photoreception in balaenid whales reveals circuit stability in the mammalian retina genetic mutation in whale eyes may increase mortality risks impact of a web portal intervention on community adhd care and outcomes web based technology improves pediatric adhd care and patient outcomes diagnosis of zika virus infection by peptide array and enzyme linked immunosorbent assay new test extends window for accurate detection of zika biodiversity conservation and poverty traps special feature lessons about parks and poverty from a decade of forest loss and economic growth around kibale national park uganda poverty and national parks decade long study finds surprising relationship cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell derived cardiovascular cells challenges of custom engineering living tissue to fix a heart key taxa in food web responses to stressors the deepwater horizon oil spill after deepwater horizon spill which animals weathered the disaster differential mental health effects of neighborhood relocation among youth in vulnerable families results from a randomized trial moving from high poverty to low poverty neighborhoods appears beneficial for some adolescent girls in vitro and in vivo characterization of new swine origin h n influenza viruses swine flu h n virus more dangerous than suspected except to survivors of the pandemic flu virus electrophoretic nuclei assembly for crystallization of high performance membranes on unmodified supports metal organic frameworks cut energy consumption of petrochemicals choosing wisely ? measuring the burden of medications in older adults near the end of life nationwide longitudinal cohort study patient often prescribed potentially futile drugs in their final months of life gene therapy restores auditory and vestibular function in a mouse model of usher syndrome type c gene therapy restores hearing in deaf mice down to a whisper detection and characterization of the first north american mastrevirus in switchgrass first report of a new crop virus in north america a cluster randomized trial to provide clinicians inhaled corticosteroid adherence information for their patients with asthma getting patients to take their asthma meds physicians can play stronger role study says highly fluorinated chemicals in functional textiles can be replaced by re evaluating liquid repellency and end user requirements research into outdoor and protective clothing seeks to shake off fluorochemicals regulation of meristem morphogenesis by cell wall synthases in arabidopsis plant cell wall development revealed in space and time for the first time metabolomic profiles delineate potential role for sarcosine in prostate cancer progression molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment reduced bone density and vertebral fractures in smokers men and copd patients at increased risk male smokers at higher risk than females for osteoporosis fractures football related injuries among to year olds treated in us emergency departments increase in football related injuries among youth found in new u.s. study the genetic intersection of neurodevelopmental disorders and shared medical comorbidities relations that translate from bench to bedside genetic intersection of neurodevelopmental disorders shared medical conditions novel pedigree analysis implicates dna repair and chromatin remodeling in multiple myeloma risk changes in genes involved in dna repair and packaging linked to risk of multiple myeloma radar tracking and motion sensitive cameras on flowers reveal the development of pollinator multi destination routes over large spatial scales how bumblebees find efficient routes without a gps bees use trial and error to select optimal route intersecting residential and transportation co emissions metropolitan climate change programs in the age of trump to drop carbon dioxide emissions look to local transportation and housing transforaminal endoscopic surgery under local analgesia for ventral epidural thoracic spinal tumor case report endoscopic removal of spinal tumor with the patient awake reported syringomyelia determining risk and protective factors in the conformation of the cavalier king charles spaniel dog skull shape risk factors could help in welfare of toy dog breeds role of astroglia in down s syndrome revealed by patient derived human induced pluripotent stem cells support cells in brain play important role in down syndrome characteristics and prognosis in women and men with type diabetes undergoing coronary angiography a nationwide registry report being female is not a protective factor against heart disease in type diabetes lentivirus mediated expression of cdna and shrna slows degeneration in retinitis pigmentosa cell specific mechanism based gene therapy approach to treat retinitis pigmentosa emotion regulation in obsessive compulsive disorder unaffected siblings and unrelated healthy control participants people with ocd process emotions differently than their unaffected siblings spray applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers a phase multicentre double blind randomised placebo controlled trial higher healing rate using unique cell based therapy in chronic venous leg ulcers local triple combination therapy results in tumour regression and prevents recurrence in a colon cancer model patch delivers drug gene and light based therapy to tumor sites innovative collagen nano hydroxyapatite scaffolds offer a highly efficient non viral gene delivery platform for stem cell mediated bone formation regenerating bone tissue using gene therapy new method may work with other tissues as well efficacy of a prevention program for postpartum obsessive compulsive symptoms psychologists develop successful prevention program for postpartum ocd alarming prevalence of emergency hypertension levels in the general public identified by a hypertension awareness campaign alarming levels of hypertension found in the general public groundwater sapping as the cause of irreversible desertification of hunshandake sandy lands inner mongolia northern china first ever evidence of drastic climate change of northern china region years ago favorable long term outcome of patients with multiple myeloma using a frontline tandem approach with autologous and non myeloablative allogeneic transplantation cancer treatment therapeutic approach gives hope for the treatment of multiple myeloma sleep disorders and associated medical comorbidities in active duty military personnel active duty military personnel prone to sleep disorders and short sleep duration best interests in paediatric intensive care an empirical ethics study cystic fibrosis study offers new understanding of silent changes in genes a national assessment of stressors to estuarine fish habitats in the contiguous usa project serves up big data to guide managing america s coastal waters physical properties of particulate matter from animal houses empirical studies to improve emission modelling dust particles in livestock facilities sweat the small stuff autonomous multi joint soft exosuit with augmentation power based control parameter tuning reduces energy cost of loaded walking multi joint personalized soft exosuit breaks new ground distinct functions for wnt catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis activating pathway could restart hair growth in dormant hair follicles elevated intrinsic cancer stem cell population in human papillomavirus associated head and neck squamous cell carcinoma number of cancer stem cells might not predict outcome in hpv related oral cancers international reach of tobacco marketing among young children young children recognize cigarette brands in countries with most smokers generation of three dimensional retinal tissue with functional photoreceptors from human ipscs human stem cells used to create light sensitive retina in a dish polymeric nanoparticles for nonviral gene therapy extend brain tumor survivalin vivo gene therapy advance thwarts brain cancer in rats math anxiety and exposure to statistics in messages about genetically modified foods effects of numeracy math self efficacy and form of presentation math anxiety factors into understanding genetically modified food messages exposure to bovine leukemia virus is associated with breast cancer a case control study virus in cattle linked to human breast cancer post glacial colonization of western europe brown bears from a cryptic atlantic refugium out of the iberian peninsula the iberian brown bears do not descend from those fled from the north during the ice age rapamycin prevents seizures after depletion of strada in a rare neurodevelopmental disorder intractable seizures halted with experimental treatment for rare pediatric pretzel syndrome performance of the genexpert ebola assay for diagnosis of ebola virus disease in sierra leone a field evaluation study automated ebola blood test performs well in field evaluation is seeing gesture necessary to gesture like a native speaker ? seeing isn t required to gesture like a native speaker microfluidic differential immunocapture biochip for specific leukocyte counting differential immuno capture biochip offers specific leukocyte counting for hiv diagnosis insurance related barriers to accessing dental care among african american adults with oral health symptoms in harlem new york city why disparities in dental care persist for african americans even when they have insurance coverage taming the complexity of donor acceptor stenhouse adducts infrared motion pictures of the complete switching pathway novel molecular multi step photoswitches caught in the act new medicines for tropical diseases in pregnancy catch better treatments for malaria in pregnancy are needed early cave art and ancient dna record the origin of european bison mystery species hidden in cave art appears to be unknown bison cattle hybrid adverse outcomes associated with cigarette smoke radicals related to damage to protein disulfide isomerase new clues to copd linked to proteostasis imbalance caused by cigarette smoke stimulation of hiv specific cytolytic t lymphocytes facilitates elimination of latent viral reservoir after virus reactivation vaccination strategy may hold key to ridding hiv infection from immune system early and longitudinal microglial activation but not amyloid accumulation predicts cognitive outcome in ps app mice new pet imaging biomarker could better predict progression of alzheimer s disease quantifying global soil carbon losses in response to warming losses of soil carbon under global warming might equal us emissions men s sexual response to female partner s intranasal oxytocin administration for hypoactive sexual desire disorder an open prospective cohort study sexual satisfaction treating a woman with oxytocin also benefits her male partner temperature mediates continental scale diversity of microbes in forest soils study on diversity of microbial groups demonstrates the effects of human caused changes in climate land use and other factors ignoring children s emotions a novel ignoring subscale for the coping with children s negative emotions scale revised measure provides means to assess parents ignoring of children s emotions social media s enduring effect on adolescent life satisfaction social media has limited effects on teenage life satisfaction homologous recombination mediates functional recovery of dysferlin deficiency following aav gene transfer new gene transfer strategy shows promise for limb girdle and other muscular dystrophies shave biopsy is a safe and accurate method for the initial evaluation of melanoma shave biopsy is a safe and acceptable method for initial evaluation of melanoma study suggests sneeze to leave african wild dogs lycaon pictus use variable quorum thresholds facilitated by sneezes in collective decisions something to sneeze about democratic voting in african wild dog packs coal chemicals china s high carbon clean coal programme ? high carbon coal products could derail china s clean energy efforts epidemiology and impact of health care provider diagnosed anxiety and depression among us children more than in us children and teens have anxiety or depression effect of soil amendments on cd accumulation by spinach from a cd mineralized soil soil amendments for healthier spinach combo of biosolids zinc limestone prevents toxic uptake associations of initial injury severity and posttraumatic stress disorder diagnoses with long term hypertension risk after combat injury severe war injuries and ptsd can impact hypertension risk medial temporal lobe structures and hippocampal subfields in psychotic disorders reduction in volume in hippocampus region of brain seen in psychotic disorders trends in the treatment of metastatic colon and rectal cancer in elderly patients high side effects high cost one month gain in percent of elderly metastatic colorectal cancer patients medieval women s early involvement in manuscript production suggested by lapis lazuli identification in dental calculus illuminating women s role in the creation of medieval manuscripts updating the supermassive black hole mass spiral arm pitch angle relation a strong correlation for galaxies with pseudobulges spiral arms allow school children to weigh black holes when where and what ? characterizing personal pm. exposure in periurban india by integrating gps wearable camera and ambient and personal monitoring data the when where and what of air pollutant exposure effect of high dose folic acid supplementation in pregnancy on pre eclampsia fact double blind phase iii randomised controlled international multicentre trial high dose folic acid does not prevent pre eclampsia in high risk women recommendations for the establishment of stroke systems of care a update a policy statement from the american stroke association new recommendations for stroke systems of care to improve patient outcomes eco hab as a fully automated and ecologically relevant assessment of social impairments in mouse models of autism eco hab new quality in research on neuronal basis of social behavior drug use in persons with and without alzheimer s disease aged years or more more than half of persons with alzheimer s disease aged years or more use psychotropic drugs phosphodiesterase inhibition reduces postoperative metastatic disease by targeting surgery induced myeloid derived suppressor cell dependent inhibition of natural killer cell cytotoxicity erectile dysfunction drugs and flu vaccine may work together to help immune system fight cancer after surgery a robust data driven approach identifies four personality types across four large data sets scientists determine four personality types based on new data poppers legal highs with questionable contents ? a case series of poppers maculopathy new chemical composition of poppers linked to retinal damage generic medication prescription rates after health system wide redesign of default options within the electronic health record changing default prescription settings in emrs increased rates of generic drugs study finds evolutionary history of saber toothed cats based on ancient mitogenomics ancient dna offers new view on saber toothed cats past statin therapy and risk of acute memory impairment study examines association between cholesterol lowering drugs memory impairment altered proliferation and networks in neural cells derived from idiopathic autistic individuals scientists uncover common cell signaling pathway awry in some types of autism scam awareness related to incident alzheimer dementia and mild cognitive impairment low scam awareness in old age may be an early sign of impending cognitive decline and dementia occupational factors and markers of ovarian reserve and response among women at a fertility centre physically demanding jobs and shiftwork linked to lowered fertility in women taxes and subsidies for improving diet and population health in australia a cost effectiveness modelling study sugar salt and fat taxes could save billions in health care costs age related effects and sex differences in gray matter density volume mass and cortical thickness from childhood to young adulthood gray matter density increases during adolescence study finds physician burnout well being and work unit safety grades in relationship to reported medical errors medical errors may stem more from physician burnout than unsafe health care settings the asparagus genome sheds light on the origin and evolution of a young y chromosome key to better asparagus identified in evolution of sex chromosomes negative perceptions of aging modify the association between frailty and cognitive function in older adults attitude to aging can have a direct effect on health researchers confirm pax expression defines germline stem cells in the adult testis rare stem cells hold potential for infertility treatments phosphate incorporation during glycogen synthesis and lafora disease discovery of source of glycogen manufacturing errors sheds light on fatal disease integrated conversion of cellulose to high density aviation fuel plant scraps are the key ingredient in cheap sustainable jet fuel river restoration by dam removal enhancing connectivity at watershed scales removal of dams in new england can help reconnect river networks nonenzymatic biomimetic remodeling of phospholipids in synthetic liposomes synthetic membranes created to mimic properties of living cells development of the annelid axochord insights into notochord evolution from worm muscle to spinal discs an evolutionary surprise metastatic ovarian cancer cell malignancy is increased on soft matrices through a mechanosensitive rho rock pathway ovarian cancer cells more aggressive on soft tissues association between excessive bmi increase during puberty and risk of cardiovascular mortality in adult men a population based cohort study excessive bmi increase during puberty identified as a new risk factor for mortality due to cardiovascular disease a centre triggered magnesium fuelled cathodic arc thruster uses sublimation to deliver a record high specific impulse rocket return journey to mars closer with engine s record efficiency effects of school composition and school climate on teacher expectations of students a multilevel analysis school environment affects teacher expectations of their students violent and nonviolent suicide in veterans with substance use disorders violence not overdose the likely method of suicide in veterans with substance use disorders built environment associates of active school travel in new zealand children and youth a systematic meta analysis using individual participant data new zealand s secret recipe for active school travel the neighborhood built environment sentinel lymph node biopsy for patients with early stage breast cancer american society of clinical oncology clinical practice guideline update breast cancer update sentinel node biopsy guidelines encourage less is more approach estrogen plus progestin and breast cancer incidence and mortality in the women s health initiative observational study estrogen plus progestin use linked with increased breast cancer incidence and mortality us public support for drone strikes against asymmetric enemies abroad poll trends in new research questions effectiveness of drones in fight against terrorism and highlights growing opposition to their use ion channel trpv dependent activation of ptp b suppresses egfr associated intestinal tumorigenesis chili peppers for a healthy gut spicy chemical may inhibit gut tumors excessive transforming growth factor signaling is a common mechanism in osteogenesis imperfecta new approach to treating brittle bone disease unveiled pretreatment health behaviors predict survival among patients with head and neck squamous cell carcinoma cancer survival pretreatment alcohol tobacco fruit exercise habits linked to head and neck cancer survival contribution of secreted nadase and streptolysin o to the pathogenesis of epidemic serotype m streptococcus pyogenes infections cytotoxins contribute to virulence of deadly epidemic bacterial infections garp accelerates retinal degeneration in rod cgmp gated cation channel subunit knockout mice garp accelerates retinal degeneration in a mouse model comparison of vitamin d and vitamin d supplementation in raising serum hydroxyvitamin d status a systematic review and meta analysis health benefits of vitamin d dependent on type taken socioeconomic determinants of disability and depression in patients with rheumatoid arthritis low socioeconomic status increases depression risk in rheumatoid arthritis patients the impact of adverse childhood experiences on an urban pediatric population childhood trauma linked to higher rates of mental health problems risk of cancer among workers exposed to trichloroethylene analysis of three nordic cohort studies tce exposure linked to increased risk of some cancers maternal and infant outcomes associated with lithium use in pregnancy an international collaborative meta analysis of six cohort studies increased risk of birth defects in babies after first trimester exposure to lithium tumor sequencing and patient derived xenografts in the neoadjuvant treatment of breast cancer new critical information on tumor sequencing response to chemotherapy the sunflower genome provides insights into oil metabolism flowering and asterid evolution sunflower genome sequence to provide roadmap for more resilient crops hiv among people who inject drugs in the middle east and north africa systematic review and data synthesis emerging hiv epidemics among people who inject drugs in the middle east and north africa electrocatalytic hydroxymethyl furfural oxidation using high surface area nickel boride hydrogen and plastic production new catalyst with a dual function near continuous tremor and low frequency earthquake activities in the alaska aleutian subduction zone revealed by a mini seismic array slow earthquakes occur continuously in the alaska aleutian subduction zone chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis dangerous blood pressure caused by specific signalling in the brain effect of plasmodium inactivation in whole blood on the incidence of blood transfusion transmitted malaria in endemic regions the african investigation of the mirasol system aims randomised controlled trial blood transfusions in high risk malaria zones could be made safer with new blood treatment technology infrared characterization of jupiter s equatorial disturbance cycle planetary astronomers identify cycle of spectacular disturbances at jupiter s equator natural genetic variation of the cardiac transcriptome in non diseased donors and patients with dilated cardiomyopathy study of transplanted hearts reveals risk gene for cardiovascular disease alexander technique lessons or acupuncture sessions for persons with chronic neck pain trial reveals evidence of long term benefits for people with chronic neck pain does effectiveness of adolescent smoking cessation intervention endure into young adulthood ? year follow up results from a group randomized trial phone counseling found insufficient to help teen smokers stay quit into young adulthood distinct fibroblast lineages determine dermal architecture in skin development and repair skin s own cells offer hope for new ways to repair wounds reduce impact of aging pioglitazone and bladder cancer risk a multipopulation pooled cumulative exposure analysis no link found between bladder cancer use of pioglitazone or rosiglitazone avandia differentiation of swine ipsc into rod photoreceptors and their integration into the retina pig stem cell transplants the key to future research into retina treatment intrathecal substance p saporin in the dog efficacy in bone cancer pain chronic pain in dogs with bone cancer relieved with new treatment mapping of microscopic strain distributions in an alloy c ring after application of hoop stresses and stress corrosion cracking x ray diffraction technique maps strain crack propagation in metallic tubing towards elucidating the connection between epithelial mesenchymal transitions and stemness decoding the emergence of metastatic cancer stem cells human ipsc derived endothelial cells and microengineered organ chip enhance neuronal development brain s tiniest blood vessels trigger spinal motor neurons to develop intravitreous injection of aav sflt in patients with advanced neovascular age related macular degeneration a phase open label trial new gene therapy for vision loss is safe in humans study suggests dietary phosphate modulates atherogenesis and insulin resistance in apolipoprotein e knockout mice link between phosphate intake and heart disease demonstrated in new study dogs are sensitive to small variations of the earth s magnetic field dogs sense small variations in earth s magnetic field new research suggests cryptococcal meningitis screening and community based early adherence support in people with advanced hiv infection starting antiretroviral therapy in tanzania and zambia an open label randomised controlled trial new approach to hiv management in tanzania and zambia reduces deaths by almost one third treatment induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through wnt b new mechanism behind resistance to cancer treatment that could lead to better therapies physician response to patient request for unnecessary care half of primary care doctors provide unnecessary specialty referrals upon patient request colonizing islands of water on dry land on the passive dispersal of fish eggs by birds dispersal of fish eggs by water birds just a myth ? does the sex difference in competitiveness decrease in selective sub populations ? a test with intercollegiate distance runners sex difference in competitiveness even among the fastest runners cardiovascular safety of methylphenidate among children and young people with attention deficit hyperactivity disorder adhd nationwide self controlled case series study adhd medication linked to slightly increased risk of heart rhythm problems cardiovascular and neuropsychiatric events following varenicline use for smoking cessation smoking cessation drug may increase risk of adverse cardiovascular event preventive oral health intervention among old home care clients tailored preventive oral health intervention improves dental health among elderly viral outbreak in corals associated with an in situ bleaching event atypical herpes like viruses and a new megavirus infecting symbiodinium herpes outbreak other marine viruses linked to coral bleaching event climate risk assessment under uncertainty an application to main european coastal cities risky business calculating climate change losses in major european coastal cities naked mole rat transcriptome signatures of socially suppressed sexual maturation and links of reproduction to aging naked mole rats defy conventions of aging and reproduction notch and egfr pathway interaction regulates neural stem cell number and self renewal discovery of key pathway interaction may lead to therapies that aid brain growth and repair construction and characterization of a second generation pseudoinfectious west nile virus vaccine propagated using a new cultivation system new west nile and japanese encephalitis pseudoinfectious vaccines produced acute perturbation of pet neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery sids serotonin neurons contribute to fail safe mechanism that ensures recovery from interrupted breathing sugar industry sponsorship of germ free rodent studies linking sucrose to hyperlipidemia and cancer an historical analysis of internal documents sugar industry withheld evidence of sucrose s health effects nearly years ago study suggests a d human triculture system modeling neurodegeneration and neuroinflammation in alzheimer s disease microfluidic system incorporates neuroinflammation into alzheimer s in a dish model randomized crossover clinical trial of real and sham peripheral prism glasses for hemianopia peripheral prism glasses are cheap effective vision rehab tool mechanisms of tbi and visual consequences in military and veteran populations in combat vets and others high rate of vision problems after traumatic brain injury the challenge of being a young manager the effects of contingent reward and participative leadership on team level turnover depend on leader age overcoming the challenge of being a young manager venous thromboembolism in patients having knee replacement and receiving thromboprophylaxis a danish population based follow up study joint replacement surgery increases risk of blood clot formation in certain patients study finds one law to rule them all the radial acceleration relation of galaxies radial acceleration relation found in all common types of galaxies geographic variation of overweight and obesity among women in nigeria a case for nutritional transition in sub saharan africa influence of westernization spells danger for public health in nigeria raltegravir is a potent inhibitor of xmrv a virus implicated in prostate cancer and chronic fatigue syndrome anti hiv drugs inhibit emerging virus linked to prostate cancer and chronic fatigue syndrome dog allergen levels in homes with hypoallergenic compared with nonhypoallergenic dogs hypoallergenic dogs don t have lower household allergen levels than other dogs study finds international myeloma working group updated criteria for the diagnosis of multiple myeloma updated criteria for diagnosing multiple myeloma published by international research group shrubland resilience varies across soil types implications for operationalizing resilience in ecological restoration soil mapping may indicate success of brush control method unforeseen effects of supplementary feeding ungulate baiting sites as hotspots for ground nest predation deer feeding puts birds at risk research shows prenatal selective serotonin reuptake inhibitor ssri exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice possible link between autism and antidepressants use during pregnancy taf variants are associated with dysmorphic features intellectual disability and neurological manifestations discovery of x linked intellectual disability syndrome is aided by web tools intestinal failure associated liver disease. a position paper by the espghan working group of intestinal failure and intestinal transplantation intestinal failure associated liver disease new position paper a single injection of anti hiv antibodies protects against repeated shiv challenges single antibody infusions provide durable protection against hiv like virus in monkeys fungal infections associated with contaminated methylprednisolone in tennessee flesh eating fungus responsible for five deaths in wake of massive tornado exceptional power density and stability at intermediate temperatures in protonic ceramic fuel cells new fuel cell demonstrates exceptional power density and stability serum free light chain assay in monoclonal gammopathic manifestations specific criteria needed for different types of myeloma the association between prenatal stress and externalizing symptoms in childhood evidence from the avon longitudinal study of parents and children now and zen lower prenatal stress reduces risk of behavioral issues in kids randomized multicenter trial on the effect of radiation therapy on plantar fasciitis painful heel spur comparing a standard dose with a very low dose mature results after months follow up standard radiation therapy dose provides pain relief for painful heel spurs plantar fasciitis pre vaccination inflammation and b cell signalling predict age related hyporesponse to hepatitis b vaccination age related response to the hepatitis b vaccine linked to inflammation bioinformatic profiling identifies an immune related risk signature for glioblastoma researchers identify immune genes tied to common deadly brain cancer dysregulation of the als associated gene tdp leads to neuronal death and degeneration in mice malfunctioning gene associated with lou gehrig s disease leads to nerve cell death in mice maternal psychological stress after prenatal diagnosis of congenital heart disease prenatal diagnosis of congenital heart disease increases maternal stress depression and anxiety mhf mhf a histone fold containing protein complex participates in the fanconi anemia pathway via fancm newly identified proteins critical to fanconi anemia pathway dna repair function moderators of the link between marital hostility and change in spouses u depressive symptoms husbands hostile anti social behaviors increase wives symptoms of depression study shows a randomized waitlist controlled trial of cognitive behavior therapy to improve emotion regulation in children with autism cognitive behavioral therapy can improve emotion regulation in children with autism changes associated with ebola virus adaptation to novel species ebolaviruses need very few mutations to cause disease in new host species development and internal validation of a clinical rule to improve antibiotic use in children presenting to primary care with acute respiratory tract infection and cough the target prognostic cohort study decision making tool may help doctors cut unnecessary antibiotic prescribing chemodiversity of dissolved organic matter in lakes driven by climate and hydrology nature s chemical diversity reflected in swedish lakes maternal obesity alters immune cell frequencies and responses in umbilical cord blood samples maternal obesity compromises babies immune system at time of birth does family history of obesity cardiovascular and metabolic diseases influence onset and severity of childhood obesity ? risk factors involved in the early onset and severity of childhood obesity high dimensional mass cytometric analysis reveals an increase in effector regulatory t cells as a distinguishing feature of colorectal tumors discovery paves way for precision medicine in future health care reform and women s insurance coverage for breast and cervical cancer screening health reform could provide more than a million women in the u.s. with access to potentially life saving tests for breast and cervical cancer mass cytometry analysis reveals that specific intratumoral cd t cell subsets correlate with patient survival in follicular lymphoma t cell receptor diversity may be key to treatment of follicular lymphoma study finds decoding action intentions from preparatory brain activity in human parieto frontal networks researchers can predict future actions from human brain activity estimating the lost benefits of antiretroviral drug use in south africa estimate of lives lost due to delay in antiretroviral drug use for hiv aids in south africa beyond the molecular movie dynamics of bands and bonds during a photoinduced phase transition researchers monitor electron behavior during chemical reactions for the first time legal barriers to adolescent participation in research about hiv and other sexually transmitted infections legal barriers to adolescent participation in hiv sti research need to be removed activated platelets in the tumor microenvironment for targeting of antibody drug conjugates to tumors and metastases new drug brings unexpected hope in targeting cancer cells response of understory vegetation to salvage logging following a high severity wildfire vegetation resilient to salvage logging after severe wildfire calcium vitamin d supplementation serum hydroxyvitamin d concentrations and cholesterol profiles in the women s health initiative calcium vitamin d randomized trial calcium vitamin d improve cholesterol in postmenopausal women acute systemic accumulation of acrolein in mice by inhalation at a concentration similar to that in cigarette smoke toxin from tobacco smoke could increase pain in spinal cord injury high density rna microarrays synthesized in situ by photolithography rna microchips a new chapter in ribonucleic acid synthesis low hesperian p co constrained from in situ mineralogical analysis at gale crater mars curiosity exposes low co level in mars primitive atmosphere pregnancy related immune adaptation promotes the emergence of highly virulent h n influenza virus strains in allogenically pregnant mice dampened immunity during pregnancy promotes evolution of more virulent flu the painful legacy of childhood violence migraine headaches among adult survivors of adverse childhood experiences childhood adversities including witnessing parental domestic violence linked to later migraines self powered paper based electrochemical devices for sensitive point of care testing self powered paper based speds may lead to new medical diagnostic tools foley catheterisation versus oral misoprostol for induction of labour in hypertensive women in india inform a multicentre open label randomised controlled trial new study examines effectiveness of labor induction in india manufacturing gender inequality in the new economy high school training for work in blue collar communities blue collar training in high school leaves women behind divergent responses of sympatric species to livestock encroachment at fine spatiotemporal scales livestock can uproot protected wildlife from prime real estate the role of counselling in the management of patients with infertility importance of counselling in those affected by infertility rna sequencing of intestinal mucosa reveals novel pathways functionally linked to celiac disease pathogenesis rna sequencing used to discover novel genes and pathways in celiac disease us renal data system annual data report epidemiology of kidney disease in the united states kidney disease report assesses mammoth problem for the united states hyperlipidemia in early adulthood increases long term risk of coronary heart disease high cholesterol in s s increases later risk of heart disease projected scenarios for coastal first nations fisheries catch potential under climate change management challenges and opportunities climate change could cut first nations fisheries catch in half improving environmental practices in agricultural supply chains the role of company led standards grocery store program improves farmers adoption of environmental practices identification of zika virus epitopes reveals immunodominant and protective roles for dengue virus cross reactive cd t cells pre existing immunity to dengue virus shapes zika specific t cell response a surgical team with focus on staff education in a community hospital improves outcomes costs and patient satisfaction program results in happier patients lower costs in esophageal surgery pediatric mobility aid related injuries treated in us emergency departments from to more than pediatric injuries related to crutches walkers and wheelchairs each year in the us study finds multiple sclerosis effect of beta interferon treatment on survival common treatment for multiple sclerosis may prolong life mediators and moderators of long term effects of violent video games on aggressive behaviorpractice thinking and action life lessons children learn aggressive ways of thinking and behaving from violent video games study finds odor identification screening improves diagnostic classification in incipient alzheimer s disease sniff test may be useful in diagnosing early alzheimer s disease e health a position statement of the european society of cardiology esc on ehealth revolution a new vision for cardiovascular medicine bdnf val met predicts cognitive decline in the wisconsin registry for alzheimer s prevention gene mutation may speed up memory loss in alzheimer s disease incidence of antipsychotic use in relation to diagnosis of alzheimer s disease among community dwelling persons antipsychotics initiated frequently and used for long term in alzheimer s patients effect of no till and extended rotation on nutrient losses in surface runoff tillage and reduced input rotations affect runoff from agricultural fields sexual violence in the context of drug use among young adult opioid users in new york city opioid use and sexual violence among drug using young adults in nyc elective cryopreservation of all embryos with subsequent cryothaw embryo transfer in patients at risk for ovarian hyperstimulation syndrome reduces the risk of adverse obstetric outcomes a preliminary study extremely high estrogen levels may underlie complications of single birth ivf pregnancies understanding the life cycle surface land requirements of natural gas fired electricity new method to quantify life cycle land use of natural gas physical health and drinking among medical inpatients with unhealthy alcohol use a prospective study hospital interventions for medical inpatients with unhealthy drinking behaviors low load for disruptive mutations in autism genes and their biased transmission genetic analysis supports prediction that spontaneous rare mutations cause half of autism predicting long term growth in students mathematics achievement the unique contributions of motivation and cognitive strategies motivation study habits not iq determine growth in math achievement oral capsulized frozen fecal microbiota transplantation for relapsing clostridium difficile infection oral capsule as effective as invasive procedures for delivery of fecal transplant evidence based guideline summary diagnosis and treatment of limb girdle and distal dystrophies report of the guideline development subcommittee of the american academy of neurology and the practice issues review panel of the american association of neur guideline offers direction in genetic testing for certain types of muscular dystrophy resource conflict and cooperation between human host and gut microbiota implications for nutrition and health war and peace in the human gut probing the microbiome kinematics of ultra high velocity gas in the expanding molecular shell adjacent to the w supernova remnant tail of stray black hole hiding in the milky way on early starters and late bloomers the development of sexual behavior in adolescence across personality types examining the understudied pull of personality on adolescent sexual development and experience the mll branch of the compass family regulates bivalent promoters in mouse embryonic stem cells a more nuanced genetic code rules governing expression of developmental genes in embryonic stem cells linking microbial community structure to function in representative simulated systems researcher builds replica human colon to improve water quality statins reduce spirochetal burden and modulate immune responses in the c h hen mouse model of lyme disease new method to stop the spread of lyme disease a safe and potent anti cd car t cell therapy advance in car t cell therapy eliminates severe side effects presence of porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer researchers find association between oral bacteria and esophageal cancer trifluoroacetate induced small grained cspbbr perovskite films result in efficient and stable light emitting devices new approach improving stability and optical properties of perovskite films endothelial tlr and the microbiome drive cerebral cavernous malformations link between common brain disease and gut microbiome the relationship of maternal prepregnancy body mass index and pregnancy weight gain to neurocognitive function at age years among children born extremely preterm pre pregnancy obesity increases risk for neurocognitive problems in premature babies feasibility of new breeding techniques for organic farming scientists see a natural place for rewilded plants in organic farming recreational activity and facial trauma among older adults study examines facial fractures from recreational activity in adults and older carp edema virus koi sleepy disease an emerging disease in central east europe first incidence of koi sleepy disease in austria controlled release of c type natriuretic peptide by microencapsulation dampens pro inflammatory effects induced by il in cartilage explants new microcapsules have potential to repair damage caused by osteoarthritis homeostasis model assessment to detect insulin resistance and identify patients at high risk of breast cancer development national cancer institute of naples experience assessing insulin resistance can inform about breast cancer risk comparative genomic analysis of lactobacillus rhamnosus gg reveals pili containing a human mucus binding protein light shed on the secret behind probiotic bacteria promoting health home sweet home does where you live matter to working memory and other cognitive skills ? home sweet home does where you live impact student success ? climate of migration ? how climate triggered migration from southwest germany to north america during the th century climate changes triggered immigration to america in the th century study finds an in vitro evidence for caffeic acid rosmarinic acid and trans cinnamic acid as a skin protectant against radiation natural products from plants protect skin during cancer radiotherapy developing a social practice based typology of british drinking culture in implications for alcohol policy analysis. new research reveals surprising insight into british drinking culture gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood age gut bacteria contribute to ms disease progression according to study assessing real time zika risk in the united states computer model developed to assess risk of a zika epidemic in real time reproducibility of pulse wave velocity and augmentation index derived from non invasive occlusive oscillometric tonometry analysis in adolescents pulse wave analysis provides reliable information on heart health in young people decreased sgk expression and function contributes to behavioral deficits induced by traumatic stress reduced activity of a brain protein linked to post traumatic stress disorder arboreal crops on the medieval silk road archaeobotanical studies at tashbulak origins and spread of eurasian fruits traced to the ancient silk road enhanced striatal dopamine release during food stimulation in binge eating disorder binge eaters dopamine levels spike at sight smell of food concomitant thc and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood exposure to cannabis and stress in adolescence can lead to anxiety disorders in adulthood association of body mass index and age with subsequent breast cancer risk in premenopausal women higher body fat linked to lower breast cancer risk in younger women sequencing at sea challenges and experiences in ion torrent pgm sequencing during the southern line islands research expedition sequencing at sea performing real time dna sequencing in the middle of pacific ocean decoding group vocalizations the acoustic energy distribution of chorus howls is useful to detemine wolf reproduction predictive model to analyse the reproductive status of wolf packs ontogenetic migration of a female scalloped hammerhead shark sphyrna lewini in the gulf of california endangered hammerhead shark found migrating into unprotected waters national prevalence and risk factors for food allergy and relationship to asthma results from the national health and nutrition examination survey children males and blacks are at increased risk for food allergies study finds the chemokine receptor ccr plays a key role in the early memory cd ? t cell response to respiratory virus infections mobilizing white blood cells to the lung new discovery could lead to an improved influenza vaccine activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions stimulating a protein in skin cells could improve psoriasis symptoms dental maturational sequence and dental tissue proportions in the early upper paleolithic child from abrigo do lagar velho portugal year old child s teeth shed new light on human evolution quantitative fetal fibronectin at weeks of gestation to predict preterm birth in asymptomatic high risk women biomarker can predict risk of preterm birth from first half of pregnancy omega fatty acids for the primary and secondary prevention of cardiovascular disease omega supplements have little or no heart or vascular health benefit patterns of bleaching and mortality following widespread warming events in and at the hanauma bay nature preserve hawai i corals in peril at a popular hawaiian tourist destination due to global climate change ferns as healing plants in medieval mallorca spain ? evidence from human dental calculus fern plant infusion keeps the doctor away in medieval europe a new metabolic cell wall labelling method reveals peptidoglycan in chlamydia trachomatis scientists resolve decades old mystery of chlamydial anomaly self propelled particles that transport cargo through flowing blood and halt hemorrhage self propelled powder designed to stop severe bleeding incidence of human papillomavirus hpv positive tonsillar carcinoma in stockholm sweden an epidemic of viral induced carcinoma ? sharp increase in hpv positive tonsil cancer found association of worksite wellness center attendance with weight loss and health care cost savings work site wellness centers equate to weight loss and health care savings expert says moral schemas in articulation and intuition how religious people evaluate human reproductive genetic technologies religious people more likely to oppose reproductive technologies mif and d dt are potential disease severity modifiers in male ms subjects new markers for severe form of multiple sclerosis uncovered the effect of assisted exercise frequency on bone strength in very low birth weight preterm infants a randomized control trial more frequent exercise therapy benefits bone strength in very low weight pre term infants san andreas fault earthquake chronology and lake cahuilla history at coachella california los angeles basin long overdue for major earthquake lake effect theory sinks but quake timing questions go on online seizure prediction using an adaptive learning approach better prediction for epileptic seizures through adaptive learning approach ccr antagonist blocks metastasis of basal breast cancer cells hiv drug may slow down metastatic breast cancer medical versus surgical management for gastro oesophageal reflux disease gord in adults severe acid reflux stomach wraps effective in short to medium term phylogenomics and antimicrobial resistance of the leprosy bacillus mycobacterium leprae leprosy s drug resistance and origin revealed by genome analysis the tomato genome sequence provides insights into fleshy fruit evolution tomato genome gets fully sequenced paves way to healthier fruits veggies toll like receptor mediated ire activation as a therapeutic target for inflammatory arthritis researchers discover specific inhibitor for rheumatoid arthritis treatment levetiracetam versus phenytoin for second line treatment of paediatric convulsive status epilepticus eclipse a multicentre open label randomised trial alternative treatment for epileptic seizures in children identified intestinal epithelial cell toll like receptor regulates the intestinal microbiota to prevent low grade inflammation and metabolic syndrome in mice healthy gut microbiota can prevent metabolic syndrome researchers say extra epitopic hepatitis c virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor b hepatitis c mutations outrun immune systems lab study shows protecting healthcare personnel in outpatient settings the influence of mandatory versus nonmandatory influenza vaccination policies on workplace absenteeism during multiple respiratory virus seasons mandatory flu vaccines for healthcare workers reduce absenteeism apolipoprotein e causes age dependent disruption of slow gamma oscillations during hippocampal sharp wave ripples gene linked to alzheimer s disease impairs memory by disrupting brain s playback system positive serum ethanol level and mortality in moderate to severe traumatic brain injury alcohol in bloodstream associated with lower risk of death from head injury impacts of st century climate change on global air pollution related premature mortality air pollution worsened by climate change set to be more potent killer in the st century candida albicans sod represents the prototype of an unprecedented class of cu only superoxide dismutases required for pathogen defense scientists unlock secrets of protein produced by disease causing fungus reconnaissance of antibiotics and associated microbial risks in seafood sold in the united states fish tale new study evaluates antibiotic content in farm raised fish major range extensions for two genera of the parasitoid subtribe facitorina with a new generic synonymy braconidae rogadinae yeliconini hollywood star brad pitt shares a name with a new wasp species from south africa the impact of acute stress on the neural processing of food cues in bulimia nervosa replication in two samples. under stress brains of bulimics respond differently to food cherry flavoured electronic cigarettes expose users to the inhalation irritant benzaldehyde users of cherry flavored e cigarettes may be exposed to higher levels of respiratory irritant gold nanorod delivery of an ssrna immune activator inhibits pandemic h n influenza viral replication to attack h n other flu viruses gold nanorods deliver potent payload gender gaps in achievement and participation in multiple introductory biology classrooms more than half of biology majors are women yet gender gaps remain in science classrooms the transcription factor gata enables self renewal of colon adenoma stem cells by repressing bmp gene expression colon has safety mechanism that restricts tumor formation plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis cell biology a molecular rivet for long range force transmission forbidden fruit human settlement and abundant fruit create an ecological trap for an apex omnivore forbidden fruit a fatal temptation for grizzly bears in southeastern british columbia farm level and community aggregate economic impacts of adopting climate smart agricultural practices in three mega environments simple steps to climate proof farms have big potential upside for tropical farmers an official critical care societies collaborative statement burnout syndrome in critical care health care professionals critical care health care professionals have high rates of burnout syndrome cumulative estimates of sea turtle bycatch and mortality in usa fisheries between and accidental sea turtle deaths drop percent in u.s. fisheries improvements in fishing equipment seem to be preventing lethal bycatch reversal of apoe induced recycling block as a novel prevention approach for alzheimer s disease path to vaccine or drug for late onset alzheimer s coronary artery plaque characteristics and treatment with biologic therapy in severe psoriasis results from a prospective observational study study links psoriasis treatment and improvement in heart artery disease folic acid pyridoxine and cyanocobalamin combination treatment and age related macular degeneration in women the women s antioxidant and folic acid cardiovascular study vitamin b and folic acid may reduce risk of age related vision loss estimating methane emissions from underground coal and natural gas production in southwestern pennsylvania measuring methane from coal and gas in pennsylvania informative mitochondrial genome of a year old giant panda from southern china reveals a new panda lineage year old panda from cave in southern china belongs to distinct long lost lineage maternal dietary patterns and preterm delivery results from large prospective cohort study mother s diet linked to premature birth fruits vegetables linked to reduced risk of preterm delivery the effect of a plant based low carbohydrate eco atkins diet on body weight and blood lipid concentrations in hyperlipidemic subjects eco atkins plant based low carb diet may promote weight loss and improve cholesterol levels trends in hospitalization for community associated methicillin resistant staphylococcus aureus in new york city data from new york state s statewide planning and research cooperative system community acquired mrsa cases on the rise in new york city study suggests gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal enterococcus common acid reflux medications promote chronic liver disease small molecules enable highly efficient neuronal conversion of human fibroblasts skin and umbilical cord cells turned directly into nerve cells three dimensional atomic scale electron density reconstruction of octahedral tilt epitaxy in functional perovskites a d imaging technique unlocks properties of perovskite crystals nanog metabolically reprograms tumor initiating stem like cells through tumorigenic changes in oxidative phosphorylation and fatty acid metabolism scientists root out the bad seeds of liver cancer contribution of opioid involved poisoning to the change in life expectancy in the united states contribution of opioid related deaths to the change in life expectancy in the us phytoplankton bacterial interactions mediate micronutrient colimitation at the coastal antarctic sea ice edge research spotlights a previously unknown microbial drama playing in the southern ocean the scaffold proteins of lignin biosynthetic cytochrome p enzymes new details of molecular machinery that builds plant cell wall components palliative care teams cost saving effect is larger for cancer patients with higher numbers of comorbidities palliative care offers greater cost savings for cancer patients with multiple chronic conditions management implications of highly resolved hierarchical population genetic structure in thinhorn sheep population of rare stone s sheep smaller than previously thought increasing jellyfish populations trends in large marine ecosystems jellyfish on the rise in world s coastal ecosytems high serum immunoglobulin g and m levels predict freedom from adverse cardiovascular events in hypertension a nested case control substudy of the anglo scandinavian cardiac outcomes trial immune system linked to lower heart attack risk suggests study second impact syndrome in football new imaging and insights into a rare and devastating condition second impact syndrome in a high school football player researchers use imaging findings to chronicle new details towards nonspecific detection of malignant cervical cells with fluorescent silica beads novel cancer detection method uses tiny silica beads to adhere to cells tooth development histology and enamel microstructure in changchunsaurus parvus implications for dental evolution in ornithopod dinosaurs the teeth of changchunsaurus rare insight into ornithopod dinosaur tooth evolution differentiation of human protein induced pluripotent stem cells toward a retinal pigment epithelial cell fate research offers hope for better treatments for retinal degenerative diseases n myc downstream regulated gene ndrg a candidate tumor suppressor gene and potential biomarker for colorectal cancer promising biomarker and candidate tumor suppressor gene identified for colorectal cancer the increased risk for autoimmune diseases in patients with eating disorders patients with eating disorders have increased risk of autoimmune diseases testosterone replacement therapy and hospitalization rates in men with copd testosterone replacement therapy may slow the progression of copd dengue virus ns cytokine independent vascular leak is dependent on endothelial glycocalyx components scientists unravel likely causes of blood vessel leakage in severe dengue expandable arterial endothelial precursors from human cd cells differ in their proclivity to undergo an endothelial to mesenchymal transition new stem cell method sheds light on a tell tale sign of heart disease full content is available to subscribers subscribe learn more original investigation january accuracy of reports of lifetime mental and physical disorders mental disorders in mid life older adulthood more prevalent than previously reported spinocerebellar ataxia type protein aggregates cause deficits in motor learning and cerebellar plasticity ataxia mouse model eye blink conditioning for early diagnosis of human disease sca dixdc contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via gsk and wnt catenin signaling gene links risk of psychiatric disease to reduced synapse numbers a universal influenza vaccine the strategic plan for the national institute of allergy and infectious diseases strategic plan for developing a universal influenza vaccine burns from e cigarettes and other electronic nicotine delivery systems severe burns injuries from e cigarette explosions go under reported across the country adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke a new treatment for stroke in mice reduces brain damage and promotes motor recovery does the raising iq raising g distinction explain the fadeout effect ? iq and fade out effect environmental intervention can raise general intelligence but the effects aren t permanent influence of demographic variables on uptake of domestic solar photovoltaic technology powerful change a profile of today s solar consumer evaluation of postural control in patients with glaucoma using a virtual reality environment virtual reality may be effective tool for evaluating balance control in glaucoma patients risks of biological invasion on the belt and road biosecurity strategy needed for china s belt and road initiative effect of vortex inlet mode on low power cylindrical hall thruster new thruster design increases efficiency for future spaceflight a longitudinal analysis of drinking and victimization in college women is there a reciprocal relationship ? past sexual assault triples risk of future assault for college women cdk inhibitor palbociclib pd in rb advanced breast cancer phase ii activity safety and predictive biomarker assessment palbociclib shows promise in patients with hormone resistant breast cancer nanotube structured na v o as a cathode material for sodium ion batteries with high rate and stable cycle performances sodium is the new lithium researchers find a way to boost sodium ion battery performance a research strategy to discover the environmental causes of autism and neurodevelopmental disabilities top ten toxic chemicals suspected to cause autism and learning disabilities invasive coqui frogs are associated with greater abundances of nonnative birds in hawaii usa invasive frogs give invasive birds a boost in hawaii reactivation of pten tumor suppressor for cancer treatment through inhibition of a myc wwp inhibitory pathway natural compound found in broccoli reawakens the function of potent tumor suppressor compact polyvalent mannose quantum dots as sensitive ratiometric fret probes for multivalent protein ligand interactions sweet quantum dots light the way for new hiv and ebola treatment slowdown of the walker circulation driven by tropical indo pacific warming tropical indo pacific climate shifts to a more el ni o like state proximity induced high temperature superconductivity in the topological insulators bi se and bi te high temperature superconductivity induced in a semiconductor with scotch tape genetic evidence that captured retroviral envelope syncytins contribute to myoblast fusion and muscle sexual dimorphism in mice placenta in females muscle mass in males dual heritage of a virus an evidence based program model for facilitating therapeutic responses to pain based behavior in residential care residential child care project addresses emotional pain without causing it preliminary evaluation of a school based resilience promoting intervention in a high risk population application of an exploratory two cohort treatment control design pupils mental health improved through school based program climate related sea level variations over the past two millennia researchers link fastest sea level rise in two millennia to increasing temperatures memo efficacy durability and effect of cognitive training and psychosocial intervention in individuals with mild cognitive impairment can training improve memory thinking abilities in older adults with cognitive impairment ? experimental evidence of genome wide impact of ecological selection during early stages of speciation with gene flow recent agricultural pest stems from one fly generation s big genetic shift evolution study finds gene therapy induced antigen specific tregs inhibit neuro inflammation and reverse disease in a mouse model of multiple sclerosis unique gene therapy prevents reverses multiple sclerosis in animal model lofar discovery of the fastest spinning millisecond pulsar in the galactic field extreme telescopes find the second fastest spinning pulsar featured article transplantation of mesenchymal stem cells carrying the human receptor activity modifying protein gene improves cardiac function and inhibits neointimal proliferation in the carotid angioplasty and myocardial infarction rabbit model effect of receptor activity modifying protein on vascular smooth muscle cells synthetic spider silk production on a laboratory scale the future of biomaterial manufacturing spider silk production from bacteria dolphins can maintain vigilant behavior through echolocation for days without interruption or cognitive impairment dolphins can remain alert for up to days at a time with no sign of fatigue a synthetic m protein peptide synergizes with a cxc chemokine protease to induce vaccine mediated protection against virulent streptococcal pyoderma and bacteremia researchers create new combination vaccine to fight streptococcus a effects of iron supplementation of low birth weight infants on cognition and behavior at years a randomized controlled trial iron supplements have long term benefits for low birth weight babies peer victimization and social dominance as intervening variables of the link between peer liking and relational aggression rebels without applause new study on peer victimization effect of interleukin inhibition with canakinumab on incident lung cancer in patients with atherosclerosis exploratory results from a randomised double blind placebo controlled trial anti inflammatory therapy cuts risk of lung cancer generalized sturmians in the time dependent frame effect of a fullerene confining potential ionization mechanisms of captive atoms struck by light matter single cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species single cell sequencing reveals landscape of immune cell subtypes in lung cancer tumors middle eastern plant communities tolerate years of drought in a multi site climate manipulation experiment mediterranean semi arid ecosystems prove resistant to climate change spatiotemporal drought variability in northwestern africa over the last nine centuries th century one of driest in nine centuries for northwest africa characteristics of hospitalizations for heart failure with preserved ejection fraction major new study provides important insights for effective treatment of heart failure with pef individual patterns of complexity in cystic fibrosis lung microbiota including predator bacteria over a year period predatory bacteria found in study of cystic fibrosis patients lung microbiome a city scale assessment reveals that native forest types and overstory species dominate new york city forests missing the forest for the trees an unexpected picture of new york city forests early persistent blood eosinophilia in necrotizing enterocolitis is a predictor of late complications new predictor of health complications can identify high risk preemies necroptosis drives motor neuron death in models of both sporadic and familial als toxin from brain cells triggers neuron loss in human als model gas vs electric heating system fuel source implications on low energy single family dwelling sustainability performance gas vs. electric ? fuel choice affects efforts to achieve low energy and low impact homes fast response stiffness tunable soft actuator by hybrid multimaterial d printing multimaterial d printing used to develop fast response stiffness tunable soft actuator a neutralizing human monoclonal antibody protects african green monkeys from hendra virus challenge antibody treatment protects monkeys from hendra virus disease changes in bee community structure hymenoptera apoidea under three different land use conditions bee diversity and richness decline as anthropogenic activity increases scientists confirm insurance coverage is associated with mortality after gunshot trauma insurance status of gunshot trauma patients affects mortality outcomes suicide and suicide attempts in children and adolescents in the child welfare system rates of suicide attempts and hospitalizations in children and adolescents in canada s child welfare system conservation biogeography of the us mexico border a transcontinental risk assessment of barriers to animal dispersal border fences pose threats to wildlife on us mexico border study shows the clinical utility of dna based screening for fetal aneuploidy by primary obstetrical care providers in the general pregnancy population research supports expanded use of cell free dna prenatal testing functional diversity and community assembly of river invertebrates show globally consistent responses to decreasing glacier cover mapping the global impact of shrinking glaciers on river invertebrates maslinic acid a natural triterpene from olea europaea l. induces apoptosis in ht human colon cancer cells via the mitochondrial apoptotic pathway olive skins provide natural defense against colon cancer study suggests in vivo delivery of synthetic human dna encoded monoclonal antibodies protect against ebolavirus infection in a mouse model synthetic dna delivered antibodies protect against ebola in preclinical studies impact of obesity and knee osteoarthritis on morbidity and mortality in older americans obesity and knee osteoarthritis shorten healthy years of life medicaid enrollment policy increased smoking cessation among pregnant women but had no impact on birth outcomes medicaid enrollment policies help pregnant women quit smoking but have little impact on adverse birth outcomes alcohol consumption is inversely associated with risk and severity of rheumatoid arthritis alcohol reduces the severity of rheumatoid arthritis study finds mitochondrial genomes from new zealand s extinct adzebills aves aptornithidae aptornis support a sister taxon relationship with the afro madagascan sarothruridae origins of giant extinct new zealand bird traced to africa maternal prepregnancy obesity is an independent risk factor for frequent wheezing in infants by age months maternal obesity increases the risk of frequent wheezing in offspring vegetarian dietary patterns and mortality in adventist health study vegetarian diets associated with lower risk of death hardware intrinsic security primitives enabled by analogue state and nonlinear conductance variations in integrated memristors emerging memory devices used to develop electronic circuits for cybersecurity applications endogenous reprogramming of alpha cells into beta cells induced by viral gene therapy reverses autoimmune diabetes gene therapy restores normal blood glucose levels in mice with type diabetes antiproliferation activity of a small molecule repressor of liver receptor homolog novel platform developed for treatment of breast pancreatic cancer polyglutamation of methotrexate with common polymorphisms in reduced folate carrier aminoimidazole carboxamide ribonucleotide transformylase and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis new clinical practice guidelines developed for juvenile idiopathic arthritis security and privacy analysis of mobile health applications the alarming state of practice mobile health applications put the personal data of millions of users at risk colossal injection of catalyst atoms into silicon nanowires a giant step toward miniaturization nanotechnology transforms molecular beams into functional nano devices characterization of macaque pulmonary fluid proteome during monkeypox infection dynamics of host response deadly monkeypox virus might cause disease by breaking down lung tissue antigen specific immunotherapeutic vaccine for experimental autoimmune myasthenia gravis myasthenia gravis efficacy of potential therapy for autoimmune disorder of muscle weakness the merger that led to the formation of the milky way s inner stellar halo and thick disk astronomers discover the giant that shaped the early days of our milky way fluctuations in anthropogenic nighttime lights from satellite imagery for five cities in niger and nigeria open access satellite data allows tracking of seasonal population movements colitogenic bacteroides thetaiotaomicron antigens access host immune cells in a sulfatase dependent manner via outer membrane vesicles new insight into inflammatory bowel disease may lead to better treatments acute respiratory infection and use of nonsteroidal anti inflammatory drugs on risk of acute myocardial infarction a nationwide case crossover study common pain relievers may increase heart attack risk during respiratory infections risk perceptions and subsequent sexual behaviors after hpv vaccination in adolescents beliefs about hpv vaccine do not lead to initiation of sex or risky sexual behavior among teen girls young women study shows annual report on health care for children and youth in the united states focus on trends in hospital use and quality hospitalizations due to skin and soft tissue infections among children have doubled low cost high volume health services contribute the most to unnecessary health spending low cost high volume services make up big portion of spending on unneeded health care metastatic cancers promote cachexia through zip upregulation in skeletal muscle excess zinc in muscles contributes to wasting syndrome in cancer an egg adult association gender and reproduction in pterosaurs how to tell a pterodactyl s sex dino era riddle solved by new fossil find the mark of vegetation change on earth s surface energy balance land use change has warmed earth s surface protein barcodes enable high dimensional single cell crispr screens critical cancer immunity genes identified using new genetic barcoding technology co induced ocean acidification increases anxiety in rockfish via alteration of gabaa receptor functioning rising ocean acidification leads to anxiety in fish tooth loss increases the risk of diminished cognitive function a systematic review and meta analysis tooth loss increases the risk of diminished cognitive function redesign of a cross reactive antibody to dengue virus with broad spectrum activity and increased in vivo potency research advances therapy to protect against dengue virus escue of learning and memory deficits in the human non syndromic intellectual disability cereblon knockout mouse model by targeting the ampk mtorc translational pathway mouse model of intellectual disability isolates learning gene chronic nutrient enrichment increases prevalence and severity of coral disease and bleaching large study shows pollution impact on coral reefs and offers solution trends in hospitalizations of children with inflammatory bowel disease within the united states from to dramatic increase in hospitalization of us children with inflammatory bowel disease adverse analytical findings with clenbuterol among u soccer players attributed to food contamination issues clenbuterol in livestock farming may affect results of doping controls in sport influence of race and ethnicity on access to care among children with frequent ear infections race and ethnicity impact access to care for children with frequent ear infections injurious falls and syncope in older community dwelling adults meeting inclusion criteria for sprint researchers advise caution about recent us advice on aggressively lowering blood pressure symptomatic effect of chondroitin sulfate in hand osteoarthritis the finger osteoarthritis chondroitin treatment study facts chondroitin sulfate improves hand function relieves morning stiffness caused by osteoarthritis study finds girls early sweetened carbonated beverage intake predicts different patterns of beverage and nutrient intake across childhood and adolescence early consumption of soda indicator of unhealthy diet study finds a reservoir species for the emerging amphibian pathogen batrachochytrium dendrobatidis thrives in a landscape decimated by disease common north american frog identified as carrier of deadly amphibian disease investigating the role of state permitting and agriculture agencies in addressing public health concerns related to industrial food animal production agencies often hindered in addressing health concerns from industrial animal production effectiveness of job search interventions a meta analytic review. motivation enhancement key for success in job training programs diagnostically relevant facial gestalt information from ordinary photos computer aided diagnosis of rare genetic disorders from family snaps differences in alcohol brand consumption among underage youth by age gender and race ethnicity united states underage drinkers brand preferences vary by race age study finds high long term cortisol levels measured in scalp hair are associated with a history of cardiovascular disease hair analysis reveals elevated stress hormone levels raise cardiovascular risk impact of statin discontinuation on mortality in patients with rheumatoid arthritis a population based study stopping statin therapy increases risk of death for rheumatoid arthritis patients marine mammals and sea turtles listed under the u.s. endangered species act are recovering marine mammals and sea turtles recovering after endangered species act protection guidelines for the diagnosis and management of food allergy in the united states report of the niaid sponsored expert panel clinical guidelines to reduce risk of peanut allergy temperature mediated biotic interactions influence enemy release of nonnative species in warming environments climate warming may have unexpected impact on invasive species study finds assessment of hydrological alterations on wandering beetle assemblages coleoptera carabidae and tenebrionidae in coastal wetlands of arid mediterranean systems increased irrigation in wetland linked to reduction of tenebrionid beetles gray matter changes following cognitive behavioral therapy for patients with comorbid fibromyalgia and insomnia a pilot study insomnia therapy may slow or reverse cortical gray matter atrophy in fibromyalgia association of circulating cholesteryl ester transfer protein activity with incidence of cardiovascular disease in the community low cholesterol transfer protein activity associated with heart disease risk a liquid metal reaction environment for the room temperature synthesis of atomically thin metal oxides liquid metal discovery ushers in new wave of chemistry and electronics racial disparities in adoption of axillary sentinel lymph node biopsy and lymphedema risk in women with breast cancer racial disparities in sentinel lymph node biopsy in women with breast cancer gestational stress induces the unfolded protein response resulting in heart defects world first discovery gets to the heart of birth defects very low mammographic breast density predicts poorer outcome in patients with invasive breast cancer low breast density in mammography worsens breast cancer prognosis position of the american dietetic association vegetarian diets vegetarian diets can help prevent chronic diseases american dietetic association says blue light exposure decreases systolic blood pressure arterial stiffness and improves endothelial function in humans blue light can reduce blood pressure study suggests reconstructing the molecular phylogeny of giant sengis macroscelidea macroscelididae rhynchocyon revising a mammal branch on tree of life food and beverage cues in uk and irish children television programming unhealthy food and drinks have starring role in kids tv programs uk study finds human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape replacing insulin through stem cell derived pancreatic cells under the skin restoring the on switch in blind retinas opto mglur a next generation cell tailored optogenetic tool light in sight a step towards a potential therapy for acquired blindness personality and perpetration narcissism among college sexual assault perpetrators narcissism linked to sexual assault perpetration in college study finds association of viral suppression with lower aids defining and non aids defining cancer incidence in hiv infected veterans long periods of viral suppression shown to reduce cancer risk in aging hiv population outcomes of nevirapine and efavirenz based antiretroviral therapy when coadministered with rifampicin based antitubercular therapy certain hiv treatment less effective when used with anti tb therapy nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination new compounds protect nervous system from the structural damage characteristic of multiple sclerosis mutations in hyal encoding hyaluronidase cause a syndrome of orofacial clefting and cor triatriatum sinister in humans and mice mutations responsible for cleft palate and related birth defects identified the large principle of cellular reprogramming lost acquired and retained gene expression in foreskin and amniotic fluid derived human ips cells stem cells from amniotic fluid reprogrammed amniotic fluid cells can generate all types of body cells intracellular ketoglutarate maintains the pluripotency of embryonic stem cells discovery links shift in metabolism to stem cell renewal an empirical examination of echo chambers in us climate policy networks climate change debate fueled by echo chambers new study finds a modified retrovirus vector for x linked severe combined immunodeficiency gene therapy shows promise for severe combined immunodeficiency lipoic acid and bone marrow derived cells therapy induce angiogenesis and cell proliferation after focal brain injury brain injuries in mice treated using bone marrow stem cells antioxidants spectrographic analyses reveal signals of individuality and kinship in the ultrasonic courtship vocalizations of wild house mice tiny crooners male house mice sing songs to impress the girls podoplanin expression in primary brain tumors induces platelet aggregation and increases risk of venous thromboembolism cause of thrombosis in patients with malignant brain tumors discovered phylogeography of lethal male fighting in a social spider mite why some mites are mightier than others the evolution of lethal fighting in a spider mite effects of coffee bean aroma on the rat brain stressed by sleep deprivation a selected transcript and d gel based proteome analysis coffee s aroma kick starts genes in the brain paleoceanographic insights on recent oxygen minimum zone expansion lessons for modern oceanography smothered oceans extreme oxygen loss in oceans accompanied past global climate change transferring a synthetic gene circuit from yeast to mammalian cells synthetic circuit allows dialing gene expression up or down in human cells abnormal visual gain control in a parkinson s disease model visual clue to new parkinson s disease therapies non nutritive polyol sweeteners differ in insecticidal activity when ingested by adultdrosophila melanogaster diptera drosophilidae ladykiller artificial sweetener proves deadly for female flies characterizing properties and drivers of long distance movements by elephants loxodonta africana in the gourma mali violence in mali threatening survival of endangered elephants hiv replication in the central nervous system occurs in two distinct cell types distinct aids viruses found in cerebrospinal fluid of people with hiv dementia identification of differentially expressed proteins in the cervical mucosa of hiv resistant sex workers vaginal proteins in hiv resistant prostitutes suggest new prevention measures instructor misbehaviors impede students cognitive learning testing the causal assumption hostile teachers can lose students percent on test scores a systems approach to improving tdap immunization within community based family practice settings working differently and better by transforming the structure and process of care tdap booster vaccine rates triple at family care clinics using automated reminders thrombectomy within hours after symptom onset in ischemic stroke game changer for stroke treatment better function after stroke if clots removed invader or resident ? ancient dna reveals rapid species turnover in new zealand little penguins new zealand s little penguins are recent australian invaders phosphorylation of wrinkled by kin results in its proteasomal degradation providing a link between energy homeostasis and lipid synthesis study finds link between sugar signaling regulation of oil production in plants alterations in dna methylation of fkbp as a determinant of blood brain correlation of glucocorticoid exposure dna modifications measured in blood signal related changes in the brain reaching experience increases face preference in month old infants early motor experiences give infants a social jump start mechanism for initiation of food allergy dependence on skin barrier mutations and environmental allergen costimulation food allergy linked to skin exposure and genetics study finds physical activity interventions among adults with arthritis meta analysis of outcomes incorporating education in exercise programs increases benefits for arthritis patients nature divided scientists united u.s. mexico border wall threatens biodiversity and binational conservation scientists warn that proposed us mexico border wall threatens biodiversity conservation wet wrap therapy in children with moderate to severe atopic dermatitis in a multidisciplinary treatment program wet wraps cut need for drugs in kids with eczema designer curved space geometry for relativistic fermions in weyl metamaterials new quantum materials offer novel route to d electronic devices identifying novel strategies for treating human hair loss disorders cyclosporine a suppresses the wnt inhibitor sfrp in the dermal papilla of human scalp hair follicles fringe benefits drug side effects could treat human hair loss quantitating organoleptic volatile phenols in smoke exposed vitis vinifera berries a definitive method to detect wildfire tainted wine grapes twitter k h networks in action advancing biomedical literature for drug search new role for twitter early warning system for bad drug interactions prevalence and significance of sleep disordered breathing in adolescent athletes study of young athletes suggests snoring and sleep apnea are linked to sudden cardiac death amplification of oncolytic vaccinia virus widespread tumor cell killing by sunitinib through multiple mechanisms cancer killing virus acts by alerting immune system mother s environmental tobacco smoke exposure during pregnancy and externalizing behavior problems in children second hand smoke linked to children s behavior problems use of a vaginal ring containing dapivirine for hiv prevention in women dapivirine vaginal ring helped protect women against hiv in aspire phase iii trial gender identity sexual orientation and eating related pathology in a national sample of college students sexual orientation gender identity linked to eating disorders cost energy and environmental impact of automated electric taxi fleets in manhattan fleet of automated electric taxis could deliver environmental and energy benefits the worldwide importance of honey bees as pollinators in natural habitats worldwide importance of honey bees for natural habitats captured in new report oral health in transition the hadza foragers of tanzania oral health key to understanding humanity s past study says in utero nanoparticle delivery for site specific genome editing gene editing technique cures genetic disorder in utero cellular and circuit mechanisms shaping the perceptual properties of the primate fovea a close look at sharp vision in eye structure seen only in humans and other primates running intensity fluctuations indicate temporary performance decrement in top class football more sprints in top class soccer necessitates new and individualized training routines coexpression of normally incompatible developmental pathways in retinoblastoma genesis childhood eye tumor made up of hybrid cells with jumbled development neuronal representation of numerosity zero in the primate parieto frontal number network brain processes which lead to the concept of zero on the number line suppressed phase separation of mixed halide perovskites confined in endotaxial matrices across the spectrum researchers find way to stabilize color of light in next gen material impaired endothelial function in preadolescent children with type diabetes early signs of heart disease in preadolescent children with type diabetes inducible chromatin priming is associated with the establishment of immunological memory in t cells immune system maintains a memory of past infections by priming genes for future encounters plastic and immobile unequal intergenerational mobility by genetic sensitivity score within sibling pairs sensitive genotypes yield disadvantage in poor families but advantage in wealthier ones strengthening the detection of and early response to public health emergencies lessons from the west african ebola epidemic global health experts outline lessons to be learned from ebola epidemic facing opioids in the shadow of the hiv epidemic the opioid crisis what we should learn from the aids epidemic the relationship between changes to minimum alcohol prices outlet densities and alcohol attributable deaths in british columbia in drop in alcohol related deaths by nearly a third follows minimum alcohol price increase of percent network anatomy and in vivo physiology from a group of visual cortical neurons web crawling the brain d nanoscale model of neural circuit created il signaling controls the induced regulatory t cell th cell balance via nf b activation and stat transcription factors cytokine controls immune cells that trigger inflammatory bowel disease study finds year old specialised bone technology in the aterian middle stone age of north africa bone knife from morocco is oldest specialized tool associated with aterian culture the white nose syndrome transcriptome activation of anti fungal host responses in wing tissue of hibernating little brown myotis hibernating bats mount a partial immune response against white nose fungus the glia neuron lactate shuttle and elevated ros promote lipid synthesis in neurons and lipid droplet accumulation in glia via apoe d breakdown of brain cells metabolic collaboration linked to alzheimer s disease accuracy of urinary human papillomavirus testing for presence of cervical hpv systematic review and meta analysis urine hpv test could offer non invasive alternative to conventional smear improve screening uptake gene expression plasticity as a mechanism of coral adaptation to a variable environment new coral research exposes genomic underpinnings of adaptation integrating evolutionary biology with digital arts to quantify ecological constraints on vision based behaviour animation meets biology shedding new light on animal behavior a circumbinary debris disk in a polluted white dwarf system first evidence of rocky planet formation in tatooine like system first documented predation of sika deer cervus nippon by golden eagle aquila chrysaetos in russian far east eagle vs. deer camera trap shows golden eagle capturing sika deer distribution of lipid parameters according to different socio economic indicators the epic norfolk prospective population study socioeconomic status gender are associated with differences in cholesterol levels relationship between physical activity cognition and alzheimer pathology in autosomal dominant alzheimer s disease exercise may delay cognitive decline in people with rare alzheimer s disease the impact of national level interventions to improve hygiene on the incidence of irritant contact dermatitis in healthcare workers changes in incidence from and interrupted times series analysis hand washing focus in hospitals has led to rise in worker dermatitis program director perceptions of surgical resident training and patient care under flexible duty hour requirements surgery residency program directors believe flexible duty hours improve continuity of care maternal hiv envelope specific antibody responses and reduced risk of perinatal transmission antibody response linked to lower mother to child hiv transmission origins of house mice in ecological niches created by settled hunter gatherers in the levant y ago mouse in the house tells tale of human settlement outcomes of donor oocyte cycles in assisted reproduction increase seen in donor eggs for in vitro fertilization improved outcomes prevalence of antibody to toxoplasma gondii and trichinella spp. in feral pigs sus scrofa of eastern north carolina wild hogs researchers examine impact of feral pigs in eastern north carolina changes in children s meal orders following healthy menu modifications at a regional us restaurant chain healthy children s menu items tied to healthier ordering patterns sustained restaurant revenue insights into wolf presence in human dominated landscapes the relative role of food availability humans and landscape attributes the iberian wolf lives close to humans more for refuge than for prey environmental intervention in carryout restaurants increases sales of healthy menu items in a low income urban setting offering healthier options at carryout stores improves bottom line amyloid pathology and cerebral amyloid angiopathy are frequent in iatrogenic creutzfeldt jakob disease after dural grafting alzheimer type brain pathology after transplantation of dura mater towards inferring earthquake patterns from geodetic observations of interseismic coupling aseismic slip as a barrier to earthquake propagation modulation of ad neuropathology and memory impairments by the isoprostane f is mediated by the thromboxane receptor brain receptor cell could be new target for alzheimer s frequent sexual activity predicts specific cognitive abilities in older adults frequent sexual activity can boost brain power in older adults intratympanic methylprednisolone versus gentamicin in patients with unilateral m ni re s disease a randomised double blind comparative effectiveness trial severe dizziness treated with steroid injections into the eardrum patterns of opioid use and risk of opioid overdose death among medicaid patients in medicaid patients fatal overdose risk rises with opioid dose and sedative hypnotic use parkinson s disease linked dnajc mutation aggravates alpha synuclein induced neurotoxicity through perturbation of endosomal trafficking mechanism of familial parkinson s disease clarified in fruit fly model association of cannabis use in adolescence and risk of depression anxiety and suicidality in young adulthood a systematic review and meta analysis cannabis use in teens linked to risk of depression in young adults hiit improves left ventricular exercise response in adults with type diabetes high intensity exercise may restore heart function in people with type diabetes runx regulates endochondral ossification through control of chondrocyte proliferation and differentiation role of a master gene in skeletal formation probed by researcher use of mobile devices social media and crowdsourcing as digital strategies to improve emergency cardiovascular care a scientific statement from the american heart association digital strategies show promise for emergency heart and stroke care differential growth patterns among healthy infants fed protein hydrolysate or cow milk formulas not all infant formulas are alike differential effects on weight gain echinophyllia tarae sp. n. cnidaria anthozoa scleractinia a new reef coral species from the gambier islands french polynesia a new coral reef species from the gambier islands french polynesia comparative analysis of rna sequencing methods for degraded or low input samples new biowire technology matures human heart by mimicking fetal heartrate a large genome wide association study of age related hearing impairment using electronic health records electronic records help link genes to age related hearing loss structure spatial dynamics and stability of novel seed dispersal mutualistic networks in hawai i novel hawaiian communities operate similarly to native ecosystems sociodemographic predictors of pattern and volume of alcohol consumption across hispanics blacks and whites year trend alcohol and ethnicity drinking trends increase for whites blacks and hispanics molecular transitions from papillomavirus infection to cervical precancer and cancer role of stromal estrogen receptor signaling study redefines role of estrogen in cervical cancer molecular triage of premalignant lesions in liquid based cervical cytology and circulating cell free dna from urine using a panel of methylated human papilloma virus and host genes scientists advance a novel urine test to predict high risk cervical cancer utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment novel strategy shows promise for earlier detection of alzheimer s disease the us president s malaria initiative and under child mortality in sub saharan africa a difference in differences analysis us aid to combat malaria in africa is associated with reduced risk of childhood mortality multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis gene variations linked to intestinal blockage in newborns with cystic fibrosis carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities synthetic biology research could fuel for cars or household power supplies be created from naturally occurring fatty acids ? trends and cyclical variation in the incidence of childhood type diabetes in european centres in the year period a multicentre prospective registration study year study shows that incidence of type diabetes is increasing by more than percent per year in europe seismic constraints on caldera dynamics from the axial seamount eruption underwater volcano s eruption captured in exquisite detail by seafloor observatory influenza viruses with rearranged genomes as live attenuated vaccines cleverly designed vaccine blocks h avian influenza in animal models dynamics of kuramoto oscillators with time delayed positive and negative couplings new analysis about synchronization transitions improves knowledge of physical biological systems influenza vaccination among college and university students impact on influenzalike illness health care use and impaired school performance flu vaccine linked to reduced illness impairment of academic performance among college students factors influencing u.s. consumer support for genetic modification to prevent crop disease famine fear won t sway minds on gm crops soluble cd is a novel marker of systemic congestion in heart failure patients an experimental mechanistic and transcardiac clinical study novel tests improve treatment for heart failure patients induced sensorimotor brain plasticity controls pain in phantom limb patients cause of phantom limb pain in amputees and potential treatment identified a three drug nanoscale drug delivery system designed for preferential lymphatic uptake for the treatment of metastatic melanoma nanotech drug delivery shows promise for improved melanoma treatment the formation and evolution of titan s winter polar vortex unexpected atmospheric vortex behavior on saturn s moon titan education on the digital terrain a case study exploring college athletes perceptions of social media training social media training works best for student athletes study shows context dependent medicinal effects of anabasine and infection dependent toxicity in bumble bees no natural medicine in once promising compound study of bee health finds bitter melon reduces head and neck squamous cell carcinoma growth by targeting c met signaling bitter melon extract may have potential to fight head neck cancer predicting the spread of the asian hornet vespa velutina following its incursion into great britain asian hornet to colonize uk within two decades without action identification of key films and personalities in the history of cinema from a western perspective the wizard of oz most influential film of all time according to network science broadly neutralizing antibodies from human survivors target a conserved site in the ebola virus glycoprotein hr mper region new breakthrough paving the way for universal ebola therapeutic long term suppression of atrial fibrillation by botulinum toxin injection into epicardial fat pads in patients undergoing cardiac surgery three year follow up of a randomized study botulinum toxin shows promise in trials to reduce post operative atrial fibrillation poaf in cardiac surgery patients brca deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny novel role of brca in regulating the survival of skin stem cells identified the relationship between sea level and climate forcing by co on geological timescales natural relationship between carbon dioxide concentrations and sea level documented authorization framework for secure cloud assisted connected cars and vehicular internet of things framework to stop cyber attacks on internet connected cars verification of argentine ant defensive compounds and their behavioral effects on heterospecific competitors and conspecific nestmates for global invasion argentine ants use chemical weapons intoxication with bourbon versus vodka effects on hangover sleep and next day neurocognitive performance in young adults bourbon versus vodka bourbon hurts more the next day due to byproducts of fermenting process prediction of psychosis across protocols and risk cohorts using automated language analysis speech analysis software predicted psychosis in at risk patients with up to percent accuracy eight millennia of matrilineal genetic continuity in the south caucasus genetic evidence from the south caucasus region shows surprising long term stability modifiable determinants of serum hydroxyvitamin d status in early childhoodopportunities for preventiondeterminants of early childhood vitamin d status supplements and cow s milk play biggest roles in determining vitamin d levels in children manic fringe deficiency imposes jagged addiction to intestinal tumor cells key piece identified for slowing a colorectal cancer subtype attribution of high risk human papillomavirus genotypes to infection and cervical disease preventing cervical cancer new vaccine against hpv infections imminent effects of short term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines glucocorticoid treatment may prevent long term damage to joints study shows impact of interactive online units on learning science among students with learning disabilities and english learners web based teaching can improve science understanding for struggling pupils ultrasensitive detection of unknown colon cancer initiating mutations using the example of the adenomatous polyposis coli gene new method for early detection of colon cancer explorative learning and functional inferences on a five step means means end problem in goffin s cockatoos cacatua goffini cockatoos pick puzzle box locks cockatoos show technical intelligence on a five lock problem chronic obstructive pulmonary disease and lipid core carotid artery plaques in the elderly the rotterdam study high risk carotid artery plaque formation is increased in older copd patients supplementation increases amyloid phagocytosis and resolvin d in patients with minor cognitive impairment omega supplements antioxidants may help with preclinical alzheimer s disease autonomous functional movements in a tendon driven limb via limited experience a robotic leg born without prior knowledge learns to walk wearable silver nanowire dry electrodes for electrophysiological sensing wearable sensor clears path to long term ekg emg monitoring prevalence of fetal alcohol spectrum disorder among special sub populations a systematic review and meta analysis fetal alcohol spectrum disorder prevalence is very high in susceptible groups worldwide reconstructing past species assemblages reveals the changing patterns and drivers of extinction through time extinction risk factors for new zealand birds today differ from those of the past mood and personality interact to determine cognitive biases in pigs a pig s life how mood and personality affect the decisions of domestic pigs urbanization exacerbated the rainfall and flooding caused by hurricane harvey in houston houston s urban sprawl increased rainfall flooding during hurricane harvey secreted klotho isoform protects against age dependent memory deficits gene therapy protects against age related cognitive memory deficits flight mode affects allometry of migration range in birds migration ranges of flying birds depend on body size and flight style envelope deglycosylation enhances antigenicity of hiv gp epitopes for both broad neutralizing antibodies and their unmutated ancestor antibodies new hiv vaccine approach targets desirable immune cells effect of standard vs. dose escalated radiation therapy for patients with intermediate risk prostate cancer the nrg oncology rtog randomized clinical trial. higher doses of radiation don t improve survival in prostate cancer pharmacological targeting of csf r inhibits microglial proliferation and prevents the progression of alzheimer s like pathology beneficial effects of blocking brain inflammation in an experimental model of alzheimer s problem solving ability and response to novelty in mountain chickadees poecile gambeli from different elevations being better problem solvers helps mountain chickadees survive at higher altitudes effect on survival of longer intervals between confirmed diagnosis and treatment initiation among low income women with breast cancer delayed treatment for advanced breast cancer has profound effect measuring hospital quality using pediatric readmission and revisit rates pediatric readmission rates aren t indicator of hospital performance study shows electronic cigarette use by youth prevalence correlates and use trajectories from middle to high school high use of electronic cigarettes seen in th th graders in oregon gene therapy for type diabetes mellitus in rats by gastrointestinal administration of chitosan nanoparticles containing human insulin gene novel attempt of gene therapy for type diabetes mellitus optical refractive index sensors with plasmonic and photonic structures promising and inconvenient truth novel framework for tracking developments in optical sensors femoral nerve block vs periarticular bupivacaine liposome injection after primary total knee arthroplasty effect on patient outcomes method of postoperative pain relief may influence recovery from total knee replacement surgery a cluster randomised controlled effectiveness trial evaluating perinatal home visiting among south african mothers infants south african mentor mothers improve perinatal health outcomes potential of golden potatoes to improve vitamin a and vitamin e status in developing countries golden potato delivers bounty of vitamins a and e risk of infection in type and type diabetes compared with the general population a matched cohort study people with diabetes face increased risk of infections unique signatures of long noncoding rna expression in response to virus infection and altered innate immune signaling new player in innate immunity ? class of biomolecules triggered in response to respiratory virus infection lifestyle factors and mortality risk in individuals with diabetes mellitus are the associations different from those in individuals without diabetes ? diet lifestyle advice for those with diabetes should be no different from that for general public ercc l mutations link a distinct bone marrow failure syndrome to dna repair and mitochondrial function new disease gene discovery sheds light on cause of bone marrow failure results of a regional effort to improve warfarin management new approach to managing warfarin patients improves care cuts costs assessment of using fingerstick blood sample with i stat point of care device for cardiac troponin i assay use of fingerstick blood sample with i stat point of care device the value of family history as a risk indicator for venous thrombosis family history associated with increased risk of blood clots cervical screening at age years and the risk of cervical cancer at age years and older population based case control study cervical screening up to age may prevent cervical cancer in older women genetic and environmental effects on same sex sexual behaviour a population study of twins in sweden society s attitudes have little impact on choice of sexual partner cyclic amp stimulates neurite outgrowth of lamprey reticulospinal neurons without substantially altering their biophysical properties research sheds light on nerve regeneration following spinal cord injury leisure time computer use and adolescent bone health findings from the tromso study fit futures a cross sectional study weekend screen time linked to poorer bone health in teen boys a prospective study of concussions among national hockey league players during regular season games the nhl nhlpa concussion program professional hockey days lost per concussion in nhl increasing a hierarchical retinotopic proto organization of the primate visual system at birth blueprint for adult visual system is present at birth the retinotopic organization of striate cortex is well predicted by surface topology universal map of vision in the human brain improved color constancy in honey bees enabled by parallel visual projections from dorsal ocelli seeing the colored light bee brains open way for better cameras the influence of pressure on crude oil biodegradation in shallow and deep gulf of mexico sediments deepwater horizon oil spill oil biodegradation inhibited in deep sea sediments chemoprevention of nonmelanoma skin cancer with celecoxib a randomized double blind placebo controlled trial widely used arthritis pill protects against skin cancer study suggests seventeen new genera of microgastrine parasitoid wasps hymenoptera braconidae from tropical areas of the world new wasps named after crocodile dundee and toblerone amongst new genera and species global surgery a roadmap for high income country actors ditch colonial thinking to boost access to surgery for world s poor rich nations told altered primary chromatin structures and their implications in cancer development altered primary chromatin structures implications in cancer development obesity in early adulthood as a risk factor for psoriatic arthritis obesity in early adulthood associated with increased risk of psoriatic arthritis reindeer vision explains the benefits of a glowing nose the scientific benefits of rudolph s red nose processing and evaluation of bioactive coatings on polymeric implants researchers coat spinal polymer implants with bioactive film to improve bonding with bone reach and grasp by people with tetraplegia using a neurally controlled robotic arm people with paralysis control robotic arms to reach and grasp using brain computer interface generation of functional human pancreatic cells in vitro giant leap for diabetes from human embryonic stem cells to billions of human insulin producing cells independent review of social and population variation in mental health could improve diagnosis in dsm revisions examine social factors to explain rise in diagnoses of mental disorders increasing the sugar concentration in tomato fruit juice by coiling wire around plant stems increasing sugar concentration in tomato juice found by researchers microrna a engineered mesenchymal stem cells augment cardiac function and cell survival in the infarct heart bioengineered patch molecular booster could improve stem cells ability treat heart failure using an epidemiological model for phylogenetic inference reveals density dependence in hiv transmission better understanding of hiv epidemic through evolutionary lens in planta changes in protein phosphorylation induced by the plant hormone abscisic acid plants give up some deep secrets of drought resistance global regional and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in a systematic review and modelling study experts urge action to cut child deaths from deadly lung virus origin of spatial variation in us east coast sea level trends during why is sea level rising faster in some places along the us east coast than others ? images of internal tides near the norwegian continental slope first study to show that seismic imaging detects ocean s internal tides an alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis gateway enzyme for chemicals from catnip to cancer drug discovered postmenopausal weight change and incidence of fracture post hoc findings from women s health initiative observational study and clinical trials both weight loss weight gain linked with increased fracture risk use of a smartphone tablet based bidirectional telemedicine disease management program facilitates early detection and treatment of copd exacerbation symptoms app facilitates early detection treatment of copd exacerbation symptoms the year relationship between cholesterol and dementia from midlife to late life high cholesterol in middle age women not a risk factor for alzheimer s and other dementias study finds species delimitation with gene flow a methodological comparison and population genomics approach to elucidate cryptic species boundaries in malaysian torrent frogs black box methods used by biologists probably overestimate number of new species bitcoin emissions alone could push global warming above c bitcoin can push global warming above degrees c in a couple decades high fidelity multimode fibre based endoscopy for deep brain in vivo imaging insight into the brain s hidden depths scientists develop minimally invasive probe sustainability and tourism the effect of the united states first offshore wind farm on the vacation rental market offshore wind farm increased tourism on block island lecanorchis tabugawaensis orchidaceae vanilloideae a new mycoheterotrophic plant from yakushima island japan plants cheat too a new species of fungus parasitizing orchid exacerbated fires in mediterranean europe due to anthropogenic warming projected with non stationary climate fire models global warming increases wildfire potential damages in mediterranean europe macrophage derived il mediates mucosal repair by epithelial wisp signaling immune cells produce wound healing factor could lead to new ibd treatment it is not just folklore the aqueous extract of mung bean coat is protective against sepsis bean used in chinese food could protect against sepsis smoking and physical activity explain the increased mortality risk following marital separation and divorce evidence from the english longitudinal study of ageing smoking lack of exercise linked to early death after divorce the nlrp inflammasome may contribute to pathologic neovascularization in the advanced stages of diabetic retinopathy new tools in the fight against diabetic blindness preferred listening levels of personal listening devices in young teenagers self reports and physical measurements using mp players at high volume puts teens at risk for early hearing loss say researchers exploring the effect of companion robots on emotional expression in older adults with dementia a pilot randomized controlled trial robo pets may contribute to quality of life for those with dementia the role of adverse childhood experiences as determinants of non suicidal self injury among children and adolescents referred to community and inpatient mental health settings direct and not indirect childhood abuse linked to non suicidal self injury in adolescents schwann cell lrp regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain pinning down the pain schwann cell protein plays major role in neuropathic pain regional groundwater flow and accumulation of a massive evaporite deposit at the margin of the chilean altiplano exploring one of the largest salt flats in the world prenatal surgery for myelomeningocele and the need for cerebrospinal fluid shunt placement scan may identify best candidates for fetal spina bifida surgery diverse tetrapod trackways in the lower pennsylvanian tynemouth creek formation near st. martins southern new brunswick canada ancient reptiles make tracks discovery of fossilized footprints reveals when reptiles first conquered dry land severe asthma in children insights from the national heart lung and blood institute s severe asthma research program research and insights on severe asthma in children improving crispr cas nuclease specificity using truncated guide rnas shortening guide rna markedly improves specificity of crispr cas nucleases impacts of huanglongbing symptom severity on fruit detachment force and mechanical properties of sweet oranges citrus sinensis how huanglongbing affects oranges detachment force fruit properties is the consumption of fast foods associated with asthma or other allergic diseases ? linked between consumption of fast food and asthma other allergic diseases comparative analysis of human embryonic stem cell and induced pluripotent stem cell derived hepatocyte like cells reveals current drawbacks and possible strategies for improved differentiation induced pluripotent stem cells from fetal skin cells and embryonic stem cells display comparable potential for derivation of hepatocytes traumatic brain injury paraquat exposure and their relationship to parkinson disease head injury and pesticide exposure leads to triple the risk of parkinson s disease a phosphomimetic mutation stabilizes sod and rescues cell viability in the context of an als associated mutation new als discovery scientists reverse protein clumping involved in neurodegenerative conditions a selective microrna based strategy inhibits restenosis while preserving endothelial function selective therapy may improve artery repair after interventional cardiovascular procedures recovery of phospho erk activity allows melanoma cells to escape from braf inhibitor therapy fda approval of revolutionary two drug combo to treat advanced melanoma becoming more like your mate hormonal similarity reduces divorce rates in a wild songbird hormonal similarity makes happy couples at least in birds lymphatic vessels arise from specialized angioblasts within a venous niche resolving a lymphatic riddle researchers to grow for the first time lymphatic cells in the lab dna barcode reference library for iberian butterflies enables a continental scale preview of potential cryptic diversity first genetic atlas of butterflies of the iberian peninsula soil analysis in discussions of agricultural feasibility for ancient civilizations a critical review and reanalysis of the data and debate from chaco canyon new mexico ancestral people of chaco canyon likely grew their own food dual pd lag immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia efficient control of leukemia with treatment by dual immune checkpoint blockade the diet of the first europeans from atapuerca new evidence on the diet of the homo antecessor from atapuerca p improves ad like pathology by increasing autophagy critical protein shows promise for the treatment of alzheimer s disordered social media use and risky drinking in young adults differential associations with addiction linked traits do personality traits of compulsive users of social media overlap with problem drinking ? evaluating hiv prevention strategies for populations in key affected groups the example of cabo verde case study cabo verde simulation offers policy rx for curbing hiv functional integrity in children with anoxic brain injury from drowning structural and functional mri in children resuscitated after drowning pinpoints site of anoxic brain injury sustainable heat extraction from abandoned mine tunnels a numerical model mining for heat abandoned mine tunnels might ferry geothermal energy from deep underground why men should be included in research on binge eating results from a comparison of psychosocial impairment in men and women study shows why underrepresented men should be included in binge eating research neural responses to visual food stimuli after a normal vs. higher protein breakfast in breakfast skipping teens a pilot fmri study eat a protein rich breakfast to reduce food cravings prevent overeating later researcher finds tropism and innate host responses of the pandemic h n influenza virus in ex vivo and in vitro cultures of human conjunctiva and respiratory tract of swine birds and humans pandemic h n flu school based strategies to reduce suicidal ideation suicide attempts and discrimination among sexual minority and heterosexual adolescents in western canada gay straight alliances in schools reduce suicide risk for all students adverse maternal and perinatal outcomes in pregnant women with sickle cell disease systematic review and meta analysis pregnancy complications in women with sickle cell disease naturally occurring neomorphic pik r mutations activate the mapk pathway dictating therapeutic response to mapk pathway inhibitors endometrial colon cancers study indicates possible new way to treat perioperative myocardial injury after noncardiac surgery incidence mortality and characterization higher risk of dying due to heart cell damage without any symptoms occurs during or after non heart surgery single neuron correlates of atypical face processing in autism neurons in face recognition center respond differently in autistic brain cd lymphoid tissue inducer cells promote innate immunity in the gut border patrol immune cells protect body from invaders urban parks refuges for tropical butterflies in southeast asia ? can butterflies cope with city life ? butterfly diversity in kuala lumpur parks optimization of complex cancer morphology detection using the sivq pattern recognition algorithm software for analyzing digital pathology images proving its usefulness intestinal microbiome is related to lifetime antibiotic use in finnish pre school children antibiotic use in early life disrupt normal gut microbiota development no beneficial effects of pine bark extract on cardiovascular disease risk factors pine bark extract has no effect on blood pressure study finds chronic adolescent marijuana use as a risk factor for physical and mental health problems in young adult men. teen marijuana use not linked to later depression lung cancer other health problems study finds common genetic determinants of vitamin d insufficiency a genome wide association study common gene variants appear to increase risk of vitamin d deficiency wireless battery free flexible miniaturized dosimeters monitor exposure to solar radiation and to light for phototherapy world s smallest wearable device warns of uv exposure enables precision phototherapy microglia and amyloid precursor protein coordinate control of transient candida cerebritis with memory deficits fungi cause brain infection and impair memory in mice pivotal advance bifidobacteria and gram negative bacteria differentially influence immune responses in the proinflammatory milieu of celiac disease gut bacteria offer new insights and hope for people with celiac disease a multivariate additive noise model for complete causal discovery beyond superstition to general causality ai nutcracker for real world problems advertisement prevalence of major risk factors and use of screening tests for cancer in the united states cancer prevention efforts in the us a mixed bag predictors of child to parent aggression a year longitudinal study narcissism the seed of violence from children towards their parents large mammal population declines in africa s protected areas africa s national parks hit by mammal declines wolbachia influences the production of octopamine and affects drosophila male aggression infection with wolbachia bacteria curbs fighting among fruit flies sixth grade boys perceived benefits of and barriers to physical activity and suggestions for increasing physical activity lack of motivation equipment main barriers for exercise for boys influence of point of sale tobacco displays and graphic health warning signs on adults evidence from a virtual store experimental study policies banning tobacco displays may deter adult smoking graphic health warning sign at point of sale might not the use of a self directed learning program to provide introductory training in pivotal response treatment to parents of children with autism distance education for parents of children with autism found effective temporal and strain specific host microrna molecular signatures associated with swine origin h n and avian origin h n influenza a virus infection genetic regulators hijacked by avian and swine flu viruses identified cerebral organoids model human brain development and microcephaly mini human brains created scientists grow human brain tissue in d culture system phylogeny and historical biogeography of true morels morchella reveals an early cretaceous origin and high continental endemism and provincialism in the holarctic genetic analysis reveals history evolution of an ancient delicacy morels pediatric eye injuries due to nonpowder guns in the united states children s eye injuries from nonpowder guns on the rise transmission dynamics of re emerging rabies in domestic dogs of rural china interventions in dog populations could reduce rabies in rural china signal transduction controls heterogeneous nf b dynamics and target gene expression through cytokine specific refractory states research brings new understanding of chronic inflammatory disease variation in the reproductive strategy of a lichenized fungus along a climatic gradient lichen that changes its reproductive strategy according to the climate gestational weight gain and risk of infant death in the united states inadequate pregnancy weight gain a risk factor for infant mortality inhibitory control but not prolonged object related experience appears to affect physical problem solving performance of pet dogs inhibitory control may affect physical problem solving in pet dogs cord blood monocyte derived inflammatory cytokines suppress il and induce nonclassic th type immunity associated with development of food allergy food allergy linked to hyperactive immune system at birth speech disturbs face scanning in month old infants who develop autism spectrum disorder early autism detection speech disrupts facial attention in month old infants who later develop autism the sirt activator srt extends lifespan and improves health of mice fed a standard diet supplement added to standard diet improves health prolongs life in mice a randomized double blind placebo controlled trial of low dose sertraline in young children with fragile x syndrome sertraline brand named zoloft improves functioning in young children with fragile x large scale climatic and geophysical controls on the leaf economics spectrum rule breaker forests in andes amazon revealed by remote spectral sensing pellet fed gasifier stoves approach gas stove like performance during in home use in rwanda field study finds pellet fed stoves cut air pollutant emissions biological clinical and population relevance of loci for blood lipids sorting out the genetic and biological links between cholesterol and coronary heart disease practices predictors and consequences of expressed breast milk feeding in healthy full term infants new moms moving toward pumped milk in a bottle impulsiveness and insula activation during reward anticipation are associated with genetic variants in gabra in a family sample enriched for alcoholism scientists explore new link between genetics alcoholism and the brain women have lower chances than men to be resuscitated and survive out of hospital cardiac arrest women are less likely to be resuscitated and survive a cardiac arrest than men can consumers willingness to pay incentivize adoption of environmental impact reducing technologies in meat animal production ? food labels can reduce livestock environmental impacts study shows latent structure in random sequences drives neural learning toward a rational bias committing gamblers fallacy may be in the cards new research shows dna based self assembly of chiral plasmonic nanostructures with tailored optical response tailored optical material from dna light modifying nanoparticles automated deep neural network surveillance of cranial images for acute neurologic events artificial intelligence platform screens for acute neurological illnesses effects of ozone nano bubble water on periodontopathic bacteria and oral cells in vitrostudies ozone nano bubble water potential treatment for severe gum infections thymic stromal lymphopoietin fosters human breast tumor growth by promoting type inflammation protein fuels inflammation in pancreatic and breast tumors the association of lifetime alcohol use with mortality and cancer risk in older adults a cohort study risks of cancer and mortality by average lifetime alcohol intake n cadherin expressing bone and marrow stromal progenitor cells maintain reserve hematopoietic stem cells scientists have identified a bone marrow backup system increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration strategy prevents blindness in mice with retinal degeneration practicing for the future deliberate practice in early childhood starting at age children spontaneously practice skills to prepare for the future rational snacking young children s decision making on the marshmallow task is moderated by beliefs about environmental reliability the marshmallow study revisited delaying gratification depends as much on nurture as on nature increased leisure time physical activity associated with lower onset of diabetes in adults with impaired fasting glucose a population based prospective cohort study physical exercise reduces risk of developing diabetes study shows two year bmi outcomes from a school based intervention for nutrition and exercise a randomized trial middle school intervention program leads to long term bmi reduction for obese students a new milky way satellite discovered in the subaru hyper suprime cam survey record breaking faint satellite galaxy of the milky way discovered evidence of marine mammal predation of the european eel anguilla anguilla l. on its marine migration threatened eels disappear in the deep ocean on their way to the sargasso sea algae drive enhanced darkening of bare ice on the greenland ice sheet algae growth reduces reflectivity enhances greenland ice sheet melting nucleoside modified mrna immunization elicits influenza virus hemagglutinin stalk specific antibodies candidate for universal flu vaccine protects against multiple strains enhancing food security of low income consumers an investigation of financial incentives for use at farmers markets farmers market vouchers may boost produce consumption in low income families heat acclimation improves cutaneous vascular function and sweating in trained cyclists exercising in the heat may improve athletic performance in cool and hot conditions study suggests combining laser microdissection and rna seq to chart the transcriptional landscape of fungal development a laser as mini scissors genetic activity in the entire genome of multicellular fungi analysed at a stroke rice with reduced stomatal density conserves water and has improved drought tolerance under future climate conditions rice with fewer stomata requires less water and is better suited for climate change whole genome bisulfite sequencing of cell free dna identifies signature associated with metastatic breast cancer research discovery leads to potential diagnostic for assessing breast cancer recurrence contribution of alcohol use disorders to the burden of dementia in france a nationwide retrospective cohort study largest study of its kind finds alcohol use biggest risk factor for dementia inhibition of rgma alleviates symptoms in a rat model of neuromyelitis optica efficacy of antibody targeting devic s disease proven in new animal model drosophila wnt and stat define apoptosis resistant epithelial cells for tissue regeneration after irradiation location location location cellular hotspots for tumors and regeneration insurance plan presentation and decision support on healthcare.gov and state based web sites created for the affordable care act some health insurance websites show improved efforts to support patient decision making microneedle integrated transdermal patch for fast onset and sustained delivery of lidocaine novel microneedle patch for faster effective delivery of painkiller collagen risk of pneumonia associated with incident benzodiazepine use among community dwelling adults with alzheimer disease common sedatives linked to increased risk of pneumonia in people with alzheimer s disease mitochondrial dna and temperature tolerance in lager yeasts genes behind lager yeast s cold and sugar loving success revealed do male fish prefer them big and colourful ? non random male courtship efforts in a viviparous fish with negligible paternal investment do male fish prefer them big and colorful ? ghrelin regulates the hypothalamic pituitary adrenal axis and restricts anxiety after acute stress low ghrelin reducing appetite at the cost of increased stress ? combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy combination therapy provides hope for cure of dangerous infections of cystic fibrosis patients an examination of the shift in school level clustering of us adolescent electronic cigarette use and its multilevel correlates teenage e cigarette use clustered in certain schools study finds the impact of gender stereotypes on the self concept of female students in stem subjects with an under representation of females stereotypes still affect females career aspirations in stem topics effects of nicotine patch vs varenicline vs combination nicotine replacement therapy on smoking cessation at weeks a randomized clinical trial comparison of smoking cessation therapies finds similar quit rates ninety eight new species of trigonopterus weevils from sundaland and the lesser sunda islands ninety eight new beetle species discovered in indonesia temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury how brain s memory center repairs damage from head injury site specific ubiquitylation and sumoylation using genetic code expansion and sortase labeling proteins with ubiquitin paves new road to cell regulation research complex mammalian like haematopoietic system found in a colonial chordate sea invertebrate sheds light on evolution of human blood immune systems reliability and smallest worthwhile difference of the nfl test in ncaa division i football players guideline for determining effectiveness of college football training methods would north american paleoindians have noticed younger dryas age climate changes ? ice age climate change did not pose significant challenges to first americans study suggests transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury stem cell transplant repairs damaged gut of inflammatory bowel disease spleen tyrosine kinase inhibitor tak prevents splenomegaly and tumor development in a murine model of epstein barr virus associated lymphoma experimental drug takes aim at cancers associated with epstein barr virus a psycho educational hiv sti prevention intervention for internally displaced women in leogane haiti results from a non randomized cohort pilot study hiv sti prevention program in haiti is changing and saving lives l dex ratio in detecting breast cancer related lymphedema reliability sensitivity and specificity new solution in detecting breast cancer related lymphedema comparative morphological trade offs between pre and post copulatory sexual selection in giant hissing cockroaches tribe gromphadorhini lovers or fighters species of giant cockroaches employ different strategies in the mating game the cell cycle regulator opposes and reverses cancer metabolic reprogramming can protein sigma prevent or kill breast cancer tumors ? extensive elemental mapping unlocks mg ca ratios as climate proxy in seasonal records of mediterranean limpets vast record of past climate fluctuations now available thanks to laser imaging of shells predicting multiple myeloma disease activity by analyzing natural calcium isotopic composition calcium isotope analysis used to predict myeloma progression spitsbergen s endangered bowhead whales sing through the polar night critically endangered whales sing like birds new recordings hint at rebound metal ions effectively ablate the action of botulinum neurotoxin a simple copper complex shuts down botulinum neurotoxin poisoning addressing the hiv aids epidemic among puerto rican people who inject drugs the need for a multiregion approach puerto ricans who inject drugs both in the northeast u.s. and in puerto rico among latinos at highest risk of contracting hiv potential of low dose leuco methylthioninium bis hydromethanesulphonate lmtm monotherapy for treatment of mild alzheimer s disease cohort analysis as modified primary outcome in a phase iii clinical trial alzheimer s second phase study results for tau aggregation inhibitor antibiotics overuse in animal agriculture a call to action for health care providers doctors call on hospitals to oppose the overuse of antibiotics in animal agriculture academy of nutrition and dietetics benchmarks for nutrition in child care are child care providers across contexts meeting recommendations ? passing bowls family style teaches daycare kids to respond to hunger cues fights obesity seascape models reveal places to focus coastal fisheries management opportunity to restore abundance to hawaiian reef fisheries working and episodic memory in hiv infection alcoholism and their comorbidity baseline and year follow up examinations hiv infection and chronic drinking have a synergistic damaging effect on the brain immunological profiling of tuberculosis associated immune reconstitution inflammatory syndrome and non immune reconstitution inflammatory syndrome death in hiv infected adults with pulmonary tuberculosis starting antiretroviral therapy a prospective obse immune biomarkers help predict early death complications in hiv patients with tb transcriptional control of amino acid homeostasis is disrupted in huntington s disease new evidence how amino acid cysteine combats huntington s disease elephant poaching track the impact of kenya s ivory burn measuring impact of kenya s ivory burning urgent diagnosis of multiple sclerosis revisions of the mcdonald criteria revised mcdonald criteria expected to speed the diagnosis of multiple sclerosis natural selection reduced diversity on human y chromosomes study dispels theories of y chromosome s demise stripped down chromosome retains key genes for fertility a simplified approach to measuring national gender inequality new measure of equality reveals a fuller picture of male well being empowering women and improving female reproductive health through control of neglected tropical diseases improving female reproductive health and empowerment through control of ntds ocean acidification effects on atlantic cod larval survival and recruitment to the fished population ocean acidification threatens cod recruitment in the atlantic tweak mediates inflammation in experimental atopic dermatitis and psoriasis potential target for treatment of skin inflammation in eczema and psoriasis association between sentinel lymph node excision with or without preoperative spect ct and metastatic node detection and disease free survival in melanoma technique using computed tomography associated with improved detection of lymph node metastasis in patients with melanoma alterations in the elasticity pliability and viscoelastic properties of facial skin after injection of onabotulinum toxin a pliability elasticity of skin increase following wrinkle treatment with botox association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type new class of anti arthritis drugs effectively treats multiple inflammatory diseases canadian guideline on hiv pre exposure prophylaxis and nonoccupational postexposure prophylaxis new hiv guideline outlines cost effective prevention strategies for high risk people emerging adult reactions to labeling regarding age group differences in narcissism and entitlement young adults distressed by labels of narcissism entitlement spatio temporal coherence of dengue chikungunya and zika outbreaks in merida mexico dengue hot spots provide map to chikungunya and zika outbreaks saw it on facebook drank it at the bar ! effects of exposure to facebook alcohol ads on alcohol related behaviors party on line the link between social media alcohol use randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy cbd clinical trial results on seizure frequency in dogs encouraging differences in multi joint radiographic osteoarthritis phenotypes among african americans and caucasians the johnston county osteoarthritis project more african americans burdened by osteoarthritis in multiple large joints intimate partner violence and reproductive coercion global barriers to women s reproductive control access to female controlled contraception needed in intimate partner violence paleoseismic evidence for multiple m w earthquakes in the eastern tennessee seismic zone during the late quaternary evidence for past large earthquakes in the eastern tennessee seismic zone theoretical tool bridging cell polarities with development of robust morphologies single cell asymmetries control how groups of cells form d shapes together a simple method for molecular detection of swine origin and human origin influenza a virus new accurate diagnostic test for swine h n influenza using rt pcr technology age at first drink moderates the impact of current stressful life events on drinking behavior in young adults an early age at first drink combined with stressful life events can lead to heavy drinking adrenal metabolic and cardio renal dysfunction develops after pregnancy in rats born small or stressed by physiological measurements during pregnancy being born small or stress during pregnancy can lead to greater disease risk in mothers use of active surveillance or watchful waiting for low risk prostate cancer and management trends across risk groups in the united states study finds upsurge in active surveillance for low risk prostate cancer transcriptome response of human skeletal muscle to divergent exercise stimuli molecular response of muscle to different types of exercise identified should nutritional supplements and sports drinks companies sponsor sport ? a short review of the ethical concerns sporting events should ditch nutritional supps sports drinks sponsorship experts urge obesogenic diet in aging mice disrupts gut microbe composition and alters neutrophil lymphocyte ratio leading to inflamed milieu in acute heart failure high fat diet and age alter microflora and cause inflammation in heart failure an acellular biologic scaffold treatment for volumetric muscle loss results of a patient cohort study regenerative medicine improves strength function in severe muscle injuries lactoferrin acts as an adjuvant during influenza vaccination of neonatal mice infant friendly flu vaccine developed with key protein impact of changes in heart rate with age on all cause death and cardiovascular events in year old men from the general population mid life resting heart rate of plus beats minute linked to doubling in early death risk leaf cutter ants engineer large nitrous oxide hot spots in tropical forests leafcutter ants emit as much nitrous oxide as wastewater treatment tanks two hundred fifty years of reconstructed south asian summer monsoon intensity and decadal scale variability corals in the red sea offer long term view of the south asian summer monsoon randomized controlled feasibility trial of intranasal ketamine compared to intranasal fentanyl for analgesia in children with suspected extremity fractures intranasal ketamine has more minor side effects than intranasal fentanyl in children with acute pain life expectancy of persons receiving combination antiretroviral therapy in low income countries a cohort analysis from uganda hiv therapies provide near normal lifespan in africa study shows psychological resilience and the gene regulatory impact of posttraumatic stress in nepali child soldiers resilience affects whether childhood trauma results in harmful gene response pathways from neighborhood poverty to depression among older adults poverty high neighborhood murder rates increase depression in older adults total internal reflection accounts for the bright color of the saharan silver ant reflective saharan silver ant hairs thermoregulate create bright color outcomes after coronary stent implantation in patients with metal allergy coronary stents not harmful to patients with history of metal allergy study suggests the first steps of adaptation of escherichia coli to the gut are dominated by soft sweeps fighting for survival in the gut unravelling the hidden variation in bacteria endoscopy as a novel method for assessing endoparasite burdens in free ranging european shags phalacrocorax aristotelis scientists develop novel method to study parasite numbers in wild seabirds stern gerlach detection of neutral atom qubits in a state dependent optical lattice extremely accurate measurements of atom states for quantum computing myocardial infarction produces sustained proinflammatory endothelial activation in remote arteries antioxidant reduces risk for second heart attack stroke prion seeding activity and infectivity in skin samples from patients with sporadic creutzfeldt jakob disease prion protein found in skin of cjd patients policies to promote the community use of schools a review of state recreational user statutes liability issues limiting recreational use of public school facilities exposure to gestational diabetes mellitus and low socioeconomic status effects on neurocognitive development and risk of attention deficit hyperactivity disorder in offspring maternal gestational diabetes and low socioeconomic status associated with increased risk of adhd in offspring factors that contribute to differences in survival of black vs white patients with colorectal cancer insurance linked to black white survival disparities in colorectal cancer girls hidden penalty analysis of gender inequality in child mortality with data from countries gender inequality could be driving the deaths of girls under five proteogenomic characterization of human colon and rectal cancer signatures of genetic mutations in colorectal cancer discovery may advance diagnosis treatment how many lymph nodes are enough ? assessing the adequacy of lymph node yield for papillary thyroid cancer probability data could better direct lymph node removal for thyroid cancer phenotypic switch in blood effects of pro inflammatory cytokines on breast cancer cell aggregation and adhesion bioengineers discover natural switch that controls spread of breast cancer cells the histone demethylase kdm b regulates temperature dependent sex determination in a turtle species how turning down the heat makes a baby turtle male mutations in the shank synaptic scaffolding gene in autism spectrum disorder and mental retardation gene variants lead to autism and mental retardation inner structure of nerve synapses defective in patients supporting japanese mothers of children with adhd cultural adaptation of the new forest parent training programme new behavioral therapy to support japanese mothers of children with adhd comt modifies alpha tocopherol effects in cancer prevention gene supplement interactions in two randomized clinical trials genetics may influence the effects of vitamin e on cancer risk molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain study revises the development evolutionary origin of the vertebrate brain autonomous vehicles require socio political acceptance an empirical and philosophical perspective on the problem of moral decision making should ethics or human intuition drive the moral judgments of driverless cars ? an intracellular transcriptomic atlas of the giant coenocyte caulerpa taxifolia structure of world s largest single cell is reflected at the molecular level the antibody aducanumab reduces a plaques in alzheimer s disease antibody reduces harmful brain amyloid plaques in alzheimer s patients central precocious puberty caused by mutations in the imprinted genemkrn genetic mutation inherited from father s side linked to early puberty early parental loss and depression history associations with recent life stress in major depressive disorder sweating the small stuff early adversity prior depression linked to high sensitivity to stress associations between physical activity and asthma eczema and obesity in children aged an observational cohort study teens keep active despite asthma or eczema study finds differences in white matter fiber tract development present from to months in infants with autism brain imaging differences evident at months in high risk infants who later develop autism sustained response and prevention of damage progression in patients with neonatal onset multisystem inflammatory disease nomid treated with anakinra drug halts organ damage in inflammatory genetic disorder study suggests risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients widely used cancer drug associated with significantly increased risk of blood clots risk factors for scald injury in children under years of age a case control study using routinely collected data toddlers from socially deprived homes most at risk of scalds study finds effect of mistimed eating patterns on breast and prostate cancer risk mcc spain study early supper associated with lower risk of breast and prostate cancer de novo coding variants are strongly associated with tourette disorder first clear cut risk genes for tourette disorder revealed identification of cyst nematode b type cle peptides and modulation of the vascular stem cell pathway for feeding cell formation researchers discover a new link to fight billion dollar threat to soybean production public health benefits from pictorial health warnings on us cigarette packs a simsmoke simulation graphic pictures on cigarette packs would significantly reduce smoking death rate randomized trial of stent versus surgery for asymptomatic carotid stenosis stenting as effective as endarterectomy for preventing strokes in asymptomatic patients study suggests a moderating role for gender in racial ethnic disparities in alcohol services utilization results from the to national alcohol surveys alcohol programming outreach is especially important for female black latina drinkers climate degradation and extreme icing events constrain life in cold adapted mammals warming arctic climate constrains life in cold adapted mammals cognitive impairment years before clinical diagnosis of alzheimer disease dementia low scores on memory and thinking tests may signal alzheimer s years prior to disease stable hydrogen isotopes identify leapfrog migration degree of connectivity and summer distribution of golden eagles in eastern north america migratory patterns of eastern golden eagle population revealed deconstructing olfactory stem cell trajectories at single cell resolution sniffing out stem cell fates in the nose a compositional tipping point governing the mobilization and eruption style of rhyolitic magma chemical tipping point of magma determines explosive potential of volcanoes protective effect of coffee consumption on all cause mortality of french hiv hcv co infected patients three or more cups of coffee daily halves mortality risk in patients with both hiv hcv changes in concentrations of perfluorinated compounds polybrominated diphenyl ethers and polychlorinated biphenyls in norwegian breast milk during twelve months of lactation environmental contaminants in breast milk decrease over lactation time who has access to urban vegetation ? a spatial analysis of distributional green equity in us cities lack of fair access to urban green spaces human longevity genetic loci associated in uk biobank participants number of genetic markers linked to lifespan triples media s role in broadcasting acute stress following the boston marathon bombings prolonged viewing of boston marathon bombings media coverage tied to acute stress global economic burden of chagas disease a computational simulation model new study highlights chagas disease as a growing health and socio economic challenge prostate specific antigen failure and risk of death within comorbidity subgroups among men with unfavorable risk prostate cancer treated in a randomized trial psa failure predicts risk of death only in healthy men hormonal contraceptive use and women s risk of hiv acquisition a meta analysis of observational studies study supports link between injectable hormonal contraceptive and hiv risk from the cover regulatory functions of limbic y receptors in body weight and anxiety uncovered by conditional knockout and maternal care maternal care influences brain chemistry into adulthood animal study shows a comparison of the full and short scar face lift incision techniques in multiple sets of identical twins full incision facelift superior to short scar in neck region study in multiples shows video game intervention for sexual risk reduction in minority adolescents randomized controlled trial video game boosts sex health iq and attitudes in minority teens conservation implications of omitting narrow ranging taxa from species distribution models now and in the future near extinct african amphibians invisible under climate change simple technologies and diverse food strategies of the late pleistocene and early holocene at huaca prieta coastal peru ancient peru major discovery of early human life self efficacy and risk of persistent shoulder pain results of a classification and regression tree cart analysis positive self belief key to recovery from shoulder pain the diagnosis of cushing s syndrome an endocrine society clinical practice guideline experts recommend tumor removal as first line treatment for cushing s syndrome developmental biology support mothers to secure future public health give future generations a chance support mothers to secure future public health randomized comparison of universal and targeted hiv screening in the emergency department more support for universal hiv screening in emergency departments identification of diverse astrocyte populations and their malignant analogs vital links between brain tumors and epileptic seizures identifying a first order phase transition in neutron star mergers through gravitational waves how cosmic events give insight into fundamental properties of matter sex differences in the association between measures of general and central adiposity and the risk of myocardial infarction results from the uk biobank higher waist and hip measures may add up to greater risk for heart attack among women phototactic guidance of a tissue engineered soft robotic ray the debut of a robotic stingray powered by light activated rat cells exposure to low ph reduces survival and delays development in early life stages of dungeness crab cancer magister ocean acidification puts nw dungeness crab at risk impact of generalized anxiety disorder gad on prehospital delay of acute myocardial infarction patients. findings from the multicenter medea study anxiety as a protective factor after a heart attack a small molecule mitigates hearing loss in a mouse model of usher syndrome iii first small molecule targeted therapy to mitigate hearing loss in usher syndrome type genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy ancient egyptians to modern humans coronary artery disease genes benefit reproduction mental health of protective services workers results from the national epidemiologic survey on alcohol and related conditions police and firefighters at higher risk for mental disorders following traumatic events gene regulation by translational inhibition is determined by dicer partnering proteins discovery holds promise for gene therapy and agriculture genetic mechanism of plants environmental adaptability genomic analysis of year old cultivated grain illuminates the domestication history of barley genome of year old barley grains sequenced for first time a human genome wide loss of function screen identifies effective chikungunya antiviral drugs an old new weapon against emerging chikungunya virus face inversion reduces the persistence of global form and its neural correlates research turns the world upside down new study examines brain processes behind facial recognition cobra ha elicits hemagglutination inhibition antibodies against a panel of h n influenza virus co circulating variants. new broadly protective vaccines for h n influenza six plant extracts delay yeast chronological aging through different signaling pathways six new groups of molecules could be the key to delaying aging house to house human movement drives dengue virus transmission tracking spread of dengue fever domestic networks drive rapid transmission of human infection microfluidic squeezing for intracellular antigen loading in polyclonal b cells as cellular vaccines microfluidic cell squeezing device opens new possibilities for cell based vaccines million fold decrease in polymer moisture permeability by a graphene monolayer graphene infused packaging is a million times better at blocking moisture association of persistent postconcussion symptoms with pediatric quality of life how is health related quality of life for kids with postconcussion symptoms ? fat mass limits lower extremity relative strength and maximal walking performance in older women overweight older women have less leg strength power prolactin increases smn expression and survival in a mouse model of severe spinal muscular atrophy via the stat pathway pregnancy hormone has unprecedented powerful effect on spinal muscular atrophy effects of hour time restricted feeding on body weight and metabolic disease risk factors in obese adults a pilot study daily fasting works for weight loss finds report on diet temperature explains broad patterns of ross river virus transmission temperature model predicts regional and seasonal virus transmission by mosquitoes prehistoric mitochondrial dna of domesticate animals supports a th century exodus from the northern us southwest ancient dna used to track mesa verde exodus in th century mortality risk reductions for replacing sedentary time with physical activities replacing sitting time with physical activity associated with lower risk of death year round influenza immunisation during pregnancy in nepal a phase randomised placebo controlled trial year round flu vaccinations promote healthier infants in subtropics a functional assay based procedure to classify mismatch repair gene variants in lynch syndrome personalized medicine tool for inherited colorectal cancer syndrome the role of atmospheric conditions in the seasonal dynamics of north american migration flyways citizen scientists map flyways of north american birds dna methylation age of blood predicts all cause mortality in later life dna clock helps to get measure of people s lifespans risk factors methods and timing of suicide attempts among us army soldiers study examines suicide attempt risk factors methods and timing related to deployment among active duty soldiers head impact exposure measured in a single youth football team during practice drills exposure to head impacts in youth football practice drills recurrent wound botulism among injection drug users in california study examines recurrent wound botulism in injection drug users association of spinal manipulative therapy with clinical benefit and harm for acute low back pain spinal manipulation treatment for low back pain associated with modest improvement in pain function neonatal bisphenol a exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin releasing hormone neurons reproductive health effects found from low doses of bisphenol a a prospective cohort study of adolescents memory performance and individual brain dose of microwave radiation from wireless communication mobile phone radiation may affect memory performance in adolescents study finds competing risk analysis of esrd and death among patients with type diabetes and macroalbuminuria competing risks analysis highlights new targets in preventing esrd and death of diabetics filial anxiety and sense of obligation among offspring of holocaust survivors intergenerational trauma evident in offspring caring for holocaust survivor parents maya healers conception of cancer as revealed by comparison with western medicine maya healers conception of cancer may help bridge gap in multicultural settings care sexuality and body image following treatment for early stage vulvar cancer a qualitative study most women undergoing conservative surgery for vulvar cancer maintain healthy body image and sex life west nile virus infection causes endocytosis of a specific subset of tight junction membrane proteins researchers moving towards ending threat of west nile virus the diverging trajectories of cannabis and tobacco policies in the united states reasons and possible implications why the marijuana and tobacco policy camps are on very different paths epidemiology of autism spectrum disorders in adults in the community in england study estimates rate of autism spectrum disorder in adults in england genomic analysis reveals selection for asian genes in european pigs following human mediated introgression asian genes in european pigs result in more piglets depletion of coagulation factor xii ameliorates brain pathology and cognitive impairment in alzheimer s disease mice changes in the vascular system may trigger alzheimer s disease effect of a dietary portfolio of cholesterol lowering foods given at levels of intensity of dietary advice on serum lipids in hyperlipidemia a randomized controlled trial diet that combines cholesterol lowering foods results in greater decrease in ldl than low saturated fat diet study finds vegf vascular endothelial growth factor functionalized magnetic beads in a microfluidic device to improve the angiogenic balance in preeclampsia new approach uses magnetic beads to treat preeclampsia a heterologous multiepitope dna prime recombinant protein boost immunisation strategy for the development of an antiserum against micrurus corallinus coral snake venom a synthetic biology approach for a new antidote to coral snake venom cosmology from cosmic shear power spectra with subaru hyper suprime cam first year data hyper suprime cam survey maps dark matter in the universe worldwide health effects of the fukushima daiichi nuclear accident global health impacts of the fukushima nuclear disaster treatment of acute otitis media in children under years of age antibiotics best treatment for ear infections in toddlers study finds chiral majorana fermion modes in a quantum anomalous hall insulator superconductor structure evidence for the majorana fermion a particle that s its own antiparticle associations between potentially modifiable risk factors and alzheimer disease a mendelian randomization study genetically predicted higher blood pressure linked to antihypertensive use and lower alzheimer s risk ocular consequences of bottle rocket injuries in children and adolescents bottle rockets can cause serious eye injuries in children women recover faster than men after standard knee arthroplasty men play post op catch up study shows women make more progress early on after knee replacement surgery than men mortality associated with withdrawal of life sustaining therapy for patients with severe traumatic brain injury a canadian multicentre cohort study withdrawing life support for traumatic brain injuries needs cautious approach study finds smokeless tobacco use among rural women in ne alabama female smokeless tobacco use is largely unknown by physicians hybrid chickadees are deficient in learning and memory hybrid chickadees found deficient at learning and memory c ebp thr phosphorylation signaling contributes to the development of lung injury and fibrosis in mice progression of lung fibrosis blocked in mouse model metabotropic p y receptor signalling mediates astrocytic hyperactivity in vivo in an alzheimer s disease mouse model alzheimer s disease molecular signals cause brain cells to switch into a hectic state factors associated with symptomatic rhinovirus infection in patients with copd exposure to school age children ups severity of cold infections full field broadband invisibility through reversible wave frequency spectrum control spectral cloaking could make objects invisible under realistic conditions experimental warming in the field delays phenology and reduces body mass fat content and survival implications for the persistence of a pollinator under climate change climate change linked to potential population decline in bees association of socioeconomics with prevalence of visual impairment and blindness country s prevalence of visual impairment blindness associated with level of socioeconomic develop warming seas increase cold stunning events for kemp s ridley sea turtles in the northwest atlantic factors in alarming rate of cold stranded sea turtles in cape cod bay blue light rescues mice from potentially fatal pseudomonas aeruginosa burn infection efficacy safety and mechanism of action skin soft tissue infections succumb to blue light co management approaches and incentives improve management effectiveness in the karimunjawa national park indonesia indonesian fishing communities find balance between biodiversity and development effect of gaas interfacial layer on the performance of high bandgap tunnel junctions for multijunction solar cells new connection between stacked solar cells can handle energy of suns heterogeneities in leishmania infantum infection using skin parasite burdens to identify highly infectious dogs target canine superspreaders to halt killer disease cull fewer dogs study suggests predicting potential responses to future climate in an alpine ungulate interspecific interactions exceed climate effects restricting competitors could help threatened species cope with climate change the e wave propagation index epi a novel echocardiographic parameter for prediction of left ventricular thrombus. derivation from computational fluid dynamic modeling and validation on human subjects preventing blood clots with a new metric for heart function vismodegib exerts targeted efficacy against recurrent sonic hedgehog subgroup medulloblastoma results from phase ii pediatric brain tumor consortium studies pbtc b and pbtc targeted therapy shows effectiveness against a subtype of the brain tumor medulloblastoma lysophosphatidic acid and amitriptyline signal through lpa r to reduce p glycoprotein transport at the blood brain barrier antidepressant may enhance drug delivery to the brain high magnitude head impact exposure in youth football youth football how young athletes are exposed to high magnitude head impacts cluster randomized trial of the classroom scerts intervention for elementary students with autism spectrum disorder. strategic classroom intervention can make big difference for autism students chronic traumatic encephalopathy like neuropathological findings without a history of trauma researchers report first known case of cte in patient with no known head trauma the impact of a physical activity intervention program on academic achievement in a swedish elementary school setting more physical activity improved school performance in swedish study local amplifiers of il r mediated macrophage activation promote repair in lung and liver organ signal find raises hopes of immune disorder treatments modelling nafld with human pluripotent stem cell derived immature hepatocyte like cells reveals activation of plin and confirms regulatory functions of ppar modeling nafld with human pluripotent stem cell derived immature hepatocyte like cells acute in vivo testing of a conformal polymer microelectrode array for multi region hippocampal recordings thin flexible polymers record conversations deeper in the brain with less injury risk cigarette smoking and the oral microbiome in a large study of american adults another reason to break the habit smoking alters bacterial balance in mouth collagen and heparan sulfate coatings differentially alter cell proliferation and attachmentin vitroandin vivo collagen heparan sulfate coatings alter cell proliferation attachment vagus nerve stimulation during rehabilitative training improves forelimb strength following ischemic stroke early success in new treatment for stroke recovery facile fabrication of moisture responsive graphene actuators by moderate flash reduction of graphene oxides films moisture responsive robots crawl with no external power source blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation blood clotting protein triggers immune attack on brain sedentary time and mri derived measures of adiposity in active versus inactive individuals prolonged periods of sedentary time strongly associated with amount of fat around internal organs transmission risk of two chikungunya lineages by invasive mosquito vectors from florida and the dominican republic can florida mosquitoes transmit new strains of painful chikungunya virus ? clinical effects of vinorelbine administration in the management of various malignant tumor types in dogs cases a common enemy through clinical trials veterinarian fights cancer in animals humans facial fractures in motor vehicle collisions epidemiological trends and risk factors risk of facial fractures in motor vehicle crashes decreasing it s not all about autism the emerging landscape of anti vaccination sentiment on facebook analyzing a facebook fueled anti vaccination attack it s not all about autism synergetic enhancement of light matter interaction by nonlocality and band degeneracy in zno thin films excitonic radiative decay faster than thermal dephasing in zno thin films u.s. population sequence data for autosomal str loci nist builds statistical foundation for next generation forensic dna profiling risks of breast ovarian and contralateral breast cancer for brca and brca mutation carriers family history and location of genetic fault affect risk for carriers of cancer genes synthesizing genome wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate height early menopause a genetic mouse model of human primary ovarian insufficiency might school performance grow on trees ? examining the link between greenness and academic achievement in urban high poverty schools schoolyard tree cover predicts math performance in high poverty urban schools a new quantitative d approach to imaging of structural joint disease new d imaging analysis technique could lead to improved arthritis treatment microbial modulation of energy availability in the colon regulates intestinal transit intestinal bacteria influence food transit through the gut forecasting societies adaptive capacities through a demographic metabolism model climate research needs greater focus on human populations elevated frequencies of highly activated cd t cells in hiv patients developing immune reconstitution inflammatory syndrome scientists unveil mechanisms of immune reconstitution inflammatory syndrome naloxegol for opioid induced constipation in patients with noncancer pain drug trial shows promise for treating constipation caused by pain medicines the monoamine stabilizer osu counteracts down regulated dopamine output in the nucleus accumbens of long term drinking wistar rats one step closer to a new drug for alcohol dependence attempts to prevent tongue swallowing may well be the main obstacle for successful bystander resuscitation of athletes with cardiac arrest the wrong first step to revive athletes in cardiac arrest the novel adipokine wisp associates with insulin resistance and impairs insulin action in human myotubes and mouse hepatocytes abdominal fat secretes novel adipokine promoting insulin resistance and inflammation a large scale screen for coding variants predisposing to psoriasis contribution of coding variants to psoriasis much smaller than thought the impact of lifecourse socioeconomic position on cardiovascular disease events in african americans the jackson heart study african americans at lower socioeconomic levels have increased risk of heart disease dash dietary approaches to stop hypertension diet and risk of subsequent kidney disease diet designed to lower blood pressure also reduces risk of kidney disease the composition of immune cells serves as a predictor of adaptive immunity in a cohort of to year old adults differences in individuals immune responses linked to flu vaccine effectiveness achieving effective universal health coverage and diagonal approaches to care for chronic illnesses achieving effective health care with a new approach to caring for chronic illnesses effects of interannual climate variability on tropical tree cover effects of interannual climate variability on tropical tree cover satellite data reveal how tropical ecosystems may respond to climate extremes replacing reprogramming factors with antibodies selected from combinatorial antibody libraries outside in reprogramming antibody study suggests a better way to make stem cells divergent and parallel routes of biochemical adaptation in high altitude passerine birds from the qinghai tibet plateau extreme altitude birds evolved same trait via different mutations total cerebral small vessel disease score and cognitive performance in community dwelling older adults. results from the atahualpa project memory loss and other cognitive decline linked to blood vessel disease in the brain national trends in hospitalizations for opioid poisonings among children and adolescents to hospitalizations for children teens attributed to opioid poisoning jump attention deficit hyperactivity disorder in young children predictors of diagnostic stability child adhd stimulant medication use leads to bmi rebound in late adolescence longitudinal associations among discordant sexual orientation dimensions and hazardous drinking in a cohort of sexual minority women study explores reasons behind alcohol abuse in non heterosexual women integrating chemical and genetic silencing strategies to identify host kinase phosphatase inhibitor networks that control bacterial infection fighting antibiotic resistant bacteria target human cells instead disrupting reconsolidation attenuates long term fear memory in the human amygdala and facilitates approach behavior memory activation before exposure reduces life long fear of spiders type diabetes genetic loci informed by multi trait associations point to disease mechanisms and subtypes a soft clustering analysis genomic study brings us closer to precision medicine for type diabetes cross border transport of rescue dogs may spread rabies in europe european rule changes on cross border pet transport may heighten rabies risk improvements in crop water productivity increase water sustainability and food security a global analysis improving crop per drop could boost global food security and water sustainability temperate origins of long distance seasonal migration in new world songbirds the evolution of migration ancestral songbirds headed south for the winter towards the embodiment of biosocial resistance ? how to account for the unexpected effects of antiretroviral scale up in the central african republic fighting against hiv in the central african republic the importance of perseverance controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin synthetic biology gene therapy gets under the skin testing a level of response to alcohol based model of heavy drinking and alcohol problems in year olds response to alcohol peers expectancies and coping all contribute to adolescent drinking rhinovirus induced il in asthma exacerbation drives type immunity and allergic pulmonary inflammation study finds potential new target to treat asthma attacks brought on by colds long term exercise specific neuroprotection in spinal muscular atrophy like mice exercise may protect nerve cells in spinal muscular atrophy patients molecular analysis of brca in human breast cancer cells under oxidative stress how breast cancer mutation in brca causes protein to self destruct dynamic colonization history in a rediscovered isle royale carnivore martens recolonized isle royale in the s showing island s dynamism investigation of a medieval pilgrim burial excavated from the leprosarium of st mary magdalen winchester uk leprosy strain genotyped from medieval pilgrim at uk burial site increased facial width to height ratio and perceived dominance in the faces of the uk s leading business leaders the face of success top uk male business leaders show dominant traits in their faces a mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer searching for the signature causes of brcaness in breast cancer bifunctional etalon electrode to realize high performance color filter free image sensor successful development of high performance color filter free image sensor climate vulnerability and resilience in the most valuable north american fishery industry conservation ethic proves critical to gulf of maine lobster fishery training and operation of an integrated neuromorphic network based on metal oxide memristors important step in artificial intelligence stylized letters classified by their images real time measurement of cholesterol secreted by human hepatocytes using a novel microfluidic assay real time detection of cholesterol in liver on chip cultures of human liver cells does sex really matter ? explaining intraspecies variation in ocean acidification responses climate change scientists should think more about sex composite scaffold provides a cell delivery platform for cardiovascular repair engineers patch a heart tissue engineering platform enables heart tissue to repair itself high fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects high fruit and vegetable intake linked to antioxidant status and cognitive performance in healthy subjects critical care recovery center can a geriatric model of care guide recovery of icu survivors ? critical care recovery center concept could benefit adult icu survivors of all ages molecular determinants and genetic modifiers of aggregation and toxicity for the als disease protein fus tls studies of mutated protein in lou gehrig s disease reveal new paths for drug discovery genetic analysis of novel avian a h n influenza viruses isolated from patients in china february to april could new flu spark global flu pandemic ? new bird flu strain seen adapting to mammals humans recommendations for the imaging assessment of prosthetic heart valves a report from the european association of cardiovascular imaging endorsed by the chinese society of echocardiography the inter american society of echocardiography and the brazilian first recommendations published on imaging assessment of prosthetic heart valves functional traits determine trade offs and niches in a tropical forest community sunlight in tropical forest driving force behind ecological niches of tree species systematic screen of chemotherapeutics in drosophila stem cell tumors serious side effect several fda approved anti cancer drugs induce stem cell tumors rapid eye movement sleep in relation to overweight in children and adolescents less rem sleep associated with being overweight among children and teens instrumental learning of traits versus rewards dissociable neural correlates and effects on choice character traits outweigh material benefits in assessing value others bring to us targeted ablation silencing and activation establish glycinergic dorsal horn neurons as key components of a spinal gate for pain and itch spinal cord neurons that control pain and itch relationship of phenolic composition of selected purple maize zea mays l. genotypes with their anti inflammatory anti adipogenic and anti diabetic potential phenols in purple corn fight diabetes obesity inflammation in mouse cells interactions among learning stage retention and primary motor cortex excitability in motor skill learning repetitive body movements may form long lasting motor memory fornix white matter glia damage causes hippocampal gray matter damage during age dependent limbic decline scientists shed light on processes behind age related decline in brain structures caffeine based gold i n heterocyclic carbenes as possible anticancer agents synthesis and biological properties caffeine based gold compounds are potential tools in fight against cancer alcohol induced blackouts a review of recent clinical research with practical implications and recommendations for future studies alcohol induced blackouts the last five years of research projection of seasonal influenza severity from sequence and serological data computer model for projecting severity of flu season increasing frequency of extremely severe cyclonic storms over the arabian sea birth of a storm in the arabian sea validates climate model pleistocene north african genomes link near eastern and sub saharan african human populations scientists discover genomic ancestry of stone age north africans from morocco chemosynthetic origin of c depleted dissolved organic matter in a ridge flank hydrothermal system life found thriving in porous rock deep beneath the seafloor immediate and sustained improvements in working memory after selective stimulation of nicotinic acetylcholine receptors targeting nicotine receptors to treat cognitive impairments in schizophrenia effects of prenatal cocaine exposure on early sexual behavior gender difference in externalizing behavior as a mediator prenatal cocaine exposure linked to adolescents engaging in sex by age understanding interaction effects of climate change and fire management on bird distributions through combined process and habitat models some desert birds less affected by wildfires and climate change z scheme photocatalytic water splitting on a d heterostructure of black phosphorus bismuth vanadate using visible light ultrathin black phosphorus for solar driven hydrogen economy effects of initiating moderate alcohol intake on cardiometabolic risk in adults with type diabetes red wine with dinner can improve cardiovascular health of people with type diabetes satellite telemetry reveals long distance migration in the asian great bustard otis tarda dybowskii student tracks asian bird s migration patterns recommends conservation strategies inhibition of rna lariat debranching enzyme suppresses tdp toxicity in als disease models yeast model offers clues to possible drug targets for lou gehrig s disease study shows comparative analysis of the pocillopora damicornis genome highlights role of immune system in coral evolution unique immunity genes in one widespread coral species low aerobic capacity in middle aged men associated with increased mortality rates during years of follow up low physical capacity second only to smoking as highest death risk renewable energy cooperatives as an instrument towards the energy transition in spain renewable energy cooperatives an opportunity for energy transition who is afraid of math ? two sources of genetic variance for mathematical anxiety who s afraid of math ? study finds some genetic factors multivariate searchlight classification of structural magnetic resonance imaging in children and adolescents with autism distinct features of autistic brain revealed in novel analysis of mri scans human ipsc derived cerebral organoids model cellular features of lissencephaly and reveal prolonged mitosis of outer radial glia human brain organoids offer new insight into rare developmental disease bird community shifts associated with saltwater exposure in coastal forests at the leading edge of rising sea level how sea level rise affects birds in coastal forests genome wide shrna screen revealed integrated mitogenic signaling between dopamine receptor d drd and epidermal growth factor receptor egfr in glioblastoma anti psychotic meds offer hope against brain cancer mandibulate convergence in an armoured cambrian stem chelicerate a million year old sea predator with a jackknife head medication use in us youth with mental disorders study examines psychotropic medication use among u.s. adolescents with mental disorders relative impacts of mitigation temperature and precipitation on st century megadrought risk in the american southwest megadrought risks in southwest u.s. soar as atmosphere warms efforts to reprioritise the agenda in china british american tobacco s efforts to influence public policy on secondhand smoke in china tobacco firm used extensive strategy to undermine secondhand smoke policy in china does a depression management program decrease mortality in older adults with specific medical conditions in primary care ? an exploratory analysis treating major depression in older adults with diabetes may lower risk of death platelet activating factor receptor plays a role in the pathogenesis of graft versus host disease by regulating leukocyte recruitment tissue injury and lethality new discovery may lead to effective prevention and treatment of graft versus host dsease political issues evidence and citizen engagement the case of unequal access to affordable health care big stats human stories change attitudes about global issues cognition in males and females with autism similarities and differences impact of autism may be different in men and women low temperature synthesis of stable cspbi perovskite layers for solar cells obtained by high throughput experimentation inorganic perovskite absorbers for use in thin film solar cells effects of moderate red wine consumption on liver fat and blood lipids a prospective randomized study obesity greater risk for fatty liver than moderate amounts of alcohol study suggests practical guide to direct new oral anticoagulant use for secondary stroke prevention in atrial fibrillation new blood thinners reduce atrial fibrillation stroke risk without frequent monitoring distinctions in breast tumor recurrence patterns post therapy among racially distinct populations breast cancer prognosis of african american patients may improve with administration of chemotherapy before surgery study finds respiratory symptoms after smoking cessation among college students coughing and other respiratory symptoms improve within weeks of smoking cessation climate change impacts on glaciers and runoff in tien shan central asia researchers analyze melting glaciers and water resources in central asia why aredaphniain some lakes sicker ? disease ecology habitat structure and the plankton plankton disease epidemic this year ? check the lake s shape accumulation of childhood poverty on young adult overweight or obese status race ethnicity and gender disparities long term childhood poverty contributes to young adult obesity rates circadian rhythm dysfunction a novel environmental risk factor for parkinson s disease altered circadian rhythm worsens parkinson s disease researchers show association between oral health and cognitive status a systematic review is there a link between oral health and the rate of cognitive decline ? new egyptian sauropod reveals late cretaceous dinosaur dispersal between europe and africa new egyptian dinosaur reveals ancient link between africa and europe selumetinib enhanced radioiodine uptake in advanced thyroid cancer drug shown to reverse radioiodine resistance in some advanced thyroid cancers aversive images cause less perceptual interference among violent video game players evidence from emotion induced blindness video game players frequently exposed to graphic content may see world differently a microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow new model developed to study inflammatory bowel disease in human biopsy samples marine mammal noise exposure criteria updated scientific recommendations for residual hearing effects review of noise impacts on marine mammals yields new policy recommendations synchronizing stochastic circadian oscillators in single cells of neurospora crassa technology brings new precision to study of circadian rhythm in individual cells photosynthetic seasonality of global tropical forests constrained by hydroclimate new information helps predict future climate change impacts on global tropics differential localization of glioblastoma subtype implications on glioblastoma pathogenesis clinical study suggests the origin of glioblastoma subtypes promotion of natural tooth repair by small molecule gsk antagonists natural tooth repair method using alzheimer s drug could revolutionize dental treatments plant soil feedbacks and mycorrhizal type influence temperate forest population dynamics soil fungi help tree seedlings survive influence forest diversity diel fledging patterns among grassland passerines relative impacts of energetics and predation risk mini video cameras offer peek at hard to observe bird behavior toward understanding obstetrical outcome in advanced assisted reproduction varying sperm oocyte and uterine source and diagnosis assisted reproductive technologies uterine health more important than egg quality study shows a new antaeotricha species from florida sandhills and scrub lepidoptera depressariidae stenomatinae immaculate white new moth species preferring dry habitats is a rare case for florida a synthetic biology framework for programming eukaryotic transcription functions upgrading synthetic biology s toolkit new method could enable reprogramming of mammalian cells diminished single stimulus response in vmpfc to favorite people in children diagnosed with autism spectrum disorder scientists succeed in testing potential brain based method to diagnose autism climate change and functional traits affect population dynamics of a long lived seabird rising sea temperatures threaten survival of juvenile albatross changes in substance abuse treatment use among individuals with opioid use disorders in the united states number of addicted rises but percentage in drug treatment remains stagnant a novel risk score to predict cardiovascular disease risk in national populations globorisk a pooled analysis of prospective cohorts and health examination surveys new score predicts heart disease and stroke risk for anyone in world aged over neuronal activity enhances tau propagation and tau pathology in vivo toxic alzheimer s protein spreads through brain via extracellular space deep proteomics of the xenopus laevis egg using an mrna derived reference database national xenopus resource at the mbl innovates new way to study proteins increased gene dosage of ube a results in autism traits and decreased glutamate synaptic transmission in mice new mouse model recreates common form of autism dna profiling analysis of endometrial and ovarian cell lines reveals misidentification redundancy and contamination misidentified and contaminated cell lines lead to faulty cancer science experts say cause specific mortality for causes in china during a systematic subnational analysis for the global burden of disease study last two decades see rising life expectancy in every province of china but substantial health inequalities remain neonatal mri is associated with future cognition and academic achievement in preterm children risk of cognitive impairment in children born prematurely may be predicted using mri after birth temporary microglia depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits deep space radiation treatment reboots brain s immune system fire deficits have increased drought sensitivity in dry conifer forests fire frequency and tree ring carbon isotope evidence from central oregon tree ring analysis explains physiology behind drought intolerance identifying the target cells and mechanisms of merkel cell polyomavirus infection identifying how merkel cell polyomavirus infection can cause a lethal carcinoma measurement of external food cue responsiveness in preschool age children preliminary evidence for the use of the external food cue responsiveness scale novel scale correlates children s snacking behaviors with external food cues familial transmission of prostate breast and colorectal cancer in adoptees is related to cancer in biological but not in adoptive parents a nationwide family study genetics the dominant risk factor in common cancers dendrochilum hampelii coelogyninae epidendroideae orchidaceae traded as big pink is a new species not a hybrid evidence from nrits matk and ycf sequence data known from flower stalls as big pink orchid proved to be an undescribed wild species antibodies from a human survivor define sites of vulnerability for broad protection against ebolaviruses first human antibodies to work against all ebolaviruses potential phosphorus export in snowmelt as influenced by fertilizer placement method in the canadian prairies getting fertilizer in the right place at the right rate intranasal vaccination with influenza virus like particles protects mice and ferrets from lethal and h n influenza virus challenge new vaccination strategy may protect against both lethal and h n influenza viruses health care spending in the united states and other high income countries key drivers of high us healthcare spending identified double blind sham controlled pilot study of trigeminal nerve stimulation for adhd first double blind controlled trial of tns shows reduced symptoms in some children with adhd vocal training mitigates age related changes within the vocal mechanism in old rats singing rats show hope for older humans with age related voice problems structural insights into the human ryr n terminal region involved in cardiac arrhythmias twenty five year hunt uncovers heart defect responsible for cardiovascular diseases nuclear shape and architecture in benign fields predict biochemical recurrence in prostate cancer patients following radical prostatectomy preliminary findings changes in benign tissue next to prostate tumors may predict biomedical recurrence concussion in youth ice hockey it s time to break the cycle ban bodychecking in youth hockey to prevent concussions expert argues fidelity benchmarks for two qubit gates in silicon quantum world first researchers reveal accuracy of two qubit calculations in silicon pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type and identification of kcnrg as a bronchial autoantigen new discovery paves the way for new diagnosis of serious lung disease stand off detection of alcohol in car cabins laser device can detect alcohol in cars external device detects presence of alcohol vapors inside of a moving car glut reductions exacerbate alzheimer s disease vasculo neuronal dysfunction and degeneration low sugar uptake in brain appears to exacerbate alzheimer s disease circulating histones are major mediators of cardiac injury in patients with sepsis cause of heart damage in sepsis patients identified diversity of clinical and environmental isolates ofvibrio choleraein natural transformation and contact dependent bacterial killing indicative of type vi secretion system activity crab shell signaling helps control the many faces of cholera study shows mars growth stunted by an early giant planet instability mars growth was stunted by early giant planetary instability marked variability of monacolin levels in commercial red yeast rice products buyer beware ! active ingredient levels vary among red yeast rice supplements patient reported outcomes and survival in multiple sclerosis a year retrospective cohort study using the multiple sclerosis impact scale questionnaires can be a good predictor of survival rates in multiple sclerosis autophagy induction enhances tdp turnover and survival in neuronal als models could boosting brain cells appetites fight disease ? new research shows promise safety biodistribution and radiation dosimetry of ga ops in patients with gastroenteropancreatic neuroendocrine tumors a prospective phase i imaging study new nuclear medicine method shows promise for better detection of neuroendocrine tumors probing vasoocclusion phenomena in sickle cell anemia via mesoscopic simulations computer models shed new light on sickle cell crisis wo common single nucleotide polymorphisms in the gene encoding beta carotene u monoxygenase alter beta carotene metabolism in female volunteers uk women at risk from vitamin a deficiency the evolutionary legacy of size selective harvesting extends from genes to populations darwinian fisheries shrinking fish sizes in exploited stocks alleles underlying larval foraging behaviour influence adult dispersal in nature genetic link between feeding behavior and animal dispersal electromechanical cardioplasty using a wrapped elasto conductive epicardial mesh new electric mesh device gives the heart an electromechanical hug improving early identification and intervention for children at risk for autism spectrum disorder removing barriers to early intervention for autistic children a new model shows promise peel and stick fabricating thin film solar cell on universal substrates peel and stick solar panels decal like application process allows thin flexible solar panels to be applied to virtually any surface i would never want to have a mental health diagnosis on my record a survey of female physicians on mental health diagnosis treatment and reporting fear of stigma or sanction keeps many doctors from revealing mental health issues study finds prevalence and causes of vision loss in high income countries and in eastern and central europe rates of blindness and partial sight have plummeted in developed world memory retrieval by activating engram cells in mouse models of early alzheimer s disease flipping a light switch recovers memories lost to alzheimer s disease mice school mobility and prospective pathways to psychotic like symptoms in early adolescence a prospective birth cohort study frequent school moves can increase the risk of psychotic symptoms in early adolescence serial measures of circulating biomarkers of dairy fat and total and cause specific mortality in older adults the cardiovascular health study new research could banish guilty feeling for consuming whole dairy products active control of cell size generates spatial detail during plant organogenesis pixelated plants shed light on cell size control efforts in epilepsy prevention in the last years no change in epilepsy incidence in younger patients increase among elderly increased mucosal neutrophil survival is associated with altered microbiota in hiv infection longer neutrophil lifespan may contribute to hiv associated intestinal inflammation early il production is essential for syngeneic graft acceptance il from donor skin cells helps the body incorporate skin grafts notch signaling activation in pediatric low grade astrocytoma cell signaling pathway goes awry in common pediatric brain tumor diluted honey inhibits biofilm formation potential application in urinary catheter management ? manuka honey curbs activity growth of bacteria even at low dilutions an interferon driven oxysterol based defense against tumor derived extracellular vesicles hindering melanoma metastasis with an fda approved drug restaurant s decision to purchase local foods influence of value chain activities experience helps restaurant managers stick with local foods expression of endogenous retroviruses reflects increased usage of atypical enhancers in t cells multiple sclerosis discovery of a mechanism responsible for chronic inflammation risk of cancer in children and young adults conceived by assisted reproductive technology no overall increased risk of cancer in children born after fertility treatment microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase study identifies possible role for carbon monoxide in treating hemorrhagic stroke frogs use a viscoelastic tongue and non newtonian saliva to catch prey reversible saliva allows frogs to hang onto next meal who is saying what ? brain based decoding of human voice and speech neuroimaging of brain shows who spoke to a person and what was said targeted gene inactivation in zebrafish using engineered zinc finger nucleases new technique allows targeted inactivation of genes in research model test of the invasive pathogen hypothesis of bumble bee decline in north america commercial bumble bee industry amplified a fungal pathogen of bees study suggest rare functional variant in tm d is associated with late onset alzheimer s disease newly identified rare alzheimer s disease gene mutation more common in icelandic people sleep disturbances in prepubertal children with attention deficit hyperactivity disorder a home polysomnography study underlying sleep problem linked to attention deficit hyperactivity disorder in children mbtps mutations cause defective regulated intramembrane proteolysis in x linked osteogenesis imperfecta new type of rare brittle bone disease discovered planning facility location under generally correlated facility disruptions use of supporting stations and quasi probabilities new way of designing systems against correlated disruptions uses negative probability characterization of lethal zika virus infection in ag mice scientists describe new research model to enhance zika virus research the origins of multifractality in financial time series and the effect of extreme events early detection of extreme financial events market crashes are anomalous features in financial data fractal landscape identification of pkd l gene variants in children with the biliary atresia splenic malformation syndrome first genetic clue for elusive pediatric liver disease cochlear implant users move in time to the beat of drum music cochlear implant users can hear feel the beat in music survival without cardiac transplantation among children with dilated cardiomyopathy children with heart failure from dilated cardiomyopathy are seeing a dramatic improvement in outcomes in recent years zika virus productively infects primary human placenta specific macrophages study identifies how zika virus infects the placenta interleukin receptor activation by systemic lipopolysaccharide induces behavioral despair linked to mapk regulation of cns serotonin transporters link between depression and inflammatory response found in mice new treatments for mood disorders ? a comparison of language use in pro and anti vaccination comments in response to a high profile facebook post high profile facebook post provides insights into pro and anti vaccination beliefs staphylococcus aureus protein a binds to osteoblasts and triggers signals that weaken bone in osteomyelitis novel drug target for treatment of infection in bone pupillary light reflex to light inside the natural blind spot pupillary reflex enhanced by light inside blind spot host dna released in response to aluminum adjuvant enhances mhc class ii mediated antigen presentation and prolongs cd t cell interactions with dendritic cells vaccine adjuvant uses host dna to boost pathogen recognition correlated increase of high ocean waves and winds in the ice free waters of the arctic ocean researchers investigate the correlation between wind and wave height in the arctic ocean complex craniofacial changes in blind cave dwelling fish are mediated by genetically symmetric and asymmetric loci cave dwelling fish examination finds possible genetic link to human disorders prevalence of inappropriate antibiotic prescriptions among us ambulatory care visits high rate of inappropriate antibiotic prescriptions in us research finds statins for primary prevention of cardiovascular events and mortality in old and very old adults with and without type diabetes retrospective cohort study widespread use of statins in healthy older people to prevent heart disease not recommended in new study the contribution of badgers to confirmed tuberculosis in cattle in high incidence areas in england badgers ultimately responsible for around half of tb in cattle global assessment of the status of coral reef herbivorous fishes evidence for fishing effects first global snapshot of key coral reef fishes fishing has reduced vital seaweed eaters by more than percent high fat diet enhances stemness and tumorigenicity of intestinal progenitors high fat diet linked to intestinal stem cell changes increased risk for cancer orco mutagenesis causes loss of antennal lobe glomeruli and impaired social behavior in ants first mutant ants shed light on evolution of social behavior price inferences for sacred versus secular goods changing the price of medicine influences perceived health risk does changing the price of medicine influence consumers perceived health risk ? overexpression of cx in cells of the myocardial scar correction of post infarct arrhythmias through heterotypic cell cell coupling cardiac arrhythmias expression of connexin in infarct scar cuts cardiac arrhythmias after heart attack exposure to domestic violence and abuse evidence of distinct physical and psychological dimensions exposure to psychological domestic abuse most damaging to children s wellbeing the glia derived alarmin il orchestrates the immune response and promotes recovery following cns injury trigger for protective immune response to spinal cord injury found endocardially derived macrophages are essential for valvular remodeling scientists discover new type of immune cells that are essential for forming heart valves ice volume forced erosion of the chinese loess plateau global quaternary stratotype site desertification and monsoon climate change linked to shifts in ice volume and sea level identification of the mechanisms causing reversion to virulence in an attenuated sars cov for the design of a genetically stable vaccine towards a safe and efficient sars coronavirus vaccine mechanism and prevention of genetic instability of a live attenuated virus robot assisted surgery for upper aerodigestive tract neoplasms robot assisted surgery appears useful for removal of some head and neck tumors field versus farm in warangal bt cotton higher yields and larger questions new findings in india s bt cotton controversy good for the field bad for the farm ? behavioural tactic predicts preoptic hypothalamic gene expression more strongly than developmental morph in fish with alternative reproductive tactics fish study ids genes that regulate social behaviors how pupils on the autism spectrum make sense of themselves in the context of their experiences in a mainstream school setting a qualitative metasynthesis school exacerbates feelings of being different in pupils with autism spectrum conditions revisiting the past to foretell the future summer temperature and habitat area predict pika extirpations in california shrinking range of pikas in california mountains linked to climate change ultraviolet a does not induce melanomas in a xiphophorus hybrid fish model melanoma not caused by early ultraviolet uva light exposure new fish experiments show engineering the fragment crystallizable fc region of human igg multimers and monomers to fine tune interactions with sialic acid dependent receptors new ways to create deliver medications for immune medicated neuropathies fast current driven domain walls and small skyrmions in a compensated ferrimagnet extremely small magnetic nanostructures with invisibility cloak imaged epigenetic variation in the mu opioid receptor gene in infants with neonatal abstinence syndrome in utero methadone subutex exposure could alter gene expression cause severe neonatal abstinence syndrome immune signatures following single dose trastuzumab predict pathologic response to preoperative trastuzumab and chemotherapy in her positive early breast cancer single dose of trastuzumab kick starts immune response in certain breast cancers fusion of deep learning models of mri scans mini mental state examination and logical memory test enhances diagnosis of mild cognitive impairment researchers develop combined data model to better evaluate for mild cognitive impairment external gills and adaptive embryo behavior facilitate synchronous development and hatching plasticity under respiratory constraint red eyed treefrog embryos actively avoid asphyxiation inside their eggs prevalence and compensation of academic leaders professors and trustees on publicly traded us healthcare company boards of directors cross sectional study many nonprofit academic leaders and professors serve on for profit health care company boards urinary metabolomics reveals the therapeutic effect of huangqi injections in cisplatin induced nephrotoxic rats high fat high carb diet a cause of osteoarthritis hypoxic volume is more responsive than hypoxic area to nutrient load reductions in the northern gulf of mexico and it matters to fish and fisheries dead zone volume more important than area to fish fisheries transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity dependent genes in autism brain inflammation a hallmark of autism large scale analysis shows mass immigration of juvenile fishes into a small once dried tributary demonstrates the importance of remnant tributaries as wintering habitats once dried tiny tributary serves as shelter for wintering fish changes in taste function related to obesity and chronic otitis media with effusion changes in taste function related to obesity and chronic ear inflammation phylosymbiosis relationships and functional effects of microbial communities across host evolutionary history each animal species hosts a unique microbial community and benefits from it association of gastric acid suppression with recurrent clostridium difficile infection gastric medications increase risk for recurrence of clostridium difficile infection wave particle energy exchange directly observed in a kinetic alfv n branch wave basic plasma wave physics reshaped by nasa observations dysfunction and dysconnection in cortical striatal networks during sustained attention genetic risk for schizophrenia or bipolar disorder and its impact on brain network function children at risk for mental disorders experience communication breakdown in brain networks supporting attention impairing oral tolerance promotes allergy and anaphylaxis a new murine food allergy model of mice and peanuts a new mouse model for peanut allergy associations of variability in blood pressure glucose and cholesterol concentrations and body mass index with mortality and cardiovascular outcomes in the general population yo yoing weight blood pressure cholesterol and blood sugar readings may raise heart attack and stroke risk inferred paternity and male reproductive success in a killer whale orcinus orca population paternity testing helps fill in family tree for puget sound s killer whales inbreeding could reduce whales genetic diversity use of electronic cigarettes among u.s. adults with medical comorbidities e cigarettes popular among smokers with existing illnesses newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the liverpool epidemic strain of pseudomonas aeruginosa viral dna in bacterial genome could hold key to novel cystic fibrosis treatments long term results of stenting versus endarterectomy for carotid artery stenosis stenting and surgery effectively lower long term risk of stroke aging neural progenitors lose competence to respond to mitogenic notch signaling molecular shift stops stem cells in drosophila from making tumors online opportunities a quantitative content analysis benchmark study of online retail plant sales selling plants on amazon a forest of untapped opportunity metabolic differentiation of early lyme disease from southern tick associated rash illness stari new test differentiates between lyme disease similar illness soccer training improves cardiac function in men with type diabetes soccer training improves heart health of men with type diabetes an integrated framework to identify wildlife populations under threat from climate change climate change could put rare bat species at greater risk lactic acid bacteria isolated from european badgers meles meles reduce the viability and survival of bacillus calmette guerin bcg vaccine and influence the immune response to bcg in a human macrophage model european badgers gut bacteria may be a powerful ally in the fight against tuberculosis mutual regulation of tumour vessel normalization and immunostimulatory reprogramming blood vessels and the immune system talk to each other a comprehensive genomes based genome wide association meta analysis of coronary artery disease important scientific debate connected to heart disease now answered ecological contingency in the effects of climatic warming on forest herb communities low elevations hold climate surprises for mountain plants exceptional fossil preservation demonstrates a new mode of axial skeleton elongation in early ray finned fishes exceptional fossil fish reveals new evolutionary mechanism for body elongation the molecular evolution of acquired resistance to targeted egfr blockade in colorectal cancers transforming cancer into a manageable illness with multi drug approach histopathologic observations after intra arterial chemotherapy for retinoblastoma study evaluates eye findings after use of intra arterial chemotherapy for retinoblastoma predictors of public climate change awareness and risk perception around the world predictors of climate change awareness risk perception vary around the globe control of luminescence from pigmy shark squaliolus aliae photophores smalleye pigmy sharks bellies shine they glow for camouflage complementary and alternative medicine a survey of its use in pediatric cardiology discussing alternative medicine choices for better health outcomes australian climate extremes at. c and c of global warming heat on for australia s great barrier reef when global temperatures hit. c connecticut s money follows the person yields positive results for transitioning people out of institutions thousands of older adults persons with disabilities transitioning home randomized blinded sham controlled trial of acupuncture for the management of aromatase inhibitor associated joint symptoms in women with early stage breast cancer acupuncture may relieve joint pain caused by some breast cancer treatments learning problems in children of refugee background a systematic review refugee children s academic outcomes similar to non refugee peers despite learning challenges nutrition management of gastrointestinal symptoms in children with autism spectrum disorder guideline from an expert panel expert panel sets nutrition guidelines to manage gi symptoms in autism screening for syphilis infection in nonpregnant adults and adolescents screening for syphilis recommended for persons at increased risk of infection the swine plasma metabolome chronicles many days biological timing and functions linked to growth study links life s milestones to a non circadian biological rhythm in teeth cannabinoid receptor mediated attenuation of cxcr tropic hiv infection in primary cd t cells marijuana like chemicals inhibit human immunodeficiency virus hiv in late state aids peptide inhibitors targeting the neisseria gonorrhoeae pivotal anaerobic respiration factor ania new gonorrhea treatment targets enzyme needed for respiration the effects of climate extremes on global agricultural yields climate extremes impact on global crop yield variations changes in conceptions in women younger than years and the circumstances of young mothers in england in an observational study teenage pregnancies hit record low reflecting efforts of england s strategy to reduce under conceptions antenatal corticosteroids for maturity of term or near term fetuses systematic review and meta analysis of randomized controlled trials reducing risk of lung distress in preterm babies small molecule inhibition of brdt for male contraception finally the promise of male birth control in a pill compound makes mice reversibly infertile comparative effectiveness of the nicotine lozenge and tobacco free snuff for smokeless tobacco reduction nicotine lozenges tobacco free snuff help smokeless tobacco users quit clinically assessed posttraumatic stress in patients with breast cancer during the first year after diagnosis in the prospective longitudinal controlled cognicares study breast cancer the mental trauma of severe disease a new species of micro mangrove crab of the genus haberma ng schubart crustacea brachyura sesarmidae from hong kong new species of terrestrial crab found climbing on trees in hong kong axon death pathways converge on axundead to promote functional and structural axon disassembly study identifies new target to preserve nerve function excess tgf mediates muscle weakness associated with bone metastases in mice researchers find pathway to cancer associated muscle weakness targeting of alpha hemolysin by active or passive immunization decreases severity of usa skin infection in a mouse model treatment for s. aureus skin infection works in mouse model magnetic resonance spectroscopy of current hand amputees reveals evidence for neuronal level changes in former sensorimotor cortex cortical nerve function in former amputees remains poor decades after reconstructive surgery prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury a prospective cohort study golden hour study details earliest changes to the immune system after trauma single step fermentative production of the cholesterol lowering drug pravastatin via reprogramming ofpenicillium chrysogenum synthetic biology breakthrough leads to cheaper statin production severe bilateral cerebellar edema from ingestion of ketamine case report clinical appearance and unusual imaging findings of pediatric ketamine overdose relationship between sperm whale physeter macrocephalus click structure and size derived from videocamera images of a depredating whale sperm whale prey acquisition thieving whale caught on video gives rare clues about hunting strategy sound production water driven micromotors for rapid photocatalytic degradation of biological and chemical warfare agents microrockets fueled by water neutralize chemical and biological warfare agents genetic scores to stratify risk of developing multiple islet autoantibodies and type diabetes a prospective study in children genes can help predict children s risk of type diabetes mucolipin co deficiency causes accelerated endolysosomal vacuolation of enterocytes and failure to thrive from birth to weaning infant failure to thrive linked to lysosome dysfunction prospective validation of a hour algorithm to rule out and rule in acute myocardial infarction using a high sensitivity cardiac troponin t assay new strategy can help determine heart attack in patients within one hour beta diversity on deep sea wood falls reflects gradients in energy availability sunken logs create new worlds for seafloor animals anticoagulant activity of enoxaparin and unfractionated heparin for venous thromboembolism prophylaxis in obese patients undergoing sleeve gastrectomy lack of standard dosage for blood thinners can lead to bleeding during bariatric surgery secretion mediated stat activation promotes self renewal of glioma stem like cells during hypoxia scientists target glioma cancer stem cells which could improve patient survival human body epigenome maps reveal noncanonical dna methylation variation scientists reveal epigenome maps of the human body s major organs rapid digital game creation for broadening participation in computing and fostering crucial thinking skills learning the art of creating computer games can boot student skills hps thrive randomized placebo controlled trial in high risk patients of er niacin laropiprant trial design pre specified muscle and liver outcomes and reasons for stopping study treatment muscle skin and gastrointestinal problems cause a quarter of patients with heart disease and strokes to stop treatment in hps thrive trial lgi truncation causes a remitting focal epilepsy in dogs gene discovery in truffle dogs sheds new light on mechanisms of childhood epilepsy combinatorial patterns of histone acetylations and methylations in the human genome scientists discover key patterns in the packaging of genes treatment response prediction and individualized identification of first episode drug na ve schizophrenia using brain functional connectivity machine learning helps to predict the treatment outcomes of schizophrenia association of depression and anxiety disorders with autoimmune thyroiditis new hope for patients with depression and anxiety a quantitative link between face discrimination deficits and neuronal selectivity for faces in autism difficulty in recognizing faces in autism linked to performance in a group of neurons gaia dr reveals a star formation burst in the disc gyr ago star formation burst in the milky way billion years ago emas position statement managing menopausal women with a personal or family history of vte position statement about the post reproductive health of women published association of alcohol consumption after development of heart failure with survival among older adults in the cardiovascular health study moderate drinking not harmful for older patients with heart failure study suggests depression inflammation and pain in patients with rheumatoid arthritis depression and inflammation linked to pain in rheumatoid arthritis patients persistence of intense climate driven runoff late in mars history rivers raged on mars late into its history integrated microrna and mrna signatures associated with survival in triple negative breast cancer triple negative breast cancer subtypes identified using microrna altered white matter integrity in adolescent binge drinkers adolescent binge drinking may compromise the brain s white matter necessary for information relay generation of random numbers by measuring phase fluctuations from a laser diode with a silicon on insulator chip generation of random numbers by measuring phase fluctuations from a laser diode with a silicon on in using us data to estimate the incidence of serious physical abuse in children children hospitalized at alarming rate due to abuse u.s. study finds complete arsenic based respiratory cycle in the marine microbial communities of pelagic oxygen deficient zones arsenic breathing life discovered in the tropical pacific ocean mitigating amphibian disease strategies to maintain wild populations and control chytridiomycosis fighting massive declines in frog populations with bacteria and fungicides the photospheric origin of the yonetoku relation in gamma ray bursts origin of photons in mysterious gamma ray bursts tai chi is effective in treating knee osteoarthritis a randomized controlled trial tai chi exercise reduces knee osteoarthritis pain in the elderly research shows sturge weber syndrome and port wine stains caused by somatic mutation ingnaq game changing discovery of gene mutation that causes sturge weber syndrome port wine stain birthmarks offers new hope spatial immobilization of bone morphogenetic protein in a collagen plga hybrid scaffold for enhanced osteoinductivity bone tissue engineering attaching proteins for better regeneration the contribution of tobacco use to high health care utilization and medical costs in peripheral artery disease smoking increases hospitalizations costs of peripheral artery disease eosinophils increase airway sensory nerve density in mice and in human asthma excessive airway nerves tied to more severe asthma symptoms study finds compact design of a hydraulic driving robot for intraoperative mri guided bilateral stereotactic neurosurgery world s first intra operative mri guided robot for bilateral stereotactic neurosurgery macrophage migration inhibitory factor is subjected to glucose modification and oxidation in alzheimer s disease sugar s tipping point link to alzheimer s disease revealed association of impaired functional status at hospital discharge and subsequent rehospitalization standard test that measures everyday task performance is a good predictor of hospital readmission passive acoustic monitoring of the decline of mexico s critically endangered vaquita fishery bycatch rapidly driving mexico s vaquita to extinction arabidopsis plants perform arithmetic division to prevent starvation at night biological arithmetic plants do sums to get through the night pulmonary symptoms measured by the national institutes of health lung score predict overall survival nonrelapse mortality and patient reported outcomes in chronic graft versus host disease early detection helps manage chronic graft vs host disease complication suppression of amyloid a antibody immunoreactivity by vitamin c possible role of heparan sulfate oligosaccharides derived from glypican by ascorbate induced nitric oxide no catalyzed degradation treatment with vitamin c dissolves toxic protein aggregates in alzheimer s disease stochastic density effects on adult fish survival and implications for population fluctuations a fine kettle of fish marine fish influenced by food supply upon which they depend and on competition for those resources specialist palliative care support is associated with improved pain relief at home during the last months of life in patients with advanced disease analysis of year data from the national survey of bereaved people voices unequal pain relief at home for dying patients highly conserved molecular pathways including wnt signaling promote functional recovery from spinal cord injury in lampreys genes that aid spinal cord healing in lamprey also present in humans researchers discover corticosteroid loaded biodegradable nanoparticles for prevention of corneal allograft rejection in rats tiny nanoparticles could make big impact for patients in need of cornea transplant ecological networks are more sensitive to plant than to animal extinction under climate change domino effect the loss of plant species triggers the extinction of animals competitors as accomplices seaweed competitors hide corals from predatory sea stars foes can become friends on the coral reef how seaweed becomes coral s friend when sea stars invade monitoring the response of bone metastases to treatment with magnetic resonance imaging and nuclear medicine techniques a review and position statement by the european organisation for research and treatment of cancer imaging group monitoring response of bone metastases to treatment using mri pet neural underpinnings of working memory in adult survivors of childhood brain tumors childhood brain tumors affect working memory of adult survivors study finds frost fairs sunspots and the little ice age paintings sunspots and frost fairs rethinking the little ice age enamel hypomineralization and structural defects in amelotin deficient mice amelotin molecule plays critical role in tooth enamel maturation reassessment of pre industrial fire emissions strongly affects anthropogenic aerosol forcing cooling effect of preindustrial fires on climate underestimated effects of occupational role conflict and emotional demands on subsequent psychological distress role conflict and emotional demands are most important risk factors for distress in workers long term treatment with proton pump inhibitor is associated with undesired weight gain long term treatment with proton pump inhibitor can increase weight beta cell dysfunction due to increased er stress in a stem cell model of wolfram syndrome human stem cells used to reveal mechanisms of beta cell failure in diabetes impact of age at diagnosis and duration of type diabetes on mortality in australia younger age at diabetes diagnosis is linked to higher risk of death from heart disease and stroke yet lower risk of cancer death modeling the mutational and phenotypic landscapes of pelizaeus merzbacher disease with human ipsc derived oligodendrocytes stem cells help explain varied genetics behind rare neurologic disease toll like receptor is required for effective adaptive immune responses that prevent persistent virus infection lack of single protein results in persistent viral infection exposure to fine particulate air pollution is associated with endothelial injury and systemic inflammation air pollution linked to blood vessel damage in healthy young adults live transference of surgical subspecialty skills using telerobotic proctoring to remote general surgeons telementoring may address need for surgical subspecialty expertise in remote locations association of socioeconomic status in childhood with left ventricular structure and diastolic function in adulthood the cardiovascular risk in young finns study is there an association between socioeconomic status in childhood and the heart ? genetic association and expression studies indicate a role of toll like receptor in pulmonary tuberculosis gene with probable role in human susceptibility to pulmonary tuberculosis identified imaging of language related brain regions in detoxified alcoholics the brain maintains language skills in spite of alcohol damage by drawing from other regions prognostic indicators of low back pain in primary care five year prospective study severity of acute low back pain predicts development of chronic pain shifting gears diversification intensification and effort increases in small scale fisheries coral reefs suffering in philippines despite outlawing damaging fishing practices a comprehensive three dimensional radiative magnetohydrodynamic simulation of a solar flare from emergence to eruption comprehensive model captures life of a solar flare tabletop molecular communication text messages through chemical signals world s first text message using vodka messages sent via molecules can aid communication underground underwater or inside the body prevalence of antibody to toxoplasma gondii in terrestrial wildlife in a natural area cats pass disease to wildlife even in remote areas tnnt nemaline myopathy natural history and therapeutic frontier amish nemaline myopathy natural history study finds promise for gene therapy treatment association of a germline copy number polymorphism of apobec a and apobec b with burden of putative apobec dependent mutations in breast cancer virus fighting genes linked to mutations in cancer genetic evidence supports role of gene family in cancer development the wheat microbiome under four management strategies and potential for endophytes in disease protection novel wheat microbiome analysis conducted under four management strategies business culture and dishonesty in the banking industry business culture in banking industry favors dishonest behavior phenocopies in melanoma prone families with germ line cdkn a mutations family members without inherited mutation have increased risk of melanoma uv irradiation of polycyclic aromatic hydrocarbons in ices production of alcohols quinones and ethers nasa identifies carbon rich molecules in meteors as the origin of life multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth manduca sexta a very hungry caterpillar researchers sequence genome of gluttonous tobacco hornworm craf gene fusions in pediatric low grade gliomas define a distinct drug response based on dimerization profiles biology of childhood brain tumor subtypes offers clues to precision treatments does early stress prepare individuals for a stressful future ? stress during adolescence improves foraging under threat stress in adolescence prepares rats for future challenges association of a full day vs part day preschool intervention with school readiness attendance and parent involvement full day preschool linked with increased school readiness compared with part day associations between physical activity and mental health among bariatric surgical candidates even limited physical activity is linked to lower rates of depression in bariatric surgery patients direct measurements of two way wave particle energy transfer in a collisionless space plasma wave particle interactions allow collision free energy transfer in space plasma nat promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells induced pluripotent stem cells don t increase genetic mutations evo devo models of tooth development and the origin of hominoid molar diversity the secret life of teeth evo devo models of tooth development emotional behavioral and developmental features indicative of neglect or emotional abuse in preschool childrena systematic reviewfeatures indicative of emotional abuse intervention to reduce lifelong effects associated with childhood neglect and emotional abuse comparing reconstructed past variations and future projections of the baltic sea ecosystem first results from multi model ensemble simulations climate change threatens marine environment in the baltic sea cyanobacterial blooms in the central basin of lake erie potentials for cyanotoxins and environmental drivers algal blooms in lake erie s central basin could produce neurotoxins health system costs for individual and comorbid noncommunicable diseases an analysis of publicly funded health events from new zealand having more than one chronic disease amplifies costs of diseases domain focused crispr screen identifies hri as a fetal hemoglobin regulator in human erythroid cells enzyme identified as possible novel drug target for sickle cell disease thalassemia fear and panic in humans with bilateral amygdala damage human brain is divided on fear and panic different areas of brain responsible for external internal threats reduced selection and accumulation of deleterious mutations in genes exclusively expressed in men mutations from venus mutations from mars why genetic fertility problems can persist in a population stat is constitutively activated in chronic active epstein barr virus infection and can be a therapeutic target stat can be a therapeutic target for chronic active ebv infection a fatal disorder a systematic review of behavioural techniques used in nutrition and weight loss interventions among adults with mobility impairing neurological and musculoskeletal conditions more weight loss strategies needed for people with neurological disabilities comprehensive stroke centers may be associated with improved survival in hemorrhagic stroke comprehensive stroke centers may improve bleeding stroke survival changes in segmentation and setation along the anterior posterior axis of the homonomous trunk limbs of a remipede crustacea arthropoda mathematical analysis conducted of a rare cavernicolous crustacean tendon stem progenitor cells regulate inflammation in tendon healing via jnk and stat signaling stem cells may significantly improve tendon healing by regulating inflammation digital synchroballistic schlieren camera for high speed photography of bullets and rocket sleds digital streak camera captures full color photographs of high speed objects random codon re encoding induces stable reduction of replicative fitness of chikungunya virus in primate and mosquito cells promising new method for next generation live attenuated viral vaccines against chikungunya virus delayed initiation of adjuvant chemotherapy among patients with breast cancer survival and time to surgery chemotherapy for patients with breast cancer brain derived neurotrophic factor val met human polymorphism impairs the beneficial exercise induced neurobiological changes in mice common genetic variant regulates the mental health benefits of exercise addressing the lack of competition in generic drugs to improve healthcare quality and safety potential solutions to drug shortages and the lack of competition in generic medicines effects of in utero exposure to arsenic during the second half of gestation on reproductive end points and metabolic parameters in female cd mice low level arsenic exposure before birth associated with early puberty and obesity oxytocin enables maternal behaviour by balancing cortical inhibition how oxytocin makes a mom hormone teaches maternal brain to respond to offspring s needs single cell transcriptomic analysis of primary and metastatic tumor ecosystems in head and neck cancer invasive cells in head and neck tumors predict cancer spread optimizing cancer treatment using game theory a review viewing cancer treatment as a game to find strategies that improve patient outcomes gait in mild alzheimer s disease feasibility of multi center measurement in the clinic and home with body worn sensors a pilot study gait assessed with body worn sensors may help detect onset of alzheimer s disease low coverage single cell mrna sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex single cell analysis holds promise for stem cell and cancer research non targeted effects models predict significantly higher mars mission cancer risk than targeted effects models collateral damage from cosmic rays increases cancer risks for mars astronauts non invasive electrocardiogram detection of in vivo zebrafish embryos using electric potential sensors highly sensitive sensors successfully map electrical patterns of embryonic heart a drought resistance promoting microbiome is selected by root system under desert farming desert farming forms bacterial communities that promote drought resistance laryngoscopy during swimming a novel diagnostic technique to characterize swimming induced laryngeal obstruction novel technique helps diagnose swimming induced respiratory condition beneficial effects of a higher protein breakfast on the appetitive hormonal and neural signals controlling energy intake regulation in overweight obese breakfast skipping late adolescent girls protein rich breakfasts prevent unhealthy snacking in the evening study finds new training systems for high density planting of sweet cherry new training ultra high density planting systems recommended for sweet cherry a radio counterpart to a neutron star merger radio eyes unlocking secrets of neutron star collision impact of the hiv epidemic on the incidence rates of anal cancer in the united states hiv helps explain rise of anal cancer in us males number of oral contraceptive pill packages dispensed and subsequent unintended pregnancies increased contraceptive supply linked to fewer unintended pregnancies preparing national health systems to cope with the impending tsunami of ageing and its associated complexities towards more sustainable health care healthcare systems must adapt to cope with escalating impact of ageing populations outdoor light at night and breast cancer incidence in the nurses health study ii outdoor light at night linked with increased breast cancer risk in women airplane pilot flight performance on maneuvers in a flight simulator under varying carbon dioxide concentrations carbon dioxide levels on flight deck affect airline pilot performance genetics and the clinical response to warfarin and edoxaban findings from the randomised double blind engage af timi trial conclusive link between genetics clinical response to warfarin uncovered high performance perovskite cu in ga se monolithic tandem solar cells dual layer solar cell sets record for efficiently generating power cftr delivery to of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium common cold virus efficiently delivers corrected gene to cystic fibrosis cells long term nitrogen addition causes the evolution of less cooperative mutualists long term nitrogen fertilizer use disrupts plant microbe mutualisms attenuation of the effect of the fto rs polymorphism on total and central body fat by physical activity in adolescents the helena study exercise associated with reduced effects of obesity gene in teens qualitative analysis of serious case reviews into unexpected infant deaths first ever study of serious case reviews of sudden unexpected infant deaths conducted aromatase inhibition remodels the clonal architecture of estrogen receptor positive breast cancers research reveals patient can have more than one breast cancer points at treatments swept source optical coherence tomography and tunable lens technology for comprehensive imaging and biometry of the whole eye new instrument lets doctors view the entire eye with unprecedented level of detail official catch data underrepresent shark and ray taxa caught in mediterranean and black sea fisheries official stats mask shark and ray species caught in the mediterranean and black seas parent report of food allergy management by pediatricians and allergists parents in dark about using epinephrine for kids food allergies increased activity of tnap compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease acdc researchers identify biochemical mechanism behind a rare painful genetic disease reference component analysis of single cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors single cell analysis reveals subtypes of colorectal tumors persistence of ebola virus in ocular fluid during convalescence ebola virus in patient s eye fluid weeks after it was undetectable in blood suicidality self harm and body dissatisfaction in transgender adolescents and emerging adults with gender dysphoria high rates of suicide and self harm among transgender youth genetic and morphological variation between populations of the pascagoula map turtle graptemys gibbonsi in the pearl and pascagoula rivers with description of a new species scientists bring new species of turtle out of its shell chlorine isotopes as tracers of solute origin and age of groundwaters from the eastern desert of egypt researchers examine the age of groundwater in egyptian aquifers chitosan poly vinyl alcohol hydrogel combined with ad htgf transfected mesenchymal stem cells to repair rabbit articular cartilage defects repairing articular cartilage defects with an injectable gel engineered with gene modified bmscs safety and efficacy of plasmid dna expressing two isoforms of hepatocyte growth factor in patients with critical limb ischemia promising results from clinical study using plasmid dna gene therapy efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder intravenously administered ketamine shown to reduce symptoms of chronic post traumatic stress disorder alternative student based revenue streams for higher education institutions a difference in difference analysis using guaranteed tuition policies guaranteed tuition laws inflating college costs study finds calibration of multiple in silico tools for predicting pathogenicity of mismatch repair gene missense substitutions genetic test results for lynch syndrome improved with new computer program early human symbolic behavior in the late pleistocene of wallacea prehistoric art and ornaments from indonesian ice age growth hormone improves cognitive function after experimental stroke growth hormone may provide new hope for stroke survivors pkc rdx driven phosphorylation of pdk a novel mechanism promoting cancer cell survival and permissiveness for parvovirus induced lysis deadly to cancer cells only molecular cause for selective effectiveness of parvovirus therapy discovered skeleton of an unusual cat sized marsupial relative metatheria marsupialiformes from the middle eocene lutetian million years ago of turkey euro devil fossil of carnivorous marsupial relative discovered in e europe distinctive patterns of dna methylation associated with parkinson disease identification of concordant epigenetic changes in brain and peripheral blood leukocytes epigenetic changes observed in blood may point to early stages in parkinson disease type i interferons inhibit interleukin signaling and favor type diabetes development in nonobese diabetic mice failing immune system brakes help explain type diabetes in mice temperature response of soil respiration largely unaltered with experimental warming study finds limited sign of soil adaptation to climate warming training change agents in cta to bring health care transformation to scale the case of primary care practice facilitators helping doctors transform their practices into patient centered models of health care slow adaptation in the face of rapid warming leads to collapse of the gulf of maine cod fishery warming waters a major factor in the collapse of new england cod competition between jagged notch and endothelin signaling selectively restricts cartilage formation in the zebrafish upper face how skeletal stem cells form the blueprint of the face prelegalisation patterns and trends of cannabis use among canadian youth results from the compass prospective cohort study surge in cannabis use among youth preceded legalization in canada ipsc derived dopamine neurons reveal differences between monozygotic twins discordant for parkinson s disease scientists create parkinson s disease in a dish extensive sampling of basidiomycete genomes demonstrates inadequacy of the white rot brown rot paradigm for wood decay fungi treading into gray area along spectrum of wood decay fungi the dark side of internet use two longitudinal studies of excessive internet use depressive symptoms school burnout and engagement among finnish early and late adolescents internet addiction school burnout feed into each other ageing gracefully physiology but not behaviour declines with age in a diving seabird aging gracefully diving seabirds shed light on declines with age e cigarette vapor induces an apoptotic response in human gingival epithelial cells through the caspase pathway smoking electronic cigarettes kills large number of mouth cells highly sensitive detection of dengue virus nucleic acid in samples from clinically ill patients new highly sensitive method may offer early detection of dengue virus variation in the net benefit of aggressive cardiovascular risk factor control across the us population of patients with diabetes mellitus aggressive control of cardiac risk factors might not benefit all patients with diabetes preinjury psychiatric status injury severity and postdeployment posttraumatic stress disorder post deployment ptsd symptoms more common in military personnel with prior mental health disorders early life home environment and risk of asthma among inner city children exposure to pet and pest allergens during infancy linked to reduced asthma risk microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells thymus cells transform into skin cells in swiss laboratory moisture variability in the southwestern united states linked to abrupt glacial climate change cave reveals southwest s abrupt climate swings during ice age systematic assessment of the leporinus desmotes species complex with a description of two new species scientists name new species of fish from the orinoco region after singer enya evolution of bower building in lake malawi cichlid fish phylogeny morphology and behavior male fish dig pits and build sand castles at the bottom of lake malawi to attract females molecular modeling organ culture and reverse genetics for a newly identified human rhinovirus c insights gained from growing cold causing virus on sinus tissue lung function and incidence of chronic obstructive pulmonary disease after improved cooking fuels and kitchen ventilation a year prospective cohort study clean cooking fuel and improved kitchen ventilation linked to less lung disease bivalirudin vs heparin with or without tirofiban during primary percutaneous coronary intervention in acute myocardial infarction percutaneous coronary intervention bivalirudin superior to both heparin monotherapy and heparin plus tirofiban in acute myocardial infarction mediterranean diets and metabolic syndrome status in the predimed randomized trial mediterranean diet olive oil and nuts can help reverse metabolic syndrome a cocktail inspired male birth control strategy with physical chemical dual contraceptive effects and remote self cleared properties layered cocktails inspire new form of male birth control perioperative surgical care bundle reduces pancreaticoduodenectomy wound infections whipple procedure wound infections cut in half with new measures source identification in two criminal cases using phylogenetic analysis of hiv dna sequences molecular evolution proves source of hiv infection in criminal cases extracorporeal arteriovenous ultrasound measurement of cardiac output in small children ultrasound provides precise minimally invasive way to measure heart function in children virologic failure following persistent low level viremia in a cohort of hiv positive patients results from years of observation risk of hiv treatment failure present even in those with low viral load paradoxical activation and raf inhibitor resistance of braf protein kinase fusions characterizing pediatric astrocytomas details of gene pathways suggest fine tuning drugs for child brain tumors anxiogenic effects of developmental bisphenol a exposure are associated with gene expression changes in the juvenile rat amygdala and mitigated by soy exposure to bisphenol a bpa early in life results in high levels of anxiety soy mitigates effects study shows high fabrication yield organic tandem photovoltaics combining vacuum and solution processed subcells with efficiency organic solar cells reach record efficiency benchmark for commercialization association of pyrethroid pesticide exposure with attention deficit hyperactivity disorder in a nationally representative sample of u.s. children study links exposure to common pesticide with adhd in boys criminal justice and school sanctions against nonheterosexual youth a national longitudinal study lesbian gay and bisexual teens singled out for punishment study finds maple syrup decreases tdp proteotoxicity in a c. elegans model of als maple syrup protects neurons and nurtures young minds individual behaviors dominate the dynamics of an urban mountain lion population isolated by roads freeways as fences trapping the mountain lions of los angeles trends in smoking among adults with mental illness and association between mental health treatment and smoking cessation adults with mental illness have lower rate of decline in smoking differential regenerative capacity of neonatal mouse hearts after cryoinjury mammalian heart regenerative capacity depends on severity of injury outbreak of sudden death with acute encephalitis syndrome among children associated with exposure to lychee orchards in northern bangladesh study links sudden deaths in bangladeshi children to chemicals sprayed on fruit trees safety and tolerability of guadecitabine sgi in patients with myelodysplastic syndrome and acute myeloid leukaemia a multicentre randomised dose escalation phase study researchers testing drug for cancer bone marrow disorders changes in coral reef communities across a natural gradient in seawater ph coral reefs defy ocean acidification odds in palau acquisition of dynamic function in human stem cell derived cells new hope for stem cell approach to treating diabetes browning of subcutaneous white adipose tissue in humans after severe adrenergic stress how common white fat can be turned into energy burning brown fat in humans disease spread in age structured populations with maternal age effects spread of ages is key to impact of disease animal study finds to what extent does the reporting behavior of the media regarding a celebrity suicide influence subsequent suicides in south korea ? media coverage of celebrity suicide can cause large scale copycat effect prenatal exposure to unconventional oil and gas operation chemical mixtures altered mammary gland development in adult female mice changes in mouse breast tissue after exposure to fracking chemicals environments and trypanosomiasis risks for early herders in the later holocene of the lake victoria basin kenya early herders grassy route through africa old teeth show lake victoria wasn t tsetse fly habitat snapshot serengeti high frequency annotated camera trap images of mammalian species in an african savanna largest ever scientific camera trapping survey reveals secret lives of the serengeti association between lowering ldl c and cardiovascular risk reduction among different therapeutic interventions study compares cv risk reduction of statin vs nonstatin therapies used for lowering ldl c counterfeit phosphodiesterase type inhibitors pose significant safety risks counterfeit internet drugs pose significant risks and discourage vital health checks amelioration of binge eating by nucleus accumbens shell deep brain stimulation in mice involves d receptor modulation binge eating curbed by deep brain stimulation in animal model identification of hemagglutinin residues responsible for h n antigenic drift during the influenza season scientists pinpoint mutations responsible for ineffectiveness of flu vaccine combined mutation in vhl trp and rb causes clear cell renal cell carcinoma in mice better treatment for kidney cancer thanks to new mouse model nonlinear heat effects on african maize as evidenced by historical yield trials untapped crop data from africa predicts corn peril if temperatures rise nestin regulates neurogenesis in mice through notch signaling from astrocytes to neural stem cells new insight into the process of generation of new neurons in the adult brain screening of biochemical and molecular mechanisms of secondary injury and repair in the brain after experimental blast induced traumatic brain injury in rats mild blast injury causes molecular changes in brain akin to alzheimer framingham risk score and the risk of progression from mild cognitive impairment to dementia vascular risk factors and alzheimer s disease a new therapeutic opportunity ? global estimation of surgical procedures needed for forcibly displaced persons unmet surgical needs high for world s million refugees structure mechanical stability relations of metal organic frameworks via machine learning machine learning predicts mechanical properties of porous materials arabidopsis thaliana ngatha transcription factor induces aba biosynthesis by activating nced gene during dehydration stress gene regulator that allows plant rehydration after drought repeatable group differences in the collective behaviour of stickleback shoals across ecological contexts shoals of sticklebacks differ in their collective personalities cell type specific abundance of ebp primes prostate cancer sensitivity or resistance to pi k pathway inhibitors researchers identify a new mode of drug resistance to emerging therapies in prostate cancer potential effects of replacing sedentary time with short sedentary bouts or physical activity on mortality a national cohort study physical activity any type or amount cuts health risk from sitting transform high seas management to build climate resilience in marine seafood supply high seas fisheries management could recoup losses due to climate change the association of combat exposure with postdeployment behavioral health problems among u.s. army enlisted women returning from afghanistan or iraq combat exposure may jeopardize the behavioral health of women in the military imaging activity in neurons and glia with a polr a based and cre dependent gcamp g ires tdtomato reporter mouse mouse model for epilepsy alzheimer s gives window into working brain dietary nitrate supplementation improves exercise performance and decreases blood pressure in copd patients beetroot juice improves exercise function of copd patients study shows paternal occupation and birth defects findings from the national birth defects prevention study certain jobs dads do linked to higher risk of birth defects il engages multiple mechanisms to overcome chronic viral infection and limit organ pathology boosting body s immune response may hold key to hiv cure long term dutasteride therapy in men with benign prostatic hyperplasia alters glucose and lipid profiles and increases severity of erectile dysfunction popular prostate drug linked to serious side effects a zymogen like factor xa variant corrects the coagulation defect in hemophilia bio engineered protein shows promise as new hemophilia therapy characterization and molecular profiling of psen familial alzheimer s disease ipsc derived neural progenitors stem cell research identifies new gene targets in patients with alzheimer s disease impact of flow diversion by run of river dams on american dipper diet and mercury exposure are elevated levels of mercury in the river birds due to run of river dams ? headache after pediatric traumatic brain injury a cohort study headaches after traumatic brain injury highest in adolescents and girls study finds effects of traditional chinese acupuncture in post viral olfactory dysfunction acupuncture may be an effective treatment for post viral infection loss of smell age of onset duration and type of medication therapy for attention deficit hyperactivity disorder and substance use during adolescence a multi cohort national study study highlights multiple factors of adhd medication use gene x environment interactions for adhd synergistic effect of httlpr genotype and youth appraisals of inter parental conflict adhd linked to interaction of genetics and psychology media violence and other aggression risk factors in seven nations cross cultural study strengthens link between media violence aggressive behavior the influence of individual partner and relationship factors on hiv testing in adolescents high hiv knowledge risky sexual behavior not associated with hiv testing in young adolescents penetrance of nod card genetic variants in the general population genetic variants associated with a risk of crohn s disease resolution agonist epi lipoxin a programs early activation of resolving phase in post myocardial infarction healing a bioactive molecule may protect against congestive heart failure after heart attacks comparative study of regulatory circuits in two sea urchin species reveals tight control of timing and high conservation of expression dynamics precise conservation of the dynamics of embryonic regulatory circuits plays key role in maintaining morphological similarity between species evidence of response to il inhibition in some cases of refractory spondyloarthritis associated peripheral synovitis table research opens up new treatment route for inflammatory rheumatism diagnostic value of nasal allergen challenge combined with radiography and ultrasonography in chronic maxillary sinus disease imaging tests identify role of allergies in chronic sinus disease a controlled trial of extended release guanfacine and psychostimulants for attention deficit hyperactivity disorder combination therapy shows positive response for children with adhd zooarchnet connecting zooarchaeological specimens to the biodiversity and archaeology data networks new data platform illuminates history of humans environmental impact humanized mice reveal differential immunogenicity of cells derived from autologous induced pluripotent stem cells study provides hope for some human stem cell therapies twelve weeks of supervised exercise improves self reported symptom burden and fatigue in chronic kidney disease a secondary analysis of the extra ckd trial exercise shown to improve symptoms of patients with chronic kidney disease subnanocatalysis for aerobic oxidation toluene oxidation with oxygen using subnano metal particles metallic nanoparticles light up another path towards eco friendly catalysts meeting instructional standards for middle level science which teachers are most prepared ? teachers lacking educational background in science use inquiry oriented instruction least making waves in the stream of consciousness entraining oscillations in eeg alpha and fluctuations in visual awareness with rhythmic visual stimulation heightened visual awareness by following brains natural rhythms ? role in tumor growth of a glycogen debranching enzyme lost in glycogen storage disease major genetic study links liver disease gene to bladder cancer early subthreshold aerobic exercise for sport related concussion concussion treatment adolescent athletes prescribed aerobic exercise recovered faster protective vaccination against papillomavirus induced skin tumors under immunocompetent and immunosuppressive conditions a preclinical study using a natural outbred animal model skin tumor vaccine shows promise in wild mice rising hope for transplant patients top predators determine how biodiversity is partitioned across time and space dragonflies reveal how biodiversity changes in time and space could chiggers be contributing to the prevalence of galactose alpha galactose sensitization and mammalian meat allergy ? allergists warn that chigger bites may cause allergic reaction to red meat grass invasion increases top down pressure on an amphibian via structurally mediated effects on an intraguild predator more wolf spiders feasting on american toads due to invasive grass study shows systematics of south american snail eating snakes serpentes dipsadini with the description of five new species from ecuador and peru five new species of snail sucking snakes discovered hippocampal contributions to model based planning and spatial memory first evidence for necessary role of human hippocampus in planning ablation of trip br a regulator of fat lipolysis thermogenesis and oxidative metabolism prevents diet induced obesity and insulin resistance researchers identify a new gene with a key role in obesity and diabetes inside the black box eu policy officers perspectives on transport and climate change mitigation emission reductions hampered by eu internal policy processes new research finds altered brain microstructure in association with repetitive subconcussive head impacts and the potential protective effect of jugular vein compression a longitudinal study of female soccer athletes neck device shows promise in protecting the brain of female soccer players the outcome of corneal transplantation in infants children and adolescents for some kids corneal transplant improves vision and daily life smoke free air laws and secondhand smoke exposure among nonsmoking youth nhanes smoke free air laws effective at protecting children from secondhand smoke silencing hoxa by intraductal injection of sirna lipidoid nanoparticles prevents mammary tumor progression in mice novel non invasive therapy prevents breast cancer formation in mice psychosis alters association between iq and future risk of attempted suicide cohort study of swedish men link identified between lower iq scores and attempted suicide in men increased risk of litigation associated with laser surgery by nonphysician operators lawsuits increasing over skin related laser surgery performed by non physicians adoption of hypofractionated whole breast irradiation for early stage breast cancer a national cancer data base analysis increased use of hypofractionated whole breast irradiation for patients with early stage breast cancer activity dependent transcriptional regulation of m type kv k channels by akap mediated nfat actions brake on nerve cell activity after seizures discovered gene expression initiates protective electrical response effect of mailing nicotine patches on tobacco cessation among adult smokers a randomized clinical trial mailed nicotine patches with no behavioral support associated with cessation differing effects of two synthetic phonics programmes on early reading development two synthetic phonics programs equally effective at teaching young children to read a missense change in the atg d gene links aberrant autophagy to a neurodegenerative vacuolar storage disease novel neurodegenerative disease and gene identified with the help of man s best friend health care costs associated with addition titration and switching antihypertensive medications after first line treatment results from a commercially insured sample one blood pressure drug therapy associated with lower health care costs long term use and follow up of irradiated homologous costal cartilage grafts in the nose use of rib cartilage grafts in rhinoplasty results in patient satisfaction few complications role models and the psychological characteristics that buffer low socioeconomic status youth from cardiovascular risk supportive role models coping lead to better health in poor teens host demise as a beneficial function of indigenous microbiota in human hosts commensal bacteria were critical shapers of early human populations tnf driven adaptive response mediates resistance to egfr inhibition in lung cancer double drug strategy blocks escape route for most lung cancers a galling insect activates plant reproductive programs during gall development insects hijack reproductive genes of grape vines to create own living space on plant altered mglur homer scaffolds and corticostriatal connectivity in a shank complete knockout model of autism mouse model of autism offers insights to human patients potential drug targets careful cachers and prying pilferers eurasian jays garrulus glandarius limit auditory information available to competitors hushed hoarders and prying pilferers eurasian jays change strategies to prevent others from stealing food inter comparison of multiple statistically downscaled climate datasets for the pacific northwest usa warmer future for the pacific northwest if carbon dioxide levels rise climate projections show eight years of colonoscopic bowel cancer screening in germany initial findings and projections. bowel cancer eight years of colonoscopy screening in germany pays off heterointerface engineered electronic and magnetic phases of ndnio thin films engineering new properties on ultra thin nanomaterials tool opens door for design of new phases of materials oxide heterostructures for high density d electron gases on gaas new oxide and semiconductor combination builds new device potential effect of providing conditional economic compensation on uptake of voluntary medical male circumcision in kenya study examines incentives to increase medical male circumcision to help reduce risk of hiv in kenya detection of replication competent lentivirus using a qpcr assay for vsv g a rapid alternative to standard safety tests for lentiviral vectors medical error the third leading cause of death in the us medical errors now third leading cause of death in united states vascular disease causing mutation smooth muscle actin r c dominantly suppresses functions of actin in human patient fibroblasts skin cell model advances study of genetic mutation linked to heart disease stroke risk assessment of the patient health system and population effects of xpert mtb rif and alternative diagnostics for tuberculosis in tanzania an integrated modelling approach novel modelling approach used to assess effectiveness of new diagnostics for tb biabooster online dna concentration and size profiling with a limit of detection of fg l and application to high sensitivity characterization of circulating cell free dna biabooster a more sensitive device for characterizing dna in blood circulation physiological and pathological population dynamics of circulating human red blood cells mathematical model of the life cycle of red blood cells may predict risk of anemia ligand independent epha signaling drives the adoption of a targeted therapy mediated metastatic melanoma phenotype mechanism leading to drug resistance metastasis in melanoma patients discovered a microfluidics platform for combinatorial drug screening on cancer biopsies miniature testing of drug pairs on tumor biopsies hypomethylation of the il rc promoter associates with age related macular degeneration immune system could play a central role in age related macular degeneration population level effectiveness of rapid targeted high coverage roll out of hiv pre exposure prophylaxis in men who have sex with men the epic nsw prospective cohort study prep implementation is associated with a rapid decline in new hiv infections genome scale transcriptional activation by an engineered crispr cas complex new way to turn genes on discovered technique allows rapid large scale studies of gene function water accessibility at hospitals in low and middle income countries implications for improving access to safe surgical care one third of hospitals in developing world lack running water universal access to hiv treatment versus universal test and treat transmission drug resistance treatment costs best strategy to defeat hiv in south africa study challenges world health organization s approach off fault focal mechanisms not representative of interseismic fault loading suggest deep creep on the northern san jacinto fault geoscientists find unexpected deep creep near san andreas san jacinto faults long term nutrient reductions lead to the unprecedented recovery of a temperate coastal region submerged aquatic vegetation return is sentinel of chesapeake bay ecosystem recovery higher prevalence of lymph node metastasis in prostate cancer in patients with diabetes prostate cancer poor prognosis in men with diabetes urine bisphenol a level in relation to obesity and overweight in school age children bpa linked to obesity risk in puberty age girls adult functional outcomes of common childhood psychiatric problems a prospective longitudinal study success in adulthood linked to childhood psychiatric health discovery of the fossil otter enhydritherium terraenovae carnivora mammalia in mexico reconciles a palaeozoogeographic mystery ancient otter tooth found in mexico suggests mammals migrated across america sumoylation of synapsin ia maintains synaptic vesicle availability and is reduced in an autism mutation new evidence linking brain mutation to autism epilepsy and other neuro disorders moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline longitudinal cohort study even moderate drinking linked to a decline in brain health finds study informing protection efforts for critically endangered chimpanzees pan troglodytes verus and sympatric mammals amidst rapid growth of extractive industries in senegal in developing nations national parks could save endangered species exchanging a few commercial regularly consumed food items with improved fat quality reduces total cholesterol and ldl cholesterol a double blind randomised controlled trial small dietary changes reduces cardiovascular disease risk by more than a quarter life long in vivo cell lineage tracing shows that no oogenesis originates from putative germline stem cells in adult mice researchers question treatment of infertility with stem cells how will dsm affect autism diagnosis ? a systematic literature review and meta analysis new autism definition may decrease diagnosis by one third dose of physical activity physical functioning and disability risk in mobility limited older adults results from the life study randomized trial small increases in physical activity reduce immobility disability risks in older adults potentially unsafe activities and living conditions of older adults with dementia study addresses safety concerns for older adults with diagnosed undiagnosed dementia a whole genome sequence study identifies genetic risk factors for neuromyelitis optica scientists unravel dna code behind rare neurologic disease modular cell internalizing aptamer nanostructure enables targeted delivery of large functional rnas in cancer cell lines specialized delivery methods to help treat cancer other disorders exploring how symptoms of attention deficit hyperactivity disorder are related to reading and mathematics performance general genes general environments over range of adhd behavior genes major force on reading achievement environment on math urbanization increases pathogen pressure on feral and managed honey bees urban environments boost pathogen pressure on honey bees microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type nf regulated glial proliferation brain cells hidden differences linked to potential cancer risk susceptibility to neurofibrillary tangles role of the ptprd locus and limited pleiotropy with other neuropathologies new gene discovered associated with tau a common form of brain pathology can an increase in celiac disease be attributed to an increase in the gluten content of wheat as a consequence of wheat breeding ? no clear evidence more gluten in new wheat is responsible for increase in celiac disease prolonged parental behaviour by males of limnonectes palavanensis boulenger a frog with possible sex role reversal extraordinary faithful father revealed by study of smooth guardian frog of borneo links between sediment consolidation and cascadia megathrust slip behaviour seafloor sediments appear to enhance earthquake and tsunami danger in pacific northwest repair of bone defects using a new biomimetic construction fabricated by adipose derived stem cells collagen i and porous beta tricalcium phosphate scaffolds successful repair of bone defects using novel tissue engineered bone graft salivary mucins protect surfaces from colonization by cariogenic bacteria salivary mucins play active role to fight cavities amyloid imaging with carbon labeled pittsburgh compound b for traumatic brain injury study examines amyloid deposition in patients with traumatic brain injury impact of melanoma on patients lives among survivors a dutch population based study influence of skin cancer on quality of life appears more substantial for women a prospective study of tea drinking temperature and risk of esophageal squamous cell carcinoma drinking hot tea linked with elevated risk of esophageal cancer cell free protein synthesis and assembly on a biochip cell on a chip reveals protein behavior in the future artifical cells may produce complex protein structures on demand high c photosynthetic capacity and high intrinsic water use efficiency underlies the high productivity of the bioenergy grass arundo donax giant reed is a photosynthetic outlier study finds trepanation procedures outcomes comparison of prehistoric peru with other ancient medieval and american civil war cranial surgery remarkable skill of ancient peru s cranial surgeons immediate initiation of antiretroviral therapy for hiv infection accelerates bone loss relative to deferring therapy findings from the start bone mineral density substudy a randomized trial early antiretroviral therapy linked with bone loss in patients with hiv hiv aids mortality attributable to smoking among hiv infected individuals a nationwide population based cohort study hiv patients in care lose more years of life to smoking than to hiv infection combinatorial discovery of defined substrates that promote a stem cell state in malignant melanoma chemical array draws out malignant cells to guide individualized cancer treatment generation of lung epithelial like tissue from human embryonic stem cells lung tissue generated from human embryonic stem cells a genome wide rnai screen identifies foxo as a metastasis suppressor through counteracting pi k akt signal pathway in prostate cancer new metastasis suppressor gene identified by cancer researchers meta analysis identifies additional ulcerative colitis risk loci increasing the number of confirmed associations to genome regions linked to common form of inflammatory bowel disease synthesis crystal structure analysis and electrochemical properties of rock salt type mgxniycozo as a cathode material for mg rechargeable batteries charging into the future novel rock salt for use in rechargeable magnesium batteries thinking outside the box unconstrained creative generation in adults with attention deficit hyperactivity disorder thinking outside the box adults with adhd not constrained in creativity risk of maternal mortality in women with severe anaemia during pregnancy and post partum a multilevel analysis risk of maternal death doubled in pregnant women with anemia adult human and mouse ovaries lack ddx expressing functional oogonial stem cells new studies question the treatment of female infertility with stem cells discovery of a new fundamental plane dictating galaxy cluster evolution from gravitational lensing uncovering the secret law of the evolution of galaxy clusters association of early life exposure to income inequality with bullying in adolescence in countries being bullied as a teen is associated with growing up in areas of income inequality alcohol in fatal crashes involving mexican and canadian drivers in the usa fatal crashes in the us fewer canadian drivers under the influence cultural diversity and saccade similarities culture does not explain saccade latency differences between chinese and caucasian participants faster eye responses in chinese people not down to culture study suggests impacts of nutrient enrichment on coral reefs new perspectives and implications for coastal management and reef survival importance of nutrients for coral reefs highlighted by scientists genomic tools for behavioural ecologists to understand repeatable individual differences in behaviour new guide for finding genes linked with behavior a beneficial role for immunoglobulin e in host defense against honeybee venom bee sting allergy could be a defense response gone haywire the image in the mirror and the number on the scale weight weight perceptions and adolescent depressive symptoms the image in the mirror and the number on the scale both count occupational health risks in cardiac catheterization laboratory workers healthcare workers radiation exposure tied to range of health problems face recognition accuracy of forensic examiners superrecognizers and face recognition algorithms face recognition experts perform better with ai as partner relationship between dietary n fatty acid intake and hypertension effect of glycated hemoglobin levels an intricate interaction dietary fatty acid intake influences hypertension risk a hybrid effectiveness implementation trial of an evidence based exercise intervention for breast cancer survivors new evidence that exercise therapy acupuncture benefit breast cancer survivors design and self assembly of simple coat proteins for artificial viruses artificial virus improves delivery of new generations of pharmaceuticals polyphenol rich strawberry extract prse shows in vitro and in vivo biological activity against invasive breast cancer cells study on mice demonstrates the action of strawberries against breast cancer distinctive microbiomes and metabolites linked with weight loss after gastric bypass but not gastric banding dramatic shift in gut microbes and their metabolites seen after weight loss surgery neurological complications of acute and chronic otitis media ear infections can lead to meningitis brain abscess and other neurological complications patterns of allergen sensitization and self reported allergic disease in parents of food allergic children moms and dads of kids with food allergies think they re allergic too changes in winter conditions impact forest management in north temperate forests muddy forests shorter winters present challenges for loggers asthma and posttraumatic stress symptoms to years following exposure to the world trade center terrorist attack intense prolonged exposure to world trade center attack linked to new health problems years later personality changes during the transition from cognitive health to mild cognitive impairment personality changes during transition to developing mild cognitive impairment dna methylation signatures follow preformed chromatin compartments in cardiac myocytes d folding of dna provides important epigenetic mechanisms in the formation of cardiac muscle cells pan cancer analysis of s phase enriched lncrnas identifies oncogenic drivers and biomarkers rna based therapy can reduce lung cancer in mouse models study finds freeze only versus fresh embryo transfer in a multicenter matched cohort study contribution of progesterone and maternal age to success rates elective freezing of ivf embryos linked to higher pregnancy rates in some cases intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient derived motor neurons patient stem cells help identify common problem in als advanced fabrication and properties of hybrid polyethylene tetraphalate fiber silica aerogels from plastic bottle waste researchers turn plastic bottle waste into ultralight supermaterial combined treatment with epigenetic differentiating and chemotherapeutic agents cooperatively targets tumor initiating cells in triple negative breast cancer triple therapy cocktail shrinks triple negative breast tumors sucrose non fermenting related kinase regulates both adipose inflammation and energy homeostasis in mice and humans enzyme shown to regulate inflammation and metabolism in fat tissue the metastasis associated gene encodes a host permissive factor for schistosomiasis a leading global cause of inflammation and cancer host mta gene is required for optimal survival of schistosome parasites a leading global cause of cancer impact of video games on plasticity of the hippocampus playing with your brain negative impact of some action video games the impact of communicating genetic risks of disease on risk reducing health behaviour systematic review with meta analysis communicating genetic disease risk has little or no impact on health related behavior detection of reduced susceptibility to chlorfenapyr and bifenthrin containing products in field populations of the bed bug hemiptera cimicidae some bed bugs show early signs of resistance to two common insecticides assessment of cardiovascular risk and preparticipation screening protocols in masters athletes the masters athlete screening study mass a cross sectional study even the fittest middle aged athletes can t outrun cardiovascular risk factors stillbirth should be given greater priority on the global health agenda stillbirth should be given greater priority on the global health agenda argue experts timing of global regression and microbial bloom linked with the permian triassic boundary mass extinction implications for driving mechanisms cold extermination one of greatest mass extinctions was due to an ice age and not to earth s warming reduced dietary intake of pro inflammatory toll like receptor stimulants favourably modifies markers of cardiometabolic risk in healthy men bacterial molecules discovered in processed foods could unlock key to healthier diets genetic signatures of microbial altruism and cheating in social amoebas in the wild arms races and cooperation among amoebae in the wild hypofractionated postmastectomy radiation therapy is safe and effective first results from a prospective phase ii trial three week radiation therapy treatment given post mastectomy is safe and effective delivery of rankl binding peptide op promotes bmp induced maxillary bone regeneration injected mix of bone augmenting agents causes new bone growth in mouse jaws screening for at risk drinking behavior in trauma patients questionnaire beats blood test in identifying at risk drinking among er patients genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast brewing yeasts reveal secrets of chromosomal warfare dysfunction factors influencing health and safety practices among vietnamese nail salon technicians and owners a qualitative study educational outreach public policy changes needed to reduce health hazards at nail salons a new turtle taxon podocnemidoidea bothremydidae reveals the oldest known dispersal event of the crown pleurodira from gondwana to laurasia the incredible journey of the first african tortoise that arrived in europe serious psychological distress and daily cannabis use to potential implications for mental health ? severe psychological distress and daily cannabis use implications for mental health ? cytokine release assays as tests for exposure to leishmania and for confirming cure from leishmaniasis in solid organ transplant recipients risk of developing leishmaniasis multiplies a hundredfold in transplant patients a comparison of in hospital mortality risk conferred by high hospital occupancy differences in nurse staffing levels weekend admission and seasonal influenza full house raises risk of hospital deaths study finds fasting mimicking diet modulates microbiota and promotes intestinal regeneration to reduce inflammatory bowel disease pathology fasting mimicking diet holds promise for treating people with inflammatory bowel disease the synchronous neural interactions test as a functional neuromarker for post traumatic stress disorder ptsd a robust classification method based on the bootstrap by measuring magnetic fields in brain researchers identify post traumatic stress disorder biomarker thirty fold extreme gravitational lensing of a quiescent galaxy at z. natural telescope new magnification record for magnification by gravitational lensing progression to traditional cigarette smoking after electronic cigarette use among us adolescents and young adults e cigarettes serve as gateway to smoking for teens young adults naturalistic driving study investigating self regulation behavior in early alzheimer s disease a pilot study naturalistic driving study investigates self regulation behavior in early alzheimer s disease polyglutamine expanded androgen receptor interferes with tfeb to elicit autophagy defects in sbma target identified for rare inherited neurological disease in men maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants pregnant women who eat peanuts may put infants at increased risk for peanut allergy study finds safety and benefit of discontinuing statin therapy in the setting of advanced life limiting illness discontinuing statins for patients with life limiting illness neural implementation of bayesian inference in a sensorimotor behavior circuit found for brain s statistical inference about motion acceptance of shaken baby syndrome and abusive head trauma as medical diagnoses shaken baby syndrome accepted as diagnosis by majority of physicians dual mode operation of neuronal networks involved in left right alternation different neuronal groups govern right left alternation when walking competing mindsets in entrepreneurship the cost of doubt the cost of doubt research examines competing mindsets in entrepreneurship genes related to sex steroids neural growth and social emotional behaviour are associated with autistic traits empathy and asperger syndrome asperger syndrome autism and empathy study links genes compartmented neuronal cultures reveal two distinct mechanisms for alpha herpesvirus escape from genome silencing hush little virus don t say a word how scientists investigate sleeping viruses transposon derived small rnas triggered by mir mediate genome dosage response in arabidopsis counting chromosomes plant scientists solve a century old mystery about reproduction mechanistic modeling quantifies the influence of tumor growth kinetics on the response to anti angiogenic treatment tumor growth parameters predict response to anti angiogenic therapy in mice diversity of management strategies in mesoamerican turkeys archaeological isotopic and genetic evidence not just for christmas study sheds new light on ancient human turkey relationship astrocytes negatively regulate neurogenesis through the jagged mediated notch pathway astrocytes control the generation of new neurons from neural stem cells impacts of the north and tropical atlantic ocean on the antarctic peninsula and sea ice north and tropical atlantic ocean bringing climate change to antarctica pedestrians struck by motor vehicles further worsen race and insurance based disparities in trauma outcomes the case for inner city pedestrian injury prevention programs race insurance status cited in uneven death rates among pedestrians hit by cars environmental impacts of the u.s. health care system and effects on public health environmental health impacts of us health care system intestinal microbiota modulates gluten induced immunopathology in humanized mice gut microorganisms cause gluten induced pathology in mouse model of celiac disease paired studies comparing clinical profiles of lewy body dementia with alzheimer s and parkinson s diseases trial helps doctors tell lewy body dementia from alzheimer s parkinson s s p dependent trafficking of intracellular yersinia pestis through lymph nodes establishes buboes and systemic infection new insights on an ancient plague could improve treatments for infections tundra soil carbon is vulnerable to rapid microbial decomposition under climate warming study of tundra soil demonstrates vulnerability of ecosystem to climate warming accelerated increase in plant species richness on mountain summits is linked to warming increase of plant species on mountain tops is accelerating with global warming crispr cas mediated gene editing in human tripronuclear zygotes world s first genetic modification of human embryos reported experts consider ethics cell specific pallidal intervention induces long lasting motor recovery in dopamine depleted mice neuronal targets to restore movement in parkinson s disease model fine scale spatial patterns of parrotfish herbivory are shaped by resource availability farming fish marine biologists identify movement patterns of a parrotfish species that rotationally harvests its favorite algae defends its feeding territory automated tubule nuclei quantification and correlation with oncotype dx risk categories in er breast cancer whole slide images computerized tissue image analysis reveals underlying genomics of er breast cancer a ketone alcohol polymer for cycle of electrolytic hydrogen fixing with water and releasing under mild conditions hydrogen in your pocket ? new plastic for carrying and storing hydrogen infant transmitted founder hiv viruses from peripartum transmission are neutralization resistant to paired maternal plasma hiv viruses transmitted at birth are resistant to antibodies in mother s blood vascular repair after firearm injury is associated with increased morbidity and mortality vascular surgery after firearm injury associated with increased morbidity and mortality phenotypic assessment of pulmonary hypertension using high resolution echocardiography is feasible in neonatal mice with experimental bronchopulmonary dysplasia and pulmonary hypertension a step toward preventing chronic obstructive pulmonary disease early echocardiography to study pulmonary hypertension in mouse model of bronchopulmonary dysplasia herpes zoster vaccine effectiveness against incident herpes zoster and post herpetic neuralgia in an older us population a cohort study shingles vaccine is associated with reduction in both postherpetic neuralgia and herpes zoster a new genus and species of arboreal toad with phytotelmonous larvae from the andaman islands india lissamphibia anura bufonidae new tiny arboreal toad species from india is just small enough for its own genus diversity oriented biosynthesis via accelerated evolution of modular gene clusters landmark discovery turns marathon of evolution into a sprint acupuncture at st prevents chronic stress induced increases in neuropeptide y in rat acupuncture reduces protein linked to stress in first of its kind animal study alcohol consumption during adolescence in a mouse model of binge drinking alters the intrinsic excitability and function of the prefrontal cortex through a reduction in the hyperpolarization activated cation current adolescent binge drinking disrupts mouse memory in adulthood relationship between physical occupational exposures and health on semen quality data from the longitudinal investigation of fertility and the environment life study physical labor hypertension and multiple meds may reduce male fertility training and standards for performance interpretation and structured reporting for supplemental breast cancer screening ultrasound lags behind mri for supplemental breast cancer screening sunbed use user characteristics and motivations for tanning results from the german population based sun study study identifies characteristics of sunbed users motivation for tanning acute exercise remodels promoter methylation in human skeletal muscle exercise and caffeine change your dna in the same way study suggests risk of brain tumors from wireless phone use does long term cell phone use lead to brain tumors ? gender in differences in prevalence and incidence of traumatic experiences among orphaned and separated children living in five low and middle income countries orphaned boys as vulnerable to abuse as girls dendritic spine instability leads to progressive neocortical spine loss in a mouse model of huntington s disease new clue on the origin of huntington s disease an hla drb coded signal transduction ligand facilitates inflammatory arthritis a new mechanism of autoimmunity gene s role in rheumatoid arthritis uncovered findings pave way for new treatments fast compressive raman bio imaging via matrix completion researchers use algorithm from netflix challenge to speed up biological imaging generation of germline ablated male pigs by crispr cas editing of the nanos gene pig gene advance could boost sperm stocks from prized animals prognostic implication of persistent human papillomavirus type dna detection in oral rinses for human papillomavirus related oropharyngeal carcinoma hpv detection in oral rinses for oropharyngeal cancer early pregnancy weight gain exerts the strongest effect on birth weight posing a critical time to prevent childhood obesity early weight gain in pregnancy correlates with childhood obesity first study of its size shows from the junkyard to the power grid ambient processing of scrap metals into nanostructured electrodes for ultrafast rechargeable batteries shoring up the power grid with diy scrap metal batteries in vitro efficacy and risk for adverse effects of light assisted tooth bleaching uv light enhanced tooth bleaching dangerous to eyes and skin study shows tissue engineered intervertebral discs produce new matrix maintain disc height and restore biomechanical function to the rodent spine in the battle to relieve back aches researchers create bioengineered spinal disc implants a year retrospective analysis of the epidemiology and outcomes for elderly emergency general surgical admissions in the north east of england a case for multidisciplinary geriatric input elderly emergency surgery admissions mortality risk in uk has improved percent last years n and b codoped graphene a strong candidate to replace natural peroxidase in sensitive and selective bioassays nanomaterials mimicking natural enzymes with superior catalytic activity and selectivity decay in survival motor neuron and plastin levels during differentiation of ipsc derived human motor neurons new stem cell research uncovers causes of spinal muscular atrophy flyception imaging brain activity in freely walking fruit flies first peek into the brain of a freely walking fruit fly tunable semiconductors control over carrier states and excitations in layered hybrid organic inorganic perovskites supercomputer predicts optical properties of complex hybrid materials embodied health the effects of a mind body course for medical students mind body course has positive impact on well being of medical students restoring tip hat hdac balance in the neurodegenerative brain relieves epigenetic transcriptional repression and reinstates cognition restoring epigenetic balance reinstates memory in flies with alzheimer s disease symptoms experimental cerebral malaria pathogenesis hemodynamics at the blood brain barrier blood pressure build up from white blood cells may cause cerebral malaria death genomic evidence for shared common ancestry of east african hunting gathering populations and insights into local adaptation a shared past for east africa s hunter gatherers a biological switching valve evolved in the female of a sex role reversed cave insect to receive multiple seminal packages novel switching valve to receive more semen in a sex role reversed cave insect activated protein c therapy slows als like disease in mice by transcriptionally inhibiting sod in motor neurons and microglia cells compound shows potential for slowing progression of lou gehrig s disease the hispanic americans baseline alcohol survey hablas alcoholic beverage preference across hispanic national groups us hispanics prefer beer to other alcoholic beverages study finds enrichment of oral microbiota in early cystic precursors to invasive pancreatic cancer oral bacteria in pancreas linked to more aggressive tumors atlantic forcing of persistent drought in west africa mega droughts in sub saharan africa normal for region droughts likely to worsen with climate change cross national variation in determinants of climate change concern commitment to democratic values predict climate change concern study finds indirect learning how emerging market firms grow in developed markets how do emerging market firms compete in developed markets ? the case of india past penguin colony responses to explosive volcanism on the antarctic peninsula antarctic penguin colony repeatedly decimated by volcanic eruptions development of an objective autism risk index using remote eye tracking remote eye gaze tracking as a marker for autism ion mobility conformational lipid atlas for high confidence lipidomics new lipid shape atlas holds key to early disease detection did alexander the great die from guillain barr syndrome ? new explanation for alexander the great s death adolescent loss of control eating and weight loss maintenance after bariatric surgery loss of control eating and bariatric surgery success failure of stem cell therapy to improve vision in children with optic nerve hypoplasia no evidence to support stem cell therapy for pediatric optic nerve hypoplasia a highly magnetized twin jet base pinpoints a supermassive black hole twin jets pinpoint the heart of an active galaxy t cell derived interleukin il promotes brain injury following stroke in mice halting immune response could save brain cells after stroke long term follow up of quality of life following diep flap breast reconstruction good long term quality of life after diep flap breast reconstruction randomized controlled trial of increasing physical activity on objectively measured and self reported cognitive functioning among breast cancer survivors the memory motion study brain powered increased physical activity among breast cancer survivors boosts cognition yield stability of heirloom dry bean phaseolus vulgaris l. cultivars in midwest organic production heirloom dry beans suitable for small scale organic production smart swarms of bacteria inspired agents with performance adaptable interactions smart swarms of bacteria inspire robotics adaptable decision making found in bacteria communities national regional and global trends in infertility prevalence since a systematic analysis of health surveys global rates of infertility remain unchanged over past decades hsv co infection as a driver of hiv transmission among heterosexual non injecting drug users in new york city herpes virus infection drives hiv infection among non injecting drug users in new york comparative evaluation of immunochemical fecal occult blood tests for colorectal adenoma detection colorectal cancer immunological tests for more accurate detection of cancer precursors adseverin plays a role in osteoclast differentiation and periodontal disease mediated bone loss protein adseverin identified as key factor driving bone loss in osteoinflammatory disease human genomic signatures of brain oscillations during memory encoding scientists identify memory genes open new avenues of brain study aqueous processing for printed organic electronics conjugated polymers with multistage cleavable side chains spray on electric rainbows making safer electrochromic inks maternal intake of supplemental iron and risk for autism spectrum disorders mothers of children with autism less likely to have taken iron supplements in pregnancy study shows an artificial bee colony algorithm search guided by scale free networks searching an artificial bee colony for real world results m muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss alzheimer s advance early stage study in mice show new drugs restore memory loss and prolong life a microbial survey of the international space station iss the bacterial community on the international space station resembles homes diagnosis of tuberculosis using colorimetric gold nanoparticles on a paper based analytical device paper based tuberculosis test could boost diagnoses in developing countries genome wide analyses of chip seq derived foxa dna occupancy in liver points to genetic networks underpinning multiple complex traits endocrine related protein found to be master regulator in other important diseases infection of eight mesocarnivores in new hampshire and vermont with a distinct clade of canine distemper virus in new strain of canine distemper in wild animals in nh vt preparing for adulthood health care transition counseling for youth with arthritis adolescents with arthritis need more information when transitioning to adult care health related quality of life of u.s. adults with arthritis analysis of data from the behavioral risk factor surveillance system and adults with arthritis suffer with poorer health related quality of life ocean acidification and control of reef coral calcification by boundary layer limitation of proton flux proton flux hypothesis offers new explanation for effects of ocean acidification on coral reefs early intervention for symptomatic youth at risk for bipolar disorder a randomized trial of family focused therapy family intervention improves mood symptoms in children and adolescents at risk for bipolar disorder analyzing whether countries are equally efficient at improving longevity for men and women health spending more efficient for men than women bacterial derived exopolysaccharides enhance antifungal drug tolerance in a cross kingdom oral biofilm bacteria boost antifungal drug resistance in severe childhood tooth decay circulating tumor cells predict survival in early average to high risk breast cancer patients tumor cells in blood may indicate poor prognosis in early breast cancer an mrna vaccine protects mice against multiple tick transmitted flavivirus infections a versatile vaccine that can protect mice from emerging tick borne viruses effect of a strategy of initial laryngeal tube insertion vs. endotracheal intubation on hour survival in adults with out of hospital cardiac arrest a randomized clinical trial more patients survive sudden cardiac arrest with new ems technique that uses a breathing tube identification of a small molecule with activity against drug resistant and persistent tuberculosis new compound excels at killing persistent and drug resistant tuberculosis holocene winter climate variability in central and eastern europe ice cave in transylvania yields window into region s past a novel microbiome therapeutic increases gut microbial diversity and prevents recurrentclostridium difficileinfection oral capsule with bacterial spores may be effective treatment for recurrent c. difficile progenitor and terminal subsets of cd t cells cooperate to contain chronic viral infection molecular root of exhausted t cells in chronic viral infection the grass isn t always greener the effects of cannabis on embryological development with worrisome animal research more focus needed on effects of cannabis on human development the greenscape shapes surfing of resource waves in a large migratory herbivore migrating mule deer track green waves of spring forage single cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse embryonic stem cells long held assumption of gene expression in embryonic stem cells challenged neural mechanisms of improvements in social motivation after pivotal response treatment two case studies early treatment sparks striking brain changes in autism fxr p limits long term memory long lasting synaptic potentiation and de novo glua translation the science behind total recall new player in brain function and memory low dose aspirin for primary prevention of cardiovascular events in japanese patients years or older with atherosclerotic risk factors effect of once daily low dose aspirin on cardiovascular death other outcomes determinants and consequences of financial hardship among adult survivors of childhood cancer a report from the st. jude lifetime cohort study financial checkup should be part of health screenings for childhood cancer survivors drosophila rugose is a functional homolog of mammalian neurobeachin and affects synaptic architecture brain morphology and associative learning fruit flies bred without neurobeachin protein to facilitate study of nervous system diseases in humans integrating treatment at the intersection of opioid use disorder and infectious disease epidemics in medical settings a call for action after a national academies of sciences engineering and medicine workshop routine coordinated treatment of opioid abuse can stem national epidemic assessing the airborne survival of bacteria in populations of aerosol droplets with a novel technology assessing the airborne survival of bacteria in aerosol droplets from coughs and sneezes mutual antagonism of t cells causing psoriasis and atopic eczema fault in immune memory causes atopic eczema and psoriasis study finds omega and omega intake modifies asthma severity and response to indoor air pollution in children omega and omega fatty acids may play opposite roles in childhood asthma iodegradable plastic blends create new possibilities for end of life management of plastics but they are not a panacea for plastic pollution biodegradable plastic blends offer new options for disposal hotspots of climate change impacts in sub saharan africa and implications for adaptation and development hotspots of climate change impacts in africa making sense of uncertainties assessing vaccination sentiments with online social media implications for infectious disease dynamics and control twitter data used to track vaccination rates and attitudes resveratrol increases bone mineral density and bone alkaline phosphatase in obese men a randomized placebo controlled trial resveratrol boosts spinal bone density in men with metabolic syndrome structural determinants of adolescent girls vulnerability to hiv views from community members in botswana malawi and mozambique structural factors integral to understanding girls vulnerability to hiv in sub saharan africa chronic obstructive pulmonary disease and association with mild cognitive impairment the mayo clinic study of aging chronic lung disease linked to cognitive impairment memory loss the potential threat of acetyl fentanyl legal issues contaminated heroin and acetyl fentanyl disguised as other opioids quasi legal drug times stronger than heroin hides in plain sight abuse during childhood and adolescence and risk of adult onset asthma in african american women abuse during childhood linked to adult onset asthma in african american women proinflammatory cytokines enhance estrogen dependent expression of the multidrug transporter gene abcg through estrogen receptor and nf ?b cooperativity at adjacent response elements clue to unusual drug resistant breast cancers found brief report pilot study of a novel interactive digital treatment to improve cognitive control in children with autism spectrum disorder and co occurring adhd symptoms can a video game based digital medicine help children with autism and co occurring adhd ? use of diffusion tensor imaging in glioma resection personalized brain mapping technique preserves function following brain tumor surgery impact of medicaid expansion on medicaid covered utilization of buprenorphine for opioid use disorder treatment medicaid expansion linked to increased prescribing of buprenorphine for opioid use disorder treatment dynamic range adaptation in primary motor cortical populations motor neurons adjust to control tasks new brain research reveals the lichen genus phylloblastia verrucariaceae in the iberian peninsula with a new species from western europe new species of lichen discovered in iberian peninsula predicting the responses of native birds to transoceanic invasions by avian brood parasites invasive brood parasites a threat to native bird species n methyladenosine rna modification regulates embryonic neural stem cell self renewal through histone modifications discovery may advance neural stem cell treatments for brain disorders risk factors for pregnancy associated stroke in women with preeclampsia infections other factors raise risk of pregnancy related stroke in women with preeclampsia sound velocity of casio perovskite suggests the presence of basaltic crust in the earth s lower mantle fate of the subducted oceanic crust revealed by laboratory experiments vertical distributions of coccolithophores pic poc biogenic silica and chlorophyll a throughout the global ocean new satellite method enables undersea estimates from space in vitro analog of human bone marrow from d scaffolds with biomimetic inverted colloidal crystal geometry artificial human bone marrow created in a test tube xct slc a mediated metabolic reprogramming promotes non small cell lung cancer progression drug s impact on amino acid transporter may offer non small cell lung cancer patients new hope the importance of model systems why we study a virus on the brink of global eradication on the brink of eradication why polio research matters genome wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease cause of mysterious food allergy found new treatment strategy suggested larval fish dispersal in a coral reef seascape travel distances of juvenile fish key to better conservation the down syndrome biomarker initiative dsbi pilot proof of concept for deep phenotyping of alzheimer s disease biomarkers in down syndrome down syndrome research untangles therapeutic possibilities for alzheimer s posterior reversible encephalopathy syndrome associated with licorice consumption a case report in a year old boy licorice manufacturers encouraged to state daily limit of consumption vaccine mediated protection against zika virus induced congenital disease vaccines protect fetuses from zika infection mouse study shows the association between military sexual stress and psychiatric symptoms after controlling for other stressors childhood maltreatment high magnitude stressors are stronger predictors of psychiatric symptoms than military sexual stressors incorporation of membrane bound mammalian derived immunomodulatory proteins into influenza whole virus vaccines boosts immunogenicity and protection against lethal challenge virologists developing more potent vaccine technology that could apply to many viruses two chemically similar stellar overdensities on opposite sides of the plane of the galactic disk stars around the milky way cosmic space invaders or victims of galactic eviction ? subduction locking and fluid pressure distribution correlate before the chile earthquake great earthquakes water under pressure high risk research reveals interactions between plate tectonics fluids and quakes spdef is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production scientists identify gene for short circuiting excess mucus in lung disease common colds secondary metabolites monoterpene polyketides containing a spiro. nonane from cryptocarya laevigata australian shrub contains new class of organic compound developments in the framing of climate change as a public health issue in us newspapers how to engage the population with climate change ? frame it as a public health issue crowdsourcing reproducible seizure forecasting in human and canine epilepsy crowdsourcing contest using data from people dogs advances epileptic seizure forecasting genome wide target specificities of crispr cas nucleases revealed by multiplex digenome seq new tool for efficiently validating the accuracy of crispr cas reactions aza rubottom oxidation synthetic access to primary aminoketones nitrogen gets in the fast lane for chemical synthesis nucleotide excision repair is a predictor of early relapse in pediatric acute lymphoblastic leukemia genetic marker predictor of early relapse in pediatric all uncovered response of macrobenthic communities to the toarcian oceanic anoxic event in northeastern panthalassa ya ha tinda alberta canada fossil site shows impact of early jurassic s low oxygen oceans multiproxy evidence highlights a complex evolutionary legacy of maize in south america scientists overhaul corn domestication story with multidisciplinary analysis biochemical characterization of metabolism based atrazine resistance in amaranthus tuberculatus and identification of an expressed gst associated with resistance new gene for atrazine resistance identified in waterhemp why is the crowd divided ? attribution for dispersion in online word of mouth a matter of taste when do products benefit from mixed reviews ? thermoresponsive gel embedded with adipose stem cell derived extracellular vesicles promotes esophageal fistula healing in a thermo actuated delivery strategy cellular dust provides new hope for regenerative medicine the baltic sea as a time machine for the future coastal ocean a small sea as a model region for the global coastal ocean the association of overjet size and traumatic dental injuries a systematic review and meta analysis protect protruding teeth from damage and long term consequences brain micro inflammation at specific vessels dysregulates organ homeostasis via the activation of a new neural circuit chronic stress induces fatal organ dysfunctions via a new neural circuit early childhood behavior problems and the gender gap in educational attainment in the united states early behavior problems impact long term educational attainment more for boys than girls triple dissociation of attention networks in stroke according to lesion location computer test reveals high prevalence of attention disorders in stroke patients reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats brain study paves way for therapy for common cause of dementia in vivo genome editing using staphylococcus aureus cas crispr toolbox more versatile highly efficient new cas identified for in vivo genome editing the hmgb rage axis mediates traumatic brain injury induced pulmonary dysfunction in lung transplantation researchers isolate inflammatory process that damages lungs of donors with traumatic brain injury green tea epigallocatechin gallate egcg promotes neural progenitor cell proliferation and sonic hedgehog pathway activation during adult hippocampal neurogenesis brainy beverage study reveals how green tea boosts brain cell production to aid memory isolation and characterization of h n viruses from live poultry markets implication of the source of current h n infection in humans bird flu in live poultry markets are the source of viruses causing human infections effects of febuxostat in early gout a randomized double blind placebo controlled study febuxostat prevents gout flares in recent clinical trial gut microbiota dependent trimethylamine n oxide tmao pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease gut bacteria byproduct linked to chronic kidney disease for the first time hybrid speciation leads to novel male secondary sexual ornamentation of an amazonian bird first ever hybrid bird species from the amazon density and proximity of fast food restaurants and body mass index among african americans body mass index of low income african americans linked to proximity of fast food restaurants patterns and timing of sunlight exposure and risk of basal cell and squamous cell carcinomas of the skin a case control study how patterns and timing of sunlight exposure contribute to skin cancers different outdoor professions have different risks a cross sectional study comparing non melanoma skin cancer risk among farmers gardeners and mountain guides different outdoor professions carry different risks for skin cancer a smartphone application to support recovery from alcoholism smartphone app helps support recovery after treatment for alcoholism incidence and risk factors for hypertension among hiv patients in rural tanzania a prospective cohort study high prevalence incidence of hypertension among rural africans living with hiv neutralization of clostridium difficile toxin a with single domain antibodies targeting the cell receptor binding domain hospital infections unique antibody from llamas provide weapon against clostridium difficile anxiety and chronic couple relationship stress moderate adrenocortical response to couple interaction in expectant parents expectant parents have different stress reactions to relationship conflict use of tray applied percent carbamide peroxide gels for improving oral health in patients with special care needs tray bleaching may improve oral health of elderly special needs patients identification of a novel distal regulatory element of the human neuroglobin gene by the chromosome conformation capture approach genetic switch identified as potential target for alzheimer s disease peptides of presenilin bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce amyloid in alzheimer s disease novel approach blocks amyloid production in alzheimer s mouse model the feronia receptor kinase maintains cell wall integrity during salt stress through ca signaling plant survival under high salinity plant cell wall sensing mechanism long term risk of atrial fibrillation after the death of a partner death of partner linked to heightened risk of irregular heartbeat for up to a year later anatomical integration of the sacral hindlimb unit coordinated by gdf underlies variation in hindlimb positioning in tetrapods mechanisms explaining positional diversity of the hindlimb in tetrapod evolution fasting mimicking diet reduces ho to promote t cell mediated tumor cytotoxicity strategies to mimic fasting during chemotherapy enhance anticancer t cell activity in mice protracted volcanism after large impacts evidence from the sudbury impact basin ancient meteorite impact sparked long lived volcanic eruptions on earth systematic analysis of tumour cell extracellular matrix adhesion identifies independent prognostic factors in breast cancer study links two genes to breast cancer survival brain modulyzer interactive visual analysis of functional brain connectivity brain modulyzer provides interactive window into the brain once weekly dalbavancin versus daily conventional therapy for skin infection new antibiotic proven effective to treat acute bacterial skin infections early severe inflammatory responses to uropathogenic e. coli predispose to chronic and recurrent urinary tract infection immune system overreaction may enable recurrent urinary tract infections a comparison of intravenous lipid emulsions interim analysis of a randomized controlled trial benefits of combo lipid emulsion no greater than soy based emulsion for pediatric patients development of a brief parent report screen for common gastrointestinal disorders in autism spectrum disorder in kids with autism short questionnaire may detect gi disorders women s health periodontitis and its relation to hormonal changes adverse pregnancy outcomes and osteoporosis gum disease joins hot flashes and pms associated with women s hormones study of fish products in metro vancouver using dna barcoding methods reveals fraudulent labeling twenty five per cent of seafood sold in metro vancouver is mislabelled maternal tobacco cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring smoking during pregnancy puts children at risk of psychotic symptoms kidney function after the first kidney stone event research connects first time kidney stone formers and chronic kidney disease incidental findings in the cervical spine at ct for trauma evaluation incidental findings in trauma patients spark concerns for physicians axonal remodeling of the corticospinal tract in the spinal cord contributes to voluntary motor recovery after stroke in adult mice regenerating spinal cord fibers may be treatment for stroke related disabilities eight new species of charinus simon arachnida amblypygi charinidae endemic for the brazilian amazon with notes on their conservational status eight new species of whip spider found in the brazilian amazon social and financial resources and high risk alcohol consumption among older adults social factors can both predict and sustain alcohol misuse among older drinkers a multicenter prospective comparative effectiveness study of the effect of physician certification and center accreditation on patient centered outcomes in obstructive sleep apnea specialized care improves treatment outcomes in patients with sleep apnea yellow fever cases in asia primed for an epidemic yellow fever epidemic threatens to spread from angola to china pharmacokinetics and efficacy of pegylated liposomal doxorubicin in an intracranial model of breast cancer research shows advantage to nanotech delivery of therapy for breast cancer brain metastases direct powering a real cardiac pacemaker by natural energy of a heartbeat powering a pacemaker with a patient s heartbeat biofeedback is superior to electrogalvanic stimulation and massage for treatment of levator ani syndrome biofeedback more effective than egs and massage for chronic rectal pain study finds administration of autologous bone marrow stem cells into spinal cord injury patients via multiple routes is safe and improves their quality of life comprehensive case studies stem cell administration study demonstrates improved quality of life for patients suffering from spinal cord injury antibiotic and acid suppression medications during early childhood are associated with obesity childhood antibiotics and antacids may be linked to heightened obesity risk tyrannosaur paleobiology new research on ancient exemplar organisms tyrannosaurus redux t. rex was more than just a large carnivore at top of food chain new findings reveal cumulative alkylating agent exposure and semen parameters in adult survivors of childhood cancer a report from the st jude lifetime cohort study improved risk identification will aid fertility preservation in young male cancer patients lower bounds on ground motion at point reyes during the san francisco earthquake from train toppling analysis toppled train offers insight into ground motion origin of earthquake enrichment of risk snps in regulatory regions implicate diverse tissues in parkinson s disease etiology indicators of parkinson s disease risk found in unexpected places clinical follow up compared with self assessment of outcome after medical abortion a multicentre non inferiority randomised controlled trial research on medical abortion miscarriage may change international routines the use of cell transplantation in spinal cord injuries benefits of stem cells for treating spinal cord injuries assessed inactivation of medial frontal cortex changes risk preference gambling monkeys help scientists find brain area linked to high risk behavior stability of iron bearing carbonates in the deep earth s interior scientists shed light on carbon s descent into the deep earth vitamin supplementation by gut symbionts ensures metabolic homeostasis in an insect host the nutritionists within firebugs depend on gut bacteria for vitamin supply dosage dependent phenotypes in models of p. lesions found in autism evidence found for the genetic basis of autism models of autism show that gene copy number controls brain structure and behavior in viv o brain glycine and glutamate concentrations in patients with first episode psychosis measured by echo time averaged proton mr spectroscopy at tesla brain chemical abnormalities in earliest stage of psychosis identified pre hospital advanced airway management for adults with out of hospital cardiac arrest nationwide cohort study ecg rhythm and airway management make all the difference during a heart attack opinion governing the recreational dimension of global fisheries fishing for fun not food study takes stock of recreational fishing impacts tp mutations detected in circulating tumor cells present in the blood of metastatic triple negative breast cancer patients circulating tumor cells provide genomic snapshot of breast cancer road traffic noise is associated with increased cardiovascular morbidity and mortality and all cause mortality in london road traffic noise linked to deaths increased strokes reconstructing the evolution of giant extinct kangaroos comparing the utility of dna morphology and total evidence tiny australian wallaby the last living link to extinct giant kangaroos hydrochlorothiazide use and risk of non melanoma skin cancer a nationwide case control study from denmark popular blood pressure medicine linked with increased risk of skin cancer connectivity across the caribbean sea dna barcoding and morphology unite an enigmatic fish larva from the florida straits with a new species of sea bass from deep reefs off cura ao unusual fish larva linked to new species of sea bass from curacao climber climatic niche characteristics of the butterflies in europe unique new dataset climber climatic niche characteristics of the butterflies in europe contemporary range expansion of the virginia opossum didelphis virginiana impacted by humans and snow cover climate change urbanization driving opossum s northward march fishery independent data reveal negative effect of human population density on caribbean predatory fish communities sobering decline of caribbean s big fish fisheries overfishing deemed most likely cause estimation of the number of people with down syndrome in the united states numbers of people with down syndrome in the us since estimated clines on the seashore the genomic architecture underlying rapid divergence in the face of gene flow genetic toolkit helps periwinkles gain advantage on the seashore evaluation of the safety and immunogenicity of a candidate pandemic live attenuated influenza vaccine plaiv against h n influenza prime boost h n influenza vaccine concept promising in clinical trial spermidine suppresses age associated memory impairment by preventing adverse increase of presynaptic active zone size and release keeping your synapses sharp how spermidine reverses age related memory decline vital exhaustion and incidence of dementia results from the copenhagen city heart study psychological distress is a risk factor for dementia a role for rhesus factor rhcg in renal ammonium excretion and male fertility rhesus factor controls renal function and male fertility surgical outcomes of total knee replacement according to diabetes status and glycemic control to patients with diabetes at no greater risk for infection or other complications after total knee replacement inhibition of nipah virus infection in vivo targeting an early stage of paramyxovirus fusion activation during viral entry potential new treatment for deadly nipah and hendra viruses may also lead to new treatments for measles mumps and influenza individualized systems medicine ism strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia systems medicine paves way for improved treatment for leukemia patients the cape ann earthquake recorded in lake sediments of eastern new england an interdisciplinary paleoseismic approach sediment core from sluice pond contains evidence for new england earthquake sex differences in risk of hospitalization among emergency department patients with acute asthma women hospitalized percent more than men after emergency asthma treatment antiretroviral regimens in pregnancy and breast feeding in botswana aids drugs given to pregnant women block percent of hiv transmission to breastfed babies evidence for superconductivity above k in lanthanum superhydride at megabar pressures new evidence of superconductivity at near room temperature clostridium difficile colonization in early infancy is accompanied by changes in intestinal microbiota composition c. difficile colonization accompanied by changes in gut microbiota study hints at probiotics as treatment effect of ageing on cervical or vaginal cancer in swedish women previously treated for cervical intraepithelial neoplasia grade population based cohort study of long term incidence and mortality cervical vaginal cancer higher in women previously treated for pre cancerous cells on cervix study finds patterns of breast magnetic resonance imaging use in community practice use of breast mri increasingly aligned with most effective care site specific phosphorylation of tau inhibits amyloid toxicity in alzheimers mice discovery opens door to new alzheimer s treatments geographic disparities in availability of opioid use disorder treatment for medicaid enrollees more access to opioid treatment programs needed in southeast says study knowledge sharing networks in hunter gatherers and the evolution of cumulative culture tracing the path of pygmies shared knowledge of medicinal plants control of movement initiation underlies the development of balance balance may rely on the timing of movement rapid niche expansion by selection on functional genomic variation after ecosystem recovery more diversity than before indications for recovery after ecosystem pollution widespread transneuronal propagation of synucleinopathy triggered in olfactory bulb mimics prodromal parkinson s disease new model recreates early spread of parkinson s disease in the brain severe mental disorders in offspring with psychiatrically ill parents offspring of two psychiatric patients have increased risk of developing mental disorders historical climate controls soil respiration responses to current soil moisture historical rainfall levels are significant in carbon emissions from soil early caffeine administration and neurodevelopmental outcomes in preterm infants developing brains of premature babies benefit from caffeine therapy tedizolid phosphate vs linezolid for treatment of acute bacterial skin and skin structure infectionsthe establish randomized trialtreatment of skin and skin structure infections newer shorter course antibiotic shows similar effectiveness for treating skin infection public health and economic consequences of vaccine hesitancy for measles in the united states potential public health economic consequences of declining childhood vaccination mental and physical health of children in foster care foster care children at much greater risk of physical mental health problems the immunogenicity and safety of a quadrivalent live attenuated influenza vaccine in children children better protection from influenza with improved vaccine functional limits of agreement applied as a novel method comparison tool for accuracy and precision of inertial measurement unit derived displacement of the distal limb in horses important step forward for gait analysis of horses deep sea bioluminescence blooms after dense water formation at the ocean surface bioluminescence reveals deep water motion in the mediterranean high parathyroid hormone level and osteoporosis predict progression of coronary artery calcification in patients on dialysis hormone bone tests may be indicative of dialysis patients heart health cystic fibrosis and crohn s disease successful treatment and long term remission with infliximab cystic fibrosis and crohn s disease treated successfully with infliximab the functional significance of morphological changes in the dentitions of early mammals changing views of evolutionary factors at work on earliest mammals rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells rigid growth matrix a key to success of cardiac tissue engineering identification of alzheimer s disease and mild cognitive impairment using networks constructed based on multiple morphological brain features multi feature based brain network improves auto diagnosis of alzheimer s disease human epidermal langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory t cells double duty versatile immune cells play dual roles in human skin novel assay reveals a large inducible replication competent hiv reservoir in resting cd t cells toward an hiv cure team develops test to detect hidden virus leaf nutrients not specific leaf area are consistent indicators of elevated nutrient inputs leaves are nature s most sophisticated environment sensors targeted placental deletion of ogt recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction placental marker of prenatal stress linked to brain mitochondrial dysfunction discontinuation of smokeless tobacco and mortality risk after myocardial infarction quitting smokeless tobacco after heart attack may extend life expectancy ephb isolates a human marrow stromal cell subpopulation with enhanced ability to contribute to the resident intestinal cellular pool research supports promise of cell therapy for bowel disease vitamin d switches baf complexes to protect cells boosting the effects of vitamin d to tackle diabetes glutamate release by primary brain tumors induces epileptic activity research points to potential therapy for tumor associated epilepsy the spider tree of life phylogeny of araneae based on target gene analyses from an extensive taxon sampling a new web of life first full family tree of the world s spiders blood biomarkers for brain injury in concussed professional ice hockey players blood test identifies brain damage from concussion in ice hockey the role of ptsd depression and alcohol misuse symptom severity in linking deployment stressor exposure and post military work and family outcomes in male and female veterans deployment stress impacts well being through different mental health issues for female and male vets risk of exposure to air pollution among british children with and without intellectual disabilities study uncovers link between air pollution and intellectual disabilities in children association between the seven repeat allele of the dopamine receptor gene drd and spontaneous food intake in pre school children brain reward gene influences food choices in the first years of life mouse mammary stem cells express prognostic markers for triple negative breast cancer stem cell test could identify most aggressive breast cancers efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia a single arm open label phase study new medication shows promise as lipid lowering therapy for rare cholesterol disorder atypical cry acoustics in month old infants at risk for autism spectrum disorder researchers study cry acoustics to determine risk for autism arginine vasopressin in cerebrospinal fluid is a marker of sociality in nonhuman primates vasopressin a possible biomarker for social deficits in autism eighteen year trajectories of depressive symptoms in mothers with a lifetime eating disorder findings from the alspac cohort prior eating disorders linked to long term depression risk for mothers drug based modulation of endogenous stem cells promotes functional remyelination in vivo researchers discover new drugs to combat the root cause of multiple sclerosis emergency postexposure vaccination with vesicular stomatitis virus vectored ebola vaccine after needlestick researchers examine effect of experimental ebola vaccine after high risk exposure generation and acculturation status are associated with dietary intake and body weight in mexican american adolescents mexican american youth add pounds as they lose native eating habits a demographic approach to study effects of climate change in desert plants demographic miracle in the deserts some plants in arid regions benefit from climate change portrayal of tobacco use in prime time tv dramas trends and associations with adult cigarette consumption usa dwindling visibility of tobacco in prime time us tv linked to fall in smoking rates healthy diets and the subsequent prevalence of nuclear cataract in women healthy diet associated with lower risk of cataracts in women interventions to improve antibiotic prescribing practices for hospital inpatients support for health professionals reduces unnecessary use of antibiotics in hospitals in home virtual reality videogame telerehabilitation in adolescents with hemiplegic cerebral palsy virtual reality tele rehab improves hand function playing games for real recovery fetal and neonatal exposure to nicotine leads to augmented hepatic and circulating triglycerides in adult male offspring due to increased expression of fatty acid synthase fetal exposure to nicotine increases long term risk of obesity gene by sex interactions in mitochondrial functions and cardio metabolic traits the lypla gene impacts obesity in a sex specific manner delivering on antimicrobial resistance agenda not possible without improving fungal diagnostic capabilities better diagnosis of fungal infections key to reducing antibiotic resistance design flaws consequences of the coverage gap in food programs for children at kindergarten entry age limit for federal food assistance program impacts reading scores learning disruption of katp channel expression in skeletal muscle by targeted oligonucleotide delivery promotes activity linked thermogenesis reducing energy efficiency boosts calorie burning in muscle ancient human mitochondrial dna and radiocarbon analysis of archived quids from the mule spring rockshelter nevada usa ancient quids reveal clues about genetic ancestry of early great basin inhabitants place and cause of death in centenarians a population based observational study in england to new health services needed for rise in year olds a locus at q. confers resistance to tuberculosis in highly susceptible individuals hiv patients in africa with a specific genetic variant have much lower rate of tb sensitizing protective tumor microenvironments to antibody mediated therapy new weapon fights drug resistant tumors hiding in bone marrow microbiomes of the dust particles collected from the international space station and spacecraft assembly facilities high tech methods study bacteria on the international space station modeling the influence of genetic and environmental variation on the expression of plant life cycles across landscapes plant s life cycle how stages of seeds interact with each other origins and spread of fluted point technology in the canadian ice free corridor and eastern beringia spear point study offers new explanation of how early humans settled north america lateral impacts correlate with falx cerebri displacement and corpus callosum trauma in sports related concussions role of a deep brain structure in concussion modulation of hcv replication after combination antiretroviral therapy in hcv hiv co infected patients combination antiretroviral therapy helps treat hcv in patients co infected with hiv vaginal progesterone decreases preterm birth and neonatal morbidity and mortality in women with a twin gestation and a short cervix an updated meta analysis of individual patient data vaginal progesterone reduces the rate of preterm birth tissue specific mutation accumulation in human adult stem cells during life first evidence direct from human stem cells provides new insight into cancer lifestyle vs bad luck debate the environmental impact of fertilizer embodied in a wheat to bread supply chain how to reduce the environmental impact of a loaf of bread ? the primary glucose lowering effect of metformin resides in the gut not the circulation. results from short term pharmacokinetic and week dose ranging studies diabetes drug metformin s primary effect is in the gut not the bloodstream pediatric hospital discharges to home health and postacute facility care home health care post acute care in a facility infrequent for hospitalized kids does watching sex on television predict teen pregnancy ? findings from a national longitudinal survey of youth teen pregnancy linked to viewing of sexual content on tv land cover change in northern botswana the influence of climate fire and elephants on semi arid savanna woodlands extensive loss of trees in african savannas blame human started fires not elephants a mixed modality approach towards xi reactivation for rett syndrome and other x linked disorders x chromosome reactivation could treat rett syndrome other x linked disorders cranial osteopathy for children with cerebral palsy a randomised controlled trial osteopathy of no benefit to children with cerebral palsy research finds alcohol advertising on facebook and the desire to drink among young adults alcohol ads with pro drinking comments on facebook boost desire to drink study finds carbon nanotubes might improve neuronal performance by favouring electrical shortcuts faulty brain wiring may be bypassed with carbon nanotubes major physical health conditions and risk of suicide burden of physical health conditions linked to increased risk of suicide mortality attributable to low levels of education in the united states deaths attributed to low levels of education lack of education as deadly as smoking discovering good practice for art therapy with children who have autism spectrum disorder the results of a small scale survey art therapy best practices for children with autism jarid coordinates nanog expression and pcp wnt signaling required for efficient esc differentiation and early embryo development new conductor takes centre stage in the early embryo thermalization near integrability in a dipolar quantum newton s cradle toy inspired experiment on behavior of quantum systems establishing a mental lexicon with cochlear implants an erp study with young children deaf children with cochlear implant learn words faster than hearing children incidence and trends of sepsis in us hospitals using clinical vs claims data measuring sepsis incidence and trends in us hospitals using clinical data inflammatory markers are associated with risk of colorectal cancer and chemopreventive response to anti inflammatory drugs aspirin s ability to protect against colorectal cancer may depend on inflammatory pathways astrocyte derived endothelin inhibits remyelination through notch activation protein to repair damaged brain tissue in ms identified tet oxidizes thymine to hydroxymethyluracil in mouse embryonic stem cell dna stem cell research a new genetic switching element temporal dynamics of neurogenomic plasticity in response to social interactions in male threespined sticklebacks brief interactions spur lasting waves of gene activity in the brain biohistorical materials and contemporary privacy concerns the forensic case of king albert i blood of king albert i identified after years greater hippocampal volume is associated with ptsd treatment response size of brain region is associated with response to ptsd treatment direct evidence of hierarchical assembly at low masses from isolated dwarf galaxy groups astronomers find seven dwarf galaxy groups the building blocks of massive galaxies domain morphology boundaries and topological defects in biophotonic gyroid nanostructures of butterfly wing scales x ray snapshot of butterfly wings reveals underlying physics of color targeting sirt controls gvhd by inhibiting t cell allo response and promoting treg stability in mice new therapeutic target for graft vs host disease could make bone marrow transplant safer t regulatory cells support plasma cell populations in the bone marrow t cells support long lived antibody producing cells team finds a bacterial proteorhodopsin proton pump in marine eukaryotes single cell marine predator s unique survival mechanisms revealed european national government approaches to older people s transport system needs governments need to do more to support older people s transport needs study suggests frontal deficits differentiate progressive supranuclear palsy from parkinson s disease similar but different new discovery for degenerative diseases avelumab plus axitinib versus sunitinib for advanced renal cell carcinoma drug combination may become new standard treatment for advanced kidney cancer a healthy gastrointestinal microbiome is dependent on dietary diversity reduction in dietary diversity impacts richness of human gut microbiota differences in the vulnerability of waterbird species to botulism outbreaks in mediterranean wetlands an assessment of ecological and physiological factors botulism in waterbirds mortality rates and new insights into how it spreads a genetic chronology for the indian subcontinent points to heavily sex biased dispersals archaeogeneticist pinpoints indian population origins using today s populace integrating tobacco cessation into mental health care for posttraumatic stress disorder a randomized controlled trial including smoking cessation program with treatment for ptsd shows higher rate of quitting country and manufacturer level attribution of air quality impacts due to excess nox emissions from diesel passenger vehicles in europe emissions from most diesel cars in europe greatly exceed laboratory testing levels using drugs to discriminate adverse selection in the insurance marketplace health insurers using drug coverage to discriminate experts say long range movement of humpback whales and their overlap with anthropogenic activity in the south atlantic ocean whales and human related activities overlap in african waters extended survival and prognostic factors for patients with alk rearranged non small cell lung cancer and brain metastasis rare mutation may extend survival in lung cancer patients with brain metastases detecting species at low densities a new theoretical framework and an empirical test on an invasive zooplankton forget needle in a haystack try finding an invasive species in a lake skin infection generates non migratory memory cd trm cells providing global skin immunity skin infection sheds light on immune cells living in our skin activation of muscular trkb by its small molecular agonist dihydroxyflavone sex dependently regulates energy metabolism in diet induced obese mice molecule found in tree leaves helps female mice combat weight gain males unaffected safety of quadrivalent human papillomavirus vaccine administered routinely to females study affirms safety of hpv vaccine for adolescents and young women in routine clinical care network analyses identify liver specific targets for treating liver diseases new targets for drugs to treat fatty liver disease and liver cancer frankincense oil derived from boswellia carteri induces tumor cell specific cytotoxicity frankincense oil a wise man s remedy for bladder cancer effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers a randomised controlled trial tomato pill improves function of blood vessels in patients with cardiovascular disease frequency synchronization of blue whale calls near pioneer seamount blue whales align the pitch of their songs with extreme accuracy study finds the imprint of cosmic reionization on the luminosity function of galaxies astronomers identify some of the oldest galaxies in the universe haploinsufficiency of the notch receptor as a cause of adams oliver syndrome with variable cardiac anomalies one gene closer to helping sufferers of rare genetic disorder mental health among parents of children with critical congenital heart defects a systematic review parents of children with serious heart defects may be at risk of ptsd structural and functional substitution of deleted primary sensory neurons by new growth from intrinsic spinal cord nerve cells an alternative concept in reconstruction of spinal cord circuits new surgical strategy offers hope for repairing spinal injuries pelagic subsidies underpin fish productivity on a degraded coral reef ocean currents bring good news for reef fish regional practice patterns and outcomes of surgery for acute type a aortic dissection new surgical techniques help save patients from life threatening heart condition dental caries in american indian toddlers after a community based beverage intervention preventing tooth decay in the youngest american indians characterizing mutational signatures in human cancer cell lines reveals episodic apobec mutagenesis major mutation pattern in cancer occurs in bursts loss of il receptor alters the endurance fatigability and metabolic characteristics of mouse fast skeletal muscles endurance gene for olympic level athletes genetic basis for muscle endurance discovered in animal study can ratings have indirect effects ? evidence from the organizational response to peers environmental ratings taming polluting companies ratings have spillover effects leading to reduced toxic emissions strategy based reasoning training modulates cortical thickness and resting state functional connectivity in adults with chronic traumatic brain injury strategic brain training positively affects neural connectivity for individuals with tbi round trip across the sahara afrotropical painted lady butterflies recolonize the mediterranean in early spring painted lady s roundtrip migratory flight is the longest recorded in butterflies truncating variants in naa are associated with variable levels of intellectual disability autism spectrum disorder and congenital anomalies newly identified gene mutation results in intellectual disability and developmental delay sizing ocean giants patterns of intraspecific size variation in marine megafauna sizing up giants under the sea biologists correct inaccuracies for marine species identification of neurodegenerative factors using translatome regulatory network analysis new research sheds light on the molecular origins of parkinson s disease common variants in acyp influence susceptibility to cisplatin induced hearing loss inherited gene variations tied to treatment related hearing loss in cancer patients comparative use of a caribbean mesophotic coral ecosystem and association with fish spawning aggregations by three species of shark comparative analysis reveals use patterns of deeper caribbean coral reefs by shark species serpins promote cancer cell survival and vascular co option in brain metastasis mechanisms cancer cells use to establish metastatic brain tumors revealed by research microwave assisted fabrication of titanium implants with controlled surface topography for rapid bone healing new biomedical implants heal bones faster focus on personalized medicine characteristics of severe bordetella pertussis infection among infants days of age admitted to pediatric intensive care units southern california september june study identifies infants at highest risk of death from pertussis early and repeated white blood cell counts are a critical tool major earthquakes occur regularly on an isolated plate boundary fault new evidence for regular magnitude earthquakes study of new zealand fault shows reproductive control by others means perpetrators and effects one in four women at sexual health clinics reports coercion over their reproductive lives iron fortified vs low iron infant formula developmental outcome at years routine iron fortification of infant formula linked to poorer development tunable near infrared and visible light transmittance in nanocrystal in glass composites raising the iq of smart windows embedded nanocrystals provide selective control over visible light and heat producing near infrared light a late middle pleistocene denisovan mandible from the tibetan plateau first hominins on the tibetan plateau were denisovans using alternatives to face to face consultations a survey of prevalence and attitudes in general practice survey reveals few gps use alternatives to face to face consultations histone h k h k demethylase phf regulates zebrafish brain and craniofacial development new epigenetic player implicated in mental retardation and facial birth defects experimental climate change weakens the insurance effect of biodiversity loss of species makes nature more sensitive to climate change study finds stepping toward self powered papertronics integrating biobatteries into a single sheet of paper scientists build bacteria powered battery on single sheet of paper incident opioid drug use among older adults with chronic obstructive pulmonary disease a population based cohort study high opioid use in older people with copd raises safety concerns stat is required for proliferation and maintenance of multipotency in glioblastoma stem cells stat gene regulates cancer stem cells in brain cancer higher whole grain intake is associated with lower risk of type diabetes among middle aged men and women the danish diet cancer and health cohort whole grains one of the most important food groups for preventing type diabetes enhancing disease surveillance with novel data streams challenges and opportunities using patients trail of digital crumbs for public health surveillance crystallization of silicon dioxide and compositional evolution of the earth s core quartz crystals at earth s core power its magnetic field short term auditory effects of listening to an mp player portable media players associated with short term hearing effects treatment of metastatic melanoma with autologous cd t cells against ny eso patient s own infection fighting t cells put late stage melanoma into long term remission aminobutyric a receptor gabaar regulates aquaporin expression in the subependymal zone relevance to neural precursors and water exchange glimpse into the regulation of water exchange in the brain the art and craft of phonomicrosurgery in grammy award winning elite performers comprehensive review analyzes vocal cord restoration in grammy award winning singers climate change disables coral bleaching protection on the great barrier reef great barrier reef risks losing tolerance to bleaching events copper containing intra uterine devices versus depot progestogens for contraception iuds reduce pregnancy rates compared to hormonal contraceptives review finds interleukin induces type cytokine production in a steroid resistant interleukin rb myeloid population that exacerbates asthmatic pathology new type of cell with a key role in treatment resistant asthma synthetic essentiality of chromatin remodelling factor chd in pten deficient cancer researchers identify synthetic essentiality as novel approach for locating cancer therapy targets stress induced recruitment of bone marrow derived monocytes to the brain promotes anxiety like behavior mood is influenced by immune cells called to the brain in response to stress unlocking the puzzling biology of the black p rigord truffletuber melanosporum scientists unearth secrets of p rigord truffles the culinary black diamond natural killer cell mediated inflammation resolution is disabled in severe asthma breath of fresh air for severe asthma research modeling of regional climate change effects on ground level ozone and childhood asthma future climate change may increase asthma attacks in children mri magnetic field stimulates rotational sensors of the brain researchers pinpoint the cause of mri vertigo machine s magnetic field pushes fluid in the inner ear s balance organ social isolation shortens telomeres in african grey parrots psittacus erithacus erithacus the long and the short of telomeres loneliness impacts dna repair parrot study shows uncorrected hyperopia and preschool early literacy results of the vision in preschoolers hyperopia in preschoolers vip hip study uncorrected farsightedness linked to literacy deficits in preschoolers disparities in rooftop photovoltaics deployment in the united states by race and ethnicity racial inequality in the deployment of rooftop solar energy in the united states study finds genetically engineered bt corn and range expansion of the western bean cutworm lepidoptera noctuidae in the united states a response to greenpeace germany scientists refute claim that genetically modified corn caused new insect pest effectiveness of herpes zoster vaccine in patients years and older with end stage renal disease shingles vaccine helps protect older patients with end stage renal disease systematic interaction network filtering identifies crmp as a novel suppressor of huntingtin misfolding and neurotoxicity novel regulator inhibits toxic protein aggregates in huntington s disease dehydration induced expression of a kda dehydrin in polypodium polypodioides polypodiaceae may enable large reversible deformation of cell walls bringing dehydrated plants back to life possible key to desiccation tolerant plants the human hippocampus contributes to both the recollection and familiarity components of recognition memory brain s hippocampus is essential structure for all aspects of recognition memory researchers find global warming hiatus contributed to the increased occurrence of intense tropical cyclones in the coastal regions along east asia la ni a like ocean cooling patterns intensify northwestern pacific tropical cyclones function and structure of leaves contributing to increasing water storage with height in the tallest cryptomeria japonica trees of japan treetop leaves of tall trees store extra water epigenetic changes in histone acetylation underpin resistance to the topoisomerase i inhibitor irinotecan new discovery in understanding chemotherapy resistance could prevent cancer cells fighting back national randomized controlled trial of virtual house calls for parkinson disease telemedicine as effective as in person care for parkinson s disease effects of initiating palliative care consultation in the emergency department on inpatient length of stay quick palliative care consultations in emerg results in significantly shorter hospital stays restoring oxidant signaling suppresses proarthritogenic t cell effector functions in rheumatoid arthritis prooxidants may fix metabolic defect in arthritis driving t cells national record linkage study of mortality for a large cohort of opioid users ascertained by drug treatment or criminal justice sources in england age concern in largest ever study of heroin user deaths the effect of prenatal sex hormones on the development of verbal aggression relative length of adults fingers indicator of verbal aggression prenatal exposure to testosterone linked rnai targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction potential new therapy could reduce dangerous post heart attack inflammation the international health regulations years on the governing framework for global health security law experts propose revisions for international health regulations pedagogical applications of cognitive research on musical improvisation new approach to teaching music improvisation enhances creativity a proof of principle prospective randomized controlled trial demonstrating improved outcomes in scheduled unsedated colonoscopy by the water method studies show improved patient tolerance for unsedated colonoscopy using novel water method effect of neuromuscular warm up on injuries in female soccer and basketball athletes in urban public high schools cluster randomized controlled trial neuromuscular warm up associated with reduced lower extremity injuries in adolescent female athletes exploring fingerprints of the extreme thermoacidophile metallosphaera sedula grown on synthetic martian regolith materials as the sole energy sources looking for microbe fingerprints on simulated martian rocks the stem cell concept is it holding us back ? is stem cell concept holding back biology ? a novel fbxo frameshift mutation in a child with developmental delay dysmorphic features and intractable epilepsy a second gene that may contribute to the q q deletion phenotype mutated gene is likely cause of year old girl s severe disorder culturable mold in indoor air and its association with moisture related problems and asthma and allergy among swedish children no link between mold growth and development of asthma and allergy scandinavian study finds proteomic profiling of cranial superior cervical ganglia reveals beta amyloid ubiquitin proteasome system perturbations in an equine multiple system neuropathy horse sickness shares signs of human brain disorders study finds plasma hydroxyvitamin d and bladder cancer risk according to tumor stage and fgfr status a mechanism based epidemiological study high levels of vitamin d in plasma protects against bladder cancer elevated brain cannabinoid cb receptor availability in post traumatic stress disorder a positron emission tomography study brain imaging study links cannabinoid receptors to post traumatic stress disorder first pharmaceutical treatment for ptsd within reach research investment implications of shifts in the global geography of wheat stripe rust lack of attention has made stripe rust a threat to the world s wheat report shows low temperature crystallization of granites and the implications for crustal magmatism yosemite granite tells a different story story about earth s geologic history the aging road warrior national trend toward older riders impacts outcome after motorcycle injury aging motorcyclists hit the road but at greater risk of injury death study finds energy dissipation in mammalian collagen fibrils cyclic strain induced damping toughening and strengthening collagen nanofibrils in mammalian tissues get stronger with exercise paternal obesity is associated with igf hypomethylation in newborns results from a newborn epigenetics study nest cohort obesity in dads may be associated with offspring s increased risk of disease jedek a newly discovered aslian variety of malaysia language previously unknown to linguists discovered in southeast asia synchronicity of antarctic temperatures and local solar insolation on orbital time scales new interpretation of antarctic ice cores prevailing theory on climate history expanded drought induced starvation of aardvarks in the kalahari an indirect effect of climate change aardvarks fate points to worrying consequences for wildlife due to climate change ultrasound triggered disruption and self healing of reversibly cross linked hydrogels for drug delivery and enhanced chemotherapy delivering chemo drugs on cue ultrasound and self healing hydrogels deliver drugs noninvasively at right place right time development of gender typicality and felt pressure in european french and north african french adolescents ethnic and gender differences in youths developing gender identity r loop formation at snord mediates topotecan inhibition of ube a antisense and allele specific chromatin decondensation how a cancer drug unties knots in the chromosome that causes angelman and prader willi syndromes gfap mutations in astrocytes impair oligodendrocyte progenitor proliferation and myelination in an hipsc model of alexander disease new stem cell model can be used to test treatments for a rare nervous system disorder antibiotic induced perturbations in gut microbial diversity influences neuro inflammation and amyloidosis in a murine model of alzheimer s disease antibiotics weaken alzheimer s disease progression through changes in the gut microbiome aberrant functioning of the theory of mind network in children and adolescents with autism social stress brain circuitry fails to connect in children with autism intact but empty forests ? patterns of hunting induced mammal defaunation in the tropics hunting responsible for mammal declines in half of intact tropical forests large scale controls of methanogenesis inferred from methane and gravity spaceborne data higher temperatures can worsen climate change methane measurements from space reveal pac an evolutionarily conserved membrane protein is a proton activated chloride channel stroke cancer and heart disease key acid activated protein channel assessing risks of invasion through gamete performance farm atlantic salmon sperm and eggs show equivalence in function fertility compatibility and competitiveness to wild atlantic salmon farm salmon pose clear reproductive threat to wild gene pools researchers say insect metabolic and population growth rates predict increasing crop losses in a warming climate climate change projected to boost insect activity and crop loss researchers say reflex estrogen receptor progesterone receptor human epidermal growth factor receptor er pr her analysis of breast cancers in needle core biopsy specimens dramatically increases health care costs smarter ordering of breast biomarker tests could save millions in health care dollars nanosecond laser therapy reverses pathologic and molecular changes in age related macular degeneration without retinal damage laser treatment reverses effects of early age related macular degeneration future climate forcing potentially without precedent in the last million years future carbon dioxide climate warming potentially unprecedented in million years developing a continuous bioprocessing approach to stromal cell manufacture the future of cell culture a new continuous bioprocess developed diagnosis of elder abuse in u.s. emergency departments elder abuse under identified in u.s. emergency departments the fertilizing role of african dust in the amazon rainforest a first multiyear assessment based on calipso lidar observations massive amounts of saharan dust fertilize the amazon rainforest counting growth factors in single cells with infrared quantum dots to measure discrete stimulation distributions researchers are first to count growth factors in single cells novel vascular endothelial growth factor gene delivery system manipulated mesenchymal stem cells repair infarcted myocardium an economical effective and biocompatible gene therapy strategy promotes cardiac repair internal carotid artery dissection after a roller coaster ride in a year old. case report and review of the literature roller coaster rides trigger stroke in young boy the chronic ischaemic cardiovascular disease esc pilot registry results of the six month follow up nearly percent of chronic ischemic heart disease patients dead or hospitalized in months california s nurse to patient ratio law and occupational injury higher nurse to patient standard improves staff safety study shows understanding school effects on students willingness to report peer weapon carrying students reporting of weapons at school factors that influence decision to tell high efficiency colloidal quantum dot infrared light emitting diodes via engineering at the supra nanocrystalline level colloidal quantum dots make leds shine bright in the infrared early life factors for myopia in the british twins early development study summer birth and computer games linked to heightened short sight risk in childhood a new pleiotropic effect of statins in elderly modulation of telomerase activity statins may slow human aging by protecting against telomere shortening a feature of senescent cells pharmacist participation in acute ischemic stroke decreases door to needle time to recombinant tissue plasminogen activator having a pharmacist at stroke patient s bedside speeds administration of critical drug low frequency electro acupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome for women with polycystic ovarian syndrome acupuncture and exercise may bring relief reduce risks premature deaths of nursing home residents an epidemiological analysis increase in premature deaths in australian nursing homes field investigations for evaluating green infrastructure effects on air quality in open road conditions plant hedges to combat near road pollution exposure environmental drivers of demographic variation across the global geographical range of plant species large scale environmental variation affects reproduction and survival of plants anti diabetic drug metformin suppresses endotoxin induced uveitis in rats. diabetes drug could treat leading cause of blindness metformin blocks uveitis in rats predicted distribution of the glass sponge vazella pourtalesi on the scotian shelf and its persistence in the face of climatic variability persistence of glass sponge in face of climatic variability the angelina jolie effect how high celebrity profile can have a major impact on provision of cancer related services double mastectomy angelina effect in referrals for genetic counseling and breast cancer testing involvement of human ribosomal proteins in nucleolar structure and p dependent nucleolar stress aspects of the regulation of the anti tumor protein p formation of neurodegenerative aggresome and death inducing signaling complex in maternal diabetes induced neural tube defects researchers identify link between birth defect neurodegenerative diseases diverse types of genetic variation converge on functional gene networks involved in schizophrenia schizophrenia genetic networks identified connection to autism found liver x receptors contribute to the protective immune response against mycobacterium tuberculosis in mice lxr proteins new target in the war on tuberculosis ? more daytime sleeping predicts less functional recovery among older people undergoing inpatient post acute rehabilitation more daytime sleeping predicts less recovery during rehabilitation for older adults nptx and cognitive dysfunction in alzheimer s disease low levels of memory protein linked to cognitive decline in alzheimer s disease orientation behaviour of leatherback sea turtles within the north atlantic subtropical gyre tracking sea turtles across hundreds of miles of open ocean association of occult metastases in sentinel lymph nodes and bone marrow with survival among women with early stage invasive breast cancer detecting occult metastases in lymph nodes not associated with overall survival in breast cancer hormonal testing and pharmacologic treatment of erectile dysfunction a clinical practice guideline from the american college of physicians erectile dysfunction treatment with oral medications demonstrates significant improvements in sexual intercourse and erectile function hormone replacement therapy and mid term implant survival following knee or hip arthroplasty for osteoarthritis a population based cohort study hormone replacement therapy cuts risk of repeat knee hip replacement surgery by percent incidence of hypertension related emergency department visits in the united states to hypertension related visits to emergency rooms on rise in us suicide attempt as a risk factor for completed suicide even more lethal than we knew suicide attempt a stronger predictor of completed suicide than previously thought small airway on a chip enables analysis of human lung inflammation and drug responses in vitro modeling copd asthma in a human small airway on a chip bottlenose dolphins as indicators of persistent organic pollutants in the western north atlantic ocean and northern gulf of mexico marine lab research tracks pollutants in dolphins and beluga whales rapid adaptive evolution of colour vision in the threespine stickleback radiation stickleback fish adapt their vision in the blink of an eye demystifying jadeite an underwater maya discovery at ek way nal belize high quality jadeite tool discovered in underwater ancient salt works in belize analgesic use and the risk of hearing loss in women popular pain relieving medicines linked to hearing loss in women dual smad signaling inhibition enables long term expansion of diverse epithelial basal cells new procedure allows long term culturing of adult stem cells directed differentiation of human pluripotent stem cells to microglia robust high throughput protocol for deriving microglia from human stem cells reported pharmacogenetic predictors of methylphenidate dose response in attention deficit hyperactivity disorder children with certain dopamine system gene variants respond better to adhd drug a regional initiative to reduce skin infections amongst aboriginal children living in remote communities of the northern territory australia reduced skin infections in northern australian aboriginal children decadal scale variation in diet forecasts persistently poor breeding under ocean warming in a tropical seabird a gal pagos seabird s population expected to shrink with ocean warming cancer disparities in rural appalachia incidence early detection and survivorship the unseen cancer crisis alarming disparities found across appalachia contrasting roles of histone lysine demethylases in acute lymphoblastic leukaemia master regulator gene long tied to autism disorders can stimulate other genes involved in early brain development evaluating the implementation of health checks for adults with intellectual and developmental disabilities in primary care the importance of organizational context new toolkit can improve primary healthcare for people with developmental disabilities multiinstrument observations of a geomagnetic storm and its effects on the arctic ionosphere a case study of the february storm eruptions on the sun trigger surprising phenomenon near earth targeting pim kinase with pd inhibition improves immunotherapeutic anti tumor t cell response triple combination cancer immunotherapy improves outcomes in preclinical melanoma model the genesis and source of the h n influenza viruses causing human infections in china genesis and evolution of h n influenza virus small molecules co targeting cki and the transcriptional kinases cdk control aml in preclinical models acute leukemia drug trials show percent cure rate in lab mice the density compression ratio of shock fronts associated with coronal mass ejections three nasa satellites recreate solar eruption in d historical photographs revisited a case study for dating and characterizing recent loss of coral cover on the inshore great barrier reef study accurately dates coral loss at great barrier reef effects of botulinum toxin on improving facial surgical scars botox improves appearance of facial scars in reconstructive surgery assessing demographic effects of dams on diadromous fish a case study for atlantic salmon in the penobscot river maine new model predicts fish population response to dams other ecological factors contribution of sea ice loss to arctic amplification is regulated by pacific ocean decadal variability influence of sea ice loss on arctic warming is shaped by temperatures in the pacific ocean dexamethasone potentiates in vitro blood brain barrier recovery after primary blast injury by glucocorticoid receptor mediated upregulation of zo tight junction protein steroids rapidly restore blood brain barrier function after blast the continuing rise of gun violence in pg movies to gun violence in pg movies continues to climb past r rated films clindamycin versus trimethoprim sulfamethoxazole for uncomplicated skin infections two commonly used antibiotics have similar cure rates for uncomplicated skin infections metabolic imaging allows early prediction of response to vandetanib pet scans may allow early prediction of response to targeted therapy of thyroid cancer floor management systems in an organic apple orchard affect fruit quality and storage life sandwich system found effective in organic apple orchards probing magnetism in d materials at the nanoscale with single spin microscopy unprecedented insight into two dimensional magnets using diamond quantum sensors lypd promotes the segregation of flagellated microbiota and colonic epithelia revealed mechanism for inhibiting bacterial invasion of colonic epithelia palaeoshellomics reveals the use of freshwater mother of pearl in prehistory freshwater mussel shells were material of choice for prehistoric craftsmen a review of global trends in cites live wildlife confiscations gaps in data place thousands of illegally traded wild animals at risk say researchers childhood iq and adult mental disorders a test of the cognitive reserve hypothesis lower childhood iq associated with higher risk of adult mental disorders acute alcohol intoxication and suicide among united states ethnic racial groups findings from the national violent death reporting system native americans at greater risk of suicide after alcohol intoxication the transcription factor ifn regulatory factor controls experimental colitis in mice via t cell derived il the protein irf takes control of inflammation in the gut expectations for recovery important in the prognosis of whiplash injuries patients expectation of getting better is crucial in recovery from whiplash targeting the mtf mdm axis sensitizes refractory acute myeloid leukemia to chemotherapy new drug combination destroys chemo resistant blood cancer the effectiveness of high dose zinc acetate lozenges on various common cold symptoms a meta analysis high dose zinc acetate lozenges may help shorten symptoms associated with the common cold use of prescription pain medications among medical cannabis patients comparisons of pain levels functioning and patterns of alcohol and other drug use substance abuse risk not greater in those using medical marijuana with prescribed opioids evidence of long term nao influence on east central europe winter precipitation from a guano derived n record bat feces a reliable source of climate change frequency reasons for and perceptions of lubricant use among a nationally representative sample of self identified gay and bisexual men in the united states most gay bisexual men in united states have used lubricants during sexual activity modified mediterranean diet score and cardiovascular risk in a north american working population mediterranean diet linked with lower risk of heart disease among young u.s. workers short term versus long term dual antiplatelet therapy after implantation of drug eluting stent in patients with or without diabetes systematic review and meta analysis of individual participant data from randomised trials the war on drugs causes massive human rights violations a chromosome based draft sequence of the hexaploid bread wheat triticum aestivum genome chromosome based draft of the wheat genome completed effects of weight loss induced by gastric bypass surgery on hdl remodeling in obese women significant weight loss from surgery decreases risk for cardiovascular disease in women demographic monitoring of wild muriqui populations criteria for defining priority areas and monitoring intensity monkey study shows a path to monitoring endangered species examining the role of the pediatric emergency department in reducing unintended adolescent pregnancy teen girls at higher risk ok with emergency department offering pregnancy prevention info sharp increase in central oklahoma seismicity since induced by massive wastewater injection oklahoma earthquakes induced by wastewater injection by disposal wells study finds quantifying the proportion of severe asthma exacerbations attributable to inhaled corticosteroid nonadherence improved medication use could reduce severe asthma attacks glucagon like peptide receptor activation in the ventral tegmental area attenuates cocaine seeking in rats a potential new weapon in the addiction battle fda approved diabetes and obesity drugs nanostructured glycan architecture is important in the inhibition of influenza a virus infection nano decoy lures human influenza a virus to its doom beyond the periphery child and adult understanding of world map continuity we have difficulty understanding the world map s edge feasibility of using a community supported agriculture program to improve fruit and vegetable inventories and consumption in an underresourced urban community ease of access improves fruit and vegetable consumption role of microrna processing in adipose tissue in stress defense and longevity molecular process in fat cells that influences stress and longevity identified perinatal exposure to traffic related air pollution and atopy at year of age in a multi center canadian birth cohort study exposure to air pollution in the first year of life increases risk for allergies pregnancy induced gene expression changes in vivo among women with rheumatoid arthritis a pilot study possible link between type i interferons natural improvement of rheumatoid arthritis during pregnancy pilot study finds sharp wave ripples orchestrate the induction of synaptic plasticity during reactivation of place cell firing patterns in the hippocampus best to sleep on it brain activity patterns during sleep consolidate memory maternal consumption of artificially sweetened beverages during pregnancy and offspring growth through years of age a prospective cohort study drinking diet beverages during pregnancy linked to child obesity study suggests thalamic spindles promote memory formation during sleep through triple phase locking of cortical thalamic and hippocampal rhythms controlling memory by triggering specific brain waves during sleep scalable fabrication of stable high efficiency perovskite solar cells and modules utilizing room temperature sputtered sno electron transport layer scientists boost stability of low cost large area solar modules genome wide assessment of world wide chicken snp genetic diversity indicates significant absence of rare alleles in commercial breeds commercial poultry lack genetic diversity are vulnerable to avian flu and other threats single vs multiple fraction radiotherapy for bone metastases from prostate cancer when more medicine isn t always better high costs of unnecessary radiation for terminal cancer patients the earliest human occupation of the high altitude tibetan plateau thousand to thousand years ago new archaeological site revises human habitation timeline on tibetan plateau mutations in cockayne syndrome associated genes csa and csb predispose to cisplatin induced hearing loss in mice cisplatin may cause more permanent hearing loss in people with cockayne syndrome association of mental disorders with subsequent chronic physical conditions mental disorders associated with subsequent chronic physical conditions maternal auxin supply contributes to early embryo patterning in arabidopsis plant mothers talk to their embryos via the hormone auxin noninvasive tracking of gene transcript and neuroprotection after gene therapy eye drops deliver gene therapy for brain disorders unnecessary frills communality as a nice but expendable trait in leaders feminine leadership traits nice but expendable frills ? beyond immune density critical role of spatial heterogeneity in estrogen receptor negative breast cancer new breast cancer test links immune hotspots to better survival prevalence of genital human papillomavirus infection and human papillomavirus vaccination rates among us adult men national health and nutrition examination survey nhanes hpv prevalence rates among us men vaccination coverage cell cycle perturbation induced by gemcitabine in human tumor cells in cell culture xenografts and bladder cancer patients implications for clinical trial designs combining gemcitabine with a chk inhibitor comparing cancer drug effectiveness from cells to mice to man temporal trends and developmental patterns of plasma polybrominated diphenyl ether concentrations over a year period between and childhood exposure to flame retardant chemicals declines following phase out herbicide usage for invasive non native plant management in wildland areas of north america research reveals widespread herbicide use on north american wildlands clostridium difficile outbreak strain bi is highly endemic in chicago area hospitals outbreak c. difficile strain common in chicago hospitals investigation finds yfibnr mediates cyclic di gmp dependent small colony variant formation and persistence in pseudomonas aeruginosa molecular basis for pseudomonas aeruginosa persistent infections in cf patients serum hydroxyvitamin d concentration and risk for major clinical disease events in a community based population of older adults vitamin d blood level for reducing major medical risks in older adults identified study suggests four new species of trigonopterus fauvel from the island of new britain coleoptera curculionidae new curiously scaled beetle species from new britain named after star wars chewbacca positive attitude toward math supports early academic success behavioral evidence and neurocognitive mechanisms positive attitude toward math predicts math achievement in kids a bony crested jurassic dinosaur with evidence of iridescent plumage highlights complexity in early paravian evolution rainbow dinosaur had iridescent feathers like a hummingbird social regulation of insulin signaling and the evolution of eusociality in ants ant study sheds light on the evolution of workers and queens efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib grid an international multicentre randomised placebo controlled phase trial new drug overcomes resistance in patients with rare sarcoma study suggests a novel environmental dna approach to quantify the cryptic invasion of non native genotypes invasion of non native species exposed by environmental dna viscoelasticity of tau proteins leads to strain rate dependent breaking of microtubules during axonal stretch injury predictions from a mathematical model key breaking point involved in traumatic brain injury modeled by researchers rapid seeding of the viral reservoir prior to siv viraemia in rhesus monkeys strikingly early seeding of hiv viral reservoir shown in study use of emergency department imaging in patients with minor trauma surge in use of cts in patients with minor injuries study shows extreme oceanographic forcing and coastal response due to the el ni o beach bashing last year s el ni o resulted in unprecedented erosion of pacific coastline recent trends in childhood attention deficit hyperactivity disorder childhood diagnosis of adhd increased dramatically over year period estimating causal effects of alcohol access and use on a broad set of risky behaviors regression discontinuity evidence what are the effects of alcohol access on risky behaviors in young adults ? nintendo wii remote controllers for head posture measurement accuracy validity and reliability of infrared optical head tracker nintendo wii game controllers help diagnose eye disorder hdac regulates a stress response pathway in melanoma to mediate escape from braf inhibitor therapy mechanism of resistance to braf inhibitors in melanoma identified a ph independent dna nanodevice for quantifying chloride transport in organelles of living cells dna devices perform bio analytical chemistry inside live cells individual and population level resource selection patterns of mountain lions preying on mule deer along an urban wildland gradient los angeles mountain lions hunt closer to human settlements than expected the short chain fatty acid propionate increases glucagon and fabp production impairing insulin action in mice and humans could a popular food ingredient raise the risk for diabetes and obesity ? dynamics of microscopic objects in optical tweezers experimental determination of underdamped regime and numerical simulation using multiscale analysis mass important at nano scale matters in calculations and measurements earlier initiation of art and further decline in mother to child hiv transmission rates mother to child hiv transmission at record low in the uk benzodiazepine use and risk of alzheimer s disease case control study long term use of pills for anxiety and sleep problems may be linked to alzheimer s huperzine a provides robust and sustained protection against induced seizures in scn a mutant mice huperzine a provides seizure protection in genetic epilepsy models utilization of the high spatial frequency component in adaptive beam shaping by using a virtual diagonal phase grating quality of laser beam shaping can be enhanced at no extra cost cognitive improving effects by highbush blueberry vaccinium crymbosum l. vinegar on scopolamine induced amnesia mice model blueberry vinegar improves memory in mice with amnesia porous aromatic framework modified electrospun fiber membrane as a highly efficient and reusable adsorbent for pharmaceuticals and personal care products removal soaking up pharmaceuticals and personal care products from water pregnancy outcome following maternal exposure to pregabalin may call for concern drug used for pain anxiety may be linked to birth defects degrees of population level susceptibility of australian terrestrial non volant mammal species to predation by the introduced red fox vulpes vulpes and feral cat felis catus australian mammals at greatest risk from cats and foxes s a is a novel therapeutic target for anaplastic thyroid carcinoma molecule that provides cellular energy found key to aggressive thyroid cancer prediction of atypical ductal hyperplasia upgrades through a machine learning approach to reduce unnecessary surgical excisions new machine learning method could spare some women from unnecessary breast surgery policy implications of aging in the nih funded workforce how the graying biomedical workforce affects scientific funding in the us the presence of non native species is not associated with native fish sensitivity to water pollution in greatly hydrologically altered rivers non native species do not make native fish more vulnerable to pollution in mediterranean rivers crispr mediated tcr replacement generates superior anticancer transgenic t cells improved method of engineering t cells to attack cancer annual report to the nation on the status of cancer featuring the burden and trends in human papillomavirus hpv associated cancers and hpv vaccination coverage levels hpv associated cancer incidence rates point to needed efforts to increase hpv vaccination coverage metabolic regulation of dermal fibroblasts contributes to skin extracellular matrix homeostasis and fibrosis new approach may curb treatment related skin fibrosis in cancer patients convective forces increase cxcr dependent glioblastoma cell invasion in gl murine model new drug discovery could halt spread of brain cancer inverse relationship between microrna and expression with increasing conjunctival inflammation during ocular chlamydia trachomatis infection scientists discover genetic changes linked to a major risk factor for blinding trachoma the large scale influence of the great barrier reef matrix on wave attenuation great barrier reef is an effective wave absorber in situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer simple shell of plant virus sparks immune response against cancer hpv prevalence in multiple anatomical sites among men who have sex with men in peru high hpv prevalence found in subset of peruvian men trends and variation in prescribing of low priority treatments identified by nhs england a cross sectional study and interactive data tool in english primary care prescription costs increase for low value treatments despite reduction in numbers tall amazonian forests are less sensitive to precipitation variability tall and older amazonian forests more resistant to droughts association of hla drb haplotypes with rheumatoid arthritis severity mortality and treatment response gene variants show potential in predicting rheumatoid arthritis disease outcomes air pollution exposure during fetal life brain morphology and cognitive function in school age children air pollution linked to brain alterations and cognitive impairment in children prenatal ethanol exposure disrupts intraneocortical circuitry cortical gene expression and behavior in a mouse model of fasd prenatal exposure to alcohol disrupts brain circuitry no safe level of drinking during pregnancy neuroscientist says cell type restricted activity of hnrnpm promotes breast cancer metastasis via regulating alternative splicing stopping the spread of breast cancer newly discovered pathway may advance treatment historic drought puts the brakes on earthflows in northern california authors slowing of landslide flows reflects california s drying climate exploring the effects of extension workshops on household water use behavior can workshops on household water use impact consumer behavior ? predicting the diagnosis of autism spectrum disorder using gene pathway analysis genetic test predicts risk for autism spectrum disorder eosinophil progenitor levels are increased in patients with active pediatric eosinophilic esophagitis scientists identify potential marker of eoe disease activity biases in detection of apparent weekend effect on outcome with administrative coding data population based study of stroke inaccurate coding of patient data may explain weekend effect safety of seasonal influenza vaccination in hospitalized surgical patients no increased risk in providing flu vaccine to surgical patients new study finds mitogenomic sequences support a north south subspecies subdivision withinsolenodon paradoxus endangered venomous mammal predates dinosaurs extinction study confirms long term exposure to fine particulate matter residential proximity to major roads and measures of brain structure long term exposure to air pollution may pose risk to brain structure cognitive functions identification of tnf related apoptosis inducing ligand and other molecules that distinguish inflammatory from resident dendritic cells in patients with psoriasis new study of psoriatic cells could fire up the study of inflammation on a collision course competition and dispersal differences create no analogue communities and cause extinctions during climate change climate change models may underestimate extinctions animals and plants could be on a collision course created by climate change an ebola whole virus vaccine is protective in nonhuman primates ebola whole virus vaccine shown effective safe in primates sulfur availability regulates plant growth via glucose tor signaling distant relatives tor protein regulates cell growth in plants and animals dna methylation profiling in breast cancer discordant identical twins identifies dok as novel epigenetic biomarker epigenetic difference in twins explains different risk of breast cancer neuroethical and social implications of using transcranial electrical stimulation to augment creative cognition use of electrical brain stimulation to foster creativity has sweeping implications archaeogenomic evidence from the southwestern us points to a pre hispanic scarlet macaw breeding colony scarlet macaw dna points to ancient breeding operation in southwest ice sheet contributions to future sea level rise from structured expert judgment better understanding of the effect of melting ice sheets experts weigh in from venison to beef seasonal changes in wolf diet composition in a livestock grazing landscape gps study shows wolves more reliant on a cattle diet earth s magnetosphere and outer radiation belt under sub alfv nic solar wind researchers discover effect of rare solar wind on earth s radiation belts clarifying the relationship of parental bonding to suicide ideation and attempts caring youth parent relations can be vital to preventing adolescent suicide attempts traumatic brain injury in a prison population prevalence and risk for re offending concern over traumatic brain injury in youth offenders an optimized synthetic dna vaccine encoding the toxin a and toxin b receptor binding domains of clostridium difficile induces protective antibody responses in vivo c. difficile vaccine proves safe percent effective in animal models trkb mediated protection against circadian sensitivity to noise trauma in the murine cochlea circadian clock in the ear time of day of hearing damage affects healing systems genetics identifies sestrin as a regulator of a proconvulsant gene network in human epileptic hippocampus new systems genetics study identifies possible target for epilepsy treatment the impact of primary sjogren s syndrome on female sexual function female patients with primary sj gren s syndrome more likely to experience sexual dysfunction densities and drivers of sea turtle populations across pacific coral reef ecosystems immense pacific coral reef survey shows green sea turtle populations increasing poverty household chaos and interparental aggression predict children s ability to recognize and modulate negative emotions fighting parents hurt children s ability to recognize and regulate emotions gonadotropin dose is negatively correlated with live birth rate analysis of more than assisted reproductive technology cycles study counters long time practice of prescribing more fertility hormones modest changes to glycemic regulation are sufficient to maintain glucose flux in healthy humans following overfeeding with a habitual macronutrient composition it s ok to indulge once in a while study suggests the body adapts to occasional short term overeating seite articles page of original article breast cancer in young women after treatment for hodgkin s disease during childhood or adolescence an observational study with up to year follow up long term study breast cancer risk increased in young women after treatment for hodgkin s disease robust classification of salient links in complex networks skeleton key diverse complex networks have similar skeletons tajima s d and site specific nucleotide frequency in a population during an infectious disease outbreak statistical test relates pathogen mutation to infectious disease progression upper plate controls on co seismic slip in the magnitude. tohoku oki earthquake new study pinpoints stress factor of mega earthquake off japan comparative mortality risk of anemia management practices in incident hemodialysis patients study of popular anemia drug supports new guidelines for its use in dialysis patients mucus secreting lips offer protection to suction feeding corallivorous fishes with specialized lips these fish dine on razor sharp stinging corals real world effectiveness of e cigarettes when used to aid smoking cessation a cross sectional population study e cigarette use for quitting smoking associated with improved success rates pregnancy weight gain and childhood body weight a within family comparison. mom s weight gain during pregnancy tied to childhood obesity the histone variant macroh a suppresses melanoma progression through regulation of cdk breakthrough in melanoma research protein suppresses progression of melanoma in vivo evasion of mxa by avian influenza viruses requires human signature in the viral nucleoprotein new mouse developed that could provide advance warning of next flu pandemic prevalence and trends in obesity and severe obesity among children in the united states sugar sweetened beverages contribute to u.s. obesity epidemic particularly among children size restrictions on the passage of overwintering halyomorpha halys hemiptera pentatomidae through openings no stink bugs allowed study shows size of gaps needed for invasion a rare urachal cyst in a case of ketamine induced cystitis provides mechanistic insights new effects of ketamine abuse uncovered extreme pain bladder damage use of structured expert judgment to forecast invasions by bighead and silver carp in lake erie asian carp could establish in lake erie with little effect to fishery neighborhoods and infectious disease risk acquisition of chlamydia during the transition to young adulthood living in poor area as teen could increase risk for chlamydia in young adulthood low oxygen eddies in the eastern tropical north atlantic implications for n o cycling extreme low oxygen eddies in the atlantic produce greenhouse gases mechanisms of team sport related brain injuries in children to years old opportunities for prevention new study aims to prevent sports related brain injury in youngsters nitration of microtubules blocks axonal mitochondrial transport in a human pluripotent stem cell model of parkinson s disease study uncovers cause of pesticide exposure parkinson s link the ubiquitin ligase ubr suppresses proteostasis collapse in pluripotent stem cells from huntington s disease patients researchers discover system that could reduce neurodegeneration in huntington s disease self induced dust traps overcoming planet formation barriers spontaneous dust traps astronomers discover a missing link in planet formation integrated delivery of antiretroviral treatment and pre exposure prophylaxis to hiv serodiscordant couples a prospective implementation study in kenya and uganda very low transmission of hiv within couples receiving both art prep integrative characterization of the r mouse model of huntington s disease reveals dysfunctional astrocyte metabolism new piece in the huntington s disease puzzle adverse health outcomes in women exposed in utero to diethylstilbestrol women exposed to synthetic estrogen diethylstilbestrol des in the womb face increased cancer risk study finds l lactate protects neurons against excitotoxicity implication of an atp mediated signaling cascade how a waste product of exercise protects neurons from trauma damage descriptive anatomy of the largest known specimen of protoichthyosaurus prostaxalis reptilia ichthyosauria including computed tomography and digital reconstruction of a three dimensional skull medical scanner helps to unlock the mysteries of a giant prehistoric marine reptile bacteriome and mycobiome interactions underscore microbial dysbiosis in familial crohn s disease fungus in humans identified for first time as key factor in crohn s disease association of changes in neighborhood level racial residential segregation with changes in blood pressure among black adults leaving segregated neighborhoods reduces blood pressure for blacks amelioration of arthritis through mobilization of peptide specific cd regulatory t cells rheumatoid arthritis prevented in mice infusions of regulatory t cells turn off autoimmune attack on joints phase ii prospective randomized trial of a low fat diet with fish oil supplementation in men undergoing radical prostatectomy you are what you eat low fat diet with fish oil slows growth of human prostate cancer cells study suggests a genetic system to assess in vivo the functions of histones and histone modifications in higher eukaryotes on the trail of the epigenetic code test system on drosophila should provide the key to histone function novel khz high frequency therapy hf therapy is superior to traditional low frequency spinal cord stimulation for the treatment of chronic back and leg pain new therapy delivers long term relief for chronic back leg pain study finds early puberty negative peer influence and problem behaviors in adolescent girls problem child behavior could result from early puberty in girls temporal niche expansion in mammals from a nocturnal ancestor after dinosaur extinction mammals switched to daytime activity after dinosaur extinction a randomised controlled trial of bumetanide in the treatment of autism in children promising clinical trial to reduce the severity of autistic disorders late onset asthma predicts cardiovascular disease events the wisconsin sleep cohort late onset asthma linked to increased heart disease stroke risk health system loyalty programs an innovation in customer care and service they work for stores and airlines could customer loyalty programs work in health care too ? metabolism related micrornas in maternal breast milk are influenced by premature delivery premature infants may get metabolic boost from mom s breast milk dynamic modulation of inflammatory pain related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor optical control of a neuroreceptor alleviates chronic pain sun protective behaviors in patients with cutaneous hyperpigmentation a cross sectional study patients with hyperpigmentation more likely to use sunscreen few use other sun protection measures mir b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome enriched extracellular particles new molecular level understanding of the brain s recovery after stroke skps derive from hair follicle precursors and exhibit properties of adult dermal stem cells new skin stem cells surprisingly similar to those found in embryos exergaming to improve physical and mental fitness in children and adolescents with autism spectrum disorders pilot study exergaming improves physical mental fitness in children with autism spectrum disorders water use efficiency and relative growth rate mediate competitive interactions in sonoran desert winter annual plants competition in rough neighborhood plant success in desert environment ovarian fluid allows directional cryptic female choice despite external fertilization female fish can favor sperm from preferred males despite external fertilization microbial decomposition of marine dissolved organic matter in cool oceanic crust deep water aquifer acts like natural bio reactor allowing microbes to consume carbon pet changes management and improves prognostic stratification in patients with recurrent colorectal cancer results of a multicenter prospective study pet scans lead to treatment changes in majority of colorectal cancer patients inhibition of neuroinflammation by aibp spinal effects upon facilitated pain states single injection alleviates chemotherapy pain for months in mice life on the edge thermal optima for aerobic scope of equatorial reef fishes are close to current day temperatures fish living near the equator will not thrive in the warmer oceans of the future long term changes in crash rates after introduction of a graduated driver licensing decal provision new jersey s teen driver decals show sustained link with fewer crashes blacklisting variants common in private cohorts but not in public databases optimizes human exome analysis researchers use blacklist computing concept as novel way to streamline genetic analysis toll like receptor polymorphisms influence mother to child transmission of human immunodeficiency virus type gene change raises odds of mother to child hiv transmission bamboo specialists from two mammalian orders primates carnivora share a high number of low abundance gut microbe separated since the dinosaurs bamboo eating lemurs pandas share common gut microbes demographic trends of adults in new york city opioid treatment programs an aging population adults aged now largest age group in opioid treatment programs chemistry supports the identification of gender specific reproductive tissue in tyrannosaurus rex pregnant t. rex could aid in dino sex typing a remarkable short snouted horned dinosaur from the late cretaceous late campanian of southern laramidia big nosed long horned dinosaur discovered in utah dinosaur in same family as triceratops a new maldane species and a new maldaninae genus and species maldanidae annelida from coastal waters of china old specimens establish a new bamboo worm genus species continuous positive airway pressure for children with undifferentiated respiratory distress in ghana an open label cluster crossover trial applying continuous airway pressure improves respiratory and survival rates in children association between burn injury and mental illness among burn survivors a population based self matched longitudinal cohort study mental health visits spike prior to burn injury indicating opportunity for intervention gene expression patterns associated with caste and reproductive status in ants worker specific genes are more derived than queen specific ones novel genes determine division of labor in insect societies developmentally inspired shrink wrap polymers for mechanical induction of tissue differentiation bioinspired sponge like shrinking gel steers tooth tissue formation lower risk cannabis use guidelines a comprehensive update of evidence and recommendations lowering health risks of cannabis use with new public health guidelines in california not for profit hospitals spent more operating expenses on charity care than for profit hospitals spent not for profit hospitals may not trump for profits in providing uncompensated care green as the gospel the power of stewardship messages to improve climate change attitudes. messages of stewardship affect christians attitudes about climate change required growth facilitators propel axon regeneration across complete spinal cord injury a recipe for regenerating nerve fibers across complete spinal cord injury exponential growth combined with exponential decline explains lifetime performance evolution in individual and human species sport performance follows a physiological law study suggests peak at years of age then irreversible decline directed differentiation of human pluripotent stem cells into intestinal tissue in vitro stem cells turned into complex functioning intestinal tissue in lab reduced corneal nerve fiber density in type diabetes by wide area mosaic analysis nerve damage in type diabetes can be detected in the eye ion concentrations in ice wedges an innovative approach to reconstruct past climate variability driving a wedge into historic gaps of climate science hydroxychloroquine inhibits autophagy to potentiate antiestrogen responsiveness in er breast cancer tamoxifen resistant breast cancer reversed when drug paired with anti malaria agent genotype to phenotype relationships in autism spectrum disorders diverse autism mutations lead to different disease outcomes the portion of health care costs associated with lifestyle related modifiable health risks based on a sample of employees in seven industries unhealthy choices cost company health care plans billions of dollars striatal opioid receptor availability is related to acute and chronic pain perception in arthritis people can raise their pain threshold by altering brain chemistry study in arthritis patients shows seismic site response analysis for ottawa canada a comprehensive study using measurements and numerical simulations city of ottawa canada sits atop soil geologic features that amplify seismic waves gene therapy provides long term visual function in a pre clinical model of retinitis pigmentosa two novel treatments for retinitis pigmentosa move closer to clinical trials increased time to pregnancy is associated with suboptimal neurological condition of year olds increased time to pregnancy linked to child s neurological development human antibodies to the dengue virus e dimer epitope have therapeutic activity against zika virus infection antibody protects against zika and dengue mouse study shows the impact of fear on emotional brand attachment the business of fear can our favorite products provide emotional support ? decline in diarrhea mortality and admissions after routine childhood rotavirus immunization in brazil a time series analysis routine rotavirus vaccination in brazil has reduced diarrhea deaths in children do fast foods cause asthma rhinoconjunctivitis and eczema ? global findings from the international study of asthma and allergies in childhood isaac phase three fast food diet linked to asthma and eczema severity in kids large study finds alcohol challenge responses predict future alcohol use disorder symptoms a year prospective study effects of alcohol in young binge drinkers predicts future alcoholism food insecurity and food choices in rural older adults with diabetes receiving nutrition education via telemedicine greater food insecurity from recession poses increased risk to low income individuals with diabetes two new genera and three new species of epipaschiinae meyrick from china lepidoptera pyralidae two new snout moth genera and three new species discovered in southern china metal concentrations in e cigarette liquid and aerosol samples the contribution of metallic coils lead and other toxic metals found in e cigarette vapors ccr receptor antagonists block metastasis to bone of v src oncogene transformed metastatic prostate cancer cell lines hiv drug blocks bone metastases in prostate cancer aortic valve replacement for severe aortic valve stenosis in the nonagenarian patient aortic valve replacement appears safe effective in very elderly patients the clavata receptor fasciated ear responds to distinct cle peptides by signaling through two downstream effectors unique communication strategy discovered in stem cell pathway controlling plant growth the progeny of a cosmic titan a massive multi component proto supercluster in formation at z. in vuds astronomers find a cosmic titan in the early universe stereotyped synaptic connectivity is restored during circuit repair in the adult mammalian retina selective neural connections can be reestablished in retina after injury prediction of childhood asthma using conditional probability and discrete event simulation new statistic model forecasts effect of tobacco consumption on childhood asthma matrix stiffness drives epithelial mesenchymal transition and tumour metastasis through a twist g bp mechanotransduction pathway breast tumor stiffness metastasis risk linked by molecule s movement worldwide phylogenetic distributions and population dynamics of the genus histoplasma global fungal threat six new species associated with bat evolution lifetime smoking history and risk of lung cancer results from the framingham heart study lung cancer risk drops substantially within five years of quitting new research finds the projected timing of climate departure from recent variability urgent new time frame for climate change revealed by massive analysis stellar spectroscopy in the near infrared with a laser frequency comb habitable zone planet finder enables discovery of planets around cool stars consumption of unprocessed cow s milk protects infants from common respiratory infections pediatric allergology fresh milk keeps infections at bay in vivo excision of hiv provirus by sacas and multiplex single guide rnas in animal models gene editing strategy eliminates hiv infection in live animals predicting drug responsiveness in human cancers using genetically engineered mice mouse study predicts cancer drug responsiveness in human tumors epistemic beliefs role in promoting misperceptions and conspiracist ideation reliance on gut feelings linked to belief in fake news peaches preceded humans fossil evidence from sw china eat a paleo peach first fossil peaches discovered in southwest china low diversity of the gut microbiota in infants with atopic eczema high intestinal microbial diversity safeguards against allergies study suggests clear widens the field for observations of the sun with multi conjugate adaptive optics next generation optics offer the widest real time views of vast regions of the sun measurement under the microscope high variability and limited construct validity in emergency department patient experience scores major measurement issues found in emergency department patient experience data survival after lumpectomy and mastectomy for early stage invasive breast cancer less invasive treatment is associated with improved survival in early stage breast cancer bullying involvement and autism spectrum disorders prevalence and correlates of bullying involvement among adolescents with an autism spectrum disorder study details bullying involvement for adolescents with autism spectrum disorder gut microbe generated trimethylamine n oxide from dietary choline is prothrombotic in subjects gut bacteria may turn common nutrient into clot enhancing compound a tunable mechanism determines the duration of the transgenerational small rna inheritance in c. elegans biological mechanism passes on long term epigenetic memories intra laboratory validation of microplate methods for total phenolic content and antioxidant activity on polyphenolic extracts and comparison with conventional spectrophotometric methods new methods for maintaining the quality of minimally processed potatoes for days without the use of sulphites dance and music training have different effects on white matter diffusivity in sensorimotor pathways how the performing arts can set the stage for more developed brain pathways cohabiting men s preferences for and roles in determining the outcomes of unexpected pregnancies men s views of abortion depend more on social class and circumstances than on fixed beliefs interviews reveal specific gata factors act as conserved inducers of an endodermal emt new genetic program converts static cells into mobile invasive cells cluster randomized controlled trial of an hiv sexually transmitted infection risk reduction intervention for south african men researchers run successful hiv intervention project in s. africa orecasted trends in disability and life expectancy in england and wales up to a modelling study aging population with care needs set to grow by within a decade in england and wales binding of the fap protein of fusobacterium nucleatum to human inhibitory receptor tigit protects tumors from immune cell attack bacteria protect intestinal tumor model from being killed by immune cells blimp mediated cd t cell exhaustion causes cd t cell dysfunction during chronic toxoplasmosis protein critical to toxoplasmosis regulation cd t cell and blimp the role of intervening hospital admissions on trajectories of disability in the last year of life prospective cohort study of older people hospital admissions strongly linked to disability for older adults in last year of life autism and mental retardation among offspring born after in vitro fertilization ivf for male infertility linked to increased risk of intellectual disability and autism in children parkinson s disease and parkinson s disease medications have distinct signatures of the gut microbiome link between microbiome in the gut parkinson s discovered human endothelial colony forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling research team pursues techniques to improve elusive stem cell therapy generation of digoxigenin incorporated probes to enhance dna detection sensitivity new method detects telomere length for research into cancer aging solarium use and risk for malignant melanoma meta analysis and evidence based medicine systematic review no definitive causal link between sunbed use and malignant melanoma delivery of a proapoptotic peptide to egfr positive cancer cells by a cyclic peptide mimicking the dimerization arm structure of egfr opening up a drug delivery route discovery of a new vehicle peptide repression of the central splicing regulator rbfox is functionally linked to pressure overload induced heart failure protein s pivotal role in heart failure discovered epidemiology and clinical predictors of biphasic reactions in children with anaphylaxis how to predict biphasic allergic reactions in children clinical outcomes with dose escalated adaptive radiation therapy for urinary bladder cancer a prospective study study finds adaptive igrt for bladder preservation clinically feasible the dcps inhibitor rg improves survival function and motor unit pathologies in two sma mouse models candidate drug provides benefit in spinal muscular atrophy animal models reduced evolutionary rate in reemerged ebola virus transmission chains ebola virus genome provides clues to repeated disease flare ups in western africa tracking the geographical spread of avian influenza h n with multiple phylogenetic trees scientists put interactive flu tracking at public s fingertips mission analysis and component level sensitivity study of hybrid electric general aviation propulsion systems putting hybrid electric aircraft performance to the test the effect of strain on the electrical conductance of p type nanocrystalline silicon carbide thin films research shows benefits of silicon carbide for sensors in harsh environments age related shift in ltd is dependent on neuronal adenosine a a receptors interplay with mglur and nmda receptors new mechanism involved in memory loss associated with aging discovered high prevalence of undiagnosed insulin resistance in non diabetic subjects with parkinson s disease insulin resistance under diagnosed in non diabetics with parkinson s disease individual differences in nonsymbolic ratio processing predict symbolic math performance basic ratio capacity may serve as building block for math knowledge molecular phylodynamics of the heterosexual hiv epidemic in the united kingdom scientists determine dynamics of hiv transmission in uk heterosexuals a new species of nocturnal gecko paroedura from karstic limestone in northern madagascar new species of nocturnal gecko from northern madagascar a child with epidermolytic ichthyosis from a parent with epidermolytic nevus risk evaluation of transmission from mosaic to germline skin disease caused by sperm cell transmission of keratin mutation a multidecade experiment shows that fertilization by salmon carcasses enhanced tree growth in the riparian zone sockeye carcasses tossed on shore over two decades spur tree growth children can foster climate change concern among their parents climate education for kids increases climate concerns for parents arabinogalactan isolated from cowshed dust extract protects mice from allergic airway inflammation and sensitization what protects farm children from hay fever ? protective substance may slumber in cowshed dust tdp depletion in microglia promotes amyloid clearance but also induces synapse loss overactive scavenger cells may cause neurodegeneration in alzheimer s medicaid expansion and access to care among cancer survivors a baseline overview even before aca cancer survivors in non expansion states had less health care access evaluation of accuracy dependence of raman spectroscopic models on the ratio of calibration and validation points for non invasive glucose sensing researchers show effectiveness of new noninvasive blood glucose test anaerobic oxidation of ethane by archaea from a marine hydrocarbon seep knowledge gap closed in our understanding of degradation of ethane use of thiazolidinediones and the risk of bladder cancer among people with type diabetes a meta analysis some diabetes drugs may increase risk of bladder cancer dynamics of brain activity underlying working memory for music in a naturalistic condition hippocampal activity during music listening exposes the memory boosting power of music association between insurance status and access to hospital care in emergency department disposition study links insurance coverage to access to hospital care association between oropharyngeal carriage of kingella kingae and osteoarticular infection in young children a case control study children with bone joint infection often carry the same infectious bacteria in throat rebounding droplet droplet collisions on superhydrophobic surfaces from the phenomenon to droplet logic towards computing with water droplets superhydrophobic droplet logic projecting changes in societally impactful northeastern u.s. snowstorms major northeastern u.s. snowstorms expected to continue with climate change the light skin allele of slc a in south asians and europeans shares identity by descent genetic study on south asians helps to understand human skin color variation a compact synthetic pathway rewires cancer signaling to therapeutic effector release synthetic biology used to target cancer cells while sparing healthy tissue genetic ancestry and population differences in levels of inflammatory cytokines in women role for evolutionary selection and environmental factors threat of malaria left its mark on the immune system in people with african ancestry effect of repeated trace mineral injections on beef heifer development and reproductive performance injectable trace minerals improve mineral status in beef heifers year quantitative reconstruction of winter precipitation in the pacific northwest pinpointing history of droughts through exploration of tree rings unexpected complexity in u. s. west s patterns of drought phylogenomics reveals rapid simultaneous diversification of three major clades of gondwanan frogs at the cretaceous paleogene boundary dinosaurs loss was frogs gain the upside of a mass extinction selective fast response and regenerable metal organic framework for sampling excess fluoride levels in drinking water new device simplifies measurement of fluoride contamination in water mapping brain activity with flexible graphene micro transistors graphene based neural probes probe brain activity in high resolution a national sample of eighth grade students the impact of middle grade schools on academic and psychosocial competence attending a middle vs k school matters for student outcomes excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking scientists use optogenetics to control reward seeking behavior a pilot study of group mindfulness based cognitive therapy mbct for combat veterans with posttraumatic stress disorder ptsd mindfulness therapy might help veterans with combat related post traumatic stress disorder school organizational contexts teacher turnover and student achievement evidence from panel data school environment key to retaining teachers promoting student achievement coenzyme q benefits symptoms in gulf war veterans results of a randomized double blind study coenzyme q helps veterans battle gulf war illness symptoms researchers report testing the effects of social norms and behavioral privacy on hand washing a field experiment specialized messages increase likelihood of male hand washing technical note the use of geographical information systems software for the spatial analysis of bone microstructure new tool for csi ? geographic software maps distinctive features inside bones effects of geographical heterogeneity in species interactions on the evolution of venom genes predatory snails evolved diverse venoms to subdue a wide range of prey species temporal trends of persistent organic pollutants in arctic marine and freshwater biota many arctic pollutants decrease after market removal and regulation factors associated with onset timing symptoms and severity of depression identified in the postpartum period postpartum depression least severe form of depression in mothers interseismic coupling based earthquake and tsunami scenarios for the nankai trough modeling future earthquake and tsunami risk in southwestern japan understanding trends in australian alcohol consumption an age period cohort model new study shows a generational shift toward lighter drinking in australia acquisition of hiv resistance in t lymphocytes using an aca specifice. colimrna interferase new anti hiv gene therapy makes t cells resistant to hiv infection antagonistic effects of bace and aph b secretase control axonal guidance by regulating growth cone collapse alzheimer s disease related proteases control axonal guidance by regulating growth cone dynamics usingin situmanagement to conserve biodiversity under climate change land management could help wildlife beat the challenges brought by climate change experiences of coeliac disease in a changing gluten free landscape how has the gluten free industry affected individuals with celiac disease ? trem shedding by cleavage at the h s bond is accelerated for the alzheimer s disease associated h y variant stabilizing trem a potential strategy to combat alzheimer s disease lymphotoxin dependent b cell frc crosstalk promotes de novo follicle formation and antibody production following intestinal helminth infection intestinal worms boost immune system in a surprising way caregiver presence and patient completion of a transitional care intervention patients benefit from caregiver involvement in hospital discharge intervention risks for the global freshwater system at. c and c global warming global warming of. c or c the lower limit would reduce flood hazards current global warming appears anomalous in relation to the climate of the last years new study shows no simultaneous warming of northern and southern hemispheres as a result of climate change for years the evolution of the faint end of the uv luminosity function during the peak epoch of star formation lt z lt large number of dwarf galaxies discovered in the early universe aurora kinase a drives the evolution of resistance to third generation egfr inhibitors in lung cancer cancer researchers id achilles heel of drug resistant tumors a genetically encoded probe for live cell imaging of h k monomethylation catching histones by the tail a new probe to track histone modifications in living cells realistic worst case for a severe space weather event driven by a fast solar wind stream satellites more at risk from fast solar wind than a major space storm detection of genetic cardiac diseases by ca transient profiles using machine learning methods diagnostics of genetic cardiac diseases using stem cell derived cardiomyocytes opioids and infectious diseases a converging public health crisis opioid epidemic is increasing rates of some infectious diseases biomechanics of hover performance in neotropical hummingbirds versus bats engineers study hovering bats and hummingbirds in costa rica recommendations for conduct methodological practices and reporting of cost effectiveness analyses new set of recommendations developed to improve quality of cost effectiveness analyses seasonal trivalent influenza vaccination during pregnancy and the incidence of stillbirth population based retrospective cohort study seasonal influenza vaccination during pregnancy may reduce risk of stillbirth tumour hypoxia causes dna hypermethylation by reducing tet activity normalizing tumor oxygen supply could be key factor in the fight against cancer gulf stream rings as a source of iron to the north atlantic subtropical gyre gulf stream eddies as a source of iron common genetic variation drives molecular heterogeneity in human ipscs scientists unveil the uk s largest resource of human stem cells from healthy donors a microfluidic device for epigenomic profiling using cells technology helps personalized medicine enabling epigenomic analysis with a mere cells characterization of t cell responses in macaques immunized with a single dose of hiv dna vaccine single dose hiv dna vaccine induces long lasting immune response in monkeys regional growth decline of sugar maple acer saccharum and its potential causes new study rings alarm for sugar maple in adirondacks extracts of polypore mushroom mycelia reduce viruses in honey bees fungus provides powerful medicine in fighting honey bee viruses factors influencing the decline in stroke mortality a statement from the american heart association american stroke association us stroke deaths declining due to improved prevention treatment mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor reactive t cells new screening approach quickly identifies small proteins unique to melanoma cells focal radiation therapy combined with bb activation and ctla blockade yields long term survival and a protective antigen specific memory response in a murine glioma model triple therapy revs up immune system against common brain tumor changes in neuropsychological tests and brain metabolism after bariatric surgery brain benefits from weight loss following bariatric surgery anthelmintic avermectins kill m. tuberculosis including multidrug resistant clinical strains repurposed anti parasite drug shows promise as new tuberculosis treatment research finds expanded hiv clinic based mental health care services association with viral suppression successful hiv effort prompts call for clinics to expand mental health services on site randomized trial of motivational interviewing plus feedback for soldiers with untreated alcohol abuse. telephone based intervention shows promise in combating alcohol abuse among soldiers opposing effects of pigment epithelium derived factor on breast cancer cell versus neuronal survival implication for brain metastasis and metastasis induced brain damage agent shows ability to suppress brain metastasis and related damage changes in insurance coverage among hospitalized nonelderly adults after medicaid expansion in michigan medicaid expansion brought across the board relief for michigan hospitals projected impact of dengue vaccination in yucat n mexico potential impact of a dengue vaccine in the yucatan mutant fus causes dna ligation defects to inhibit oxidative damage repair in amyotrophic lateral sclerosis neuroscientists find molecular clue in als suggesting potential new drug target identification of four unique spending patterns among older adults in the last year of life challenges standard assumptions four paths to the end of life one far more expensive than others emerge in new study anthropogenic strath terrace formation caused by reduced sediment retention historic logging site shows first human caused bedrock erosion along an entire river differentiation of pluripotent stem cells to muscle fiber to model duchenne muscular dystrophy muscle fibers grown in the lab offer new model for studying muscular dystrophy the effects of anaerobic soil disinfestation on weed and nematode control fruit yield and quality of florida fresh market tomato sustainable alternative to methyl bromide for tomato production continuous modeling of arterial platelet thrombus formation using a spatial adsorption equation biophysicists develop a model for arterial thrombus formation acute hiie elicits similar changes in human skeletal muscle mitochondrial h o release respiration and cell signaling as endurance exercise even with less work crunched for time ? high intensity exercise gives same cell benefits in fewer minutes mutations in grin a cause idiopathic focal epilepsy with rolandic spikes disease gene discovered for frequent epilepsy in childhood the chronology of reindeer hunting on norway s highest ice patches frozen in time glacial archaeology on the roof of norway odontoma in a million year old mammalian forebear fossilized evidence of a tumor in a million year old mammal forerunner the angelman syndrome associated ubiquitin ligase ube a regulates synapse development by ubiquitinating arc loss of enzyme reduces neural activity in angelman syndrome hypoxia inducible factors in human pulmonary arterial hypertension a link to the intrinsic myeloid abnormalities close linkage between a rare deadly lung condition and blood cell abnormalities longitudinal study of amygdala volume and joint attention in to year old children with autism brain abnormalities associated with social orienting ability found in toddlers with autism according to imaging study the effect of delaying childbirth on primary cesarean section rates delaying childbirth is associated with impaired contraction of the uterus and rising rates of cesarean section zoledronic acid acutely increases sclerostin serum levels in women with postmenopausal osteoporosis common osteoporosis drug slows formation of new bone methotrexate in combination with other dmards is not superior to methotrexate alone for remission induction with moderate to high dose glucocorticoid bridging in early rheumatoid arthritis after weeks of treatment the carera trial new effective safe and cheap treatment strategy for rheumatoid arthritis zebrafish as an animal model in epilepsy studies with multichannel eeg recordings multichannel eeg recordings enable precise brain wave measurement of fish tau protein aggregation is associated with cellular senescence in the brain stressed toxic zombie cells seen for st time in alzheimer s stepwise chromatin remodelling by a cascade of transcription initiation of non coding rnas early stage gene transcription creates access to dna amphetamine and opioid affected births incidence outcomes and costs united states more pregnant women are using meth and opioids study finds site specific positioning of dendritic alkyl chains on dna cages enables their geometry dependent self assembly using dna strands to design new polymer materials calcium and vitamin d supplementation and loss of bone mineral density in women undergoing breast cancer therapy calcium supplements may not prevent bone loss in women with breast cancer timing and number of minor infections as risk factors for childhood arterial ischemic stroke colds and other common infections tied to some stroke risk in kids cardiovascular events in early rheumatoid arthritis ra are a result of inflammatory burden and traditional risk factors a five year prospective study arthritis sufferers increased risk of heart disease due to disease related inflammation and other factors study finds effect of soy isoflavones on breast cancer recurrence and death for patients receiving adjuvant endocrine therapy soy intake associated with lower recurrence of breast cancer in hormone sensitive cancers mass azithromycin distribution for hyperendemic trachoma following a cluster randomized trial a continuation study of randomly reassigned subclusters tana ii ethiopian year trial finds that childhood eye infection increases after antibiotic program ends state variation in underreporting of alcohol involvement on death certificates motor vehicle traffic crash fatalities as an example alcohol s role in traffic deaths vastly underreported u.s. study finds sleep disorder diagnosis during pregnancy and risk of preterm birth sleep disorders linked to preterm birth in large california study c orf repeat expansions in mice cause tdp pathology neuronal loss and behavioral deficits new mouse model for als and frontotemporal dementia gene offers hope for potential therapies differences in clinical and functional outcomes of atrial fibrillation in women and men two year results from the orbit af registry compared with men women with afib have more symptoms worse quality of life although higher survival transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients first stem cell study of bipolar disorder yields promising results rig i uses an atpase powered translocation throttling mechanism for kinetic proofreading of rnas and oligomerization like a butterfly immune protein flutters in search of viruses vitamin d status and rates of cognitive decline in a multiethnic cohort of older adults low vitamin d among elderly associated with decline in cognition dementia ecogeographical gradients in plumage coloration among australasian songbird clades plumage evolution explaining the vivid colors of birds drastic decrease of the hiv reservoir in a patient treated with nivolumab for lung cancer cancer drug leads to drastic decrease in hiv infection in lung cancer patient overcoming barriers in evaluating outbreaks of diarrheal disease in resource poor settings assessment of recurrent outbreaks in chobe district botswana researchers help people in remote africa respond to diarrheal disease declining population trends of hawaiian petrel and newell s shearwater on the island of kaua i hawaii usa steep declines in kauai s seabird populations radar reveals aire deficient patients harbor unique high affinity disease ameliorating autoantibodies antibodies in patients with rare disorder may have role preventing type diabetes management of pregnancy in patients with complex congenital heart disease a scientific statement for healthcare professionals from the american heart association women with high risk congenital heart disease can have successful pregnancies death near the shoreline not life on land ordovician arthropod trackways in the borrowdale volcanic group uk early animals death near the shoreline not life on land declines in marathon performance sex differences in elite and recreational athletes differences in sex and running ability influence declines in marathon performance study finds a six country study of young children s media exposure logo recognition and dietary preferences logo recognition associated with kids choice of international junk foods periconceptional maternal micronutrient supplementation is associated with widespread gender related changes in the epigenome a study of a unique resource in the gambia exposure to micronutrients pre pregnancy associated with gene modifications in offspring early weight gain in pregnancy and infant birth weight self control and obesity gender matters in children chronic stress triggers social aversion via glucocorticoid receptor in dopaminoceptive neurons how repeated aggression triggers social aversion in mice antibacterial medication use during pregnancy and risk of birth defects national birth defects prevention study antibiotic use during pregnancy and birth defects study examines associations immature green citrus detection based on colour feature and sum of absolute transformed difference satd using colour images in the citrus grove new method detects of immature citrus helping cut costs meta analysis reveals that hydraulic traits explain cross species patterns of drought induced tree mortality across the globe trees internal water pipes predict which species survive drought tile drainage and anthropogenic land use contribute to harmful algal blooms and microbiota shifts in inland water bodies algal blooms a threat to small lakes and ponds too altered human voice processing in the frontal cortex and a developmental language delay in to year old children with autism spectrum disorder altered voice processing in young children with autism and delayed language development phylloquinone intake is associated with cardiac structure and function in adolescents low consumption of vitamin k by adolescents associated with unhealthy enlargement of the heart s major pumping chamber consensus on consensus a synthesis of consensus estimates on human caused global warming consensus on consensus expertise matters in agreement over human caused climate change clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in asia a phase randomised observer masked placebo controlled trial world s most advanced dengue vaccine candidate shows promise in phase trial design of a biologically inspired lower limb exoskeleton for human gait rehabilitation bio inspired lower limb wearing robotic exoskeleton for human gait rehab single cell rna seq resolves cellular complexity in sensory organs from the neonatal inner ear scientists develop genetic blueprint of inner ear cell development end of life care for patients dying of stroke a comparative registry study of stroke and cancer insufficient knowledge of stroke patient s last hours of life genetic comparisons yield insight into the evolution of enamel thickness during human evolution getting to the root of enamel evolution connecting genes to hominin teeth shows evidence of natural selection multiple antigen presenting system maps to induce comprehensive b and t cell immunity new modular vaccine design combines best of existing vaccine technologies neutrophil to lymphocyte ratio nlr for prediction of distant metastasis free survival dmfs in early breast cancer a propensity score matched analysis high white blood cell ratio linked to recurrence risk in early stage breast cancer microwave enhanced advanced oxidation treatment of lipids and food wastes breaking up fatbergs engineers develop technique to break down fats oil and grease gene repair of an usher syndrome causing mutation by zinc finger nuclease mediated homologous recombination ray of hope for human usher syndrome patients production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccines researchers take a step toward developing a universal flu vaccine dietary docosahexaenoic acid supplementation prevents age related functional losses and a e accumulation in the retina fatty acid found in fish prevents age related vision loss study suggests transcriptomic meta signatures identified in anopheles gambiae populations reveal previously undetected insecticide resistance mechanisms researchers identify additional mechanisms at play in insecticide resistance pesticide reduces bumblebee colony initiation and increases probability of population extinction neonics put bumblebees at risk of extinction by hindering colony formation study reveals serum cortisol mediates the relationship between fecal ruminococcus and brain n acetylaspartate in the young pig gut microbes may talk to the brain through cortisol x ray rheography uncovers planar granular flows despite non planar walls sudoku x ray uncovers movements within opaque materials chromoendoscopy is more effective than standard colonoscopy in detecting dysplasia during long term surveillance of patients with colitis superiority of chromoendoscopy in dysplasia detection in patients with colitis landmark study shows mound construction and site selection in the lafourche subdelta of the mississippi river delta louisiana usa ancient mound builders carefully timed their occupation of coastal louisiana site machine learning approaches to evaluate correlation patterns in allosteric signaling a case study of the pdz domain machine learning techniques may reveal cause effect relationships in protein dynamics data high definition fiber tracking for assessment of neurological deficit in a case of traumatic brain injury finding visualizing and interpreting small sites of damage case report video new high definition fiber tracking reveals damage caused by traumatic brain injury decoupling genetics lineages and microenvironment in idh mutant gliomas by single cell rna seq single cell rna sequencing reveals detailed composition of two major types of brain tumor the reading the mind in the eyes test complete absence of typical sex difference in men and women with autism men and women with autism have extreme male scores on the eyes test of mindreading the state of the antivaccine movement in the united states a focused examination of nonmedical exemptions in states and counties childhood vaccination exemptions rise in parts of the us a three dimensionally preserved lobopodian from the herefordshire silurian lagerst tte uk new species of rare ancient worm discovered in fossil hotspot quality of life is reduced in obese dogs but improves after successful weight loss quality of life of obese dogs improves when they lose weight role of financial and social hardships in asthma racial disparities hardships explain much of hospital asthma readmissions among black children teens cholesterol regulates syntaxin trafficking at trans golgi network endosomal boundaries cholesterol plays key role in cell migration study shows pdgf mediated mesenchymal transformation renders endothelial resistance to anti vegf treatment in glioblastoma additional inhibitor can help anti vegf therapy overcome resistance in deadly brain cancer a comparison of over the counter mechanical nasal dilators review article compared over the counter nasal dilators the frustrating effects of just missing the jackpot slot machine near misses trigger large skin conductance responses but no post reinforcement pauses gamblers in a spin over frustrating losses study explores the physiological and behavioral responses to gambling the pace of morphological change historical transformation of skull shape in st bernard dogs st. bernard study shows human directed evolution at work the prevalence and types of glaucoma in an urban chinese population the singapore chinese eye study study estimates prevalence of glaucoma among singapore chinese fluorescent protein based detection of unconjugated bilirubin in newborn serum fluorescent protein from japanese eel muscles used to detect bilirubin in newborns a defect in myoblast fusion underlies carey fineman ziter syndrome genomic cause for carey fineman ziter syndrome identified drought induces spruce beetle dendroctonus rufipennis outbreaks across northwestern colorado massive spruce beetle outbreak in colorado tied to drought physical firness adiposity and metabolic risk factors in young college students physical fitness may help reduce chronic disease risk in college students rare variants in cardiomyopathy genes associated with stress induced cardiomyopathy genes linked to stress triggered heart disease identified local recruitment of humpback whales in glacier bay and icy strait alaska over years local fidelity key to ocean wide recovery of humpback whales nest etiquette where ants go when nature calls where ants go when nature calls ants use corners of their nest as toilets calcium supplement intake and risk of cardiovascular disease in women calcium supplements not associated with increased risk of cardiovascular disease in women the increased expression of il in inflammatory bowel disease promotes intraepithelial and lamina propria lymphocyte inflammatory responses and cytotoxicity new drug target discovered for inflammatory bowel disease cytokine il parental outcomes following participation in cognitive behavior therapy for children with autism spectrum disorder effects of cognitive behavior therapy on parents of children with autism tracing dynamic changes of dna methylation at single cell resolution new methodology tracks changes in dna methylation in real time at single cell resolution multi potential differentiation of human urine derived stem cells potential for therapeutic applications in urology stem cells in urine easy to isolate and have potential for numerous therapies whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells improved blood stabilization should expand use of circulating tumor cell profiling intracoronary imaging cholesterol efflux and transcriptomes after intensive statin treatment the yellow ii study improved cholesterol efflux linked to plaque stabilization in statin treated patients study finds the bcg world atlas a database of global bcg vaccination policies and practices researchers launch free online atlas of tb vaccination policies from around the world evaluation of the atrophogenic potential of topical corticosteroids in pediatric dermatology patients use of topical corticosteroids in children with eczema does not have negative side effects study finds the temporal dynamics of arc expression regulate cognitive flexibility single protein on off switch controls learning flexibility and acquisition of new memories recovery of active cathode materials from lithium ion batteries using froth flotation old mining techniques make a new way to recycle lithium batteries fraudulent income overstatement on mortgage applications during the credit expansion of to see more at http wws.princeton.edu news and events news item how income fraud made housing bubble worse sthash.ehnnvlmo.dpuf how income fraud made the housing bubble worse traumatic brain injury among men in an urban homeless shelter observational study of rates and mechanisms of injury almost half of homeless men had traumatic brain injury in their lifetime spherical neutron polarimetry under high pressure for a multiferroic delafossite ferrite world s first success in analyzing d neutron polarization under high pressure racial disparities in functional disability among older women with newly diagnosed nonmetastatic breast cancer functional disability high among newly diagnosed older breast cancer patients lsd corest is an allosteric nanoscale clamp regulated by h histone tail molecular recognition molecular movies may accelerate anti cancer drug discovery a role for the werner syndrome protein in epigenetic inactivation of the pluripotency factor oct gene related to aging plays role in stem cell differentiation dietary weight loss and exercise effects on serum biomarkers of angiogenesis in overweight postmenopausal women a randomized controlled trial losing weight lowered levels of proteins associated with tumor growth rethinking stimulation of the brain in stroke rehabilitation why higher motor areas might be better alternatives for patients with greater impairments neuro researchers advocate for shift in thinking for stroke rehabilitation decline in weight and incident mild cognitive impairment mayo clinic study of aging greater weight loss during aging associated with increased risk for mild cognitive impairment a role for nicotinic receptors in a model of local amyloid pathology induced in dentate gyrus alzheimer s nicotinic receptors as a new therapeutic target subnanometer cobalt oxide clusters as selective low temperature oxidative dehydrogenation catalysts scientists pioneer new low temperature chemical conversion process rs polymorphism at the igf h locus associates with genotype specific effects on placental dna methylation and birth weight of newborns conceived by assisted reproductive technology novel information about the effects of in vitro fertilization on embryonic growth nlrp restricts butyrate producing commensals to exacerbate inflammatory bowel disease immune system s balancing act keeps bowel disease in check repeated inversions within a pannier intron drive diversification of intraspecific colour patterns of ladybird beetles a mechanism of color pattern formation in ladybird beetles response of corn markets to climate volatility under alternative energy futures climate change may create price volatility in the corn market incorporating feedback from multiple sensory modalities enhances brain machine interface control robot arm improves performance of brain controlled device rapid viral diagnosis for acute febrile respiratory illness in children in the emergency department promising results for rapid viral diagnosis tests in emergency rooms coronary atherosclerosis in indigenous south american tsimane a cross sectional cohort study indigenous south american group has healthiest arteries of all populations yet studied providing clues to healthy lifestyle living on the edge settlement patterns by the symbiotic barnacle xenobalanus globicipitis on small cetaceans barnacles go with the flow to find a home on dolphin fins hitting rock bottom after job loss bouncing back to create a new positive work identity hitting rock bottom after job loss can be beneficial study shows a randomized trial of epidural glucocorticoid injections for spinal stenosis little benefit seen when corticosteroids added to injections for spinal stenosis enhanced sensitivity to il signaling regulates the clinical responsiveness of il primed cd t cells in a melanoma model scientists discover way to amp up power of killer t cells to fight melanoma generalizing ecological effects of shoreline armoring across soft sediment environments seawalls ecological effects of coastal armoring in soft sediment environments sorafenib regorafenib and phosphatidyl inositol kinase thymoma viral proto oncogene inhibition interact to kill tumor cells drug combination therapy causes cancer cells to eat themselves adolescent substance use in the multimodal treatment study of attention deficit hyperactivity disorder adhd mta as a function of childhood adhd random assignment to childhood treatments and subsequent medication large study shows substance abuse rates higher in teenagers with adhd the atypical cadherin fat directly regulates mitochondrial function and metabolic state fat gene and mitochondria surprising cellular connection sheds new light on energy control conformational plasticity of a native retroviral capsid revealed by x ray crystallography first ever observation of the native capside of a retrovirus association between the use of fondaparinux vs low molecular weight heparin and clinical outcomes in patients with non st segment elevation myocardial infarction anticoagulant linked with lower risk of death following heart attack compared to heparin attitudes to smoke free outdoor regulations in the usa and canada a review of surveys growing public support found in usa canada for smokefree outdoor laws implications of the great east japan tsunami on sea defence design japanese sea defense guidelines could assist other tsunami prone nations study suggests the vegetation greenness trend in canada and us alaska from landsat data greening arctic impact of climate change in high latitudes trends in total cholesterol triglycerides and low density lipoprotein in us adults levels of total cholesterol ldl c triglycerides continue to decline among us adults oral preexposure anti hiv prophylaxis for high risk u.s. populations current considerations in light of new findings early success of anti hiv preventive oral drug regimen is promising but questions remain pten regulation of local and long range connections in mouse auditory cortex gene mutation in autism found to cause hyperconnectivity in brain s hearing center quinine dimers are potent inhibitors of theplasmodium falciparumchloroquine resistance transporter and are active against quinoline resistantp. falciparum new strategy emerges for fighting drug resistant malaria developing teenagers views on their health and the health of their future children students drop their stereotypes of science when they meet the scientist tailoring nanoscopic confines to maximize catalytic activity of hydronium ions biofuel from waste zeolite catalysts pave the road to decentralized chemical processes climate driven thresholds in reactive mineral retention of soil carbon at the global scale six feet under a new approach to global warming neurometabolites and associations with cognitive deficits in mild cognitive impairment a magnetic resonance spectroscopy study at tesla measuring differences in brain chemicals in people with mild memory problems oc dietary carotenoids reduced hip fracture risk in lean men the singapore chinese health study carotenoids found to reduce hip fracture risk in lean men t follicular helper cell plasticity shapes pathogenic t helper cell mediated immunity to inhaled house dust mite new model how asthma develops from exposure to house dust mites the consequence of fetal ethanol exposure and adolescent odor re exposure on the response to ethanol odor in adolescent and adult rats alcohol exposure in the womb affects teenage booze behavior intracranial hemorrhage in patients with brain metastases treated with therapeutic enoxaparin a matched cohort study blood thinner safe for cancer patients with brain metastases rediscovering the positive psychology of sport participation happiness in a ski resort context head out to the ski slopes for happiness sake effect of trans trans farnesol on pseudogymnoascus destructans and several closely related species bat disease yeast byproduct inhibits white nose syndrome fungus in lab experiments effect of day length on eye growth myopia progression and change of corneal power in myopic children outdoor recess time can reduce the risk of nearsightedness in children evidence of shark attacks on atlantic spotted dolphins stenella frontalis off bimini the bahamas shark attacks on atlantic spotted dolphins near the bahamas transplantation of adult mouse ips cell derived photoreceptor precursors restores retinal structure and function in degenerative mice sections of retinas regenerated and visual function increased with stem cells from skin prolonged human neural stem cell maturation supports recovery in injured rodent cns it s not a rat s race for human stem cells grafted to repair spinal cord injuries incidence of trypanosoma cruzi infection in triatomines collected at indio mountains research station high rate of texas bugs carrying chagas disease transport of topical anesthetics in vitamin e loaded silicone hydrogel contact lenses contact lenses provide extended pain relief to laser eye surgery patients functional brain network mechanism of hypersensitivity in chronic pain does an exploding brain network cause chronic pain ? science advancements key to increasing management value of life stage monitoring networks for endangered sacramento river winter run chinook salmon in california scientists call for improved technologies to save imperiled california salmon parallel diversifications of cremastosperma and mosannona annonaceae tropical rainforest trees tracking neogene upheaval of south america geological change confirmed as a factor behind the extensive diversity in tropical rainforests hpv testing on self collected cervicovaginal lavage specimens as screening method for women who do not attend cervical screening cohort study enabling women to use home test kits could increase hpv detection large scale associations between the leukocyte transcriptome and bold responses to speech differ in autism early language outcome subtypes brain responses to language in toddlers with autism linked to altered gene expression randomized controlled trial of high dose influenza vaccine among frail residents of long term care facilities high dose flu vaccine superior for frail elderly living in long term care facilities effect of e bike versus bike commuting on cardiorespiratory fitness in overweight adults four weeks of riding an e bike promotes fitness and health maternal cell phone use in early pregnancy and child s language communication and motor skills at and years the norwegian mother and child cohort study moba mobile phone use while pregnant not linked to child neurodevelopment problems study suggests groundcover management and nutrient source effects on soil carbon and nitrogen sequestration in an organically managed apple orchard in the ozark highlands organic apple orchards benefit from green compost applications gut microbiome function predicts response to anti integrin biologic therapy in inflammatory bowel diseases gut microbiome may predict response to biologic therapy for inflammatory bowel disease integrated molecular genetic profiling of pediatric high grade gliomas reveals key differences with the adult disease push to understand basis of childhood brain tumors leads to a new treatment target the collembolan fauna of maestrazgo caves teruel spain with description of three new species three new arthropod species have been found in the maestrazgo caves in teruel naturalization of central european plants in north america species traits habitats propagule pressure residence time europeans have unknowingly contributed to spread of invasive plant species in north america simvastatin attenuates rhinovirus induced interferon and cxcl secretion from monocytic cells in vitro common cholesterol drug greatly alters inflammatory response to common cold a climate driven functional inversion of connected marine ecosystems warming waters caused rapid and opposite shifts in connected marine communities initial results of a multicenter phase trial of stereotactic ablative radiation therapy for oligometastatic cancer high dose radiation therapy improves long term survival in patients with stage iv cancers trial finds coupling dark metabolism to electricity generation using photosynthetic cocultures working together bacteria join forces to produce electricity a red meat derived glycan promotes inflammation and cancer progression sugar molecule links red meat consumption and elevated cancer risk in mice what makes things cool ? how autonomy influences perceived coolness what makes things cool ? when breaking rules can boost your cool factor seeing the rural healthcare journeys of older adults with atrial fibrillation through a photographic lens digital photography could be a key factor in rural health care global synthesis of drought effects on maize and wheat production researchers identify critical factors that determine drought vulnerability of wheat maize vaccinia virus glv h in combination with i shows increased efficiency in treating triple negative breast cancer engineered virus effective against triple negative breast cancer cells study shows similar effects of disease modifying anti rheumatic drugs glucocorticoids and biologics on radiographic progression in rheumatoid arthritis dmards glucocorticoids and biologics equally effective for rheumatoid arthritis conserved properties of dendritic trees in four cortical interneuron subtypes a d reconstructed image of neural dendritic trees using the advanced electron microscope technology acupuncture for menopausal hot flashes a randomized trial real acupuncture no better than sham acupuncture for treating hot flushes study namibian fairy circles and epithelial cells share emergent geometric order mysterious desert fairy circles share pattern with skin cells social participation among young adults with an autism spectrum disorder social isolation of young adults with autism spectrum disorder examined alt a from alternaria interacts with pr thaumatin like proteins progress in allergic asthma research after ingestion of fruits structural analyses reveal the mechanism of inhibition of influenza virus ns by two antiviral compounds molecular virologist fights influenza at the molecular level cpg island methylator phenotype is associated with response to adjuvant irinotecan based therapy for stage iii colon cancer drug shows promise for subset of stage iii colon cancer patients comprehensive epigenetic landscape of rheumatoid arthritis fibroblast like synoviocytes joint resolution a link between huntington s disease and rheumatoid arthritis evaluating social and ecological vulnerability of coral reef fisheries to climate change study provides insights on protecting world s poor from climate change randomized controlled trial and cost effectiveness analysis of silver donating antimicrobial dressings for venous leg ulcers vulcan trial significant savings on venous leg ulcer dressings identified body mass index is associated with brain metabolite levels in alcohol dependence a multimodal magnetic resonance study excessive drinking may lead to poor brain health via obesity decades of native bee biodiversity surveys at pinnacles national park highlight the importance of monitoring natural areas over time bee surveys in newest us national park could aid pollinator studies elsewhere calcium regulation of hemorrhagic fever virus budding mechanistic implications for host oriented therapeutic intervention study blocks ebola virus budding by regulating calcium signaling pnas plus klf negatively regulates estrogen induced epithelial cell proliferation by inhibition of dna replication licensing molecule found that inhibits estrogen key risk factor for endometrial and breast cancers in vivo suppression of hiv by antigen specific t cells derived from engineered hematopoietic stem cells engineered stem cells seek out and kill hiv in living mice international variation in female breast cancer incidence and mortality rates cancer epidemiol biomarkers breast cancer incidence death rates rising in some economically transitioning countries potential influences on the united kingdom s floods of winter potential influences on recent uk winter floods investigated by new scientific review premature mortality in epilepsy and the role of psychiatric comorbidity a total population study mental illness linked to early death in people with epilepsy contribution of company affiliation and social contacts to risk estimates of between farm transmission of avian influenza business affiliation could increase potential risk of farm to farm transmission of avian influenza coexistence with large carnivores supported by a predator compensation program reimbursing ranchers for livestock killed by predators supports conservation efforts reducing protected lands in a hotspot of bee biodiversity bees of grand staircase escalante national monument think about bees say researchers as grand staircase escalante national monument shrinks treatment of vitamin d insufficiency in postmenopausal women high dose vitamin d supplementation not associated with benefits for postmenopausal women mutations in aqp encoding a water channel protein cause autosomal dominant diffuse nonepidermolytic palmoplantar keratoderma scientists identify genetic cause of spongy skin condition what changes in the carbonate system oxygen and temperature portend for the northeastern pacific ocean a physiological perspective acidic oceans action plan to combat changes to seawater chemistry environmentally driven extinction and opportunistic origination explain fern diversification patterns fern fossil data clarifies origination and extinction of species childhood maltreatment and migraine part i. prevalence and adult revictimization a multicenter headache clinic survey abuse in childhood linked to migraine and other pain disorders krt lgr cells are radioresistant cancer initiating stem cells in the colon and intestine researchers identify new stem cell population important in the growth of colon cancer application of a breeding strategy to generate robust yeast starter cultures for cocoa pulp fermentations better chocolate with microbes same yeast used in beer wine and bread epidural spinal cord stimulation training and sustained recovery of cardiovascular function in individuals with chronic cervical spinal cord injury epidural stimulation leads to recovery of cardiovascular function in spinal cord injured in vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies leishmaniasis parasites evade death by exploiting immune response to sand fly bites origin of the heavy elements in binary neutron star mergers from a gravitational wave event astronomers strike cosmic gold confirm origin of precious metals in neutron star mergers detection of cancer antigens ca using gold nano particles on interdigitated electrode based microfluidic biosensor minute levels of disease detected with nanotechnology enhanced biochip eculizumab in aquaporin positive neuromyelitis optica spectrum disorder drug reduces risk of relapse with neuromyelitis optica do perceptual instructions lead to enhanced performance relative to behavioral instructions ? little known theory could hold key to sporting success multi contrast submillimetric tesla hippocampal subfield segmentation protocol and dataset micro map of hippocampus lends big hand to brain research universal characteristics of particle shape evolution by bed load chipping by river ocean or wind rocks round the same way long sightedness in old wild bonobos during grooming aging bonobos in the wild could use reading glasses too association between maternal gluten intake and type diabetes in offspring national prospective cohort study in denmark high gluten diet in pregnancy linked to increased risk of diabetes in children potential increase of legal deforestation in brazilian amazon after forest act revision large areas of the brazilian rainforest at risk of losing protection langerin negative dendritic cells promote potent cd t cell priming by skin delivery of live adenovirus vaccine microneedle arrays injection free vaccination technique could address global vaccine challenge for hiv malaria brain computer interface based communication in the completely locked in state brain computer interface allows completely locked in people to communicate advancing medical professionalism in us military detainee treatment a stronger ethical culture within the us military health care environment is needed experts urge. association of adding aspirin to warfarin therapy without an apparent indication with bleeding and other adverse events more than one third of patients risk major bleeding by doubling up on blood thinners socioeconomic inequality and peripheral artery disease prevalence in us adults socioeconomic status associated with peripheral artery disease risk obesity phenotypes in midlife and cognition in early old age the whitehall ii cohort study obesity metabolic factors linked to faster cognitive decline incidence and risk factors of venous thromboembolism in colorectal surgery does laparoscopy impart an advantage ? in colorectal surgery risk for blood clots appears higher with open method versus laparoscopy should prevention of falls start earlier ? co ordinated analyses of harmonised data on falls in middle aged adults across four population based cohort studies sharp increase in falls in women during midlife stair related injuries to young children treated in us emergency departments new study examines stair related injuries among children in the us received social support and exercising an intervention study to test the enabling hypothesis a new exercise partner is the key to exercising more higher gestational choline levels in maternal infection are protective for infant brain development expectant mothers can prevent fetal brain problems caused by the flu study shows global fe o isotope correlation reveals magmatic origin of kiruna type apatite iron oxide ores new research supports volcanic origin of kiruna type iron ores a peptide hormone required for casparian strip diffusion barrier formation in arabidopsis roots new peptide hormone aids waterproof barrier formation in plant roots antibiotics that target mitochondria effectively eradicate cancer stem cells across multiple tumor types treating cancer like an infectious disease antibiotics as new cancer treatments ? conversation with schoolgirl sparks idea efficient analysis of stochastic gene dynamics in the non adiabatic regime using piecewise deterministic markov processes novel computational biology model accurately describes dynamics of gene expression fecal microbiota transplant for treatment of clostridium difficile infection in immunocompromised patients safety of fecal transplant to treat c. difficile examined in study synthetic long read sequencing reveals intraspecies diversity in the human microbiome stunning diversity of gut bacteria uncovered by new approach to gene sequencing an atlas of genetic influences on osteoporosis in humans and mice a new atlas of genetic influences on osteoporosis gelatinous zooplankton biomass in the global oceans geographic variation and environmental drivers marine scientists create world s first global jellyfish database extreme alien light allows survival of terrestrial bacteria purple bacteria on earth could survive alien light artificial sweeteners reveal septic system effluent in rural groundwater artificial sweeteners in groundwater indicate contamination from septic systems copper bracelets and magnetic wrist straps for rheumatoid arthritis analgesic and anti inflammatory effects a randomised double blind placebo controlled crossover trial copper bracelets magnetic wrist straps fail to help rheumatoid arthritis tobacco smoking during radiation therapy for head and neck cancer is associated with unfavorable outcome smoking during radiation therapy for head and neck cancers linked to poorer outcomes macc a newly identified key regulator of hgf met signaling predicts colon cancer metastasis newly identified gene powerful predictor of colon cancer metastasis a computational model of a descending mechanosensory pathway involved in active tactile sensing modeling a nervous pathway involved in touch induced behavior a cell intrinsic inhibitor of hiv reverse transcription in cd t cells from elite controllers how protein blocks hiv life cycle in elite controllers solar rotational cycle in lightning activity in japan during the th centuries how does the sun s rotational cycle influence lightning activity on earth ? medicare formulary coverage restrictions for prescription opioids to few restrictions on prescription opioids through medicare study finds climate drives phenological reassembly of a mountain wildflower meadow community how climate change may reshape subalpine wildflower communities transcriptomics reveal transgenerational effects in purple sea urchin embryos adult acclimation to upwelling conditions alters the response of their progeny to differential pco levels biologists discover that female purple sea urchins prime their progeny to succeed in the face of stress combating transnational organized crime by linking multiple large ivory seizures to the same dealer dna tests of illegal ivory link multiple ivory shipments to same dealers overcrowding in psychiatric wards is associated with increased risk of adverse incidents overcrowding linked to violence and falls on psychiatric wards the recovery of north atlantic right whales eubalaena glacialis has been constrained by human caused mortality protecting adult female north atlantic right whales from injury and death key to recovery lung cancer incidence and the strength of municipal smoke free ordinances lower lung cancer rates in communities with strong smoke free laws study shows epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning epigenetic changes in twins of dieting mothers increases risk of obesity and diabetes epidural labor analgesia fentanyl dose and breastfeeding success early breastfeeding success not affected by epidural pain relief with fentanyl major trauma from suspected child abuse a profile of the patient pathway only one in five seriously injured child abuse victims treated at major trauma centers frequency of foxp cd cd t cells is associated with the phenotypes of allergic asthma frequency of t cells determines severity of asthma study finds high fat diet induced complement activation mediates intestinal inflammation and neoplasia independent of obesity fatty diet activates oldest branch of immune system causing intestinal tumors evidence for indirect effects of pain catastrophizing on clinical pain among myofascial temporomandibular disorder participants the mediating role of sleep disturbance change in attitude may ease chronic pain by aiding sleep study suggests causal associations between risk factors and common diseases inferred from gwas summary data scientists unleash power of genetic data to identify disease risk chemical antipredator defence is linked to higher extinction risk poisonous amphibian defenses are linked to higher extinction risk survival of patients with superficial esophageal adenocarcinoma after endoscopic treatment vs surgery less invasive option as effective as esophagus removal in early esophageal cancer habitat and species identity not diversity predict the extent of refuse consumption by urban arthropods insects play important role in dealing with garbage on nyc streets demography and metapopulation dynamics of an urban cooper s hawk subpopulation urban cooper s hawks outcompete their rural neighbors a hypothesis to reconcile the physical and chemical unfolding of proteins a tale of two roads into protein unfolding impaired h k methylation defines a subset of head and neck squamous cell carcinomas surprise advance in the treatment of adult cancers molecular composition of organic matter controls methylmercury formation in boreal lakes new study identifies organic matter composition as a critical factor controlling mercury methylation increased monocyte turnover from bone marrow correlates with severity of siv encephalitis and cd levels in plasma monocyte turnover predicts speed and severity of aids and onset of brain disease enhancing adaptive capacities in coastal communities through engaged communication research insights from a statewide study of shellfish co management small scale fisheries threatened shared management communication key to success pushing the limits two new species of pteromalus hymenoptera chalcidoidea pteromalidae from central europe with remarkable morphology twisted wasps two new unique parasitoid wasp species sting the heart of europe personalized machine learning for robot perception of affect and engagement in autism therapy personalized deep learning equips robots for autism therapy eccrine sweat glands are major contributors to reepithelialization of human wounds sweat glands play major role in healing human wounds effect of removal of planned parenthood from the texas women s health program study measures impact of removing planned parenthood from texas women s health program infection with transmissible strains of pseudomonas aeruginosa and clinical outcomes in adults with cystic fibrosis common strain of bacteria found in patients with cystic fibrosis in canada associated with greater risk of death electron transport chain remodeling by gsk during oogenesis connects nutrient state to reproduction to burn sugar or not to burn sugar how eggs store fuel for embryo development genome wide association study in brca mutation carriers identifies novel loci associated with breast and ovarian cancer risk new dna sequences home in on breast ovarian cancer risk global population dynamics and hot spots of response to climate change time series identify population responses to climate change screening for hiv associated tuberculosis and rifampicin resistance before antiretroviral therapy using the xpert mtb rif assay a prospective study new tuberculosis drug resistance test shows promise but needs investment for those diagnosed to be cured microenvironment induced pten loss by exosomal microrna primes brain metastasis outgrowth reversible tumor suppressor loss key to new brain cancer therapies ? neisseria gonorrhoeae infects the human endocervix by activating non muscle myosin ii mediated epithelial exfoliation gonorrhea manipulates an anti infection mechanism in the female reproductive tract information gain in the brain s resting state a new perspective on autism autistic brains create more information at rest study show postexposure protection of non human primates against a lethal ebola virus challenge with rna interference a proof of concept study experimental treatment protects monkeys from lethal ebola virus post exposure digital media and depressive symptoms among chinese adolescents a cross sectional study scientists find link between digital media use and depression in chinese adolescents metabolic profiling of high egg consumption and the associated lower risk of type diabetes in middle aged finnish men egg metabolites in blood related to lower risk of type diabetes rheological modification of liquid metal for additive manufacturing of stretchable electronics modified d printable alloy shows promise for flexible electronics soft robots musculoskeletal low back pain in school aged children low back pain in school aged children a common occurrence nanofibril scaffold assisted mems artificial hydrogel neuromasts for enhanced sensitivity flow sensing regulating iv infusion with innovative blind cave fish inspired sensor proton pump inhibitor use and risk of hip fractures among community dwelling persons with alzheimer s disease a nested case control study long term proton pump inhibitor use does not increase hip fracture risk among alzheimer s patients global outbreak of severe mycobacterium chimaera disease after cardiac surgery a molecular epidemiological study factory contamination of medical device likely source of m. chimaera infection in patients in multiple countries chemotherapy use and survival among young and middle aged patients with colon cancer overuse of chemotherapy among younger patients with colon cancer findings suggest mobile phone detection of atrial fibrillation with mechanocardiography the mode af study mobile phone detection of atrial fibrillation mobile application detecting atrial fibrillation reduces the risk of stroke systemic sclerosis is an independent risk factor of increased coronary artery calcium deposition systemic sclerosis is an independent risk factor for atherosclerosis study suggests huntington s disease ipsc derived brain microvascular endothelial cells reveal wnt mediated angiogenic and blood brain barrier deficits basis of leaky brain blood vessels in huntington s disease identified cranial vault thickness variation and inner structural organization in the stw hominin cranium from jacovec cavern south africa cranium of a four million year old hominin shows similarities to that of modern humans the potential of automatic word comparison for historical linguistics computational methods applied to big datasets are compelling tools for historical linguistics when procedures meet practice in community pharmacies qualitative insights from pharmacists and pharmacy support staff when reality bites procedures meet practice in community pharmacies early hearing detection and vocabulary of children with hearing loss babies with hearing loss form better vocabulary with early intervention explaining recent mortality trends among younger and middle aged white americans opioids and obesity not despair deaths raising mortality rates for white americans tau driven s proteasome impairment and cognitive dysfunction can be prevented early in disease by activating camp pka signaling improving brain s garbage disposal may slow alzheimer s other neurodegenerative diseases effect of vitamin d on asthma treatment failures in adults with symptomatic asthma and lower vitamin d levels limited benefit found for vitamin d in asthma treatment cd t help promotes influenza virus specific cd t cell memory by limiting metabolic dysfunction revealed how the iron man of immune cells helps t cells fight infection elevated hepatic dpp activity promotes insulin resistance and non alcoholic fatty liver disease enzyme produced in the liver promotes obesity fatty liver disease and insulin resistance the hyperglycemia and adverse pregnancy outcome study associations of gdm and obesity with pregnancy outcomes new pregnancy risk for babies and moms overweight moms with moderately high blood sugar raise health risk intensive hemodialysis associates with improved pregnancy outcomes a canadian and united states cohort comparison intensive dialysis in pregnant women with kidney failure provides benefits for mother baby temporal variation of human encounters and the number of locations in which they occur a longitudinal study of hong kong residents study of social contact patterns in hong kong will give insight into spread of epidemic washington state pediatricians attitudes toward alternative childhood immunization schedules washington pediatricians receive regular requests for alternative child immunization schedules harms and benefits of screening young people to prevent sudden cardiac death screening young athletes to prevent sudden cardiac arrest not proven to save lives wakefield s article linking mmr vaccine and autism was fraudulent british medical journal declares mmr study an elaborate fraud autism claims likened to piltdown man hoax preventing alcohol use with a voluntary after school program for middle school students results from a cluster randomized controlled trial of choice after school program can reduce alcohol use among middle school students study finds ubiquitous giant ly nebulae around the brightest quasars at z. revealed with muse unexpected giant glowing halos discovered around distant quasars defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency proteins on the loose in a rare childhood disease a reversible haploid mouse embryonic stem cell biobank resource for functional genomics haplobank a biobank of reversible mutant embryonic stem cells combined expectancies of alcohol and e cigarette use relate to higher alcohol use e cigarettes connected to problematic drinking study finds frequent sex protects intimates from the negative implications of their neuroticism frequent sex protects marital happiness for neurotic newlyweds evaluating the effects of the lunchtime enjoyment activity and play leap school playground intervention on children s quality of life enjoyment and participation in physical activity health benefits from free play confirmed by research cross sectional survey of salt content in cheese a major contributor to salt intake in the uk cheese still laden with salt despite many products meeting reduction targets loss of miro directed mitochondrial movement results in a novel murine model for neuron disease mitochondria s role in neurodegenerative diseases clearer thanks to mouse study nationwide expansion of a financial incentive program on fruit and vegetable purchases among supplemental nutrition assistance program participants a cost effectiveness analysis rebates a cost effective way to boost healthy eating among low income people study finds gingivae contain neural crest and mesoderm derived mesenchymal stem cells stem cells found in gum tissue can fight inflammatory disease persistent alteration in behavioural reactivity to a mild social stressor in rhesus monkeys repeatedly exposed to sevoflurane in infancy repeated anesthesia in infancy increases anxiety linked behavior in nonhuman primates amyloid disrupts human nrem slow waves and related hippocampus dependent memory consolidation poor sleep linked to toxic buildup of alzheimer s protein memory loss individual calling behaviour and movements of north atlantic minke whales balaenoptera acutorostrata passive acoustic monitoring reveals clues to minke whale calling behavior and movements oral contraceptive use is associated with prostate cancer an ecological study contraceptive pill associated with increased prostate cancer risk worldwide study finds the european association of preventive cardiology exercise prescription in everyday practice and rehabilitative training expert tool a digital training and decision support system for optimized exercise prescription in cardiovascular disease. concept personalized workouts to prevent heart disease designed by new digital instrument improved detection of candida albicans with carbon nanotube field effect transistors sexually transmitted infections transistors used to detect fungus candida albicans perceived benefits of fisheries management restrictions in madagascar malagasy fishers support fishing regulations despite economic challenges unexpected heterodivalent recruitment of nos ap to nnos reveals multiple sites for pharmacological intervention in neuronal disease models researchers discover new ways to shut down signals involved in brain diseases evolution of plant pollinator mutualisms in response to climate change biodiversity can promote survival on a warming planet mathematical model shows collapse of a desert bird community over the past century driven by climate change mojave desert birds crashed over the last century due to climate change wnt signaling regulates proliferation and differentiation of radial glia in regenerative processes after stab injury in the optic tectum of adult zebrafish stab injury of zebrafish unveils regenerative processes by neural stem cells in the brain non trophic interactions in deserts facilitation interference and an endangered lizard species scat sniffer dogs tell researchers a lot about endangered lizards adolescents misperceive and are influenced by high status peers health risk deviant and adaptive behavior. misfit or miss goody two shoes ? adolescent misperceptions abound drosophila slc a transporter is a memory suppressor gene that influences cholinergic neurotransmission to the mushroom bodies memory suppressor gene could hold key to new alzheimer s disease treatments cdk interacts with sox and promotes tumor initiation in human melanoma cancer stem cells use normal genes in abnormal ways one step reforming of co and ch into high value liquid chemicals and fuels at room temperature by plasma driven catalysis breakthrough in direct activation of co and ch into liquid fuels and chemicals global human appropriation of net primary production doubled in the th century the intensity of land use doubled in the th century directed conversion of alzheimer s disease patient skin fibroblasts into functional neurons bypassing stem cells scientists make neurons directly from human skin influenza a virus alters pneumococcal nasal colonization and middle ear infection independently of phase variation influenza a potentiates pneumococcal co infection new details emerge clinical relevance of thrombocytosis in primary care a prospective cohort study of cancer incidence using english electronic medical records and cancer registry data raised blood platelet levels strong predictor of cancer childhood trajectories of peer victimization and prediction of mental health outcomes in midadolescence a longitudinal population based study teens who were severely bullied as children at higher risk of suicidal thoughts mental health issue the level and nature of autistic intelligence ii what about asperger syndrome ? level and nature of autistic intelligence what about asperger syndrome ? meltwater produced by wind albedo interaction stored in an east antarctic ice shelf mysterious crater on antarctica indication of vulnerable ice sheet neuromelanin sensitive mri as a non invasive proxy measure of dopamine function in the human brain neuromelanin sensitive mri identified as a potential biomarker for psychosis turning the fate of reprogramming cells from retinal disorder to regeneration by pax in newts role identified for key protein in regeneration of damaged newt retinas longitudinal associations of childhood bedtime and sleep routines with adolescent body mass index regular bedtimes and sufficient sleep for children may lead to healthier teens ccctc binding factor acts as a heterochromatin barrier on herpes simplex viral latent chromatin and contributes to poised latent infection viral hideout after infection herpes lurks in nerve cells the ecology of microscopic life in household dust home sweet microbe dust in your house can predict geographic region gender of occupants castor is required for hedgehog dependent cell fate specification and follicle stem cell maintenance in drosophila oogenesis scientist identifies protein molecule used to maintain adult stem cells in fruit flies effect of helmet use on traumatic brain injuries and other head injuries in alpine sport increased helmet use in alpine sports fails to reduce risk of traumatic brain injury mw inhibited il levels after traumatic brain injury with no effect on microglia physiological responses experimental drug may limit harmful effects of traumatic brain injury social dominance alters nutrition related gene expression immediately transcriptomic evidence from a monomorphic queenless ant robbed of royalty mutilation and social determination of female diacamma ants at school victimization and violence exposure assessed in a national household survey of children and youth research highlights extent effects of school violence in u.s. oh vitamin d inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type diabetes mellitus why low vitamin d raises heart disease risks in diabetics quantifying tidally driven benthic oxygen exchange across permeable sediments an aquatic eddy correlation study breathing sand new measurement technique detects oxygen supply to bottom of north sea structural basis for targeting avian sarcoma virus gag polyprotein to the plasma membrane for virus assembly uncovering a key mechanism in assembly of avian sarcoma virus a relative of hiv perinatal outcomes by mode of assisted conception and sub fertility in an australian data linkage cohort higher risk of birth problems after assisted conception use of e cigarettes by individuals with mental health conditions e cigarettes and mental health people with depression axiety more likely to try e cigarettes concern about early intraprosthetic dislocation in dual mobility implants concerns with intraprosthetic dislocation of dual mobility hip implants maternal imprinting at the h igf locus maintains adult haematopoietic stem cell quiescence genomic imprinting maintains a reserve pool of blood forming stem cells in mouse bone marrow dendrogenin a a mammalian metabolite of cholesterol with tumor suppressor and neurostimulating properties from tamoxifen to dendrogenin a discovery of a mammalian tumor suppressor metabolite assessing ict global emissions footprint trends to recommendations smartphones and data centers harm the environment study shows coral bleaching response index a new tool to standardize and compare susceptibility to thermal bleaching using data to protect coral reefs from climate change kratom exposures reported to united states poison control centers study finds increase in calls to us poison control centers for kratom exposure leatherback turtle movements dive behavior and habitat characteristics in ecoregions of the northwest atlantic ocean tracking endangered leatherback sea turtles by satellite key habitats identified stable isotope and trace element studies on gladiators and contemporary romans from ephesus turkey nd and rd ct. ad implications for differences in diet roman gladiators ate a mostly vegetarian diet and drank a tonic of ashes after training mutations in pmpcb encoding the catalytic subunit of the mitochondrial presequence protease cause neurodegeneration in early childhood in a severe childhood neurodegeneration novel mechanism found chromosomal instability during neurogenesis in huntington s disease uncovering the early origins of huntington s disease direct fed microbial supplementation repartitions host energy to the immune system feeding microbials to chickens leads to mysterious immune response methods in plant foliar volatile organic compounds research de mystifying the study of volatile organic plant compounds high kellgren lawrence grade and bone marrow lesions predict worsening rates of radiographic joint space narrowing the sekoia study bone marrow lesions can help predict rapidly progressing joint disease synchrotron based chemical imaging reveals plumage patterns in a million year old early bird x rays reveal new picture of dinobird plumage patterns folic acid fortification and prevalences of neural tube defects orofacial clefts and gastroschisis in california to less decline than expected in brain spine defects after folic acid fortification program small molecule ion channels increase host defences in cystic fibrosis airway epithelia potential cystic fibrosis treatment uses molecular prosthetic for missing lung protein disparity in melanoma a trend analysis of melanoma incidence and stage at diagnosis among whites hispanics and blacks in florida trends in melanoma incidence and stage at diagnosis vary by racial and ethnic group long term survival of influenza virus infected club cells drives immunopathology club cells are bad guys during flu infection low eosinophils during bronchiolitis in infancy are associated with lower risk of adulthood asthma early childhood bronchiolitis increases asthma risk in adulthood freedom of information lessons from india collaboration co production and rights based agenda building india s right to information act provides lessons on government transparency crystal structure of the human sterol transporter abcg abcg researchers determine d atomic structure of cholesterol transporter impact of modular organization on dynamical richness in cortical networks precision neuroengineering enables reproduction of complex brain like functions in vitro desymmetrization of cyclohexanes by site and stereoselective c h functionalization chemical catalyst turns trash into treasure making inert c h bonds reactive understanding the role of selenium in defect passivation for highly efficient selenium alloyed cadmium telluride solar cells researchers gain key insight into solar material s soaring efficiency lis regulates asymmetric division in hematopoietic stem cells and in leukemia split decision stem cell signal linked with cancer growth coherent injection locking of quantum cascade laser frequency combs novel laser technology for microchip size chemical sensors genome wide crispr screens for shiga toxins and ricin reveal golgi proteins critical for glycosylation new light on blocking shiga and ricin toxins and on an iconic biological process sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology researchers id key drivers of heart complications in sickle cell anemia the unintended consequences of countermarketing strategies how particular antismoking measures may shift consumers to more dangerous cigarettes increasing cigarette taxes shifts consumers to more dangerous products european society of endocrinology clinical guideline on treatment of chronic hypoparathyroidism in adults new guideline puts emphasis on patient care in treating hypoparathyroidism estradiol increases the sensitivity of ventral tegmental area dopamine neurons to dopamine and ethanol higher estrogen levels linked to increased alcohol sensitivity in brain s reward center barriers to access to visceral leishmaniasis diagnosis and care among seasonal mobile workers in western tigray northern ethiopia a qualitative study mobile workers in north ethiopia vulnerable to visceral leishmaniasis transmission apoptotic caspases regulate induction of ipscs from human fibroblasts mechanism for changing adult cells into stem like cells discovered climate change and psychology effects of rapid global warming on violence and aggression climate change increases potential for conflict and violence mir p potentiates vincristine and radiation response by inducing spindle defects and dna damage in medulloblastoma tiny molecule has big effect in childhood brain tumor studies fault architecture basin structure and evolution of the gulf of corinth rift central greece formation of the gulf of corinth rift greece how small is the smallest ? new record and remeasuring of scydosella musawasensis hall coleoptera ptiliidae the smallest known free living insect how small is the smallest ? new record of the tiniest free living insect provides precision combining a kindergarten readiness summer program with a self regulation intervention improves school readiness intervention offered in school readiness program boosts children s self regulation skills exclusive enteral nutrition provides an effective bridge to safer interval elective surgery for adults with crohn s disease pre operative liquid feeding reduces complications following crohn s disease surgery a comprehensive review of assay methods to determine drugs in breast milk and the safety of breastfeeding when taking drugs breast milk transmits drugs and medicines to the baby reconstructing the microbial diversity and function of pre agricultural tallgrass prairie soils in the united states first look at diverse life below rare tallgrass prairies impact of state ignition interlock laws on alcohol involved crash deaths in the united states in car breathalyzers for dui offenders curb drunk driving deaths by percent associations between high risk alcohol consumption and sarcopenia among postmenopausal women higher alcohol consumption leads to greater loss of muscle tissue in postmenopausal women predicting neurodevelopmental outcomes at preschool age for children with very low birth weight four factors predict neurodevelopmental outcomes for children with low birth weight improving the forecast for biodiversity under climate change improving predictions of the effects of climate change on ecosystems transcript protein and metabolite temporal dynamics in the cam plant agave new study of water saving plants advances efforts to develop drought resistant crops development and validation of kasp markers for the greenbug resistance gene gb and the hessian fly resistance gene h in wheat genetic discovery another tool in battle against wheat pests transcription signaling and metabolic transitions during human spermatogonial stem cell differentiation new research on sperm stem cells has implications for male infertility and cancer seeing central african forests through their largest trees developing models for predicting carbon levels in central african forests based on measuring only of all trees live imaging of neurogenesis in the adult mouse hippocampus stem cell divisions in the adult brain seen for the first time acute exacerbations and lung function loss in smokers with and without copd copd exacerbations lead to lung function decline particularly among those with mild copd multivalent ligand displayed on plant virus induces rapid onset of bone differentiation speeding up bone growth by manipulating stem cells hypertensive disorders in pregnancy and the risk of subsequent cardiovascular disease hypertension during pregnancy may affect women s long term cardiovascular health a new species of oeneis from alaska united states with notes on the oeneis chryxus complex lepidoptera nymphalidae satyrinae is alaska s first new butterfly species in decades an ancient hybrid ? multicenter study of repeat epinephrine treatments for food related anaphylaxis children with food allergies should carry two doses of emergency medicine experts urge details of a thallium poisoning case revealed by single hair analysis using laser ablation inductively coupled plasma mass spectrometry mass spectrometry sheds new light on thallium poisoning cold case thirty year mortality after coronary artery bypass graft surgery many good years after heart bypass surgery but something happens after ten years the acute mania of king george iii a computational linguistic analysis analysis of letters written by mad king george iii supports psychiatric diagnosis of mania a single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children bait knocks out cockroaches and asthma symptom days online patient provider e cigarette consultations perceptions of safety and harm physician advice to patients on e cigarettes varies reveals knowledge gaps study shows complement c a receptor is the key initiator of neutrophil adhesion igniting immune complex induced arthritis tracking movement of immune cells identifies key first steps in inflammatory arthritis opioid substitution therapy time to replace the term local physician recommends world health organization retire the term opioid substitution therapy direct measurements of meltwater runoff on the greenland ice sheet surface extreme fieldwork climate modeling yields new insight into predicting greenland s melt further neuroimaging evidence for the deficit subtype of schizophrenia a cortical connectomics analysis brain networks differ among those with severe schizophrenia study shows dpp inhibition attenuates cardiac dysfunction and adverse remodeling following myocardial infarction in rats with experimental diabetes new way to treat chronic kidney disease and heart failure statins and intracerebral hemorrhage a retrospective cohort study study finds no link between intracerebral hemorrhage and statin use among patients with prior stroke geographic variation in receipt of psychotherapy in children receiving attention deficit hyperactivity disorder medications few kids receive psychotherapy along with medication for adhd study finds a first principles study of pristine and al doped activated carbon interacting with fluorouracil anticancer drug better chemo drug adsorption onto targeted delivery capsules astrocytes promote glioma invasion via the gap junction protein connexin target healthy cells to stop brain cancer hijack will tropical mountaintop plant species survive climate change ? identifying key knowledge gaps using species distribution modelling in australia high altitude climate change to kill cloud forest plants rescuing z agrin splicing in nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing rna master regulator of motor neuron firing discovered detecting infections rapidly and easily for candidemia trial part direct a prospective multicenter study of the t candida panel blood test cuts time to diagnosis for common deadly yeast infection national trial shows antibiotic management of urinary tract infection in elderly patients in primary care and its association with bloodstream infections and all cause mortality population based cohort study early use of antibiotics in elderly patients with utis associated with reduced risk of sepsis brain responses to biological motion predict treatment outcome in young children with autism two new tools to enhance effectiveness of behavioral therapy in children with autism epidemiology and outcomes of people with dementia delirium and unspecified cognitive impairment in the general hospital prospective cohort study of admissions hospital patients with dementia and other causes of confusion have worse outcomes evasion of immunosurveillance by genomic alterations of ppar rxr in bladder cancer immune cells the missing ingredient in new bladder cancer treatment sensory feedback reduces individuality by increasing variability within subjects sensory feedback shapes individuality to provide equal space for behavioral excellence racial bias in pain assessment and treatment recommendations and false beliefs about biological differences between blacks and whites study links disparities in pain management to racial bias the eurasian invasion phylogenomic data reveal multiple southeast asian origins for indian dragon lizards land bridges linking ancient india eurasia were freeways for biodiversity exchange circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition transition in cell type parallels treatment response disease progression in breast cancer crebbp loss drives small cell lung cancer and increases sensitivity to hdac inhibition big picture approach to understanding cancer will speed new treatments demographic histories isolation and social factors as determinants of the genetic structure of alpine linguistic groups effects of migrations closed holdings on dna of alpine peoples d printed earable smart devices for real time detection of core body temperature personalized earable sensor monitors body temperature in real time use of moist smokeless tobacco snus and the risk of development of alcohol dependence a cohort study in a middle aged population in sweden using snus doubles the risk of alcohol dependency neural modularity helps organisms evolve to learn new skills without forgetting old skills modular brains help organisms learn new skills without forgetting old skills forty years of work on end of life care from patients rights to systemic reform improving end of life care lessons from years of work global scale evidence for the refractory nature of riverine black carbon charcoal major missing piece in the global carbon cycle association between childhood migraine and history of infantile colic migraines in childhood and adolescence associated with having colic as an infant sry negative xx sex reversal in a french bulldog first french bulldog with sex reversal identified in spain volumetric ca imaging in the mouse brain using hybrid multiplexed sculpted light microscopy new microscopy technique peers deep into the brain neuromolecular responses to social challenge common mechanisms across mouse stickleback fish and honey bee different species share genetic toolkit for behavioral traits antecedent predictors of children s initiation of sipping tasting alcohol young children s sipping tasting of alcohol reflects parental modeling a glucose fuel cell for implantable brain machine interfaces new energy source for future medical implants sugar variations in brain defects result from cellular mosaicism in the activation of heat shock signalling drinking in pregnancy excess transcription factor heat shock factor can delay embryonic neural migration elevated foxg and sox in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators brain cancer discovery reveals clues in quest for new therapies imaging and monitoring of the shallow subsurface using spatially windowed surface wave analysis with a single permanent seismic source new approach offers high resolution seismic monitoring of the shallow subsurface unmasking the conflicting trends in job tenure by gender in the united states divergent u.s. job tenure patterns greater job continuity for married moms masks general trend toward shorter term employment gender dimorphism of brain reward system volumes in alcoholism effects of alcoholism on the brain s reward system may be different in women than in men clinical usage and economic effectiveness of a recently developed epidermal autograft harvesting system in chronic wound patients in a university based wound center new skin graft system a better fix for chronic wounds long term oral bisphosphonate use in relation to fracture risk in postmenopausal women with breast cancer link between early menopause higher risk of fracture new study confirms disruption of astrocyte vascular coupling and the blood brain barrier by invading glioma cells brain tumor cells move damage tissue research points to possible therapy mothers of obese children use more direct imperatives to restrict eating moms of obese children use different words to restrict eating fibronectin rescues estrogen receptor from lysosomal degradation in breast cancer cells breast cancer growth signals are enhanced by a protein outside cells effect of low perceived social support on health outcomes in young patients with acute myocardial infarction results from the virgo variation in recovery role of gender on outcomes of young ami patients study low social support linked to poor health in young heart attack survivors parallel sites implicate functional convergence of the hearing gene prestin among echolocating mammals for bats and dolphins hearing gene prestin adapted for echolocation environmentally mediated consumer control of algal proliferation in florida springs algae eating native freshwater snails little janitor merits attention in florida springs health debate direct evidence of milk consumption from ancient human dental calculus ancient dental plaque a whey into our milk drinking past ? global models underestimate large decadal declining and rising water storage trends relative to grace satellite data discrepancies between satellite and global model estimates of land water storage effectiveness of a dental care intervention in the prevention of lower respiratory tract nosocomial infections among intensive care patients a randomized clinical trial proper dental care linked to reduced risk of respiratory infections in icu patients structural basis for anthrax toxin receptor recognition by seneca valley virus anti cancer virus fits tumor receptor like a key in a lock suppression of transcription factor early growth response reduces herpes simplex virus lethality in mice virology how does herpes simplex virus cause inflammation of the brain ? roles of diffusion dynamics in stem cell signaling and three dimensional tissue development diffusion dynamics play an essential role in regulating stem cells and tissue development enhanced therapeutic and long term dynamic vascularization effects of human pluripotent stem cell derived endothelial cells encapsulated in a nanomatrix gel long lasting blood vessel repair in animals via stem cells a randomized trial directly comparing ventral capsule and anteromedial subthalamic nucleus stimulation in obsessive compulsive disorder clinical and imaging evidence for dissociable effects deep brain stimulation sites for ocd target distinct symptoms giant worms chez moi ! hammerhead flatworms platyhelminthes geoplanidae bipalium spp. diversibipalium spp. in metropolitan france and overseas french territories giant invasive flatworms found in france and overseas french territories so excellent a fishe a global overview of legal marine turtle fisheries legal harvest of marine turtles tops each year sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of huntington s disease scientists coax brain to regenerate cells lost in huntington s disease in mouse model a new species of puddle frog from an unexplored mountain in southwestern ethiopia anura phrynobatrachidae phrynobatrachus new frog species found on remote ethiopian mountain fibroblast growth factor is associated with axonal integrity and neural network architecture in the human frontal lobes the hormone fgf is linked to structural deficits in the brain factors that determine catastrophic expenditure for tuberculosis care a patient survey in china better healthcare could reduce crippling personal costs of tuberculosis care in china the role of firm low carbon electricity resources in deep decarbonization of power generation adding power choices reduces cost and risk of carbon free electricity bottom side roll feeding by humpback whales megaptera novaeangliae in the southern gulf of maine u.s.a research reveals bottom feeding techniques of tagged humpback whales in stellwagen bank sanctuary sex race and consideration of bariatric surgery among primary care patients with moderate to severe obesity researcher looks at link between race bariatric surgery vietnamese mothers experiences with potty training procedure for children from birth to years of age whistle away the need for diapers vietnamese babies often out of diapers at nine months loss of caveolin in prostate cancer stroma correlates with reduced relapse free survival and is functionally relevant to tumor progression new study on popular prostate cancer protein provides insight into disease progression prmt pten molecular pathway regulates senescence and self renewal of primary glioblastoma neurosphere cells blocking prmt might force resistant brain tumor cells into senescence study suggests infants advances in speech perception shape their earliest links between language and cognition infants advances in speech processing play role in language cognition link impact of hiv co infection on the evolution and transmission of multidrug resistant tuberculosis hiv not a super spreader of drug resistant tuberculosis biogeography and demography of an australian native bee ceratina australensis hymenoptera apidae since the last glacial maximum bee populations expanded during global warming after the last ice age the potential for school based interventions that target executive function to improve academic achievement a review little evidence that executive function interventions boost student achievement the allelic landscape of human blood cell trait variation and links to common complex disease landmark project shows heart disease rheumatoid arthritis risk raised by genetic changes in blood cells reward probability and timing uncertainty alter the effect of dorsal raphe serotonin neurons on patience wait for it serotonin and confidence at the root of patience in new study the prevalence of age related macular degeneration and associated risk factors early stages of age related macular degeneration associated with smoking cholesterol levels human induced global ocean warming on multidecadal timescales humans are primary cause of global ocean warming over past years research shows bliss and loewe interaction analyses of clinically relevant drug combinations in human colon cancer cell lines reveal complex patterns of synergy and antagonism novel open source software for drug combination analysis reveals complex effects of combining clinically used drugs dynamical basis for drug resistance of hiv protease drug designer new tool reveals mutations that cause hiv drug resistance wild bee diversity increases with local fire severity in a fire prone landscape wild bees flock to forested areas affected by severe fire d tooth microwear texture analysis in fishes as a test of dietary hypotheses of durophagy a fishy tale of a sheep in wolf s clothing carbon budgets for. and c targets lowered by natural wetland and permafrost feedbacks what natural greenhouse gases from wetlands and permafrosts mean for paris agreement goals estimates of burden and consequences of infants born small for gestational age in low and middle income countries with intergrowth ststandard analysis of cherg datasets population health impact of infants born small for gestational age in low and middle income countries in vivo reprogramming of wound resident cells generates skin epithelial tissue the alchemy of healing researchers turn open wounds into skin membrane impermeable cross linking provides evidence for homophilic isoform specific binding of desmosomal cadherins in epithelial cells cell binding discovery brings hope to those with skin and heart problems a new cretaceous dercetid fish neoteleostei aulopiformes from the turonian of colombia child aids paleontologists in discovery of new ancient fish species vigorous lateral export of the meltwater outflow from beneath an antarctic ice shelf scientists unravel the process of meltwater in ocean depths physical activity behavior predicts endogenous pain modulation in older adults can staying active help to prevent chronic pain ? physical activity affects pain modulation in older adults the eldgj eruption timing long range impacts and influence on the christianisation of iceland volcanic eruption influenced iceland s conversion to christianity school grades parental education and suicide a national register based cohort study poor school grades linked to increased suicide risk swedish study reveals synthetic lxr agonist attenuates plaque formation in apoe mice without inducing liver steatosis and hypertriglyceridemia potential atherosclerosis drug exhibits no harmful side effects in liver phase iii trial of weekly methotrexate or pulsed dactinomycin for low risk gestational trophoblastic neoplasia a gynecologic oncology group study gynecologic cancer expert helps pinpoint best treatment for fast growing gestational tumors sodium excretion and the risk of cardiovascular disease in patients with chronic kidney disease higher salt intake may increase risk of cardiovascular disease among patients with chronic kidney disease snapshots of a modified nucleotide moving through the confines of a dna polymerase new insights into dna polymerases in interaction with modified substrates extracting storm surge data from coastal dunes for improved assessment of flood risk luminous grains of sand determine year of historic storm flood dutch researchers find experimental malaria in pregnancy induces neurocognitive injury in uninfected offspring via a c a c a receptor dependent pathway maternal malaria during pregnancy causes cognitive defects in the offspring interleukin deficiency causes tau abnormality and neurodegeneration with alzheimer like symptoms in aged mice brain s response to mid life surge in cell aging starts or ends a path to dementia common dietary patterns and risk of cancers of the colon and rectum analysis from the united kingdom women s cohort study ukwcs links between eating red meat and distal colon cancer in women the effect of body mass index on pelvic floor support year postpartum high post pregnancy bmi raises pelvic organ prolapse risk enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody induced severe dengue disease vaccine possible hypothesis on the mystery of dengue virus infection confirmed computations underlying social hierarchy learning distinct neural mechanisms for updating and representing self relevant information knowing one s place in a social hierarchy tfiih kinase places bivalent marks on the carboxy terminal domain of rna polymerase ii new piece found in the puzzle of epigenetics mechanism of fine regulation of rna synthesis elucidated mmtx and mmtx from coral snake venom potently modulate gabaa receptor activity coral snake venom reveals a unique route to lethality interactive associations of vascular risk and amyloid burden with cognitive decline in clinically normal elderly individualsfindings from the harvard aging brain study vascular risk interacts with amyloid levels to increase age related cognitive decline temperature triggered collection and release of water from fogs by a sponge like cotton fabric cotton with special coating collects water from fogs in desert time trends in the prevalence of celiac disease and gluten free diet in the us population results from the national health and nutrition examination surveys prevalence of celiac appears steady but followers of gluten free diet increase drivers of temporal changes in temperate forest plant diversity vary across spatial scales drivers of temporal changes in temperate forest plant diversity largest global shark biomass found in the northern gal pagos islands of darwin and wolf northern galapagos islands home to world s largest shark biomass cost effectiveness of a motivational intervention to reduce rapid repeated childbearing in high risk adolescent mothers a rebirth of economic and policy considerations intervention appears cost effective for preventing repeated teenage births the population genomics of archaeological transition in west iberia investigation of ancient substructure using imputation and haplotype based methods bronze age iberia received fewer steppe invaders than the rest of europe beaming into the rat world enabling real time interaction between rat and human each at their own scale virtual reality puts human in rat world beaming technology transforms human animal interaction influenza vaccination in adolescents with high risk conditions flu vaccination rates lag for at risk adolescents twenty first century glacier slowdown driven by mass loss in high mountain asia asian glaciers slowed by ice loss nasa finds early detection of new melanomas by patients with melanoma and their partners using a structured skin self examination skills training intervention partners of patients with melanoma find new cancers with skin exam training current office based hearing screening questions fail to identify adolescents at risk for hearing loss screening questions fail to identify teens at risk for hearing loss neurodevelopmental disorders and prenatal residential proximity to agricultural pesticides the charge study association found between maternal exposure to agricultural pesticides and autism nanochannel implants for minimally invasive insertion and intratumoral delivery new minimally invasive device to treat cancer and other illnesses risk of adverse outcomes among infants of immigrant women according to birth weight curves tailored to maternal world region of origin birthweight charts tailored to specific ethnic groups may be better predictor of adverse outcomes fire derived charcoal might promote fine root decomposition in boreal forests charcoal remains could accelerate co emissions after forest fires whole blood gene expression profiles to assess pathogenesis and disease severity in infants with respiratory syncytial virus infection genetic signature identified for leading cause of infant hospitalizations worldwide blue whale population structure along the eastern south pacific ocean evidence of more than one population study on world s biggest animal finds more than one population in the southeastern pacific gut bacteria metabolism impacts immune recovery in hiv infected individuals gut bacteria affect immune recovery in hiv patients study finds racial differences in follow up of abnormal mammography findings among economically disadvantaged women study finds delay in follow up among african american women receiving abnormal breast finding x ray fluorescence imaging and other analyses identify selenium and gpx as important in female reproductive function women s fertility linked to detox element in diet genetic interactions between the aurora kinases reveal new requirements for aurkb and aurkc during oocyte meiosis three proteins may play key roles in female fertility and cancer biology healthy lifestyle interventions to combat noncommunicable disease a novel nonhierarchical connectivity model for key stakeholders a policy statement from the american heart association european society of cardiology european association for cardi experts call for all hands on deck to tackle global burden of non communicable disease source characteristics of the haida gwaii earthquake sequence new research complicates seismic hazard for british columbia alaska region alcohol intake and breast cancer risk in african american women from the amber consortium alcohol is associated with higher risk of breast cancer in african american women sox links tumor suppression to accelerated aging in mice by modulating stem cell activation gene that links stem cells aging cancer discovered by researchers a case study on trade in threatened tiger geckos goniurosaurus in vietnam including updated information on the abundance of the endangered g. catbaensis tiger geckos in vietnam could be the next species sold into extinction national priorities for dementia care perspectives of persons living with dementia and their care partners dementia patients caregivers prefer better care support over research for alzheimer s cure a patient follow up program for short term surgical mission trips to a developing country ensuring ongoing care for patients treated during short term surgical mission trips biotransformation of p xylene into terephthalic acid by engineered escherichia coli bio based p xylene oxidation into terephthalic acid by engineered e. coli wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes active wound healing can accelerate tumor formation study finds lower liver related death in african american women with human immunodeficiency virus hepatitis c virus coinfection compared to caucasian and hispanic women african american women with hiv hcv less likely to die from liver disease pathological complete response after neoadjuvant chemotherapy is an independent predictive factor irrespective of simplified breast cancer intrinsic subtypes a landmark and two step approach analyses from the eortc big phase iii trial pathological complete response predictor of favorable breast cancer outcome acute pectoralis major tears in forward deployed active duty u.s. military personnel a population at risk ? military surgeons report alarming frequency of bench press injuries a meta analysis of the relations between three types of peer norms and adolescent sexual behavior. personality and social psychology review. a meta analysis of three types of peer norms and their relation with adolescent sexual behavior vascular progenitors from cord blood derived ipsc possess augmented capacity for regenerating ischemic retinal vasculature lab grown virus free stem cells repair retinal tissue in mice physicians experiences with male patients who perpetrate intimate partner violence physicians not prepared for male patients who perpetrate intimate partner violence distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo researchers map out the atlas of gene regulators in human cardiac cells for the first time dehydration of lawsonite could directly trigger earthquakes in subducting oceanic crust research may explain mysterious deep earthquakes in subduction zones instagram flickr or twitter assessing the usability of social media data for visitor monitoring in protected areas visitor patterns and emerging activities in finish national parks revealed by social media posts noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma dna new technique could expand number of diseases detected by noninvasive prenatal testing identifying effective actions to guide volunteer based and nation wide conservation efforts for a ground nesting farmland bird public raises alarm about ineffectiveness of some montagu s harrier conservation measures molecular evolution of early onset prostate cancer identifies molecular risk markers and clinical trajectories prostate cancer new computer model enables researchers to predict course of disease do weather fluctuations cause people to seek information about climate change ? what do google searches tell us about our climate change fears ? vaccine against muc antigen expressed in inflammatory bowel disease and cancer lessens colonic inflammation and prevents progression to colitis associated colon cancer vaccine could delay bowel inflammation and colon cancer the evolution of epigenetics from prokaryotes to humans and its biological consequences how epigenetics regulate vital functions from bacteria to humans molecularnetworks an integrated graph theoretic and data mining tool to explore solvent organization in molecular simulation chemist applies google software to webs of the molecular world relationships between unit cell parameters and composition for rock forming minerals on earth mars and other extraterrestrial bodies new data mining technique offers most vivid picture of martian mineralogy major adverse limb events and wound healing following infrapopliteal artery stent implantation in patients with critical limb ischemia the xcell trial new angioplasty procedure improves blood flow in blocked arteries to extremities a comparison of the effects of types of massage and usual care on chronic low back pain a randomized controlled trial massage eases low back pain in randomized controlled trial exposure to electronic cigarettes impairs pulmonary anti bacterial and anti viral defenses in a mouse model e cigarette exposure impairs immune responses in mouse model quantitative monitoring of lipid accumulation over time in cultured adipocytes as function of culture conditions toward controlled adipose tissue engineering a lab rat created in the lab bioengineering tissues as an alternative to animal testing fingering instabilities and pattern formation in a two component dipolar bose einstein condensate frogs and mushrooms bubble up in quantum fluids expansion of oxygen minimum zones may reduce available habitat for tropical pelagic fishes expanding dead zones are shrinking tropical blue marlin habitat cognitive behavioral therapy for child anxiety confers long term protection from suicidality successful cognitive behavioral therapy in youth leads to decreased thinking about suicide genetic modifiers of the brd nut dependency of nut midline carcinoma uncovers a synergism between betis and cdk is study of rare cancer yields therapeutic clues to combat drug resistance lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells study solves ovarian cell mystery shedding new light on reproductive disorders wild pollinators enhance fruit set of crops regardless of honey bee abundance loss of wild insects hurts crops around the world pick deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance researchers discover new explanation for diabetes and poor growth nestin and dcx positive cells reside in adult spinal cord meninges and participate to injury induced parenchymal reaction new evidence for spinal membrane as a source of stem cells may advance treatment of spinal cord injuries physical maturity and concussion symptom duration among adolescent ice hockey players less physically mature ice hockey players have prolonged concussion symptoms quality of health insurance coverage and access to care for children in low income families kids with medicaid chip get more preventive care than those with private insurance estrogen regulates bone turnover by targeting rankl expression in bone lining cells estrogen regulates pathological changes of bones via bone lining cells decreasing transition times in elementary school classrooms using computer assisted instruction to automate intervention components new system helps teachers gain back valuable instruction time temporal trends in the associations between age sex and socioeconomic status after death from motor vehicle collisions in england and wales annual car crash deaths in england wales have fallen percent in years peak blood pressure responses during maximum cardiopulmonary exercise testingnovelty and significance what is a normal blood pressure response during exercise testing ? future effects of climate and land use change on terrestrial vertebrate community diversity under different scenarios climate change to overtake land use as major threat to global biodiversity anti tnf drives regulatory t cell expansion by paradoxically promoting membrane tnf tnf rii bindin g in rheumatoid arthritis new mode of action for humira in rheumatoid arthritis patients characteristics complications and gaps in evidence based interventions in rheumatic heart disease the global rheumatic heart disease registry the remedy study utter neglect of rheumatic heart disease revealed by results from global study obligatory role of hypothalamic neuroestradiol during the estrogen induced lh surge in female ovariectomized rhesus monkeys estrogen discovery could shed new light on fertility problems reward type and performance an examination of organizational wellness programs gift card incentives connected to healthier outcomes in employee wellness programs folic acid and risk of prostate cancer results from a randomized clinical trial folic acid supplements linked to higher risk of prostate cancer study shows intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged years lowering blood pressure reduces risk of heart disease in older adults review the impacts of circulating hydroxyvitamin d levels on cancer patient outcomes a systematic review and meta analysis vitamin d may raise survival rates among cancer patients a yellow fever epidemic a new global health emergency ? yellow fever epidemic new global health emergency ? recent hepatitis c virus testing patterns among baby boomers testing for hepatitis c virus remains low among baby boomers fibril formation and therapeutic targeting of amyloid like structures in a yeast model of adenine accumulation new yeast model of metabolic disorders may lead to life saving therapies farnesoid x receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo new route for development of anti diarrhea drugs the pho signaling pathway directs lipid remodeling in cryptococcus neoformans via dgts synthase to recycle phosphate during phosphate deficiency new research uncovers how life threatening fungal diseases adapt to survive in humans plasma profiling reveals three proteins associated to amyotrophic lateral sclerosis potential for als treatment found in three proteins aldehyde dehydrogenase expression drives human regulatory t cell resistance to posttransplantation cyclophosphamide how common chemo drug thwarts graft rejection in bone marrow transplants cord blood haptoglobin cerebral palsy and death in infants of women at risk for preterm birth a secondary analysis of a randomised controlled trial can a protein in cord blood predict risk of death cerebral palsy in preterm infants ? regulating the femtosecond excited state lifetime of a single molecule single molecule control for a millionth of a billionth of a second shear activated nanotherapeutics for drug targeting to obstructed blood vessels novel nanotherapeutic delivers clot busting drugs directly to obstructed blood vessels exploitation and recovery of a sea urchin predator has implications for the resilience of southern california kelp forests predator versus prey california sheephead s role along pacific coast reduced functional connectivity in adults with persistent post concussion symptoms a functional near infrared spectroscopy study portable brain imaging system to shed light on concussions source duration scales with magnitude differently for earthquakes on the san andreas fault and on secondary faults in parkfield california shallow earthquakes deeper tremors along southern san andreas fault compared by researchers perioperative statin therapy for patients undergoing coronary artery bypass grafting taking statins before heart surgery can help reduce post surgical complications seismic and hydroacoustic observations from underwater explosions off the east coast of florida looking and listening for signals of navy test explosions off florida coast absence of sperm rna elements correlates with idiopathic male infertility improved sperm diagnostic test may pinpoint best fertility treatment for couples three pathogens in sympatric populations of pumas bobcats and domestic cats implications for infectious disease transmission domestic cats and wild bobcats and pumas living in same area have same diseases oral ruxolitinib induces hair regrowth in patients with moderate to severe alopecia areata drug restores hair growth in patients with alopecia areata a connectome wide functional signature of transdiagnostic risk for mental illness brain abnormality indicates general risk for mental illness climate change induced increases in precipitation are reducing the potential for solar ultraviolet radiation to inactivate pathogens in surface waters climate change could decrease sun s ability to disinfect lakes coastal waters pilot study demonstrating metabolic and anti proliferative effects of in vivo anti oxidant supplementation with n acetylcysteine in breast cancer decongestant revealed as highly effective in starving cancer cells cinnamomum cassia bark in two herbal formulas increases life span in caenorhabditis elegans via insulin signaling and stress response pathways tiny worms employed to unlock keys to herbal medicines chikungunya viral arthritis in the united states a mimic of seronegative rheumatoid arthritis shared symptoms of chikungunya virus rheumatoid arthritis may cloud diagnosis designing dual functionalized gels for self reconfiguration and autonomous motion soft robot shaping itself and moving with own internally generated power ? silibinin inhibits ultraviolet b radiation induced dna damage and apoptosis by enhancing interleukin expression in jb cells and skh hairless mouse skin silibinin found in milk thistle protects against uv induced skin cancer age related accumulation of somatic mitochondrial dna mutations in adult derived human ipscs hidden genetic mutations in stem cells could undermine therapeutic benefit correlates of higher dose opioid medication use for low back pain in primary care high dose opioid treatment associated with mental health and medical comorbidities sildenafil suppresses inflammation driven colorectal cancer in mice a small daily dose of viagra may reduce colorectal cancer risk distinct plasma immune signatures in me cfs are present early in the course of illness biological evidence of atypical chronic fatigue syndrome discovered by scientists peak oxygen uptake cut points to identify children at increased cardiometabolic risk the panic study risk factors of type diabetes and cvd accumulate in children with poor aerobic fitness cell size based decision making of a viral gene circuit cell size and cell cycle states play key decision making role in hiv novel toll like receptor antagonist naloxone protects mice from inflammation induced preterm birth drug shows promise for preventing pre term birth the rising prevalence of chronic low back pain chronic low back pain on the rise study finds alarming increase in prevalence interactome analysis reveals znf a a schizophrenia risk gene as a novel component of protein translational machinery critical for embryonic neurodevelopment gene associated with schizophrenia risk regulates early brain development beliefs practices and self efficacy of us physicians regarding smoking cessation and electronic cigarettes a national survey majority of us doctors discussing electronic cigarettes with their patients changing global patterns of urban exposure to flood and drought hazards flood and drought risk to cities on rise even with no climate change serum amyloid a forms stable oligomers that disrupt vesicles at lysosomal ph and contribute to the pathogenesis of reactive amyloidosis harmful protein on acid triggers a life threatening disease study finds the papaver rhoeas s determinants confer self incompatibility to arabidopsis thaliana in planta scientists transfer genes from poppy to a different species to prevent self pollination the future of migraine beyond just another pill evolution of migraine from episodic headache to chronic disorder presence and profile of innate lymphoid cells in human breast milk swat team of immune cells found in mother s milk striatal neurons directly converted from huntington s disease patient fibroblasts recapitulate age associated disease phenotypes altering huntington s patients skin cells into brain cells sheds light on disease formative evaluation of an aba outreach training program for parents of children with autism in remote areas telemedicine training for rural parents of children with autism a new genus of parastenocarididae copepoda harpacticoida from the tocantins river basin goi s brazil and a phylogenetic analysis of the parastenocaridinae new species of brazilian copepod suggests ancient species diversification and distribution dysregulation of neuronal iron homeostasis as an alternative unifying effect of mutations causing familial alzheimer s disease scientists propose a new lead for alzheimer s research the effects of common footwear on joint loading in osteoarthritis of the knee shoes a treatment for osteoarthritis in the knees ? annotation and overview of thepseudomonas savastanoipv. savastanoi ncppb draft genome reveals the virulence gene complement of a tumour inducing pathogen of woody hosts genome of bacteria responsible for tuberculosis of olive tree sequenced older blood is associated with increased mortality and adverse events in massively transfused trauma patients secondary analysis of the proppr trial transfusions with older blood linked to adverse events death new study finds fumarates target the metabolic epigenetic interplay of brain homing t cells in multiple sclerosis how metabolites target brain homing immune cells to treat multiple sclerosis variation at phenological candidate genes correlates with timing of dispersal and plumage morph in a sedentary bird of prey the molecular clock of the common buzzard influence of genes on dispersal behavior revealed anti vegf treatment improves neurological function and augments radiation response in nf schwannoma model adding antiangiogenesis increases effectiveness of radiation against nf associated tumors architecture of the cerebral cortical association connectome underlying cognition internet style local area networks in cerebral cortex of rats vlti amber velocity resolved aperture synthesis imaging of carinae with a spectral resolution of eta carinae vlt interferometer captures raging winds in famous massive stellar system reduced transfusion requirement with use of fresh whole blood in pediatric cardiac surgical procedures using fresh whole blood lowers childrens donor exposure risk in heart surgery antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer sequential doxorubicin and zoledronic acid have powerful anti tumor effect in vivo correlates of heterosexual anal intercourse among at risk adolescents and young adults more at risk teens and young adults engaging in anal intercourse performance of one view breast tomosynthesis as a stand alone breast cancer screening modality results from the malm breast tomosynthesis screening trial a population based study new method detects more breast cancer in screening activation of an il inflammatory loop mediates trastuzumab resistance in her breast cancer by expanding the cancer stem cell population inflammatory pathway spurs cancer stem cells to resist her targeted breast cancer treatment pubertal high fat diet effects on mammary cancer development high fat diet during puberty speeds up breast cancer development pitching a business idea to investors how new venture founders use micro level rhetoric to achieve narrative plausibility and resonance pitch perfect strategic language use maximizes the chances of influencing an audience self reporting colorimetric analysis of drug release by molecular imprinted structural color contact lens color changing contact lens could enhance monitoring of eye disease treatments committed sea level rise under the paris agreement and the legacy of delayed mitigation action sea level legacy cm more rise by for each year delay in peaking emissions identifying early modern human ecological niche expansions and associated cultural dynamics in the south african middle stone age cultural flexibility was key for early humans to survive extreme dry periods in southern africa cyclin a induces cardiac regeneration after myocardial infarction through cytokinesis of adult cardiomyocytes gene therapy a promising tool for cardiac regeneration continued emissions of the ozone depleting substance carbon tetrachloride from eastern asia location of large mystery source of banned ozone depleting substance uncovered new technology reveals the role of giant larvaceans in oceanic carbon cycling lasers shed light on the inner workings of the giant larvacean potential and limits for rapid genetic adaptation to warming in a great barrier reef coral great barrier reef coral predicted to last at least years before extinction from climate change structural basis of mcm replicative helicase loading by orc cdc and cdt orc as loader of the rings study details ringed structure of orc in dna replication elevated mitochondrial bioenergetics and axonal arborization size are key contributors to the vulnerability of dopamine neurons parkinson s disease brain cells at risk of burnout like an overheating motor a randomized trial of intrapartum fetal ecg st segment analysis fetal ecg during labor offers no advantage over conventional fetal heart rate monitoring human lineage specific transcriptional regulation through ga binding protein transcription factor alpha gabpa master switch that plays a key role in energy metabolism human brain evolution deep pelagic food web structure as revealed by in situ feeding observations unique field survey yields first big picture view of deep sea food webs sex differences in glutamate receptor gene expression in major depression and suicide depressed females have over active glutamate receptor gene the serotonin transporter gene moderates the development of emotional problems among children following bullying victimization genetic link to children s emotional problems precipitated by bullying psychiatric effects of protracted conflict and political life events exposure among adolescents in israel teens pay high psychiatric toll when raised in conditions of political conflict variant proteins stimulate more igm gc b cells revealing a mechanism of cross reactive recognition by antibody memory discovery of immune cells able to defend against mutating viruses could transform vaccine development dragon s paradise lost palaeobiogeography evolution and extinction of the largest ever terrestrial lizards varanidae rediscovering the dragon s paradise lost komodo dragons most likely evolved in australia dispersed to indonesia single human b cell derived monoclonal anti candida antibodies enhance phagocytosis and protect against disseminated candidiasis human antibody discovery could save lives from fungal killer olfactory stem cells reveal mocos as a new player in autism spectrum disorders missing piece surfaces in the puzzle of autism fennoscandian freshwater control on greenland hydroclimate shifts at the onset of the younger dryas melting scandinavian ice provides missing link in europe s final ice age story potential biomarkers to follow the progression and treatment response of huntington s disease study identifies new biomarkers for huntington s disease rare earth metals are essential for methanotrophic life in volcanic mudpots rare earth metal essential element for methane munching acid volcano microbe simu dependent clearance of dying cells regulates macrophage function and inflammation resolution dead cells disrupt how immune cells respond to wounds and patrol for infection the association between substance use disorders and mortality among a cohort of veterans with posttraumatic stress disorder variation by age cohort and mortality type substance use disorders linked to increased risk of death for veterans with ptsd innovative assembly strategy contributes to understanding the evolution and conservation genetics of the endangered solenodon paradoxus from the island of hispaniola menomous solenodon last survivor of a branch of mammals that appeared at the time of the dinosaurs sequenced a rapid non invasive procedure for quantitative assessment of drought survival using chlorophyll fluorescence drought tolerant plants ? new technique enables assessment of drought performance symbiont switching and alternative resource acquisition strategies drive mutualism breakdown plant relationships breakdown when they meet new fungi long term risk of neuropsychiatric disease after exposure to infection in utero child s elevated mental ill health risk if mother treated for infection during pregnancy neurodevelopmental low dose bisphenol a exposure leads to early life stage hyperactivity and learning deficits in adult zebrafish early life exposure to bpa affects adult learning animal study suggests post exercise cold water immersion attenuates acute anabolic signalling and long term adaptations in muscle to strength training research pours cold water on ice bath recovery theory arctic warming will promote atlantic pacific fish interchange climate change redistributes fish species at high latitudes systematic network lesioning reveals the core white matter scaffold of the human brain how our brain networks white matter scaffold of human brain revealed particulate air pollution from wildfires in the western us under climate change mapping the health threat of wildfires under climate change in us west huntingtin aggregation impairs autophagy leading to argonaute accumulation and global microrna dysregulation powerful molecules provide new findings about huntington s disease non invasive method of detection of cholesterol using image processing cholesterol test with only a photo of patient s hand wind driven trends in antarctic sea ice drift why antarctic sea ice cover has increased under the effects of climate change human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos new mouse human modeling system enables study of disease development in vivo aging induced stem cell mutations as drivers for disease and cancer when the evil assumes power on the dominance of stem cell mutations in age amblyomma americanum acari ixodidae ticks are not vectors of the lyme disease agent borrelia burgdorferi spirocheatales spirochaetaceae a review of the evidence lone star ticks not guilty in spread of lyme disease quantification of crypt and stem cell evolution in the normal and neoplastic human colon stem cell behavior of human bowel discovered for first time evaluation of a thoracic focused assessment with sonography for trauma tfast protocol to detect pneumothorax and concurrent thoracic injury in traumatized dogs trauma in dogs and cats novel veterinary procedure detecting life threatening injuries touted estimating the respective contributions of human and viral genetic variation to hiv control genetics of both virus and patient work together to influence the course of hiv infection prehistoric dentistry ? p rotation partial m impaction toothpick grooves and other signs of manipulation in krapina dental person analysis of neanderthal teeth grooves uncovers evidence of prehistoric dentistry evolutionary genetics of immunological supertypes reveals two faces of the red queen fish provide insight into the evolution of the immune system plain cigarette packs do not exert pavlovian to instrumental transfer of control over tobacco seeking plain packaging reduces cigarette seeking response by almost ten percent the hsp interdomain linker is a dynamic switch that enables allosteric communication between two structured domains biochemists simulate a protein folding chaperone s functional dance evidence of former majoritic garnet in himalayan eclogite points to km deep subduction of indian continental crust deep subduction of the indian continental crust beneath asia c pathway analysis for the role of formate in electricity generation by shewanella oneidensis mr using lactate in microbial fuel cells scientists unlock key to turning wastewater and sewage into power detection of peginesatide in equine serum using liquid chromatography tandem mass spectrometry for doping control purposes horse racing doping detection stays a neck ahead efficacy and safety of surgical decompression in patients with cervical spondylotic myelopathy results of the aospine north america prospective multi center study new treatment for arthritis of the spine prevents paralysis randomised trial of text messaging on adherence to cardiovascular preventive treatment interact trial text messages prevent one in six patients from failing to take medicine migration in the anthropocene how collective navigation environmental system and taxonomy shape the vulnerability of migratory species vulnerability and extinction risk of migratory species from different regions and ecosystems worldwide resonant secondary light emission from plasmonic au nanostructures at high electron temperatures created by pulsed laser excitation understanding secondary light emission by plasmonic nanostructures may improve medical imaging crf cpx is an evolutionary fit hiv variant strongly associated with rapid progression to aids in cuba aggressive form of hiv uncovered in cuba hiv to aids in three years global noncommunicable diseases lessons from the hiv aids experience global fight against non communicable diseases should take lessons from hiv aids say experts silicon cmos architecture for a spin based quantum computer complete design of a silicon quantum computer chip unveiled mathematical modeling of herpes simplex virus suppression with pritelivir predicts trial outcomes model helps decide drug dose for clinical testing effect of electronic cigarette use on cough reflex sensitivity e cigarette use linked to cough reflex sensitivity frailty and adherence to adjuvant hormonal therapy in older women with breast cancer calgb protocol majority of older breast cancer patients use hormone treatment immunologic correlates of the abscopal effect in a patient with melanoma rare medical phenomenon of systemic tumor disappearance following local radiation treatment reported in a patient with metastatic melanoma pharmaceutical grade chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic knee osteoarthritis the chondroitin versus celecoxib versus placebo trial concept chondroitin sulfate as good as widely used anti inflammatory for knee osteoarthritis evaluation of a minimally disruptive treatment protocol for frontal sinus fractures evaluating a minimally disruptive treatment protocol for frontal sinus fractures naturalization of european plants on other continents the role of donor habitats head start through human intervention study on the spread of european plant species on other continents long term effects of intensive glycemic and blood pressure control and fenofibrate use on kidney outcomes study questions certain treatments for diabetic patients at high risk for heart disease genetic suppression reveals dna repair independent antagonism between brca and cobra in mammary gland development new insights reported about the angelina jolie gene roadway proximity and risk of sudden cardiac death in women living near major roads may increase risk of sudden cardiac death in women dental fillings for the treatment of caries in the primary dentition no clear winner among fillings for childhood cavities electro acupuncture to prevent prolonged postoperative ileus a randomized clinical trial does electro acupuncture prevent prolonged postoperative ileus ? germline cas expression yields highly efficient genome engineering in a major worldwide disease vector aedes aegypti scientists create yellow three eyed wingless mosquitoes by using gene editing tool a first choice combined oral contraceptive influences general well being in healthy women a double blind randomized placebo controlled trial oral contraceptives reduce general well being in healthy women swedish study finds the impact of menopause on functional status in women with rheumatoid arthritis menopause found to worsen symptoms of rheumatoid arthritis less dementia with oral anticoagulation in atrial fibrillation blood thinning drugs appear to protect against dementia as well as stroke in patients with atrial fibrillation putative linkage signals identified for breast cancer in african american families previously unknown genomic regions found in african american families with breast cancer time to eligibility for antiretroviral therapy in adults with cd cell count cells l in rural kwazulu natal south africa gender difference in vital cell count of hiv patients do functional impairments promote or hinder mental health treatment seeking differential results for women and men relationship impairments hinder men seeking mental health treatment gut microbiota derived tryptophan metabolites modulate inflammatory response in hepatocytes and macrophages gut check metabolites shed by intestinal microbiota keep inflammation at bay effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction exercise diet improves ability to exercise for patients with common type of heart failure increased maternal and fetal cholesterol efflux capacity and placental cyp a expression in preeclampsia new clues in puzzle over pre eclampsia and cholesterol regulation your job is messing with mine ! the impact of mobile device use for work during family time on the spouse s work life. use of mobile devices at home can carry conflict to workplace study says two hours of evening reading on a self luminous tablet vs. reading a physical book does not alter sleep after daytime bright light exposure plenty of light during daytime reduces the effect of blue light screens on night sleep managing revenue across retail channels the interplay of service performance and direct marketing catering to needs of in store online customers boosts marketing effectiveness revenue infant temperament and parent use of food to soothe predict change in weight for length across infancy early risk factors for childhood obesity parenting and personality work together to affect baby s weight gain a bio inspired swellable microneedle adhesive for mechanical interlocking with tissue better skin grafting inspired by spiny headed worms scientists invent microneedle adhesive stronger than surgical staples improving reading outcomes in kenya first year effects of the primr initiative primary school reading initiative boosts literacy in kenya neutron skin thickness of ca from a nonlocal dispersive optical model analysis predictive framework thick skin of atomic nucleus discovered by chemistry physics research group lsd engages a corepressor complex for the activation of the estrogen receptor by estrogen and camp understanding the resistance to treatments against breast cancer microrna and microrna b are tissue and circulating biomarkers of recurrent papillary thyroid cancer measuring segments of genetic material may help predict monitor recurrence of thyroid cancer urban vs rural residence and the prevalence of depression and mood disorder among african american women and non hispanic white women rural african american women had lower rates of depression mood disorder moderate to vigorous physical activity and all cause mortality do bouts matter ? whether sustained or sporadic exercise offers same reductions in premature death risk observations of solar coronal rain in null point topologies unexpected coronal rain on sun links two solar mysteries association of antipsychotic use with mortality risk in patients with parkinson disease antipsychotic drugs linked to increased mortality among parkinson s disease patients brain activation patterns in women with acquired hypoactive sexual desire disorder and women with normal sexual function a cross sectional pilot study distinctive brain blood flow patterns associated with sexual dysfunction human ipsc derived retinal pigment epithelium a model system for prioritizing and functionally characterizing causal variants at amd risk loci personalized eye in a dish models reveal genetic underpinnings of macular degeneration load discharge relationships reveal the efficacy of manure application practices on phosphorus and total solids losses from agricultural fields manure injection offers hope challenge for restoring chesapeake water quality a dna pkcs mutation in a radiosensitive t b scid patient inhibits artemis activation and nonhomologous end joining new genetic cause of boy in the bubble syndrome lineage specific enhancers activate self renewal genes in macrophages and embryonic stem cells role model stem cells how immune cells can self renew purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice new experimental vaccine produces immune response against mers virus ultra large library docking for discovering new chemotypes virtual pharmacology advance tackles universe of unknown drugs sex specific association between coronary artery disease severity and myocardial ischemia induced by mental stress stress induced effects on heart blood flow differ for men versus women psychiatric symptoms in norwegian children with epilepsy aged years effects of age and gender ? higher prevalence of psychiatric symptoms found in children with epilepsy poststroke delivery of manf promotes functional recovery in rats post stroke delivery of neurotrophic factor manf promotes functional recovery in rats abnormal neurogenesis and cortical growth in congenital heart disease hypoxia due to chd linked to abnormal neurogenesis and impaired cortical growth patches of disorganization in the neocortex of children with autism autism begins in pregnancy according to study cortical layers disrupted during brain development in autism the impact of legally restricted embryo transfer and reimbursement policy on cumulative delivery rate after treatment with assisted reproduction technology delivery rates unaffected by transferring fewer embryos reimbursing six cycles of fertility treatment influence of childhood behaviour on the reporting of chronic widespread pain in adulthood results from the british birth cohort study behavioral problems in childhood doubles the risk of chronic widespread pain in adult life investigation of sex differences in the expression of rora and its transcriptional targets in the brain as a potential contributor to the sex bias in autism differences in rora levels in brain may contribute to autism sex bias airborne laser guided imaging spectroscopy to map forest trait diversity and guide conservation high tech maps of tropical forest diversity identify new conservation targets pregnancy after age defining risks for mother and child risks of pregnancy via egg donation similar for women over age as for younger women surface state mediated charge transfer of cs sni and its application in dye sensitized solar cells new class of solar cells using lead free perovskite materials apixaban in patients at risk of stroke undergoing atrial fibrillation ablation trial shows safety of drugs for irregular heartbeat patients undergoing treatment early neanderthal constructions deep in bruniquel cave in southwestern france neanderthals used fire in caves french cave sheds new light on the neanderthals transgenic sexing system for genetic control of the australian sheep blow fly lucilia cuprina genetic control mechanism for major livestock pest developed feasibility of a clinical chemical analysis approach to predict misuse of growth promoting hormones in cattle new test to identify illegal steroids in cattle proteomics of human lung tissue identifies surfactant protein a as a marker of chronic obstructive pulmonary disease advance toward early diagnosis of chronic obstructive pulmonary disease distance to retail stores and risk of being homebound among older adults in a city severely affected by the great east japan earthquake many older adults still homebound after great east japan earthquake lobefinder a convex hull based method for quantitative boundary analyses of lobed plant cells lobefinder technology quantifies changes in shape shifting plant cells a single mutation in the envelope protein modulates flavivirus antigenicity stability and pathogenesis single mutation may impact infectivity of west nile and similar viruses a secreted bacterial protease tailors the staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis a new model and possible treatment for staph bone infections persistent racial disparity in stroke hospitalization and economic impact in young adults in the buckle of stroke belt stroke hospitalizations up among middle aged blacks in south carolina validation of chromosomal locations of k array single nucleotide polymorphisms in us wheat new wheat genetic advancements aimed at yield enhancement cell wall traits as potential resources to improve resistance of durum wheat against fusarium graminearum new hope for fighting major fungal disease in durum wheat mirtazapine added to ssris or snris for treatment resistant depression in primary care phase iii randomised placebo controlled trial mir drug combination for treatment resistant depression no more effective than single nuclear localized cyclic nucleotide gated channels mediate symbiotic calcium oscillations missing link in plant nitrogen fixation process discovered repetition and severity of suicide attempts across the life cycle a comparison by age group between suicide victims and controls with severe depression elderly suicide risk after previous attempts varies by sex enteric bacteria promote human and mouse norovirus infection of b cells researchers discover how to cultivate norovirus in human cells comparing the cost effectiveness of nature based and coastal adaptation a case study from the gulf coast of the united states nature based solutions can prevent billion in gulf coast flood damages anomalous concentration of methane emissions at the continental shelf edge of the northern cascadia margin hundreds of bubble streams link biology seismology off washington s coast crucial role for outdoor chemistry in ultrafine particle formation in modern office buildings green walls red card for office worker health ? volatile chemical products emerging as largest petrochemical source of urban organic emissions consumer and industrial products now a dominant urban air pollution source broadband electrically tunable third harmonic generation in graphene graphene paves the way to faster high speed optical communications niche filling slows the diversification of himalayan songbirds competition for ecological niches limits the formation of new species single tablet hiv regimens facilitate virologic suppression and retention in care among treatment na ve patients single tablet hiv treatment shows better outcomes over multi tablet regimen intravenous delivery of a multi mechanistic cancer targeted oncolytic poxvirus in humans world first viral therapy trial in cancer patients effects of before school physical activity on obesity prevention and wellness before school physical activity program helps improve body weight and overall wellness immunomodulation accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina immune system found to control eye tissue renewal in zebrafish intake of fruits and vegetables in relation to year weight gain among spanish adults mediterranean diet reduces long term risk of subsequent weight gain and obesity among adults attention deficit hyperactivity disorder symptoms in offspring of mothers with impaired serotonin production adhd more common in offspring of mothers with genetic serotonin deficiencies multivariate biophysical markers predictive of mesenchymal stromal cell multipotency world s first novel method for label free identification of stem cells will lead to more consistent efficacious stem cell therapies experts say engineering patient specific valves using stem cells generated from skin biopsy specimens skin cells can be engineered into pulmonary valves for pediatric patients an increase of bone mineral density in male to female and female to male transgender persons after one year cross sex hormonal treatment hormone treatment in transgender persons could shed light on role of sex hormones in bone density the role of environmental factors in search and rescue incidents in nunavut canada researchers work to understand causes of search and rescue in the arctic episodic organic carbon fluxes from surface ocean to abyssal depths during long term monitoring in ne pacific pulses of sinking carbon reaching the deep sea are not captured in global climate models effect of a low free sugar diet vs usual diet on nonalcoholic fatty liver disease in adolescent boys a randomized clinical trial diet low in added sugars significantly improves fatty liver disease in children reevaluation of diagnosis in adults with physician diagnosed asthma diabetes in chinese adults linked to years loss of life association of dietary cholesterol and egg intakes with the risk of incident dementia or alzheimer disease the kuopio ischaemic heart disease risk factor study high cholesterol intake and eggs do not increase risk of memory disorders denervation activated stat il signalling in fibro adipogenic progenitors promotes myofibres atrophy and fibrosis dr. jekyll mr. hyde healing mesenchymal cells morph and destroy muscles in models of spinal cord injury als and spinal muscular atrophy a collaborative multiyear multimodel assessment of seasonal influenza forecasting in the united states assessing the performance of multiple influenza forecasting models thymic stromal lymphopoietin elicited basophil responses promote eosinophilic esophagitis rare immune cells promote food induced allergic inflammation in the esophagus the homozygote vcpr h r h mouse model exhibits accelerated human vcp associated disease pathology new research model to aid search for degenerative disease cures running exercise mitigates the negative consequences of chronic stress on dorsal hippocampal long term potentiation in male mice running helps brain stave off effects of chronic stress positive site selection bias in meta analyses comparing natural regeneration to active forest restoration natural regeneration or tree planting ? study points to bias in forest restoration studies online posting of unprofessional content by medical students many medical schools report incidents of students posting unprofessional content online gaps in primary care and health system performance in six latin american and caribbean countries latin american caribbean health systems need more investment as populations age predictors of responsible drinking or abstinence among college students who binge drink a multitheory model approach model for cutting binge drinking in college students derivation of myogenic progenitors directly from human pluripotent stem cells using a sphere based culture new way to make muscle cells from human stem cells not just a mothers problem the consequences of perceived workplace flexibility bias for all workersg workplace flexibility bias not just a mother s problem arrival by ambulance explains variation in mortality by time of admission retrospective study of admissions to hospital following emergency department attendance in england new study shows major omission in evidence of weekend effect on mortality rates in hospitals a prescription at discharge improves long term adherence for secondary stroke prevention prescription for better stroke care prescription at discharge improves outcomes syngap haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly closer than ever to a personalized treatment solution for intellectual disability video analysis of the biomechanics of a bicycle accident resulting in significant facial fractures video of failed bike stunt lends insights into biomechanics of facial fracture subduction flux modulates the geomagnetic polarity reversal rate new insight into earth s crust mantle and outer core interactions live imaging reveals the progenitors and cell dynamics of limb regeneration first time lapse footage of cell activity during limb regeneration induction of long term protective immune responses by influenza h n virus like particles novel pandemic flu vaccine effective against h n in mice receipt of preventive medical care and medical screening for patients with mental illness a comparative analysis people with mental illness receive inadequate mass screening for prevention of medical conditions uk study finds a gene encoding maize caffeoyl coa o methyltransferase confers quantitative resistance to multiple pathogens corn gene conferring resistance to multiple plant leaf diseases pnas plus c terminus of hsc interacting protein chip mediated degradation of hippocampal estrogen receptor and the critical period hypothesis of estrogen neuroprotection long periods of estrogen deprivation jeopardizes brain receptors stroke protection karyotype characteristics and chromosomal polymorphism of chironomus annularius sensu strenzke diptera chironomidae from the caucasus region mosquito populations give a new insight into the role of caucasus in evolution cardiorespiratory fitness in middle age and health care costs in later life midlife fitness helps reduce health costs after age genome editing reveals a role for oct in human embryogenesis genome editing reveals role of gene important for human embryo development circadian waves of transcriptional repression shape pif regulated photoperiod responsive growth in arabidopsis the circadian clock sets the pace of plant growth duration of antibiotic treatment for common infections in english primary care cross sectional analysis and comparison with guidelines many antibiotic courses for common infections not in line with guidelines recurrent infection progressively disables host protection against intestinal inflammation gut reaction repeated mild food poisoning triggers chronic disease contribution of sensory processing to chronic constipation in preschool children preschoolers with chronic constipation tend to be picky eaters effect of home monitoring via mobile app on the number of in person visits following ambulatory surgery a randomized clinical trial use of mobile app reduces number of in person follow up visits after surgery normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men normalization of testosterone level after testosterone replacement therapy could decrease risk of cardiovascular events and mortality in men association of digital media use with subsequent symptoms of attention deficit hyperactivity disorder among adolescents digital media use linked to behavioral problems in kids injuries associated with strollers and carriers among children in the united states average of two injuries every hour in the us from strollers carriers childhood and adolescent adversity and cardiometabolic outcomes a scientific statement from the american heart association abuse and adversity in childhood linked to more cardiovascular risk in adulthood epidemiology of overuse injuries among high school athletes in the united states girls at higher risk for overuse injuries in high school sports a tetravalent dengue virus vaccine based on a complex adenovirus vector provides significant protection in rhesus monkeys against all four serotypes of dengue virus new vaccine may protect against all four strains of dengue virus prevalence of and factors associated with head impact during falls in older adults in long term care seniors in long term care residences high risk of head injuries hormonal predictors of sexual motivation in natural menstrual cycles hormone levels and sexual motivation among young women organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease mini kidneys grown in lab reveal renal disease secrets dietary diabetes risk reduction score race and ethnicity and risk of type diabetes in women healthy diet associated with lower risk of type diabetes in minority women oxidation increases mucin polymer cross links to stiffen airway mucus gels cystic fibrosis discovery may lead to new treatment strategy help patients breathe easier risky trade individual and neighborhood level socio demographics associated with transactional sex among urban african american msm hiv risk and individual and community level educational status rethinking agricultural trade relationships in an era of globalization unraveling the complex web of global food trade workforce for st century health and health care healthcare leaders recommend restructuring health care system to better serve needs of u.s. throughout st century somatic inactivating ptprj mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis canine melanoma study identifies genetic basis of disease potential drug targets sentinel lymph node biopsy is accurate and prognostic in head and neck melanoma sentinel node biopsy safe effective in head and neck melanomas study finds novel fire extinguisher method using vacuuming force applicable to space habitats new concept for novel fire extinguisher in space red blood cell transfusion and mortality in trauma patients risk stratified analysis of an observational study transfusion after trauma can benefit or harm patients depending on their risk of death diagnosis and management of prosthetic joint infection clinical practice guidelines by the infectious diseases society of america new idsa guidelines aim to reduce death disability and cost of prosthetic joint infections effect of structured physical activity on prevention of serious fall injuries in adults aged randomized clinical trial life study physical activity reduces risk of serious falls in older men distress intolerance and prescription opioid misuse among patients with chronic pain study shows distress intolerance associated with opioid misuse spindle cell carcinoma of the tongue a rare variant of squamous cell carcinoma rare form of tongue cancer suggests screening vigilance single virus droplet microfluidics for high throughput screening of neutralizing epitopes on hiv particles sorting out hiv research collaboration devises a new method that could speed up vaccine development for hiv porphyrin adsorbed allograft bone a photoactive antibiofilm surface photoactive dye could prevent infection during bone repair surgery post operative mortality missed care and nurse staffing in nine countries a cross sectional study missed nursing care due to low nurse staffing increases patient mortality the dynamics of gene expression in vertebrate embryogenesis at single cell resolution genetic roadmap to building an entire organism from a single cell temperature sensitive cav. calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures new therapy target for kids fever induced seizures asfotase improves bone growth mineralization and strength in mouse models of neurofibromatosis type novel treatment strengthens bones in genetic disease neurofibromatosis type arterial smooth muscle cell pkd trpp channels regulate systemic blood pressure new drug target discovered for potential blood pressure treatment polymorphonuclear leukocytes restrict growth of pseudomonas aeruginosa in the lungs of cystic fibrosis patients cystic fibrosis lung infection scientists open black box on bacterial growth targeting tumor mitochondrial metabolism overcomes resistance to antiangiogenics researchers discover a mechanism that reverses resistance to antiangiogenic drugs structures of respiratory syncytial virus g antigen bound to broadly neutralizing antibodies antigen study supports new approach to vaccine for respiratory syncytial virus long term outcomes after stenting versus endarterectomy for treatment of symptomatic carotid stenosis the international carotid stenting study icss randomised trial stenting safe effective for long term stroke prevention bystander chronic infection negatively impacts development of cd t cell memory bystander chronic infections thwart development of immune cell memory an ancient selective sweep linked to reproductive life history evolution in sockeye salmon ancient genetic markers in sockeye salmon can help manage healthier fish stocks efficacy and safety of ldl lowering therapy among men and women meta analysis of individual data from participants in randomised trials breakthrough statin treatment reduces risk of cardiovascular disease in women immunogenic stimulus for germline precursors of antibodies that engage the influenza hemagglutinin receptor binding site first flu exposure imprints itself on immune system complex dna damage induced by high linear energy transfer alpha particles and protons triggers a specific cellular dna damage response how cancer cells repair themselves following proton beam therapy biomechanical simulations of leptarctus primus leptarctinae carnivora and new evidence for a badger like feeding capability extinct weasel relative with confounding skull likely ate meat with a side of veggies epigenetic inheritance and the missing heritability problem genetics nature or nurture ? new epigenetic model blurs line in the debate statin use and risk of gallstone disease followed by cholecystectomy long term statin use associated with decreased risk of gallstones requiring surgery the distribution of road salt in private drinking water wells in a southeastern new york suburban township road salt pollutes drinking water wells in suburban new york state quality of care provided by mid level health workers systematic review and meta analysis in shortages mid level health workers as effective as physicians for certain services link of a ubiquitous human coronavirus to dromedary camels common cold viruses originated in camels just like mers role of type i interferon ifn in the respiratory syncytial virus rsv immune response and disease severity pediatric health researchers offer insights for rsv vaccine seroepidemiological evidence of avian influenza a virus transmission to pigs in southern china pigs in southern china infected with avian flu disgusting clusters trypophobia as an overgeneralised disease avoidance response coffee bubble phobia may be deep seated aversion to parasites an excess of massive stars in the local doradus starburst weighing massive stars in nearby galaxy reveals excess of heavyweights distinct immunoallertypes of disease and high frequencies of sensitization in non cystic fibrosis bronchiectasis lung disease bronchiectasis associated with high frequency of allergy deficient activity in the neural systems that mediate self regulatory control in bulimia nervosa brain circuit abnormalities may underlie bulimia nervosa in women dicaffeoylquinic acids in yerba mate ilex paraguariensis st. hilaire inhibit nf b nucleus translocation in macrophages and induce apoptosis by activating caspases and in human colon cancer cells compounds in mate tea induce death in colon cancer cells in vitro study shows seven steps to success a handout for parents of overweight children and adolescents seven steps to successful child and adolescent weight loss changes in the frequency of airway infections in smokers who switched to vaping results of an online survey vaping may lead to fewer respiratory infections for ex smokers randomized polypill crossover trial in people aged and over first polypill trial in people selected on age alone and over shows substantial health benefit efficacy of whole cell killed bacterial vaccines in preventing pneumonia and death during the influenza pandemic secondary infections were a major cause of death during flu pandemic research finds the efficacy and safety of abatacept in patients with non life threatening manifestations of sle results of a month exploratory study abatacept found ineffective in treatment of non life threatening lupus trial results show expanding the chemical space of biocompatible fluorophores nanohoops in cells chemists create circular fluorescent dyes for biological imaging electronic health record cue identifies epilepsy patients at risk for obstructive sleep apnea new screening tool can improve the quality of life for epilepsy patients with sleep apnea biologic therapies and bone loss in rheumatoid arthritis biologic therapies for rheumatoid arthritis may protect against rapid bone loss effects of diet composition and insulin resistance status on plasma lipid levels in a weight loss intervention in women cholesterol levels improve with weight loss healthy fat rich diet experiential or material purchases ? social class determines purchase happiness social class determines whether buying experiences or things brings greater happiness zoonotic source attribution of salmonella enterica serotype typhimurium using genomic surveillance data united states scientists use machine learning to id source of salmonella cultural transmission of tool use combined with habitat specializations leads to fine scale genetic structure in bottlenose dolphins cultural hitchhiking how social behavior can affect genetic makeup in dolphins ancient origin of the modern deep sea fauna new fossils suggest ancient origins of modern day deep sea animals a molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells new way to screen for brain cancer stem cell killers brain white matter structure and comt gene are linked to second language learning in adults success in second language learning linked to genetic and brain measures an ectosteric inhibitor of cathepsin k inhibits bone resorption in ovariectomized mice new osteoporosis treatment uses traditional chinese herb to prevent bone loss the onset of star formation million years after the big bang evidence for stars forming just million years after big bang roll spin wash or filter ? processing of lipoaspirate for autologous fat grafting best way to prepare fat cells for grafting ? jury s still out neuron targeted nanoparticle for sirna delivery to traumatic brain injuries curbing the life long effects of traumatic brain injury sleep duration is associated with sperm chromatin integrity among young men in chongqing china sleep duration may affect the integrity of sperm dna midlife physical activity and cognition later in life a prospective twin study midlife physical activity is associated with better cognition in old age funneling aromatic products of chemically depolymerized lignin into pyrone dicarboxylic acid with novosphingobium aromaticivorans engineered microbe may be key to producing plastic from plants evolution of a stream ecosystem in recently deglaciated terrain evolution of a stream plants and sea life claim new territory as glaciers retreat in glacier bay alaska pole to pole connections similarities between arctic and antarctic microbiomes and their vulnerability to environmental change tiny globetrotters bacteria which live in the arctic and the antarctic rapid repeat pregnancy among women with intellectual and developmental disabilities a population based cohort study women with intellectual and developmental disabilities have almost double the rate of repeat pregnancy arm pain in youth baseball players a survey of healthy players arm pain in young baseball players common preventable cadm is essential for kshv encoded vgpcr and vflip mediated chronic nf b activation molecular culprit behind virus mediated chronic inflammation and cancers identified molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells two step mechanism of inner ear tip link regrowth biologic therapy adherence discontinuation switching and restarting among patients with psoriasis in the us medicare population medicare patients have low adherence to biologic drug therapy for psoriasis elucidation of the ebola virus vp cellular interactome and disruption of virus biology through targeted inhibition of host cell protein function. finding new approaches for therapeutics against ebola virus reactivation of multiple viruses in patients with sepsis dormant viruses re emerge in patients with lingering sepsis signaling immune suppression recent drought and tree mortality effects on the avian community in southern sierra nevada a glimpse of the future ? recent drought may provide a glimpse of the future for birds in the sierra nevada platelet targeted gene therapy with human factor viii establishes haemostasis in dogs with haemophilia a new gene therapy proves promising as hemophilia treatment molecular transport through capillaries made with atomic scale precision atomic scale pipes available on demand and by design a computational solution to improve biomarker reproducibility during long term projects new software aims to reduce variability in elisa biomarker tests prescription opioid use among adults with mental health disorders in the united states more than half of all opioid prescriptions go to people with mental illness sexuality and cognitive status a u.s. nationally representative study of home dwelling older adults the link between cognitive function and sexuality in older adults pan antarctic analysis aggregating spatial estimates of ad lie penguin abundance reveals robust dynamics despite stochastic noise year to year volatility of penguin population requires new approaches to track marine health a strontium and chlorine free pyrotechnic illuminant of high color purity environmentally safe red glare rocket changes fireworks soldier technology population structure of a widespread bat tadarida brasiliensis in an island system ocean channel in bahamas marks genetic divide in brazilian free tailed bats coffee intake recurrence and mortality in stage iii colon cancer results from calgb alliance drinking coffee daily may improve survival in colon cancer patients dynamic gene regulatory networks drive hematopoietic specification and differentiation big data helps to discover key factors driving blood cell specification influence of the timing of antiretroviral therapy on the potential for normalization of immune status in human immunodeficiency virus infected individuals delaying art in patients with hiv reduces likelihood of restoring cd counts association of age at onset of menopause and time since onset of menopause with cardiovascular outcomes intermediate vascular traits and all cause mortality premature or early onset menopause associated with increased risk of coronary heart disease cardiovascular disease mortality all cause mortality organic carbon content drives methylmercury levels in the water column and in estuarine food webs across latitudes in the northeast united states research forms complex picture of mercury pollution in a period of global change pain management in cancer center inpatients a cluster randomized trial to evaluate a systematic integrated approach the edinburgh pain assessment and management tool cancer patients pain eased by simple bedside chart pros prospero is a major regulator of the glia specific secretome controlling sensory neuron shape and function in c. elegans common brain cell shapes the nervous system in unexpected ways optical metabolic imaging identifies glycolytic levels subtypes and early treatment response in breast cancer new imaging technique can identify breast cancer subtypes early treatment response electric field induced release and measurement liquid biopsy for noninvasive early lung cancer assessment novel technology enables detection of early stage lung cancer when surgical cure still is possible reconstruction of the cortical maps of the tasmanian tiger and comparison to the tasmanian devil the tasmanian tiger had a brain structure suited to a predatory life style restoring natural forearm rotation in transradial osseointegrated amputees artificial joint restores wrist like movements to forearm amputees false identification use among college students increases the risk for alcohol use disorder results of a longitudinal study use of false id by youth to buy alcohol is slippery slope toward alcohol use disorders regional asynchronicity in dairy production and processing in early farming communities of the northern mediterranean widespread evidence of prehistoric dairying discovered along the mediterranean coast reduction in firearm injuries during nra annual conventions firearm injuries drop during nra conventions research shows cationic antimicrobial peptides promote microbial mutagenesis and pathoadaptation in chronic infections low dose natural antimicrobial exacerbates chronic lung infection in cystic fibrosis use of a pathway quality improvement care bundle to reduce mortality after emergency laparotomy new care bundle achieves drop in death rate for emergency abdominal surgery patients prospective study evaluating na f pet ct in predicting clinical outcomes and survival in advanced prostate cancer predicting advanced prostate cancer outcomes with naf pet ct early intervention during acute stone admissions revealing the weekend effect in urological practice kidney stone patients hospitalized on the weekend may get delayed treatment the role of copper and vitamin a deficiencies leading to neurological signs in captive cheetahs acinonyx jubatus and lions panthera leo in the united arab emirates new study links neurological disorders in captive felids to improper diet interpersonal positive reframing in the daily lives of couples coping with breast cancer coping with cancer partners can reframe challenging situations ancient egyptian mummy genomes suggest an increase of sub saharan african ancestry in post roman periods the first genome data from ancient egyptian mummies cesium titanium iv bromide thin films based stable lead free perovskite solar cells new lead free perovskite material for solar cells secular decrease of wind power potential in india associated with warming in the indian ocean wind power vulnerable to climate change in india selling stem cells in the usa assessing the direct to consumer industry surprising number of businesses selling unapproved stem cell treatments in the us early changes in csf strem in dominantly inherited alzheimers disease occur after amyloid deposition and neuronal injury early signs of alzheimer s detected in cerebrospinal fluid first report of naturally infected aedes aegypti with chikungunya virus genotype ecsa in the americas first chikungunya infected aedes aegypti mosquitoes found in brazil associations of artificially sweetened beverage intake with disease recurrence and mortality in stage iii colon cancer results from calgb alliance low or no calorie soft drinks linked to improved outcomes in colon cancer ketone body acetoacetate buffers methylglyoxal via a non enzymatic conversion during diabetic and dietary ketosis the body s own fat metabolism protects against the harmful effects of sugar land degradation indicators and management options in the desert environment of abu dhabi united arab emirates wind salt and water are leading indicators of land degradation in abu dhabi desert lands digital mammography versus digital mammography plus tomosynthesis for breast cancer screening the reggio emilia tomosynthesis randomized trial more breast cancers found with combined digital screening myb qki rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism genetic cause identified in rare pediatric brain tumor development of a primary human small intestine on a chip using biopsy derived organoids true to type from human biopsy to complex gut physiology on a chip histamine receptor h mediated sensitization of trpv mediates visceral hypersensitivity and symptoms in patients with irritable bowel syndrome hay fever medicine reduces symptoms of irritable bowel syndrome dense genotyping of immune related disease regions identifies new susceptibility loci for juvenile idiopathic arthritis discovery of new genes will help childhood arthritis treatment dietary therapy to promote neuroprotection in chronic spinal cord injury. laboratory investigation curry spice omega fatty acid preserve walking ability following spinal cord injury a framework for engineering stress resilient plants using genetic feedback control and regulatory network rewiring rewiring plant defense genes to reduce crop waste effects of high intensity resistance aquatic training on body composition and walking speed in women with mild knee osteoarthritis a month rct with month follow up intensive aquatic resistance training decreases body fat mass and improves physcial function in women with mild knee osteoarthritis new infant cranium from the african miocene sheds light on ape evolution new million year old infant skull sheds light on ape ancestry modeling of the putative distribution of the arbovirus vector ochlerotatus japonicus japonicus diptera culicidae in germany asian rock pool mosquitoes on the move modeling identifies risk hotspots in germany pod intravaginal rings delivering antiretroviral combinations for hiv prophylaxis pharmacokinetics and preliminary safety in a macaque model novel intravaginal ring shows promise for hiv prevention engaging to end the epidemic seven essential steps toward an aids free generation new report describes seven essential steps toward an aids free generation interaction of lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved post myocardial infarction healing mice with missing lipid modifying enzyme heal better after heart attack global regional and national levels and trends in maternal mortality between and with scenario based projections to a systematic analysis by the un maternal mortality estimation inter agency group despite substantial progress the world fell short of the maternal mortality target in the millennium development goals un report shows large cardiac muscle patches engineered from human induced pluripotent stem cell derived cardiac cells improve recovery from myocardial infarction in swine heart muscle patches made with human cells improve heart attack recovery denture wearing during sleep doubles the risk of pneumonia in the very elderly sleeping in dentures doubles risk of pneumonia in elderly continued use of the standard days method r long term effectiveness of new family planning method shown in study transition from battery to pseudocapacitor behavior via structural water in tungsten oxide thin layers of water hold promise for the energy storage of the future storm deposited coral blocks a mechanism of island genesis tutaga island funafuti atoll tuvalu catastrophic construction storms can build reef islands in atoll regions metabolic effects of bariatric surgery in patients with moderate obesity and type diabetes analysis of a randomized control trial comparing surgery with intensive medical treatment bariatric surgery restores pancreatic function by targeting belly fat trking down an old oncogene in a new era of targeted therapy cancer causing mutation discovered in finally target of clinical trials one hundred years of arctic surface temperature variation due to anthropogenic influence a century of human impact on arctic climate indicated by new models historic aerosol data hindcasting global population densities reveals forces enabling the origin of agriculture on the origins of agriculture researchers uncover new clues glial acetate metabolism is increased following a h fast in metabolically healthy men and correlates with susceptibility to hypoglycemia preventing dangerous episodes of low blood sugar with diabetes study provides next clue greater response to placebo in children than in adults a systematic review and meta analysis in drugresistant partial epilepsy greater response to placebo in children than in adults entire photodamaged chloroplasts are transported to the central vacuole by autophagy collapsed chloroplasts are targeted in self eating process the effects of social capital and neighborhood characteristics on intimate partner violence a consideration of social resources and risks research highlights link between neighborhood and partner violence younger children experience lower levels of language competence and academic progress in the first year of school evidence from a population study new study calls for radical shake up of the early years curriculum to help boost achievements of summer born children predicting interest in cosmetic surgery interactive effects of appearance based rejection sensitivity and negative appearance comments cosmetic surgery appeals to men women with appearance based rejection sensitivity quantification of retinogenesis in d cultures reveals epigenetic memory and higher efficiency in ipscs derived from rod photoreceptors new measurements reveal differences between stem cells for treating retinal degeneration functional maturation in preterm infants measured by serial recording of cortical activity artificial intelligence to evaluate brain maturity of preterm infants evaluation of granular anaerobic ammonium oxidation process for the disposal of pre treated swine manure new data for old bones how the famous cleveland lloyd dinosaur bone bed came to be maternal smoking during pregnancy and timing of puberty in sons and daughters a population based cohort study earlier puberty linked to mother s smoking during pregnancy sequence variations of the human mpdz gene and association with alcoholism in subjects with european ancestry gene brings together animal and human research in alcoholism among those with european ancestry peg lipid micelles enable cholesterol efflux in niemann pick type c disease based lysosomal storage disorder system may help treat rare genetic disorder reduce severe side effects managing trap nesting bees as crop pollinators spatiotemporal effects of floral resources and antagonists nesting aids make agricultural fields attractive for bees changes in child exposure to secondhand smoke after implementation of smoke free legislation in wales a repeated cross sectional study children still exposed to secondhand smoke in spite of smoking ban welsh study finds fitness benefits and emergent division of labour at the onset of group living ant y social study of ants reveals the evolutionary benefits of group living genome wide association defines more than distinct susceptibility loci for crohn s disease complexity of crohn s disease revealed as gene count tops cannabis use and hypomania in young people a prospective analysis cannabis linked to bipolar symptoms in young adults vaccine induced protection from homologous tier shiv challenge in nonhuman primates depends on serum neutralizing antibody titers hiv vaccine protects non human primates from infection candidate microbial ichnofossils in continental basaltic tuffs of central oregon usa expanding the record of endolithic microborings microbes make tubular microtunnels on earth and perhaps on mars chameleons communicate with complex colour changes during contests different body regions convey different information chameleons use colorful language to communicate chameleons body regions are billboards for different types of information wearable thermocells based on gel electrolytes for the utilization of body heat wearable integrated thermocells based on gel electrolytes use body heat as power source juvenile concentrations of igf predict life history trade offs in a wild mammal hormone concentrations in young mammals predict trade offs later in life modeling motor neuron resilience in als using stem cells stem cells provide information about neuron resilience in als the macaque anterior cingulate cortex translates counterfactual choice value into actual behavioral change low intensity ultrasound can change decision making process in the brain presenilin knockin mice reveal loss of function mechanism for familial alzheimer s disease mechanism behind most common form of inherited alzheimer s disease revealed narrow band imaging as an alternative to chromoendoscopy for the detection of dysplasia in long standing inflammatory bowel disease a prospective randomized crossover study study compares narrow band imaging to chromoendoscopy for the detection of dysplasia in ibd patients biosensor zebrafish provide new insights into potential health effects of environmental estrogens green glowing fish provides new insights into health impacts of pollution promotion of plasma membrane repair by vitamin e scientists identify an innate function of vitamin e age adjusted d dimer cutoff for reducing ct pulmonary angiography tests in elderly patients with suspected pulmonary embolism new approach to diagnose blood clots in lungs of patients over the association between mandated preseason heat acclimatization guidelines and exertional heat illness during preseason high school american football practices mandatory pre season guidelines reduce heat illness among high school football players exome wide rare variant analysis identifies tuba a mutations associated with familial als new als associated gene identified using innovative strategy a new motor synergy that serves the needs of oculomotor and eye lid systems while keeping the downtime of vision minimal surprise discovery in the blink of an eye exploiting snps for biallelic crispr mutations in the outcrossing woody perennialpopulusreveals coumarate coa ligase specificity and redundancy researchers edit plant dna using mechanism evolved in bacteria increased incidence of inflammatory bowel disease in quebec residents with airway diseases high incidence of bowel disease seen in people with lung conditions direct formation of structural components using a martian soil simulant engineers investigate a simple no bake recipe to make bricks from martian soil cortical control of a tablet computer by people with paralysis brain computer interface enables people with paralysis to control tablet devices frontline science multiple cathepsins promote inflammasome independent particle induced cell death during nlrp dependent il activation new drug target for gout and other inflammatory diseases immune response to the hpv as adjuvanted vaccine administered as a dose or dose schedule up to years after vaccination results from a randomized study safety immunogenicity of two doses of the hpv as adjuvanted vaccine cervarix integrated multi cohort analysis identifies conserved transcriptional signatures across multiple respiratory viruses viral infections leave a signature on human immune system study finds characterization of a recombinant adeno associated virus type reference standard material novel reference material to standardize gene therapy applications short term costs of preeclampsia to the united states health care system preeclampsia new study documents its enormous economic and health burden alarm pheromone habituation in myzus persicae has fitness consequences and causes extensive gene expression changes fearless aphids ignore warnings get eaten by ladybugs similar effects of intranasal oxytocin administration and acute alcohol consumption on socio cognitions emotions and behaviour implications for the mechanisms of action the dark side of the love hormone similarities with the effects of alcohol the first definite lambeosaurine bone from the liscomb bonebed of the upper cretaceous prince creek formation alaska united states first confirmed occurrence of a lambeosaurine dinosaur found on alaska s north slope preclinical and clinical evidence of mycobacterium tuberculosis persistence in the hypoxic niche of bone marrow mesenchymal stem cells after therapy tuberculosis bacteria hide in low oxygen niches of bone marrow stem cells vertical deformation through a complete seismic cycle at isla santa mar a chile uplifted island the island isla santa mar a in south of central chile ionic dynamics mediate spontaneous termination of seizures and postictal depression state neuroscientists discovery could bring relief to epilepsy sufferers computational model of epileptic seizures at molecular level adjunctive risperidone treatment for antidepressant resistant symptoms of chronic military service related ptsd a randomized trial use of antipsychotics for reducing military related chronic ptsd symptoms does not appear effective oxygen generating biomaterials preserve skeletal muscle homeostasis under hypoxic and ischemic conditions oxygen generating compound shows promise for saving tissue after severe injury killing two birds with one stone oral tofacitinib reverses alopecia universalis in a patient with plaque psoriasis in hairless man arthritis drug spurs hair growth lots mandatory influenza vaccination of healthcare workers a year study infectious diseases experts call for mandatory flu vaccine for all health care personnel natural history of headache following traumatic brain injury headaches are common in year following traumatic brain injury especially among females hydro seq enables contamination free high throughput single cell rna sequencing for circulating tumor cells blood biopsy new technique enables detailed genetic analysis of cancer cells dose dependent expression of claudin is a modifying factor in schizophrenia major breakthrough identifies new mechanism for the development of schizophrenia endovascular therapy for acute ischemic stroke with occlusion of the middle cerebral artery m segment endovascular therapy potentially beneficial for distal stroke clots initiation of prostate cancer in mice by tp r h evidence for an alternative molecular progression new role for p genetic mutation initiation of prostate cancer the association between traumatic brain injury and adhd in a canadian adult sample study finds association between people who have had a traumatic brain injury adhd playing the field the effect of fertility on women s desire for variety women seek greater variety in men and consumer products near ovulation addition of carbonic anhydrase inhibitor slc to temozolomide treatment delays glioblastoma growth in vivo enzyme inhibitor combined with chemotherapy delays glioblastoma growth reproductive health outcomes in african refugee women a comparative study refugee women have healthier pregnancies than us women why ? an unhealthy us culture potent inhibition of heterotopic ossification by nuclear retinoic acid receptor agonists potential treatment found for debilitating bone disease in wounded soldiers and children women at extreme risk for obesity related carcinogenesis baseline endometrial pathology and impact of bariatric surgery on weight metabolic profiles and quality of life study finds dramatic benefits of weight loss surgery impact of advertisements promoting candy like flavoured e cigarettes on appeal of tobacco smoking amongst children an experimental study ads for candy flavored e cigarettes could encourage vaping among school children small cash incentives can encourage primary care visits by low income people with new health care coverage cash incentives talk can encourage primary care visits by people with new health coverage same sex and different sex parent households and child health outcomes findings from the national survey of children s health for kids raised in stable families no difference in well being with same sex versus different sex parents a recombinant mycobacterium smegmatis induces potent bactericidal immunity against mycobacterium tuberculosis potential vaccine readies immune system to kill tuberculosis in mice effect of oophorectomy on survival after breast cancer inbrca andbrca mutation carriers removal of ovaries associated with decrease in breast cancer death in women with cancer brca mutation high levels of both n and n long chain polyunsaturated fatty acids in cord serum phospholipids predict allergy development kids allergies may correlate with omega omega lipid levels in cord blood subliminal strengthening improving older individuals physical function over time with an implicit age stereotype intervention positive subliminal messages on aging improve physical functioning in elderly modeling the mitochondrial cardiomyopathy of barth syndrome with induced pluripotent stem cell and heart on chip technologies patient stem cells used to make heart disease on a chip effects of stx arbaclofen on neurobehavioral function in children and adults with fragile x syndrome a randomized controlled phase trial medication effective in treating social withdrawal in fragile x and potentially autism patients air propelled abrasive grits reduce weed abundance and increase yields in organic vegetable production weed blasting offers new control method for organic farmers lim kinases are required for invasive path generation by tumor and tumor associated stromal cells lim kinase plays a key role in cancer metastasis keratin dependent regulation of aire and gene expression in skin tumor keratinocytes skin cancer marker plays critical role in tumor growth evidence for a pan neurodegenerative disease response in huntington s and parkinson s disease expression profiles commonalities in brains of people with huntington s disease and parkinson s disease ccnd overexpression enhances the regenerative potency of human induced pluripotent stem cell derived cardiomyocytes remuscularization of injured ventricle saving hearts after heart attacks overexpression of a gene enhances repair of dead muscle cyclocreatine treatment improves cognition in mice with creatine transporter deficiency success reported in treating autism spectrum disorder in mice sound source localization inspired by the ears of the ormia ochracea fly inspired sound detector new device based on a fly s freakishly acute hearing for futuristic hearing aids combination treatment with n acetyl seryl aspartyl lysyl proline and tissue plasminogen activator provides potent neuroprotection in rats after stroke substance naturally found in humans effective in fighting brain damage from stroke retaliatory mafia behavior by a parasitic cowbird favors host acceptance of parasitic eggs female cowbirds pay attention to cowbird nestling survival study finds the shh receptor boc promotes progression of early medulloblastoma to advanced tumors discovery could prevent development of brain tumors in children beta integrin c met cooperation reveals an inside in survival signalling on autophagy related endomembranes unexpected findings reveal insight into how cancer spreads in the body crustose coralline algae increased framework and diversity on ancient coral reefs algae fortifies coral reefs in past and present associated risk factors for silent cerebral infarcts in sickle cell anemia low baseline hemoglobin gender and relative high systolic blood pressure silent stroke risk factors for children with sickle cell anemia initial micromorphological results from liang bua flores indonesia site formation processes and hominin activities at the type locality of homo floresiensis fire discovery sheds new light on hobbit demise some mathematical and geophysical considerations in radioisotope dating applications paper spotlights key flaw in widely used radioisotope dating technique the sky in edvard munch s the scream the scream what were those colorful wavy clouds in edvard munch s famous painting ? fine scale diversity and extensive recombination in a quasisexual bacterial population occupying a broad niche quasi sexual gene transfer drives genetic diversity of hot spring bacteria comprehensive suppression of single molecule conductance using destructive interference single molecular insulator pushes boundaries of current state of the art tobacco companies use of retailer incentives after a ban on point of sale tobacco displays in scotland tobacco industry steps up tactics to reduce impact of display ban the metabolic syndrome in children and adolescents shifting the focus to cardiometabolic risk factor clustering aap counsels pediatricians to focus on clusters of cardiometabolic risk factors to help obese kids thyroid function and the risk of atherosclerotic cardiovascular morbidity and mortality the rotterdam study higher thyroid hormone levels associated with artery disease and early death a new species of liolaemus related to l. nigroviridis from the andean highlands of central chile iguania liolaemidae the lizard of consistency new iguana species which sticks to its colors found in chile high flow nasal oxygen vs noninvasive positive airway pressure in hypoxemic patients after cardiothoracic surgery newer method of oxygen delivery for patients at risk of respiratory failure after surgery statin use and risk for cataract a nested case control study of populations in canada and the united states new study strengthens evidence of connection between statin use and cataracts any risks should be weighed against benefits nearly all the sky is covered by lyman emission around high redshift galaxies nearly the entire sky in the early universe is glowing with lyman alpha emission two year evaluation of mandatory bundled payments for joint replacement medicare s bundled payment experiment for joint replacements shows moderate savings chimpanzees routinely fish for algae with tools during the dry season in bakoun guinea new behavioral variant in wild chimpanzees algae fishing in bakoun guinea interactions between the tumor and the blood systemic response of breast cancer patients molecular fingerprint of breast tumors linked to immune response in bloodstream increased rates of bone fracture among hiv infected persons in the hiv outpatient study hops compared with the us general population hiv infected patients at higher risk for bone fractures autism and cancer share risk genes pathways and drug targets autism and cancer share a remarkable number of risk genes in common mismatch of school furniture and back pain in adolescents with different maturation levels most painful days of your life school desks and chronic back pain commensal dna limits regulatory t cell conversion and is a natural adjuvant of intestinal immune responses dna of good bacteria drives intestinal response to infection nutritional correlates of koala persistence in a low density population koalas selective about eucalyptus leaves at mealtime koalas selected leaves with more nitrogen fewer toxins community integrated omics links dominance of a microbial generalist to fine tuned resource usage microbial communities for health and environment precise measurements of microbial ecosystems a comprehensive genomic history of extinct and living elephants complete genomes of extinct and living elephants sequenced deceleration of high velocity interstellar photon sails into bound orbits at centauri space travel visionaries solve the problem of interstellar slowdown at our stellar neighbor change in prevalence of hearing loss in us adolescents prevalence of hearing loss among us adolescents has increased significantly study finds creation of rydberg polarons in a bose gas exotic state of matter an atom full of atoms maternal inheritance of a recessive rbp defect in canine congenital eye disease blame the mother s gene discovery for a blinding canine eye disease the nanoscale geometrical maturation of focal adhesions controls stem cell differentiation and mechano transduction stem cells a soft touch for nano engineered biomaterials fertility and prenatal attitudes towards pregnancy in women with eating disorders results from the avon longitudinal study of parents and children research into eating disorders and fertility reveals mixed picture cancer risks associated with germline mutations in mlh msh and msh genes in lynch syndrome study identifies genetic mutations associated with cancer risk for hereditary cancer syndrome the weng an biota doushantuo formation an ediacaran window on soft bodied and multicellular microorganisms new light shed on world s oldest animal fossils b vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice b vitamin deficiency may cause vascular cognitive impairment post vietnam military herbicide exposures in uc agent orange spray aircraft air force aircraft returned from vietnam identified as postwar source of agent orange contamination combined antioxidant and glucocorticoid therapy for safer treatment of preterm birth premature babies could benefit from combined glucocorticoid and antioxidant therapy the genomics of invasion characterization of red lionfish pterois volitans populations from the native and introduced ranges lionfish genes studied for clues to invasive prowess one third of global protected land is under intense human pressure shocking study shows one third of world s protected areas degraded by human activities neural stem cells rescue cognitive and motor dysfunction in a transgenic model of dementia with lewy bodies through a bdnf dependent mechanism stem cell treatment lessens impairments caused by dementia with lewy bodies emissions from electronic cigarettes assessing vapers intake of toxic compounds secondhand exposures and the associated health impacts exposure to toxins in e cig vapor varies depending on scenario a single dose live attenuated vaccine prevents zika virus pregnancy transmission and testis damage potential zika vaccine protects against pregnancy transmission and testicular damage uncovering exposures responsible for birth season disease effects a global study global birth season study links environment with disease risk increased methylation variation in epigenetic domains across cancer types scientists expose cancer cells universal dark matter findings reveal chaos in biochemical alterations of cancer cells optimizing cholesterol treatment in patients with muscle complaints strategies to optimize statin treatment for muscle symptoms creative style and achievement in adults with attention deficit hyperactivity disorder adults with attention deficit hyperactivity disorder score high in creativity metabolomic analysis of insulin resistance across different mouse strains and diets pre diabetes discovery marks step towards precision medicine seven decades of mountain hare counts show severe declines where high yield recreational game bird hunting is practised severe declines of mountain hares on scottish grouse moors c ebp mediates nicotinamide enhanced clearance of staphylococcus aureus in mice vitamin b may offer new tool in fight against staph infections superbugs understanding tobacco industry pricing strategy and whether it undermines tobacco tax policy the example of the uk cigarette market tobacco companies keep people smoking despite uk cigarette tax increases extended follow up confirms early vaccine enhanced risk of hiv acquisition and demonstrates waning effect over time among participants in a randomized trial of recombinant adenovirus hiv vaccine step study early elevated hiv infection risk in some step study participants who received vaccine risk decreased over time increasing demand for natural rubber necessitates a robust sustainability initiative to mitigate impacts on tropical biodiversity expanding rubber plantations catastrophic for endangered species in southeast asia selective depletion of mutant p by cancer chemopreventive isothiocyanates and their structure activity relationships discovery of a biochemical basis for broccoli s cancer fighting ability maternal intake of high n polyunsaturated fatty acid diet during pregnancy causes transgenerational increase in mammary cancer risk in mice high fat diet in pregnancy increases breast cancer risk over generations in animal study a cngb frameshift mutation in papillon and phal ne dogs with progressive retinal atrophy new pra gene identified in dogs phalenes and papillons knowledge of autism spectrum disorder among college students in health care disciplines autism awareness among future healthcare workers still has room for improvement the end of the cold loneliness d comparison between doto antarctica and a new sympatric species of doto heterobranchia nudibranchia new marine invertebrate species in weddell sea antarctica community calcification in lizard island great barrier reef a year perspective effect of ocean acidification coral growth rate on great barrier reef plummets in year comparison separation of craniopagus twins by a multidisciplinary team high tech tools teamwork were key to separating infant girls joined at the head annexin enriched osteoblast derived vesicles act as an extracellular site of mineral nucleation within developing stem cell cultures new method for tissue regeneration inspired by nature neutrophils and natural killer t cells as negative regulators of wound healing experimental approach may improve healing of diabetic wounds and bed sores bleaching drives collapse in reef carbonate budgets and reef growth potential on southern maldives reefs impacts of mass coral die off on indian ocean reefs revealed association between anticholinergic medication use and cognition brain metabolism and brain atrophy in cognitively normal older adults brain scans link physical changes to cognitive risks of widely used class of drugs association of medical and adult use marijuana laws with opioid prescribing for medicaid enrollees relationship between legal cannabis and opioid prescribing examined adverse effects of exposure to armed conflict on pregnancy a systematic review living in a war zone linked to delivery of low birthweight babies the environment as a driver of immune and endocrine responses in dolphins tursiops truncatus environment defined as an influencer of immune system responses in dolphins preservation of acyl coa attenuates pathological and metabolic cardiac remodeling through selective lipid trafficking scientists id new metabolic target to prevent treat heart failure at earliest stage transplanted human stem cell derived interneuron precursors mitigate mouse bladder dysfunction and central neuropathic pain after spinal cord injury human stem cells treat spinal cord injury side effects in mice genetic identification of c fibres that detect massage like stroking of hairy skin in vivo sorting out stroking sensations biologists find individual neurons in skin that react to massage confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo new tool in the early detection of bowel disease walking away hurt walking around scared a cluster analysis of violence exposure among young black males violence among young black men associated with sense of powerlessness study finds the emergence of population health in us academic medicine population health a rapidly evolving discipline in us academic medicine epithelial bridges maintain tissue integrity during collective cell migration new discovery on how skin cells form bridges paves the way for advances in wound healing and tissue engineering phenotypic distribution models corroborate species distribution models a shift in the role and prevalence of a dominant prairie grass in response to climate change climate change predicted to reduce size stature of dominant midwest plant study finds neanderthal and woolly mammoth molecular resemblance genetic similarities may underlie cold adaptation suite woolly mammoths and neanderthals may have shared genetic traits hiv prevention efforts and incidence of hiv in uganda combination hiv prevention reduces new infections by percent in ugandan district maternal vitamin d status in pregnancy is associated with adiposity in the offspring findings from the southampton women s survey children s body fat linked to vitamin d insufficiency in mothers randomized clinical trial of portion controlled prepackaged foods to promote weight loss prepackaged portion controlled meals can lead to greater weight loss than self selected portions research says heart rate reduction by ivabradine reduces diastolic dysfunction and cardiac fibrosis a heart rate reducing medication reduces the risk of heart failure and cardiac fibrosis histamine as an emergent indoor contaminant accumulation and persistence in bed bug infested homes bed bug histamines are substantial persistent in infested homes the archaeology of shea butter vitellaria paradoxa in burkina faso west africa production of butter from shea trees in west africa pushed back years sleep modulation alleviates axonal damage and cognitive decline after rodent traumatic brain injury enhancing sleep after brain injury reduces brain damage cognitive decline in rats neural decoding of treadmill walking from non invasive electroencephalographic eeg signals brain cap technology turns thought into motion mind machine interface could lead to new life changing technologies for millions of people structure of the human cgas dna complex reveals enhanced control of immune surveillance structure and key features of critical immune surveillance protein in humans the lingering impact of stress brief acute glucocorticoid exposure has sustained dose dependent effects on reproduction tree swallow study stressful events have long term health impacts global reductions in seafloor biomass in response to climate change major reductions in seafloor marine life from climate change by diatom bloom derived biotoxins cause aberrant development and gene expression in the appendicularian chordate oikopleura dioica marine algae bloom derived biotoxins alter development of zooplankton and ocean food web inhibiting the osteocyte specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma promising new therapeutic approach for debilitating bone disease combined impact of lifestyle related factors on total and cause specific mortality among chinese women prospective cohort study benefits of healthy lifestyle factors stronger in combination a dedicated network for social interaction processing in the primate brain newly discovered brain network offers clues to social cognition anticipating spring wild populations of great tits parus major differ in expression of key genes for photoperiodic time measurement wild birds respond differently to the first long days of a year implementation of prescription drug monitoring programs associated with reductions in opioid related death rates drug monitoring programs reduce opioid deaths study shows enhancement of ultrahigh rate chargeability by interfacial nanodot batio treatment on licoo cathode thin film batteries elucidation of structural property in li ion batteries that deliver ultra fast charging the early effects of external and internal strategies on working memory updating training one month worth of memory training results in minutes the impact of different types of parental support behaviours on child physical activity healthy eating and screen time a cross sectional study direct and active parent involvement key to healthy living for kids the impact of fiscal austerity on suicide mortality evidence across the eurozone periphery male suicide on rise as result of austerity report suggests trophoblast inclusions are significantly increased in the placentas of children in families at risk for autism autism risk spotted at birth in abnormal placentas recurrent de novo mutations affecting residue arg of pyrroline carboxylate synthase cause a progeroid form of autosomal dominant cutis laxa p cs mutations identified as new target for skin rejuvenation direct evidence of the presence of cross linked a dimers in the brains of alzheimer s disease patients beta amyloid dimers found in brains of patients with alzheimer s the systematics of the worldwide endoparasite family apodanthaceae cucurbitales with a key a map and color photos of most species putting the endoparasitic plants apodanthaceae on the map topographical functional connectivity patterns exist in the congenitally prelingually deaf the architecture of audition study shows auditory cortex of hearing deaf people are nearly identical impact of antenatal steroids on intraventricular hemorrhage in very low birth weight infants prenatal steroids reduce risk of brain bleeding in preemies stanford study finds variability in retail pricing of generic drugs for heart failure wide variability in generic heart failure drugs can make them unaffordable to uninsured patients transcriptomic analysis of autistic brain reveals convergent molecular pathology autism changes molecular structure of the brain discovery points to a common cause for multifaceted disease dnmt is essential for mammary and cancer stem cell maintenance and tumorigenesis gene found that is essential to maintaining breast and cancer stem cells a conserved role for serotonergic neurotransmission in mediating social behavior in octopus octopuses given mood drug ecstasy reveal genetic link to evolution of social behaviors in humans mental well being and changes in peer ability from high school to college making a leap from high ability high school to college of lesser academic status can be a real downer control of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type a botox makes unnerving journey into our nervous system protein aggregation and protein instability govern familial amyotrophic lateral sclerosis patient survival protein plays jekyll and hyde role in lou gehrig s disease ocean acidification affects coral growth by reducing skeletal density scientists pinpoint how ocean acidification weakens coral skeletons congenital zika syndrome with arthrogryposis retrospective case series study study provides details of possible link between zika severe joint condition at birth colorless multifunctional coatings inspired by polyphenols found in tea chocolate and wine sticking power of plant polyphenols used in new coatings apatite microtopographies instruct signaling tapestries for progenitor driven new attachment of teeth technique to reattach teeth using stem cells developed fundamental differences in promoter cpg island dna hypermethylation between human cancer and genetically engineered mouse models of cancer fundamental differences found between human cancers genetically engineered mouse models troubled waters risk perception and the case of oyster restoration in the closed waters of the hudson raritan estuary study offers pearls of wisdom in contested new york oyster restoration evaluation of the safety of rituximab in combination with a tumor necrosis factor inhibitor and methotrexate in patients with active rheumatoid arthritis results from a randomized controlled trial rituximab combined with a tnf inhibitor and methotrexate shows no safety signal in rheumatoid arthritis treatment study finds borniopsis mortoni sp. n. heterodonta galeommatoidea galeommatidae sensu lato a new bivalve commensal with a synaptid sea cucumber from japan living together in mud new bivalve species dwelling on a sea cucumber discovered in japan precision assessment of heterogeneity of lymphedema phenotype genotypes and risk prediction researchers study patients genetic and susceptibility risk factors for lymphedema cardiovascular screening in college athletes with and without electrocardiography a cross sectional study adding ecg to health exams may prevent sudden cardiac death in young athletes type i ifns mediate development of postinfluenza bacterial pneumonia in mice the immune response to influenza virus isn t all good emulating bilingual synaptic response using a junction based artificial synaptic device hacking the human brain lab made synapses for artificial intelligence extended main sequence turn off originating from a broad range of stellar rotational velocities aging a flock of stars in the wild duck cluster comparison within pairs promotes analogical abstraction in three month olds three month old infants can learn abstract relations before language comprehension experimental treatment with favipiravir for ebola virus disease the jiki trial a historically controlled single arm proof of concept trial in guinea nuanced findings for a large experimental treatment trial for ebola virus disease global burden of sugar related dental diseases in countries and corresponding health care costs high sugar consumption gives rise to dental treatment costs in the billions higher brain bdnf gene expression is associated with slower cognitive decline in older adults growth factor in brain tied to slower mental decline frequency and anatomical distribution of magnetic resonance imaging features in sacroiliac joints of young athletes exploring background noise towards a data driven definition of sacroiliitis in early spondyloarthritis bone marrow edema in lower spine is common in young athletes metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation power up growing neurons undergo major metabolic shift choir singing and creative writing enhance emotion regulation in adults with chronic mental health conditions arts based groups benefit individuals with mental health conditions shadows a spectro gonio radiometer for bidirectional reflectance studies of dark meteorites and terrestrial analogs design calibrations and performances on challenging surfaces instrument boosts analysis of small extremely dark materials all optical spiking neurosynaptic networks with self learning capabilities step towards light based brain like computing chip implanted passive engineering mechanism improves hand function after tendon transfer surgery a cadaver based study mechanized human hands system designed to improve hand function lost to nerve damage pulmonary dysfunction in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem cell transplantation safeguarding lungs of young cancer survivors research findings underscore needed action cardioprotective effects of lcz sacubitril valsartan after experimental acute myocardial infarction new drug protects heart from cardiac rupture after myocardial infarction impact of thermal treatments on the bioaccessibility of phytoene and phytofluene in relation to changes in the microstructure and size of orange juice particles deep freezing of orange juice can increase the absorption of beneficial compounds large scale replication study reveals a limit on probabilistic prediction in language comprehension large scale replication study challenges key evidence for the pro active reading brain collapse of the winter beaufort high a response to thinning sea ice ? wind sea ice patterns point to climate change in western arctic a preoperative risk model for postoperative pneumonia after coronary artery bypass grafting hospital data helps predict risk of pneumonia after heart surgery pediatric concussion biomechanical differences between outcomes of transient and persistent weeks postconcussion symptoms biomechanical analysis of head injury in pediatric patients effect of the garrett lee smith memorial suicide prevention program on suicide attempts among youths suicide prevention program associated with reduction in suicide attempts the obesity epidemic and rising diabetes incidence in a low income racially diverse southern us cohort rising obesity rates in us south leading to rapid increase in diabetes cases ionic modulation and ionic coupling effects in mos devices for neuromorphic computing toward brain like computing new memristor better mimics synapses topological non hermitian origin of surface maxwell waves physicists uncover the topological origin of surface electromagnetic waves environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism study demonstrates rapid decline in male dog fertility with potential link to environmental contaminants chronic wasting disease drives population decline of white tailed deer first ever evidence of white tailed deer declines from chronic wasting disease child and adult outcomes of chronic child maltreatment chronic child abuse strong indicator of negative adult experiences the association of previous revascularization with in hospital outcomes in acute myocardial infarction patients treatment time lags for heart attack patients with prior bypass graft surgery enclaves of genetic diversity resisted inca impacts on population history genetics preserves traces of ancient resistance to inca rule no more fomo limiting social media decreases loneliness and depression social media use increases depression and loneliness study finds eye protection and risk of eye injuries in high school field hockey protective eyewear reduces field hockey eye injuries without increased concussion risk white matter correlates of cognitive dysfunction after mild traumatic brain injury even mild traumatic brain injury may cause brain damage schroth physiotherapeutic scoliosis specific exercises added to the standard of care lead to better cobb angle outcomes in adolescents with idiopathic scoliosis an assessor and statistician blinded randomized controlled trial specialized physical therapy helps teens with scoliosis get ahead of the curve the effect of false positive mammograms on antidepressant and anxiolytic initiation false positive mammogram results linked to spike in anxiety prescriptions the dallas fort worth airport earthquake sequence seismicity beyond injection period earthquakes continue for years after gas field wastewater injection stops study finds a multiproduct network economic model of cybercrime in financial services new model of cybercrime factors in perishability of stolen data preferential epigenetic programming of estrogen response after in utero xenoestrogen bisphenol a exposure fetal bpa exposure in mice linked to estrogen related diseases after adolescence a multisite study of the clinical diagnosis of different autism spectrum disorders multi site study finds wide variation in best estimate clinical diagnosis of autism spectrum disorders the long term impact of systemic student support in elementary school reducing high school dropout elementary school student support leads to lower high school dropout study finds tropical rabbitfish and the deforestation of a warming temperate sea tropical rabbitfish a threat to mediterranean sea ecosystems a longitudinal study of resting heart rate and violent criminality in more than men association of low resting heart rate in men increased violent criminality risk of head and traumatic brain injuries associated with antidepressant use among community dwelling persons with alzheimer s disease a nationwide matched cohort study antidepressant use increases risk of head injuries among persons with alzheimer s disease fluctuations in depression and well being are associated with sexual risk episodes among hiv positive men. happy people safer sex good moods lead to safer sexual behavior in gay men host directed therapy of tuberculosis based on interleukin and type i interferon crosstalk proof of concept for host directed tuberculosis therapy established by researchers noncanonical effects of irf in intestinal inflammation more than type i and type iii interferons for a good gut feeling scientists explore molecular signals in inflammatory bowel disease gut microbiota from twins discordant for obesity modulate metabolism in mice human gut microbes alter mouse metabolism depending on diet impact of climate change on new york city s coastal flood hazard increasing flood heights from the preindustrial to ce sea level rise not stronger storm surge will cause future nyc flooding private provision of public goods by environmental groups economic analysis provides watershed moment for environmental groups impacts of climate change and water resources development on the declining inflow into iran s urmia lake climate human influence conspired in lake urmia s decline warming impacts on boreal fen co exchange under wet and dry conditions climate change impacts peatland co gas exchange primarily via moisture conditions naturalistic follow up of youths treated for pediatric anxiety disorders less than half of children treated for anxiety achieve long term relief the aging brain care medical home preliminary data novel population health management program yields major health improvement feature article from the cover an rnai based chemical genetic screen identifies three small molecule inhibitors of the wnt wingless signaling pathway small molecules inhibit growth of human tumor cells the uneven nature of daily precipitation and its change half of the world s annual precipitation falls in just days randomized controlled trial of a cognitive behavioral therapy plus hypnosis intervention to control fatigue in patients undergoing radiotherapy for breast cancer hypnosis therapy shown to decrease fatigue levels in breast cancer patients long noncoding rna linp regulates repair of dna double strand breaks in triple negative breast cancer long noncoding rna regulates repair of dna breaks in triple negative breast cancer cells short term peripheral nerve stimulation ameliorates axonal dysfunction after spinal cord injury electrical nerve stimulation can reverse spinal cord injury nerve damage in patients increased incidence rate of trauma and stressor related disorders in denmark following the breivik attacks in norway breivik terrorist attacks in norway led to mental illness in denmark structural basis for hijacking of cellular lxxll motifs by papillomavirus e oncoproteins cervical cancer first d image of an hpv oncoprotein intrinsic ribosome destabilization underlies translation and provides an organism with a strategy of environmental sensing protein intentionally terminates own synthesis by destabilizing synthesis machinery the ribosome four year outcome of randomly assigned lifestyle treatments in primary care of children with obesity good help in primary care for children with obesity sofosbuvir and ribavirin for hepatitis c genotype in patients with unfavorable treatment characteristics a randomized clinical trial investigational oral regimen for hepatitis c shows promise effect of omega fatty acids lutein zeaxanthin or other nutrient supplementation on cognitive function the areds randomized clinical trial no benefit of omega supplements for cognitive decline study shows antiproliferative alkaloids from alangium longiflorum an endangered tropical plant species bioactive novel compounds from endangered tropical plant species profound tissue specificity in proliferation control underlies cancer drivers and aneuploidy patterns startlingly different tissue sensitivities to cancer driving genes sunny rainy and cloudy with a chance of mobile promotion effectiveness sunny rainy or cloudy new study shows how weather impacts response to mobile ads managed metapopulations do salmon hatchery sources lead to in river sinks in conservation ? hatchery fish mask the decline of wild salmon populations early childhood stress exposure reward pathways and adult decision making high stress childhoods blind adults to potential loss anti interleukin monoclonal antibody to treat severe eosinophilic asthma researchers improve severe asthma care through new antibody based treatment why does a mature volcano need new vents ? the case of the new southeast crater at etna one vent just isn t enough for some volcanoes curious case of mount etna s wandering craters extremely abundant antimicrobial peptides existed in the skins of nine kinds of chinese odorous frogs stinky frogs are a treasure trove of antibiotic substances singing fish rely on circadian rhythm and melatonin for the timing of nocturnal courtship vocalization melatonin biological clock keep singing fish on time systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis the new epoc randomised controlled trial unexpected results in cancer drug trial combination of cetuximab chemo had negative results prediagnostic sex steroid hormones in relation to male breast cancer risk men with high estrogen levels could be at greater risk of breast cancer the ribosomal rpl r s mutation drives ires dependent bcl translation in t all t cell leukemia cancer cells take advantage of survival protein a hybrid continuous discrete time model for invasion dynamics of zebra mussels in rivers modeling invasive activity zebra mussels infiltration of north american rivers oral immunotherapy with inactivated nthi reduces severity of acute exacerbations in severe copd oral vaccine may reduce exacerbations in patients with copd lipid corona formation from nanoparticle interactions with bilayers insight into how nanoparticles interact with biological systems more rapid increase in bmi from age is associated with elevated weight status at age among non hispanic white females high childhood bmi linked to obesity at age in women statin medications may prevent dementia and memory loss with longer use while not posing any short term cognition problems statin may prevent dementia memory loss with longer use don t pose short term cognition problems targeting the opioid growth factor opioid growth factor receptor axis for treatment of human ovarian cancer successful treatment of triple negative breast cancer by modulation of the ogf ogfr axis global imprint of climate change on marine life global investigation reveals true scale of ocean warming species changing breeding times shifting homes hydrogen sulfide increases hepatic differentiation in tooth pulp stem cells dental pulp stem cells transformed by bad breath chemical thermal energy and stress properties as the main drivers of regional distribution of coral species richness in the indian ocean scientists discover balance of thermal energy and low climate stress drive coral species diversity potential impact of national school nutritional environment policies small fraction of students attended schools with usda nutrition components impact of coronary artery calcium scanning on coronary risk factors and downstream testing the eisner early identification of subclinical atherosclerosis by noninvasive imaging research prospective randomized trial coronary artery calcium scans may help lower heart disease risk without increasing tests and costs historical changes in american self interest state of the union addresses to state of the nation s egotism on the rise for a century analysis finds human gut on a chip inhabited by microbial flora that experiences intestinal peristalsis like motions and flow living human gut on a chip tiny device simulates structure microenvironment and mechanical behavior of human intestine acceptance of bats to gates at abandoned mines do bats adapt to gates at abandoned mines ? the effect of tai chi on four chronic conditions cancer osteoarthritis heart failure and chronic obstructive pulmonary disease a systematic review and meta analyses tai chi linked to improved physical capacity in certain common long term conditions climate change and frog calls long term correlations along a tropical altitudinal gradient climate change likely culprit in coqui frog s altered calls say biologists perioperative outcomes and oncologic efficacy from a pilot prospective randomized clinical trial of open versus robotic assisted radical cystectomy robotic assisted radical bladder surgery potentially benefits bladder cancer patients anomalous mantle transition zone beneath the yellowstone hotspot track yellowstone super volcano eruptions were produced by gigantic ancient oceanic plate study finds vhl deletion in osteoblasts boosts cellular glycolysis and improves global glucose metabolism heavy bones low body weight new link between bone cells and blood sugar level found del restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates study blocks inflammatory bone loss in gum disease channelopathy as a sudep biomarker in dravet syndrome patient derived cardiac myocytes heart abnormalities may trigger sudden unexplained death in epilepsy a natural rice rhizospheric bacterium abates arsenic accumulation in rice oryza sativa l. microbe mobilizes iron shield to block arsenic uptake in rice transcriptome analysis of the planarian eye identifies ovo as a specific regulator of eye regeneration planarians offer a better view of eye development outcome of whole exome sequencing for diagnostic odyssey cases of an individualized medicine clinic whole exome sequencing rational approach for diagnostic odyssey patients endoreduplication of the mouse genome in the absence of orc unlocking the secrets of cell division in cancer dextromethorphan and quinidine for treating agitation in patients with alzheimer disease dementia combination drug treatment reduces agitation for patients with probable alzheimer s disease comparative genetic analysis of inflammatory bowel disease and type diabetes implicates multiple loci with opposite effects genes may exert opposite effects in diabetes and inflammatory bowel disease perinatal exposure of mice to the pesticide ddt impairs energy expenditure and metabolism in adult female offspring pesticide ddt linked to slow metabolism obesity and diabetes mouse study finds chronic administration of an hdac inhibitor treats both neurological and systemic niemann pick type c disease in a mouse model new formulation of fda approved drug may help treat niemann pick type c disease antidepressant use and risk of hip fractures among community dwelling persons with and without alzheimer s disease antidepressant use increases hip fracture risk among elderly superresolution imaging reveals nanometer and micrometer scale spatial distributions of t cell receptors in lymph nodes super resolution microscopy reveals unprecedented detail of immune cells surface living alongside more affluent neighbors predicts greater involvement in antisocial behavior among low income boys low income boys fare worse in wealth s shadow the t cell antigen receptor transmembrane domain coordinates triggering through regulation of bilayer immersion and cd subunit associations key parts of mechanism for activating t cells to fight cancer and other diseases plasmodium products persist in the bone marrow and promote chronic bone loss bone loss is another hidden pathology caused by malaria infection predictors for long term seizure outcome in juvenile myoclonic epilepsy years of follow up seizure freedom reported in of juvenile myoclonic epilepsy patients ocean impact on decadal atlantic climate variability revealed by sea level observations global climate on verge of multi decadal change a network pharmacology approach reveals new calorie restriction mimetic drugs in c. elegans face cream ingredient found to mimic life extending effects of a calorie restriction diet dietary antigens limit mucosal immunity by inducing regulatory t cells in the small intestine typical food triggers creation of regulatory t cells prevalence of alcohol interactive prescription medication use among current drinkers united states to exploring the use of alcohol interactive prescription medication among us drinkers ebola virus disease implications for solid organ transplantation simple steps can safeguard against ebola transmission through organ donation a sucrose enriched diet promotes tumorigenesis in mammary gland in part through the lipoxygenase pathway sugars in western diets increase risk for breast cancer tumors and metastasis prenatal catenin brn tbr transcriptional cascade regulates adult social and stereotypic behaviors newly identified pathway links fetal brain development to adult social behavior predicting treatment seekers readiness to change their drinking behavior in the combine study motivational readiness for alcohol drug treatment is more about self evaluation than consequences long term decline in survival and reproduction of dolphins following a marine heatwave climate change is a threat to dolphins survival chronic social stress induced hyperglycemia in mice couples individual stress susceptibility to impaired spatial memory individual stress susceptibility and glucose metabolism are linked to brain function race dependent association of sulfidogenic bacteria with colorectal cancer study links sulfide producing bacteria and colon cancer in african americans an ectomycorrhizal nitrogen economy facilitates monodominance in a neotropical forest fungi are at the root of tropical forest diversity or lack thereof study finds is unhealthy substance use associated with failure to receive cancer screening and flu vaccination ? a retrospective cross sectional study unhealthy substance use a risk factor for not receiving some preventive health services study finds multiple processes drive genetic structure of humpback whale megaptera novaeangliae populations across spatial scales massive genetic study of humpback whales to inform conservation assessments milky way cepheid standards for measuring cosmic distances and application to gaia dr implications for the hubble constant hubble and gaia team up to fuel cosmic conundrum mechanistic basis of organization of the harmonin ush c mediated brush border microvilli tip link complex did ear sensory cell stereocilia evolve from gut microvilli ? a compartmentalized microfluidic chip with crisscross microgrooves and electrophysiological electrodes for modeling the blood retinal barrier scientists emulate the human blood retinal barrier on a microfluidic chip predictors of phrase and fluent speech in children with autism and severe language delay speech emerges in children on the autism spectrum with severe language delay at greater rate than previously thought cntf gene therapy confers lifelong neuroprotection in a mouse model of human retinitis pigmentosa gene therapy gives long term protection to photoreceptor cells presynaptic inhibition of spinal sensory feedback ensures smooth movement spinal cord neurons that control skilled limb movement identified transcatheter closure of patent ductus arteriosus in extremely premature newborns new nonsurgical repair of the most common heart defect found in extremely premature newborns shown to be effective prevalence of sexually transmitted infection human immunodeficiency virus counseling services received by teen males sexually transmitted infections hiv counseling inadequate in male teens study finds preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys antibodies halt placental transmission of cmv like virus in monkeys paternal overweight is associated with increased breast cancer risk in daughters in a mouse model in mice daughters of overweight dads have altered breast tissue higher cancer risk forebrain gabaergic neuron precursors integrate into adult spinal cord and reduce injury induced neuropathic pain chronic pain is relieved by cell transplantation in lab study giant spin oscillations in an ultracold fermi sea viewing macro behaviors of ultra cold quantum gases through the micro world temporal transcriptional logic of dynamic regulatory networks underlying nitrogen signaling and use in plants biologists identify temporal logic of regulatory genes affecting nitrogen use efficiency in plants effects of mva a vaccine on tuberculosis challenge in animals systematic review effects of mva a vaccine on tuberculosis challenge in animals whole genome sequencing of turbot scophthalmus maximus pleuronectiformes a fish adapted to demersal life the turbot vertebrate genes give clues into disease resistance chemotherapy decisions and patient experience with the recurrence score assay for early stage breast cancer precision medicine test helps guide breast cancer patients chemotherapy decision mitochondrial localization import and mitochondrial function of the androgen receptor androgen receptor treatment target for prostate cancer imports into mitochondria a polyploid admixed origin of beer yeasts derived from european and asian wine populations modern beer yeast emerged from mix of european grape wine asian rice wine yeast pandemic h n vaccine protects against spanish influenza virus h n vaccine protects against influenza virus cross protection helps alleviate bioterrorism concerns media use and sleep among boys with autism spectrum disorder adhd or typical development screens in the bedroom may contribute to sleep problems in boys with autism cancer incidence in a sample of maryland residents with serious mental illness cancer and injuries more likely in people with serious mental illness evaluation of effective groundwater recharge of freshwater lens in small islands by the combined modeling of geoelectrical data and water heads small islands in the pacific duel between freshwater and sea water optic vesicle like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment progress using induced pluripotent stem cells to reverse blindness hepatic gene expression related to lower plasma cholesterol in hamsters fed high fat diets supplemented with blueberry peels and peel extract blueberry s effects on cholesterol examined in lab animal study using d printed eggs to examine the egg rejection behaviour of wild birds one to ovoid ? using d printing researchers can study what causes birds to reject eggs with greater precision and repeatability use of bone morphogenetic proteins in spinal fusion surgery for older adults with lumbar stenosis sharp rise in use of bone growth factor for spinal fusion surgery whole genome sequencing and imputation in isolated populations identify genetic associations with medically relevant complex traits isolated greek villages reveal genetic secrets that protect against heart disease omega and omega oxylipins are implicated in soybean oil induced obesity in mice gm soybean oil causes less obesity and insulin resistance but is harmful to liver function left ventricular dysfunction after degenerative mitral valve repair a question of better molecular targets or better surgical timing ? new study questions timing in mitral valve repairs high male sexual investment as a driver of extinction in fossil ostracods new driver of extinction adaptations for sexual selection comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder systematic review and meta analysis no treatment difference between some antidepressants and cbt for severe depression senescence associated secretory phenotypes reveal cell nonautonomous functions of oncogenic ras and the p tumor suppressor escape cancer but age sooner ? the dark side of the tumor suppressing process oncogene aeg promotes glioma induced neurodegeneration by increasing glutamate excitotoxicity mechanism in brain cancer responsible for neuron death discovered transglutaminase is essential for adherence of porphyromonas gingivalis to host cells protein plays key role in infection by oral pathogen relationship between adverse effects of antiepileptic drugs number of coprescribed drugs and drug load in a large cohort of consecutive patients with drug refractory epilepsy adverse drug effects in epileptic patients not correlated with number of prescribed medications study shows massive landslide at utah copper mine generates wealth of geophysical data mine landslide triggered earthquakes record breaking slide would bury central park feet deep hospital level under utilization of minimally invasive surgery in the united states retrospective review minimally invasive surgery underused at many u.s. hospitals silver nanoparticles in therapeutics development of an antimicrobial gel formulation for topical use new silver nanoparticle skin gel for healing burns humans thrived in south africa through the toba eruption about years ago modern humans flourished through ancient supervolcano eruption years ago origin of apparent light enhanced and negative capacitance in perovskite solar cells mystery of negative capacitance in perovskite solar cells solved hiv drug resistance emergence among breastfeeding infants born to hiv infected mothers during a single arm trial of triple antiretroviral prophylaxis for prevention of mother to child transmission a secondary analysis prevention of mother child transmission programs work but infants need checking for drug resistance study suggests association of admission to veterans affairs hospitals vs non veterans affairs hospitals with mortality and readmission rates among older men hospitalized with acute myocardial infarction heart failure or pneumonia study compares outcomes at va hospitals vs. non va hospitals sympathomimetic effects of acute e cigarette use role of nicotine and non nicotine constituents one e cigarette with nicotine leads to adrenaline changes in nonsmokers hearts origin of the hiv group o epidemic in western lowland gorillas gorilla origins of the last two aids virus lineages confirmed music in our ears the biological bases of musical timbre perception music in our ears the science of timbre a comprehensive investigation of mesophotic coral ecosystems in the hawaiian archipelago extensive deep coral reefs in hawaii harbor unique species and high coral cover longitudinal findings from a norwegian case cohort study on internalizing problems in children with congenital heart defects doubled risk of anxiety for month old children with congenital heart defects health professional beliefs knowledge and concerns surrounding medicinal cannabis a systematic review health professionals wary of medicinal cannabis misuse and adverse effects proteasome dysfunction triggers activation of skn a nrf by the aspartic protease ddi researchers identify key elements of cellular response to proteasome dysfunction a mildly relativistic wide angle outflow in the neutron star merger event gw radio observations point to likely explanation for neutron star merger phenomena gwas of longitudinal amyloid accumulation on f florbetapir pet in alzheimer s disease implicates microglial activation geneil rap newfound gene linked to amyloid beta plaque buildup in alzheimer s disease crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia cells in normal tissue seem to have personal space issues factor in maintaining healthy tissue evidence of chronic kidney disease in veterans with incident diabetes mellitus many patients show signs of chronic kidney disease before diabetes diagnosis tropical forest wood production a cross continental comparison super charged tropical trees borneo s productive trees vitally important for global carbon cycling severe bereavement stress during the prenatal and childhood periods and risk of psychosis in later life population based cohort study losing a family member in childhood associated with psychotic illness current child but not maternal snoring is bi directionally related to adiposity and cardiometabolic risk markers a cross sectional and a prospective cohort analysis like a baby the vicious cycle of childhood obesity and snoring why e cigarettes are dividing the public health community investigation examines bitter dispute over e cigarettes in the public health community widespread reductions in cortical thickness following severe early life deprivation a neurodevelopmental pathway to attention deficit hyperactivity disorder institutional rearing may increase risk for attention deficit disorder by altering cortical development reflection imaging of china ink perfused brain vasculature using confocal laser scanning microscopy after clarification of brain tissue by the spalteholz method innovative technique to examine blood vessels in d help unlock secrets of the brain association of secondhand smoke exposure with pediatric invasive bacterial disease and bacterial carriage a systematic review and meta analysis second hand smoke increases risk of invasive meningococcal disease in children consumption of red and processed meat and breast cancer incidence a systematic review and meta analysis of prospective studies processed meat consumption linked to breast cancer risk discovery of the development candidate n tert butyl nodulisporamide a safe and efficacious once monthly oral agent for the control of fleas and ticks on companion animals once a month pill for both fleas and ticks in dogs and cats fin whale movements in the gulf of california mexico from satellite telemetry far ranging fin whales find year round residence in gulf of california mothers strategies to strengthen their daughters body image mothers use variety of strategies to mitigate risks to daughters body image increasing importance of precipitation variability on global livestock grazing lands global grazing lands increasingly vulnerable to a changing climate the stress response neuropeptide crf increases amyloid production by regulating secretase activity some evidence of link between stress alzheimer s disease discovered sun induced chlorophyll fluorescence photosynthesis and light use efficiency of a soybean field scientists monitor crop photosynthesis performance using invisible light genetic predisposition to breast cancer due to mutations other than brca and brca founder alleles among ashkenazi jewish women genetic predisposition to breast cancer due to non brca mutations in ashkenazi jewish women the profound reach of the m. april indian ocean earthquake short term global triggering followed by a longer term global shadow after major earthquake silence dynamic stressing of a global system of faults results in rare seismic silence comparison of prescription drug costs in the united states and the united kingdom part antibiotics in young children cost of antibiotic drugs for children comparison of two countries hemoglobin a c and fasting plasma glucose levels as predictors of retinopathy at years the french desir study blood glucose levels that predict year risk of retinopathy identified dynamic response of antarctic peninsula ice sheet to potential collapse of larsen c and george vi ice shelves expected sea level rise following antarctic ice shelves collapse oral bacterial signatures in cerebral thrombi of patients with acute ischemic stroke treated with thrombectomy presence of oral bacteria in cerebral emboli of stroke patients the potential of indigenous agricultural food production under climate change in hawai i indigenous agriculture has potential to contribute to food needs under climate change coccolithophore calcification response to past ocean acidification and climate change ancient marine algae provides clues of climate change impact on today s microscopic ocean organisms model for individualized prediction of breast cancer risk after a benign breast biopsy new breast cancer risk prediction model more accurate than current model prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children population based case control study early exposure to pesticides linked to small increased risk of autism spectrum disorder obesity accelerates alzheimer related pathology in apoe but not apoe mice western diet increases alzheimer s pathology in genetically predisposed mice deshaciendo el palimpsesto una aproximaci n a la secuencia cultural de la ocupaci n neandertal del abrigo de navalma llo pinilla del valle espa a new study on neanderthal occupations in the sierra de madrid labor market returns to an early childhood stimulation intervention in jamaica early childhood programs yield long term gains for children in developing nations management of eustachian tube dysfunction with nasal steroid spray a prospective randomized placebo controlled trial nasal steroid spray may not help resolve dysfunction of the ear s eustachian tubes a novel enolpyruvoylshikimate phosphate epsp synthase transgene for glyphosate resistance stimulates growth and fecundity in weedy rice oryza sativa without herbicide modifying rice crops to resist herbicide prompts weedy neighbors growth spurt microbial life on a sand grain from bulk sediment to single grains a single sand grain harbors up to microorganisms from thousands of species phase safety pharmacokinetics and fluorescence imaging study of tozuleristide blz in adults with newly diagnosed or recurrent gliomas new brain tumor imaging technique uses protein found in scorpion venom the hr a debris system discovery of extensive exo ring dust material hubble finds huge system of dusty material enveloping the young star hr a epilepsy surgery for pharmacoresistant temporal lobe epilepsy a decision analysis analysis supports use of surgery to treat medication resistant epilepsy zscan is activated after telomere shortening in mouse embryonic stem cells rejuvenation factor zscan is expressed in response to telomere shortening risk assessment of h n influenza viruses from the avian reservoir s pandemic influenza virus remains a health threat particularly to those under purpose in life and its relationship to all cause mortality and cardiovascular events sense of purpose in life linked to lower mortality and cardiovascular risk histone deacetylases suppress cgg repeat induced neurodegeneration via transcriptional silencing in models of fragile x tremor ataxia syndrome researchers discover way to block neurodegeneration in an adult form of fragile x syndrome socioeconomic inequalities in adolescent health a time series analysis of countries participating in the health behaviour in school aged children study widening health inequalities among adolescents international study reveals reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation universal antidote for snakebite experimental trial represents promising step toward evaluation of calorie density and feeding directions for commercially available diets designed for weight loss in dogs and cats wide variation in calorie content among low calorie pet foods impairment of park dependent ca signalling is a novel determinant of parkinson s disease researchers discover novel factor in parkinson s disease minimally invasive mitral valve surgery provides excellent outcomes without increased cost a multi institutional analysis minimally invasive mitral valve surgery offers viable option for select heart patients rapid and inefficient kinetics of sickle hemoglobin fiber growth most precise measurements of sickle cell disease building blocks could lead to new treatments the detection of hot cores and complex organic molecules in the large magellanic cloud stellar embryos in nearby dwarf galaxy contain surprisingly complex organic molecules effect of dapagliflozin on heart failure and mortality in type diabetes mellitus diabetes drug effective against heart failure in wide spectrum of patients virusdetect an automated pipeline for efficient virus discovery using deep sequencing of small rnas virusdetect a new bioinformatics pipeline for virus identification released engagement alignment and rigor as vital signs of high quality instruction a classroom visit protocol for instructional improvement and research vital signs of teaching captured by quick reliable in class evaluation recommendations for preventing fracture in long term care new guideline aims to reduce fractures in seniors in long term care facilities gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase pck expression and histone modification in neonatal offspring rats high fat diet during pregnancy programs child for future diabetes study suggests structural insights into yeast telomerase recruitment to telomeres scientists create a d model of molecules in yeast linked to enzyme that lengthens chromosome tips endovascular stroke treatment outcomes after patient selection based on magnetic resonance imaging and clinical criteria mri based screening improves assignment of stroke patients to endovascular treatment roa rumsfeldi a new butterflyfish teleostei chaetodontidae from mesophotic coral ecosystems of the philippines surprise new butterflyfish from the philippine twilight zone transcriptional elongation of hsv immediate early genes by the super elongation complex drives lytic infection and reactivation from latency understanding of herpesvirus infection advanced by new research managing perceptions of distress at work reframing emotion as passion having a meltdown at work ? blame it on your passion impact of prescription drug monitoring programs and pill mill laws on high risk opioid prescribers a comparative interrupted time series analysis florida drug database and pill mills curbed state s top opioid prescribers the proteasome inhibitor bortezomib drastically affects inflammation and bone disease in adjuvant induced arthritis in rats proteasome inhibitor reduces inflammation and promotes bone healing in arthritis models efficacy and effectiveness of an rvsv vectored vaccine expressing ebola surface glycoprotein interim results from the guinea ring vaccination cluster randomised trial ebola vaccine efficacy trial suggest vaccine provides high protection against disease chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge rapid and durable protection against ebola virus with new vaccine regimens zika virus infection with prolonged maternal viremia and fetal brain abnormalities link between zika virus and fetal brain damage confirmed subambient cooling of water toward real world applications of daytime radiative cooling low cost energy saving radiative cooling system ready for real world applications accelerated evolution in distinctive species reveals candidate elements for clinically relevant traits including mutation and cancer resistance mapping the genome jungle unique animal traits could offer insight into human disease blue boron bearing diamonds from earth s lower mantle what makes diamonds blue ? boron from oceanic crustal remnants in earth s lower mantle the spirodela polyrhiza genome reveals insights into its neotenous reduction fast growth and aquatic lifestyle pond dwelling powerhouse s genome points to biofuel potential cognitive behavioral therapy vs relaxation with educational support for medication treated adults with adhd and persistent symptoms cognitive behavior therapy improves symptom control in adult adhd colored glasses to mitigate photophobia symptoms posttraumatic brain injury colored glasses may provide light sensitivity relief post concussion stress associated erythropoiesis initiation is regulated by type conventional dendritic cells baffling lab mystery leads to potential new anemia treatment acetylcholine synthesizing t cells relay neural signals in a vagus nerve circuit t cells making brain chemicals may lead to better treatments for inflammation autoimmune diseases an insight into the use and assessment of lower limb running prostheses in sport with a disability a mixed method approach research proposes new test on prosthetic legs in competitive sports the state of inpatient psychiatry for youth in ontario results of the oncaips benchmarking survey gaps in inpatient psychiatry for ontario youth study concludes lymphotoxin receptor controls t cell progenitor entry to the thymus researchers identify possible pathway to reboot immune system after bone marrow transplants neonatal dna methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors subject to tissue specific influence differences between human twins at birth highlight importance of intrauterine environment knowledge of driving vehicle licensing agency guidelines among nhs doctors a multicentre observational study low awareness of dvla safe driving guidelines among hospital doctors chronic stress increases vulnerability to diet related abdominal fat oxidative stress and metabolic risk chronic stress heightens vulnerability to diet related metabolic risk association of a novel diagnostic biomarker the plasma cardiac bridging integrator score with heart failure with preserved ejection fraction and cardiovascular hospitalization biomarker discovered for most common form of heart failure association of body mass index and outcomes in patients with metastatic melanoma treated with targeted therapy immunotherapy or chemotherapy a retrospective multicohort analysis obesity associated with longer survival for men with metastatic melanoma wild type microglia arrest pathology in a mouse model of rett syndrome new studies contradict earlier findings on rett syndrome environmental drivers of a microbial genomic transition zone in the ocean s interior new gene catalog of ocean microbiome reveals surprises human embryonic stem cell derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation human stem cells repair damage caused by radiation therapy for brain cancer in rats structural bases of noncompetitive inhibition of ampa subtype ionotropic glutamate receptors by antiepileptic drugs new epilepsy drugs work by jamming brain receptor remnant foreskin contains fewer langerhans cells implications for human immunodeficiency virus transmission in circumcised men adult circumcision reduces risk of hiv transmission without reducing sexual pleasure basal p expression is indispensable for mesenchymal stem cell integrity gene responsible for mesenchymal stem cells stem ness identified the burden of glory competing for nonmonetary incentives in rank order tournaments workers may choke under pressure of non monetary incentives head to head comparison of certolizumab pegol versus adalimumab in rheumatoid arthritis year effi cacy and safety results from the randomised exxelerate study rheumatoid arthritis drugs direct switch has a beneficial effect a soft wearable microfluidic device for the capture storage and colorimetric sensing of sweat soft microfluidic lab on the skin developed for sweat analysis vitamin d receptor mediated skewed differentiation of macrophages initiates myelofibrosis and subsequent osteosclerosis vitamin d and immune cells stimulate bone marrow disease engagement in vocational activities promotes behavioral development for adults with autism spectrum disorders employment may lead to improvement in autism symptoms chronic systemic therapy with low dose morpholino oligomers ameliorates the pathology and normalizes locomotor behavior in mdx mice duchenne muscular dystrophy scientists closer to finding treatment for life threatening hereditary disease eu sanitary regulation on livestock disposal implications for the diet of wolves mad cow disease changed the diet of the galician wolf the antimicrobial potential of streptomyces from insect microbiomes microbes hitched to insects provide a rich source of new antibiotics liquid like behavior of uv irradiated interstellar ice analog at low temperatures uv irradiated amorphous ice behaves like liquid at low temperatures vanin expression and methylation discriminate pediatric asthma corticosteroid treatment response genetic variance explains poor response to common asthma medications a mediterranean diet enriched with olive oil is associated with higher serum total osteocalcin levels in elderly men at high cardiovascular risk mediterranean diet enriched with olive oil may protect bone prevalence of housing problems among community health center patients housing problems found to be common at safety net community health centers mixed pathologies including chronic traumatic encephalopathy account for dementia in retired association football soccer players evidence of brain damage found in former soccer players a mathematical descriptor of tumor mesoscopic structure from computed tomography images annotates prognostic and molecular phenotypes of epithelial ovarian cancer artificial intelligence can predict survival of ovarian cancer patients evidence for a pulsar wind nebula in the type ib peculiar supernova sn au astronomers witness birth of new star from stellar explosion inhibition of fast axonal transport by pathogenic sod involves activation of p map kinase jammed molecular motors may play a role in the development of als statins normalize vascular lysyl oxidase down regulation induced by proatherogenic risk factors cardiovascular health statins normalize vascular lysyl oxidase down regulation adolescent intermittent alcohol exposure persistence of structural and functional hippocampal abnormalities into adulthood your adolescent brain on alcohol changes last into adulthood higher bone resorption excretion in south asian women vs. white caucasians and increased bone loss with higher seasonal cycling of vitamin d results from the d fines cohort study potential early warning signs of osteoporosis found in south asian women effectiveness of folic acid supplementation in pregnancy on reducing the risk of small for gestational age neonates a population study systematic review and meta analysis new study examines effect of timing of folic acid supplementation during pregnancy brain mr imaging findings and associated outcomes in carriers of the reciprocal copy number variation at p.. mri reveals striking brain differences in people with genetic autism steroid use in lyme disease associated facial palsy is associated with worse long term outcomes corticosteroid use linked to worse outcomes for patients with lyme disease associated facial paralysis effect of abnormal screening mammogram on quality of life women with false positive mammograms report high anxiety and reduced quality of life the strategic targeting of females by transnational tobacco companies in south korea following trade liberalisation tobacco companies target girls in south korea research shows genes with aberrant expression in murine preneoplastic intestine show epigenetic and expression changes in normal mucosa of colon cancer patients biomarkers could lead to early diagnosis of colorectal cancer active sampling device for determining pollutants in surface and pore water the in situ sampler for biphasic water monitoring innovative device traces chemicals affecting human and environmental health tai chi exercise in patients with chronic heart failure a randomized clinical trial tai chi appears to benefit quality of life for patients with chronic heart failure study finds photoexcited quantum dots for killing multidrug resistant bacteria light activated nanoparticles prove effective against antibiotic resistant superbugs strategies for successful management of severe atopic dermatitis researchers raise bar for successful management of severe atopic dermatitis low grade chronic inflammation in pregnant women with polycystic ovary syndrome a prospective controlled clinical study polycystic ovary syndrome diagnosis tied to inflammation during pregnancy transcaval access and closure for transcatheter aortic valve replacement a prospective investigation new method for performing aortic valve replacement proves successful in high risk patients some medical inpatients with unhealthy alcohol use may benefit from brief intervention researchers find medical inpatients with unhealthy alcohol use may benefit from brief intervention discovery of f n diethylamino ethyl fluoronicotinamide a melanoma positron emission tomography imaging radiotracer with high tumor to body contrast ratio and rapid renal clearance potential new imaging agent for early diagnosis of most serious skin cancer a candida albicans crispr system permits genetic engineering of essential genes and gene families crispr cas genome editing of candida albicans holds promise for overcoming deadly fungal infections new horned dinosaurs from utah provide evidence for intracontinental dinosaur endemism amazing horned dinosaurs unearthed on lost continent new discoveries include bizarre beast with horns fusion of regionally specified hpsc derived organoids models human brain development and interneuron migration lab created mini brains reveal how growing organ maintains neuronal balance controlling the coherence of a diamond spin qubit through its strain environment tunable diamond string may hold key to quantum memory the clinical research office of the endourological society croes multicentre randomised trial of narrow band imaging assisted transurethral resection of bladder tumour turbt versus conventional white light imaging assisted turbt in primary narrow band imaging can reduce recurrence of bladder tumors sustainable seafood ecolabeling and awareness initiatives in the context of inland fisheries increasing food security and protecting ecosystems awareness and labeling initiatives can benefit inland fisheries electronic cigarette use among college students links to gender race ethnicity smoking and heavy drinking e cigarette use among college students helpful aid or risky enabler ? intestinal microbiota determine severity of myocardial infarction in rats the microbiome and disease gut bacteria influence the severity of heart attacks in rats er stress induced mediator c ebp homologous protein thwarts effector t cell activity in tumors through t bet repression one way t cell function may fail in cancer characterization of meningeal type innate lymphocytes and their response to cns injury powerful defenders of the brain discovered with big implications for disease and injury clinical and patient centered outcomes in obese type diabetes patients years after randomization to roux en y gastric bypass surgery versus intensive lifestyle management the slimm t d study gastric bypass surgery can give better control for diabetes and obesity than lifestyle modification transplantation dose alters the differentiation program of hematopoietic stem cells dose of transplanted blood forming stem cells affects their behavior association between germline mutations in brf a subunit of the rna polymerase iii transcription complex and hereditary colorectal cancer a new genetic marker accounts for up to. percent of cases of hereditary colon cancer golf a contact sport. repetitive traumatic discopathy may be the driver of early lumbar degeneration in modern era golfers how a golf swing can lead to early lumbar degeneration dietary and microbial oxazoles induce intestinal inflammation by modulating aryl hydrocarbon receptor responses chance discovery links inflammatory bowel disease with common bacterial gut toxin somatosensory brainstem thalamus and cortex of the california sea lion zalophus californianus scientists establish first map of the sea lion brain computational models can predict response to hiv therapy without a genotype and may reduce treatment failure in different resource limited settings computer models predict how patients will respond to hiv drugs without the need for resistance testing whole organism lineage tracing by combinatorial and cumulative genome editing new genetic barcode technique reveals details of cell lineage climate change and water in southwestern north america special feature a year perspective of st century drought in southwestern north america hot with decades of drought expectations for southwestern united states prevalence of twin foaling and blood chimaerism in purebred spanish horses the prevalence of twin births in pure spanish horses stroke legislation impacts distribution of certified stroke centers in the united states state stroke legislation increases u.s. primary stroke centers ultra high mobility transparent organic thin film transistors grown by an off centre spin coating method engineers make world s fastest organic transistor herald new generation of see through electronics hypothalamic inhibition of socio sexual behaviour by increasing neuroestrogen synthesis discovery of mechanism by which sex hormone regulates aggressive behavior in male birds how honeybees defy gravity with royal jelly to raise queens how royal jelly helps honeybee larvae defy gravity and become queens trajectories of physical discipline early childhood antecedents and developmental outcomes parental physical discipline through childhood linked to behavior problems in teens aerobic exercise but not resistance exercise reduces intrahepatic lipid content and visceral fat and improves insulin sensitivity in obese adolescent girls for obese teen girls aerobic exercise may trump resistance training in health benefits extreme spectral richness in the eye of the common bluebottle butterfly graphium sarpedon fifteen shades of photoreceptor in a butterfly s eye effect of an intravitreal antisense oligonucleotide on vision in leber congenital amaurosis due to a photoreceptor cilium defect injection improves vision in a form of childhood blindness chronic nicotine activates stress reward related brain regions and facilitates the transition to compulsive alcohol drinking nicotine use increases compulsive alcohol consumption study finds ant workers exhibit specialization and memory during raft formation all ants on deck raft building ants exhibit memory repeatedly occupy same position when forming rafts use of smokeless tobacco and risk of myocardial infarction and stroke systematic review with meta analysis smokeless tobacco increases risk of heart attack and stroke research finds prevalence of and risk factors for diabetic macular edema in the united states prevalence risk factors for diabetic macular edema explored in study tildrakizumab versus placebo or etanercept for chronic plaque psoriasis resurface and resurface results from two randomised controlled phase trials promising new treatment option for chronic plaque psoriasis metagenome assembled genomes uncover a global brackish microbiome closest relatives of baltic sea plankton are found in brackish north american waters protective efficacy of recombinant modified vaccinia virus ankara mva delivering middle east respiratory syndrome coronavirus spike glycoprotein mers coronavirus candidate vaccine gears up for clinical trials eighteenth century genomes show that mixed infections were common at time of peak tuberculosis in europe mummified bodies reveal how tuberculosis ravaged the heart of th century europe susceptibility to tuberculosis is associated with tlr polymorphisms resulting in a lack of tlr cell surface expression new discovery brings customized tuberculosis therapies based on genotype closer to reality the role of gender in mental illness stigma a national experiment his and hers role of gender in the stigma of mental illness examined severe pandemic h n influenza disease due to pathogenic immune complexes over reactive immune system kills young adults during pandemic flu a national profile of end of life caregiving in the united states caregiving needs increase as older adults approach the end of life inverse association for diagnosis of alzheimer s disease subsequent to both melanoma and non melanoma skin cancers in a large urban single centre midwestern us patient population skin cancers linked with reduced risk of alzheimer s disease epigenetic attenuation of mitochondrial superoxide dismutase sod in pulmonary arterial hypertension a basis for excessive cell proliferation and a new therapeutic target epigenetic gene silencing may hold key to fatal lung vascular disease microbial communities in marine sediments modify success of an invasive macrophyte tiny fighters in sediments determine success of invasive marine plants clinical practice guidelines by the infectious diseases society of america update on diagnosis treatment chemoprophylaxis and institutional outbreak management of seasonal influenzaa flu is serious for pregnant women and others at high risk stair a generic and fully automated method to fuse multiple sources of optical satellite data to generate a high resolution daily and cloud gap free surface reflectance product new algorithm fuses quality and quantity in satellite imagery scared to death ? generalized anxiety disorder and cardiovascular events in patients with stable coronary heart disease the heart and soul study heart patients with anxiety disorder experience more cardiovascular events deaths buy coal ! a case for supply side environmental policy buy coal ? new analysis shows purchasing fossil fuel deposits best way to fight climate change combining phylogenetic and occurrence information for risk assessment of pest and pathogen interactions with host plants new tool predicts risk of plant disease and infestation worldwide isoform selective phosphoinositide kinase inhibition ameliorates a broad range of fragile x syndrome associated deficits in a mouse model fragile x new drug strategy corrects behavior biochemical measures in mouse model evolution of the earliest horses driven by climate change in the paleocene eocene thermal maximum earliest horses show past global warming affected body size of mammals association of football subconcussive head impacts with ocular near point of convergence repetitive subconcussive head impacts from football associated with short term changes in eye function age dependent specific changes in area ca of the hippocampus and social memory deficit in a mouse model of the q. deletion syndrome loss of cells in brain s memory center linked to schizophrenia apple polyphenols require t cells to ameliorate dextran sulfate sodium induced colitis and dampen proinflammatory cytokine expression scientists discover anti inflammatory polyphenols in apple peels surgery for hip fracture yields societal benefits that exceed the direct medical costs surgery to repair hip fracture reduces lifetime health care costs by more than per patient spin alignment of stars in old open clusters starquakes reveal surprises about birth of stars in our galaxy lc gabaraps drive ubiquitin independent recruitment of optineurin and ndp to amplify mitophagy teaching human cells to clean house to delay aging and fight neurodegeneration altered metabolism of gut microbiota contributes to chronic immune activation in hiv infected individuals how the altered intestinal bacterial community worsens health in hiv infected patients juvenile traumatic brain injury increases alcohol consumption and reward in female mice in females childhood head injury could lead to alcohol abuse later in life biosynthesis of a fluorescent protein with extreme pseudo stokes shift by introducing a genetically encoded non natural amino acid outside the fluorophore synthetic biology novel kind of fluorescent protein developed association between clinician computer use and communication with patients in safety net clinics level of computer use in clinical encounters associated with patient satisfaction rapamycin normalizes serum leptin by alleviating obesity and reducing leptin synthesis in aged rats existing drug used in transplants causes older rats to lose weight diminutive fleet footed tyrannosauroid narrows the million year gap in the north american fossil record new species of tiny tyrannosaur foreshadows rise of t. rex annual report to the nation shows continuing decline in cancer mortality us cancer death rates in decline annual report focuses on brain tumors platelet derived s family member myeloid related protein regulates thrombosis heart attack gene mrp triggers blood clot formation statins promote the regression of atherosclerosis via activation of the ccr dependent emigration pathway in macrophages cholesterol lowering medication accelerates depletion of plaque in arteries structural magnetic resonance imaging in bipolar disorder an international collaborative mega analysis of individual adult patient data treatment for manic depressive illness restores brain volume deficits caiman an open source tool for scalable calcium imaging data analysis open source software tracks neural activity in real time arbuscular mycorrhiza specific enzymes fatm and ram fine tune lipid biosynthesis to promote development of arbuscular mycorrhiza feeding fat to fungi evidence for lipid transfer in arbuscular mycorrhiza a novel fer fert targeting compound selectively evokes metabolic stress and necrotic death in malignant cells cancer new compound targets energy generation thereby killing metastatic cells dynamic cell behavior on shape memory polymer substrates shape memory polymers shed light on how cells respond to physical environment light to moderate intake of alcohol drinking patterns and risk of cancer results from two prospective us cohort studies light moderate drinking linked to increased risk of some cancers in women male smokers tuber brennemanii and tuber floridanum two new tuber species are among the most commonly detected ectomycorrhizal taxa within commercial pecan carya illinoinensis orchards two new truffle species discovered in florida pecan orchards advancing research diagnostic criteria for alzheimer s disease the iwg criteria alzheimer s disease simplified diagnosis with more reliable criteria a framework for evaluating ecosystem services provided by cover crops in agroecosystems true value of cover crops to farmers environment altered urothelial atp signalling in major subset of human overactive bladder patients with pyuria researchers identify bacterial infection as a possible cause of bladder condition life long implications of developmental exposure to environmental stressors new perspectives parents preconception exposure to environmental stressors can disrupt early development transmissable dog cancer genome reveals the origin and history of an ancient cell lineage genome of longest living cancer year old living dog cancer reveals its origin evolution the accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children prospective cohort study of febrile illnesses computer model better than clinical judgment for diagnosing fever in young children long term outcomes of group b streptococcal meningitis group b streptococcal meningitis has long term effects on children s developmental outcomes regulatory t cells are not a strong predictor of survival for patients with glioblastoma research finds no correlation between regulatory t cells and survival in glioblastoma ema an orally administered highly selective angiotensin ii type receptor antagonist as a novel treatment for postherpetic neuralgia a randomised double blind placebo controlled phase clinical trial new drug treatment reduces chronic pain following shingles impact of the seven valent pneumococcal conjugate vaccination pcv programme on childhood hospital admissions for bacterial pneumonia and empyema in england national time trends study vaccine has cut child cases of bacterial pneumonia says study derivation and validation of a scoring system to stratify risk for advanced colorectal neoplasia in asymptomatic adults new risk score for colorectal cancer could guide selection of screening tests soxc transcription factors are essential for the development of the inner ear study of inner ear development hints at way to restore hearing and balance low gestational weight gain skews human sex ratios towards females low weight gain in pregnant women reduces male fetal survival candidate gene biodosimetry markers of exposure to external ionizing radiation in human blood a systematic review preparing for quick radiation diagnostic test in case of a nuclear disaster frequent utilization of the emergency department for acute heart failure syndrome a population based study repeat emergency department visits for acute heart failure suggest need for better outpatient care development of the canadian syncope risk score to predict serious adverse events after emergency department assessment of syncope new screening tool to help physicians tell if a fainting episode heralds something serious an adaptable but threatened big cat density diet and prey selection of the indochinese leopard panthera pardus delacouri in eastern cambodia cambodia s last leopards on brink of extinction self figure drawings in women with anorexia bulimia overweight and normal weight a possible tool for assessment women with eating disorders draw a different picture of themselves than women without study suggests sustained high prevalence of sexually transmitted infections among female sex workers in cambodia high turnover seriously challenges the condom use programme inexperienced prostitutes most at risk of sexual infections warming accelerates mangrove expansion and surface elevation gain in a subtropical wetland mangrove expansion and climatic warming may help ecosystems keep pace with sea level rise forward genetics identifies a requirement for the izumo like immunoglobulin superfamily spe gene in caenorhabditis elegans fertilization shared genetics in humans roundworms shed light on infertility study finds systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts imbalanced gut microbiome linked to systemic sclerosis study suggests silk fibroin scaffolds promote formation of theex vivoniche for salivary gland epithelial cell growth matrix formation and retention of differentiated function scientists silk structure is secret to process of regenerating salivary cells nicotine decreases food intake through activation of pomc neurons nicotine triggered appetite suppression site identified in brain multiple stimulus presentation yields larger deficits in children with developmental dyslexia a study with reading and ran type tasks naming tests study on dyslexic versus average children elemental characterisation of melanin in feathers via synchrotron x ray imaging and absorption spectroscopy in bird feathers scientists find hints about color of extinct animals prevalence of cardiovascular risk factors in an urban adult population from southern spain. imap study alarmingly high cardiovascular risk factors found in mediterranean people measuring the impact of ebola control measures in sierra leone ebola treatment beds prevented ebola cases deaths in sierra leone preadmission use of statins and outcomes after hospitalization with pneumonia population based cohort study of patients statins associated with lower risk of death from pneumonia hybrid inorganic organic capsules for efficient intracellular delivery of novel sirnas against influenza a h n virus infection novel drug delivery beats swine flu at gene level widespread sex differences in gene expression and splicing in the adult human brain different gene expression in male female brains may help explain brain disorder differences what difference does a century make ? shifts in the ecosystem structure of the ross sea antarctica as evidenced from a sentinel species the weddell seal century old seal pelts reveal changes in ross sea ecosystem are born to rebel last borns more likely to be self employed ? youngest siblings more likely to go into business study finds rescue of hearing and vestibular function by antisense oligonucleotides in a mouse model of human deafness researchers develop rx for deafness impaired balance in mouse model of usher syndrome epigenetic stability of exhausted t cells limits durability of reinvigoration by pd blockade stability of exhausted t cells limits durability of cancer checkpoint drugs fatal anaphylaxis in the united states temporal patterns and demographic associations medications are main culprit of allergic deaths in u.s. comprehensive study finds sheet secondary structure in amyloid peptide drives aggregation and toxicity in alzheimer s disease synthetic peptide can inhibit toxicity aggregation of protein in alzheimer s disease rational approach to guest confinement inside mof cavities for low temperature catalysis scientists squeeze catalysts inside host materials like a ship into a bottle blood pressure and incidence of twelve cardiovascular diseases lifetime risks healthy life years lost and age specific associations in million people systolic diastolic blood pressures predict risk of different cardiovascular diseases altered gradients of glutamate and gamma aminobutyric acid transcripts in the cortical visuospatial working memory network in schizophrenia postmortem schizophrenia study identifies shifts in patterns of glutamate and gaba in visuospatial working memory network plio pleistocene decline of african megaherbivores no evidence for ancient hominin impacts human ancestors not to blame for ancient mammal extinctions in africa ocean warming slows coral growth in the central red sea global warming slows coral growth in red sea telemedicine guided remote enrollment of patients into an acute stroke trial telemedicine enrolls patients remotely into acute stroke trial yoga meditation and mind body health increased bdnf cortisol awakening response and altered inflammatory marker expression after a month yoga and meditation retreat yoga and meditation improve mind body health and stress resilience intestinal alkaline phosphatase prevents metabolic syndrome in mice adding intestinal enzyme to diets of mice appears to prevent treat metabolic syndrome exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy genetic testing in epilepsy takes more than one gene dual purpose hafnium oxide nanoparticles offer imaging streptococcus mutans dental biofilm and fight it in vivo via a drug free approach novel nanoparticle based approach detects and treats oral plaque without drugs prenatal maternal stress predicts autism traits in year old children project ice storm prenatal maternal stress predicts asthma and autism traits in year old children nicoya earthquake rupture anticipated by geodetic measurement of the locked plate interface scientists anticipated size and location of costa rica earthquake is the physician s behavior in dyslipidemia diagnosis in accordance with guidelines ? cross sectional escarval study clinical inertia precludes proper diagnosis in up to lipid abnormalities unraveling the pathophysiology of the asthma copd overlap syndrome exploring clinical conundrum of asthma copd overlap in nonsmokers with chronic asthma sildenafil treatment of women with antidepressant associated sexual dysfunction a randomized controlled trial viagra works for antidepressant related sexual dysfunction in women study suggests update on bone anchored hearing aids in pediatric patients with profound unilateral sensorineural hearing loss bone anchored hearing aids help youth with single sided deafness sds page analysis of a oligomers is disserving research into alzheimer s disease appealing for esi im ms study challenges scientific principle about alzheimer protein amyloid beta transience of mhc class i restricted antigen presentation after influenza a virus infection human vaccine against bird flu within reach with new discovery bigger is fitter ? quantitative genetic decomposition of selection reveals an adaptive evolutionary decline of body mass in a wild rodent population early onset of winter triggers evolution towards smaller snow voles in graub nden neural computations mediating one shot learning in the human brain switching on one shot learning in the brain first record of the miocene hominoid sivapithecus from kutch gujarat state western india late miocene ape maxilla upper jaw discovered in western india growth charts for children with down syndrome in the united states new growth charts developed for us children with down syndrome genome of the asian longhorned beetle anoplophora glabripennis a globally significant invasive species reveals key functional and evolutionary innovations at the beetle plant interface genomic tools to combat the spread of the invasive asian longhorned beetle influence of glial derived matrix molecules especially chondroitin sulfates on neurite growth and survival of cultured mouse embryonic motoneurons sugar residues regulate growth and survival of nerve cells cherax snowden a new species of crayfish crustacea decapoda parastacidae from the kepala burung vogelkop peninsula in irian jaya west papua indonesia new indonesian crayfish species escapes the decor market to become a freedom fighter restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia patient stem cells used to make dementia in a dish help identify new treatment strategy garlic sprouting is associated with increased antioxidant activity and concomitant changes in the metabolite profile don t throw out old sprouting garlic it has heart healthy antioxidants the influence of metallicity on stellar differential rotation and magnetic activity special star is a rosetta stone for understanding the sun s variability and climate effect herpes zoster vaccine in older adults and the risk of subsequent herpes zoster disease zoster vaccine associated with lower risk of shingles in older adults perinatal antidepressant exposure alters cortical network function in rodents perinatal antidepressant stunts brain development in rats miswired brain circuitry traced to early exposure caesarean delivery and risk of childhood leukaemia a pooled analysis from the childhood leukemia international consortium clic potential association between pre labor cesarean delivery and childhood leukemia ided cognitive training interventions for patients with alzheimer s disease a systematic review benefits of cognitive training in dementia patients unclear introduction guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine updated guidelines covering fusion procedures for degenerative disease of the lumbar spine mode load and specific climate impact from passenger trips planes trains or automobiles travel choices for a smaller carbon footprint mild traumatic brain injury in uk military personnel returning from afghanistan and iraq high rates and impact of traumatic brain injury in iraq afghanistan veterans uncertainty in soil data can outweigh climate impact signals in global crop yield simulations better soil data key for future food security sex dependent insulin like growth factor expression in preattachment equine embryos survival of the females horse embryo study provides important new information the moderating effects of sex and age on the association between traumatic brain injury and harmful psychological correlates among adolescents boys girls who ve had a traumatic brain injury differ in rates of harmful behavior the mental and physical health consequences of changes in private insurance before and after early retirement loss of employer based health insurance in early retirement affects mental physical health transcriptional pausing and stalling causes multiple clustered mutations by human activation induced deaminase evolution in action our antibodies take evolutionary leaps to fight microbes low and high birth weights are risk factors for nonalcoholic fatty liver disease in children birth weight is risk factor for fatty liver disease in children repeated commit or defer decisions with a deadline the influenza vaccine composition new decision model seeks to avert flu vaccine mismatch of season rapid pulsed light sintering of silver nanowires on woven polyester for personal thermal management with enhanced performance durability and cost effectiveness an energy efficient way to stay warm sew high tech heating patches to your clothes meta analysis of individuals identifies susceptibility loci for migraine large scale genetic study provides new insight into the causes of migraine mothers experiences expressing breast milk for their preterm infants privacy a problem for mothers of newborns in neonatal intensive care units the development of inhibitory control in early childhood a twin study from years. by age environmental factors are relevant to the development of self control abundance changes and habitat availability drive species responses to climate change population stability hope in species response to climate change telipogon diabolicus orchidaceae oncidiinae a new species from southern colombia orchid or demon flower of a new species of orchid looks like a devil s head genotypes of predomestic horses match phenotypes painted in paleolithic works of cave art ancient dna provides new insights into cave paintings of horses fault controlled hydration of the upper mantle during continental rifting faults control the amount of water flowing into the earth during continental breakup endoscopic stricturotomy with needle knife in the treatment of strictures from inflammatory bowel disease first endoscopic stricturotomy with needle knife study for intestinal strictures in ibd rational hiv immunogen design to target specific germline b cell receptors new vaccine design approach targets viruses such as hiv electrical image of passive mantle upwelling beneath the northern east pacific rise scientists image deep magma beneath pacific seafloor volcano millennial scale changes in atmospheric co levels linked to the southern ocean carbon isotope gradient and dust flux rapid climate change and the role of the southern ocean association of patient age at gastric bypass surgery with long term all cause and cause specific mortality gastric bypass surgery at ages older than years associated with improved survival ews fli confers tumor cell synthetic lethality to cdk inhibition in ewing sarcoma cancer researchers hit a bullseye with new drug target for ewing sarcoma dendritic cell vaccination enhances immune responses and induces regression of her pos dcis independent of route results of randomized selection design trial vaccine shows promising results for early stage breast cancer patients eating disorders in adolescents with a history of obesity obese teenagers who lose weight are at risk for developing eating disorders brazilian savanna fruits contain higher bioactive compounds content and higher antioxidant activity relative to the conventional red delicious apple red delicious or wolf apple ? brazilian savanna fruits high in antioxidants voluntary physical activity abolishes the proliferative tumor growth microenvironment created by adipose tissue in animals fed a high fat diet fat cells may play key role in battle against breast cancer a new large species of myloplus characiformes serrasalmidae from the rio madeira basin brazil zorro the new latin american fish species takes off the mask to show its true identity a glycerophospholipid specific pocket in the rvfv class ii fusion protein drives target membrane insertion rift valley fever virus an infection mechanism identified prediction of chemotherapy benefit by endopredict in patients with breast cancer who received adjuvant endocrine therapy plus chemotherapy or endocrine therapy alone test allows doctors to determine most effective treatment for women with breast cancer protecting progress against childhood obesity the national school lunch program rolling back school nutrition standards would threaten progress against childhood obesity soda wars the effect of a soda tax election on university beverage sales berkeley s soda tax election changed drinking habits months before prices went up stretchable surfaces with programmable d texture morphing for synthetic camouflaging skins engineers develop a programmable camouflaging material inspired by octopus skin tcr clonotypes modulate the protective effect of hla class i molecules in hiv infection rare ability to control hiv natural hiv control may rely on sequence of t cell receptor protein fifty sixth supplement to the american ornithologists union check list of north american birds organization of north america s bird species list updated phosphorylase kinase inhibition therapy in burns and scalds topical curcumin gel effective in treating burns and scalds cryptococcus gattii in north american pacific northwest whole population genome analysis provides insights into species evolution and dispersal likely origin of lung fungus invading pacific northwest found by study correction deconstructing a species complex geometric morphometric and molecular analyses define species in the western rattlesnake crotalus viridis biologists identify six new unique species of western rattlesnake endosomolytic polymersomes increase the activity of cyclic dinucleotide sting agonists to enhance cancer immunotherapy new nanoparticle targets tumor infiltrating immune cells flips switch the associations of birth order with personality and intelligence in a representative sample of u.s. high school students massive study birth order has no meaningful effect on personality or iq early life exposome and lung function in children in europe an analysis of data from the longitudinal population based helix cohort exposure to chemicals before and after birth is associated with a decrease in lung function long term coarse pm exposure is associated with asthma among children in medicaid exposure to larger air particles linked to increased risk of asthma in children exploring the effects of maternal eating patterns on maternal feeding and child eating new insight on relationship between parents preschoolers and obesity dietbet a web based program that uses social gaming and financial incentives to promote weight loss social gaming site effective weight loss tool study shows multi modal survey of ad lie penguin mega colonies reveals the danger islands as a seabird hotspot previously unknown supercolony of ad lie penguins discovered in antarctica irrational exuberance and neural crash warning signals during endogenous experimental market bubbles neuroeconomists confirm warren buffett s wisdom brain research suggests an early warning signal tips off smart traders long term movements and activity patterns of an antarctic marine apex predator the leopard seal secret life of an enigmatic antarctic apex predator blood spinal cord barrier disruption contributes to early motor neuron degeneration in als model mice experimental stroke drug also shows promise for people with lou gehrig s disease trends in community violence in england and wales serious violence in england and wales drops in population representative incidence of drug induced acute liver failure based on an analysis of an integrated healthcare system otc medications supplements are most common causes of drug induced liver failure differential aging trajectories of modulation of activation to cognitive challenge in apoe groups reduced modulation predicts poorer cognitive performance alzheimer s gene associated with failure to adapt to cognitive challenge in healthy adults identification of novel human leukocyte antigen a restricted cytotoxic t lymphocyte epitopes on cd for cancer stem cell immunotherapy researchers target cancer stem cells in malignant brain tumors cmv specific t cells generated from naive t cells recognize atypical epitopes and may be protective in vivo new therapy from na ve cells attacks high risk viruses in cord blood transplant patients her expression identifies dynamic functional states within circulating breast cancer cells breast cancer cells found to switch molecular characteristics high performance resorbable composites for load bearing bone fixation devices spider silk key to new bone fixing composite toward the autism motor signature gesture patterns during smart tablet gameplay identify children with autism new ipad game could help diagnose autism in children shelf life neritic habitat use of a turtle population highly threatened by fisheries mediterranean loggerhead turtles dying in waters off the middle east north africa low testosterone concentration and atherosclerotic disease markers in male patients with type diabetes diabetic men with low testosterone run higher risk of developing atherosclerosis endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of jagged blood vessel cells coax colorectal cancer cells into more dangerous state outcomes of adenotonsillectomy in patients with prader willi syndromeadenotonsillectomy in prader willi syndrome adenotonsillectomy may help resolve obstructive sleep apnea in children with prader willi syndrome thermal biases and vulnerability to warming in the world s marine fauna thermal sensitivity of marine communities reveals the most vulnerable to global warming the importance of base flow in sustaining surface water flow in the upper colorado river basin more than half of streamflow in the upper colorado river basin originates as groundwater structure and activity of lipid bilayer within a membrane protein transporter clearest view ever of cell membrane yields unexpected structure research possibilities molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells novel surface marker helps scientists fish out mammary gland stem cells effects of vitamin c supplementation on blood pressure a meta analysis of randomized controlled trials big doses of vitamin c may lower blood pressure formation of metre scale bladed roughness on europa s surface by ablation of ice icy warning for space missions to jupiter s moon baltimore city stores increased the availability of healthy food after wic policy change small urban corner stores offer increased healthy food options the twinkie defense the relationship between carbonated non diet soft drinks and violence perpetration among boston high school students high fizzy soft drink consumption linked to violence among teens mechanism for amplitude alternans in electrocardiograms and the initiation of spatiotemporal chaos new source of dangerous electrical instability in the heart control of wettability using regularly ordered two dimensional polymeric wavy substrates eco friendly waterproof polymer films synthesized using novel method salmonella enterica genomes from victims of a major sixteenth century epidemic in mexico possible cause of early colonial era mexican epidemic identified micronutrients intake is associated with improved sperm dna quality in older men nutrition tied to improved sperm dna quality in older men healthy micronutrient intake linked to reduced dna fragmentation granulocyte colony stimulating factor enhances reward learning through potentiation of mesolimbic dopamine system function immune system emerges as potential partner in opioid cravings fight neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia novel treatment for chronic hypoxic pulmonary hypertension phtn mnsod upregulation sustains the warburg effect via mitochondrial ros and ampk dependent signalling in cancer signal that switches cells to cancerous metabolism uncovered patient and caregiver productivity loss and indirect costs associated with cardiovascular events in europe real cost of heart attacks and strokes double the direct medical expense exposure of fluid milk to led light negatively affects consumer perception and alters underlying sensory properties consumers sour on milk exposed to led light frailty identification and care pathway an interdisciplinary approach to care for older trauma patients new trauma care pathway reduces delirium and likelihood of returning to the hospital optical coherence tomography analysis of the optic nerve head and surrounding structures in long duration international space station astronauts optometrist investigates changes in eye structure in astronauts screening student athletes for sickle cell trait a social and clinical experiment new sickle cell screening program for college athletes comes with serious pitfalls experts say age stress and isolation in older adults living with hiv stress isolation take toll on those under with hiv older people fare better the future of folic acid antagonist therapy in rheumatoid arthritis novel drugs selectively target pathway important in rheumatoid arthritis adaptive randomization of neratinib in early breast cancer two groundbreaking studies reflect new paradigm in breast cancer research chemohormonal therapy in metastatic hormone sensitive prostate cancer two drug combination boosts survival in metastatic prostate cancer serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic alzheimer s disease early prediction of alzheimer s progression blood protein fluorescent label free quantitative detection of nano sized bioparticles using a pillar array scientists develop novel chip for fast and accurate disease detection at low cost using geospatial mapping to design hiv elimination strategies for sub saharan africa un strategy for eliminating hiv in sub saharan africa is unfeasible study finds the association between residency training and internists ability to practice conservatively residency training predicts physicians ability to practice conservatively genome wide dna methylation events in tmprss erg fusion negative prostate cancers implicate an ezh dependent mechanism with mirna a hypermethylation. epigenetic causes of prostate cancer researchers observe modified methylation patterns in a group of prostate cancers dna repair factor brca depletion occurs in alzheimer brains and impairs cognitive function in mice dna repair protein brca implicated in cognitive function and dementia il a is increased in humans with primary hyperparathyroidism and mediates pth induced bone loss in mice immune studies suggest remedies for parathyroid hormone driven bone loss climate change and disasters how framing affects justifications for giving or withholding aid to disaster victims linking climate change to natural disasters influences charitable aid mapping q. gene dosage effects on brain morphometry brain anatomy differs in people with q genetic risk for schizophrenia autism human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow prostate cancer spreads to bones by overtaking the home of blood stem cells pnas plus histone demethylase jmjd c is a coactivator for hypoxia inducible factor that is required for breast cancer progression new molecular culprit linked to breast cancer progression conversion of metaplastic barrett s epithelium into post mitotic goblet cells by gamma secretase inhibition new hope for therapy in heartburn related cancer inflammatory monocytes orchestrate innate antifungal immunity in the lung immune cells need each other to combat deadly lung invading fungus neonatal mortality in east africa and west africa a geographic analysis of district level demographic and health survey data how to attack africa s neonatal mortality problem genome wide association study of breast cancer in latinas identifies novel protective variants on q genetic variant protects some latina women from breast cancer liquid crystal nmr structure of hiv tar rna bound to its selex rna aptamer reveals the origins of the high stability of the complex blocking hiv multiplication structure elucidation of kissing complex what is the magnitude and long term economic cost of care of the british military afghanistan amputee cohort ? high cost of healthcare for uk military amputees from afghan conflict rsk promotes g dna damage checkpoint silencing and participates in melanoma chemoresistance fighting melanoma s resistance to chemotherapy discovery could lead to better treatment of skin cancers vitamin b status in infancy is positively associated with development and cognitive functioning y later in nepalese children children with poor vitamin b status early in life struggle more with tasks recognition and interpreting feelings intestinal dysmotility in a zebrafish danio rerio shank a shank b mutant model of autism see through fish aid scientists in autism related breakthrough green synthesis of low dimensional aluminum oxide hydroxide and oxide using liquid metal reaction media ultrahigh flux membranes liquid metal discovery to make toxic water safe and drinkable direct control of paralysed muscles by cortical neurons movement restored to paralyzed limbs in monkeys through artificial brain muscle connections missing enzymes in the biosynthesis of the anticancer drug vinblastine in madagascar periwinkle madagascar periwinkle research uncovers pathway to cancer fighting drugs comparative effectiveness of high dose versus standard dose influenza vaccines among us medicare beneficiaries in preventing postinfluenza deaths during and in a bad flu season high dose flu vaccine appeared better at preventing deaths in seniors disparities in chronic conditions among women hospitalized for delivery in the united states increasing rates of chronic conditions putting more moms babies at risk three randomized controlled trials of early long chain polyunsaturated fatty acid supplementation on means end problem solving in nine month olds supplementing babies formula with dha boosts cognitive development study finds neonatal phytoestrogen exposure alters oviduct mucosal immune response to pregnancy and affects preimplantation embryo development in the mouse soy based formula ? neonatal plant estrogen exposure leads to adult infertility in female mice the insectivorous bat pipistrellus nathusii uses a mixed fuel strategy to power autumn migration migratory bats use both fat reserves and food to fuel their strenuous long distance flights to the south white matter connectomes at birth accurately predict cognitive abilities at age ai and mris at birth can predict cognitive development at age synergistic interaction ofhoxb andcip apredispose to aggressive prostate cancer new genetic compound marker could help early diagnosis of aggressive prostate cancer effects of antiplatelet therapy after stroke due to intracerebral haemorrhage restart a randomised open label trial aspirin green light for brain bleed stroke patients study suggests caudate nucleus dependent navigational strategies are associated with increased use of addictive drugs direct link established between stimulus response learning substance abuse retinoic acid prevents immunogenicity of milk lipocalin bos d through binding to its immunodominant t cell epitope vitamin a in cattle fodder is potentially protecting against cow s milk allergy secondhand smoke exposure and smoke free policy in philadelphia public housing smoke free policy cuts nicotine detected in philadelphia public housing in half clinicopathological evaluation of chronic traumatic encephalopathy in players of american football high prevalence of evidence of cte in brains of deceased football players deficiency of mitochondrial modulator mcj promotes chemoresistance in breast cancer identification of a chemotherapy resistance factor in breast cancer patients association between fat mass and obesity associated fto gene and hip fracture susceptibility fat and obesity gene also affects hip fracture satellite to ground quantum limited communication using a kg class microsatellite world s first demonstration of space quantum communication using a microsatellite uga is an additional glycine codon in uncultured sr bacteria from the human microbiota human microbe study provides insight into health disease widespread prevalence of cryptic symbiodinium d in the key caribbean reef builder orbicella annularis caribbean coral findings may influence barrier reef studies environmental symbiont acquisition may not be the solution to warming seas for reef building corals climate change remains a real threat to corals pandemrix vaccination is not associated with increased risk of islet autoimmunity or type diabetes in the teddy study children the risk of type diabetes not increased by swine flu vaccine pandemrix the effects of growth hormone on body composition and physical performance in recreational athletes a randomized trial human growth hormone significantly increases sprint capacity in healthy recreational athletes mrna based dendritic cell vaccination induces potent antiviral t cell responses in hiv infected patients new hiv vaccine tested on people shows limited success first clinical evidence that imaging with somatostatin receptor antagonists is feasible first proof in patients of an improved magic bullet for cancer detection and radio therapy fish and robots swimming together in a water tunnel robot color and tail beat frequency influence fish behavior underwater robots influence complex swimming behaviors of schooling fish detection of the gravitational redshift in the orbit of the star s near the galactic centre massive black hole einstein s general relativity confirmed near black hole higher prevalence of low t syndrome in patients with chronic fatigue syndrome a case control study chronic fatigue syndrome possibly explained by lower levels of key thyroid hormones ruthenium containing linear helicates and mesocates with tuneable p selective cytotoxicity in colorectal cancer cells compound discovered that targets cancer cells lacking the protective p guardian gene european cardiac nurses current practice and knowledge on anticoagulation therapy poor patient warfarin knowledge may increase risk of deadly side effects hematodinium sp. and its bacteria like endosymbiont in european brown shrimp crangon crangon lifestyle of a killer in wild european brown shrimp parasitic dinoflagellates have bacteria like endosymbionts the optimal age for screening adolescents and young adults without identified risk factors for hiv new evidence supports hiv screening in young adulthood enhancement of cutaneous immunity during aging by blocking p mitogen activated protein map kinase induced inflammation improving vaccines for the elderly by blocking inflammation metabolic remodeling of the human red blood cell membrane chemical energy influences tiny vibrations of red blood cell membranes initial cholecystectomy vs sequential common duct endoscopic assessment and subsequent cholecystectomy for suspected gallstone migration removing gall bladder for suspected common duct stone shows benefit a nasally applied cellulose powder in seasonal allergic rhinitis sar in children and adolescents reduction of symptoms and relation to pollen load children s hay fever relieved by cellulose powder without adverse effects study suggests treatment of sleep disorders after traumatic brain injury treating sleep disorders in people with traumatic brain injury may not eliminate symptoms the evolution of rotation group bias will the real unemployment rate please stand up ? will the real unemployment rate please stand up ? population variation revealed high altitude adaptation of tibetan mastiffs tibetan mastiffs equally adapted to high altitudes of tibet rescue of long range circuit dysfunction in alzheimer s disease models alzheimer s disease plaques impair memory formation during sleep genetic effects on sleep wake variation of seizures genes influence sleep wake timing of seizures in people with epilepsy prevalence of sexual dysfunction and impact of contraception in female german medical students hormonal contraceptives associated with higher risk of female sexual dysfunction study finds comparative effectiveness of a multifaceted intervention to improve adherence to annual colorectal cancer screening in community health centers outreach doubles colon cancer screening in low income communities early childhood curiosity and kindergarten reading and math academic achievement study explores link between curiosity and school achievement the global response to hiv in men who have sex with men despite advances hiv epidemic continues among gay men across the globe arbuscule containing and non colonized cortical cells of mycorrhizal roots undergo a massive and specific reprogramming during arbuscular mycorrhizal development good preparation is key even for plant cells and symbiotic fungi how physicians professional socialisation and social technologies may affect colleagues in substance use disorders medical doctors remain trapped in their substance use disorders study finds impact of i spect spiral ct on nodal staging of differentiated thyroid carcinoma at first radioablation molecular imaging enables earlier individualized treatment of thyroid cancer immunotherapy with pi k inhibitor and toll like receptor agonist induces ifn il polyfunctional t cells that mediate rejection of murine tumors discovery of new vaccine approach for treatment of cancer visitor perceptions of captive endangered barbary macaques macaca sylvanus used as photo props in jemaa el fna square marrakech morocco using endangered barbary macaques as photo props could negatively impact moroccan tourism soundscapes in the past investigating sound at the landscape level archaeologists put sound back into a previously silent past fear of violent consequences and condom use among women attending an std clinic study links intimate partner violence risk of hiv targeted cognitive training improves auditory and verbal outcomes among treatment refractory schizophrenia patients mandated to residential care targeted cognitive training benefits patients with severe schizophrenia year trends in an index of survival for all cancers combined and survival adjusted for age and sex for each cancer in england and wales a population based study substantial improvement in england wales cancer survival over years overshadowed by low survival for brain stomach lung oesophageal and pancreatic cancers ethnicity and child health in northern tanzania maasai pastoralists are disadvantaged compared to neighbouring ethnic groups maasai of tanzania facing severe food insecurity chronic child malnourishment the remarkable convergence of skull shape in crocodilians and toothed whales crocodiles and dolphins evolved similar skulls to catch the same prey diffusion tensor imaging implicates prefrontal axonal injury in executive dysfunction following mild traumatic brain injury strong link found between concussions and brain tissue injury skn and nrf couples proline catabolism with lipid metabolism during nutrient deprivation high sugar diet no problem for genetic mutants the comparative oncology trials consortium using spontaneously occurring cancers in dogs to inform the cancer drug development pathway studying cancer in pet dogs to find new treatments for human patients the effect of observation on cranial computed tomography utilization for children after blunt head trauma ct scans are frequently unnecessary after head injury in children large study finds health care workers part of the system or part of the public ? ambivalent risk perception in health care workers when a health risk is close to home health care professionals base their positions on vaccines on their own emotions personal experiences impact of the aya hope comorbidity index on assessing health care service needs and health status among adolescents and young adults with cancer first tool to assess impact of co illnesses in young cancer patients reinforcement learning agents providing advice in complex video games knowledge transfer between computers computers teach each other pac man epstein barr virus an important vaccine target for cancer prevention scientists outline steps toward epstein barr virus vaccine thirty day postoperative mortality among individuals with hiv infection receiving antiretroviral therapy and procedure matched uninfected comparators postoperative mortality rates low among patients with hiv prescribed art using herbarium derived dnas to assemble a large scale dna barcode library for the vascular plants of canada building a dna barcode library for the canadian flora using herbarium collections greenlandic inuit show genetic signatures of diet and climate adaptation arctic inuit native american cold adaptations may originate from extinct hominids intentional weight loss for overweight and obese knee osteoarthritis patients is more better ? when it comes to weight loss in overweight and obese adults with knee osteoarthritis more is better phosphorylation of a wrky transcription factor by two pathogen responsive mapks drives phytoalexin biosynthesis in arabidopsis missing link in plant defense against fungal disease found verapamil and beta cell function in adults with recent onset type diabetes human clinical trial reveals verapamil as an effective type diabetes therapy living beyond the limits of survival wood ants trapped in a gigantic pitfall trapped in a nuclear weapon bunker wood ants survive for years in poland one year outcome for responders of cognitive behavioral therapy for pediatric obsessive compulsive disorder cognitive behavioral therapy for children and adolescents with ocd works in the long run impact of a group mind body intervention on pregnancy rates in ivf patients mind body program increases pregnancy rates in ivf treatment study finds altered ph and reduced calcium levels drive near extirpation of native crayfish cambarus bartonii in algonquin park ontario canada crayfish decline in algonquin park lakes linked to lack of calcium evidence that children born at early term weeks are at increased risk for diabetes and obesity related disorders early term babies are at greater risk for diabetes and obesity related diseases use of antiepileptic drugs and dementia risk an analysis of finnish health register and german health insurance data antiepileptic drugs increase risk of alzheimer s and dementia quantifying dispersal from hydrothermal vent fields in the western pacific ocean hot larvae calculating dispersal from unique submarine hot spring ecosystems dark matter decay between phase transitions at the weak scale new theory on the origin of dark matter who has sex with whom ? characteristics of heterosexual partnerships reported in a national probability survey and implications for sti risk who has sex with whom ? study of heterosexual partnerships reveals worryingly low condom use strengthening medical product regulation in low and middle income countries product regulatory systems in low and middle income countries must be strengthened experts argue neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia spinal cord stimulation physical therapy help paralyzed man stand walk with assistance therapy with the opioid antagonist naltrexone promotes mucosal healing in active crohn s disease a randomized placebo controlled trial use of naltrexone reduces inflammation in crohn s patients study suggests lipid metabolism genes in contralateral unaffected breast and estrogen receptor status of breast cancer gene profile may help identify risk for hormone sensitive hormone insensitive breast cancer alarmist by bad design strongly popularized unsubstantiated claims undermine credibility of conservation science insectageddon is alarmist by bad design scientists point out the study s major flaws a bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids lab grown mini lungs successfully transplanted into mice different faces of discrimination perceived discrimination among homeless adults with mental illness in healthcare settings discrimination among homeless adults in toronto with mental illness mapping a keystone shrub species huckleberry vaccinium membranaceum using seasonal colour change in the rocky mountains new tool maps a key food source for grizzly bears huckleberries persistent hiv replication maintains the tissue reservoir during therapy ongoing hiv replication replenishes viral reservoirs during therapy road map to clean energy using laser beam ignition of boron hydrogen fusion laser boron fusion now leading contender for energy from dna repair to proteome protection new molecular insights for preventing non melanoma skin cancers and skin aging indications for prevention of sun damage associated with skin aging non melanoma skin cancer found annual vaccination against influenza virus hampers development of virus specific cd t cell immunity in children annual childhood flu vaccines may interfere with development of crossresistance binge drinking and eating problems in russian adolescents binge drinking is strongly associated with eating problems among russian girls an amphibious whale from the middle eocene of peru reveals early south pacific dispersal of quadrupedal cetaceans ancient four legged whale with otter like features found along the coast of peru neural function before and after mindfulness based cognitive therapy in anxious adolescents at risk for developing bipolar disorder changes in brain activity after mindfulness based cognitive therapy in adolescents identification of food grade subtilisins as gluten degrading enzymes to treat celiac disease common bacteria show promise for treating celiac disease the duck genome and transcriptome provide insight into an avian influenza virus reservoir species duck genome provides new insight into fighting bird flu bisphenol a exposure and symptoms of anxiety and depression among inner city children at years of age prenatal bpa exposure linked to anxiety and depression in boys first insights into the vocal repertoire of infant and juvenile southern white rhinoceros young southern white rhinos may produce four distinct context dependent calls high precision relocation and event discrimination for the september underground nuclear explosion and subsequent seismic events at the north korean test site regional seismic data help locate september north korean nuclear test malnutrition inflammation modifies the relationship of cholesterol with cardiovascular disease physicians beware cholesterol counts in kidney disease patients effects of pelleting extrusion or extrusion and pelleting on energy and nutrient digestibility in diets containing different levels of fiber and fed to growing pigs pelleting extrusion increase digestible metabolizable energy in diets for pigs a new species of barbet capitonidae capito from the cerros del sira ucayali peru new bird species discovered in cloud forest of peru in situ tumor pd l mrna expression is associated with increased tils and better outcome in breast carcinomas targets for immunotherapy in early stage breast cancer endothelial srf mrtf ablation causes vascular disease phenotypes in murine retinae gene switch steers blood supply to the retina maternal infant and childhood risks associated with advanced paternal age the need for comprehensive counseling for men older fathers put health of partners unborn children at risk reducing eif e eif g interactions restores the balance between protein synthesis and actin dynamics in fragile x syndrome model mice neuroscientists find promise in intervention to normalize biological functions in fragile x mice evidence for non steady state carbon emissions from snow scoured alpine tundra alpine tundra releases long frozen co to the atmosphere exacerbating climate warming forests synchronize their growth in contrasting eurasian regions in response to climate warming forests synchronize their growth in response to climate change a rare penetrant mutation in cfh confers high risk of age related macular degeneration researchers identify a genetic mutation associated with high risk of age related macular degeneration parental concerns provider response and timeliness of autism spectrum disorder diagnosis father and mother knows best healthcare providers responses to parental concerns can delay diagnosis of autism spectrum disorders feasibility of quarantine procedures for bison bison bison calves from yellowstone national park for conservation of brucellosis free bison bison ready for new pastures ? protocol used to demonstrate brucellosis free bison from infected herds neural bases of ingroup altruistic motivation in soccer fans neuroimaging of soccer fans brain reveals neural basis of ingroup altruistic motivation longitudinal effects of mild traumatic brain injury and posttraumatic stress disorder comorbidity on postdeployment outcomes in national guard soldiers deployed to iraq us soldiers with post traumatic stress disorder more likely to feel long term psychological effect bidirectional brain gut interactions and chronic pathological changes after traumatic brain injury in mice traumatic brain injury causes intestinal damage study shows prognostic significance of non hpv genotypes in oropharyngeal squamous cell carcinoma particular hpv strain linked to improved prognosis for throat cancer host pathogen coevolution increases genetic variation in susceptibility to infection evolving alongside viruses impacts susceptibility to future infections plants respond to leaf vibrations caused by insect herbivore chewing plants respond to leaf vibrations caused by insects chewing long term outcomes of stereotactic body radiotherapy for low risk and intermediate risk prostate cancer shorter course of radiation therapy effective in treating men with prostate cancer study differential effects of late gestation maternal overnutrition on the regulation of surfactant maturation in fetal and postnatal life babies of overweight obese or diabetic mothers have an increased risk of lung problems integration of genotypic and phenotypic screening reveals molecular mediators of melanoma stromal interaction possible biomarker and therapeutic target for melanoma discovered manganese binding to rubisco could drive a photorespiratory pathway that increases the energy efficiency of photosynthesis shedding light on the energy efficiency of photosynthesis chronic psychological stress and racial disparities in body mass index change between black and white girls aged weight gain worry for stressed black girls stress and weight more strongly linked in black girls than white counterparts a multi center study on human brain glutathione conformation using magnetic resonance spectroscopy a new study indicates the possibility to monitor the progression of alzheimer s disease by monitoring major brain antioxidant levels using noninvasive techniques the complex effects of the slow releasing hydrogen sulfide donor gyy in a model of acute joint inflammation and in human cartilage cells foul smelling gas shows health benefits in reducing joint swelling the role of physicians in asylum evaluation documenting torture and trauma professor urges physicians to help victims of torture seeking asylum proteomic analysis of neurons microdissected from formalin fixed paraffin embedded alzheimer s disease brain tissue new technique permits cell specific examination of proteins in alzheimer s brain tissue eyes wide shut the impact of dim light vision on neural investment in marine teleosts bigger eyes but reduced brain power in nocturnal fishes heat shock protein peptide complex vaccination for recurrent glioblastoma a phase ii single arm trial personalized vaccine for most lethal type of brain tumor shows promise synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of r mice zinc fingers a new tool in the fight against huntington s disease hysterectomy corrected uterine corpus cancer incidence trends and differences in relative survival reveal racial disparities and rising rates of nonendometrioid cancers incidence rates of aggressive subtypes of uterine cancer rising study shows a g like state allows hiv to bypass samhd restriction in macrophages study shows how hiv breaches macrophage defenses could be step towards cure factors associated with physician follow up among patients with chest pain discharged from the emergency department one in four patients who visited emergency department for chest pain did not receive follow up care pollen exposure in pregnancy and infancy and risk of asthma hospitalisation a register based cohort study pollen exposure during pregnancy affects child s risk of early asthma study finds female hormonal factors and the risk of endometrial cancer in lynch syndrome association between genetic condition hormonal factors and risk of endometrial cancer rapid mortality falls after risk factor changes in populations decrease in smoking reduces death rates within months randomized controlled trial of brief mindfulness training and hypnotic suggestion for acute pain relief in the hospital setting mind body therapies immediately reduce unmanageable pain in hospital patients vascular cognitive impairment neuropathology guidelines vcing the contribution of cerebrovascular pathology to cognitive impairment post mortem assessment guidelines for vascular cognitive impairment does hormone replacement therapy hrt cause breast cancer ? an application of causal principles to three studies part. trends in breast cancer incidence in relation to the use of hrt no clear evidence that decline in hormone replacement therapy use linked to fall in breast cancer a new large bodied omnivorous bat noctilionoidea mystacinidae reveals lost morphological and ecological diversity since the miocene in new zealand giant extinct burrowing bat discovered in new zealand constraining the orbit of the supermassive black hole binary astronomers detect orbital motion in pair of supermassive black holes crimean congo haemorrhagic fever virus infection is lethal for adult type i interferon receptor knock out mice new breakthrough in fight against lethal cchf virus association between hospital volume processes of care and outcomes in patients admitted with heart failure insights from get with the guidelines heart failure following treatment guidelines more important than volume for assessing heart failure care isotopic insight on paleodiet of extinct pleistocene megafaunal xenarthrans from argentina giant sloth was vegetarian diet of fossil megatherium decoded deep venous thrombosis after general surgical operations at a university hospital two year data from the acs nsqip with certain preventive measures incidence of deep vein thrombosis after general surgery appears low possibly catheter related single unit responses selective for whole faces in the human amygdala neuroscientists record novel responses to faces from single neurons in humans financial incentives for linkage to care and viral suppression among hiv positive patients financial incentives enhance viral suppression among hiv positive persons in the us living under threat mutual threat perception drives anti muslim and anti western hostility in the age of terrorism same psychological mechanism explains violence among muslim and western extremists guiding healthier food choice systematic comparison of four front of pack labelling systems and their effect on judgements of product healthiness labels on front of food packaging can enable healthier choices new research finds a randomized prospective study of lumpectomy margin assessment with use of marginprobe in patients with nonpalpable breast malignancies new technology to detect lingering cancer cells during breast surgery reduced orienting to audiovisual synchrony in infancy predicts autism diagnosis at years of age reduced attention to audiovisual synchrony in infancy predicts autism diagnosis robust global ocean cooling trend for the pre industrial common era years of global ocean cooling halted by global warming structural plasticity of the ventral stream and aphasia recovery aphasia recovery via speech therapy related to structural plasticity of the ventral stream close your eyes or open your mind effects of sleep and mindfulness exercises on entrepreneurs exhaustion mindfulness and sleep can reduce exhaustion in entrepreneurs effectiveness of different approaches to arsenic mitigation over years in araihazar bangladesh implications for national policy study identifies better cheaper ways to stem arsenic poisoning in bangladesh valnoctamide inhibits cytomegalovirus infection in developing brain and attenuates neurobehavioral dysfunctions and brain abnormalities psychiatric medication protects developing mouse brain from birth defects an unusual presentation of chronic cyanide toxicity from self prescribed apricot kernel extract man develops cyanide poisoning from apricot kernel extract a major lineage of non tailed dsdna viruses as unrecognized killers of marine bacteria new type of virus found in the ocean health problems precede traumatic brain injury in older adults health problems may predict traumatic brain injuries in older adults human induced greening of the northern extratropical land surface climate study finds human fingerprint in northern hemisphere greening identification biology impacts and management of stink bugs hemiptera heteroptera pentatomidae of soybean and corn in the midwestern united states stink bugs free guide for agricultural integrated pest management trends in high dose opioid prescribing in canada high dose opioid prescribing continues to climb in canada temporal development of the gut microbiome in early childhood from the teddy study importance of infant diet in establishing a healthy gut protected areas act as establishment centres for species colonizing the uk protected wildlife areas are welcome mats for uk s bird newcomers zinc acetate lozenges for treating the common cold an individual patient data meta analysis zinc lozenges help most patients recover earlier from the common cold reconciling evidence from ancient and contemporary genomes a major source for the european neolithic within mediterranean europe new dna research shows true migration route of early farming in europe years ago clinical outcomes of melanoma brain metastases treated with stereotactic radiosurgery and anti pd therapy anti ctla therapy braf mek inhibitors braf inhibitor or conventional chemotherapy immune and targeted therapies with radiation therapy improves outcomes for melanoma brain metastases patients say researchers an early american smallpox vaccine based on horsepox new clues on the historical origin of the vaccine used to eradicate smallpox detection of the far infrared o iii and dust emission in a galaxy at redshift. early metal enrichment in the heart of the reionization era the rise and fall of ziggy star formation and the rich dust from ancient stars gender stereotypes about intellectual ability emerge early and influence children s interests stereotypes about brilliance affect girls interests as early as age new study finds the motivation for exercise over palatable food is dictated by cannabinoid type receptors go for a run or eat chocolate a choice dictated by the cannabinoid receptors randomized trial of peanut consumption in infants at risk for peanut allergy peanut consumption in infancy prevents peanut allergy study finds attitudes of primary care practitioners in managing chronic pain patients prescribed opioids for pain a prospective longitudinal controlled trial monitoring support help patients primary care physicians dealing with chronic pain multi jet propulsion organized by clonal development in a colonial siphonophore marine animal colony is a multi jet swimming machine scientists report antigen specific immunoglobulin variable region sequencing measures humoral immune response to vaccination in the equine neonate optimizing horse vaccination schedules early age immune response in foals correlating electronic transport and f noise in mose field effect transistors study on low noise high performance transistors may bring innovations in electronics practice level variation in statin use among patients with diabetes insights from the pinnacle registry low statin use in people with diabetes despite cardioprotective effects guidelines uncoupling protein and expression pattern during stem cell differentiation provides new insight into their putative function hot on the trail of cellular metabolism early detection of disease effect of dietary estrogens from bovine milk on blood hormone levels and reproductive organs in mice consumption of natural estrogens in cow s milk does not affect blood levels or reproductive health the influence of positive mood on different aspects of cognitive control being in a good mood may lead to poor memory student drug testing and positive school climates testing the relation between two school characteristics and drug use behavior in a longitudinal study school drug tests don t work but positive climate might effect of gravity and microgravity on intracranial pressure likely cause and potential prevention of vision deterioration in space light enabled reversible self assembly and tunable optical properties of stable hairy nanoparticles self assembled hairy nanoparticles could give a double punch to cancer robot driven downward pelvic pull to improve crouch gait in children with cerebral palsy robot driven device improves crouch gait in children with cerebral palsy the stability of educational achievement across school years is largely explained by genetic factors genes are key to academic success study suggests bioreducible polymeric nanoparticles containing multiplexed cancer stem cell regulating mirnas inhibit glioblastoma growth and prolong survival scientists create nano size packets of genetic code aimed at brain cancer seed cells results at months from the prospective randomized multi center investigational device exemption trial of prodisc c versus anterior cervical discectomy and fusion with year follow up and continued access patients for back neck pain artificial disc replacement has cost outcome advantages over fusion surgery ian fleming and the public profile of the cia a close bond how the cia exploited for gadget ideas and public relations reciprocal modulation between amyloid precursor protein and synaptic membrane cholesterol revealed by live cell imaging scientists propose new theory on alzheimer s amyloid connection did the drinking age promote high school dropout ? implications for current policy legal drinking age of tied to high school dropout rate association of dietary circulating and supplement fatty acids with coronary risk new evidence raises questions about the link between fatty acids and heart disease candidatus neoehrlichia sp. in an austrian fox is distinct from candidatus neoehrlichia mikurensis but closer related to candidatus neoehrlichia lotoris new presumably tick borne bacterium discovered in an austrian fox location specific responses to thermal stress in larvae of the reef building coral montastraea faveolata discovery of how coral reefs adapt to global warming could aid reef restoration extinction risk from climate change is reduced by microclimatic buffering microclimates may provide wildlife with respite from warming temperatures parallel selective pressures drive convergent diversification of phenotypes in pythons and boas pythons and boas shed new light on reptile evolution real time intraoperative monitoring of blood coagulability via coherence gated light scattering light beam replaces blood test during heart surgery reverse thermal gel for in utero coverage of spina bifida defects an innovative bioengineering alternative to open fetal repair bioengineering as viable alternative to open fetal repair for spina bifida research proves potent inhibition of the classical pathway of complement by a novel c q binding peptide derived from the human astrovirus coat protein researchers closer to development of drug to prevent deadly immune response immunotherapy with the pres based grass pollen allergy vaccine bm induces antibody responses protecting against hepatitis b infection grass pollen allergy vaccine also effective against hepatitis b chemogenomics approaches to rationalizing the mode of action of traditional chinese and ayurvedic medicines paving the way for greater use of ancient medical knowledge caffeine use disorder a comprehensive review and research agenda caffeine use disorder widespread health problem that needs more attention dietary fat induced taurocholic acid promotes pathobiont expansion and colitis in il mice western diet changes gut bacteria and triggers colitis in those at risk long term ocean oxygen depletion in response to carbon dioxide emissions from fossil fuels dramatic expansion of dead zones in oceans likely with unchecked global warming paramagnetic cellulose dna isolation improves dna yield and quality among diverse plant taxa plant dna isolation twice the dna yield in less time structure function and control of the human musculoskeletal network network model of the musculoskeletal system predicts compensatory injuries middle holocene plant cultivation on the atlantic forest coast of brazil ? coastal strip in brazil sheds new light on early farming interconversion between intestinal stem cell populations in distinct niches tales from the crypt study on gut cell regeneration reconciles long standing research controversy regulatory t cells promote myelin regeneration in the central nervous system researchers make major brain repair discovery in fight against multiple sclerosis neuronal synchrony reveals working memory networks and predicts individual memory capacity human working memory is based on dynamic interaction networks in the brain wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy implantable biodegradable devices speed nerve regeneration in rats persistence of bactericidal antibodies following early infant vaccination with a serogroup b meningococcal vaccine and immunogenicity of a preschool booster dose booster dose of new meningitis vaccine may be beneficial autism gene variant causes hyperserotonemia serotonin receptor hypersensitivity social impairment and repetitive behavior novel mouse model for autism yields clues to a year old mystery waning protection after fifth dose of acellular pertussis vaccine in children protection against whooping cough waned during the five years after fifth dose of dtap blockade of interferon beta but not interferon alpha signaling controls persistent viral infection scientists identify interferon beta as likely culprit in persistent viral infections the effect of acceptance of illness on the quality of life in patients with chronic heart failure poor acceptance of illness associated with worse quality of life in chronic heart failure health behaviors in family members of patients completing cancer treatment cancer experience presents time for lifestyle changes in both survivors and family members targeting the s p s pr axis mitigates cancer induced bone pain and neuroinflammation cause and possible relief of cancer bone pain long term sea level rise implied by. c and c warming levels significant sea level rise in a two degree warmer world replacing saturated fat with walnuts or vegetable oils improves central blood pressure and serum lipids in adults at risk for cardiovascular disease a randomized controlled feeding trial walnuts may help lower blood pressure for those at risk of heart disease opportunities and challenges for hiv care in overlapping hiv and tb epidemics tuberculosis presents major challenges to hiv treatment in developing countries salt reduction in england from to its relationship to blood pressure stroke and ischaemic heart disease mortality lower salt intake likely to have had key role in plummeting cardiovascular disease deaths in past decade impact of the mycobaterium africanum west africa lineage on tb diagnostics in west africa decreased sensitivity of rapid identification tests in the gambia rapid tb test accuracy in west africa compromised by mycobacterium diversity traumatic brain injury in adult rats causes progressive nigrostriatal dopaminergic cell loss and enhanced vulnerability to the pesticide paraquat. traumatic brain injury increases risk of parkinson s disease researchers say threat doubles with exposure to the pesticide paraquat genomic signatures for paclitaxel and gemcitabine resistance in breast cancer derived by machine learning artificial intelligence used to improve breast cancer patient outcomes anaerobic oxidization of methane in a minerotrophic peatland enrichment of nitrite dependent methane oxidizing bacteria new peatland bacteria feed on greenhouse gas and excess fertilizer medical therapy for heart failure with reduced ejection fraction drugs for heart failure are still under prescribed years after initial study a snapshot of a coral holobiont a transcriptome assembly of the scleractinian coral porites captures a wide variety of genes from both the host and symbiotic zooxanthellae world s first simultaneous genetic sequencing of host coral symbiont algae protein composition of infectious spores reveals novel sexual development and germination factors in cryptococcus meningitis research advances on scourge of transplant wards adolescents from upper middle class communities substance misuse and addiction across early adulthood kids in high achieving schools addiction down the road ? future cardiovascular disease in china markov model and risk factor scenario projections from the coronary heart disease policy model u china by cardiovascular disease and death rates will surge in china researchers predict earth and moon impact flux increased at the end of the paleozoic scientists find increase in asteroid impacts on ancient earth by studying the moon seven core principles of substance use treatment system design to aid in identifying strengths gaps and required enhancements seven core principles can help substance use treatment systems focus on high level goals abrupt rise of new machine ecology beyond human response time robots take over economy sudden rise of global ecology of interacting robots trade at speeds too fast for humans molecular evidence for historic long distance translocations of brown bears in the balkan region ceausescu s flying bears molecular genetics provides evidence for an unusual dispersal mode in european brown bears four forensic entomology case studies records and behavioral observations on seldom reported cadaver fauna with notes on relevant previous occurrences and ecology new forensic entomology observations expand knowledge of decomposition ecology forgotten mediterranean calving grounds of grey and north atlantic right whales evidence from roman archaeological records ancient bones reveal whale species lost from the mediterranean sea long term use of ticagrelor in patients with prior myocardial infarction long term ticagrelor cuts risk of future events after heart attack viraemia suppressed in hiv infected humans by broadly neutralizing antibody bnc in first human study new antibody therapy shows promise in suppressing hiv infection ability to cope with pain puts migraine surgery patients in perspective migraine surgery produces dramatic improvements in functioning study finds the f box protein kib mediates brassinosteroid induced inactivation and degradation of gsk like kinases in arabidopsis new step in plant mastermind hormone s pathway revealed cellular ddx rna helicase inhibits influenza a virus replication but is counteracted by the viral ns protein possible new target to attack flu virus identified lethal interactions between parasites and prey increase niche diversity in a tropical community more to biological diversity than meets the eye specialization by insect species is the key hepatic decompensation in antiretroviral treated patients co infected with hiv and hepatitis c virus compared with hepatitis c virus monoinfected patients hepatitis c remains major problem for hiv patients despite antiretroviral therapy annual trends in follow up visits for pediatric concussion in emergency departments and physicians offices two thirds of children with concussions not receiving medical follow ups comparative effectiveness and safety of cognitive enhancers for treating alzheimer s disease systematic review and network metaanalysis safety effectiveness of cognitive enhancers for alzheimer s ranked morphological and functional diversity in therizinosaur claws and the implications for theropod claw evolution all teeth and claws ? new study sheds light on dinosaur claw function short term diesel exhaust inhalation in a controlled human crossover study is associated with changes in dna methylation of circulating mononuclear cells in asthmatics breathing in diesel exhaust leads to changes deep under the hood testing hypotheses of developmental constraints on mammalian brain partition evolution using marsupials australian study uses new technique to challenge brain development hypothesis early administration of azithromycin and prevention of severe lower respiratory tract illnesses in preschool children with a history of such illnesses for kids prone to wheezing with respiratory infections early antibiotics help ? bcat controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases targeting broken metabolism in immune cells reduces inflammatory disease the effectiveness of yoga in modifying risk factors for cardiovascular disease and metabolic syndrome a systematic review and meta analysis of randomized controlled trials yoga as a potential therapy for cardiovascular disease metabolic syndrome racial differences in human platelet par reactivity reflect expression of pctp and mir c racial difference in blood clotting warrants closer look at heart attack medications combined analysis of human and experimental murine samples identified novel circulating micrornas as biomarkers for atrial fibrillation potential rna markers of abnormal heart rhythms identified in circulating blood more than percent decline over years in total flying insect biomass in protected areas three quarters of the total insect population lost in protected nature reserves consumption of fructose and high fructose corn syrup increase postprandial triglycerides ldl cholesterol and apolipoprotein b in young men and women fructose consumption increases risk factors for heart disease study suggests us dietary guideline for upper limit of sugar consumption is too high aberrant chromatin at genes encoding stem cell regulators in human mixed lineage leukemia tracking the molecular pathway to mixed lineage leukemia distinct circuits for recovery of eye dominance and acuity in murine amblyopia normal eye dominance is not necessary for restoring visual acuity in amblyopia in silico identified targeted inhibitors of p glycoprotein overcome multidrug resistance in human cancer cells in culture new drug like compounds may improve odds of men battling prostate cancer researchers find effect of group vs individual cognitive processing therapy in active duty military seeking treatment for posttraumatic stress disorder a randomized clinical trial active duty military find ptsd relief through individual cognitive therapy state medicaid expansion decisions and disparities in women s cancer screening inconsistent medicaid expansion would widen disparities in screenings for women s cancers regional alcohol consumption and alcohol related mortality in great britain novel insights using retail sales data alcohol sales linked with alcohol deaths across great britain regions greater exposure to sexual content in popular movies predicts earlier sexual debut and increased sexual risk taking exposure to sexual content in popular movies predicts sexual behavior in adolescence low cigarette consumption and risk of coronary heart disease and stroke meta analysis of cohort studies in study reports just one cigarette a day carries greater risk of heart disease and stroke than expected warn expert inferring multi scale neural mechanisms with brain network modelling the virtual brain patient data allow researchers to study brain function using detailed induction of pluripotent stem cells from human third molar mesenchymal stromal cells a smart use for wisdom teeth making stem cells efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation a secondary analysis of a randomised controlled trial apixaban superior to warfarin across range of patient risk scores study finds characterization of a novel murine model to study zika virus new mouse model for zika virus to enable immediate screening of potential drugs and vaccines editable supercapacitors with customizable stretchability based on mechanically strengthened ultralong mno nanowire composite customizable fabric like power source for wearable electronics exposure to parental smoking in childhood or adolescence is associated with increased carotid intima media thickness in young adults evidence from the cardiovascular risk in young finns study and the childhood determinants of adult health study passive smoking causes irreversible damage to children s arteries working toward gender diversity and inclusion in medicine myths and solutions five solutions offered for achieving gender equality in medicine and science evidence of an early projectile point technology in north america at the gault site texas usa gault site research pushes back date of earliest north americans integrative single cell analysis of transcriptional and epigenetic states in the human adult brain updated brain cell map connects various brain diseases to specific cell types patient satisfaction with postmastectomy breast reconstruction a comparison of saline and silicone implants breast cancer patients prefer silicone over saline implants after mastectomy whales use distinct strategies to counteract solar ultraviolet radiation whales get a tan too pigment in whale skin increases in response to sunshine snow leopard and himalayan wolf food habits and prey selection in the central himalayas nepal snow leopard and himalayan wolf diets are about one quarter livestock midlife self reported social support as a buffer against premature mortality risks associated with childhood abuse strong relationships in midlife may offset health risks for victims of childhood abuse sofosbuvir and ribavirin for hepatitis c in patients with hiv coinfection combination treatment for hep c associated with favorable response among hiv patients porphyromonas gingivalis may interfere with conception in women common periodontal pathogen may interfere with conception in women cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns research reveals insulin producing beta cells may change function in diabetes health and behavioral survey of over finnish cats unique health survey of finnish cats reveals common and breed specific illnesses quantifying greenhouse gas emission of asphalt pavement preservation at construction and use stages using life cycle assessment keeping roads in good shape reduces greenhouse gas emissions exome sequencing identifies biallelic msh germline mutations as recessive subtype of colorectal adenomatous polyposis discovery of a novel gene for hereditary colon cancer oral contraceptive use as a risk factor for premenopausal breast cancer a meta analysis oral contraceptives increase risk for breast cancer in some women meta analysis finds generation of gene modified cynomolgus monkey via cas rna mediated gene targeting in one cell embryos precise gene editing in monkeys paves the way for valuable human disease models progression of breast cancer cells was enhanced by endocrine disrupting chemicals triclosan and octylphenol via an estrogen receptor dependent signaling pathway in cellular and mouse xenograft models in lab tests the antimicrobial ingredient triclosan spurs growth of breast cancer cells a longitudinal study on stability and transitions among bullying roles bullying evolves with age and proves difficult to escape from stable creeping fault segments can become destructive as a result of dynamic weakening faulty behavior new earthquake fault models show that stable zones may contribute to the generation of massive earthquakes braf targeting sensitizes resistant melanoma to cytotoxic t cells combo t cell and targeted therapy strategy for resistant melanoma with braf mutation traumatic brain injuries in mixed martial arts a systematic review rate and risk of head injury in mixed martial arts remain unknown control of pyrethroid resistant chagas disease vectors with entomopathogenic fungi fungi pathogenic to insects are new tool in fight against chagas disease breastfeeding continuation at weeks postpartum remediates the negative effects of prenatal intimate partner violence on infant temperament breastfeeding can erase effects of prenatal violence for newborns synchronization of north pacific and greenland climates preceded abrupt deglacial warming synchronization of north atlantic north pacific preceded abrupt warming end of ice age genome wide evidence reveals that african and eurasian golden jackals are distinct species golden jackals of east africa are actually golden wolves recipients of vaccine against the swine flu have enhanced neutralization responses to the novel h n influenza virus swine flu shot linked to stronger immune response to st century pandemic flu allergen specific cytokine polarization protects shetland ponies against culicoides obsoletus induced insect bite hypersensitivity shetland pony midge study offers clues to curbing allergies ripplocations a universal deformation mechanism in layered solids from playing cards to tectonic plates layered materials pushed to the brink trends in the black white life expectancy gap among us states life expectancy gap between blacks and whites in u.s. varies considerably across states cataloging the bloomberg era new york city legislation relevant to cardiovascular risk factors bloomberg era s emphasis on health in all policies improved new yorkers heart health effect of macitentan on the development of new ischemic digital ulcers in patients with systemic sclerosis dual and dual randomized clinical trials drug does not reduce digital ulcers in patients with systemic sclerosis high throughput comparison functional annotation and metabolic modeling of plant genomes using the plantseed resource perennial corn crops ? it could happen with new plant breeding tool reconstruction of the nasal septum using polydioxanone plate synthetic dissolving plates ease repairs of nasal septum defects association of kras p.g d mutation with outcome in patients with chemotherapy refractory metastatic colorectal cancer treated with cetuximab colorectal cancer patients with gene mutation show better response to cancer agent continuity of sleep problems from adolescence to young adulthood results from a longitudinal study answer to young people s persistent sleep problems trends in the utilization of brachytherapy in cervical cancer in the united states despite higher survival brachytherapy to treat cervical cancer declines in us serotonin is required for exercise induced adult hippocampal neurogenesis serotonin mediates exercise induced generation of new neurons wind and rain are the primary climate factors driving changing phenology of an aerial insectivore wind rain play key role in breeding patterns of migratory tree swallows cadmium free cuins zns quantum dots as efficient and robust photosensitizers in combination with a molecular catalyst for visible light driven h production in water cheaper less toxic and recyclable light absorbers for hydrogen production regulation of active site coupling in glutamine dependent nad synthetase discovery of tuberculosis bacterium enzyme paves way for new tb drugs tissue engineering using autologous microcirculatory beds as vascularized bioscaffolds from stem cells to new organs scientists cross threshold in regenerative medicine acute cardiovascular events after herpes zoster a self controlled case series analysis in vaccinated and unvaccinated older residents of the united states herpes zoster is linked to increased rates of both stroke and myocardial infarction transnational tobacco company interests in smokeless tobacco in europe analysis of internal industry documents and contemporary industry materials tobacco companies interests in smokeless tobacco products in europe are driven by profit not health hormone therapy and the risk of breast cancer in brca mutation carriers hormone therapy may be safe for postmenopausal brca mutation carriers the relationship between the frequency of number puzzle use and baseline cognitive function in a large online sample of adults aged and over regular crosswords and number puzzles linked to sharper brain in later life management and point of care for tobacco dependence prompt a feasibility mixed methods community based participatory action research project in ottawa canada study shows a potential new approach to opioid crisis enhanced re endothelialization of acellular kidney scaffolds for whole organ engineering via antibody conjugation of vasculatures milestone reached in work to build replacement kidneys in the lab flavored alcoholic beverage use risky drinking behaviors and adverse outcomes among underage drinkers results from the abrand study young drinkers of flavored alcohol beverages who only consume supersized versions at increased risk of negative outcomes do time restrictions on alcohol advertising reduce youth exposure ? time restrictions on tv advertisements ineffective in reducing youth exposure to alcohol ads have we substantially underestimated the impact of improved sanitation coverage on child heath ? importance of universal sanitation underestimated in efforts to reduce child mortality tweeting news articles readership and news sections in europe and the americas tweets reveal news readership patterns around the world citywide cluster randomized trial to restore blighted vacant land and its effects on violence crime and fear reduce crime and gun violence and stabilize neighborhoods a randomized controlled study pi k inhibition by idelalisib in patients with relapsed indolent lymphoma new drug shows promise in treating indolent non hodgkin lymphomas evidence for the accretion origin of halo stars with an extreme r process enhancement milky way star with strange chemistry is from dwarf galaxy patent foramen ovale in children with migraine headaches study suggests a relationship between migraine headaches in children and a common heart defect smartphone nanocolorimetry for on demand lead detection and quantitation in drinking water smartphone system to test for lead in water biodiversity of diatom assemblages in a mediterranean semiarid stream implications for conservation biodiversity found in unexpected regions more than plant species found in semi arid rivers in south eastern spain d structures of individual mammalian genomes studied by single cell hi c visualizing the genome first d structures of active dna created high sensitivity c reactive protein in paediatric inflammatory bowel disease c reactive protein measurement in children inflammatory bowel disease patients microbial composition and in vitro fermentation patterns of human milk oligosaccharides and prebiotics differ between formula fed and sow reared piglets breastfeeding benefits human breast milk ingredient adjusts to optimize for beneficial gut bacteria over time control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation new insight into leading viral cause of congenital birth defects the s proteasome is directly involved in the regulation of heterochromatin spreading in fission yeast a molecular garbage disposal complex has a role in packing the genome variation in hospital use of postacute care after surgery and the association with care quality frequent use of post acute care associated with higher hospital readmission rates abcb is a limbal stem cell gene required for corneal development and repair researchers regrow corneas first known tissue grown from an adult human stem cell identifying common patterns in diverse systems effects of exurban development on birds of the adirondack park and the greater yellowstone ecosystem usa are human behaviors affecting bird communities in residential areas ? holocene changes in the trophic ecology of an apex marine predator in the south atlantic ocean massive sea lion fur seal hunting in the patagonian coasts is altering southern atlantic ocean ecosystems advanced biomaterial strategies to transplant preformed micro tissue engineered neural networks into the brain engineered neural networks show hope for axonal repair with minimal disruption to brain tissue county level cumulative environmental quality associated with cancer incidence poor overall environmental quality linked to elevated cancer rates foxa and lipg endothelial lipase control the uptake of extracellular lipids for breast cancer growth breast cancer tumor growth is dependent on lipid availability researchers discover traumatic brain injury increases cortical glutamate network activity by compromising gabaergic control new cell type is implicated in epilepsy caused by traumatic brain injury fear extinction memory consolidation requires potentiation of pontine wave activity during rem sleep potential target to better treat cure anxiety disorders more plant growth but less plant defence ? first global gene expression data for plants grown in soil amended with biochar biochar stimulates more plant growth but less plant defense research shows anxiety symptoms and children s eye gaze during fear learning eye patterns in children the development of anxiety and emotion klotho is a non enzymatic molecular scaffold for fgf hormone signalling anti aging protein alpha klotho s molecular structure revealed deep level defect enhanced photothermal performance of bismuth sulfide gold heterojunction nanorods for photothermal therapy of cancer guided by computed tomography imaging more effective photothermal tumor therapy with infrared light isolation of tumour stem like cells from benign tumours tumor stem like cells exist in benign tumors earliest accumulation of amyloid occurs within the default mode network and concurrently affects brain connectivity new research shows where in the brain the earliest signs of alzheimer s occur directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells turning human stem cells into brain cells sheds light on neural development predictors of early elementary school suspension by gender a longitudinal multilevel analysis suspending young students risks future success in school a genome wide association study identifies cdhr as a susceptibility locus for early childhood asthma with severe exacerbations novel gene variant discovered in severe childhood asthma experimental adaptation of an influenza h ha confers respiratory droplet transmission to a reassortant h ha h n virus in ferrets after epic debate avian flu research sees light of day role of syn eruptive plagioclase disequilibrium crystallization in basaltic magma ascent dynamics clues from past volcanic explosion helps research team to model future activity oxidase deficient neutrophils from x linked chronic granulomatous disease ips cells functional correction by zinc finger nuclease mediated safe harbor targeting new gene therapy technique on ips cells holds promise in treating immune system disease it s now or never fertility related knowledge decision making preferences and treatment intentions in young women with breast cancer an australian fertility decision aid collaborative group study young women with breast cancer have little fertility knowledge australian survey finds the world s tallest trees grow in thermally similar climates temperature most significant driver of world s tallest trees aerobic exercise moderates the effect of heavy alcohol consumption on white matter damage aerobic exercise may protect cognitive abilities of heavy drinkers oral contraceptives impair complex emotion recognition in healthy women oral contraceptives could impair women s recognition of complex emotions the optaids project towards global halting of hiv aids immediate aggressive spending on hiv aids could end epidemic plasmid templated shape control of condensed dna block copolymer nanoparticles shape matters in dna nanoparticle therapy particles could become a safer more effective delivery vehicle for gene therapy the changing career trajectories of new parents in stem parenthood contributes to gender imbalance in stem employment but it s not just an issue for mother problematic use of social networking sites antecedents and consequence from a dual system theory perspective problematic social media use linked to brain imbalance a biphasic scaffold based on silk and bioactive ceramic with stratified properties for osteochondral tissue regeneration silk and ceramics offer hope for long term repair of joint injuries survival and habitat selection of canada geese during autumn and winter in metropolitan chicago usa smart birds canada geese give hunters the slip by hiding out in chicago development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy cat allergy vaccine safe and effective study suggests longitudinal analysis of patient reported outcomes and cosmesis in a randomized trial of conventionally fractionated versus hypofractionated whole breast irradiation shorter radiation course recommended for early stage breast cancer patients obstructive sleep apnea and inflammation proof of concept based on two illustrative cytokines obstructive sleep apnea linked to inflammation organ dysfunction early socioeconomic adversity and young adult physical illness the role of body mass index and depressive symptoms growing up poor impacts physical mental illness in young adults reduced brain glutamine in female varsity rugby athletes after concussion and in non concussed athletes after a season of play female rugby players shows a regular season of play results in changes in brain a model for neural development and treatment of rett syndrome using human induced pluripotent stem cells modeling autism in a lab dish researchers create autistic neuron model retrospective dosimetry at the natural background level with commercial surface mount resistors new technique offers rapid assessment of radiation exposure autism spectrum symptoms in a tourette s disorder sample elevated rate of autism symptoms found in children with tourette syndrome documenting neotropical diversity of phoronids with dna barcoding of planktonic larvae parents unknown mysterious larvae found in panama s two oceans development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long term expandability new method to grow womb lining and mimic menstrual cycle in the laboratory dish driving ability reported by neovascular age related macular degeneration patients after treatment with ranibizumab monoclonal antibody fragment treatments for wet macular degeneration keep elderly drivers behind the wheel study suggests aromatase inhibitors versus tamoxifen in early breast cancer patient level meta analysis of the randomised trials two classes of inexpensive generic drugs can reduce breast cancer deaths new research shows nrf dependent suppression of azoxymethane dextran sulfate sodium induced colon carcinogenesis by the cinnamon derived dietary factor cinnamaldehyde researchers discover component of cinnamon prevents colorectal cancer in mice dissecting the roles of raf and pi k signalling pathways in melanoma formation and progression in a zebrafish model zebrafish provide model for cancerous melanoma in humans comparison of us emergency department acute asthma care quality and inconsistent achievement of guidelines for acute asthma care found in hospital eds comparison of nutrition and lung function outcomes in patients with cystic fibrosis living in canada and the united states. health of people with cystic fibrosis shows positive trends in us and canada impact of soybean cyst nematode resistance on soybean yield nematode resistance in soybeans beneficial even at low rates of infestation impact of treated wastewater irrigation on antibiotic resistance in agricultural soils good news on using recycled sewage treatment plant water for irrigating crops lacosamide as adjunctive therapy for partial onset seizures a randomized controlled trial lacosamide validated as promising therapy for uncontrolled partial onset seizures rapid decay in the relative efficiency of quarantine to halt epidemics in networks prevention is better than cure targeted vaccination to halt epidemics burden of geriatric events among older adults undergoing major cancer surgery injuries other health concerns are more common in older people after certain cancer surgeries associations between lgbtq affirmative school climate and adolescent drinking behaviors students binge drink less in locales with more affirmative lgbtq school climates electrical appliances moderate households water demand response to heat in response to heat the more affluent use air conditioners low income households use water fast clonal expansion and limited neural stem cell self renewal in the adult subependymal zone stem cells in the brain limited self renewal single nucleotide polymorphisms in taste receptor genes are associated with snacking patterns of preschool aged children in the guelph family health study a pilot study sweet bitter fat genetics play a role in kids snacking patterns early clinical predictors of year outcome after concussive blast traumatic brain injury worsening outcomes in service members five years after mild blast induced concussion delayed disease onset and extended survival in the sod g a rat model of amyotrophic lateral sclerosis after suppression of mutant sod in the motor cortex study of lou gehrig s disease shifts origin focus to brain s motor neurons peripheral pulse measurement after ischemic stroke a feasibility study monitoring pulse after stroke may prevent a second stroke pandemic h n influenza infection and vaccination in humans induces cross protective antibodies that target the hemagglutinin stem h n discovery paves way for universal flu vaccine extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade unique protein demystifying the resilience of water bears protein protects human cultured cells from radiation damage immune response to cystoisospora suis in piglets local and systemic changes in t cell subsets and selected mrna transcripts in the small intestine piglet health a better understanding of the immune response to intestinal parasites venous thrombosis in users of non oral hormonal contraception follow up study denmark more evidence on clot risks of non oral contraceptives artificial neural network approach to predict the elastic modulus from dynamic mechanical analysis results researchers use artificial neural networks to streamline materials testing the dna methylome of human peripheral blood mononuclear cells human methylome sequenced at single base pair resolution cranial biomechanics of diplodocus dinosauria sauropoda testing hypotheses of feeding behaviour in an extinct megaherbivore engineering technology reveals eating habits of giant dinosaurs complex mixtures of brominated chlorinated diphenyl ethers and dibenzofurans in soils from the agbogbloshie e waste site ghana occurrence formation and exposure implications characterization of hidden dioxins from informal e waste processing cannabis use during the perinatal period in a state with legalized recreational and medical marijuana the association between maternal characteristics breastfeeding patterns and neonatal outcomes prenatal cannabis use associated with low birth weights prevention of hyperglycemia induced myocardial apoptosis by gene silencing of toll like receptor gene knockout shows potential for diabetes related heart failure diverse genome wide association studies associate the il pathway with crohn s disease new gene searching method uncovers possible new targets for crohn s disease drugs open ocean fish reveal an omnidirectional solution to camouflage in polarized environments new camouflage mechanism fish use in the open ocean a randomized trial of the effect of e cigarette tv advertisements on intentions to use e cigarettes adolescent exposure to e cigarette tv ads increases likelihood of future use maternal fructose drives placental uric acid production leading to adverse fetal outcomes high fructose diet during pregnancy may harm placenta restrict fetal growth dancing backwards in high heels female professors experience more work demands and special favor requests particularly from academically entitled students female professors are asked for favors more often than male professors hypoxic pulmonary vasoconstriction requires connexin mediated endothelial signal conduction research findings breathe new life into lung disease epigenetic changes associated with inflammation in breast cancer patients treated with chemotherapy imprint of chemotherapy linked to inflammation in breast cancer survivors neuroticism influences brain activity during the experience of visceral pain negative emotions influence brain activity during anticipation and experience of pain preliminary survey of ectoparasites and associated pathogens from norway rats in new york city disease carrying fleas abound on new york city s rats cytotoxic cd t cells stimulate hematopoietic progenitors by promoting cytokine release from bone marrow mesenchymal stromal cells immune cells regulate blood stem cells research shows prenatal and postnatal tobacco exposure and behavioral problems in year old children results from the gini plus prospective birth cohort study study confirms association between tobacco smoke and behavioral problems in children we wait the impact of character responsiveness and self embodiment on presence and interest in an immersive news experience good news for immersive journalism look at your audience thar she blows ! a novel method for dna collection from cetacean blow thar she blows ! novel method for collecting dolphin dna fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy cancer death button gets jammed by gut bacterium the influence of legacy p on lake water quality in a midwestern agricultural watershed study quantifies effect of legacy phosphorus in reduced water quality introgression of regulatory alleles and a missense coding mutation drive plumage pattern diversity in the rock pigeon variations of a single gene drive diverse pigeon feather patterns late pleistocene archaic human crania from xuchang china year old human skulls from east asia reveal complex mix of trends in time space reducing distress in mothers of children with autism and other disabilities a randomized trial mothers of children with autism benefit from peer led intervention urban and nomadic isotopic niches reveal dietary connectivities along central asia s silk roads compared to nomadic communities silk road cities were urban food deserts non steroidal anti inflammatory drug use is associated with increased risk of out of hospital cardiac arrest a nationwide case time control study harmless painkillers associated with increased risk of cardiac arrest radical cystectomy compared to combined modality treatment for muscle invasive bladder cancer a systematic review and meta analysis combined modality treatment could be first course for muscle invasive bladder cancer response of coral reefs to climate change expansion and demise of the southernmost pacific coral reef extensive relict coral reef found in southern pacific herpesviruses in endodontic pathoses association of epstein barr virus with irreversible pulpitis and apical periodontitis epstein barr virus associated with inflammatory diseases of the mouth prolonged shedding of zika virus associated with congenital infection zika virus detected in newborn until months after birth bap links metabolic regulation of ferroptosis to tumour suppression study links bap protein to tumor suppression in kidney eye bile duct and mesothelioma cancers beyond genotype serotonin transporter epigenetic modification predicts human brain function small dna modifications predict brain s threat response discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation new material forges the way for stem cell factories mindfulness meditation for medical students a student led initiative to expose medical students to mindfulness practices for busy medical students two hour meditation study may be as beneficial as longer course legislative smoking bans for reducing harms from secondhand smoke exposure smoking prevalence and tobacco consumption have national smoking bans worked in reducing harms in passive smoking ? make data sharing routine to prepare for public health emergencies data sharing should become routine for best reponse to public health emergencies potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte derived dendritic cells can probiotic bacteria induce monocyte derived dendritic cells maturation ? risk factors for year prospective height loss among postmenopausal women strenuous exercise in adolescence may ward off height loss later in life expectations of brilliance underlie gender distributions across academic disciplines study supports new explanation of gender gaps in academia block of a astrocyte conversion by microglia is neuroprotective in models of parkinson s disease experimental drug stops parkinson s disease progression in mice olfactory receptor subgenomes linked with broad ecological adaptations in sauropsida study of birds sense of smell reveals important clues for behavior adaptation atrial like engineered heart tissue an in vitro model of the human atrium watch a d engineered human heart tissue beat low dimensional clustering detects incipient dominant influenza strain clusters new way of predicting dominant seasonal flu strain delayed diagnosis and a lack of information associated with dissatisfaction in women with polycystic ovary syndrome women dissatisfied with long process to diagnose polycystic ovary syndrome evaluating the promise and pitfalls of a potential climate change tolerant sea urchin fishery in southern california tasty and pink sea urchin species may be a climate tolerant food source traffic related air pollution apoe status and neurodevelopmental outcomes among school children enrolled in the breathe project catalonia spain risk gene for alzheimer s may aggravate neurological effects of air pollution in children systemic peptide mediated oligonucleotide therapy improves long term survival in spinal muscular atrophy trial offers hope of a treatment for spinal muscular atrophy fgf has distinct molecular functions from gdnf in the mouse germline niche the novel function of self renewal factor of spermatogonial stem cells is identified aggressive triple negative breast cancers have unique molecular signature on the basis of mitochondrial genetic and functional defects therapeutic targets for aggressive triple negative breast cancers prevalence of overweight and obesity in the united states prevalence of overweight obesity in the united states impact of the american college of surgeons oncology group z criteria applied to a contemporary patient population limited lymph node removal effective for most women with early stage breast cancer and positive sentinel lymph nodes inducible caspase suicide gene controls adverse effects from alloreplete t cells after haploidentical stem cell transplantation safety switch preserves beneficial effects of cell therapy coarse particulate matter pm. in los angeles basin air induces expression of inflammation and cancer biomarkers in rat brains prolonged exposure to air pollution leads to genetic changes in rat brains study finds novel approaches reveal thattoxoplasma gondiibradyzoites within tissue cysts are dynamic and replicating entitiesin vivo researchers find dormant parasite cysts are actually quite active the chloroplast genome sequence of bittersweet solanum dulcamara plastid genome structure evolution in solanaceae a simple software error corrected bittersweet chloroplast genome becomes the model ptbp controls an alternative splicing network required for cell communication during spermatogenesis single protein controls genetic network essential for sperm development secondhand smoke and sensorineural hearing loss in adolescents exposure to secondhand smoke associated with hearing loss in adolescents resting zone of the growth plate houses a unique class of skeletal stem cells unique type of skeletal stem cells found in resting zone are actually hard at work serial neuroimaging in infants with abusive head trauma timing abusive injuries using serial neuroimaging studies to identify timing of abusive head trauma in infants refinement in localization and identification of gene regions associated with crohn disease more than genes identified for crohn s disease prayer attachment to god and symptoms of anxiety related disorders among u.s. adults anxiety and amen prayer doesn t ease symptoms of anxiety related disorders for everyone drinking to belong the effect of a friendship threat and self esteem on college student drinking drinking to belong students and low self esteem transient low doses of dna demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells scientists reprogram cancer cells with low doses of epigenetic drugs modeling smith lemli opitz syndrome with induced pluripotent stem cells reveals a causal role for wnt catenin defects in neuronal cholesterol synthesis phenotypes scientist models smith lemli opitz syndrome in adult stem cells american heart association and nonprofit advocacy past present and future a policy recommendation from the american heart association advocacy in tight fiscal environment vital to reducing heart disease and stroke safety and immunogenicity of a novel recombinant adenovirus type vector based ebola vaccine in healthy adults in china preliminary report of a randomised double blind placebo controlled phase trial phase trial of first ebola vaccine based on virus strain shows vaccine is safe and provokes an immune response increased health burden associated with clostridium difficile diarrhoea in patients with inflammatory bowel disease c. difficile increases risk of death six fold in patients with inflammatory bowel disease using emr to improve compliance with clinical practice guidelines for management of stable copd guides within electronic medical records during visits help doctors provide better care volcanic drumbeat seismicity caused by stick slip motion and magmatic frictional melting new insight may help predict volcanic eruption behavior social media censorship in times of political unrest a social simulation experiment with the uk riots censoring social media fans flames of social unrest epigenomic analysis of multilineage differentiation of human embryonic stem cells epigenomics of stem cells that mimic early human development charted transient pairing of homologous oct alleles accompanies the onset of embryonic stem cell differentiation twin copies of gene pair up in embryonic stem cells at critical moment in differentiation enhanced striatal dopamine release to expectation of alcohol a potential risk factor for alcohol use disorder people with family history of alcoholism release more dopamine in expectation of alcohol trends in physical dating violence victimization among u.s. high school students study finds one in high school students hurt by dating partners behavioral responses to mammalian blood odor and a blood odor component in four species of large carnivores odor that smells like blood single component powerful trigger for large carnivores urban mining of e waste is becoming more cost effective than virgin mining pulling valuable metals from e waste makes financial sense evaluation of a flipped classroom approach to learning introductory epidemiology flipping the classroom approach in public health does student performance improve ? a high performance neural prosthesis enabled by control algorithm design leap forward in brain controlled computer cursors new algorithm greatly improves speed and accuracy neutrophil histone modification by peptidylarginine deiminase is critical for deep vein thrombosis in mice gene offers clues to new treatments for a harmful blood clotting disorder nuclear receptor nr h in familial multiple sclerosis first gene mutation explaining development of multiple sclerosis effect of dispersion on solutal convection in porous media table top experiment flips current understanding of solutal convection auditory nerve perinodal dysmyelination in noise induced hearing loss tinnitus study signals new advance in understanding link between exposure to loud sounds and hearing loss hepatocyte growth factor a determinant of airspace homeostasis in the murine lung lung researchers create new air sacs in mouse model of emphysema using a novel growth factor pharmacogenetic meta analysis of genome wide association studies of ldl cholesterol response to statins genetic variants influence a person s response to statins found ethosuximide valproic acid and lamotrigine in childhood absence epilepsy comparative effectiveness trial leads to evidence based care for childhood epilepsy mutant trp exerts a target gene selective dominant negative effect to drive tumor development mutant protein tackles dna guardian to promote cancer development mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma amplification of multiple cell growth genes found in some brain tumors predictive values of psychiatric symptoms for internet addiction in adolescents a year prospective study psychiatric symptoms may predict internet addiction in adolescents home based versus mobile clinic hiv testing and counseling in rural lesotho a cluster randomized trial home versus mobile clinic based hiv testing and counseling in rural africa response of seaward migrating european eel anguilla anguilla to manipulated flow fields researchers go with the flow to help protect endangered european eel threat to future global food security from climate change and ozone air pollution climate change and air pollution will combine to curb food supplies effects of sandfish holothuria scabra removal on shallow water sediments in fiji study in fiji finds that removing sea cucumbers spells trouble for shallow coastal waters collective intelligence meets medical decision making the collective outperforms the best radiologist collective intelligence helps to improve breast cancer diagnosis discovery of common chemical exposures across three continents using silicone wristbands wristband samplers show similar chemical exposure across three continents mechanistic modeling of hemoglobin glycation and red blood cell kinetics enables personalized diabetes monitoring sweet math scientists devise a more accurate way to gauge blood sugar averages in people with diabetes dna barcode identification of lichen forming fungal species in the rhizoplaca melanophthalma species complex lecanorales lecanoraceae including five new species revealing hidden fungal species using dna the importance of recognizing cryptic diversity comparison of the genomic landscape between primary breast cancer in african american versus white women and the association of racial differences with tumor recurrence genomic differences between breast cancers of african american white women identified weight change in breast cancer survivors compared to cancer free women a prospective study in women at familial risk of breast cancer breast cancer survivors gain weight at a higher rate than their cancer free peers gata controls the maintenance and proliferation of t cells downstream of tcr and cytokine signaling gata is important for regulation and maintenance of immune system self reported adverse tattoo reactions a new york city central park study tattoos may come with long term medical risks physicians warn inactivation of the ubiquitin specific protease deubiquitinating enzyme protects against muscle wasting research breakthrough in fight against muscle wasting diseases a sox distal enhancer cluster regulates embryonic stem cell differentiation potential cell biologists discover on off switch for key stem cell gene horizontal genome transfer as an asexual path to the formation of new species making new species without sex plants can transfer their entire genetic material to a partner in an asexual manner a comparison of payments to a for profit dialysis firm from government and commercial insurers for profit dialysis provider charges private insurers times more than government payers emergence of hierarchical structural complexities in nanoparticles and their assembly synthetic nanoparticles achieve the complexity of protein molecules deep water circulation changes lead north atlantic climate during deglaciation changes in ocean conveyor belt foretold abrupt climate changes by four centuries weight loss associated with cholinesterase inhibitors in individuals with dementia in a national healthcare system common medications for dementia could cause harmful weight loss community based preclinical patient navigation for colorectal cancer screening among older black men recruited from barbershops the mister b trial reaching black men in barbershops could lead to early detection of colorectal cancer long term effects of increased protein intake after weight loss on intrahepatic lipid content and implications for insulin sensitivity a preview study more protein after weight loss may reduce fatty liver disease impaired enolase glycolytic activity restrains effector functions of tumor infiltrating cd t cells secret to making immune cells better cancer killers process development for hydrothermal liquefaction of algae feedstocks in a continuous flow reactor algae to crude oil million year natural process takes minutes in the lab a prostate cancer composite score to identify high burden neighborhoods new metric defines areas of highest prostate cancer burden cingulum stimulation enhances positive affect and anxiolysis to facilitate awake craniotomy laughter may be best medicine for brain surgery short and long term labile soil carbon and nitrogen dynamics reflect management and predict corn agronomic performance can simple measures of labile soil organic matter predict corn performance ? amphibians in the climate vise loss and restoration of resilience of montane wetland ecosystems in the western us amphibians in a vice climate change robs frogs salamanders of refuge prognosis of severe asymptomatic aortic stenosis with and without surgery early valve replacement versus watchful waiting in patients with severe aortic stenosis increased chemerin and decreased omentin in both adipose tissue and plasma in nascent metabolic syndrome study deflates notion that pear shaped bodies more healthy than apples abnormal proteins from buttock fat linked to metabolic syndrome development of a d printed bioengineered placenta model to evaluate the role of trophoblast migration in preeclampsia d bioprinted placenta could lead to new treatments for preeclampsia injuries associated with bottles pacifiers and sippy cups in the united states injuries associated with baby bottles pacifiers and sippy cups in the u.s. surprisingly high anin vitromethod for determining the bioaccessibility of pharmaceuticals in wildlife what happens to pharmaceuticals in the digestive system of a bird ? inhibition of cgas dna sensing by a herpesvirus virion protein scientists identify possible key in virus cancer research encapsulation free controlled release electrostatic adsorption eliminates the need for protein encapsulation in plga nanoparticles simple attraction researchers control protein release from nanoparticles without encapsulation tracing the climate signal mitigation of anthropogenic methane emissions can outweigh a large arctic natural emission increase diffusing the methane bomb we can still make a difference a statistical comparative planetology approach to the hunt for habitable exoplanets and life beyond the solar system search for earth like planets try a statistical approach prenatal exposure to methyl mercury from fish consumption and polyunsaturated fatty acids associations with child development at mo of age in an observational study in the republic of seychelles fatty acids in fish may shield brain from mercury damage are we educating educators about academic integrity ? a study of uk higher education textbooks are we educating educators about academic integrity ? once bitten twice shy concern about gaining weight after smoking cessation and its association with seeking treatment risk of weight gain deters some smokers from seeking treatment to quit rational design of an epstein barr virus vaccine targeting the receptor binding site epstein barr virus vaccine elicits potent neutralizing antibodies in animals a new species of the bay goby genus eucyclogobius endemic to southern california evolution conservation and decline morphology suggests an endangered goby in southern california is a new species control of oriented tissue growth through repression of organ boundary genes promotes stem morphogenesis peeling back the layers scientists use new techniques to uncover hidden secrets of plant stem development a revision of the genus arenivaga rehn blattodea corydiidae with descriptions of new species and key to the males of the genus thirty nine new species of endemic cockroach discovered in the southwestern us and mexico deployment and mental health diagnoses among children of us army personnel length of parental military deployment associated with children s mental health diagnoses study finds cell lineage heterogeneity and driver mutation recurrence in pre invasive breast neoplasia we may be looking at wrong mutation for breast cancer treatment immunity to measles mumps and rubella in us children with perinatal hiv infection or perinatal hiv exposure without infection large percentage of youth with hiv may lack immunity to measles mumps rubella integrating gwass and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence study finds gene network associated with alcohol dependence prevalence of infertility and help seeking among women and men survey of women and men reveals scale of infertility intricate and cell type specific populations of endogenous circular dna eccdna in caenorhabditis elegans and homo sapiens study of circular dna comes full circle with use of old technique the one two punch of alcoholism role of central amygdala dynorphins kappa opioid receptors alcoholism treatment kappa opioid receptors a new target late hemphillian colubrid snakes serpentes colubridae from the gray fossil site of northeastern tennessee fossil winged serpent is a new species of ancient snake hospital complication rates with bariatric surgery in michigan study examines hospital complication rates of bariatric surgery paracrine apoptotic effect of p mediated by tumor suppressor par new study shows promise for preventing therapy resistance in tumor cells pathoanatomic findings associated with duty related cardiac death in us firefighters a case control study heart disease common among firefighters who die of cardiac arrest monitoring the development of xenograft triple negative breast cancer models using diffusion weighted magnetic resonance imaging improving the development of new cancer models using an advanced biomedical imaging method genomic basis for coral resilience to climate change heat resistant corals provide clues to climate change survival out of the tropics the pacific great basin lakes and late pleistocene water cycle in the western united states new clues about ancient water cycles shed light on u.s. deserts injuries before and after diagnosis of cancer nationwide register based study patients with cancer at heightened risk of injuries during diagnosis reported traumatic injuries among west coast dungeness crab fishermen injuries among dungeness crab fishermen examined in new study bionic reconstruction to restore hand function after brachial plexus injury a case series of three patients bionic reconstruction lets patients use a robotic prosthetic hand controlled by the mind interplay between bladder microbiota and urinary antimicrobial peptides mechanisms for human urinary tract infection risk and symptom severity method to assess uti risk in women after pelvic floor surgery activated cd ccr t cells in the rectum predict increased siv acquisition in sivgag tat vaccinated rhesus macaques hiv vaccines should avoid viral target cells primate model study suggests bone cell independent benefits of raloxifene on the skeleton a novel mechanism for improving bone material properties revealing novel mode of action for osteoporosis drug the top classic papers in lumbar spine surgery top papers in lumbar spine surgery reflect trends in low back pain treatment selection of discriminant markers for authentication of asian palm civet coffee kopi luwak a metabolomics approach first scientific method to authenticate world s costliest coffee from the feces of the palm civet effect of rare variants in adrb on risk of severe exacerbations and symptom control during longacting agonist treatment in a multiethnic asthma population a genetic study rare genetic variations may account for life threatening reaction to long acting beta agonist drugs in some people a lifetime of changing calls north atlantic right whales eubalaena glacialis refine call production as they age voice control why north atlantic right whales change calls as they age current understanding and challenges for oceans in a higher co world ocean acidification a challenge for science governments and communities the parp inhibitor olaparib enhances the sensitivity of ewing sarcoma to trabectedin potential treatment option for children with ewing s sarcoma origins and genetic diversity among atlantic salmon recolonizing upstream areas of a large south european river following restoration of connectivity and stocking salmon recolonizing newly reconnected zones in rivers of adour basin transcatheter aortic valve replacement versus surgical valve replacement in intermediate risk patients a propensity score analysis transcatheter aortic valve replacement better for patients with severe aortic stenosis study finds engineering a highly elastic human protein based sealant for surgical applications squirtable elastic surgical glue seals wounds in seconds the missing omes proposing social and environmental nomenclature in precision medicine proposal urges stronger focus on social and environmental factors in precision medicine early detection and treatment of wear particle induced inflammation and bone loss in a mouse calvarial osteolysis model using hpma copolymer conjugates new test shows promise for detecting warning signs of joint replacement failure electronic cigarette use among korean adolescents a cross sectional study of market penetration dual use and relationship to quit attempts and former smoking electronic cigarettes new route to smoking addiction for adolescents cd plays a protective role in experimental inflammatory bowel disease by enhancing intestinal barrier function genetic link to susceptibility and resistance to inflammatory bowel disease pericyte loss influences alzheimer like neurodegeneration in mice study breaks blood brain barriers to understanding alzheimer s the phantom vanish magic trick investigating the disappearance of a non existent object in a dynamic scene psychologist s magic makes a non existent object disappear efficacy and safety of a drug fixed dose combination regimen compared with separate drugs for treatment of pulmonary tuberculosis the study c randomized controlled trial use of combination drug regimen for treating tb may represent an effective treatment option a new scale for assessing wisdom based on common domains and a neurobiological model the san diego wisdom scale sd wise new tool to assess individual s level of wisdom the role of small scale fold and fault development in seismogenic zones example of the western huercal overa basin eastern betic cordillera spain small faults in southeast spain reduce earthquake risk of larger ones a canonical to non canonical wnt signalling switch in haematopoietic stem cell ageing blood stem cells age at the unexpected flip of a molecular switch auxin regulated chromatin switch directs acquisition of flower primordium founder fate plant hormone switch unravels chromatin to form flowers biologists find antidepressant use during pregnancy and the risk of autism spectrum disorder in children taking antidepressants during pregnancy increases risk of autism by percent warming of subarctic tundra increases emissions of all three important greenhouse gases carbon dioxide methane and nitrous oxide enhanced nitrous oxide emissions found in field warming experiment in the arctic extended measurement of the cosmic ray electron and positron spectrum from gev to. tev with the calorimetric electron telescope on the international space station calet succeeds in direct measurements of cosmic ray electron spectrum up to. tev impact of treatment delay on mortality in st segment elevation myocardial infarction stemi patients presenting with and without haemodynamic instability results from the german prospective multicentre fitt stemi trial shorter time between first medical contact to pci in heart patients linked to saving lives molecular and cellular reorganization of neural circuits in the human lineage small but distinct differences among species mark evolution of human brain efficient targeting of expressed and silent genes in human escs and ipscs using zinc finger nucleases technique enables efficient gene splicing in human embryonic stem cells exposure to tobacco smoke prenatally and during infancy and risk of hearing impairment among children in japan a retrospective cohort study exposure to smoking before and after birth linked to hearing impairment in toddlers genetic and clinical factors associated with chronic postsurgical pain after hernia repair hysterectomy and thoracotomy a two year multicenter cohort study new scoring system helps predict risk of chronic pain after surgery varicella zoster virus specific immune responses to a herpes zoster vaccine in elderly recipients with major depression and the impact of antidepressant medications study suggests link between untreated depression and response to shingles vaccine tenofovir based preexposure prophylaxis for hiv infection among african women final results of the hiv prevention study voice published economic impact of dengue illness in the americas economic impact of dengue virus in americas. billion per year study finds emergency department implementation of the centers for disease control and prevention pediatric mild traumatic brain injury guideline recommendations new cdc guidelines detail treatment of pediatric mild traumatic brain injury cannabidiol in patients with treatment resistant epilepsy an open label interventional trial marijuana derivative reduces seizures in people with treatment resistant epilepsy endocranial anatomy of antarctic eocene stem penguins implications for sensory system evolution in sphenisciformes aves new fossil skulls reveal insights about penguin brain evolution structure of the core ectodomain of the hepatitis c virus envelope glycoprotein structure of virus identified that could lead to hepatitis c vaccine in host adaptation and acquired triazole resistance in aspergillus fumigatus a dilemma for clinical management rapid adaptation of aspergillus fungus presents doctors with a dilemma epidermal growth factor regulates hematopoietic regeneration after radiation injury growth factor aids stem cell regeneration after radiation damage quantifying loss of acoustic communication space for right whales in and around a u.s. national marine sanctuary underwater noise decreases whale communications in stellwagen bank sanctuary access to healthy food stores modifies effect of a dietary intervention even motivated dieters need close access to healthy food the paracrine hormone for the gucy c tumor suppressor guanylin is universally lost in colorectal cancer hormone loss could be involved in colon cancer rapid discovery and structure activity relationships of pyrazolopyrimidines that potently suppress breast cancer cell growth via src kinase inhibition with exceptional selectivity over abl kinase breast cancer drug discovery offers hope of new treatments limiting global mean temperature increase to. c could reduce the incidence and spatial spread of dengue fever in latin america limiting global warming could avoid millions of dengue fever cases cockroach mediated seed dispersal in monotropastrum humile ericaceae a new mutualistic mechanism cockroach gardeners spreading plant seeds across the forest floor functional igf r variant predicts breast cancer risk in women with preeclampsia in california teachers study some women with history of pre eclampsia have significantly lower risk for breast cancer thousands of microbial genomes shed light on interconnected biogeochemical processes in an aquifer system new bacteria groups and stunning diversity discovered underground vulnerability to forest loss through altered postfire recovery dynamics in a warming climate in the klamath mountains scientists examine impact of high severity fires on conifer forests defective transcytosis of app and lipoproteins in human ipsc derived neurons with familial alzheimer s disease mutations dysfunction in neuronal transport mechanism linked to alzheimer s disease hydroxyurea is associated with lower costs of care of young children with sickle cell anemia drug reduces hospitalizations and cost of treating young children with sickle cell anemia on the identity of leptoxis taeniata a misapplied name for the threatened painted rocksnail cerithioidea pleuroceridae threatened alabama snail renamed after a case of mistaken identity improving folate vitamin b stability in biofortified rice through metabolic engineering scientists create rice variety with high folate stability dodging silver bullets good crispr gene drive design is critical for eradicating exotic vertebrates eradicating exotic pests with infertility genes may be possible development and certification of a standard reference material for vitamin d metabolites in human serum new standard for vitamin d testing to ensure accurate test results effects of a sweetpotato protein digest on lipid metabolism in mice administered a high fat diet the secret slimming effect of sweet potato waste quality of care for older adults with chronic obstructive pulmonary disease and asthma based on comparisons to practice guidelines and smoking status guidelines for care of elderly patients routinely ignored study shows the extended iself the impact of iphone separation on cognition emotion and physiology iphone separation linked to physiological anxiety poor cognitive performance fragile x proteins fmrp and fxr p control synaptic glua expression and neuronal maturation via distinct mechanisms fragile x proteins involved in proper neuron development win concurrent sensory cues can promote riskier choice casino lights and sounds encourage risky decision making can patients make recordings of medical encounters ?what does the law say ? can patients record doctor s visits ? what does the law say ? nonpathogenic mycobacterium brumae inhibits bladder cancer growth in vitro ex vivo and in vivo possible new treatment for bladder cancer using a mycobacterium building agent based decision support systems for word of mouth programs. a freemium application new technique could boost online word of mouth marketing survey of tail injuries sustained by working gundogs and terriers in scotland undocked working dogs at greatest risk of tail injuries in scotland toward efficient optical trapping of sub nm particles with coaxial plasmonic apertures new optical tweezers trap specimens just a few nanometers across early onset depressive disorders predict the use of addictive substances in adolescence a prospective study of adolescent finnish twins early onset depressive disorders predict the use of addictive substances in adolescence changes in macrophage transcriptome associate with systemic sclerosis and mediategsdmacontribution to disease risk genomics reveals key macrophages involvement in systemic sclerosis endogenous adenosine a receptor activation selectively alleviates persistent pain states off switch for pain discovered activating the adenosine a receptor subtype is key to powerful pain relief purkinje cells derived from tsc patients display hypoexcitability and synaptic deficits associated with reduced fmrp levels and reversed by rapamycin lab grown human cerebellar cells yield clues to autism resilience in context a brief and culturally grounded measure for syrian refugee and jordanian host community adolescents new tool measures resilience in adolescent syrian refugees transport networks and inequities in vaccination remoteness shapes measles vaccine coverage and prospects for elimination across africa expanding age of eligibility for measles vaccination could increase childhood survival in africa a novel computational biostatistics approach implies impaired dephosphorylation of growth factor receptors as associated with severity of autism biostatistics approach to genetics yields new clues to roots of autism daily couple experiences and parent affect in families of children with versus without autism insight into day to day lives of parents raising children with autism the impact of socioeconomic status on survival after cancer in the united states findings from the national program of cancer registries patterns of care study low socioeconomic status increases risk of death after cancer diagnosis making the most of the affordable care act s contraceptive coverage mandate for privately insured women women will benefit from the affordable care act s contraceptive coverage social interactions among grazing reef fish drive material flux in a coral reef ecosystem fish social lives may be key to saving coral reefs economic performance of long term organic and conventional cropping systems in minnesota economic analysis reveals organic farming profitable long term improving care for people with dementia development and initial feasibility study for evaluation of life story work in dementia care living with dementia life story work proves successful early primary care provider follow up and readmission after high risk surgery early post surgery follow up visits to primary care physicians cuts hospital readmissions dominance of tensor correlations in high momentum nucleon pairs studied by p pd reaction proton scattering reveals the secrets of strongly correlated proton neutron pairs in atomic nuclei a compact tunable quadrupole lens for brighter and sharper ultra fast electron diffraction imaging new lens system for brighter sharper diffraction images extended operational lifetime of a photosystem based bioelectrode improving the lifetime of bioelectrodes for solar energy conversion arabidopsis r r r myb proteins are essential for inhibiting cell division in response to dna damage plant cells survive but stop dividing upon dna damage d cycloserine facilitates socially reinforced learning in an animal model relevant to autism spectrum disorders social bonding in prairie voles helps guide search for autism treatments an evidence based systematic review on medical therapies for inflammatory bowel disease digestive experts grade treatment options for inflammatory bowel disease high fructose diet in pregnancy leads to fetal programming of hypertension insulin resistance and obesity in adult offspring consuming too much fructose during pregnancy raises the child s risk for heart disease geochemical triggers of arsenic mobilization during managed aquifer recharge soil sleuths solve mystery of arsenic contaminated water helistroke neurointerventionalist helicopter transport for interventional stroke treatment proof of concept and rationale helistroke service flying the physician to the stroke patient works duration of red blood cell storage is associated with increased incidence of deep vein thrombosis and in hospital mortality in patients with traumatic injuries old red blood cells may double mortality in trauma patients the training concept improves performance and health profile in moderately trained runners runners can improve health and performance with less training study shows tocotrienol vitamin e protects against preclinical canine ischemic stroke by inducing arteriogenesis preventive use of one form of natural vitamin e may reduce stroke damage measuring intraspecific variation in flight related morphology of monarch butterflies danaus plexippus which sex has the best flying gear ? wing structure helps female monarch butterflies outperform males in flight recommendations on screening for colorectal cancer in primary care new canadian recommendation against colonoscopy for routine screening of colorectal cancer amphiphilic nanocarrier induced modulation of plk and mir a leads to improved therapeutic response in pancreatic cancer novel nanomedicine inhibits progression of pancreatic cancer in mice vitamins c and e to prevent complications of pregnancy associated hypertension vitamin c and e supplements do not reduce risk for blood pressure disorders of pregnancy study suggests the association of depression and anxiety with glycemic control among mexican americans with diabetes living near the u.s. mexico border depression anxiety linked to poor diabetes management among mexican americans an expressive therapy group disclosure intervention for women living with hiv improves social support self efficacy and the safety and quality of relationships a qualitative analysis expressive therapy intervention assists women living with hiv artists before columbus a multi method characterization of the materials and practices of caribbean cave art caribbean s largest concentration of indigenous pre columbian rock art rapid inflammasome activation following mucosal siv infection of rhesus monkeys researchers uncover earliest events following hiv infection before virus is detectable concordance with world cancer research fund american institute for cancer research wcrf aicr guidelines for cancer prevention and obesity related cancer risk in the framingham offspring cohort. hexdec. cancer prevention guidelines may lower risk of obesity linked cancers neurocognitive test performance and symptom reporting in cheerleaders with concussions neurocognitive testing more accurate than self reporting when assessing concussion recovery in cheerleaders do children with blunt head trauma and normal cranial computed tomography scan results require hospitalization for neurologic observation ? hospitalizing children with normal ct scans after blunt head trauma is not necessary study suggests alzheimer s disease associated amyloid is rapidly seeded by herpesviridae to protect against brain infection amyloid beta protein protects brain from herpes infection by entrapping viral particles accessible telemedicine diagnostics with elisa in a d printed pipette tip new d printed technology lowers cost of common medical test perceptions of contextual features related to implementation and sustainability of school wide positive behavior support data driven team key to sustaining positive behavior framework in schools access to banking and its value in developed countries evidence from the u.s. marijuana industry economists examined us legal cannabis sector to gauge value of banking services direct d cell printing of human skin with functional transwell system d printing breakthrough heralds new era for advanced skin models actin cytoskeleton remodeling drives breast cancer cell escape from natural killer mediated cytotoxicity actin cytoskeleton remodeling protects tumor cells against immune attack human breast milk and antiretrovirals dramatically reduce oral hiv transmission in blt humanized mice breast milk kills hiv and blocks its oral transmission in humanized mouse early combined immunosuppression may be effective and safe in older patients with crohn s disease post hoc analysis of react older patients with crohn s disease benefit from new medications medusavirus a novel large dna virus discovered from hot spring water new giant virus may help scientists better understand the emergence of complex life developmental exposure to bisphenol a bpa alters sexual differentiation in painted turtles chrysemys picta bpa can disrupt sexual function in turtles could be a warning for environmental health synergy or interference the effect of product placement on commercial break audience decline product placement can curb tv commercial audience loss by more than percent supportive family environments ameliorate the link between racial discrimination and epigenetic aging a replication across two longitudinal cohorts family support buffers the physiological effects of racial discrimination viral etiology of severe pneumonia among kenyan infants and children vaccination key to preventing childhood pneumonia in sub saharan africa beliefs and experimentation with electronic cigarettes a prospective analysis among young adults perceived benefits of electronic cigarettes may lead to higher experimentation rates long range gabaergic inputs regulate neural stem cell quiescence and control adult hippocampal neurogenesis how do adult brain circuits regulate new neuron production ? a novel role for brain interleukin facilitation of cognitive flexibility in rat orbitofrontal cortex low levels of pro inflammatory agent help cognition in rats combining biologic and phototherapy treatments for psoriasis safety efficacy and patient acceptability combining biologic and phototherapy treatments for moderate to severe psoriasis surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells scientists find groovy way to influence specialization of stem cells brain and psychological determinants of placebo pill response in chronic pain patients sugar pills relieve pain for chronic pain patients tau pathology induces excitatory neuron loss grid cell dysfunction and spatial memory deficits reminiscent of early alzheimer s disease in alzheimer s excess tau protein damages brain s gps a population of navigator neurons is essential for olfactory map formation during the critical period navigator neurons play critical role in sense of smell the relationship between vitamin c status the gut liver axis and metabolic syndrome metabolic syndrome patients need more vitamin c to break cycle of antioxidant depletion large recovery of fish biomass in a no take marine reserve hidden baja undersea park is the world s most robust marine reserve lethally hot temperatures during the early triassic greenhouse tropical collapse in early triassic caused by lethal heat extreme temperatures blamed for dead zone research based pam subtype predictor identifies higher responses and improved survival outcomes in her positive breast cancer in the noah study genomic study identifies subgroups of breast cancer with varying sensitivities to treatment high occurrence of jellyfish predation by black browed and campbell albatross identified by dna metabarcoding dna tests on albatross excrement reveal secret diet of top predator protein based human ips cells efficiently generate functional dopamine neurons and can treat a rat model of parkinson disease stem cells reverse disease in a model of parkinson s disease hoxa promotes ovarian cancer growth by stimulating cancer associated fibroblasts ovarian cancer cells hijack surrounding tissues to enhance tumor growth revealing hidden spin momentum locking in a high temperature cuprate superconductor revealing hidden spin unlocking new paths toward high temperature superconductors cancer history portends worse acute and long term noncardiac but not cardiac mortality after primary percutaneous coronary intervention for acute st segment elevation myocardial infarction patients with cancer history experiencing severe heart attacks benefit from cardiac treatment impact of the late triassic mass extinction on functional diversity and composition of marine ecosystems life goes on for marine ecosystems after cataclysmic mass extinction clinical grade stem cell derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs researchers rescue photoreceptors prevent blindness in animal models of age related macular degeneration corals fail to recover at a caribbean marine reserve despite ten years of reserve designation new study of glover s reef challenges whether corals will benefit from marine reserves protection phylogeographic patterns in africa and high resolution delineation of genetic clades in the lion panthera leo lions in west and central africa apparently unique thermal evolution of the impact induced cryomagma chamber beneath occator crater on ceres insulating crust kept cryomagma liquid for millions of years on nearby dwarf planet visual impairment and unmet eye care needs among homeless adults in a canadian city percent of homeless people surveyed in toronto report vision problems analysis of central and peripheral vision reaction times in patients with postconcussion visual dysfunction post concussion peripheral vision reaction times substantially impaired long lasting behavioral responses to stress involve a direct interaction of glucocorticoid receptors with erk msk elk signaling new research might help people suffering from post traumatic stress disorder p rx purinoceptor a therapeutic target for ameliorating the symptoms of duchenne muscular dystrophy mouse model of duchenne muscular dystropy identifies potential new approaches to therapy recent trends in satellite vegetation index observations indicate decreasing vegetation biomass in the southeastern saline everglades wetlands as sea level rises everglades freshwater plants perish mid infrared imaging in breast cancer tissue an objective measure of grading breast cancer biopsies digistain technology offers revolution in detailed cancer diagnosis a prospective study of pre trauma risk factors for post traumatic stress disorder and depression early screening spots emergency workers at greater risk of mental illness cannabis for the management of pain assessment of safety study compass multicenter study examines safety of medical cannabis in treatment of chronic pain genetic recovery of erbb in adulthood partially restores brain functions in null mice researchers alleviate schizophrenia symptoms in new mouse models mobilizing millennial voters with targeted internet advertisements a field experiment first study to find digital ads work on millennials running induced systemic cathepsin b secretion is associated with memory function running releases protein associated with improved memory in mice recent extinctions disturb path to equilibrium diversity in caribbean bats caribbean bats need million years to recover from recent extinction waves pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice powerful food derived antioxidant can halt prevent fatty liver disease in mice epithelial il ra mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen protein controlling gut s protective force field identified immune system receptor encourages growth of bacterial shield during illness arginine plus proline supplementation elicits metabolic adaptation that favors wound healing in diabetic rats arginine and proline enriched diet may speed wound healing in diabetes global and local impacts of delayed mercury mitigation efforts impact of mercury controlling policies shrinks with every five year delay study finds a genuine win win resolving the conserve or catch conflict in marine reserve network design scientists design first reserve network balancing fishing benefits species protection smoking cessation treatment and risk of depression suicide and self harm in the clinical practice research datalink prospective cohort study no increased risk of suicide in patients using smoking cessation drugs identifying a breeding habitat of a critically endangered fish acheilognathus typus in a natural river in japan using edna to identify the breeding habitat of endangered species passive acoustic tracking of singing humpback whales megaptera novaeangliae on a northwest atlantic feeding ground singing humpback whales tracked on northwest atlantic feeding ground highly resolved early eocene food webs show development of modern trophic structure after the end cretaceous extinction ancient food webs developed modern structure soon after mass extinction alcohol harm reduction corporate capture of a key concept call to change concept of harm reduction in alcohol policy determinants of social outcomes in adults with childhood onset epilepsy even seizure free children with epilepsy can face social problems as adults first alma light curve constrains refreshed reverse shocks jets magnetization in grb b enduring radio rebound powered by jets from gamma ray burst on demand erythrocyte disposal and iron recycling requires transient macrophages in the liver how the body disposes of red blood cells recycles iron nottingham prognostic index plus npi a modern clinical decision making tool in breast cancer new prognostic test for breast cancer could improve patient treatment evaluating the effects of pioneer accountable care organizations on medicare part d drug spending and utilization accountable care organizations reduced medical costs without increasing drug costs decreased brain connectivity in smoking contrasts with increased connectivity in drinking different brain areas linked to smoking and drinking genetic coregulation of age of female sexual maturation and lifespan through circulating igf among inbred mouse strains delayed female sexual maturity linked to longer lifespan in mice incidence of sexually transmitted hepatitis c virus infection in hiv positive msm upward trend in hepatitis c infection rates among hiv positive msm divergent sapovirus strains and infection prevalence in wild carnivores in the serengeti ecosystem a long term study long term monitoring of sapovirus infection in wild carnivores in the serengeti phantom mobility based prosthesis control in transhumeral amputees without surgical reinnervation a preliminary study a prosthetic arm that decodes phantom limb movements montessori public school pre k programs and the school readiness of low income black and latino children. low income latino children show benefits from montessori pre kindergartern programs study finds prenatal stress increases the obesogenic effects of a high fat sucrose diet in adult rats in a sex specific manner stress during gestation causes a predisposition to the development of pathologies in adulthood slowdown of the walker circulation at solar cycle maximum winds of change solar variability weakens the walker cell assessing state stem cell programs in the united states how has state funding affected publication trends ? state funding boosts stem cell research in california other states understanding misunderstandings in invasion science why experts don t agree on common concepts and risk assessments are invasive plants a problem in europe ? controversial views among invasion biologists probiotics prevent ige associated allergy until age years in cesarean delivered children but not in the total cohort probiotics may prevent certain allergies in cesarean delivered children but not in all children a new class of low surface energy anionic surfactant for enhanced oil recovery eor a new class of branched single chain surfactant for enhanced oil recovery reported physical fitness and aortic stiffness explain the reduced cognitive performance associated with increasing age in older people better physical fitness and lower aortic stiffness key to slower brain aging sociodemographic predictors of exclusive breast feeding among low income women attending a special supplemental nutrition program for women infants and children wic programme high rates of formula use with low income infants and week outcomes for the child adolescent anxiety multimodal study cams effective treatment for youth anxiety disorders has lasting benefit population genomic analyses reveal a highly differentiated and endangered genetic cluster of northern goshawks accipiter gentilis laingi in haida gwaii genomic study finds haida gwaii s northern goshawks are highly distinct and at risk dna methylation at stress related genes is associated with exposure to early life institutionalization social adversity early in life may affect the expression of stress related genes reasons for energy drink use and reported adverse effects among adolescent emergency department patients energy drink use in teens has adverse effects emergency management of febrile status epilepticus results of the febstat study early treatment with aed reduces duration of febrile seizures predictive factors for short and long term hearing preservation in cochlear implantation with conventional length electrodes best practices for cochlear implant hearing preservation identified the smarttarget biopsy trial a prospective within person randomised blinded trial comparing the accuracy of visual registration and magnetic resonance imaging ultrasound image fusion targeted biopsies for prostate cancer risk stratification revolutionary technology pinpoints biopsies to detect prostate cancer targeted delivery of crispr cas ribonucleoprotein into arthropod ovaries for heritable germline gene editing new technology improves crispr cas gene editing in mosquitoes other species two billion years of magmatism recorded from a single mars meteorite ejection site evidence of billion years of volcanic activity on mars diamond nanogel embedded contact lenses mediate lysozyme dependent therapeutic release nanodiamond embedded contact lenses may improve glaucoma treatment bdnf val met variant and adolescent stress interact to promote susceptibility to anorexic behavior in mice anorexia like condition in mice triggered by combination of genetic risk stress dieting as safe as possible asap a brief app supported inpatient intervention to prevent postdischarge suicidal behavior in hospitalized suicidal adolescents app brief intervention may be lifesaver for suicidal teens chronic carbon monoxide inhalation during pregnancy augments uterine artery blood flow and uteroplacental vascular growth in mice carbon monoxide could hold promise of effective preeclampsia treatment prevention human induced pluripotent stem cell derived mge cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration stem cell derived neurons stop seizures and improve cognitive function assessment of guideline discordance with antimicrobial prophylaxis best practices for common urologic procedures antibiotic overuse is high for common urology procedures progression marker of parkinson s disease a year multi site imaging study waterlogged brain region helps scientists gauge damage caused by parkinson s disease many uk patients with gonorrhoea are given outdated antibiotics many uk patients with gonorrhea prescribed outdated antibiotics multisite thrombus imaging and fibrin content estimation with a single whole body pet scan in rats whole body pet scan with new imaging agent can locate hidden blood clots drug induced acute liver failure results of a u.s. multicenter prospective study anti microbials are a common cause of drug induced liver injury and failure study suggests diversity outbred mice identify population based exposure thresholds and genetic factors that influence benzene induced genotoxicity diversity outbred mice better predict potential human responses to chemical exposures zinc finger protein regulates imprinted expression of transcripts in prader willi syndrome neurons prader willi syndrome reversed in brain cells growing in the lab systemic delivery of factor ix messenger rna for protein replacement therapy success of new protein making therapy for hemophilia more impact assessment of pollution in some lake water located at and around thane city of maharashtra india physico chemical properties and toxic effects of heavy metal content heavy metal in and around the lakes pollution due to toxic heavy metals at the jail talav and kalwa lakes of thane city frequent physical activity may not reduce vascular disease risk as much as moderate activity large prospective study of uk women women active a few times weekly have lower risk of heart disease stroke and blood clots procedural success and adverse events in pulmonary artery stenting stenting of narrow pulmonary artery benefits patients with congenital heart disease focusing of long waves with finite crest over constant depth sea floor earthquake zones can act like a magnifying lens strengthening tsunamis beyond what was through possible key team physical and technical performance indicators indicative of team quality in the soccer chinese super league crucial ingredients for a winning soccer team kick goals electronic cigarette use and smoking initiation among youth a longitudinal cohort study e cigarette use by high school students linked to cigarette smoking elevated inflammatory biomarkers during unemployment modification by age and country in the uk stress markers in unemployed linked to poor health cs a prodrug of the new neuraminidase inhibitor r shows long acting anti influenza virus activity new na inhibitor offers long lasting protection against influenza virus evaluating the impacts of protected areas on human well being across the developing world living near protected areas can have positive impacts on human well being sex and race differences in the association between statin use and the incidence of alzheimer disease cholesterol fighting drugs lower risk of alzheimer s disease benchmark experiment for photoionized plasma emission from accretion powered x ray sources black hole models contradicted by hands on tests sea level projections to ad with a new generation of climate change scenarios sea levels to continue to rise for years ? long term climate calculations suggest so upregulation of sox inhibits the growth of human and mouse melanomas and restores their sensitivity to retinoic acid transcriptional factor sox renders melanomas sensitive to retinoic acid and stops tumor growth cannabis legislation fails to protect canada s youth legalizing marijuana will harm health of youth in canada study shows loss of an androgen inactivating and isoform specific hsd b splice form enables emergence of castration resistant prostate cancer new gene variant linked to deadly prostate cancer using pittsburgh compound b for pet imaging across the alzheimer s disease spectrum pet imaging with special tracer can detect diagnose early alzheimer s disease relic dna is abundant in soil and obscures estimates of soil microbial diversity scientists zero in on biological diversity in poor man s rainforest social support and actual versus expected length of stay in inpatient rehabilitation facilities strong social support is related to shorter stay in inpatient rehab after hospitalization chimeric c r anti cd antibody therapy is critical for long term survival of gtko.hcd.htbm pig to primate cardiac xenograft much longer survival for heart transplants across species long term deficits in cortical circuit function after asphyxial cardiac arrest and resuscitation in developing rats long term brain deficits in cardiac arrest survivors treatment ? silent memory engrams as the basis for retrograde amnesia neuroscientists build case for new theory of memory formation a drosophila model identifies a critical role for zinc in mineralization for kidney stone disease zinc in the body may contribute to kidney stones ten year follow up after initiation of statin therapy in children with familial hypercholesterolemia benefit of statin therapy for children with inherited cholesterol disorder shown by long term study is the incidence of rheumatoid arthritis rising ? results from olmsted county minnesota rheumatoid arthritis incidence on the rise in women lactobacillus plantarum attenuates anxiety related behavior and protects against stress induced dysbiosis in adult zebrafish common probiotics can reduce stress levels lessen anxiety social deficits in shank deficient mouse models of autism are rescued by histone deacetylase hdac inhibition autism s social deficits are reversed by an anti cancer drug deep sequencing of plant and animal dna contained within traditional chinese medicines reveals legality issues and health safety concerns deep sequencing reveals potentially toxic trade restricted ingredients in some traditional chinese medicines mapping changes in housing in sub saharan africa from to dramatic housing transformation in sub saharan africa revealed for first time theta burst microstimulation in the human entorhinal area improves memory specificity neuroscientists improve human memory by electrically stimulating brain discovery of blood transcriptomic markers for depression in animal models and pilot validation in subjects with early onset major depression first blood test to diagnose major depression in teens physical activity benefits the skeleton of children genetically predisposed to lower bone density in adulthood physical activity builds stronger bones even in children with genetic risk building buzz scientists communicating science in new media environments greater use of social media gets science scientists noticed study says hiv aids using hiv sequence and epidemiologic data to assess the effect of self referral testing for acute hiv infection on incident diagnoses in san diego california hiv testing during early infection may reduce new cases in high risk communities dengue outlook for the world cup in brazil an early warning model framework driven by real time seasonal climate forecasts new early warning system predicts dengue fever risk during the football world cup in brazil nuclear receptor subfamily group d member regulates circadian activity of nlrp inflammasome to reduce the severity of fulminant hepatitis in mice could the biological clock be a key ally in the fight against inflammatory disease ? inhibition of hiv integration in ex vivo infected cd t cells from elite controllers elite controllers block integration of hiv dna into host genome trimethylamine n oxide tmao response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition a randomized controlled trial dietary compound linked to heart disease may be influenced by gut microbiome identification of genes required for eye development by high throughput screening of mouse knockouts blind mice uncover genetic causes of eye disease health related quality of life and hemoglobin levels in chronic kidney disease preventing anemia is important to kidney disease patients quality of life population screening for variant creutzfeldt jakob disease using a novel blood test blood test to screen for fatal variant creutzfeldt jakob disease latest evidence on using hormone replacement therapy in the menopause latest evidence on using hormone replacement therapy for treating menopausal symptoms the toxic effects of cigarette additives. philip morris project mix reconsidered an analysis of documents released through litigation tobacco company misrepresented danger from cigarettes study suggests chronological characterization of medieval villages in northern iberia a multi integrated approach statistical method recreates the history of a long abandoned village low dose thyroxine attenuates autism associated adverse effects of fetal alcohol in male offspring s social behavior and hippocampal gene expression could novel drug target autism and fetal alcohol disorder ? the c. elegans touch response facilitates escape from predacious fungi elusive prey selection pressures imposed by predator fungi have shaped escape behavior in microscopic worms movement of feeder using songbirds the influence of urban features roads urban features influence their choice of gardens electronic tracking of song birds shows cellular treatments for spinal cord injury the time is right for clinical trials timing for clinical trials for stem cell therapy in spinal cord injuries is right review suggests hormonal contraception and risk of thromboembolism in women with diabetes hormonal contraception is safer than expected for women with diabetes effect of depth of sedation in older patients undergoing hip fracture repair on postoperative delirium lighter sedation won t drop risk of postop delirium conformational risk factors of brachycephalic obstructive airway syndrome boas in pugs french bulldogs and bulldogs no simple way of predicting breathing difficulties in pugs french bulldogs and bulldogs from external features effects of weight loss on airway responsiveness in obese adults with asthma weight loss in obese adults can reduce severity of asthma how uneven are changes to impact relevant climate hazards in a. c world and beyond ? who shares similar experiences of climate change in a. c world and beyond ? long term analysis of oncologic outcomes after laparoscopic radical cystectomy in europe results from a multicentric study of eau section of uro technology laparoscopic surgery for bladder cancer leads to good long term cancer control anticollagen type ii antibodies are associated with an acute onset rheumatoid arthritis phenotype and prognosticate lower degree of inflammation during years follow up new tool for prognosis choice of therapy for rheumatoid arthritis group intervention for individuals with primary progressive aphasia and their spouses who comes first ? new hope for patients with primary progressive aphasia relative in vitro wood decay resistance of sapwood from landscape trees of southern temperate regions landscape tree disease from wood decay fungi studied systematic evaluation of pleiotropy identifies further loci associated with coronary artery disease genome studies point to common disease mechanisms in cardiovascular and other diseases deep genetic structure and ecological divergence in a widespread human commensal toad study of asian common toad reveals three divergent groups in utero exposure to adrenergic receptor agonist drugs and risk for autism spectrum disorders anti asthma drugs taken during pregnancy associated with autism risk tooth oxygen isotopes reveal late bronze age origin of mediterranean fish aquaculture and trade extensive trade in fish between egypt and canaan years ago the socioecology of sexual and reproductive health care use among young urban minority males barriers to sexual health among male teens and young men associations among musculoskeletal impairments depression body image and fatigue in breast cancer survivors within the first year after treatment depression and pain increase fatigue in breast cancer survivors triple therapy versus biologic therapy for active rheumatoid arthritis biologics before triple therapy not cost effective for rheumatoid arthritis brain imaging changes associated with risk factors for cardiovascular and cerebrovascular disease in asymptomatic patients new window of opportunity to prevent cardiovascular diseases methylation qtls in the developing brain and their enrichment in schizophrenia risk loci schizophrenia associated genetic variants affect gene regulation in the developing brain sun protection at elementary schools a cluster randomized trial sun protection program increases hat use among th graders mind wandering as spontaneous thought a dynamic framework understanding mind wandering could shed light on mental illness discordant perceptions of prognosis and treatment options between physicians and patients with advanced heart failure heart failure patients clinicians have differing perceptions of risk level climate and ground temperature relations at sites across the continuous and discontinuous permafrost zones northern canada northern canada feels the heat climate change impact on permafrost zones the impact of reading intervention on brain responses underlying language in children with autism autistic children improved reading brain activity after week reading intervention the genetic history of admixture across inner eurasia details of the history of inner eurasia revealed advancing methods of assessing bone quality to expand screening for osteoporosis ultrasound can assess bone health increase early screening for osteoporosis long term safety and activity of axicabtagene ciloleucel in refractory large b cell lymphoma zuma a single arm multicentre phase trial new two year data show percent of non hodgkin lymphoma patients treated with car t cell therapy remain in remission higher testosterone levels are associated with less loss of lean body mass in older men older men with higher testosterone levels lose less muscle mass as they age beneficial effects of increased lysozyme levels in alzheimer s disease modelled indrosophila melanogaster new treatment strategy against alzheimer s disease ? transmission routes maintaining a viral pathogen of steelhead trout within a complex multi host assemblage tracking the spread of a deadly fish virus in the pacific northwest discrete mechanisms of mtor and cell cycle regulation by ampk agonists independent of ampk study questions anti cancer mechanisms of drug tested in clinical trials the tongue enables computer and wheelchair control for people with spinal cord injury tongue controlled wheelchair outperforms popular wheelchair navigation system climate change vulnerability for species assessing the assessments historical wildlife trends reliable for predicting species at risk mre deficiency increases sensitivity to poly adp ribose polymerase inhibition in microsatellite unstable colorectal cancers new class of cancer drugs could work in colon cancers with genetic mutation study finds chronoprints identifying samples by visualizing how they change over space and time chronoprints identify samples by how they change over space and time born at the right time ? a conceptual framework linking reproduction development and settlement in reef fish born under an inauspicious moon baby fish delay settlement on coral reefs television exposure as a risk factor for aggressive behavior among year old children tv exposure may be associated with aggressive behavior in young children a gene duplication affecting expression of the ovine asip gene is responsible for white and black sheep scientists identify genetic basis for the black sheep of the family improving affordability through innovation in the surgical treatment of mitral valve disease hospital cost of robotic or conventional open chest mitral valve repair surgery is similar mostly the mother concentration of adverse employment effects on mothers of children with autism mothers of children with autism pay price in workplace pdgfr positive cells in bone marrow are mobilized by high mobility group box hmgb to regenerate injured epithelia bone marrow cells that transform into skin cells could revolutionize approach to wound treatment north atlantic natural variability modulates emergence of widespread greenland melt in a warming climate natural climate oscillations in north atlantic linked to greenland ice sheet melt effectiveness of protective eyewear in reducing eye injuries among high school field hockey players protective eyewear reduces eye head and facial injuries field hockey study shows seasonal water storage stress modulation and california seismicity seasonal rain and snow trigger small earthquakes on california faults mutations in bckd kinase lead to a potentially treatable form of autism with epilepsy nutritional supplement offers promise in treatment of unique form of autism an inhibitor of the protein kinases tbk and ikk improves obesity related metabolic dysfunctions in mice old drug may point the way to new treatments for diabetes and obesity heterogeneous retreat and ice melt of thwaites glacier west antarctica huge cavity in antarctic glacier signals rapid decay geographic variation and trends in opioid involved crash deaths in maryland fatal opioid related car crashes in maryland hold steady over decade pre existing immunity against swine origin h n influenza viruses in the general human population previous seasonal flu infections may provide some level of h n immunity resveratrol levels and all cause mortality in older community dwelling adults diets rich in antioxidant resveratrol fail to reduce deaths heart disease or cancer development of a c stable isotope assay for dipeptidyl peptidase enzyme activity a new breath test for dipeptidyl peptidase activity baby step towards breath testing for gut disorders son connects the splicing regulatory network with pluripotency in human embryonic stem cells singapore scientists discover new rna processing pathway important in human embryonic stem cells explicit performance in girls and implicit processing in boys a simultaneous fnirs erp study on second language syntactic learning in young adolescents different neural strategies for junior high school male and female english learners defective b cell tolerance in adenosine deaminase deficiency is corrected by gene therapy gene therapy can correct forms of severe combined immunodeficiency study suggests neutralizing human monoclonal antibodies prevent zika virus infection in macaques monoclonal antibody cocktail halts zika infection according to new study patterns of fetal and infant growth are related to atopy and wheezing disorders at age years allergies and wheezing illnesses in childhood may be determined in the womb antiaging treatment of the facial skin by fat graft and adipose derived stem cells two different fat graft techniques have similar effects on facial skin dimethyl sulfoxide and quercetin prolong the survival motility and fertility of cold stored mouse sperm for days refrigeration technology to maintain cold stored mouse sperm viability for days an evidence based unified definition of lifelong and acquired premature ejaculation report of the second international society for sexual medicine ad hoc committee for the definition of premature ejaculation new insights into premature ejaculation could lead to better diagnosis treatment acrolein is a pathogenic mediator of alcoholic liver disease and the scavenger hydralazine is protective in mice stem cell transplant from young to old can heal stomach ulcers selecting growth measures for use in school evaluation systems should proportionality matter ? evaluations that consider school resources could fairly assess teacher performance a serpin shapes the extracellular environment to prevent influenza a virus maturation key to blocking influenza virus may lie in a cell s own machinery flapping before flight high resolution three dimensional skeletal kinematics of wings and legs during avian development leg wing cooperation in baby birds dinosaurs is key transition in origin of flight bats without borders predators learn novel prey cues from other predatory species predators learn to identify prey from other species genome wide association study of alcohol dependence implicates a region on chromosome genome wide study of alcohol dependence points to chromosome fear responses to noises in domestic dogs prevalence risk factors and co occurrence with other fear related behaviour new insight into dogs fear responses to noise longitudinal analysis indicates symptom severity influences immune profile in irritable bowel syndrome exhausted immune cells linked to irritable bowel syndrome receptor mimicry by antibody f facilitates universal binding to the h subtype of influenza virus study may help slow the spread of flu neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in alzheimer s disease mouse models new alzheimer s therapy with brain blood flow discovery ? tree ring based drought reconstruction in the iberian range east of spain since radiography of drought periods in spain from the last years murine colitis reveals a disease associated bacteriophage community intestinal virus study shows major changes associated with inflammatory bowel disease rna viruses can hijack vertebrate micrornas to suppress innate immunity immune avoidance mechanism could lead to treatments for deadly mosquito borne viruses marketing foods to children a comparison of nutrient content between children s and non children s products children s healthy foods marketed at children are higher in fat sugar and salt apolipoprotein e is associated with improved cognitive function in amazonian forager horticulturalists with a high parasite burden dementia gene may guard against decline associated with parasitic disease measuring the solar potential of a city and its implications for energy policy suburban sprawl to power cities of the future ancient genomes document multiple waves of migration in southeast asian prehistory scientists analyze first ancient human dna from southeast asia molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia a report from the cognitive genomics consortium cogent researchers show genetic overlap in schizophrenia cognitive ability identification of cpg snps associated with type diabetes and differential dna methylation in human pancreatic islets new clues in hunt for heredity in type diabetes rare genetic variation at zea mays crtrb increases carotene in maize grain orange corn holds promise for reducing blindness child death altrichthys alelia a new brooding damselfish teleostei perciformes pomacentridae from busuanga island philippines new coral reef fish species shows rare parental care behavior the jobs act and ipo volume evidence that disclosure costs affect the ipo decision public startups boom under jobs act study shows distinct extended amygdala circuits for divergent motivational states how two brain areas interact to trigger divergent emotional behaviors association of maternal anemia with increased wheeze and asthma in children pregnancy anemia linked to childhood wheezing and asthma normalization of blood pressure with spinal cord epidural stimulation after severe spinal cord injury epidural stimulation shown to normalize blood pressure following spinal cord injury cerebral white matter structure is disrupted in gulf war veterans with chronic musculoskeletal pain white matter damage linked to chronic musculoskeletal pain in gulf war veterans geographic factors and human papillomavirus hpv vaccination initiation among adolescent girls in the united states hpv vaccine uptake is highest among girls in high poverty majority hispanic communities a novel anxiety and affective spectrum disorder of mind and body the alpim anxiety laxity pain immune mood syndrome a preliminary report researchers identify new spectrum disorder called alpim syndrome predation drives recurrent convergence of an interspecies mutualism predators drive nemo s relationship with an unlikely friend therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres lung fibrosis cured in mice with a gene therapy that lengthens telomeres monocentric cyberspace the primary market for internet domain names internet domain space overcrowded and stifling demand suggesting a future not com boom sex differences in the cardiovascular consequences of diabetes mellitus a scientific statement from the american heart association sex differences in type diabetes affect cardiovascular disease risk synergistic immuno photothermal nanotherapy symphony for the treatment of unresectable and metastatic cancers gold nanostars and immunotherapy vaccinate mice against cancer podocalyxin is required for maintaining blood brain barrier function during acute inflammation how blood vessels protect the brain during inflammation enso drove year collapse of eastern pacific coral reefs natural climate shifts drove coral reefs to a total ecosystem collapse lasting years contraceptive method choice among young adults influence of individual and relationship factors relationship factors affect decisions about contraceptive use among young adults brite constellation high precision time dependent photometry of the early o type supergiant puppis unveils the photospheric drivers of its small and large scale wind structures spots on supergiant star drive spirals in stellar wind effect of low dose ferrous sulfate vs iron polysaccharide complex on hemoglobin concentration in young children with nutritional iron deficiency anemia a randomized clinical trial traditional treatment is better for iron deficiency anemia clinical trial shows defective cholesterol clearance limits remyelination in the aged central nervous system multiple sclerosis cholesterol crystals prevent regeneration in central nervous system lead pollution recorded in greenland ice indicates european emissions tracked plagues wars and imperial expansion during antiquity lead pollution in greenland ice shows rise and fall of ancient european civilizations topiramate use early in pregnancy and the risk of oral clefts topiramate in early pregnancy increases risk of oral clefts maternal alcohol use disorder and risk of child contact with the justice system in western australia a population cohort record linkage study heavy drinking mothers linked to their child s path toward the justice system opioid prescribing decreases after learning of a patient s fatal overdose doctors reduced opioid prescriptions after learning a patient overdosed golden opportunity multidisciplinary simulation training improves trauma team efficiency simulation training saves precious minutes in speeding treatment of trauma patients decade of change in enhalus acoroides seagrass meadows in guam mariana islands seagrass meadows in guam have decreased by percent new analysis shows nasogastric or nasointestinal feeding in severe acute pancreatitis new options for enteral nutrition in patients with severe acute pancreatitis the persistent effects of minimum legal drinking age laws on drinking patterns later in life lower drinking ages lead to more binge drinking study of u.s. states finds a coxsackievirus b vaccine protects against virus induced diabetes in an experimental mouse model of type diabetes enterovirus vaccine prevents virus induced diabetes in a t d experimental model why won t they participate ? barriers to participation in worksite health promotion programmes worksite health promotion programs why don t people participate ? a time and cost effective strategy to sequence mammalian y chromosomes an application to the de novo assembly of gorilla y new method reveals high similarity between gorilla and human y chromosome effect of wuchereria bancrofti infection on hiv incidence in southwest tanzania a prospective cohort study infections with the parasitic worm w bancrofti associated with increased risk of hiv infection according to tanzanian study long term follow up on recovery return to use and sporting activity a retrospective study of operated colic horses in finland positive long term colic surgery results for horses is adaptation to climate change really constrained in niche specialists ? evolution in rainforest flies points to climate change survival human serum derived protein removes the need for coating in defined human pluripotent stem cell culture breakthrough in scaling up life changing stem cell production concussions traumatic brain injury and the innovative use of omega s concussions and brain injury can omega intake aid in brain health recovery ? brief motivational intervention for intimate partner violence and heavy drinking in the emergency department emergency department counseling program fails to reduce intimate partner violence or heavy drinking among at risk women oncolysis of canine tumor cells by myxoma virus lacking the serp gene scientists aim to put a pox on dog cancer association between borderline neonatal thyroid stimulating hormone concentrations and educational and developmental outcomes a population based record linkage study newborns with borderline thyroid function at higher risk of poor neurodevelopmental outcomes state of stress in the permian basin texas and new mexico implications for induced seismicity new map profiles induced earthquake risk for west texas an elusive neotropical giant hondurantemna chespiritoi gen. n. sp. n. antemninae mantidae a new lineage of mantises exhibiting an ontogenetic change in cryptic strategy gender dictates camouflage strategy in this newly identified praying mantis group seasonal variation in blood drug concentrations and a potential relationship to vitamin d sunlight can influence the breakdown of medicines in the body historical earthquakes of the eastern sunda arc source mechanisms and intensity based testing of indonesia s national seismic hazard assessment historic earthquakes test indonesia s seismic hazard assessment plant based no added fat or american heart association diets impact on cardiovascular risk in obese children with hypercholesterolemia and their parents plant based diet may reduce obese children s risk of heart disease in vivo jnk activation in pancreatic cells leads to glucose intolerance caused by insulin resistance in pancreas new advances in the molecular study of diabetes interaction between invasive plant leaf litter and nacl on two model amphibians invasive species in an ecosystem harm native organisms but aid other invasive species conservation genomics of the declining north american bumblebee bombus terricola reveals inbreeding and selection on immune genes inbreeding and disease are factors in decline of yellow banded bumblebee evidence for charge transfer mediation in the primary events of singlet fission in a weakly coupled pentacene dimer a milestone on the path towards efficient solar cells singlet fission autoimmune antibodies and recurrence free interval in melanoma patients treated with adjuvant interferon lack of association between autoimmune antibodies and improved outcome in melanoma patients changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiologic stress prolonged military style training causes changes to intestinal bacteria increases inflammation boundary condition controls on the high sand flux regions of mars on mars sands shift to a different drum of mice and worms are co infections with unrelated parasite strains more damaging to definitive hosts ? parasite infections with multiple strains are more harmful to vertebrate hosts strong disk winds traced throughout outbursts in black hole x ray binaries first evidence of winds outside black holes throughout their mealtimes predicting bycatch hotspots for endangered leatherback turtles on longlines in the pacific ocean critically endangered leatherback turtles tracked to reveal danger zones from industrial fishing childhood trauma is associated with severity of hallucinations and delusions in psychotic disorders a systematic review and meta analysis childhood trauma link offers treatment hope for people with schizophrenia global shark currency the distribution frequency and economic value of shark ecotourism conservation dollars and sense a case for shark conservation through ecotourism parent conversations about healthful eating and weightassociations with adolescent disordered eating behaviorsparent conversations about eating and weight conversations with teens about weight linked with increased risk of unhealthy eating behaviors congenital nystagmus gene frmd is necessary for establishing a neuronal circuit asymmetry for direction selectivity defect in retinal computation linked to congenital nystagmus risk of narcolepsy in children and young people receiving as adjuvanted pandemic a h n influenza vaccine retrospective analysis increased risk of sleep disorder narcolepsy in children who received swine flu vaccine a precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors targeting the engine room of the cancer cell examining rural urban differences in prescription opioid misuse among us adolescents adolescent painkiller abuse a big problem for small towns rural areas role of vta dopamine neurons and neuroligin in sociability traits related to nonfamiliar conspecific interaction synapses of the reward system at stake in autistic disorders parallel epigenomic and transcriptomic responses to viral infection in honey bees apis mellifera honey bees use multiple genetic pathways to fight infections beneficial effects of low alcohol exposure but adverse effects of high alcohol intake on glymphatic function low levels of alcohol good for the brain study shows the effect of medical marijuana laws on the health and labor supply of older adults evidence from the health and retirement study medical marijuana laws linked to health and labor supply benefits in older adults brain breaks physical activity in the classroom for elementary school children brain breaks increase activity educational performance in elementary schools combining paleo data and modern exclosure experiments to assess the impact of megafauna extinctions on woody vegetation extinction of pleistocene herbivores induced major vegetation and landscape changes some worms like it hot fish parasites grow faster in warmer water and alter host thermal preferences global warming changes balance between parasite and host in fish comparing pre and post copulatory mate competition using social network analysis in wild crickets promiscuity could reduce benefits of successful mating research shows the aca s pediatric essential health benefit has resulted in a state by state patchwork of coverage with exclusions us affordable care act leaves many children without important benefits sub classification based specific movement control exercises are superior to general exercise in sub acute low back pain when both are combined with manual therapy a randomized controlled trial personalized physical therapy brings relief for lower back pain accelerating glacier mass loss on franz josef land russian arctic russian arctic glacier loss doubles as temps warm amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes more patients with lou gehrig s disease have genetic origin than previously thought genome wide association analyses identify new susceptibility loci for generalized vitiligo eye color may indicate risk for serious skin conditions the domestication syndrome in mammals a unified explanation based on neural crest cell behavior and genetics domestication syndrome white patches baby faces and tameness explained by mild neural crest deficits mtorc stimulates phosphatidylcholine synthesis to promote triglyceride secretion insulin signaling molecule in liver controls levels of triglyceride in blood a trans european union difference in the decline in trans fatty acids in popular foods a market basket investigation millions of europeans still at risk from high trans fatty acid content in popular foods n methyldecahydroquinolines an unexpected class of alkaloids from amazonian poison frogs dendrobatidae newly discovered chemical weapon in poison frogs arsenal children born by women with rheumatoid arthritis have increased susceptibility for selected chronic diseases a nationwide cohort study rheumatoid arthritis during pregnancy may increase chronic disease risk in children diplomats mystery illness and pulsed radiofrequency microwave radiation diplomats mystery illness linked to radiofrequency microwave radiation researcher says evaluating the effectiveness of child safety seats and seat belts in protecting children from injury child safety seats and lap and shoulder belts effective in preventing serious injury study suggests synchronization of speed sound and iridescent color in a hummingbird aerial courtship dive dive bombing for love male hummingbirds dazzle females with a highly synchronized display two new phragmotic ant species from africa morphology and next generation sequencing solve a caste association problem in the genus carebara westwood saucer like shields protect two new door head ant species from africa and their nests pharmacological inhibition of myocardin related transcription factor pathway blocks lung metastases of rhoc overexpressing melanoma promising new drug stops spread of melanoma by percent evolutionary history of human colitis associated colorectal cancer uncovering the evolutionary history of ibd associated colorectal cancer effects of motivation and medication on electrophysiological markers of response inhibition in children with attention deficit hyperactivity disorder behavioral incentives mimic effects of medication on brain systems in adhd impact of institutional volume on outcomes of catheter directed thrombolysis in the treatment of acute proximal deep vein thrombosis a year united states experience research analyzes impact of case volume on outcomes for dvt treatment promoterless gene targeting without nucleases ameliorates haemophilia b in mice new way of genome editing cures hemophilia in mice may be safer than older method infection control preparedness for human infection with in. hexdec fb. uenza a h n in hong kong infection control preparedness measures control avian flu in hong kong hospital metagenomic analysis with strain level resolution reveals fine scale variation in the human pregnancy microbiome characterization of pregnancy microbiome reveals variations in bacterial diversity family provided health care for children with special health care needs national study documents value of family provided medical care for children public attitudes toward child undervaccination a randomized experiment on evaluations stigmatizing orientations and support for policies parents reasons for not vaccinating children influence public attitudes toward them red fluorescence increases with depth in reef fishes supporting a visual function not uv protection glowing red in the big blue red fluorescence at great depths in vivo evidence for nicotinic acetylcholine receptor subunit upregulation in smokers as compared with nonsmokers with schizophrenia smoking schizophrenia linked by alterations in brain nicotine signals activin type ii receptor signaling in cardiac aging and heart failure new insights into the role of aging in heart failure stress as a seizure precipitant identification associated factors and treatment options stress a common seizure trigger in epilepsy study affirms television viewing and hostile personality trait increase the risk of injuries television viewing linked to higher injury risk in hostile people in vivo laser mediated retinal ganglion cell optoporation using kv. conjugated gold nanoparticles light scalpel a major step toward non viral ocular gene therapy using laser and nanotechnology application of pediatric and adult guidelines for treatment of lipid levels among us adolescents transitioning to young adulthood using pediatric cholesterol guidelines for teens young adults would increase statin use maternal diet and aging alter the epigenetic control of a promoter enhancer interaction at the hnf a gene in rat pancreatic islets why poor diet during pregnancy negatively affects offspring s long term health prospective evaluation of the association of nut peanut consumption with total and cause specific mortality peanut consumption associated with decreased total mortality and mortality from cardiovascular diseases tumor necrosis factor induces gsk kinase mediated cross tolerance to endotoxin in macrophages study identifies novel role for a protein that could lead to new treatments for rheumatoid arthritis potential for chemolithoautotrophy among ubiquitous bacteria lineages in the dark ocean up from the depths how bacteria capture carbon in the twilight zone the social norms and beliefs of teenage male electronic cigarette use social norms of electronic cigarette use by teenagers studied recurrence of autism spectrum disorders in full and half siblings and trends over timea population based cohort study recurrence risk for autism spectrum disorders examined for full half siblings impaired respiratory and body temperature control upon acute serotonergic neuron inhibition researchers target switch off serotonin producing neurons in mice new insights may be relevant to sudden infant death syndrome structural studies and protein engineering of inositol phosphate multikinase potential new treatment target identified for melanoma skin cancer genome wide association study identifies gpc as a novel genetic locus protective against sudden cardiac arrest genetic variation linked to possible protection against sudden cardiac arrest electrohydrodynamic ehd printing of molten metal ink for flexible and stretchable conductor with self healing capability metal printing offers low cost way to make flexible stretchable electronics targeted application of human genetic variation can improve red blood cell production from stem cells study uses gene editing to take brakes off lab based red blood cell production spontaneous symmetry breaking in the formation of supramolecular polymers implications for the origin of biological homochirality the helix of dna fame may have arisen with startling ease modeling alveolar soft part sarcomagenesis in the mouse a role for lactate in the tumor microenvironment research on rare cancer exposes possible route to new treatments international variations in primary care physician consultation time a systematic review of countries primary care consultations last less than minutes for half the world s population suicide as a derangement of the self sacrificial aspect of eusociality. is suicide a tragic variant of an evolutionarily adaptive set of behaviors ? spinal dopaminergic projections control the transition to pathological pain plasticity via a d d mediated mechanism brain chemical may offer new clues in treating chronic pain response of the great barrier reef to sea level and environmental changes over the past years rise and fall of the great barrier reef molecular structure of an n terminal phosphorylated amyloid fibril molecular structure of one of alzheimer s stickier culprits research priorities for mental health and psychosocial support in humanitarian settings experts want practical research to improve mental health of people experiencing humanitarian crises local receptors as novel regulators for peripheral clock expression treatment for overactive bladder and irritable bowel syndrome advanced through pioneering research association between efavirenz based compared with nevirapine based antiretroviral regimens and virological failure in hiv infected children hiv infected children less used regimen is more effective for children in low resource settings prevalence of knee pain radiographic osteoarthritis and arthroplasty in retired professional footballers compared with men in the general population a cross sectional study retired professional footballers at higher risk of knee osteoarthritis age adjusted d dimer cutoff levels to rule out pulmonary embolism use of age adjusted d dimer levels to exclude lung blood clots early science with the large millimeter telescope detection of dust emission in multiple images of a normal galaxy at z lensed by a frontier fields cluster astronomers find unexpected dust obscured star formation in distant galaxy methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with adhd adhd medications do not cause genetic damage in children study shows alcohol consumption and mortality in patients with mild alzheimer s disease a prospective cohort study moderate drinking linked to reduced risk of death in early stage alzheimer s disease pnas plus hunter gatherers and other primates as prey predators and competitors of snakes pythons and people take turns as predators and prey hematopoietic reprogramming in vitro informs in vivo identification of hemogenic precursors to definitive hematopoietic stem cells insights into blood stem cells from engineered stem cells integrating a low field open mr scanner with a static proton research beam line proof of concept high contrast imaging for cancer therapy with protons anemia of chronic disease a harmful disorder or an adaptive beneficial response ? anemia of chronic disease an adaptive response ? time trends in brain cancer incidence rates in relation to mobile phone use in england mobile phone use not related to increased brain cancer risk uk study suggests metapopulation tracking juvenile penguins reveals an ecosystem wide ecological trap endangered african penguins are falling into an ecological trap numeracy predicts risk of pre hospital decision delay a retrospective study of acute coronary syndrome survival study clarifies risky decision making during a heart attack effect of a uri related educational intervention in early head start on ed visits educational interventions at early head start led to decline in pediatric emergency visits synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium mechanism discovered for mosaic pattern of cells in nasal cavity patients learning to read their doctors notes the importance of reminders doctors reminders help keep people more engaged in their health care reducing disparities in tobacco retailer density by banning tobacco product sales near schools banning tobacco sales near schools could reduce socioeconomic disparities new study shows deficiency of x linked protein kinase nrk during pregnancy triggers breast tumor in mice a new tumor suppressor gene for breast cancer in mice prevention of ige sensitization to latex in health care workers after reduction of antigen exposures using powder free latex gloves reduces latex allergy rate in health care workers gabaergic neuron specific loss of ube a causes angelman syndrome like eeg abnormalities and enhances seizure susceptibility neuron type specific gene loss linked to angelman syndrome seizures a metabolic function of fgfr tacc gene fusions in cancer gene fusion shifts cell activity into high gear causing some cancer encoding of vicarious reward prediction in anterior cingulate cortex and relationship with trait empathy our brain s response to others good news depends on empathy experiences with policing among people who inject drugs in bangkok thailand a qualitative study police activities in thailand may lead to riskier behaviors in people who inject drugs aberrant brain response after auditory deviance in ptsd compared to trauma controls an eeg study patients with post traumatic stress disorder respond differently to certain sounds research finds effective implementation of health information technologies in u.s. hospitals improved patient outcomes linked to specific health it resources in hospitals delayed intrathecal delivery of rhoa sirna to the contused spinal cord inhibits allodynia preserves white matter and increases serotonergic fiber growth regenerating nerve cells research offers hope in new treatment for spinal cord injuries the complex relation between bullying victimization acceptance and rejection giving special attention to status affection and sex differences pursuit of status and affection drives bullies behavior the uk national minimum wage s impact on productivity higher wages for uk s lowest paid improve productivity long term supplemental one carbon metabolism related vitamin b use in relation to lung cancer risk in the vitamins and lifestyle vital cohort clear link between heavy vitamin b intake and lung cancer biallelic variants in otud b cause an intellectual disability syndrome associated with seizures and dysmorphic features otud b gene mutations cause intellectual and physical disability chinese herbal medicines for people with impaired glucose tolerance or impaired fasting blood glucose chinese herbal medicines for preventing diabetes in high risk people still not enough hard scientific evidence urinary phthalate biomarker concentrations and postmenopausal breast cancer risk large study fails to link phthalates and increased breast cancer risk land degradation assessment using residual trend analysis of gimms ndvi g soil moisture and rainfall in sub saharan west africa from to space technology identifies vulnerable regions in west africa deregulation of sting signaling in colorectal carcinoma constrains dna damage responses and correlates with tumorigenesis role of sting protein in development of colorectal cancer severity of acute infectious mononucleosis correlates with cross reactive influenza cd t cell receptor repertoires researchers connect severity of kissing disease to t cell population amiodarone anticoagulation and clinical events in patients with atrial fibrillation safer drug combination found for patients with high risk atrial fibrillation in vivo placental mri shape and textural features predict fetal growth restriction and postnatal outcome d mri predicts pregnancies complicated by fetal growth restriction identification of chromatin remodeling genes arid a and arid b as leukemia suppressor genes deletion of chromatin remodeling genes leads to leukemia in mice evaluation of the potential impact of ebola virus genomic drift on the efficacy of sequence based candidate therapeutics genetic changes in ebola virus in west african outbreak could hinder potential treatments behavioral responses of australian fur seals to boat approaches at a breeding colony australian study into how seals react to boats prompts new ecotourism regulations emission of phthalates and phthalate alternatives from vinyl flooring and crib mattress covers the influence of temperature heat boosts phthalate emissions from vinyl crib mattress covers alcohol advertising in sport and non sport tv in australia during children s viewing times sport tv exposing children to thousands of alcohol advertisements per year biomechanical effects of prefabricated foot orthoses and rocker sole footwear in individuals with first metatarsophalangeal joint osteoarthritis reducing pain in patients with osteoarthritis of the big toe allogeneic ex vivo expanded corneal epithelial stem cell transplantation a randomized controlled clinical trial trial using donated eye tissue offers stem cell surgery hope placebo analgesia in patients with functional and organic abdominal pain a fmri study in ibs uc and healthy volunteers link between depression abnormal brain response to visceral pain in patients with ibs adapting to hurricanes. a historical perspective on new orleans from its foundation to hurricane katrina how has society adapted to hurricanes ? a look at new orleans over years safety efficacy and immunogenicity of vgx a therapeutic synthetic dna vaccine targeting human papillomavirus and e and e proteins for cervical intraepithelial neoplasia a randomised double blind placebo controlled phase b trial dna based vaccine clears nearly half of precancerous cervical lesions in clinical trial dairy calcium intake serum vitamin d and successful weight loss higher dairy calcium intake and increased serum vitamin d are related to greater diet induced weight loss israeli study finds health profiles of newly arrived refugee children in the united states large study sums up health issues for new child refugees to u.s. coupled thermo mechanical analysis of shape memory alloy circular bars in pure torsion seismic resistance model analyzes shape memory alloys for use in earthquake resistant structures how gender norms are reinforced through violence against adolescent girls in two conflict affected populations violence against girls in conflict affected populations reinforces gender norms design and analysis of wearable pupillometer for autonomic neuropathy of diabetic patients wearable device for early detection of common diabetes related neurological condition enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species mediated inactivation of focal adhesion kinase phosphatases beneficial bacteria help repair intestinal injury by inducing reactive oxygen species thyroid hormone controls cone opsin expression in the retina of adult rodents. thyroid hormone controls the eye s visual pigments throughout life large granulation cells on the surface of the giant star gruis giant bubbles on red giant star s surface underpinning the repurposing of anthracyclines towards colorectal cancer assessment of topoisomerase ii alpha gene copy number alterations in colorectal cancer genetic aberration paves the way for new treatment of cancer disease wnt a mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and klf mediated differentiation inherited rare skin disease informs treatment of common hair disorders study finds slip rate variability and distributed deformation in the marmara sea fault system earthquake risk seismic gap south of istanbul poses extreme danger baroreflex dysfunction and augmented sympathetic nerve responses during mental stress in veterans with posttraumatic stress disorder ptsd veterans with ptsd have an increased fight or flight response use of acid suppression medication is associated with risk for c. difficile infection in infants and children a population based study acid reducing medications sharply raise risk of c. difficile bacteria infection in kids false beliefs and confabulation can lead to lasting changes in political attitudes. induced changes to political attitude can last over time the special supplemental nutrition program for women infants and children wic food package change and children s growth trajectories and obesity in los angeles county improved wic food packages reduced obesity risk for children study finds age estimates for hominin fossils and the onset of the upper palaeolithic at denisova cave deep history of archaic humans in southern siberia identification of sieve elements and companion cell protoplasts by a combination of brightfield and fluorescence microscopy new technique to identify phloem cells aids in the fight against citrus greening mining unexplored chemistries for phosphors for high color quality white light emitting diodes computers aid discovery of new inexpensive material to make leds with high color quality effects of school based interventions with u.s. military connected children a systematic review school based interventions could benefit children from military families dacar cas somali red aloe a new species of aloe asphodelaceae from somaliland aloe sanginalis a new red aloe from somaliland z dna forming silencer in the first exon regulates human adam gene expression adam gene could hold key to cancer arthritis and cardiac treatments genetic dissection of the circuit for hand dexterity in primates controlling hand movements manipulation of specific neural circuit buried in complicated brain networks in primates a decorated raven bone from the zaskalnaya vi kolosovskaya neanderthal site crimea a decorated raven bone discovered in crimea may provide insight into neanderthal cognition existence of neural crest derived progenitor cells in normal and fuchs endothelial dystrophy corneal endothelium researchers find proliferating cells in normal diseased corneal endothelium host pathogen evolutionary signatures reveal dynamics and future invasions of vampire bat rabies scientists use genetic analysis to forecast spatial expansion of rabies in peru fiber supplementation influences phylogenetic structure and functional capacity of the human intestinal microbiome follow up of a randomized controlled trial shift in gut bacteria observed in fiber supplement study may offer good news for weight loss trends in epidemiology of pediatric inflammatory bowel disease in canada distributed network analysis of multiple population based provincial health administrative databases inflammatory bowel diseases on the rise in very young canadian children generating mouse models of degenerative diseases using cre lox mediated in vivo mosaic cell ablation new mouse model may lead to new therapies for degenerative diseases age and alzheimer s disease gene expression profiles reversed by the glutamate modulator riluzole experimental alzheimer s drug reverses genetic changes thought to spur the disease positive emotional contagion in a new zealand parrot for this new zealand parrot laughter is contagious depression is associated with an increased risk of psoriatic arthritis among patients with psoriasis a population based study depression puts psoriasis patients at significantly greater risk of psoriatic arthritis toward space like photometric precision from the ground with beam shaping diffusers new telescope attachment allows ground based observations of new worlds macrophage depletion ameliorates peripheral neuropathy in aging mice saving aging nerves from big eater immune cells gene pathways associated with mitochondrial function oxidative stress and telomere length are differentially expressed in the liver of rats fed lifelong on virgin olive sunflower or fish oils long term consumption of sunflower and fish oils may damage the liver vanadium oxide bandstop tunable filter for ka frequency bands based on a novel reconfigurable spiral shape defected ground plane cpw vanadium dioxide a revolutionary material for tomorrow s electronics timing of androgen receptor disruption and estrogen exposure underlies a spectrum of congenital penile anomalies researchers identify genes connecting endocrine disruption to genital malformations nanoparticle induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes nanoparticles may cause dna damage to brain cells across a cellular barrier o are family meal patterns associated with overall diet quality during the transition from early to middle adolescence ? regular family meals result in better eating habits for adolescents oral microbiome composition reflects prospective risk for esophageal cancers oral microbiota indicates link between periodontal disease esophageal cancer small intestine microbiota regulate host digestive and absorptive adaptive responses to dietary lipids specific bacteria in the small intestine are crucial for fat absorption speech error and tip of the tongue diary for mobile devices online tool enables public to track tip of the tongue states speech errors characterisation of aroma active and off odour compounds in german rainbow trout oncorhynchus mykiss. part i case of aquaculture water from earthen ponds farming a good nose in service of science when fish smells fishy optimising femoral head osteochondral allograft transplantation in a preclinical model new surgical technique improves biological hip joint replacement combining human acceptance and habitat suitability in a unified socio ecological suitability model a case study of the wolf in switzerland novel socio ecological approach helps identifying suitable wolf habitats in human dominated landscapes timing of probiotic milk consumption during pregnancy and effects on the incidence of preeclampsia and preterm delivery a prospective observational cohort study in norway women taking probiotics during pregnancy might have lower pre eclampsia and premature birth risk ppgpp couples transcription to dna repair in e. coli factor preserves dna integrity in bacteria despite assault from antibiotics a magnetically controlled soft microrobot steering a guidewire in a three dimensional phantom vascular network overcoming cardiovascular disease with a magnetically steerable guidewire microrobot enamel defects reflect perinatal exposure to bisphenol a early exposure to bisphenol a might damage the enamel of teeth effect of a behavioral intervention for underserved preschool age children on change in body mass index behavioral changes insufficient at preventing early childhood obesity a novel dominant mutation in sag the arrestin gene is a common cause of retinitis pigmentosa in hispanic families in the southwestern united states gene mutation linked to retinitis pigmentosa in southwestern us hispanic families vitamin d supplementation to prevent acute respiratory tract infections systematic review and meta analysis of individual participant data vitamin d protects against colds and flu finds major global study fetal alcohol spectrum disorder a guideline for diagnosis across the lifespan diagnosing fetal alcohol spectrum disorder new canadian guideline a commercial foot pump for emergency ventilation of horses proof of principle during equine field anaesthesia scientists confirm functionality of emergency ventilation system for horses provider perspectives on use of medical marijuana in children with cancer medical marijuana for children with cancer ? what providers think effects of mother versus artificial rearing during the first weeks of life on challenge responses of dairy cows early separation of cow and calf has long term effects on social behavior potential impacts of overlapping land use and climate in a sensitive dryland a case study of the colorado plateau usa increasing aridity and land use overlap have potential to cause social and economic conflict in dryland areas juno is the egg izumo receptor and is essential for mammalian fertilization sperm meets egg protein essential for fertilization discovered effect of implementation of a smoke free policy on physical violence in a psychiatric inpatient setting an interrupted time series analysis drop in violence associated with smoke free policy at psychiatric hospital robust photoregulation of gabaa receptors by allosteric modulation with a propofol analogue engineering a photo switch for nerve cells in the eye and brain recent ecological responses to climate change support predictions of high extinction risk one in species could face extinction decline in species shows climate change warnings not exaggerated research finds near eastern landscapes and declassified u aerial imagery declassified u spy plane images reveal bygone middle eastern archaeological features discovery and validation of a glioblastoma co expressed gene module undergraduate student uncovers genes associated with aggressive form of brain cancer outcomes among black patients with stage ii and iii colon cancer receiving chemotherapy an analysis of accent adjuvant trials survival disparities in african american and white colorectal cancer patients methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits epigenetic changes shed light on biological mechanism of autism impact of medicaid expansion on coverage and treatment of low income adults with substance use disorders medicaid expansion states see rise in coverage for low income adults with substance use disorders multi isotope analysis demonstrates significant lifestyle changes in king richard iii bone chemistry reveals royal lifestyle of richard iii a preliminary study of early onset dementia of former professional football and hockey players study of retired nfl and nhl players doesn t find evidence of early onset dementia recurrent violent injury magnitude risk factors and opportunities for intervention from a statewide analysis one in nine emergency room patients with injuries caused by violence will visit an er again within two years study finds a paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection human rotavirus manipulates immune response to maintain infection surface expression of tgf docking receptor garp promotes oncogenesis and immune tolerance in breast cancer a novel cancer immunotherapy shows early promise in preclinical studies molecular evidence of sexual transmission of ebola virus sexual transmission of ebola virus in liberia confirmed using genomic analysis impact of cpap use and age on mortality in patients with combined copd and obstructive sleep apnea the overlap syndrome cpap reduces risk of death in people with copd and sleep apnea breast cancer diagnosis using spatial light interference microscopy new optical method promises faster more accurate diagnosis of breast cancer the adaptor protein cd ap is a coordinator of neurotrophin signaling mediated axon arbor plasticity a new player revealed in nerve growth process a novel role for lipid droplets in the organismal antibacterial response new type of bacterial protection found within cells novel immune system response to infections discovered how do family physicians measure blood pressure in routine clinical practice ? do you really have high blood pressure ? cryopreservation of ovarian tissue in pediatric patients undergoing sterilizing chemotherapy a child s right to fertility preservation when undergoing sterilizing chemotherapy primordial black hole scenario for the gravitational wave event gw did the ligo gravitational waves originate from primordial black holes ? time for a model list of essential diagnostics to improve global health experts call for a standard list of essential diagnostic tests ecosystem restructuring along the great barrier reef following mass coral bleaching ne australian marine heatwave shakes up coral reef animal populations weight history smoking physical activity and breast cancer risk among french canadian women non carriers of more frequent brca mutations breast cancer risk increases for smokers and overweight women traumatic brain injury and early life experiences among men and women in a prison forty percent of ontario female prisoners enter correctional system with a traumatic brain injury abacavir u lamivudine versus tenofovir u emtricitabine for initial hiv therapy new study released on world aids day measures hiv anti retroviral regimens safety and efficacy full chain health impact assessment of traffic related air pollution and childhood asthma up to percent of all annual childhood asthma cases in bradford u.k. may be caused by air pollution preliminary evidence that high levels of nicotine on children s hands may contribute to overall tobacco smoke exposure kids hands may be a source of significant nicotine exposure deciphering microbial interactions in synthetic human gut microbiome communities dynamic modeling helps predict the behaviors of gut microbes callous unemotional traits and brain structure sex specific effects in anterior insula of typically developing youths callous and unemotional traits show in brain structure of boys only study finds updip rupture of the sumatra earthquake extended by thick indurated sediments stiff sediments made sumatra earthquake deadliest in history using cultural ecosystem services to inform restoration priorities in the laurentian great lakes new ultra detailed maps of great lakes recreational use will inform restoration priorities application of fluorescent protein expressing strains to evaluation of anti tuberculosis therapeutic efficacy in vitro and in vivo looking at the bacteria inside new method of viewing tb bacteria fruit and vegetable consumption in adolescence and early adulthood and risk of breast cancer population based cohort study high fruit intake during adolescence linked with lower breast cancer risk the myeloarchitecture of impulsivity premature responding in youth is associated with decreased myelination of ventral putamen young people at risk of addiction have differences in key brain region two year impact of the alternative quality contract on pediatric health care quality and spending new quality payment initiative positively impacts pediatric care tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy drug compound halts alzheimer s related damage in mice analysis of esr mutation in circulating tumor dna demonstrates evolution during therapy for metastatic breast cancer blood test detects when hormone treatment for breast cancer stops working plasticity of hopx type i alveolar cells to regenerate type ii cells in the lung limber lungs one type of airway cell can regenerate another lung cell type the budding yeast rsc complex maintains ploidy by promoting spindle pole body insertion avoiding catastrophe yeast study reveals clues to maintaining genome size marine heatwave causes unprecedented regional mass bleaching of thermally resistant corals in northwestern australia impact of coral bleaching on western australia s coastline the prevalence of amblyopia in germany data from the prospective population based gutenberg health study good eyes but poor vision an indistinct world for one in increased susceptibility to metabolic dysregulation in a mouse model of alzheimer s disease is associated with impaired hypothalamic insulin signaling and elevated bcaa levels brain insulin resistance identified as possible new link between alzheimer s disease diabetes impact of fine particulate matter pm. exposure during wildfires on cardiovascular health outcomes air pollution from wildfires may ignite heart hazards recovery of gene diversity using long term cryopreserved spermatozoa and artificial insemination in the endangered black footed ferret critically endangered species successfully reproduced using frozen sperm from ferret dead for years international federation of gynecology and obstetrics opinion on reproductive health impacts of exposure to toxic environmental chemicals exposure to toxic chemicals threatening human reproduction and health risk of acute respiratory infection from crop burning in india estimating disease burden and economic welfare from satellite and national health survey data for persons india s stubble burning air pollution causes usd billion economic losses health risks rapid recovery of patagonian plant insect associations after the end cretaceous extinction patagonian fossil leaves reveal rapid recovery from dinosaur extinction event key to syagrus identification using leaflet margin anatomy supplement to a revision of syagrus arecaceae first few millimeters of the leaf margin identify palm species in a new key to syagrus the detection of a hot molecular core in the large magellanic cloud with alma astronomy discovery of an extragalactic hot molecular core a method for mapping regional oxygen and co transfer in the lung researchers develop new method for looking into the lungs acute myocardial infarction during pregnancy and the puerperium in the united states heart attack risk on the rise for pregnant women and death rate remains high a missense mutation in damage specific dna binding protein is a genetic risk factor for limbal squamous cell carcinoma in horses genetic risk factor for equine eye cancer identified inhibition of sperm motility in male macaques with ep a potential non hormonal male contraceptive male contraceptive compound stops sperm without affecting hormones study in monkeys acupuncture improves exercise tolerance of patients with heart failure a placebo controlled pilot study acupuncture improves exercise tolerance in heart patients german study finds transmission rates of ca. liberibacter asiaticus by asian citrus psyllid are enhanced by the presence and developmental stage of citrus flush plant breeders growers should pay attention to flush in fight against citrus greening disease is math anxiety always bad for math learning ? the role of math motivation math anxiety doesn t equal poor math performance the impact of preparation and support procedures for children with sickle cell disease undergoing mri intervention helps children with sickle cell disease complete mri tests without sedation similar estimates of temperature impacts on global wheat yield by three independent methods global food security aided by combining different methods consuming high protein soy snacks affects appetite control satiety and diet quality in young people and influences select aspects of mood and cognition snacking on protein can improve appetite control diet quality in teens p shca promotes breast cancer plasticity by inducing an epithelial to mesenchymal transition new biomarker highly promising for predicting breast cancer outcomes chemical warfare between leafcutter ant symbionts and a co evolved pathogen deadly behavior modifying weapon identified in insect world chemical arms race gpr signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice and its inhibition increases effects of gemcitabine cannabinoid improves survival rates of mice with pancreatic cancer tree root system characterization and volume estimation by terrestrial laser scanning and quantitative structure modeling new information on environmental impacts of stump wood energy through d modeling terminal pleistocene epoch human footprints from the pacific coast of canada year old human footprints found off canada s pacific coast total body cd t cell dynamics in treated and untreated siv infection revealed by in vivo imaging imaging technique illuminates immune status of monkeys with hiv like virus generation of spatial patterned early developing cardiac organoids using human pluripotent stem cells d tissue model of developing heart could help drug safety testing for pregnant women barriers to accessing hiv prevention in clinic settings higher alcohol use and more sex partners predict decreased exposure to hiv prevention counseling double whammy of multiple sex partners drinking in hiv sti prevention nav. overexpressing interneuron transplants restore brain rhythms and cognition in a mouse model of alzheimer s disease cell therapy could improve brain function for alzheimer s disease single cell genome wide bisulfite sequencing for assessing epigenetic heterogeneity new technique maps life s effects on our dna powerful single cell technique to study environmental effects on dna long term variability of importance of brain regions in evolving epileptic brain networks new analysis of brain network activity offers unique insight into epileptic seizures the history genome and biology of nctc a non pandemic vibrio cholerae isolate from world war one genetic code of wwi soldier s cholera mapped rtog efficacy of bevacizumab in combination with definitive radiation therapy and cisplatin chemotherapy in untreated patients with locally advanced cervical carcinoma phase ii trial of bevacizumab svastin in locally advanced cervical cancer found promising cranial variation and biodistance in three imperial roman cemeteries ancient skulls shed light on migration in the roman empire oncogenes activate an autonomous transcriptional regulatory circuit that drives glioblastoma researchers discover potential new target for treating glioblastoma risk of colon cancer and coffee tea and sugar sweetened soft drink intake pooled analysis of prospective cohort studies coffee and soft drinks have little or no association with colon cancer risk study finds cellular inhibitor of apoptosis protein ciap protects against pulmonary tissue necrosis during influenza virus infection to promote host survival new avenues for influenza control suggested by identification of an enzyme that plays a crucial role in resistance to the infection prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis lower occurrence of atopic dermatitis in children whose mothers were exposed to farm animals and cats during pregnancy belowground carbon trade among tall trees in a temperate forest forest discovery trees trade carbon among each other systematic chemical mutagenesis identifies a potent novel apratoxin a e hybrid with improved in vivo antitumor activity medicinal chemists modify sea bacteria byproduct for use as potential cancer drug number of drinks to feel a buzz by hiv status and viral load in men a bad buzz men with hiv need fewer drinks to feel effects scaling up international food aid food delivery alone cannot solve the malnutrition crisis international food aid alone cannot solve the global malnutrition crisis experts argue mapping of the disease locus and identification of adamts as a candidate gene in a canine model of primary open angle glaucoma identification of glaucoma gene brightens view for future therapies blockade of chronic type i interferon signaling to control persistent lcmv infection blocking immune response protein helps body clear chronic infection potential therapy for hiv other viral infections ? ingesting a carbohydrate electrolyte solution improves endurance capacity but not sprint performance during intermittent high intensity shuttle running in adolescent team games players aged years energy drinks may give young sports teams an edge study says robust prognostic gene expression signatures in bladder cancer and lung adenocarcinoma depend on cell cycle related genes lung bladder cancers have common cell cycle biomarkers infant attachment security and early childhood behavioral inhibition interact to predict adolescent social anxiety symptoms shy babies need secure parent bond to help prevent potential teen anxiety a mechanistic hydro epidemiological model of liver fluke risk climate change increasing the prevalence of harmful parasite warn scientists ebola virus entry requires the cholesterol transporter niemann pick c scientists identify point of entry for deadly ebola virus deconvoluting complex structural histories archived in brittle fault zones new study describes million years of geological evolution utilization of long acting reversible contraceptives in the united states after vs before the us presidential election demand for long acting contraception rose sharply after election longitudinal cortical development during adolescence and young adulthood in autism spectrum disorder increased cortical thinning but comparable surface area changes longitudinal brain changes during transition from adolescence to adulthood found in asd pot loss of function variants predispose to familial melanoma genetic mutations warn of skin cancer risk new high risk cancer causing mutation identified for melanoma development cognitive heterogeneity among community dwelling older adults with cerebral small vessel disease absentmindedness points to earlier warning signs of silent strokes among people at risk quantitative whole genome sequencing of circulating tumor cells enables personalized combination therapy of metastatic cancer genome sequencing method can detect clinically relevant mutations using ctcs climate change surpasses land use change in the contracting range boundary of a winter adapted mammal no snow no hares climate change pushes emblematic species north warm summers during the younger dryas cold reversal collapse of the atlantic ocean heat transport might lead to hot european summers fifteen new risk loci for coronary artery disease highlight arterial wall specific mechanisms new heart disease risk genes point to flaws in blood vessel walls the ntds and vaccine diplomacy in latin america opportunities for united states foreign policy tropical disease prevalence in latin america presents opportunity for u.s. increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children asthma exacerbation and large doses of inhaled corticosteroids the natural history of respiratory syncytial virus in a birth cohort the influence of age and previous infection on reinfection and disease potential vaccine strategies to protect babies from respiratory syncytial virus in utero crispr mediated therapeutic editing of metabolic genes guided by crispr prenatal gene editing shows proof of concept in treating disease before birth reconstructing the deep population history of central and south america ancient dna evidence reveals two unknown migrations from north to south america deletion of iron regulatory protein causes polycythemia and pulmonary hypertension in mice through translational derepression of hif lack of iron regulating protein contributes to high blood pressure of the lungs mast cell interleukin drives localized tolerance in chronic bladder infection defect in immune memory may cause repeat bladder infections clinical doses of radiation reduce collagen matrix stiffness ionizing radiation found to soften tumor cell microenvironment the growth of finfish in global open ocean aquaculture under climate change climate change population growth may lead to open ocean aquaculture retinal mmp mmp timp and timp expression in murine experimental retinal detachment advancements in retinal detachment research pave the road to better visual recovery weight gain effects of second generation antipsychotic treatment in autism spectrum disorder weight gain studied for second generation antipsychotics for autism spectrum disorders simultaneous targeting of il and il is required for protection against inflammatory and septic shock potential novel treatment against septic shock one of the leading causes of mortality in icus mental health perceptions and practices of a cree community in northern ontario a qualitative study aboriginal community with strong ethno cultural identity and connection to the land has lower suicide rates reconstructing paternal genotypes to infer patterns of sperm storage and sexual selection in the hawksbill turtle dna reveals mating patterns of critically endangered sea turtle co benefits of addressing climate change can motivate action around the world praying for plan b how a higher power can inspire climate change action iodide management in formamidinium lead halide based perovskite layers for efficient solar cells new world efficiency record with perovskite solar cells quantum and classical phases of the pyrochlore heisenberg model with competing interactions new insights into magnetic quantum effects in solids post hospital outcomes of patients with acute myocardial infarction with cardiogenic shock findings from the ncdr heart attack patients with cardiogenic shock fair well days post discharge two new endemic tree species from puerto rico pisonia horneae and pisonia roqueae nyctaginaceae two caribbean bird catcher trees named after two women with overlooked botanical works proteogenomic integration reveals therapeutic targets in breast cancer xenografts novel approach can reveal personalized breast cancer treatments profiling abusive men based on women s self reports findings from a sample of urban low income minority women over half of women in abusive relationships still saw their male partners as dependable sex differences in outcomes of heart failure in an ambulatory population based cohort from to death rates from heart failure higher for women than men naive pluripotent stem cells derived directly from isolated cells of the human inner cell mass scientists develop very early stage human embryonic stem cell lines for first time night shift work increases the risks of multiple primary cancers in women a systematic review and meta analysis of articles female night shift workers may have increased risk of common cancers sensitivity of plain pelvis radiography in children with blunt torso trauma most kids with blunt torso trauma can skip the pelvic x ray hindrance and challenge stressors and well being based work non work interference a diary study of portfolio workers new study of freelance workers examines link between their well being and hours worked contemporaneous radiations of fungi and plants linked to symbiosis a billion years of coexistence between plants and fungi early metformin therapy age years in girls with precocious pubarche to reduce hirsutism androgen excess and oligomenorrhea in adolescence diabetes drug may prevent or delay development of polycystic ovary syndrome the most common cause of infertility in women autotaxin is related to metabolic dysfunction and predicts alzheimer s disease outcomes new biomarker predicts alzheimer s disease link to diabetes relation of obesity to new onset atrial fibrillation and atrial flutter in adults obesity linked with higher chance of developing rapid irregular heart rate nilotinib effects in parkinson s disease and dementia with lewy bodies cancer drug restores brain dopamine reduces toxic proteins in parkinson dementia low dose arsenic compromises the immune response to influenza a infection in vivo swine flu influenza a h n susceptibility linked to common levels of arsenic exposure diet dependent gene expression in honey bees honey vs. sucrose or high fructose corn syrup scientists track gene activity when honey bees do and don t eat honey significant differences depending on diet loss of function mutation in the palmitoyl transferase hhat leads to syndromic xy disorder of sex development by impeding hedgehog protein palmitoylation and signaling journey between xx xy getting closer to unravelling mystery of sexual ambiguity food combination and alzheimer disease risk a protective diet food combination associated with reduced alzheimer s disease risk identified in new study dementia incidence trend over in the netherlands analysis of primary care data incidence of dementia in primary care increased in the netherlands over years cyanobacteria use micro optics to sense light direction slime can see tiny cyanobacteria use principle of the lens in the human eye to perceive light direction common proteomic changes in the hippocampus in schizophrenia and bipolar disorder and particular evidence for involvement of cornu ammonis regions and major brain similarities found in bipolar disorder and schizophrenia aavshrna mediated suppression of pten in adult rats in combination with salmon fibrin administration enables regenerative growth of corticospinal axons and enhances recovery of voluntary motor function after cervical spinal cord injury gene inhibitor salmon fibrin restore function lost in spinal cord injury in rodents trace metals as biomarkers for eumelanin pigment in the fossil record x rays reveal patterns in the plumage of the first birds the effects of process focused versus experience focused narratives in a breast cancer treatment decision task different stories play different roles in patients health decision making aghalo a facile fluorogenic sensor to detect drug induced proteome stress new more sensitive sensor for evaluating drug safety depth and coral cover drive the distribution of a coral macroborer across two reef systems boring barnacles prefer the shallow life on coral reefs rotating polygonal depression soliton clusters on the inner surface of a liquid ring decoding the movement patterns of tsunami like solitary waves hiv shedding from male circumcision wounds in hiv infected men a prospective cohort study as circumcision wounds heal hiv positive men may spread virus to female partners uganda study food pricing strategies population diets and non communicable disease a systematic review of simulation studies taxes on sugary drinks and high fat foods could improve health experts say juno sees the gas giant from new angles juno mission to jupiter delivers first science results preoperative chemoprophylaxis is safe in major oncology operations and effective at preventing venous thromboembolism preoperative use of blood thinning drugs is safe for cancer patients a dynamic bronchial airway gene expression signature of copd and lung function impairment novel approach to study copd and treatment efficacy identified excess plac promotes an unconventional erk dependent emt in colon cancer likely culprit in spread of colon cancer identified weight related behaviors when children are in school versus on summer breaks does income matter ? obesity related behaviors increase when school s out instability of insular tree communities in an amazonian mega dam is driven by impaired recruitment and altered species composition experts warn against mega dams in lowland tropical forests genes count attenuated cerebral vasodilator capacity in young african americans african americans at greater risk from stroke and other cerebrovascular diseases self esteem self efficacy and appearance assessment of young female patients undergoing facial cosmetic surgery self esteem among young women undergoing facial plastic surgery in china living near major roads and the incidence of dementia parkinson s disease and multiple sclerosis a population based cohort study living near major traffic linked to higher risk of dementia gram positive bacteria are held at a distance in the colon mucus by the lectin like protein zg newly discovered bacteria binding protein in the intestine semi automated software for dorsal fin photographic identification of marine species application to carcharodon carcharias new software will standardize data collection for great white sharks high resolution measurement of the unsteady velocity field to evaluate blood damage induced by a mechanical heart valve super sized heart valve provides clues to blood flow hormonal contraception and the risk of hiv acquisition an individual participant data meta analysis risk of hiv infection in studies of african women using hormonal contraceptives treatment for preventing tuberculosis in children and adolescents shorter combination treatment as effective as monotherapy for tb prevention in kids self assembly of tunable protein suprastructures from recombinant oleosin natural plant protein converted into drug delivery vehicles molecular diagnosis of subcutaneous pythium insidiosum infection by use of pcr screening and dna sequencing rare emerging disease claims texas girl s leg pcr plus sequencing identified culprit porphyromonas gingivalis in alzheimer s disease brains evidence for disease causation and treatment with small molecule inhibitors new science details discovery of bacterial pathogen in brains of alzheimer s patients temporary refugia for coral reefs in a warming world new maps depict potential worldwide coral bleaching by intravenous bone marrow stem cell grafts preferentially migrate to spleen and abrogate chronic inflammation in stroke spleen may provide new target for treating stroke s debilitating chronic inflammation fluorinated naphtho c c bis thiadiazole containing conjugated compound synthesis properties and acceptor applications in organic solar cells controlling organic semiconductor band gaps by electron acceptor fluorination unexpected levels of biological activity during the polar night offer new perspectives on a warming arctic in the dark polar winter the animals aren t sleeping textbooks of doubt using systemic functional analysis to explore the framing of climate change in middle school science textbooks california th grade science books climate change a matter of opinion not scientific fact early adult to mid life cardiovascular risk factors and cognitive function heart health as young adult linked to mental function in mid life museum genomics confirms that the lord howe island stick insect survived extinction once declared extinct lord howe island stick insects really do live translating effective web based self help for problem drinking into the real world web based self help intervention can aid problem drinkers in the privacy of their homes spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm stem cell research provides hope for infertile cancer survivors transplanted stem cells could preserve male fertility high mortality in aquatic predators of mosquito larvae caused by exposure to insect repellent widely used mosquito repellent proves lethal to larval salamanders effects of exposure to rocket attacks on adolescent distress and violence a year longitudinal study exposure to rocket attacks in israel increases adolescent violence protecting health care workers from ebola personal protective equipment is critical but is not enough for ebola health care workers how protective gear is removed poses risk of deadly exposure experts caution illinois river nitrate nitrogen concentrations and loads long term variation and association with watershed nitrogen inputs illinois river water quality improvement linked to more efficient corn production dna methylation dynamics of human hematopoietic stem cell differentiation beyond the dna comprehensive map of the human epigenome completed school based randomized controlled trial of an hiv std risk reduction intervention for south african adolescents school based program reduces risky sexual behaviors in south african teens frailty and famine patterns of mortality and physiological stress among victims of famine in medieval london skeletal marker of physiological stress might indicate good rather than poor health mineralized state of the avian influenza virus in the environment mineral layer around avian flu pathogen may be the cause for human infections identification of younger dryas outburst flood path from lake agassiz to the arctic ocean ice sheet melt identified as trigger of big freeze mutations in fus an rna processing protein cause familial amyotrophic lateral sclerosis type second motor neuron disease gene mutation in one year signifies rapid research progress barriers benefits and beliefs of brain training smartphone apps an internet survey of younger us consumers consumers reveal barriers to brain training app iness online advertising for cancer prevention google ads and tanning beds online advertising can deliver targeted cancer prevention messages doubles trouble cases of ocular trauma in badminton clinical features and prevention doubles badminton players may be at highest risk of serious eye injury during play the amphibians of mount oku cameroon an updated species inventory and conservation review twenty five frogs added to the amphibian fauna of mount oku cameroon acute liver failure in neonates with undiagnosed hereditary fructose intolerance due to exposure from widely available infant formulas sugars in infant formulas pose risk to babies with inherited metabolic disorder conditional genome engineering in toxoplasma gondii uncovers alternative invasion mechanisms study turns parasite invasion theory on its head jamb and jamc are essential for vertebrate myocyte fusion the mystery behind the building of muscle jamb and jamc are essential proteins for the fusion of muscle cells the effects of weeks of soccer or resistance training on body composition and muscle function in year old healthy males a randomized controlled trial football training reduces the risk of disease in elderly men defining optimal length of opioid pain medication prescription after common surgical procedures defining optimal opioid pain medication prescription length following surgery reconstructing asian faunal introductions to eastern africa from multi proxy biomolecular and archaeological datasets early indian ocean trade routes bring chicken black rat to eastern africa the possible role of local air pollution in climate change in west africa scientists warn of the risk from air pollution over the megacities of west africa underwater leidenfrost nanochemistry for creation of size tailored zinc peroxide cancer nanotherapeutics anticancer nanomaterials created by simulating underwater volcanic conditions adaptive evolution of the venom targeted vwf protein in opossums that eat pitvipers rapid venom evolution in pit vipers may be defensive marsupials that prey on venomous snakes also evolve rapidly consequences of twenty first century policy for multi millennial climate and sea level change long term picture offers little solace on climate change a thalamocortical neural mass model of the eeg during nrem sleep and its response to auditory stimulation sleeping brain s complex activity mimicked by simple model ifn beta improves bcg immunogenicity by acting on dc maturation new discovery gives tuberculosis vaccine a shot in the arm improving vertebrate skeleton images fluorescence and the non permanent mounting of cleared and stained specimens state of the art imaging techniques reveal heightened detail and beauty of vertebrate life the curious case of koi confirming kepler s first exoplanet detection kepler space telescope s first exoplanet candidate confirmed massively parallel de novo protein design for targeted therapeutics mini protein rapid design method opens way to create a new class of drugs estimated reductions in cardiovascular and gastric cancer disease burden through salt policies in england an impact ncd microsimulation study current uk salt reduction strategies do not address health inequalities global nickel anomaly links siberian traps eruptions and the latest permian mass extinction siberian volcanic eruptions caused extinction million years ago new evidence shows biological and physical effects of brine discharge from the carlsbad desalination plant and implications for future desalination plant constructions study of brine discharge from desalination plant finds good news and bad news prenatal depression and birth mode sequentially mediate maternal education s influence on infant sleep duration infant sleep duration associated with mother s level of education and prenatal depression more losers than winners in a century of future southern ocean seafloor warming more losers than winners predicted for southern ocean seafloor animals human neural stem cell transplantation ameliorates radiation induced cognitive dysfunction stem cells restore cognitive abilities impaired by brain cancer treatment subtype specific promoter driven action potential imaging for precise disease modelling and drug testing in hipsc derived cardiomyocytes luminous heart cells jellyfish proteins assist in heart rhythm disorder research postmenopausal female hormone use and estrogen receptor positive and negative breast cancer in african american women female hormone supplements with estrogen progestin linked to breast cancer risk spatial variability in tree regeneration after wildfire delays and dampens future bark beetle outbreaks variable tree growth after fire protects forests from future bark beetle outbreaks direct tracking of amyloid and tu dynamics in neuroblastoma cells using nanoplasmonic fiber tip probes nanoprobe enables measurement of protein dynamics in living cells aerobic fitness and neurocognitive function scores in young faroese adults and potential modification by prenatal methylmercury exposure brain benefits of aerobic exercise lost to mercury exposure demonstration of cross protective vaccine immunity against an emerging pathogenic ebolavirus species experimental vaccine protects monkeys from new ebola virus endocranial morphology of the primitive nodosaurid dinosaur pawpawsaurus campbelli from the early cretaceous of north america early armored dinosaur from texas lacked cousin s club tail weapon but had a nose for danger alcohol related mortality in deprived uk cities worrying trends in young women challenge recent national downward trends worrying rise in alcohol deaths among young women in england and scotland periodontitis and cognitive decline in alzheimer s disease link between gum disease and cognitive decline in alzheimer s citizen science in schools students collect valuable mammal data for science conservation and community engagement students around the globe collect quality eye opening research data on mammals post fire logging reduces surface woody fuels up to four decades following wildfire post fire logging can reduce fuels for up to years in regenerating forests new study finds western us volcanism due to intruding oceanic mantle driven by ancient farallon slabs heat from below pacific ocean fuels yellowstone study finds proposal to disregard athletics world records prior to a radical and misjudged initiative ditch plan to disregard all athletic world records before urge experts evidence that the endometrial microbiota has an effect on implantation success or failure uterine microbiota play a key role in implantation and pregnancy success in in vitro fertilization dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in d. melanogaster does dietary restriction protect against age related leaky gut ? predicting vertical urban growth using genetic evolutionary algorithms in tokyo s minato ward a genetic algorithm predicts the vertical growth of cities the return on investment of a medicaid tobacco cessation program in massachusetts a smoking cessation benefit can save money for medicaid nuclear pkm regulates catenin transactivation upon egfr activation metabolic protein plays unexpected role in tumor cell formation and growth the effect of early growth patterns and lung function on the development of childhood asthma a population based study growth in first years of life affects respiratory health in children kindness reduces avoidance goals in socially anxious individuals doing good deeds helps socially anxious people relax year physical activity trajectories and development of subclinical coronary artery disease as measured by coronary artery calcium physically active white men at high risk for plaque buildup in arteries hivma of idsa clinical practice guideline for the management of chronic pain in patients living with hiv chronic pain common in people living with hiv frontal networks in adults with autism spectrum disorder brain subtle brain differences seen in men with autism ectopic expression of germline genes drives malignant brain tumor growth in drosophila some brain tumors mimic the genetic program of germline cells eliminating microglia in alzheimer s mice prevents neuronal loss without modulating amyloid pathology blocking inflammation prevents cell death improves memory in alzheimer s disease language underperformance in young children who are deaf or hard of hearing study raises expectations for improved language skills in the deaf and hard of hearing upper esophageal sphincter and gastroesophageal junction pressure changes act to prevent gastroesophageal and esophagopharyngeal reflux during apneic episodes in patients with obstructive sleep apnea link between acid reflux and sleep apnea challenged preliminary efficacy of adapted responsive teaching for infants at risk of autism spectrum disorder in a community sample simple strategies used by parents lead to improvements in one year olds at risk for autism spectrum disorder pandemic h n influenza vaccine induces a recall response in humans that favors broadly cross reactive memory b cells pandemic h n vaccination produces antibodies against multiple flu strains germline genetic variation in etv and risk of childhood acute lymphoblastic leukaemia a systematic genetic study inherited gene variation linked to an increased risk of the most common childhood cancer treatment of severe adult traumatic brain injury using bone marrow mononuclear cells stem cell therapy appears to have tbi treatment effect extent of smoking and age at initiation of smoking among adult survivors of childhood cancer in britain one fifth of british adult survivors of childhood cancer smoke despite hazards fenamate nsaids inhibit the nlrp inflammasome and protect against alzheimer s disease in rodent models new treatment option for alzheimer s disease possible say researchers interspecies sexual behaviour between a male japanese macaque and female sika deer unlikely couple liaison between a sika deer and a japanese snow monkey rapid determination of anti tuberculosis drug resistance from whole genome sequences new online tool to predict genetic resistance to tuberculosis drugs an examination of the associations between facial structure aggressive behavior and performance in the world cup association football players facial structure predicts goals fouls among world cup soccer players an essential role for the il receptor in treg cell function key requirement for regulatory t cell function discovered intersex condition and molecular markers of endocrine disruption in relation with burdens of emerging pollutants in thicklip grey mullets chelon labrosus from basque estuaries south east bay of biscay more male fish feminized by pollution on basque coast integrating wood fuels into agriculture and food security agendas and research in sub saharan africa wood fuels key to easing food insecurity situation in sub saharan africa local functional overconnectivity in posterior brain regions is associated with symptom severity in autism spectrum disorders social symptoms in autistic children may be caused by hyper connected neurons trna fragments show intertwining with mrnas of specific repeat content and have links to disparities fragments of cellular machinery reveal unexpected variability among cancers double layered protein nanoparticles induce broad protection against divergent influenza a viruses nanoparticle vaccine offers universal protection against influenza a viruses study finds prevalence of submandibular gland synucleinopathy in parkinson s disease dementia with lewy bodies and other lewy body disorders tissue biomarker for dementia with lewy bodies and parkinson s disease isolation of potent neutralizing antibodies from a survivor of the ebola virus outbreak researchers discover new ebola fighting antibodies in blood of outbreak survivor a long acting formulation of the integrase inhibitor raltegravir protects humanized blt mice from repeated high dose vaginal hiv challenges long acting injectable protects against vaginal hiv transmission evolution of nonspectral rhodopsin function at high altitudes scientists demonstrate adaptation of animal vision in extreme environments pparg post translational modifications regulate bone formation and bone resorption new drug candidate could treat both type diabetes bone loss protein phosphatase mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma asthma study provides paradigm shift in understanding of life threatening condition a new species of dystacta saussure from nyungwe national park rwanda insecta mantodea dystactinae student discovers new praying mantis species in rwanda female bush tiger mantis hunts prey on ground and underbrush trade offs in cervical cancer prevention balancing benefits and risks benefits and risks of cervical cancer screening methods reversing behavioral neuroanatomical and germline influences of intergenerational stress reversing influences of intergenerational stress offers hope for addressing public health environmental enrichment may protect against hippocampal atrophy in the chronic stages of traumatic brain injury environmental enrichment for traumatic brain injury patients may reduce shrinkage in brain visual recognition memory is impaired in rhesus monkeys repeatedly exposed to sevoflurane in infancy visual recognition memory impaired after multiple exposures to anesthesia during infancy building a job exposure matrix for early plutonium workers at the sellafield nuclear site united kingdom new method could shed light on workers historical radiation exposure rank ligand as a potential target for breast cancer prevention in brca mutation carriers holy grail of breast cancer prevention in high risk women may be in sight transfusion of plasma platelets and red blood cells in a vs a ratio and mortality in patients with severe trauma study compares effectiveness of different transfusion strategies for severe trauma in crystallo thermodynamic analysis of conformational change of the topaquinone cofactor in bacterial copper amine oxidase enzyme s unfrozen adventure in crystallo protein thermodynamics implementing goal directed foraging decisions of a simpler nervous system in simulation virtual predator is self aware behaves like living counterpart exploring a possible connection between u.s. tornado activity and arctic sea ice possible connection between u.s. tornado activity arctic sea ice a high energy density lithium oxygen battery based on a reversible four electron conversion to lithium oxide chemists make breakthrough on road to creating a rechargeable lithium oxygen battery local changes in network structure contribute to late communication recovery after severe brain injury scientists track restoration of communication in minimally conscious patient risk of second primary tumors in men diagnosed with prostate cancer a population based cohort study radiation for prostate cancer linked to secondary cancers study finds noncoding somatic and inherited single nucleotide variants converge to promote esr expression in breast cancer breast cancer researchers look beyond genes to identify more drivers of disease development prevention and treatment produced large decreases in hiv incidence in a model of people who inject drugs combination approach reduces spread of drug related hiv in new computer model evidence of systematic triggering at teleseismic distances following large earthquakes earthquakes can systematically trigger other ones on opposite side of earth fear thou not activity of frontal and temporal circuits in moments of real life courage brave brains neural mechanisms of courage uncovered in study of fear of snakes theory of chaotic orbital variations confirmed by cretaceous geological evidence from rocks in colorado evidence of a chaotic solar system alcohol mixed with energy drink use and sexual risk taking casual intoxicated and unprotected sex consumption of alcohol energy drink mixes linked with casual risky sex cracking the code of biodiversity responses to past climate change adapt move or die how biodiversity reacted to past climate change variants in the cd gene associate with the metabolic syndrome and high density lipoprotein cholesterol gene variants linked to metabolic syndrome and hdl cholesterol levels identification of genetic factors that modify motor performance and body weight using collaborative cross mice scientists identify genetic factors that influence body weight and neurological disorders significant fraction of co emissions from boreal lakes derived from hydrologic inorganic carbon inputs northern lakes act as carbon dioxide chimneys in a warming world an in vitro human lens capsular bag model adopting a graded culture regime to assess putative impact of iols on pco formation a human model to test implants for cataract surgery recent increases in arctic freshwater flux affects labrador sea convection and atlantic overturning circulation melting greenland ice sheet may affect global ocean circulation future climate adolescent diet and metabolic syndrome in young women results of the dietary intervention study in children disc follow up study childhood diet lower in fat and higher in fiber may lower risk for chronic disease in adulthood remission induction and maintenance effect of probiotics on ulcerative colitis a meta analysis which treatment is effective in maintaining remission in ulcerative colitis probiotic or placebo ? on the existence of a threshold for preventive behavioral responses to suppress epidemic spreading researchers explore social media as preventative method for infectious diseases crawling without wiggling muscular mechanisms and kinematics of rectilinear locomotion in boa constrictors expert unlocks mechanics of how snakes move in a straight line the influence of musculoskeletal conditions behavioral health diagnoses and demographic factors on injury related outcome in a high demand population veterans with muscle injuries and mental health conditions more likely to end service neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter implications for alzheimer disease epilepsy drug shows potential for alzheimer s treatment non endoscopic deactivation of nerve triggers in migraine headache patients surgeons report significant migraine relief from cosmetic eyelid surgery technique multiple mechanisms confer stability to isolated populations of a rare endemic plant research provides insight on survivability of rare wyoming plant effect of short term supplementation with ready to use therapeutic food or micronutrients for children after illness for prevention of malnutrition a randomised controlled trial in uganda alleviating malnutrition in children in resource limited and conflict areas psychotic disorders induced by antiepileptic drugs in people with epilepsy some psychotic disorders may be induced by drugs designed to combat effects of epilepsy the structure of cenp a ?h reveals physical features that mark centromeres at the crossroads of chromosomes study reveals structure of cell division s key molecule persistence of greater sage grouse in agricultural landscapes federally subsidized shrubs grasses crucial to sage grouse survival in washington virtual reality social cognition training for children with high functioning autism virtual reality training improves social skills of individuals on the autism spectrum genetic and neural modularity underlie the evolution of schooling behavior in threespine sticklebacks genetics of how and why fish swim in schools research sheds light on complex social behavior determinants mri correlates and prognosis of mild cognitive impairment the rotterdam study dementia risk quadrupled in people with mild cognitive impairment long term impact of mode of delivery on stress urinary incontinence and urgency urinary incontinence a systematic review and meta analysis vaginal delivery doubles the risk of stress incontinence compared to caesarean section increased asthma and respiratory symptoms in children exposed to petrochemical pollution industrial air pollution worse than vehicle exhaust for breathing problems in children mid latitude interhemispheric hydrologic seesaw over the past years identifying opposite patterns of climate change hydrologic seesaw over the past years influenza a virus ns targets the ubiquitin ligase trim to evade recognition by the host viral rna sensor rig i influenza virus evades body s immune response through newly discovered mechanism a cytoplasmic role of wnt catenin transcriptional cofactors in tooth enamel formation genetic defects in tooth enamel conducive to development of cavities dynamical ejecta from precessing neutron star black hole mergers with a hot nuclear theory based equation of state new simulations could help in hunt for massive mergers of neutron stars black holes correlates of intentions to use cannabis among us high school seniors in the case of cannabis legalization prevalence of high school seniors marijuana use is expected to increase with legalization what s in children s backpacks foods brought from home room for improvement in elementary school children s lunches and snacks from home changing patterns of in hospital deaths following implementation of damage control resuscitation practices in us forward military treatment facilities shift in resuscitation practices in military combat hospitals under review meta analysis reveals that seed applied neonicotinoids and pyrethroids have similar negative effects on abundance of arthropod natural enemies common insecticides are riskier than thought to predatory insects the relationship between genetic influences on alcohol dependence and on patterns of alcohol consumption simplifying measures of genetic risk for alcohol dependence adverse effects of aromatase inhibition on the brain and behavior in a non human primate confronting the side effects of a common anti cancer treatment the importance of northern peatland expansion to the late holocene rise of atmospheric methane much of early methane rise can be attributed to spreading of northern peatlands predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment breast cancer tumor response to neoadjuvant chemotherapy measured correcting poland syndrome with a custom made silicone implant implants made by computer aided design provide good results in patients with rare chest muscle deformity modulation of dna repair systems in blind cavefish during evolution in constant darkness clues from a somalian cavefish about modern mammals dark past description of a new genus and new species of a fully arboreal crab decapoda brachyura gecarcinucidae from the western ghats india with notes on the ecologyof arboreal crabs new species of tree living crab found in western ghats assessment of bisphenol a bpa neurotoxicity in vitro with mouse embryonic stem cells stem cells help researchers study the effects of pollution on human health association between lifetime posttraumatic stress disorder and past year alcohol use disorder among american indians alaska natives and non hispanic whites posttraumatic stress and alcohol use disorders hit american indian alaskan native men the hardest enhanced emotional responses during social coordination with a virtual partner virtual partner elicits emotional responses from a human partner in real time climate change could drive marine food web collapse through altered trophic flows and cyanobacterial proliferation climate change drives collapse in marine food webs modeling of crop wild relative species identifies areas globally for in situ conservation first comprehensive network of wild crop species will help breeders tackle food insecurity epithelial tumors originate in tumor hotspots a tissue intrinsic microenvironment fruit flies yield clues on cancerous tumor hotspots symmetry protected topological orders in interacting bosonic systems the phases of matter new system successfully classifies symmetry protected phases vision is highly sensitive to oxygen availability in marine invertebrate larvae low oxygen levels could temporarily blind marine invertebrates not just the booze talking trait aggression and hypermasculinity distinguish perpetrators from victims of male barroom aggression hypermasculinity and trait aggression play a major role in perpetration of aggression in bars study finds community structure of copper supply networks in the prehistoric balkans an independent evaluation of the archaeological record from the th to the th millennium bc algorithms identify the dynamics of prehistoric social networks in the balkans a genetic perspective on the relationship between eudaimonic and hedonic well being discovery of first genetic variants associated with meaning in life temperature variability is integrated by a spatially embedded decision making centre to break dormancy in arabidopsis seeds small group of cells within a plant embryo operate in similar way to the human brain postprandial cardiac autonomic function in prader willi syndrome a new way of looking at prader willi syndrome the value of the untenured forest land rights green labor and forest carbon in the brazilian amazon the carbon offset market leveraging forest carbon s value in the brazilian amazon the crystal structure of the intact e. coli relbe toxin antitoxin complex provides the structural basis for conditional cooperativity x rays reveal the self defence mechanisms of bacteria time varying smoking abstinence predicts lower depressive symptoms following smoking cessation treatment kicking the habit study suggests that quitting smoking improves mood estimated cases of legal blindness and visual impairment avoided using ranibizumab for choroidal neovascularization non hispanic white population in the united states with age related macular degeneration study estimates potential for ranibizumab to prevent blindness from age related macular degeneration impaired interneuron development in a novel model of neonatal brain injury new model mimics persistent interneuron loss seen in prematurity delays in emergency care and mortality during major u.s. marathons people suffering heart attacks near major marathons face grimmer survival odds impact of north carolina s early childhood initiatives on special education placements in third grade early childhood programs found to significantly lower likelihood of special education placements in third grade vaccination of patients with mild and severe asthma with a pandemic h n influenza virus vaccine h n vaccine safe and induces robust immune response in people with asthma quality of care for white and hispanic medicare advantage enrollees in the united states and puerto rico stark medicare advantage disparities present in puerto rico warming reverses top down effects of predators on belowground ecosystem function in arctic tundra warming alters predator prey interactions in the arctic multi isotope analysis reveals that feasts in the stonehenge environs and across wessex drew people and animals from throughout britain prehistoric britons rack up food miles for feasts near stonehenge exonic mosaic mutations contribute risk for autism spectrum disorder new genetic risk factor for developing autism spectrum disorder identified ultrasound guided multilevel paravertebral blocks and total intravenous anesthesia improve the quality of recovery after ambulatory breast tumor resection anesthetic technique improves quality of recovery for women having breast cancer surgery partner violence power and gender differences in south african adolescents hiv sexually transmitted infections risk behaviors. gender differences relationship power could be key in preventing hiv in south african adolescents a conserved glycan in the c domain of hiv envelope acts as a molecular switch to control x utilization by clonal variants with identical v loops changes in hiv genetic code determine severity of disease subconcussive head impact exposure and white matter tract changes over a single season of youth football brain changes seen in youth football players without concussion legislative smoking bans for reducing secondhand smoke exposure smoking prevalence and tobacco consumption tobacco policies smoking bans reduce exposure to secondhand smoke and reduce heart attacks review finds the simple fly larval visual system can process complex images brain may see more than the eyes fruit fly study indicates fungal infection counters insecticide resistance in african malaria mosquitoes fungus enhances susceptibility of resistant malaria mosquito to pesticides measurements of chlorpyrifos levels in forager bees and comparison with levels that disrupt honey bee odor mediated learning under laboratory conditions bees dumb down after ingesting tiny doses of the pesticide chlorpyrifos surgical castration of the male common hippopotamus hippopotamus amphibius birth control at the zoo vets meet the elusive goal of hippo castration recombinant aav mediated best transfer to the retinal pigment epithelium analysis of serotype dependent retinal effects first step taken toward macular dystrophy gene therapy genetic evidence of fragmented populations and inbreeding in the colombian endemic dahl s toad headed turtle mesoclemmys dahli dahl s toad headed turtle threatened by fragmented habitat shrinking populations enhanced detection of cancer biomarkers in blood borne extracellular vesicles using nanodroplets and focused ultrasound making sound waves in the fight against cancer military to civilian translation of battlefield innovations in operative trauma care military data supporting damage control resuscitation has altered civilian practice can drosophila melanogaster tell who s who ? artificial fly brain can tell who s who conformational switching of the pseudokinase domain promotes human mlkl tetramerization and cell death by necroptosis human immune trigger map paves way for better treatments post stroke insomnia in community dwelling patients with chronic motor stroke physiological evidence and implications for stroke care insomnia is a likely long term side effect of stroke study finds earliest and first northern hemispheric hoatzin fossils substantiate old world origin of a neotropic endemic old bird new world did the south american hoatzins originate in europe ? the contribution of outer hi disks to the merging binary black hole population monster colliding black holes might lurk on the edge of spiral galaxies concurrent and prospective analyses of peer television and social media influences on body dissatisfaction eating disorder symptoms and life satisfaction in adolescent girls peer pressure trumps thin ideals in the media regional and seasonal variation in clostridium difficile infections among hospitalized patients in the united states c. difficile rates highest in northeast region of u.s. spring season modification of the effect of vitamin e supplementation on the mortality of male smokers by age and dietary vitamin c vitamin e may decrease mortality of elderly male smokers yet increase mortality of middle aged smokers historical reconstruction reveals recovery in hawaiian coral reefs decline and recovery of coral reefs linked to years of human and environmental activities postural control in bipolar disorder increased sway area and decreased dynamical complexity bipolar disorder and postural control mind body connection suggests new directions for treatment research new aspect of plant rhizobia interaction alkaloid biosynthesis incrotalariadepends on nodulation poisonous symbiosis scientists discover mechanics of poison production in crotalaria inactivating cholecystokinin receptor inhibits progastrin dependent colonic crypt fission proliferation and colorectal cancer in mice the protein cckr a potential drug target for colorectal cancer ? divergent effects of resistance and endurance exercise on plasma bile acids fgf and fgf in humans cardio exercise and strength training affect hormones differently biogenic non crystalline u iv revealed as major component in uranium ore deposits a new twist on uranium s origin story sca derived cells are a source of myocardial renewal in the murine adult heart the heart s own stem cells play their part in regeneration volume and connectivity of the ventral tegmental area are linked to neurocognitive signatures of alzheimer s disease in humans detecting diminished dopamine firing cells inside the brain could reveal earliest signs of alzheimer s disease pediatric adhd medication exposures reported to us poison control centers us poison control centers receive calls per day about children exposed to adhd medications caribbean corals in crisis record thermal stress bleaching and mortality in heat stress to caribbean corals in worst on record caribbean reef ecosystems may not survive repeated stress masculine boys feminine girls and cancer risk behaviors an year longitudinal study masculine boys feminine girls more likely to engage in cancer risk behaviors study finds association between cam type deformities and mri detected structural damage of the hip a cross sectional study in young males cam type deformities linked to mri detected hip damage in asymptomatic young men comparative analysis of the antimicrobial activities of plant defensin like and ultrashort peptides against food spoiling bacteria. plant kingdom provides two new candidates for the war on antibiotic resistance a woman s place is in theatre women s perceptions and experiences of working in surgery from the association of surgeons of great britain and ireland women in surgery working group over half of uk female surgeons have experience of workplace discrimination poll suggests excess digestive capacity in predators reflects a life of feast and famine salmon and other fish predators rely on no guts no glory survival tactic high power prismatic devices for oblique peripheral prisms high power prismatic devices may further expand visual fields for patients with hemianopia review of neopalpa povoln with description of a new species from california and baja california mexico lepidoptera gelechiidae new species of moth named in honor of donald trump ahead of his swearing in as president safety and efficacy of the intravenous infusion of umbilical cord mesenchymal stem cells in patients with heart failure a phase randomized controlled trial rimecard trial umbilical cord stem cells show promise as heart failure treatment long term randomized trial of intensive versus symptomatic management in paget s disease of bone the prism ez study insights on optimal treatment of paget s disease of bone parasite infected sticklebacks increase the risk taking behaviour of uninfected group members sticklebacks infected with parasites influence behavior of healthy fish physiological and behavioural responses of young horses to hot iron branding and microchip implantation branding or microchip implant for identification tradition or stress ? sequential bottlenecks drive viral evolution in early acute hepatitis c virus infection breakthrough opens new avenues for hep c vaccine goffin s cockatoos make the same tool type from different materials skilful cockatoos able to shape same tool from different materials an immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells major breakthrough in the manufacture of red blood cells projected impacts of federal tax policy proposals on mortality burden in the united states a microsimulation analysis new analysis links proposed changes in u.s. tax laws to rich poor gap and deaths among americans brca deficiency exaggerates doxorubicin induced cardiomyocyte apoptosis and cardiac failure breast cancer and heart disease may have common roots improved antitumor activity of immunotherapy with braf and mek inhibitors in brafv e melanoma benefits of immunotherapy cancer targeted treatment in triple combo drug for melanoma chronic fatigue syndrome in an ethnically diverse population the influence of psychosocial adversity and physical inactivity ethnic minorities are silent sufferers of chronic fatigue syndrome the clusters hiding in plain sight chips survey a first discovery of a massive nearby cluster around pks sprawling galaxy cluster found hiding in plain sight reported knee pain prevalence in a community based cohort over years knee pain common complaint in middle aged and mature women trends in depression prevalence in the usa from to widening disparities in vulnerable groups depression is on the rise in the us especially among young teens getting caught with our plants down the risks of a global crop yield slowdown from climate trends in the next two decades climate change increases risk of crop slowdown in next years whole genome sequencing resource identifies new candidate genes for autism spectrum disorder world s largest autism genome database shines new light on many autisms weight history and all cause and cause specific mortality in three prospective cohort studies weight history over time shows higher risk of death for overweight obese people a cryptic sensor for hiv activates antiviral innate immunity in dendritic cells novel sensing mechanism discovered in dendritic cells to increase immune response to hiv vegf and igf delivered from alginate hydrogels promote stable perfusion recovery in ischemic hind limbs of aged mice and young rabbits fresh blood for damaged tissues via alginate hydrogels import volumes and biosecurity interventions shape the arrival rate of fungal pathogens biosecurity reduces invasions of plant pathogens over a national border are the public health responsibility deal alcohol pledges likely to improve public health ? an evidence synthesis public health responsibility deal in uk unlikely to be an effective response to alcohol harms serum omega polyunsaturated fatty acids and risk of incident type diabetes in men the kuopio ischaemic heart disease risk factor study fish derived serum omega fatty acids help reduce risk of type diabetes vinobot and vinoculer two robotic platforms for high throughput field phenotyping fighting world hunger robotics aid in the study of corn and drought tolerance the association between self reported stigma and loss to follow up in treatment eligible hiv positive adults in rural kwazulu natal south africa younger people men those without children more likely to drop out of hiv care in south africa designer nanoscale dna assemblies programmed from the top down automating dna origami opens door to many new uses filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy how parasites react to the mouse immune system may help to shape their control the risks of selective serotonin reuptake inhibitor use in infertile women a review of the impact on fertility pregnancy neonatal health and beyond too much risk associated with ssri usage and pregnancy research suggests discovery of the first germline restricted gene by subtractive transcriptomic analysis in the zebra finch taeniopygia guttata discovery of gene of extra chromosome boosts zebra finch biology sizing up the search for autism spectrum disorder asd risk markers during prenatal and early postnatal life higher risk of autism found in children born at short and long interpregnancy intervals a new species of chameleon sauria chamaeleonidae kinyongia highlights the biological affinities between the southern highlands and eastern arc mountains of tanzania welcome to the world new chameleon emerges from wilds of tanzania surgeon influence on use of needle biopsy in patients with breast cancer a national medicare study needle biopsy underused in breast cancer diagnosis negatively impacting diagnosis and care modulation of camp and ras signaling pathways improves distinct behavioral deficits in a zebrafish model of neurofibromatosis type zebrafish model of a learning and memory disorder shows better way to target treatment the interplay between physical activity and anxiety sensitivity in fearful responding to carbon dioxide challenge people at risk for panic buffered from stressor by high levels of physical activity prenatal organophosphorus pesticide exposure and child neurodevelopment at months an analysis of four birth cohorts fossil fuel combustion endangers children s health in two significant ways scientist reviews the evidence volcanic arcs fed by rapid pulsed fluid flow through subducting slabs like a jet through solid rock volcanic arc fed by rapid fluid pulses soil microbial community responses to a decade of warming as revealed by comparative metagenomics. soil microbes alter dna in response to warming therapeutic effects of magnetic and copper bracelets in osteoarthritis a randomised placebo controlled crossover trial arthritis copper bracelets magnetic wrist straps useless ? trial raises doubts over alternative pain therapy local adaptation constrains the distribution potential of heat tolerant symbiodinium from the persian arabian gulf surviving harsh environments becomes a death trap for specialist corals structural basis for regulation of human calcium sensing receptor by magnesium ions and an unexpected tryptophan derivative co agonist study paves way for new therapies in fight against calcium disorders evidence based evaluation of complementary health approaches for pain management in the united states nondrug approaches effective for treatment of common pain conditions review suggests first dairying in green saharan africa in the fifth millennium bc chemical analysis of pottery reveals first dairying in saharan africa nearly years ago spatial and temporal association of outbreaks of h n influenza virus infection in wild birds with the c isotherm cold fronts linked to european h n outbreaks an ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion digestive ability of ancient insects could boost biofuel development box based temporal decomposition of multi period economic dispatch for two stage robust unit commitment planning ahead a new robust approach for minimizing costs in power distribution networks ocean solutions to address climate change and its effects on marine ecosystems climate change efforts should focus on ocean based solutions unhealthy behaviours and disability in older adults three city dijon cohort study physical inactivity poor diet and smoking linked to disability in older population health and climate change policy responses to protect public health climate change threatens to undermine the last half century of health gains cost effectiveness of antenatal corticosteroid therapy vs no therapy in women at risk of late preterm delivery lower costs associated with late preterm steroid therapy the health effects of fetal microchimerism can be modeled in companion dogs older siblings cells can be passed from female dogs to their puppies in the womb cardiovascular disease risk in women with a history of spontaneous preterm delivery a systematic review and meta analysis women with a pregnancy history of spontaneous preterm delivery found at higher risk of cardiovascular diseases arabidopsis kelch repeat f box proteins regulate phenylpropanoid biosynthesis via controlling the turnover of phenylalanine ammonia lyase enlisting cells protein recycling machinery to regulate plant products quantifying hormone disruptors with an engineered bacterial biosensor using e. coli to detect hormone disruptors in the environment inhibitory neuron transplantation into adult visual cortex creates a new critical period that rescues impaired vision neurobiologists restore youthful vigor to adult mouse brains risk of colorectal cancer among long term cervical cancer survivors radiation therapy for cervical cancer increases risk for colorectal cancer a folding switch regulates interleukin biogenesis and secretion of its subunit as a cytokine protein engineering extends the language of immune cells pressure flaking to serrate bifacial points for the hunt during the mis at sibudu cave south africa early evidence of middle stone age projectiles found in south africa s sibudu cave erosive rheumatoid arthritis is associated with antibodies that activate pad by increasing calcium sensitivity enzyme activating antibodies revealed as marker for most severe form of rheumatoid arthritis cd and cd mark human intestinal epithelial cell populations with characteristics of active and facultative stem cells adult stem cells isolated from human intestinal tissue ccl promotes breast cancer recurrence through macrophage recruitment in residual tumors study in mice uncovers an unknown pathway for breast cancer tumors to recur an antifungal polyketide associated with horizontally acquired genes supports symbiont mediated defense in lagria villosa beetles lateral gene transfer enables chemical protection of beetles against antagonistic fungi native ladybird decline caused by the invasive harlequin ladybird harmonia axyridis evidence from a long term field study invasive ladybird species threatens other ladybirds in england gon l drives cancer growth through a yy androgen receptor cd axis new technique sorts drivers from passengers in cancer genomics implicates gon l unhealthy weight management practices and non medical use of prescription drugs unhealthy weight management practices associated with non medical use of prescription drugs among adolescents cryptic species diversity reveals biogeographic support for the mountain passes are higher in the tropics hypothesis for tropical mayflies mountain passes are higher indeed antibiotic and pesticide susceptibility and the anthropocene operating space planetary boundaries for antibiotic and pesticide resistance identified functional diversity in cover crop polycultures increases multifunctionality of an agricultural system cover crop mixtures increase agroecosystem services first of kind study suggests dental calculus as a source of ancient alkaloids detection of nicotine by lc ms in calculus samples from the americas nicotine extracted from ancient dental plaque for the first time synergistic effects of non apis bees and honey bees for pollination services two new studies show why biodiversity is important for pollination services in california almond climate change may cause severe loss in the economic value of european forest land severe economic loss for european forest land expected by mixed infections and in vivo evolution in the human fungal pathogen cryptococcus neoformans unexpectedly high rate of multiple strains in fungal infection dna demethylase activity maintains intestinal cells in an undifferentiated state following loss of apc mechanism behind demethylation pinpointed in apc gene mutants stratifying risk of urinary tract malignant tumors in patients with asymptomatic microscopic hematuria microscopic blood in urine unreliable indicator of urinary tract cancer intranasal administration of the tlr agonist pam cys provides rapid protection against influenza in mice an advance toward a flu fighting nasal spray cortico fugal output from visual cortex promotes plasticity of innate motor behavior visual cortex plays role in plasticity of eye movement reflex bed sharing when parents do not smoke is there a risk of sids ? an individual level analysis of five major case control studies bed sharing leads to fivefold increase in risk of crib death for babies whose parents do not smoke problematic drinking mediates the association between urgency and intimate partner aggression during acute intoxication intoxication increases risk for heavy drinkers to commit violence against intimate partner mcur is a scaffold factor for the mcu complex function and promotes mitochondrial bioenergetics scientists identify key factor in mitochondrial calcium uptake and bioenergetics the cost effectiveness and budgetary impact of a dolutegravir based regimen as first line treatment of hiv infection in india state of the art hiv drug could curb hiv transmission improve survival in india exosomal microrna predicts and protects against severe bronchopulmonary dysplasia in extremely premature infants microrna predicts and protects against severe lung disease in extremely premature infants teaching young children a theory of nutrition conceptual change and the potential for increased vegetable consumption getting kids to eat their veggies a new approach to an age old problem the long noncoding rna chaer defines an epigenetic checkpoint in cardiac hypertrophy biological dark matter molecule plays surprise role in heart failure national performance benchmarks for modern screening digital mammography update from the breast cancer surveillance consortium mammography trends show improved cancer detection more biopsies everolimus eluting stents or bypass surgery for multivessel coronary disease no mortality benefit of bypass surgery compared to latest generation of drug coated stents vaccine elicited cd t cells induce immunopathology after chronic lcmv infection vaccine inducedcd t cells lead to adverse effect in a mouse model of infection proximity based differential single cell analysis of the niche to identify stem progenitor cell regulators researchers find new functions of blood cell protein in transplant plague outbreaks in prairie dog populations explained by percolation thresholds of alternate host abundance carnivorous mice spread deadly plague in prairie dog towns study finds effects of statewide job losses on adolescent suicide related behaviors mass layoffs linked to increased teen suicide attempts host persistence or extinction from emerging infectious disease insights from white nose syndrome in endemic and invading regions bats in asia found to have resistance to white nose syndrome fungus iron promotes protein insolubility and aging in c. elegans when heavy metals go off kilter study in c. elegans shows excess iron promotes aging loss of function mutations in the rna biogenesis factor naf predispose to pulmonary fibrosis emphysema new disease gene linked to telomerase abnormalities in some cases of pulmonary fibrosis emphysema oxygen cost of exercise hyperpnoea is greater in women compared with men oxygen uptake in respiratory muscles differs between men and women during exercise linked dimensions of psychopathology and connectivity in functional brain networks machine learning links dimensions of mental illness to abnormalities of brain networks scaling up analogical innovation with crowds and ai scaling up search for analogies could be key to innovation children s recall of fast food television advertising testing the adequacy of food marketing regulation fast food commercials to kids deceptive by industry self regulation standards healthy lifestyle change and subclinical atherosclerosis in young adults coronary artery risk development in young adults cardia study adults can undo heart disease risk by changing lifestyle filaggrin variation is associated with more persistent atopic dermatitis in african american subjects first genetic mutations linked to atopic dermatitis identified in african american children prevalence of nonrecommended screening for prostate cancer and breast cancer in the united states nonrecommended screenings for prostate breast cancer in older individuals transient membrane localization of spv drives cyclical actomyosin contractions in the c. elegans spermatheca epithelial tube contraction a new feedback mechanism for regulating contractility rheumatoid arthritis increases the risk of deep vein thrombosis and pulmonary thromboembolism a nationwide cohort study rheumatoid arthritis heightens risk of dangerous leg and lung blood clots closing the gap increases in life expectancy among treated hiv positive individuals in the united states and canada life expectancy increases among treated hiv positive individuals in us canada decreased management of genital warts in young women in australian general practice post introduction of national hpv vaccination program results from a nationally representative cross sectional general practice study percent fall in female genital warts due to free hpv vaccine enabling autologous human liver regeneration with differentiated adipocyte stem cells researchers demonstrate efficient method for converting fat cells to liver cells the greenland ice sheet as a hotspot of phosphorus weathering and export in the arctic greenland ice sheet releasing mississippi river worth of phosphorus always chew your food freshwater stingrays use mastication to process tough insect prey freshwater stingrays chew their food just like a goat hydrogen production by tuning the photonic band gap with the electronic band gap of tio researchers design new catalyst to produce hydrogen from water sunlight investigating the impact of feedback update interval on the efficacy of restorative brain computer interfaces stroke patient improvement with a brain computer interface macrophage released pyrimidines inhibit gemcitabine therapy in pancreatic cancer tumor associated immune cells hinder frontline chemotherapy drug in pancreatic cancer negative regulation of peptidyl prolyl isomerase activity by interdomain contact in human pin study reveals insights into protein linked to cancer alzheimer s disease a novel landscape genetic approach demonstrates the effects of human disturbance on the udzungwa red colobus monkey procolobus gordonorum genetic differences among monkeys in tanzania show troubling pattern discovery of a time lag between the soft x ray and radio emission of the tidal disruption flare asassn li evidence for linear disk jet coupling scientists detect radio echoes of a black hole feeding on a star effect of oral capsule vs colonoscopy delivered fecal microbiota transplantation on recurrent clostridium difficile infection poop pill capsule research paves the way for simpler c. difficile treatment return on investment for open source scientific hardware development making a difference with open source science equipment school counselors multiple student deaths and grief a narrative inquiry school counselors reflect on their experience following student deaths genetic association of recovery from eating disorders the role of gaba receptor snps new study sheds light on role of genetics in recovering from eating disorders the dopaminergic reward system underpins gender differences in social preferences the female brain reacts more strongly to prosocial behavior than the male brain study finds long term outcome of early interventions to prevent posttraumatic stress disorder early treatment for post traumatic stress disorder accelerates recovery but does not sustain it death associated protein kinase promotes growth of p mutant cancers death associated protein promotes cancer growth in most aggressive breast cancers loneliness anxiousness and substance use as predictors of facebook use alcohol use anxiety predict facebook use by college students characterization and correction of olfactory deficits in kidney disease sense of smell deficits are common linked to malnutrition in patients with kidney disease astrocyte secreted chordin like drives synapse maturation and limits plasticity by increasing synaptic glua ampa receptors brain cells called astrocytes have unexpected role in brain plasticity screening of immigrants in the uk for imported latent tuberculosis a multicentre cohort study and cost effectiveness analysis uk immigrant screening misses majority of imported latent tb finds study effect of oral prednisolone on symptom duration and severity in nonasthmatic adults with acute lower respiratory tract infection a randomized clinical trial steroids not effective for chest infections in non asthmatic adults national survey of united states human immunodeficiency virus medical providers knowledge and attitudes about the affordable care act affordable care act study finds surprising gaps in hiv care providers knowledge a feedback neural circuit for calibrating aversive memory strength the power of expectation can restrain hyper emotional memories in the brain tumor evolution of glioma intrinsic gene expression subtype associates with immunological changes in the microenvironment glioblastoma ecosystem redefined for more effective immunotherapy trials identification of per and polyfluoroalkyl substances in the cape fear river by high resolution mass spectrometry and nontargeted screening new pfass discovered in cape fear river north carolina though levels are declining imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of bacillus subtilis imaging reveals key metabolic factors of cannibalistic bacteria pharmacokinetics of lopinavir ritonavir and efavirenz in food insecure hiv infected pregnant and breastfeeding women in tororo uganda malnutrition decreases effectiveness of hiv treatment in pregnant african women enrichment of tomato fruit with health promoting anthocyanins by expression of select transcription factors purple tomatoes rich in health protecting anthocyanins developed with help of snapdragons time restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high fat diet extended daily fasting overrides harmful effects of a high fat diet study may offer drug free intervention to prevent obesity and diabetes mmej assisted gene knock in using talens and crispr cas with the pitch systems an alternative talen crispr mediated gene insertion technique described in detail clinical practice guideline improving nasal form and function after rhinoplasty experts develop evidence based clinical practice guideline on rhinoplasty does mother know best ? an actor partner model of college age women s human papillomavirus vaccination behavior mothers key to college age women receiving hpv vaccine study suggests protective efficacy and long term immunogenicity in cynomolgus macaques by ebola virus glycoprotein synthetic dna vaccines dna vaccine against ebola virus shows potent and long term efficacy in preclinical studies preserving species populations in the boreal zone in a changing climate contrasting trends of bird species groups in a protected area network boreal bird species of conservation concern affected by climate change single cell rna sequencing identifies a metabolic aspect of apoptosis in rbf mutant single cell sequencing sheds light on why cancers form in specific cell types measuring the quality of inclusive practices findings from the inclusive classroom profile pilot new study points to better classrooms for children with disabilities ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis huntington s disease gene dispensable in adult mice sexual orientation disparities in cancer related risk behaviors of tobacco alcohol sexual behaviors and diet and physical activity pooled youth risk behavior surveys lgbt youth face greater cancer risks study shows nucleus targeted organoiridium albumin conjugate for photodynamic cancer therapy simply shining light on dinosaur metal compound kills cancer cells coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism study pinpoints cell type brain region affected by gene mutations in autism stepwise evolution of paleozoic tracheophytes from south china contrasting leaf disparity and taxic diversity exploring the deep time roots of plant diversity remission of human type diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for cell recovery why weight loss produces remission of type diabetes in some patients therapeutic exploitation of ipse a urogenital parasite derived host modulatory protein for chemotherapy induced hemorrhagic cystitis protein derived from parasite has potential to alleviate debilitating disease potential strong contribution of future anthropogenic land use and land cover change to the terrestrial carbon cycle expansion of agricultural land reduces carbon dioxide absorption school bullying perpetration and other childhood risk factors as predictors of adult intimate partner violence perpetration study suggests link between childhood bullying and adult intimate partner violence perpetration prevalence of chagas disease in the latin american born population of los angeles first large scale survey of chagas disease in the united states confirms that the silent killer is a major public health challenge for the country drosophila iap antagonists form multimeric complexes to promote cell death reaper protein strikes at mitochondria to kill cells circulating avian influenza viruses closely related to the virus have pandemic potential genes found in nature yield like virus with pandemic potential newborn hearing screening vs later hearing screening and developmental outcomes in children with permanent childhood hearing impairment newborn hearing screening linked with improved developmental outcomes for hearing impaired children two billion year old evaporites capture earth s great oxidation two billion year old salt rock reveals rise of oxygen in ancient atmosphere excessive burden of lysosomal storage disorder gene variants in parkinson s disease defects in cell s waste disposal system linked to parkinson s nonlegumes respond to rhizobial nod factors by suppressing the innate immune response first step to reduce plant need for nitrogen fertilizer uncovered blood lead levels of children in flint michigan blood lead levels of flint children before and after water crisis micu regulation of mitochondrial ca uptake dictates survival and tissue regeneration stress pushes cells to die when gatekeeper of calcium use in mitochondria is dysfunctional drug companies should be held more accountable for their human rights responsibilities pharma must be held more accountable to its human rights responsibilities editors argue does continued participation in stem enrichment and enhancement activities affect school maths attainment ? stem enrichment activities have no impact on exam results developmental trajectories of symptom severity and adaptive functioning in an inception cohort of preschool children with autism spectrum disorder diversity in developmental trajectories in kids with autism spectrum disorder the evolutionary dynamics of the lion panthera leo revealed by host and viral population genomics unraveling lion s natural history using host and virus population genomics fe and fe l amyloid precursor protein binding protein compound null mice display adult onset cataract and muscle weakness alzheimer s protein plays role in maintaining eye health muscle strength a new subspecies of sea snake hydrophis platurus xanthos from golfo dulce costa rica the new yellow sea snake assumes an unusual ambush posture direct and long term detection of gene doping in conventional blood samples gene doping detectable with a simple blood test hummingbirds and bumble bees exposed to neonicotinoid and organophosphate insecticides in the fraser valley british columbia canada exposure of hummingbirds and bumble bees to pesticides targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice novel therapy inhibits complement to preserve neurons and reduce inflammation after stroke predation by cats could lead to the extinction of the mediterranean endemic yelkouan shearwater puffinus yelkouan at a major breeding site invasion of feral cats could see the end of a seabird endemic to the mediterranean prescribing exercise interventions for patients with chronic conditions how to guide to prescribing exercise for chronic health conditions selection free genome editing of the sickle mutation in human adult hematopoietic stem progenitor cells genome engineering paves way for sickle cell cure somatic increase of cct mimics proteostasis of human pluripotent stem cells and extends c. elegans lifespan defining immortality of stem cells to identify novel anti aging mechanisms kdm inhibition targets breast cancer stem like cells new inhibitor brings new hope for aggressive triple receptor negative breast cancer non native plants add to the british flora without negative consequences for native diversity non native plants are not a threat to floral diversity associations of map k gene variants with superior memory in superagers study of superagers offers genetic clues to performance long term effects on luminal and mucosal microbiota and commonly acquired taxa in faecal microbiota transplantation for recurrent clostridium difficile infection healing effect of fecal microbiota transplantation lasts for a long time plant soil feedbacks and the partial recovery of soil spatial patterns on abandoned well pads in a sagebrush shrubland sagebrush ecosystem recovery hobbled by loss of soil complexity at development sites land subsidence in houston correlated with flooding from hurricane harvey hurricane harvey provides lessons learned for flood resiliency plans impacts of climate change on electric power supply in the western united states us west s power grid must be prepared for impacts of climate change high ambient temperature dampens adaptive immune responses to influenza a virus infection heat waves food insecurity due to climate change may weaken immune systems shareholder perceptions of the changing impact of ceos market reactions to unexpected ceo deaths market reactions to sudden ceo deaths highlight ceos importance medicaid expansion in did not increase emergency department use but did change insurance payer mix medicaid expansion did not increase emergency department use comparative effectiveness of high dose versus standard dose influenza vaccination on numbers of us nursing home residents admitted to hospital a cluster randomised trial high dose flu vaccine reduces hospital visits for nursing home residents two pore channels control ebola virus host cell entry and are drug targets for disease treatment asian herb holds promise as treatment for ebola virus disease manual therapy physical therapy or continued care by the general practitioner for patients with neck pain physical therapy offers evidence based solution to musculoskeletal pain epidural glucocorticoid injections for spinal stenosis interlaminal at the worst level researchers show effectiveness of non surgical treatment of lumbar spinal stenosis value of iga ttg in predicting mucosal recovery in children with celiac disease on a gluten free diet twenty percent of children with celiac disease do not heal on a gluten free diet trace elements in natural azurite pigments found in illuminated manuscript leaves investigated by synchrotron x ray fluorescence and diffraction mapping x ray finds unique fingerprint in medieval manuscript ink multivariate connectome based symptom mapping in post stroke patients networks supporting language and speech predicting language deficits after stroke with connectome based imaging supershear rupture in a mw. aftershock of the sea of okhotsk earthquake evidence of super fast deep earthquake rare high speed rupture off russia and similar phenomena on shallow fault zones a longitudinal study of estrogen responsive tissues and hormone concentrations in infants fed soy formula babies fed soy based formula have changes in reproductive system tissues rapid label free detection of brain tumors with stimulated raman scattering microscopy new laser based tool could dramatically improve the accuracy of brain tumor surgery experimental habitat fragmentation disrupts nematode infections in australian skinks forest fragmentation disrupts parasite infection in australian lizards direct detection of cancer biomarkers in blood using a place n play modular polydimethylsiloxane pump catching cancer early by chasing it portable diagnostic device that can travel to the patient abundance and distribution of microplastics within surface sediments of a key shellfish growing region of canada microplastics may be abundant in the surface sediments of baynes sound and lambert channel h s production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea study suggests ways to block hypertension in those with sleep apnea cryptococcus neoformans copper detoxification machinery is critical for fungal virulence fungus uses copper detoxification as crafty defense mechanism the effects of uv emission from cfl exposure on human dermal fibroblasts and keratinocytes in vitro. harmful effects of cfl bulbs to skin energy efficient bulbs safest when placed behind additional glass cover aripiprazole in the maintenance treatment of bipolar disorder a critical review of the evidence and its dissemination into the scientific literature limitations of evidence base for prescribing aripiprazole in maintenance therapy of bipolar disorder hiv diagnoses prevalence and outcomes in nine southern states hiv aids patients in deep south of u.s. have lower survival rates cytoplasmic rbfox regulates the expression of synaptic and autism related genes untapped region in brain cell offers goldmine of drug targets for new autism treatments spaced training rescues memory and erk signaling in fragile x syndrome model mice multiple short learning sessions strengthen memory formation in fragile x syndrome phosphorus not nitrogen limits plants and microbial primary producers following glacial retreat phosphorus nutrition can hasten plant and microbe growth in arid high elevation sites homogenization of lake cyanobacterial communities over a century of climate change and eutrophication cyanobacteria in lakes risks linked to loss of diversity impact of eischens yoga during radiation therapy on prostate cancer patient symptoms and quality of life a randomized phase ii trial clinical trial shows benefit of yoga for side effects of prostate cancer treatment the effect of u.s. university students problematic internet use on family relationships a mixed methods investigation college students internet overuse leads families to connect and conflict new study finds amygdala volume changes in posttraumatic stress disorder in a large case controlled veterans group ptsd linked to smaller brain area regulating fear response do celebrity cancer diagnoses promote primary cancer prevention ? can celebrity cancer diagnoses prompt quitting smoking ? state level variation in the relationship between child removals and opioid prescriptions impact of opioid epidemic on children varies by state targeted cytotoxic therapy kills persisting hiv infected cells during art research demonstrates guided missile strategy to kill hidden hiv age matters pheromone profiles of larvae differentially influence foraging behaviour in the honeybee apis mellifera age matters young larvae boost pollen foraging in honey bees blue light activated nano tio pda for highly effective and nondestructive tooth whitening a safe and effective way to whiten teeth structure based design of a fusion glycoprotein vaccine for respiratory syncytial virus scientists develop candidate vaccine against respiratory syncytial virus objective risk stratification of prostate cancer using machine learning and radiomics applied to multiparametric magnetic resonance images researchers develop prostate cancer prediction tool that has unmatched accuracy spatial transmission of pandemic influenza in the us new analysis of swine flu pandemic conflicts with accepted views on how diseases spread cross linguistic data formats advancing data sharing and re use in comparative linguistics guidelines for a standardized data format for use in cross linguistic studies nerve transfers for enterovirus d associated acute flaccid myelitis a case series pioneering surgery restores movement to children paralyzed by acute flaccid myelitis a cost effectiveness analysis of human papillomavirus vaccination of boys for the prevention of oropharyngeal cancer hpv vaccination of adolescent boys may be cost effective for preventing oropharyngeal cancer alcohol consumption left atrial diameter and atrial fibrillation moderate alcohol use linked to heart chamber damage atrial fibrillation in new study using conditional probability to identify trends in intra day high frequency equity pricing stock price movements are predictable during a short window advanced geometrical constructs in a pueblo ceremonial site c ce advanced geometry no secret to prehistoric architects in us southwest prospective longitudinal ctdna workflow reveals clinically actionable alterations in ovarian cancer circulating tumor dna gives treatment options for the most common ovarian cancer type assessing the discordance rate between local and central her testing in women with locally determined her negative breast cancer false negative results found in prognostic testing for breast cancer opioid treatment at release from jail using extended release naltrexone a pilot proof of concept randomized effectiveness trial opioid relapse rates fall after jail release according to pilot study subcas a portable submersible hyperbaric chamber to collect living mesophotic fishes new invention safely transports unknown deep dwelling fishes to the ocean s surface carrying capacity of u.s. agricultural land ten diet scenarios u. s. land capacity for feeding people could expand with dietary changes nephron organoids derived from human pluripotent stem cells model kidney development and injury investigators create complex kidney structures from human stem cells derived from adults towards non invasive diagnostic imaging of early stage alzheimer s disease new non invasive method can detect alzheimer s disease early the relationship among oceanography prey fields and beaked whale foraging habitat in the tongue of the ocean identifying beaked whale foraging habitat in the bahamas early impact of the affordable care act on oral contraceptive cost sharing discontinuation and nonadherence early impact of the affordable care act on oral contraceptive cost sharing comparison of stepped care delivery against a single empirically validated cognitive behavioral therapy program for youth with anxiety a randomized clinical trial a new model of treatment for youth with anxiety recurrent specialization on a toxic fruit in an island drosophila population recent evolutionary change allows a fruit fly to dine on a toxic fruit declines in large wildlife increase landscape level prevalence of rodent borne disease in africa declines in large wildlife lead to increases in disease risk reconciling conflicting phylogenies in the origin of sweet potato and dispersal to polynesia sweet potato history casts doubt on early contact between polynesia and the americas proof of concept randomized controlled clinical trial of bacillus calmette guerin for treatment of long term type diabetes clinical trial results support strategy for reversing type diabetes treatment with generic vaccine kills autoimmune cells temporarily restoring insulin production adjuvant ipilimumab versus placebo after complete resection of high risk stage iii melanoma eortc a randomised double blind phase trial adjuvant ipilimumab effects survival after high risk lymph node and melanoma resection optical fiber driven low energy electron gun for ultrafast streak diffraction ultrafast optical fiber based electron gun to reveal atomic motions temperature decouples ammonium and nitrite oxidation in coastal waters rising water temperatures endanger health of coastal ecosystems study finds race influences parent report of concerns about symptoms of autism spectrum disorder parents reports of children s autism symptoms differ by ethnicity essential role for zinc transporter znt mediated zinc transport in mammary gland development and function during lactation mutation in zinc transport protein may inhibit successful breastfeeding the effects of large beach debris on nesting sea turtles more sea turtles survive with less beach debris microrna profiling of low grade glial and glioneuronal tumors shows an independent role for cluster q. member mir b researchers uncover more genetic links to brain cancer cell growth neratinib plus paclitaxel vs trastuzumab plus paclitaxel in previously untreated metastatic erbb positive breast cancer neratinib plus paclitaxel vs. trastuzumab plus paclitaxel in breast cancer mutations associated with acquired resistance to pd blockade in melanoma study unlocks key mechanisms that determine acquired resistance to immunotherapy in advanced melanoma effects of autism spectrum disorder insurance mandates on the treated prevalence of autism spectrum disorder insurance mandates lead to more children diagnosed and treated for autism spectrum disorder suicidal germination as a control strategy for striga hermonthica benth. in smallholder farms of sub saharan africa harnessing plant hormones for food security in africa heavy snoring as a cause of carotid atherosclerosis heavy snoring is an independent risk factor for carotid atherosclerosis circadian disrupting exposures and breast cancer risk a meta analysis artificial light biological clock disruptions increase breast cancer risk study finds disentangling prenatal and inherited influences in humans with an experimental design researchers investigate prenatal smoking link with antisocial behavior in children cellular defense against latent colonization foiled by human cytomegalovirus ul protein how cells are foiled by a herpesvirus family member in the virus host arms race was frozen mammoth or giant ground sloth served for dinner at the explorers club ? prehistoric mystery meat put to the test spoiler alert it s not woolly mammoth or giant ground sloth water quality mediates resilience on the great barrier reef no silver bullet for helping the great barrier reef disparities in ovarian cancer survival in the united states findings from the concord study racial disparities persist in the survival of patients with ovarian colon and breast cancer the impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development childhood coxsackie virus infection depletes cardiac stem cells might compromise heart health in adults racial disparities in posttraumatic stress after diagnosis of localized breast cancer the bqual study nearly in women with breast cancer report ptsd symptoms study finds cytochrome p e cyp e regulates the response to oxidative stress and migration of breast cancer cells alcohol breakdown molecule may play a role in breast cancer development effect of a serogroup a meningococcal conjugate vaccine psa tt on serogroup a meningococcal meningitis and carriage in chad a community trial meningitis a mass vaccination campaign shows dramatic impact of new vaccine dealing with urban noise vermilion flycatchers sing longer songs in noisier territories urban noise makes flycatchers change length of their songs desert mammal populations are limited by introduced predators rather than future climate change feral animals pose major threat to outback climate change study finds dynamic changes in dna methylation of stress associated genes oxtr bdnf after acute psychosocial stress acute stress alters control of gene activity researchers examine dna methylation a high throughput platform for stem cell niche co cultures and downstream gene expression analysis a single cell breakthrough newly developed technology dissects properties of single stem cells tinamous and moa flock together mitochondrial genome sequence analysis reveals independent losses of flight among ratites dinosaur extinction grounded ancient birds new research finds characterization of biodegradation in a th century easel painting and potential for a biological approach a detailed look at the microorganisms that colonize and degrade a year old painting mapping cultural ecosystem services. potential and shortcomings from unlabeled crowd sourced images photos in social media reveal socio cultural value of landscapes better safe than sorry ? the safety margin surrounding the body is increased by anxiety size of personal space is affected by anxiety phycomyces madb interacts with mada to form the primary photoreceptor complex for fungal phototropism molecular complex essential for vision identified in fungi human population density and growth validated as extinction threats to mammal and bird species outlook is grim for mammals and birds as human population grows dysphagia and disrupted cranial nerve development in a mouse model of digeorge q deletion syndrome potential solution for feeding swallowing difficulties in children with digeorge syndrome autism oxidized ldl and fructosamine associated with severity of coronary artery atherosclerosis in insulin resistant pigs fed a high fat high nacl diet two biomarkers linked to severe heart disease found atrial fibrillation and risk of st segment elevation versus non st segment elevation myocardial infarction the atherosclerosis risk in communities aric study atrial fibrillation increases risk of only one type of heart attack weight loss following diet induced obesity does not alter colon tumorigenesis in the aom mouse model weight loss after obesity doesn t cut risk of certain types of cancer uv protection timer controls linkage between stress and pigmentation skin protection systems mouse and human skin cells produce melanin on a hour cycle production of biologically active recombinant human factor h in physcomitrella medicine from moss bioreactor technique may offer hope to people with age related blindness green banana pasta an alternative for gluten free diets pasta made from green banana flour a tasty alternative for gluten free diets serial magnetic resonance imaging to identify early stages of anthracycline induced cardiotoxicity very early marker of cardiac damage triggered by cancer treatment tandem luminescent solar concentrators based on engineered quantum dots tweaking quantum dots powers up double pane solar windows dopaminergic reward signals selectively decrease fmri activity in primate visual cortex pavlov inverted reward linked to image is enough to activate brain s visual cortex the meaning and predictive value of self rated mental health among persons with a mental health problem self rating mental health as good predicts positive future mental health ws nanotubes d nanomeshes and d in plane films through one single chemical vapor deposition route new tunable nanomaterials possible due to flexible process invented by physicists a comparison of methods to assess cell mechanical properties the force is strong within us new study explores cell mechanics at work apolipoprotein a iv binds iib integrin and inhibits thrombosis how olive oil and sleep could stave off heart attacks and strokes new study examines plasma protein s role evolutionarily assembled cis regulatory module at a human ciliopathy locus scientists link evolved mutated gene module to syndromic autism comparative efficacy and tolerability of medications for attention deficit hyperactivity disorder in children adolescents and adults a systematic review and network meta analysis adhd medications of all available drugs methylphenidate should be first option for short term treatment in children a new species ofsinophasmag nther from guangxi china phasmida diapheromeridae necrosciinae a master of disguise a new stick insect species from china polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes prenatal lack of omega and omega fatty acids linked to schizophrenic symptoms in mice tim regulates cd dendritic cell function and response to chemotherapy in breast cancer new approach to stimulate an immune response against tumor cells packed and fluidized bed absorber modeling for carbon capture with micro encapsulated sodium carbonate solution professor models system using baking soda filled capsules to capture co emissions whole cell patch clamp measurements of spermatozoa reveal an alkaline activated ca channel capturing the electrical activity of sperm experiments pin down target for a male contraceptive delirium after elective surgery among elderly patients taking statins statins increase risk of postoperative delirium in elderly patients study suggests being bullied during childhood and the prospective pathways to self harm in late adolescence childhood bullying increases the propensity to self harm during adolescence study finds preoperative genetic testing affects surgical decision making in breast cancer patients brca test results affect patients breast cancer surgery plans elesclomol restores mitochondrial function in genetic models of copper deficiency scientists discover potential therapy for human copper metabolism disorders using mathematical programming to select and seed teams for the ncaa tournament new study takes the guesswork out of selecting and seeding teams for march madness design of optimal nonlinear network controllers for alzheimer s disease new computational tool could help optimize treatment of alzheimer s disease activation of nrf in keratinocytes causes chloracne madish like skin disease in mice new surprising link between chloracne and molecule that protects cells against stress novel and ultra rare damaging variants in neuropeptide signaling are associated with disordered eating behaviors new ultra rare gene mutations implicated in eating disorders estrogens suppress a behavioral phenotype in zebrafish mutants of the autism risk gene cntnap estrogens alleviate hyperactivity in zebrafish with autism gene task specific somatosensory feedback via cortical stimulation in humans brain surface stimulation provides touch feedback to direct movement levels of immunity parameters underpin bleaching and disease susceptibility of reef corals after the oil spill new research sheds light on coral susceptibility to environmental stress cultural influences on children s understanding of the human body and the concept of life education culture affect children s understanding of human body remodeling of the mononuclear phagocyte network underlies chronic inflammation and disease progression in heart failure critical importance of the cardiosplenic axis resolvin d reduces post heart attack heart failure a critical role for lta h in limiting chronic pulmonary neutrophilic inflammation protecting the lungs against collateral damage from the immune system contrasting evolutionary history anthropogenic declines and genetic contact in the northern and southern white rhinoceros ceratotherium simum new hope for world s most endangered mammal signature of ocean warming in global fisheries catch fish thermometer reveals long standing global impact of climate change the social bayesian brain does mentalizing make a difference when we learn ? the social brain does guessing others intentions make a difference when we learn ? anomalous brain development is evident in preschoolers with attention deficit hyperactivity disorder younger aged children with symptoms of adhd have reduced brain size assessing recent declines in upper rio grande river runoff efficiency from a paleoclimate perspective warmer temperatures cause decline in key runoff measure self motion perception in autism is compromised by visual noise but integrated optimally across multiple senses neuroscientists reveals autism s noisy secret d simulator reveals inner workings of the autistic brain microrna and the srebp host genes cooperate to control cholesterol homeostasis potential new strategy for raising good cholesterol levels microrna and host gene play key role effect of radiotherapy after mastectomy and axillary surgery on year recurrence and year breast cancer mortality meta analysis of individual patient data for women in randomised trials radiotherapy after mastectomy benefits women with breast cancer that has spread to just a few lymph nodes association of traumatic brain injury with late life neurodegenerative conditions and neuropathologic findings link found between traumatic brain injury and parkinson s but not alzheimer s a non cell autonomous role of bec becn beclin in coordinating cell cycle progression and stem cell proliferation during germline development scientists describe a function for autophagy in germline stem cell proliferation apoglobin stability is the major factor governing both cell free andin vivoexpression of holomyoglobin deep diving whales could hold answer for synthetic blood timed high fat diet resets circadian metabolism and prevents obesity a carefully scheduled high fat diet resets metabolism and prevents obesity researchers find drosophila vision depends on carcinine uptake by an organic cation transporter organic cation transporter cart crucial for drosophila vision clinically relevant changes in family history of cancer over time updating family history of cancer associated with need for earlier or more intense cancer screening study finds examining the reversibility of long term behavioral disruptions in progeny of maternal ssri exposure assessing antidepressant exposure during pregnancy and autism like behavior in mouse pups in the endemic setting clostridium difficile ribotype is virulent but not hypervirulent multiple strains of c. difficile cause severe patient outcomes limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells generating potentially safer stem cells in the laboratory prevalence of the metabolic syndrome in psoriasis results from the national health and nutrition examination survey features of the metabolic syndrome common in persons with psoriasis pathophysiology in mountain yellow legged frogs rana muscosa during a chytridiomycosis outbreak deadly frog fungus at work in the wild evaluating shared decision making for lung cancer screening doctor patient discussions neglect potential harms of lung cancer screening study finds phenotype flexibility in wild fish dolly varden regulate assimilative capacity to capitalize on annual pulsed subsidies some alaskan trout use flexible guts for the ultimate binge diet wrapping it up in a person examining employment and earnings outcomes for ph.d. recipients public and private investments in ph.d. research programs pay economic development dividends class iia hdac inhibition reduces breast tumours and metastases through anti tumour macrophages novel compound that engages second arm of immune system reduces breast tumors metastases mobile phone use and risk of uveal melanoma results of the risk factors for uveal melanoma case control study mobile phone use not associated with melanoma of the eye west nile virus prevalence across landscapes is mediated by local effects of agriculture on vector and host communities west nile virus spreading due to mosquitoes in orchards and vineyards experts warn tnfr dependent cell death drives inflammation insharpin deficient mice inflammatory discovery sheds new light on skin disease implementing a quality by design approach to assure the safety and integrity of botanical dietary supplements ensuring high quality dietary supplements with quality by design outcomes of a comprehensive nonsurgical approach to pelvic floor regabilitation for urinary symptoms defecatory dysfunction and pelvic pain comprehensive nonsurgical treatment improves pelvic floor dysfunction in women identification of multiple independent susceptibility loci in the hla region in beh et s disease new findings on genetic risks of beh et s disease effect of statin treatment vs usual care on primary cardiovascular prevention among older adults was a statin beneficial for primary cardiovascular prevention in older adults ? rapamycin reverses hypertrophic cardiomyopathy in a mouse model of leopard syndrome associated ptpn mutation study identifies a developmental cause of cardiac hypertrophy lift calculations based on accepted wake models for animal flight are inconsistent and sensitive to vortex dynamics birds flying through laser light reveal faults in flight research study shows social status mediates the fitness costs of infection with canine distemper virus in serengeti spotted hyenas hyena population recovered slowly from a disease epidemic gremlin identifies a skeletal stem cell with bone cartilage and reticular stromal potential bone stem cells shown to regenerate bones cartilage in adult mice antidepressant like effects of bu a novel buprenorphine analogue with mixed receptor antagonist properties in mice new drug shows potential as a different kind of antidepressant in mouse trials easing the pain of an economic downturn macroeconomic conditions and excessive alcohol consumption macroeconomic conditions and alcohol consumption when the economy is down alcohol consumption goes up night time lighting alters the composition of marine epifaunal communities coastal light pollution disturbs marine animals new study shows the cyclin dependent kinase inhibitor palbociclib in combination with letrozole versus letrozole alone as first line treatment of oestrogen receptor positive her negative advanced breast cancer paloma trio a randomised phase study new study finds promising drug doubled positive effect in hormone receptor positive breast cancer to what extent does hydrological connectivity control dynamics of faecal indicator organisms in streams ? initial hypothesis testing using a tracer aided model going with the flow how fecal bacteria spread in streams hydromorphone compared with diacetylmorphine for long term opioid dependence hydromorphone vs. diacetylmorphine for long term opioid addiction a journey around the world parent narratives of the journey to pediatric resective epilepsy surgery and beyond parents describe arduous journey to pediatric epileptic surgery when their child s disease becomes resistant to anti seizure meds the relationship between tobacco smoke exposure and airflow obstruction in us children mothers who smoke while pregnant contribute to the severity of asthma and poor lung function in their children impact of specific medical interventions in early childhood on increasing the prevalence of later intellectual disability relationship of medical interventions in childhood and prevalence of later intellectual disability exposure to a high fat diet during early development programs behavior and impairs the central serotonergic system in juvenile non human primates high fat diet in pregnancy can cause mental health problems in offspring feeding strategy shapes gut metagenomic enrichment and functional specialization in captive lemurs. lemur study highlights role of diet in shaping gut microbiome restricted leucine zipper dimerization and specificity of dna recognition of the melanocyte master regulator mitf x ray analysis deciphers master regulator important for skin cancer machine learning helps identify chrono as a circadian clock component bioinformatics profiling identifies a new mammalian clock gene sensitive electromechanical sensors using viscoelastic graphene polymer nanocomposites graphene with silly putty make state of the art sensors old and unemployable ? how age based stereotypes affect willingness to hire job candidates too old to hire ? research confirms age discrimination in job markets executive function deficits in kindergarten predict repeated academic difficulties across elementary school kindergarten difficulties may predict academic achievement across primary grades darkness alters maturation of visual cortex and promotes fast recovery from monocular deprivation vision restored with total darkness in kittens with amblyopia bone microarchitecture in men and women with diabetes the importance of cortical porosity virtual bone biopsy helps identify why people with diabetes are at risk of bone fractures quality of life of caregivers of older patients with advanced cancer caring for an older adult with cancer comes with emotional challenges for caregivers too guillain barre syndrome and adjuvanted pandemic influenza a h n vaccine multinational case control study in europe no substantial link between swine flu vaccine and guillain barre syndrome experts confirm early life experience affects honey bee aggression and resilience to immune challenge wimps or warriors ? honey bee larvae absorb the social culture of the hive study finds suicide and violent deaths in survivors of cancer in childhood adolescence and young adulthood a national cohort study young cancer survivors have twice the risk of suicide frequent sugar sweetened beverage consumption and the onset of cardiometabolic diseases cause for concern ? sugar sweetened drinks raise risk of diabetes metabolic syndrome non health care facility medication errors resulting in serious medical outcomes rate of medication errors resulting in serious medical outcomes rising study finds inter facility transfer of pediatric burn patients from u.s. emergency departments new study finds low transfer rates of pediatric burn patients in the united states a new genus and species of the frogfish family antennariidae teleostei lophiiformes antennarioidei from new south wales australia with a diagnosis and key to the genera of the histiophryninae new fish genus species named for its red fingerlike fins children s familiarity with snack foods changes expectations about fullness familiarity increases the fullness that children expect from snack foods a disposable power source in resource limited environments a paper based biobattery generating electricity from wastewater origami ninja star inspires new battery that runs on a few drops of dirty water environmental dna from residual saliva for efficient noninvasive genetic monitoring of brown bears ursus arctos the golden drool study finds treasure trove of info in saliva of foraging bears effect of self monitoring and medication self titration on systolic blood pressure in hypertensive patients at high risk of cardiovascular disease hypertension self management program helps reduce blood pressure for high risk patients prevalence of undiagnosed age related macular degeneration in primary eye care underdiagnoses of age related macular degeneration findings suggest association between regulatory advisories and codeine prescribing to postpartum women public health advisories linked with reduction of codeine dispensing to postpartum women endocrine disruptors manmade and natural oestrogens opposite effects on assisted reproduction bpa determined to have adverse effects on couples seeking in vitro fertilization the use of bedaquiline in regimens to treat drug resistant and drug susceptible tuberculosis a perspective from tuberculosis affected communities novel treatment for drug resistant tuberculosis shows promise but concerns for patient safety remain shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap autism schizophrenia bipolar disorder share molecular traits study finds lipid nanoparticle sirna treatment of ebola virus makona infected nonhuman primates new ebola treatment effective three days after infection aero propulsive and propulsor cross coupling effects on a distributed propulsion system opening communication lines between propulsion and airflow poses new questions a genome wide perspective of genetic variation in human metabolism genetic causes identified for disturbances in lipid metabolism implications for diabetes rare copy number variants in nrxn and cntn increase risk for tourette syndrome genetic gains and losses in tourette syndrome uncovered solution structure and membrane interaction of the cytoplasmic tail of hiv gp protein last unknown structure of hiv solved another step in efforts to disarm the aids virus molecular gas in the halo fuels the growth of a massive cluster galaxy at high redshift embryonic cluster galaxy immersed in giant cloud of cold gas surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers surgical adhesions can be treated prevented in mice trastuzumab resistant cells rely on a her pi k foxo survivin axis and are sensitive to pi k inhibitors treatment targeting pi k may delay resistance to anti her therapy in breast cancer patients rose geranium in sesame oil nasal spray a treatment for nasal vestibulitis ? rose geranium oil may ease common painful nasal symptoms linked to cancer treatment prevalence of symptomatic pelvic floor disorders in us women incontinence affects a substantial proportion of women prevalence increases with age emperors on thin ice three years of breeding failure at halley bay catastrophic breeding failure at one of world s largest emperor penguin colonies rapid point of care hiv testing in youth a systematic review youth prefer benefit more from rapid point of care hiv testing metabolic enzyme pfkfb activates transcriptional coactivator src to drive breast cancer answers to year old mystery point to potential breast cancer therapies video gaming among high school students health correlates gender differences and problematic gaming when video games get problematic so do smoking drug use and aggression evolution of a functional head joint in deep sea fishes stomiidae a head joint found in deep sea fishes may enable them to swallow large prey gold nanoparticle enabled blood test for early stage cancer detection and risk assessment one dollar blood test using gold nanoparticles outperforms psa screen for prostate cancer study suggests government inaction on ratings and government subsidies to the us film industry help promote youth smoking government subsidies to the us film industry promote youth smoking argue researchers text mining mental health reports for issues impacting today s college students qualitative study racism sexual assault contribute to college mental health challenges study finds intracranial low grade gliomas in adults year experience with long term follow up at mayo clinic best treatments for long term survival in brain tumor patients identified parent binge eating and restrictive feeding practices indirect effects of parent s responses to child s negative emotion parents binge eating restrictive feeding practices may be reactions to kids emotions a kinase start gene confers temperature dependent resistance to wheat stripe rust wheat gene with resistance to stripe rust discovered beyond the pain scale provider communication and staffing predictive of patients satisfaction with pain control patient satisfaction with pain management linked to nurse staffing metastasis associated prl induces egfr activation and addiction in cancer cells synergy between two cancer linked proteins offers hope for personalized cancer therapy region wide synchrony and traveling waves of dengue across eight countries in southeast asia link between dengue epidemics high temperatures during strong el ni o season use of online social network sites for personal purposes at work does it impair self reported performance ? use of private social media affects work performance hospital case volume is associated with mortality in patients hospitalized with subarachnoid hemorrhage for brain hemorrhage risk of death lower at high volume hospitals a novel automated mammographic density measure and breast cancer risk automated breast density test identifies women at high cancer risk sociodemographic risk factors associated with autism spectrum disorders and intellectual disability autism intellectual disabilities related to parental age education and ethnicity not income utah study finds genome downsizing physiological novelty and the global dominance of flowering plants solving darwin s abominable mystery how flowering plants conquered the world postpartum psychosis madness mania and melancholia in motherhood postpartum psychosis big risk for mothers with bipolar disorder clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium womb natural killer cell discovery could lead to screening for miscarriage risk how much is enough in a perfect world ? cultural variation in ideal levels of happiness pleasure freedom health self esteem longevity and intelligence around the world people have surprisingly modest notions of the ideal life physical activity and other health risk behaviors during the transition into early adulthood young adults drop exercise with move to college or university an integrated perspective on diabetic alcoholic and drug induced neuropathy etiology and treatment in the us integrated perspective on diabetic alcoholic and drug induced modeling the natural history of pelizaeus merzbacher disease rare neurological disease shines light on health of essential nerve cells associations between endocrine disrupting chemicals and equine metabolic syndrome phenotypes endocrine disrupting chemicals linked to equine metabolic syndrome study shows diffusion tensor imaging of dolphin brains reveals direct auditory pathway to temporal lobe first images of dolphin brain circuitry hint at how they sense sound nucleus accumbens functional connectivity at age is associated with trajectory of adolescent cannabis use and predicts psychosocial functioning in young adulthood pattern of marijuana use during adolescence may impact psychosocial outcomes in adulthood keeping cool enhanced optical reflection and heat dissipation in silver ants staying cool saharan silver ants heat deflecting adaptations sers active charged microgels for size and charge selective molecular analysis of complex biological samples a molecular sensor for in situ analysis of complex biological fluids vitamin d deficiency and anthropometric indicators of adiposity in school age children a prospective study low blood levels of vitamin d linked to chubbier kids faster weight gain structural integrity and developmental potential of spermatozoa following microwave assisted drying in the domestic cat model advance achieved in dry preservation of mammalian sperm cells prevalence of adiposity and its association with sleep duration quality and timing among year old children in guangzhou china late bedtime and lack of sleep lead to overweight children in china evolution of the wheat blast fungus through functional losses in a host specificity determinant protecting wheat from wheat blast fungus a potentially devastating disease a spectacular new philippine monitor lizard reveals a hidden biogeographic boundary and a novel flagship species for conservation spectacular new giant fruit eating lizard species discovered in sierra madres of northern philippines when giant stick insects play with colors molecular phylogeny of the achriopterini and description of two new splendid species phasmatodea achrioptera from madagascar love island flamboyant males get the girls on madagascar preoperative patient reported mental health is associated with high grade complications after radical cystectomy mental health status prior to bladder cancer surgery can indicate risk of complications single port donor nephrectomy provides improved patient satisfaction and equivalent outcomes belly button kidney removal boosts living donor satisfaction association between ambient air pollution and cardiac morpho functional phenotypes insights from the uk biobank population imaging study even low levels of air pollution linked with serious changes in the heart according to new uk research it still affects our economic situation long term economic burden of breast cancer and lymphedema the long term financial toll of breast cancer de novo tbr mutations in sporadic autism disrupt protein functions spontaneous mutations in key brain gene are a cause of autism study concludes year efficacy of a bivalent killed whole cell oral cholera vaccine in kolkata india a cluster randomised double blind placebo controlled trial first real life trial finds oral cholera vaccine protects against endemic disease could speed up global control efforts no recovery of replication competent hiv from human liver macrophages hiv in liver cells found to be inactive narrowing potential treatment targets osteogenic embryoid body derived material induces bone formation in vivo scientists regenerate bone tissue using only proteins secreted by stem cells impact of yoga based mind body intervention on systemic inflammatory markers and co morbid depression in active rheumatoid arthritis patients a randomized controlled trial yoga regimen reduces severity of rheumatoid arthritis symptoms increased bioethanol production from commercial tobacco cultivars overexpressing thioredoxin f grown under field conditions genetically modified tobacco plants as an alternative for producing bioethanol controlling asthma by training of capnometry assisted hypoventilation catch vs slow breathing asthma patients reduce symptoms improve lung function with shallow breaths more carbon dioxide gs an oral agonist of toll like receptor induces prolonged suppression of hepatitis b virus in chronically infected chimpanzees new drug stimulates immune system to kill infected cells in animal model of hepatitis b infection description and phylogeny of three new species of synophis colubridae dipsadinae from the tropical andes in ecuador and peru three new fishing snake species fished out of the andean slopes in south america zika virus related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice like zika west nile virus causes fetal brain damage death in mice cross protection of dengue virus infection against congenital zika syndrome northeastern brazil early dengue virus infection could defuse zika virus multifaceted mechanisms of hiv entry inhibition by human defensin under the right conditions peptide blocks hiv infection at multiple points along the way a diffusion tensor imaging study in children with adhd autism spectrum disorder ocd and matched controls distinct and non distinct white matter disruption and dimensional brain behavior relationships common brain changes found in children with autism adhd and ocd fulfilling the taxonomic consequence after dna barcoding carychium panamaense sp. n. eupulmonata ellobioidea carychiidae from panama is described using computed tomographic ct imaging tiny thorn snail discovered in panama s backyard national variability in intracranial pressure monitoring and craniotomy for children with moderate to severe traumatic brain injury hospitals vary in monitoring treatment of children with brain injury treatment factors associated with survival in early stage oral cavity cancer analysis of cases from the national cancer data base study examines treatment factors associated with oral cavity cancer survival tissue adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy bioadhesive wirelessly powered implant emitting light to kill cancer cells tomonaga luttinger liquid in a box electrons confined within mos mirror twin boundaries physics behavior of trapped electrons in a one dimensional world observed in the lab alcohol dependence disrupts amygdalar l type voltage gated calcium channel mechanisms surprising brain change appears to drive alcohol dependence recent mountain pine beetle outbreaks wildfire severity and postfire tree regeneration in the us northern rockies mountain pine beetles get bad rap for wildfires study says exposure to nitrosamines in thirdhand tobacco smoke increases cancer risk in non smokers health risks posed by third hand tobacco smoke lubricant infused surfaces with built in functional biomolecules exhibit simultaneous repellency and tunable cell adhesion researchers design smart surfaces to repel everything but targeted beneficial exceptions saccharomyces boulardii does not prevent relapse of crohn s disease probiotics do not prevent relapse in crohn s disease patients evolutionary history of the asian horned frogs megophryinae integrative approaches to timetree dating in the absence of a fossil record timetree dating in the absence of a fossil record in asian horned frogs freezing tolerance in plants requires lipid remodeling at the outer chloroplast membrane novel mechanism protects plants against freezing insights could add to understanding of drought tolerance also the positive impact of perceived union support on union member work meaningfulness examining mechanisms and boundary conditions perceived union support buoys meaningfulness of work measures methane occurrences in aquifers overlying the barnett shale play with a focus on parker county texas researchers link methane in groundwater in parker and hood counties to natural sources use of primary high risk human papillomavirus testing for cervical cancer screening interim clinical guidance new recommendation for cervical cancer screening using hpv test alone immune modulation enables a specialist insect to benefit from antibacterial withanolides in its host plant moth takes advantage of defensive compounds in physalis fruits identification of coupling mechanisms between ultraintense laser light and dense plasmas a breakthrough in the study of laser plasma interactions metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease gut microbe networks differ from norm in obese people systems biology approach reveals depressive burden is associated with a poorer surgical outcome among lumbar spinal stenosis patients a year follow up study even mild depressive symptoms result in poorer lumbar spinal stenosis surgery outcome plasminogen is a key pro inflammatory regulator that accelerates the healing of acute and diabetic wounds discovery promises unique medicine for treatment of chronic and diabetic wounds indigenous knowledge networks in the face of global change the quiet loss of knowledge threatens indigenous communities should we take patients to hospital in cardiac arrest ? stop taking patients in cardiac arrest to hospital says expert grip strength is associated with longitudinal health maintenance and improvement in adolescents grip strength of children gives clues about their future health cervical cancer screening in average risk women best practice advice from the clinical guidelines committee of the american college of physicians acp releases advice for the proper time test and interval for cervical cancer screening improvement of cognitive function after cochlear implantation in elderly patients cochlear implantation improved speech perception cognitive function in older adults neutrophil derived alpha defensins control inflammation by inhibiting macrophage mrna translation immune study offers treatment hope for arthritis patients generation of cardiomyocytes from vascular adventitia resident stem cells heart attack substitute muscle thanks to stem cells phage therapy is highly effective against chronic lung infections with pseudomonas aeruginosa phage therapy shown to kill drug resistant superbug neurocognitive sequelae in adult childhood leukemia survivors related to levels of phosphorylated tau cancer treatment during childhood linked to cognitive problems later in life global meta analysis of the relationship between soil organic matter and crop yields common policy premise on link between soil and crop yield is valid to a point improved prognosis of young patients with breast cancer undergoing breast conserving surgery young breast cancer patients undergoing breast conserving surgery see improved prognosis brief non symbolic approximate number practice enhances subsequent exact symbolic arithmetic in children intuitive number games boost children s math performance design of peptoid peptide macrocycles to inhibit the catenin tcf interaction in prostate cancer new kind of compound shows early promise against prostate cancer species delimitation in endangered groundwater salamanders implications for aquifer management and biodiversity conservation central texas salamanders including newly identified species at risk of extinction mutations in dmrt affect locomotion in horses and spinal circuit function in mice single gene has major impact on gaits in horses and in mice cryptic royal subfamilies in honey bee apis mellifera colonies worker bees select royal sub family members not their own supersisters to be new queens declining relative risk for myocardial infarction among hiv positive compared with hiv negative individuals with access to care dramatic decline in risk for heart attacks among hiv positive kaiser permanente members in california effect of financial incentives on patient use of mailed colorectal cancer screening tests mailing colorectal cancer screening kit found effective regardless of financial incentive breaking snake camouflage humans detect snakes more accurately than other animals under less discernible visual conditions humans recognize partially obscured snakes more easily than other animals deficiency in lrp mediated wnt signaling contributes to synaptic abnormalities and amyloid pathology in alzheimer s disease pathway that contributes to alzheimer s disease revealed by research increasing rates of melanoma among nonwhites in florida compared with the united states melanoma rates among minorities in florida differ from national trends lipid and metabolite deregulation in the breast tissue of women carrying brca and brca genetic mutations mr spectroscopy shows precancerous breast changes in women with brca gene exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations sporadic mutations identified in children with autism spectrum disorders genetic validation of the protein arginine methyltransferase prmt as a candidate therapeutic target in glioblastoma possible new target for future brain cancer drugs enhancing a wnt telomere feedback loop restores intestinal stem cell function in a human organotypic model of dyskeratosis congenita new strategy to reverse the disease dyskeratosis congenita climate change response in europe what s the reality ? analysis of adaptation and mitigation plans from urban areas in countries the reality behind europe s response to climate change reversible retinal vessel closure from vegf induced leukocyte plugging diabetic blindness caused and reversed trapped immune cells in rodent retinas making new connections insights from primate parasite networks primate parasite network analyses show how germs jump from host to host prediction of late disease recurrence and extended adjuvant letrozole benefit by the hoxb il br biomarker biomarker predicts risk of breast cancer recurrence after tamoxifen treatment insights into egg coat assembly and egg sperm interaction from the x ray structure of full length zp egg meets sperm the female side of the story highly active antiretroviral therapy and survival in hiv infected injection drug users highly active antiretroviral therapy of similar benefit for hiv infected injection drug users molecular phylogenetic analysis of nuclear genes suggests a cenozoic over water dispersal origin for the cuban solenodon endangered cuban solenodon evolved after the extinction of dinosaurs emt cells increase breast cancer metastasis via paracrine gli activation in neighbouring tumour cells metastatic breast cancer cells use hedgehog to evilize docile neighbors flourishing despite a cancer diagnosis factors associated with complete mental health in a nationally representative sample of cancer patients aged years and older majority of current and former cancer patients age plus are happy with their life cardiovascular and cerebrovascular emergency department visits associated with wildfire smoke exposure in california in wildfire smoke associated with more er visits for heart stroke ailments among seniors identification of serum microrna signatures for diagnosis of mild traumatic brain injury in a closed head injury model micrornas can be measured in blood as proxies for mild traumatic brain injury functional lacrimal gland regeneration by transplantation of a bioengineered organ germ researchers regenerate a fully functional bioengineered lacrimal gland advancing conservation planning for western chimpanzees using iucn ssc a.p.e.s. the case of a taxon specific database sweeping census provides new population estimate for western chimpanzees concentrations of perfluoroalkyl substances pfass in human embryonic and fetal organs from first second and third trimester pregnancies industrial chemicals pass from mother to fetus throughout pregnancy contracting for on time delivery in the u.s. influenza vaccine supply chain study offers remedy to flu vaccine delivery problems tumor necrosis factor mediated downregulation of spinal astrocytic connexin leads to increased glutamatergic neurotransmission and neuropathic pain in mice new molecular mechanism of neuropathic pain in mice landscape scale spatial heterogeneity in phytodetrital cover and megafauna biomass in the abyss links to modest topographic variation marine snow fuels life on the sea floor loss of p suppresses replication stress induced dna breakage in g s checkpoint deficient cells loss of protein p helps cancer cells multiply in unfavourable conditions inability to suppress salient distractors predicts low visual working memory capacity inability to avoid visual distractions linked to poor short term memory ocular changes in tgf ad rat model of alzheimer s disease variations in eye structure function may reveal features of early stage alzheimer s disease impact of antiretroviral therapy on incidence of pregnancy among hiv infected women in sub saharan africa a cohort study antiretroviral therapy associated with increase in pregnancy in sub saharan africa exercise induced right ventricular dysfunction is associated with ventricular arrhythmias in endurance athletes endurance athletes should be tested while exercising for potentially fatal heart condition invasion of yellow crazy ant anoplolepis gracilipes in a seychelles unesco palm forest invasion of yellow crazy ant in a seychelles unesco palm forest threats and solutions a change in vaccine efficacy and duration of protection explains recent rises in pertussis incidence in the united states whooping cough a small drop in vaccine protection can lead to a case upsurge association between contemporary trends in inferior vena cava filter placement and the us food and drug administration advisory notable decrease in ivc filter usage after fda advisory prediction of seizure likelihood with a long term implanted seizure advisory system in patients with drug resistant epilepsy a first in man study world first study predicts epilepsy seizures in humans soy isoflavones in the prevention of menopausal bone loss and menopausal symptoms a randomized double blind trial soy tablets not associated with reduction in bone loss or menopausal symptoms in women study finds reduced dna methylation and psychopathology following endogenous hypercortisolism a genome wide study cortisol excess hits natural dna process and mental health hard enhancing inferential abilities in adolescence new hope for students in poverty cognitive training can improve brain performance of students in poverty mid cretaceous high arctic stratigraphy climate and oceanic anoxic events extreme global warming of cretaceous period punctuated with significant global cooling the effects of smoking on the rate of postoperative hemorrhage after tonsillectomy and uvulopalatopharyngoplasty study examines association of smoking with hemorrhage after throat surgery origin functional role and clinical impact of fanconi anemia fanca mutations new advances in genetic studies of fanconi anemia patients passive spatial perception facilitates the expression of persistent hippocampal long term depression two dimensional learning viewing computer images causes long term changes in nerve cell connections cross national patterns of gender differences in mathematics a meta analysis few gender differences in math abilities worldwide study finds sublingual immunotherapy for peanut allergy a randomized double blind placebo controlled multicenter trial sublingual immunotherapy shows promise as treatment for peanut allergy economic activity and the spread of viral diseases evidence from high frequency data business cycle drives the spread of viral diseases initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children cystic fibrosis bacterial burden begins during first years of life alternative solid fuel production from paper sludge employing hydrothermal treatment waste from age old paper industry becomes new source of solid fuel androgen action via testicular peritubular myoid cells is essential for male fertility birth control pill for men ? scientists find a hormonal on and off switch for male fertility prevention of low back pain a systematic review and meta analysis exercise associated with prevention of low back pain pollination on the dark side acoustic monitoring reveals impacts of a total solar eclipse on flight behavior and activity schedule of foraging bees a break from the buzz bees go silent during total solar eclipse chronic graft versus host disease burden and late transplant complications are lower following adult double cord blood versus matched unrelated donor peripheral blood transplantation cord blood outperforms matched unrelated donor in bone marrow transplant pd blockade enhances the vaccination induced immune response in glioma new immunotherapy combo effectively treats advanced brain cancer in pre clinical models evaluation of vaccines for h n influenza virus in ferrets reveals the potential for protective single shot immunization single shot vaccines may protect against h n influenza virus fatty acids contribute to the asthma protective effect of unprocessed cow s milk asthma allergies protective factor found in farm milk brain fogginess gas and bloating a link between sibo probiotics and metabolic acidosis probiotic use is a link between brain fogginess severe bloating plasmonic gold nanoparticles modified titania nanotubes for antibacterial application bringing the bling to antibacterials new way to combat bacterial biofilm formation with titanium encrusted with gold nanoparticles sublingual immunization with m based vaccine induces broad protective immunity against influenza promising results in mice on needle free candidate universal vaccine against various flu viruses measurement matters assessing personal qualities other than cognitive ability for educational purposes measures of students non cognitive skills for teacher evaluation school accountability or student diagnosis neurodevelopmental delay in children exposed in utero to hyperemesis gravidarum in utero exposure to extreme morning sickness may cause developmental deficits in children utility and cost evaluation of multiparametric magnetic resonance imaging for the assessment of non alcoholic fatty liver disease digital liver scanning technology could halve the number of liver biopsies needed in the nhs a prospective cohort study of the prevalence of growth facial and central nervous system abnormalities in children with heavy prenatal alcohol exposure cognitive changes may be only sign of fetal alcohol exposure minicd microbicide prevents hiv infection of human mucosal explants and vaginal transmission of shiv p in cynomolgus macaques vaginal microbicide gel may offer a promising strategy for prevention and protection against hiv transmission the intracellular ca channel mcoln is required for sarcolemma repair to prevent muscular dystrophy muscular dystrophy repair the muscles not the genetic defect a rho scaffold integrates the secretory system with feedback mechanisms in regulation of auxin distribution between shoot and root researcher unlocks new tool for biofuel industry the sensation of groove is affected by the interaction of rhythmic and harmonic complexity a groove is better with rhythm and harmony new research shows a microwave metamaterial with integrated power harvesting functionality wireless device converts lost energy into electric power metamaterial cells provide electric power as efficiently as solar panels variation in wind and piscivorous predator fields affecting the survival of atlantic salmon salmo salar in the gulf of maine environmental conditions and predators affect atlantic salmon survival in the gulf of maine cost implications for subsequent perinatal outcomes after ivf stratified by number of embryos transferred a five year analysis of vermont data price of ivf study examines financial savings vs. medical complication costs familial human prion diseases associated with prion protein mutations y x and g v are transmissible to transgenic mice expressing human prion protein transmission risk of familial human prion diseases to mice maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors a pooled analysis of the escale and estelle studies sfce pesticide use during pregnancy linked to increased risk of childhood brain tumors the genome of the largest bony fish ocean sunfish mola mola provides insights into its fast growth rate genome of the world s largest bony fish may explain fast growth rate and large size postconcussion symptoms are associated with cerebral cortical thickness in healthy collegiate and preparatory school ice hockey players youth hockey brain imaging study suggests early marker for concussion damage re imagining the future for desert australia designing an integrated pathway for enhancing liveability a better life in the outback improving living standards in the australian desert region breakup of new orleans households after hurricane katrina break up of new orleans households after katrina an antisense oligonucleotide against sod delivered intrathecally for patients with sod familial amyotrophic lateral sclerosis a phase randomised first in man study phase als trial is first to test antisense treatment of neurodegenerative disease no serious adverse effects reported on the invalidity ofhalitherium schinziikaup mammalia sirenia with comments on systematic consequences killing a name of an extinct sea cow species long term stochastic editing of regenerative anatomy via targeting endogenous bioelectric gradients two headed worms coded bioelectric code behind worm self healing manipulated discontinuity in the responses of ecosystem processes and multifunctionality to altered soil community composition creepy crawlers play key role in structure of grasslands line transect surveys underdetect terrestrial mammals implications for the sustainability of subsistence hunting animal encounter data under detects hunted species in amazon ecosystems the aryl hydrocarbon receptor and its ligands inhibit myofibroblast formation and activation new findings show promise for treatment of graves disease and other ocular disorders climate and land use change impacts on plant distributions in germany climate change threatens one in five plant species in germany changes in colorectal cancer incidence in seven high income countries a population based study colorectal cancer incidence on the rise among young adults in several high income countries correlation of smoking associated dna methylation changes in buccal cells with dna methylation changes in epithelial cancer smoking induces early signs of cancer in cheek swabs morbidity and mortality associated with nosocomial transmission of oseltamivir resistant influenza a h n virus drug resistant influenza a virus potentially serious to high risk patients removal of perineuronal nets disrupts recall of a remote fear memory neurons sugar coating is essential for long term memories the development and validation of a scale to measure attitudes toward women s genitals orgasms sexual health and attitudes about female genitals effects of sodium thiosulfate versus observation on development of cisplatin induced hearing loss in children with cancer accl a multicentre randomised controlled open label phase trial treatment significantly reduces chemotherapy induced hearing loss in children delivery of an enzyme igfii fusion protein to the mouse brain is therapeutic for mucopolysaccharidosis type iiib study holds hope of treatment for deadly genetic disease mps iiib restriction of advanced glycation end products improves insulin resistance in human type diabetes potential role of ager and sirt baby formula inflammatory food toxins found in high levels in infants orbital angiogenesis and lymphangiogenesis in thyroid eye disease researchers shed light on vascular growth factors in thyroid eye disease imaging the water snow line during a protostellar outburst stellar outburst brings water snowline around a young star into view fgf stimulates periodontal regeneration results of a multi center randomized clinical trial growth factor regenerates tooth supporting structures results of a large randomized clinical trial basal melting of ross ice shelf from solar heat absorption in an ice front polynya rapid melting of the world s largest ice shelf linked to solar heat in the ocean deep skull from niah cave and the pleistocene peopling of southeast asia ancient deep skull from borneo full of surprises the influence of mood versus relevant self perceptions in older adults interest in negative health related information. attitudes about health affect how older adults engage with negative health news a switch in g protein coupling for type corticotropin releasing factor receptors promotes excitability in epileptic brains researchers discover why stress leads to increased seizures in epilepsy patients patient violence towards counselors in substance use disorder treatment programs prevalence predictors and responses patient initiated workplace violence affects counselors treatment and outcomes elementary response triggered by transducin in retinal rods revision to common view on how retinal cells in mammals process light congenital heart disease in the older adult a scientific statement from the american heart association middle aged congenital heart disease survivors may need special care reduced north american terrestrial primary productivity linked to anomalous arctic warming warmer arctic linked to weaker vegetation growth in north america projected response of an endangered marine turtle population to climate change rising heat at the beach threatens largest sea turtles climate change models show cognitive function and brain structure in persons with type diabetes mellitus after intensive lowering of blood pressure and lipid levels effect of lowering blood pressure on risk for cognitive decline in patients with diabetes calcification rates of the massive coral siderastrea siderea and crustose coralline algae along the florida keys usa outer reef tract new approach to measuring coral growth offers valuable tool for reef managers surprising growth patterns in the florida keys dynamics and stabilization of the human gut microbiome during the first year of life the infant gut microbiome new studies on its origins and how it s knocked out of balance understanding the perceptions of and emotional barriers to infertility treatment a survey in four european countries fear of treatment puts stress on women undergoing fertility therapy parental preferences for cdkn a p testing of minors parents favor genetic testing for melanoma in their children extraembryonic signals under the control of mga max and smad are required for dorsoventral patterning function of cancer causing gene explored by researchers sexual behaviors among older adults in spain results from a population based national sexual health survey of men and of women over the age of are sexually active spanish study shows developing global norms for sharing data and results during public health emergencies sharing of research data and findings should be the norm in public health emergencies dipeptidyl peptidase dpp inhibition with linagliptin reduces western diet induced myocardial traf ip expression inflammation and fibrosis in female mice diabetes drug prevents stiffening of heart muscle in obese mouse model the influence of home food environments on eating behaviors of overweight and obese women lots of fruits vegetables but lots of high fat snacks home food environment of overweight women medical certificate education controlled study between lectures and flipped classroom flipped classroom enhances learning outcomes in medical certificate education a novel cortical target to enhance hand motor output in humans with spinal cord injury spinal cord injury using cortical targets to improve motor function illness perceptions in the context of differing work participation outcomes exploring the influence of significant others in persistent back pain influence of the family on back pain sufferers helpers increase food abundance in the territory of a cooperatively breeding fish how a fish species in lake tanganyika works together to secure additional food sources effects of progestin only long acting contraception on metabolic markers in obese women certain hormonal contraceptive may pose risk of type diabetes for obese women meta analysis of randomized controlled trials of red meat consumption in comparison with various comparison diets on cardiovascular risk factors substituting healthy plant proteins for red meat lowers risk for heart disease genetic load and potential mutational meltdown in cancer cell populations why haven t cancer cells undergone genetic meltdowns ? is alzheimer s disease associated with previous opioid use ? long term opioid use does not increase risk of alzheimer s disease preliminary evaluation of an analog procedure to assess acceptability of intimate partner violence against women the partner violence acceptability movie task movies as a tool to assess acceptability of intimate partner violence oral cis retinoid for childhood blindness due to leber congenital amaurosis caused by rpe or lrat mutations an open label phase b trial novel treatment discovered for a form of childhood blindness open ocean dead zones in the tropical north atlantic ocean dead zones found in atlantic open waters moving west could lead to mass fish kills use of the spencer technique on collegiate baseball players effect on physical performance and self report measures keeping pitchers in the game potential in osteopathic medicine to prevent shoulder injury loneliness and social isolation as risk factors for coronary heart disease and stroke systematic review and meta analysis of longitudinal observational studies loneliness isolation linked to heightened risk of heart disease stroke pathological video game use among youths a two year longitudinal study risks consequences of video game addiction identified in new study interpretable classification of alzheimer s disease pathologies with a convolutional neural network pipeline artificial intelligence tool vastly scales up alzheimer s research is violent crime increasing or decreasing ? a new methodology to measure repeat attacks making visible the significance of gender and domestic relations new analyses method makes increasing rate of violent crime visible cutaneous innate immune sensing of toll like receptor ligands suppresses t cell immunity by inducing myeloid derived suppressor cells bacterial infections suppress protective immune response in neurodermatitis mapping the genome ofmiscanthus sinensisfor qtl associated with biomass productivity identifying traits early in development could predict future biomass production in miscanthus the theory of planned behavior and competitive driving in china culture crowding and social influence all tied to aggressive driving behavior rate of cervical cancer severe intraepithelial neoplasia and adenocarcinoma in situ in primary hpv dna screening with cytology triage randomised study within organised screening programme hpv test detects more pre cancerous cells than conventional smear test formation of precessing jets by tilted black hole discs in d general relativistic mhd simulations black hole breakthrough new insight into mysterious jets effect of penetrating keratoplasty and keratoprosthesis implantation on the posterior segment of the eye inflammatory factors cause damage to back of eye following keratoprosthesis implantation applying gold standards to in vitro derived germ cells guidelines needed for creating germ cells in vitro scientists state backbone nmr reveals allosteric signal transduction networks in the adrenergic receptor new insights into the function of the main class of drug targets leaf growth response to mild drought natural variation in arabidopsis sheds light on trait architecture study reveals which genes are critical to a plant s response to drought immunomodulatory nanogels overcome restricted immunity in a murine model of gut microbiome mediated metabolic syndrome nanovaccine boosts immunity in sufferers of metabolic syndrome genetically dictated change in host mucus carbohydrate landscape exerts a diet dependent effect on the gut microbiota genetic makeup and diet interact with the microbiome to impact health the m protein of live attenuated influenza vaccine encodes a mutation that reduces replication in human nasal epithelial cells genetic mutation could if altered boost flumist vaccine effectiveness research suggests deep sea archaea fix and share nitrogen in methane consuming microbial consortia chemical imaging of deep sea microorganisms may help explain lingering nitrogen mystery wolf canis lupus feeding habits during the first eight years of its occurrence in germany no fear of the big bad wolf feeding habits of german wolves investigated effects of smoking and solid fuel use on copd lung cancer and tuberculosis in china a time based multiple risk factor modelling study smoking and solid fuel use in homes in china projected to cause millions of deaths microrna is downregulated in esophageal adenocarcinoma cancer stem like cells and promotes a radioresistant phenotype first of its kind cancer stem cell research unlocks clues to treatment resistance a new approach for monitoring ebolavirus in wild great apes monitoring ebola in wild great apes using feces effects of teriparatide versus alendronate for treating glucocorticoid induced osteoporosis teriparatide outperforms alendronate in treating steroid induced osteoporosis polarimetry of small bodies and satellites of our solar system remote sensing for cosmic dust and other celestial bodies integrated records of environmental change and evolution challenge the cambrian explosion ancient records prompt rethink of animal evolution timeline the water footprint of biofuels a drink or drive issue ? biofuel production and water scarcity a drink or drive issue ? alma reveals an inhomogeneous compact rotating dense molecular torus at the ngc nucleus rotating dusty gaseous donut around an active supermassive black hole requirement for diverse tcr specificities determines regulatory t cell activity in a mouse model of autoimmune arthritis regulatory immune cell diversity tempers autoimmunity in rheumatoid arthritis the photochemical ring opening of cyclohexadiene imaged by ultrafast electron diffraction high speed electron camera films molecular movie in hd three new species and the molecular phylogeny of antipathozoanthus from the indo pacific ocean anthozoa hexacorallia zoantharia three new species of zoantharians described from coral reefs across the indo pacific adult hematopoietic progenitors are multipotent in chimeric mice adult stem cells from bone marrow cell replacement tissue repair potential in adult bone marrow stem cells in animal model longest recorded trans pacific migration of a whale shark rhincodon typus whale shark logs longest recorded trans pacific migration opposing effects of cat and dog ownership and allergic sensitization on eczema in an atopic birth cohort dog ownership is associated with reduced eczema in children with dog allergies evaluation of spent coffee obtained from the most common coffeemakers as a source of hydrophilic bioactive compounds used coffee grounds are a rich source of healthful antioxidants optimal control of natural eye head movements minimizes the impact of noise. clear vision despite a heavy head model explains the choice of simple movements synthetic three component hiv v glycopeptide immunogens induce glycan dependent antibody responses new molecule shows promise in hiv vaccine design structural basis of influenza virus fusion inhibition by the antiviral drug arbidol scientists show how drug binds with hidden pocket on flu virus ancient dna from chalcolithic israel reveals the role of population mixture in cultural transformation dna analysis of year old human remains with blue eye mutation the earliest directly dated rock paintings from southern africa new ams radiocarbon dates new research reveals earliest directly dated rock paintings from southern africa associations of objectively measured physical activity and sedentary time with arterial stiffness in pre pubertal children brisk exercise linked to better arterial health already in childhood femtosecond time resolved two photon photoemission studies of ultrafast carrier relaxation in cu o photoelectrodes copper oxide photocathodes laser experiment reveals location of efficiency loss bright spots among the world s coral reefs bright spots shine light on the future of coral reefs ecological and hydroclimate responses to strengthening of the hadley circulation in south america during the late miocene cooling climate grasses and teeth the evolution of south america mammals associations of sedentary behavior physical activity cardiorespiratory fitness and body fat content with pain conditions in children the physical activity and nutrition in children study lifestyle habits linked to pain conditions already in childhood the power and the peril of large administrative databases implications of flawed prostate specific antigen data in seer s ship promoter expression marks activated stem cells in developing mouse mammary tissue adult mammary stem cells in mice identified and isolated for first time hazardous air pollutants associated with upstream oil and natural gas development a critical synthesis of current peer reviewed literature current methods may inadequately measure health impacts from oil natural gas extraction female human ipscs retain an inactive x chromosome induced pluripotent stem cell retain an inactivated x chromosome study finds the k core as a predictor of structural collapse in mutualistic ecosystems k core is a predictor of structural collapse in mutualistic ecosystems a liquid phase of synapsin and lipid vesicles protein droplets keep neurons at the ready and immune system in balance vectored immunoprophylaxis protects humanized mice from mucosal hiv transmission antibody treatment used by researchers to protect humanized mice from hiv mental physical and behavioral outcomes associated with perceived work stress in police officers work stress associated with adverse mental and physical health outcomes in police officers torso like mediates extracellular accumulation of furin cleaved trunk to pattern the drosophila embryo termini making heads and tails of embryo development lessons from the humble fly self report captures distinct categories of emotion bridged by continuous gradients emoji fans take heart scientists pinpoint states of emotion nanoparticle encapsulated doxorubicin enhances cryoablation of cancer stem like cells cancer stem cells destroyed with cryoablation and nanoparticle encapsulated anticancer drug direct metabolite detection with an n type accumulation mode organic electrochemical transistor low cost plastic sensors could monitor a range of health conditions the r r myb transcription factor duo activates a male germline specific regulon essential for sperm cell differentiation in arabidopsis biologists discover control center for sperm production study uncovers genetic hierarchy in plant sperm formation the value of confirmatory testing in early infant hiv diagnosis programmes in south africa a cost effectiveness analysis second hiv test helps prevent incorrect hiv diagnosis in infants crop domestication facilitated rapid geographical expansion of a specialist pollinator the squash bee peponapis pruinosa how squash agriculture spread bees in pre columbian north america super resolution imaging of the extracellular space in living brain tissue a look at the space between mouse brain cells hypertrophic cardiomyopathy in noonan syndrome treated by mek inhibition a promising new treatment for infants with noonan syndrome tau mediated nmda receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia potential therapy for second most common form of dementia risk factors fortoxoplasma gondiiexposure in semiaquatic mammals in a freshwater ecosystem illinois muskrats minks harbor toxoplasmosis a cat disease effect of host tumor diagnostic and treatment variables on outcomes in a large cohort with merkel cell carcinoma radiation best treatment for rare skin cancer study finds equivalency of fecal immunochemical tests and colonoscopy in familial colorectal cancer screening support for fecal testing in familial colorectal cancer screening population growth and status of california sea lions california sea lion population rebounded to new highs co extinction in a host parasite network identifying key hosts for network stability species extinction can doom parasites important for ecosystem health biospheric feedback effects in a synchronously coupled model of human and earth systems titan simulations show importance of close two way coupling between human and earth systems head impact exposure in youth football high school ages to years and cumulative impact analysis new way to measure cumulative effect of head hits in football blast exposure causes early and persistent aberrant phospho and cleaved tau expression in a murine model of mild blast induced traumatic brain injury single mild blast exposure can cause brain injuries similar to alzheimer s disease mutant glialcam causes megalencephalic leukoencephalopathy with subcortical cysts benign familial macrocephaly and macrocephaly with retardation and autism white matter disease genetic mutation causing mlc identified abrupt global ocean anoxia during the late ordovician early silurian detected using uranium isotopes of marine carbonates widespread ocean anoxia was cause for past mass extinction stressful life memories relate to ruminative thoughts in women with sexual violence history irrespective of ptsd sexual violence haunts women with vivid memories decades later jewelled spider flies of north america a revision and phylogeny of eulonchus gerstaecker diptera acroceridae flying jewels spell death for tarantulas study of a north american spider fly genus antisense oligonucleotides targeting mutant ataxin restore visual function in a mouse model of spinocerebellar ataxia type new study offers hope for patients suffering from a rare form of blindness a new metriorhynchid crocodylomorph from the oxford clay formation middle jurassic of england with implications for the origin and diversification of geosaurini monstrous crocodile fossil points to early rise of ancient reptiles reduced laughter contagion in boys at risk for psychopathy for boys at risk of psychopathy laughter isn t so contagious predicting cetacean distributions in data poor marine ecosystems data on blue whales off california helps protect their distant relatives altered neuronal network and rescue in a human mecp duplication model stem cell derived mini brains reveal potential drug treatment for rare disorder the golden ratio reveals geometric differences in proboscis coiling among butterflies of different feeding habits sap feeding butterflies join ranks of natural phenomenon the golden ratio modeling non syndromic autism and the impact of trpc disruption in human neurons multiple models reveal new genetic links in autism an osteopontin cd axis in rhogdi mediated metastasis suppression double negative leads to big positive against bladder cancer metastasis migration from mexico to the united states and subsequent risk for depressive and anxiety disorders a cross national study mexican migrants to the us risk clinically significant mental health problems study finds impact of the establishment of us offshore wind power on neodymium flows the complicated future of offshore wind power in the us isoform level gene signature improves prognostic stratification and accurately classifies glioblastoma subtypes gene test developed to accurately classify brain tumors distinct cerebrospinal fluid proteomes differentiate post treatment lyme disease from chronic fatigue syndrome spinal fluid proteins distinguish lyme disease from chronic fatigue syndrome sulforaphane preconditioning sensitizes human colon cancer cells towards the bioreductive anticancer prodrug pr a broccoli ingredient has positive influence on drug efficacy high speed polarization resolved coherent raman scattering imaging new imaging technique able to watch molecular dynamics of neurodegenerative diseases epidural steroid injections are associated with less improvement in patients with lumbar spinal stenosis steroid injection may lead to worse outcomes in patients with spinal stenosis a common haplotype lowers pu. expression in myeloid cells and delays onset of alzheimer s disease alzheimer s disease risk linked to a network of genes associated with myeloid cells maternal loss of ube a produces an excitatory inhibitory imbalance through neuron type specific synaptic defects brain cell activity imbalance may account for seizure susceptibility in angelman syndrome association between hospital trauma designation and maternal and neonatal outcomes after injury among pregnant women in washington state trauma experts study treatment of pregnant trauma patients to improve neonatal outcomes metabolic consequences of long term rapamycin exposure on common marmoset monkeys callithrix jacchus study shows promising safety results for anti aging drug a new middle jurassic diplodocoid suggests an earlier dispersal and diversification of sauropod dinosaurs new dinosaur found in the wrong place at the wrong time comparison of the dynamics of japanese encephalitis virus circulation in sentinel pigs between a rural and a peri urban setting in cambodia japanese encephalitis is transmitted to pigs as rapidly in cambodian peri urban areas as rural areas the association between gestational diabetes mellitus and postpartum depressive symptomatology a prospective cohort study gestational diabetes may predispose to postpartum depression symptoms prospective association between microglobulin levels and ischemic stroke risk among women higher levels of biomarker linked to increased stroke risk for women prions in the urine of patients with variant creutzfeldt jakob disease infectious prion protein discovered in urine of patients with variant creutzfeldt jakob disease body mass index and treatment outcomes in metastatic breast cancer patients treated with eribulin eribulin and body mass in metastatic breast cancer news from the hardest front of the battle a comparison of nurse practitioners physician assistants and primary care physicians patterns of practice and quality of care in health centers care by physicians non physician clinicians does not differ in community health centers thallium isotopes reveal protracted anoxia during the toarcian early jurassic associated with volcanism carbon burial and mass extinction volcanic activity declining ocean oxygen triggered mass extinction of ancient organisms ant larvae as players in social conflict relatedness and individual identity mediate cannibalism intensity far from powerless ant larvae cannibalize eggs are influenced by relatedness sex directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and a type lamins when dna gets sent to time out new details revealed in the coordinated regulation of large stretches of dna social environment is associated with gene regulatory variation in the rhesus macaque immune system social stress changes immune system gene expression in primates human recombinant hyaluronidase injections for upper limb muscle stiffness in individuals with cerebral injury a case series enzyme hyaluronidase shows promise as treatment for muscle stiffness caused by brain injury transoral robotic assisted surgery for head and neck squamous cell carcinoma one and year survival analysis robotic surgery for head and neck cancer shows promise childhood maltreatment affects the serotonergic system in male alcohol dependent individuals childhood emotional abuse dramatically strong among male alcohol dependent individuals versatile van der waals epitaxy like growth of crystal films using two dimensional nanosheets as a seed layer orientation tuning of srtio films along three important axes on glass substrates crystal film growth nanosheets extend epitaxial growth applications the arabidopsis gtl transcription factor regulates water use efficiency and drought tolerance by modulating stomatal density via transrepression of sdd gene helps plants use less water without biomass loss anorexia nervosa and obesity are associated with opposite brain reward response brain circuitry is different for women with anorexia and obesity blurred lines multiple freshwater and marine algal toxins at the land sea interface of san francisco bay california four kinds of algal toxins found in san francisco bay shellfish breast cancer in female survivors of wilms tumor a report from the national wilms tumor late effects study chest radiation to treat childhood cancer increases patients risk of breast cancer phylogeny and taxonomy of flatheads scorpionfishes sea robins and stonefishes percomorpha scorpaeniformes and the evolution of the lachrymal saber switchblade like defensive system redraws family tree of stonefishes targeting the histone methyltransferase g a activates imprinted genes and improves survival of a mouse model of prader willi syndrome experimental therapy for prader willi syndrome shows promise in mice robust comparison of climate models with observations using blended land air and ocean sea surface temperatures new study narrows the gap between climate models and reality a specific ifih gain of function mutation causes singleton merten syndrome research probes molecular basis of rare genetic disorder patient specific factors associated with dissatisfaction after elective surgery for degenerative spine diseases patient satisfaction is good indicator of success after spinal surgery auxetic nuclei in embryonic stem cells exiting pluripotency bulletproof nuclei ? stem cells exhibit unusual absorption property noniterative digital aberration correction for cellular resolution retinal optical coherence tomography in vivo new oct technique provides better d imaging of the cellular structure of the eye breast cancer screening using tomosynthesis and digital mammography in dense and nondense breasts breast density outcomes of supplemental breast cancer screening use of f fdg pet to predict response to first line tuberculostatics in hiv associated tuberculosis pet scans predict effectiveness of treatment for multidrug resistant tuberculosis in hiv patients revalorization of coffee by products. prebiotic antimicrobial and antioxidant properties antioxidant effects of coffee by products times greater than vitamin c androgen deprivation therapy for prostate cancer and dementia risk a systematic review and meta analysis link between common prostate cancer treatment dementia detailed in new study atomristor nonvolatile resistance switching in atomic sheets of transition metal dichalcogenides ultra thin memory storage device paves way for more powerful computing a phylogenetic transform enhances analysis of compositional microbiota data microbes evolved to colonize different parts of the human body in vivo interplay between p kip gata atoh and pou f converts non sensory cells to hair cells in adult mice success of sensory cell regeneration raises hope for hearing restoration hydroxycholesterol protects host against zika virus infection and its associated microcephaly in a mouse model immune molecule protects against zika virus infection in animal models a multi stakeholder consensus driven research agenda for better understanding and supporting the emotional impact of harmful events on patients and families healing after harm addressing the emotional toll of harmful medical events structure based discovery of small molecule inhibitors of cariogenic virulence small molecule inhibitor prevents or impedes tooth cavities in a preclinical model detection of evolutionarily distinct avian influenza a viruses in antarctica distinct avian influenza viruses found in antarctic penguins personalized diagnosis and management of congenital cataract by next generation sequencing new dna test for diagnosing diseases linked to childhood blindness the impact of rotating shift work on the prevalence of irritable bowel syndrome in nurses shift workers at more risk for irritable bowel syndrome study finds fishery yields vary with land cover on the amazon river floodplain links between deforestation fisheries yields in the amazon discovered increase in acidifying water in the western arctic ocean acidification of arctic ocean may threaten marine life fishing industry effects of biological monitoring and results outreach on private landowner conservation management personal outreach to landowners is vital to conservation program success reduced cortical thickness in abstinent alcoholics and association with alcoholic behavior chronic drinking leads to reduced cortical thickness in frontal and temporal brain regions aging associated inflammation promotes selection for adaptive oncogenic events in b cell progenitors natural selection inflammation may hold key to age associated cancer risk host insect species of ophiocordyceps sinensis a review chinese researchers identify insect host species of a famous tibetan medicinal fungus risk factors for visual field progression in treated glaucoma research identifies risk factors associated with progression of glaucoma work related traumatic injuries onboard freezer trawlers and freezer longliners operating in alaskan waters during changes in processing handling could reduce commercial fishing injuries serum lipid profile and risk of prostate cancer recurrence results from the search database elevated cholesterol triglycerides may increase risk for prostate cancer recurrence interactive robogami an end to end system for design of robots with ground locomotion designing custom robots in a matter of minutes coffee alcohol and other beverages in relation to cirrhosis mortality the singapore chinese health study coffee consumption reduces mortality risk from liver cirrhosis cancer secreted hsa mir induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting arhgap and fam a metastatic cancer cells modify bone remodeling with small rna secretion in bone metastasis precision medicine genetic repair of retinitis pigmentosa in patient derived stem cells crispr used to repair blindness causing genetic defect in patient derived stem cells invasive lobular carcinoma cell lines are characterized by unique estrogen mediated gene expression patterns and altered tamoxifen response common breast cancer subtype may benefit from personalized treatment approach the enduring effects of mother child interactions on episodic memory in adulthood the enduring effects of mother child interactions as children become adults lmmune response to pandemic influenza a ph n vaccination in pediatric liver transplant recipients single dose h n vaccine not reliable protection for pediatric liver transplant patients myeloid dendritic cells from human cutaneous squamous cell carcinoma are poor stimulators of t cell proliferation to spread skin cancer attacks immune dendritic cells changes in cigarette use and nicotine dependence in the united states evidence from the wave of the national epidemiologic survey of alcoholism and related conditions nicotine dependence remains prevalent despite recent declines in cigarette use smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma researchers kill brain cancer in mice with combination immunotherapies disparities in the food environments of new york city public schools nyc public school students have high levels of access to convenience stores with unhealthy food study finds the global economic and health burden of human hookworm infection human hookworm infection exerts high health and economic burden structural basis of tir domain assembly formation in mal and myd dependent tlr signaling new drug therapy targets in a range of diseases reducing the energy cost of human walking using an unpowered exoskeleton springing ahead of nature device increases walking efficiency plastic surgery improves long term weight control after bariatric surgery body contouring improves long term weight control after gastric bypass improved maize reference genome with single molecule technologies detailed new genome for maize shows the plant has deep resources for continued adaptation peripartum exposure to antibiotics promotes persistent gut dysbiosis immune imbalance and colitis in genetically prone offspring antibiotics taken late in pregnancy can increase risk for inflammatory bowel diseases in offspring mapping thermal expansion coefficients in freestanding d materials at the nanometer scale measuring the temperature of two dimensional materials at the atomic level engineering thrombin for selective specificity toward protein c and par investigators perfect new version of blood regulator thrombin zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune receptor tlr zika virus may cause microcephaly by hijacking human immune molecule local floods induce large scale abrupt failures of road networks as climate changes small increases in rainfall may cause widespread road outages engineering quantitative trait variation for crop improvement by genome editing plant geneticists develop a new application of crispr to break yield barriers in crops automatic emotion and attention analysis of young children at home a researchkit autism feasibility study mobile app for autism screening yields useful data reducing debt improves psychological functioning and changes decision making in the poor debt relief improves psychological and cognitive function enabling better decision making global funding trends for malaria research in sub saharan africa a systematic analysis inequalities in malaria research funding in sub saharan africa patterns of comorbidity among girls with adhd a meta analysis adhd diagnosis puts girls at much higher risk for other mental health problems plasticity of the human visual system after retinal gene therapy in patients with leber s congenital amaurosis vision restoring gene therapy also strengthens visual processing pathways in brain the tbi careqol measurement system development and preliminary validation of health related quality of life measures for caregivers of civilians and service members veterans with traumatic brain injury taking care of people with tbi new tool could speed caregiver research energy alignment and recombination in perovskite solar cells weighted influence on the open circuit voltage performance of perovskite solar cells the interface makes the difference vitamin d receptor polymorphisms and breast cancer risk in a high incidence population a pilot study marin county california s high breast cancer rate may be tied to genetics vinpocetine inhibits streptococcus pneumoniae induced upregulation of mucin muc ac expression via induction of mkp phosphatase in the pathogenesis of otitis media anti stroke drug effective treatment for middle ear infections researchers say neural network based geomagnetic estimation for multi site observation system fast accurate estimation of the earth s magnetic field for natural disaster detection association of fish oil supplement use with preservation of brain volume and cognitive function fish oil supplements reduce incidence of cognitive decline may improve memory function a beak size locus in darwin s finches facilitated character displacement during a drought evolution in action detected in darwin s finches nitric oxide releasing nanoparticles prevent propionibacterium acnes induced inflammation by both clearing the organism and inhibiting microbial stimulation of the innate immune response nanoparticles used to prevent inflammatory acne through slow released nitric oxide a behavioral economics intervention to increase pertussis vaccination among infant caregivers a randomized feasibility trial whooping cough booster vouchers don t boost immunization rates of caregivers somatic cell encystment promotes abscission in germline stem cells following a regulated block in cytokinesis fruitfly sperm cells reveal intricate coordination in stem cell replication inhibition of helicoverpa zea growth by transgenic corn expressing bt toxins and development of resistance to cry ab field study shows how a gm crop can have diminishing success at fighting off insect pest maternal perinatal and concurrent depressive symptoms and child behavior problems a sibling comparison study what effect does prenatal and postpartum maternal depression have on children ? time to consider the risks of caesarean delivery for long term child health do newborns delivered by c section face higher risk of chronic health problems later in life ? safety of osseointegrated implants for transfemoral amputees a two center prospective cohort study study finds minimal risk for serious infection with in bone prosthesis historical control monotherapy design in the treatment of epilepsy fda accepts historical controls for epilepsy monotherapy studies tiger re establishment potential to former caspian tiger panthera tigris virgata range in central asia tigers could roam again in central asia scientists say whole brain activity maps reveal stereotyped distributed networks for visuomotor behavior study describes first maps of neural activity in behaving zebrafish the impact of classroom design on pupils learning final results of a holistic multi level analysis well designed classrooms can boost learning progress in primary school pupils by up to in a single year research reveals deletion of glut and glut reveals multiple roles for glucose metabolism in platelet and megakaryocyte function multiple roles of glucose metabolism identified in platelet activation and survival the dendritic cell receptor clec a binds damaged cells via exposed actin filaments manipulating the immune system to develop next gen vaccines a post transcriptional program coordinated by csde prevents intrinsic neural differentiation of human embryonic stem cells improving the neuron factory new modulator of stem cell identity found the hall technique a randomized controlled clinical trial of a novel method of managing carious primary molars in general dental practice acceptability of the technique and outcomes at months simple push filling wins crown in battle against tooth decay the prevalence of mental disorders among the homeless in western countries systematic review and meta regression analysis higher rates of mental illness among the homeless in western countries rationally designed d hydrogels model invasive lung diseases enabling high content drug screening artificial lung cancer tissue could help find new drug treatments maternal cd t cells protect against severe congenital cytomegalovirus disease in a novel nonhuman primate model of placental cytomegalovirus transmission monkey model discovery could spur cmv vaccine development additions to the knowledge of the land snails of sabah malaysia borneo including new species world s tiniest snail record broken with a myriad of new species from borneo hybrid biomembrane functionalized nanorobots for concurrent removal of pathogenic bacteria and toxins cell like nanorobots clear bacteria and toxins from blood acute hepatitis c virus in an hiv clinic a screening strategy risk factors and perception of risk new acute hepatitis c screening strategy for hiv infected patients targeting myc in kshv associated primary effusion lymphoma with bet bromodomain inhibitors research ids potential treatment for deadly hiv related blood cancer proteorhodopsin phototrophy promotes survival of marine bacteria during starvation ocean bacteria can harvest energy from sunlight for survival extreme hydrothermal conditions at an active plate bounding fault extreme geothermal activity discovered beneath new zealand s southern alps a web based sexual violence bystander intervention for male college students randomized controlled trial web based training can reduce campus rape study concludes recurrent domestication by lepidoptera of genes from their parasites mediated by bracoviruses naturally occurring gm butterflies produced by gene transfer of wasp associated viruses molecular signatures of nicotinoid pathogen synergy in the termite gut nicotinoid fungal disease team up to break down termites tough defenses isotopes from fossil coronulid barnacle shells record evidence of migration in multiple pleistocene whale populations deep time tracking devices fossil barnacles reveal prehistoric whale migrations moonlight drives ocean scale mass vertical migration of zooplankton during the arctic winter in arctic winter marine creatures migrate by the light of the moon dogs in funerary contexts during the middle neolithic in the northeastern iberian peninsula th early th millennium bce dog burial as common ritual in neolithic populations of north eastern iberian peninsula object detection in the ring scotoma of a monocular bioptic telescope single bioptic telescope for low vision driving may not obscure road view of second eye site specific bone mineral density is unaltered despite differences in fat free soft tissue mass between affected and nonaffected sides in hemiplegic paralympic athletes with cerebral palsy study of elite paralympic athletes supports benefits of exercise for children with cerebral palsy agricultural and forestry trade drives large share of tropical deforestation emissions eu consumption results in high carbon emissions from tropical deforestation studies show transplantation of wild type mouse hematopoietic stem and progenitor cells ameliorates deficits in a mouse model of friedreich s ataxia transplanted hematopoietic stem cells reverse damage caused by neuro muscular disorder body size changes among national collegiate athletic association new england division iii football players comparison with age matched population controls weights of division iii football linemen up percent since researchers report promoting hpv vaccination in safety net clinics a randomized trial outreach increases completion of hpv vaccination series by adolescent girls context specific reweighting of auditory spatial cues following altered experience during development insights into how brain compensates for recurring hearing loss point to new glue ear therapies excessive social media users demonstrate impaired decision making in the iowa gambling task risky decisions excessive social media use is comparable to drug addiction the unfolded protein response regulator atf promotes mesodermal differentiation in effort to treat rare blinding disease researchers turn stem cells into blood vessels arsenic transformed malignant prostate epithelia can convert noncontiguous normal stem cells into an oncogenic phenotype arsenic turns stem cells cancerous spurring tumor growth stream nitrogen phosphorus and sediment concentrations show contrasting long term trends associated with agricultural change long term agriculture change impacts stream water quality binge eating disorder in the swedish national registers somatic comorbidity binge eating disorder linked to other health conditions an enu induced mutation of mir associated with progressive hearing loss in mice new mouse model for understanding cause of progressive hearing loss arterial co as a potent coronary vasodilator a preclinical pet mr validation study with implications for cardiac stress testing pet mr shows arterial co as potent vasodilator for cardiac stress testing shortening rate and holocene surface rupture on the riasi fault system in the kashmir himalaya active thrusting within the northwest himalayan orogenic wedge new study finds major earthquake threat from the riasi fault in the himalayas from battery enabled to natural harvesting enzymatic biofuel cell assisted integrated analog front end in nm cmos for long term monitoring sugar powered sensor developed to detect prevent disease epigenetics intrauterine growth retardation iugr modifies the histone code along the rat hepatic igf gene the new epigenetics poor nutrition in the womb causes permanent genetic changes in offspring downstream consequences of melanoma screening in a community practice setting first results study finds no substantial harm from primary care melanoma screening body weight affects polyunsaturated fatty acid pufa accumulation in youth following supplementation in post hoc analyses of a randomized controlled trial as kids weight climbs power of healthy fat supplements drops hiv antiretroviral treatment hypertension and stroke in malawian adults a case control study hiv identified as leading risk factor for stroke in young african adults suburbanization estrogen contamination and sex ratio in wild amphibian populations estrogen shrubbery and the sex ratio of suburban frogs characterization of optical properties of zno nanoparticles for quantitative imaging of transdermal transport scientists use laser imaging to assess safety of zinc oxide nanoparticles in sunscreen non specific activities of the major herbicide resistance gene bar large scale approach reveals imperfect actor in plant biotechnology urinary lrrk phosphorylation predicts parkinsonian phenotypes in g slrrk carriers parkinson s disease biomarker found in patient urine samples exercise and vitamin d in fall prevention among older women neither vitamin d nor exercise affected fall rates among older women in finland efficient talen mediated gene targeting of chicken primordial germ cells egg free surrogate chickens produced in bid to save rare breeds animal assisted interventions a national survey of health and safety policies in hospitals eldercare facilities and therapy animal organizations could therapy animal visitation pose health risks at patient facilities ? using the magnetoencephalogram to noninvasively measure magnetite in the living human brain advanced imaging technology measures magnetite levels in the living brain alcohol coffee fish smoking and disease progression in multiple sclerosis lifestyle study highlights key differences in relapsing and progressive onset multiple sclerosis hud housing assistance associated with lower uninsurance rates and unmet medical need hud housing assistance linked to improved health care access auscultation while standing a basic and reliable method to rule out a pathologic heart murmur in children diagnostic test helps primary care docs rule out pathologic heart murmur in kids generation of inner ear sensory epithelia from pluripotent stem cells in d culture researchers create inner ear from stem cells opening potential for new treatments immune mediated hookworm clearance and survival of a marine mammal decreases with warmer ocean temperatures warming oceans lead to more fur seal deaths from hookworm infection genome wide analysis of evolutionary markers of human influenza a h n pdm and a h n viruses may guide selection of vaccine strain candidates a new approach to predict evolution of influenza viruses can enhance vaccine efficacy histone demethylases kdm b and kdm b promotes osteogenic differentiation of human mscs discovery of epigenetic links in cell fate decisions of adult stem cells paves way for new osteoporosis treatments editing activity for eliminating mischarged trnas is essential in mammalian mitochondria quality control is vital for the energy production of cells a single dose of peripherally infused egfrviii directed car t cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma combining car t cells with existing immunotherapies may overcome resistance in glioblastomas savanna in equatorial borneo during the late pleistocene holy pleistocene batman the answer s in the cave inherited mutations in breast cancer susceptibility genes among a large triple negative breast cancer cohort unselected for family history of breast cancer triple negative breast cancer patients should undergo genetic screening thermal hypersensitivity in a subset of irritable bowel syndrome patients is somatic hypersensitivity a predictor of irritable bowel syndrome ? predictors of treatment outcome in contextual cognitive and behavioral therapies for chronic pain a systematic review cognitive behavioral therapy improves functioning for people with chronic pain study shows development of a human antibody cocktail that deploys multiple functions to confer pan ebolavirus protection experimental antibody cocktail protects animals from three deadly ebola viruses the structure of the cysteine protease and lectin like domains of cwp a surface layer associated protein fromclostridium difficile first crystal structure of the c. difficile surface protein cwp spawning aggregations act as a bottleneck influencing climate change impacts on a critically endangered reef fish success of conservation efforts for important caribbean reef fish hinges on climate change a global analysis of multitrial data investigating quality of life and symptoms as prognostic factors for survival in different tumor sites prognostic value of baseline survival determined for types of cancer wise reasoning benefits from emodiversity irrespective of emotional intensity in test of wisdom new research favors yoda over spock intestinal barrier dysfunction orchestrates the onset of inflammatory host microbiome cross talk in a human gut inflammation on a chip gut on a chip system shows intestinal barrier disruption is the onset initiator of gut inflammation the relationship between childhood rules about technology use and later life academic achievement among young adults rules about technology use can undermine academic achievement aurora a kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation two investigational antitumor agents work better together against mpnst and neuroblastoma body size shifts and early warning signals precede the historic collapse of whale stocks lessons from whale population collapse could help future species at risk water wave transmission by an array of floating disks better forecasts for sea ice under climate change effect of waves histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells histones may hold the key to the generation of totipotent stem cells health of medicare advantage plan enrollees at year after hurricane katrina decline in health among older adults affected by hurricane katrina distribution shifts of marine taxa in the pacific arctic under contemporary climate changes mapping species range shifts under recent climatic changes the first woman to give birth to two children following transplantation of frozen thawed ovarian tissue woman gives birth to two healthy babies in separate pregnancies after ovarian transplant competition between apex predators ? brown bears decrease wolf kill rate on two continents wolfing it down brown bears reduce wolf kill rates says usu ecologist real time capable modeling of neutral beam injection on nstx u using neural networks machine learning speeds modeling of experiments aimed at capturing fusion energy on earth morphological and physiological responses of nine ornamental species to saline irrigation water nine ornamental landscape plants tested for salt tolerance barriers and facilitators of access to first trimester abortion services for women in the developed world a systematic review women in developed world still face many barriers to early abortion a new species of peritresius leidy testudines pan cheloniidae from the late cretaceous campanian of alabama usa and the occurrence of the genus within the mississippi embayment of north america new ancestor of modern sea turtles found in alabama at home oral care for adults with developmental disabilities a survey of caregivers to improve oral health of adults with developmental disabilities improve support for caregivers temporal variability largely explains top down bottom up difference in methane emission estimates from a natural gas production region persistent gap in natural gas methane emissions measurements explained favorable cardiovascular health compression of morbidity and healthcare costsclinical perspective golden years are longer and healthier for those with good heart health in middle age fifty year trends in global ocean salinities and their relationship to broad scale warming dry regions becoming drier ocean salinities show an intensified water cycle g protein estrogen receptor as a regulator of low density lipoprotein cholesterol metabolism cellular and population genetic studies estrogen s role in regulating common health disease risks identified mapping the structural organization of the brain in conduct disorder replication of findings in two independent samples map of teenage brain provides strong evidence of link between serious antisocial behavior and brain development a bacteriophage cocktail targeting escherichia coli reduces e. coli in simulated gut conditions while preserving a non targeted representative commensal normal microbiota researchers assassinate disease causing bacteria with virus cocktail hiv infection status immunodeficiency and the incidence of non melanoma skin cancer two fold higher incidence of non melanoma skin cancers for hiv patients association between testosterone levels and risk of future rheumatoid arthritis in men a population based case control study low testosterone levels may herald rheumatoid arthritis in men pnas plus production of unique immunotoxin cancer therapeutics in algal chloroplasts biologists engineer algae to make complex anti cancer designer drug disrupted neuronal maturation in angelman syndrome derived induced pluripotent stem cells stem cells help researchers identify neuronal defects causing angelman syndrome lifetime prevalence of gender based violence in women and the relationship with mental disorders and psychosocial function gender based violence associated with lifetime risk of mental illness and disability research shows how does social media impact bitcoin value ? a test of the silent majority hypothesis how social media s powerful silent majority moves bitcoin prices effects of homocysteine lowering with folic acid plus vitamin b vs placebo on mortality and major morbidity in myocardial infarction survivors a randomized trial lowering homocysteine levels with folic acid and vitamin b does not appear to reduce risk of heart attack stroke study finds documenting female spine motion during coitus with a commentary on the implications for the low back pain patient new findings will improve the sex lives of women with back problems associations of television viewing with eating behaviors in the health behaviour in school aged children study tv viewing linked to unhealthy eating habits in school children combination anti a treatment maximizes cognitive recovery and rebalances mtor signaling in app mice two is better than one to improve brain function in alzheimer s disease mouse model a tiny new marsupial lion marsupialia thylacoleonidae from the early miocene of australia new tiny species of extinct australian marsupial lion named after sir david attenborough a mitochondrial dna hypomorph of cytochrome oxidase specifically impairs male fertility indrosophila melanogaster discovery of male harming dna mutation reinforces mother s curse hypothesis geographic patterns of genetic differentiation among killer whales in the northern north pacific killer whale genetics redefining stock structure in a marine top predator sibling experiences in middle childhood predict sibling differences in college graduation childhood sibling dynamics may predict differences in college education geographic distribution of angiostrongylus cantonensis in wild rats rattus rattus and terrestrial snails in florida usa potentially lethal parasite rat lungworm found throughout florida normalization of hyperhomocysteinemia improves cognitive deficits and ameliorates brain amyloidosis of a transgenic mouse model of alzheimer s disease healthy diet could slow or reverse early effects of alzheimer s disease reducing the contact time of a bouncing drop scientists break a theoretical time barrier on bouncing droplets initial trends in the use of the gene recurrence score assay for patients with breast cancer in the medicare population trends of gene recurrence score assay use in older patients with breast cancer infectivity transmission and pathogenesis of human isolated h n influenza virus in ferrets and pigs ferrets pigs susceptible to h n avian influenza virus increased incidence and mortality associated with skin cancers after cardiac transplant heart transplant patients at risk for serious skin cancers study finds when truth is personally inconvenient attitudes change the impact of extreme weather on implicit support for green politicians and explicit climate change beliefs after the storms a different opinion on climate change overuse of papanicolaou testing among older women and among women without a cervix cervical cancer screenings overused in some groups of women suppression of substance abuse claims in medicaid data and rates of diagnoses for non substance abuse conditions examination of effect of cms policy to suppress substance abuse claims data inhaled hypertonic saline in infants and children younger than years with cystic fibrosisthe isis randomized controlled trialinhaled hypertonic saline in children with cf concentrated saline therapy not effective in young children with cystic fibrosis chlamydia trachomatis inclusion membrane protein mrca interacts with the inositol trisphosphate receptor type itpr to regulate extrusion formation bacterial and host cell proteins interact to regulate chlamydia s exit strategy oceanographic conditions in wintering grounds affect arrival date and body condition in breeding female magellanic penguins after a bad winter in the ocean female magellanic penguins suffer most study shows gfra identifies cardiac progenitors and mediates cardiomyocyte differentiation in a ret independent signaling pathway discovery of molecular marker specific to early embryonic heart development insulin and insulin like growth factor resistance in alcoholic neurodegeneration alcohol abuse can damage the brain by decreasing insulin and insulin like growth factor receptors genetic variation associated with euphorigenic effects of d amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder genetic predisposition to liking amphetamine reduces risk of schizophrenia adhd evaluation of pediatric sensorineural hearing loss with magnetic resonance imaging mri reveals inner ear anomalies in children with hearing loss framing pictorial cigarette warning labels to motivate young smokers to quit identifying a better message strategy for dissuading smokers add the positive transitory microbial habitat in the hyperarid atacama desert life in world s driest desert seen as sign of potential life on mars icebergs not the trigger for north atlantic cold events iceberg armadas not the cause of north atlantic cooling innovative diagnostic tools for early detection of alzheimer s disease speech based system for early detection of alzheimer s disease patterns and determinants of breast and cervical cancer non screening among appalachian women new study examines patterns of cancer screening in appalachian women humpback whale abundance in the north pacific estimated by photographic capture recapture with bias correction from simulation studies new higher estimates of endangered humpback whales in the north pacific targeting nrf with the triterpenoid cddo imidazolide attenuates cigarette smoke induced emphysema and cardiac dysfunction in mice activating the lung s antioxidant defense by targeting nrf inhibits the development of emphysema norrin frizzled signalling in the preneoplastic niche blocks medulloblastoma initiation genetic signaling pathway blocks formation of a cancer in the cerebellum biology ecology and management of masked chafer coleoptera scarabaeidae grubs in turfgrass management techniques for masked chafer grubs in turfgrass increased burden of deleterious variants in essential genes in autism spectrum disorder mutations in life s essential genes tied to autism an unusual association of hadrosaur and therizinosaur tracks within late cretaceous rocks of denali national park alaska first north american co occurrence of hadrosaur and therizinosaur tracks found in alaska an easy and effective method to modulate molecular energy level of the polymer based on benzodithiophene for the application in polymer solar cells simple cheap way to increase solar cell efficiency molecular insights into genome wide association studies of chronic kidney disease defining traits kidney genes linked to chronic kidney disease risk rub tree selection by andean bears in the peruvian dry forest bear necessities new study highlights importance of water resources for andean bears probing lithiation and delithiation of thick sintered lithium ion battery electrodes with neutron imaging through thick and thin neutrons track lithium ions in battery electrodes structural brain alterations in schizophrenia following fetal exposure to the inflammatory cytokine interleukin immune responses during pregnancy linked to schizophrenia among offspring alterations in cholesterol metabolism restrict hiv trans infection in nonprogressors low cholesterol in immune cells tied to slow progression of hiv incidence and outcomes of infections caused by multidrug resistant enterobacteriaceae in children study finds resistant infections rising with longer hospital stays for us children zika prvabc infection is associated with t cell infiltration and neurodegeneration in cns of immunocompetent neonatal c bl mice scientists develop new mouse model to aid zika virus research siv replication in the infected rhesus macaque is limited by the size of the preexisting th cell compartment immune cells in the gut may improve control of hiv growth northern gal pagos corals reveal twentieth century warming in the eastern tropical pacific first evidence of surprising ocean warming around gal pagos corals analysis of the cancer genome atlas sequencing data reveals novel properties of the human papillomavirus genome in head and neck squamous cell carcinoma study redefines hpv related head and neck cancers winter color polymorphisms identify global hot spots for evolutionary rescue from climate change evolutionary rescue areas for animals threatened by climate change allosteric activation of membrane bound glutamate receptors using coordination chemistry within living cells flipping a protein switch to illuminate brain functions a new exceptionally preserved juvenile specimen of eusaurosphargis dalsassoi diapsida and implications for mesozoic marine diapsid phylogeny ancient swiss reptile shows its bizarre scale armor for the first time genetic inhibition of crmp phosphorylation at serine promotes axonal regeneration after optic nerve injury inhibition of protein phosphorylation promotes optic nerve regeneration after injury serum alpha carotene concentrations and risk of death among us adults the third national health and nutrition examination survey follow up study high alpha carotene levels associated with longer life correlates of satisfaction with pain treatment in the acute postoperative period results from the international pain out registry patients report high satisfaction with pain treatment when involved relationship between radiation exposure and risk of second primary cancers among atomic bomb survivors radiation exposure poses similar risk of first and second cancers in atomic bomb survivors new york citywide colon cancer control coalition a public health effort to increase colon cancer screening and address health disparities city wide effort boosts nyc s colorectal cancer screening rates mri defined white matter microstructural alteration associated with soccer heading is more extensive in women than men soccer heading may be riskier for female players short course high dose rifampicin achieves wolbachia depletion predictive of curative outcomes in preclinical models of lymphatic filariasis and onchocerciasis new anti wolbachia drug regimen could reduce treatment times of lf and oncho to weeks l q mutant egfr escapes covalent inhibition by stabilizing a non reactive conformation of the lung cancer drug osimertinib lung cancer drug resistance explained by computer simulations night shift work genetic risk and type diabetes in the uk biobank study examines shift work and genetic risk factors for type diabetes a phase iii equivalence trial of azithromycin versus benzathine penicillin for treatment of early syphilis azithromycin pills equal to penicillin shots for treating early syphilis clinical trial finds curcumin delays development of mpa accelerated dmba induced mammary tumors asian spice could reduce breast cancer risk in women exposed to hormone replacement therapy a phase i clinical study of a live attenuated bordetella pertussis vaccine bpze a single centre double blind placebo controlled dose escalating study of bpze given intranasally to healthy adult male volunteers successful test in humans of nasal vaccine against pertussis low parasite load estimated by qpcr in a cohort of children living in urban area endemic for visceral leishmaniasis in brazil study tracks risk of visceral leishmaniasis vl exposure in brazil s urban areas improving adherence in adolescent chronic kidney disease a dialectical behavior therapy dbt feasibility trial dialectical behavioral therapy improves adherence in teens with chronic illness a view from the front line physicians perspectives on aca repeal repeal all of obamacare ? primary care physicians not in favor survey suggests three cases of imported eyeworm infection in dogs a new threat for the united kingdom parasitic eye infection poses significant threat to uk dogs warn experts pharmacotherapy for adults with alcohol use disorders in outpatient settings effectiveness of medications to treat alcohol use disorders examined coherent x ray spectroscopy reveals the persistence of island arrangements during layer by layer growth scientists track patterns of island growth in crystals memory t cells established by seasonal human influenza a infection cross react with avian influenza a h n in healthy individuals new vaccine element could generate better protection from avian influenza an in vitro model of lissencephaly expanding the role of dcx during neurogenesis cell model of the brain provides new knowledge on developmental disease declines in northern forest tree growth following snowpack decline and soil freezing snowpack declines may stunt tree growth and forests ability to store carbon emissions relationship between antihypertensive medications and cognitive impairment part ii. review of physiology and animal studies from pollution to caffeine intake researcher reveals dementia risks effects of health and social care spending constraints on mortality in england a time trend analysis health social care spending cuts linked to excess deaths in england a drug screen using human ipsc derived hepatocyte like cells reveals cardiac glycosides as a potential treatment for hypercholesterolemia stem cell drug screen yields potential alternative to statins emerging viral disease risk to pollinating insects ecological evolutionary and anthropogenic factors wild pollinators at risk from diseased commercial species of bee use of a virtual world computer environment for international distance education lessons from a pilot project using second life virtual computer based world an effective learning environment for healthcare education study shows prognostic significance of p codon polymorphism differs with race in colorectal adenocarcinoma increase in p mutation linked to advanced colorectal cancer in african americans effect of folic acid food fortification in canada on congenital heart disease subtypesclinical perspective folic acid fortified food linked to decline in congenital heart defects oxidative stress dna damage and inflammation induced by ambient air and wood smoke particulate matter in human a and thp cell lines air pollutants from fireplaces and wood burning stoves raise health concerns khs disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice scientists discover chemical which can kill glioblastoma cells microbial respiration and formate oxidation as metabolic signatures of inflammation associated dysbiosis scientists identify mechanisms driving gut bacterial imbalance and inflammation subsequent primary malignancies in patients with nonmelanoma skin cancer in england a national record linkage study young skin cancer survivors at risk of other cancers later genome sequence of a year old maize cob provides insights into the early stages of maize domestication dna evidence from year old corn cob fills gaps in history inflammatory cytokines and mortality in a cohort of hiv infected adults with alcohol problems study associates pro inflammatory molecules with early death in hiv patients the sami galaxy survey mass as the driver of the kinematic morphology density relation in clusters why massive galaxies don t dance in crowds post fire management affects species composition but not douglas fir regeneration in the klamath mountains salvage logging planting not necessary to regenerate douglas firs after klamath fires livestock animal assets buffer the impact of conflict related traumatic events on mental health symptoms for rural women microfinance program pigs for peace also improves mental health symptoms for women in the democratic republic of congo deletion of densin results in abnormal behaviors associated with mental illness and reduces mglur and disc in the postsynaptic density fraction scientists point to link between missing synapse protein and abnormal behaviors design of a mediterranean exchange list diet implemented by telephone counseling women double fruit veggie intake with switch to mediterranean diet plan the pathogen batrachochytrium dendrobatidis disturbs the frog skin microbiome during a natural epidemic and experimental infection role of microbes effect on infectious disease dynamics content volatility of scientific topics in wikipedia a cautionary tale on wikipedia politically controversial science topics vulnerable to information sabotage association of the anrs male circumcision project with hiv levels among men in a south african township evaluation of effectiveness using cross sectional surveys roll out of community voluntary male circumcision is linked to reduced hiv infection levels improvement of aortic valve stenosis by apoa i mimetic therapy is associated with decreased aortic root and valve remodeling in mice new approach to treat the most common heart valve disease in western countries over the counter access to oral contraceptives for adolescents experts find strong case for over the counter oral contraceptives for adults and teens owning ethical innovation claims about commercial wearable brain technologies examining ethical issues surrounding wearable brain devices marketed to consumers retrospective analysis of f fdg pet ct for staging asymptomatic breast cancer patients younger than years fdg pet ct shows promise for breast cancer patients younger than risk of bias in systematic reviews of non randomized studies of adverse cardiovascular effects of thiazolidinediones and cyclooxygenase inhibitors application of a new cochrane risk of bias tool researchers test new risk of bias assessment tool for non randomized intervention studies negative relationship behavior is more important than positive correlates of outcomes during stressful life events. bad behavior to significant other in tough times has more impact than positive gestures rapid global ocean atmosphere response to southern ocean freshening during the last glacial ancient tree reveals cause of spike in arctic temperature childhood obesity prevention in the women infants and children program outcomes of the ma cord study obesity risk factors dropped in preschoolers in prevention program blue whales respond to simulated mid frequency military sonar military sonar can alter blue whale behavior human made noises cause ocean giants to move away from feeding spots tobacco product waste an environmental approach to reduce tobacco consumption ban cigarette filters to save environment suggest researchers lamin b depletion in senescent cells triggers large scale changes in gene expression and the chromatin landscape balancing act cell senescence aging related to epigenetic changes artificial two dimensional polar metal at room temperature physicists create new class of d artificial materials scheduled intermittent screening with rapid diagnostic tests and treatment with dihydroartemisinin piperaquine versus intermittent preventive therapy with sulfadoxine pyrimethamine for malaria in pregnancy in malawi an open label randomized controlled tr adverse outcomes not improved in novel screen and treat program for malaria in pregnancy a pilot study examining the effects of consuming a high protein vs normal protein breakfast on free living glycemic control in overweight obese breakfast skipping adolescents protein packed breakfast prevents body fat gain in overweight teens rates of adverse events associated with male circumcision in us medical settings to low rate of adverse events associated with male circumcision during first year of life study finds thorium isotopes tracing the iron cycle at the hawaii ocean time series station aloha intensity of desert storms may affect ocean phytoplankton a global biomedical r d fund and mechanism for innovations of public health importance global health leaders call for global biomedical research and development fund mechanism regional localization within the bone marrow influences the functional capacity of human hscs researchers find home of best stem cells for bone marrow transplants decline of coastal apex shark populations over the past half century fifty years of decline in queensland s coastal sharks comparison of asthma prevalence among african american teenage youth attending public high schools in rural georgia and urban detroit asthma rates among black youth are similarly high in urban rural communities genetic susceptibility for childhood bmi has no impact on weight loss following lifestyle intervention in danish children despite common obesity gene variants obese children lose weight after lifestyle changes computational evaluation of cellular metabolic costs successfully predicts genes whose expression is deleterious digital test for toxic genes computer algorithm identifies genes whose activation is lethal to bacteria seamless gene correction of thalassemia mutations in patient specific ipscs using crispr cas and piggybac seamless gene correction of beta thalassemia mutations in patient specific cells heterocyclic amine content in commercial ready to eat meat products good news for meat lovers most ready to eat meat products contain very few cancerous compounds study finds enacyloxins are products of an unusual hybrid modular polyketide synthase encoded by a cryptic burkholderia ambifaria genomic island cystic fibrosis associated bacteria could help fight back against antibiotic resistance preventing zika virus infection during pregnancy using a seasonal window of opportunity for conception conception timed with periods of low mosquito activity could reduce zika virus infection thrombin promotes diet induced obesity through fibrin driven inflammation scientists propose novel therapy to lessen risk of obesity linked disease multicultural matters an investigation of key assumptions of multicultural education reform in teacher education multicultural awareness boosts teaching competency but is an uneven resource among future teachers nlrp attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth good bacteria is potential solution to unchecked inflammation seen in bowel diseases metabolic testing for adults in a state medicaid program receiving antipsychotics lipid testing underutilized in adults taking antipsychotic medications cannabinoid receptor signaling on hippocampal gabaergic neurons influences microglial activity vicious circle leads to loss of brain cells in old age exposure to airborne particulate matter during pregnancy is associated with preterm birth a population based cohort study exposure to high levels of air pollution associated with higher risk of preterm birth regulated virulence controls the ability of a pathogen to compete with the gut microbiota gut throat competition native bacteria fend off invaders suggesting new way to stop dangerous forms of e. coli a systems level analysis of the peripheral nerve intrinsic axonal growth program specific gene network found that promotes nervous system repair quantifying household waste of fresh fruit and vegetables in the eu eu households waste over billion kg of fresh fruit and vegetables a year maternal and fetal genomes interplay through phosphoinositol kinase pi k p signalling to modify placental resource allocation placenta plays pivotal umpire role to influence pregnancy outcomes radiation safety in children with congenital and acquired heart disease a scientific position statement on multimodality dose optimization from the image gently alliance lessening radiation risk for children with congenital and acquired heart disease neighborhood disadvantage poor social conditions and cardiovascular disease incidence among african american adults in the jackson heart study as neighborhood status falls cardiovascular disease risk among black residents spikes family history and outcome of young patients with breast cancer in the uk posh study family history of breast cancer doesn t mean a poor prognosis for women who develop the disease gestational exposure to volatile organic compounds vocs in northeastern british columbia canada a pilot study exposure to benzene during pregnancy a pilot study raises concerns in british columbia characterization of uptake and internalization of exosomes by bladder cancer cells study could aid in development of liquid biopsy screening diagnostic tests for bladder cancer household expenditure for dental care in low and middle income countries high costs of dental care leave many with too little money for basic necessities inhibition of pcsk with evolocumab in homozygous familial hypercholesterolaemia tesla part b a randomised double blind placebo controlled trial new drug achieves significant additional cholesterol lowering in people with inherited high cholesterol on statins modulation of longevity and tissue homeostasis by the drosophila pgc homolog fruit fly intestine may hold secret to fountain of youth long lived fruit flies offer clues to slowing human aging and fighting disease ecogenomics reveals metals and land use pressures on microbial communities in the waterways of a megacity scientists discover tiny microbes with potential to cleanse waterways cd v is a cancer specific marker for gastric cancer stem cells cancer specific cell identified for potential targeted treatment of gastric cancer changing the energy habitat of the cancer cell in order to impact therapeutic resistance turning up the heat to kill cancer cells the lance armstrong effect healthy eating in summer day camps the healthy lunchbox challenge healthy lunchbox challenge helps influence healthy eating habits in children integrating biogeochemistry with multiomic sequence information in a model oxygen minimum zone new model could point way to microbiome forecasting in the ocean principles to guide investment towards a stable climate new principles to guide corporate investment towards climate goals genetic analyses favour an ancient and natural origin of elephants on borneo new light on the mysterious origin of bornean elephants driving after drug or alcohol use by us high school seniors teen driving and marijuana use more than one in four high school seniors drive after using alcohol or drugs or ride with a driver who has sex life and impact of operative intervention on sex life related pain in degenerative spinal conditions surgery for back pain reduces problems with sex life related pain deletion of the imprinted gene grb promotes hematopoietic stem cell self renewal and regeneration genetic factors control regenerative properties of blood forming stem cells variants within the sp nuclear body protein modify risk of canine degenerative myelopathy second gene modifies effect of mutation in a dog model of als senataxin suppresses the antiviral transcriptional response and controls viral biogenesis new link between neurodegenerative diseases abnormal immune responses found cognitive enhancement therapy for adult autism spectrum disorder results of an month randomized clinical trial cognitive enhancement therapy improves outcomes for adults with autism the dominant role of extreme precipitation events in antarctic snowfall variability antarctic snowfall dominated by a few extreme snowstorms sitagliptin reduces inflammation and chronic immune cell activation in hiv adults with impaired glucose tolerance diabetes drug may reduce heart attack risk in hiv patients year assessment of fault leakage rates shows geological carbon storage is secure fault lines are no barrier to safe storage of carbon dioxide below ground food cue affected motor response inhibition and self reported dieting success a pictorial affective shifting task does food addiction exist ? research finds food addicts lacking psychological inhibition identification of new therapeutic targets for osteoarthritis through genome wide analyses of uk biobank data genetic study reveals possible new routes to treating osteoarthritis system wide rewiring underlies behavioral differences in predatory and bacterial feeding nematodes neurobiological consequence of predating or grazing in two worm species adverse events associated with opioid containing cough and cold medications in children research supports restrictions on opioid containing cold medicines for children stigmatizing attitudes toward persons with psoriasis among laypersons and medical students stigmatizing views and myths about psoriasis are pervasive in the united states pomalidomide augments fetal hemoglobin production without the myelosuppressive effects of hydroxyurea in transgenic sickle cell mice thalidomide analog appears worthy opponent of sickle cell disease who are sports gamers ? a large scale study of sports video game players video game users who are sports gamers ? place still matters racial ethnic and geographic disparities in hiv transmission and disease burden understanding connection between hiv transmission racial ethnic geographical differences risk and prognosis of cancer after lower limb arterial thrombosis three fold higher risk of cancer after acute thrombosis in the leg relationships between specific functional abilities and health related quality of life in chronic traumatic spinal cord injury quality of life after spinal cord injury what functional abilities have the greatest impact ? nicotine exposure of male mice produces behavioral impairment in multiple generations of descendants father s nicotine use can cause cognitive problems in children and grandchildren pets in airplane cabins an unnecessary allergic hazard pets in airplane cabins an unnecessary allergic hazard ? integration of geochemical and isotopic tracers for elucidating water sources and salinization of shallow aquifers in the sub saharan dr a basin morocco high salt levels in saharan groundwater endanger oases farming tinzaparin vs warfarin for treatment of acute venous thromboembolism in patients with active cancer study compares heparin to warfarin for treatment of blood clots in patients with cancer immune correlates analysis of an hiv vaccine efficacy trial rv vaccine efficacy increased against certain hiv viruses dominant point mutation in a tetraspanin gene associated with field evolved resistance of cotton bollworm to transgenic bt cotton genetic search reveals key to resistance in global cotton pest quantitative sd oct imaging biomarkers as indicators of age related macular degeneration progression retinal scan analysis can predict advance of macular degeneration study finds the mandibles of castrated male rhesus macaques macaca mulatta the effects of orchidectomy on bone and teeth low sex hormones could lead to oral health issues in men use of runx expression to identify osteogenic progenitor cells derived from human embryonic stem cells new reporter system to study bone related regenerative medicine generated health and work in the family evidence from spouses cancer diagnoses cancer in the family one spouse s diagnosis can lower household income five fold increase in national prevalence rates of attention deficit hyperactivity disorder medications for children and adolescents with autism spectrum disorder attention deficit hyperactivity disorder and other psychiatric disorders a danish registe five fold increase in adhd medication use in children and adolescents healthy infants harbor intestinal bacteria that protect against food allergy gut microbes from healthy infants block milk allergy development in mice carbon sequestration in an expanded lake system during the toarcian oceanic anoxic event prehistoric mega lake sediment offers key insight into how inland regions responded to super greenhouse event marine litter distribution and density in european seas from the shelves to deep basins european seafloor survey reveals depth of marine litter problem human embryonic stem cells derived by somatic cell nuclear transfer human skin cells converted into embryonic stem cells first time human stem cells have been produced via nuclear transfer warmer and wetter conditions will reduce offspring production of hawksbill turtles in brazil under climate change for these critically endangered marine turtles climate change could be a knockout blow scientific standards and the regulation of genetically modified insects available information on the free release of genetically modified insects into the wild is highly restricted precollege predictors of incapacitated rape among female students in their first year of college study finds high prevalence of incapacitated rape among college women an integrated genetic epigenetic analysis of schizophrenia evidence for co localization of genetic associations and differential dna methylation progress in refining the genetic causes of schizophrenia early pleistocene climate in western arid central asia inferred from loess palaeosol sequences palaeosol loess shed light on early pleistocene climate in western arid central asia a lectin isolated from bananas is a potent inhibitor of hiv replication chemical in bananas identified as potent inhibitor of hiv infection evaluation of mutant huntingtin and neurofilament proteins as potential markers in huntington s disease blood and brain fluid change first in huntington s disease detection of spontaneous tumorigenic transformation during culture expansion of human mesenchymal stromal cells screening for transformed human mesenchymal stromal cells with tumorigenic potential plant chip for high throughput phenotyping of arabidopsis instrument built to study effects of genes environment on plant traits developmental ethanol exposure induced sleep fragmentation predicts adult cognitive impairment sleep changes seen with fetal alcohol exposure partly explain learning mood problems impacts of classifying new york city students as overweight no dramatic shifts in bmi for overweight girls a year after receiving fitness assessment hepatic fibrosis is universal following fontan operation and severity is associated with time from surgery a liver biopsy and hemodynamic study all heart patients have some liver disease after fontan surgery activated pmn exosomes pathogenic entities causing matrix destruction and disease in the lung activated pmn exosomes are pathogenic entities that cause destruction in the copd lung dynamics of whale shark occurrence at their fringe oceanic habitat whale shark fringe migration year study suggests azore islands may play increasing role in whale shark habitat cerebral vascular amyloid seeds drive amyloid protein fibril assembly with a distinct anti parallel structure unique structure of brain blood vessel amyloid latest clue to alzheimer s development ? decreasing incidence and severity of cerebral palsy in prematurely born children decline in cerebral palsy diagnoses in premature infants suggests improvements in perinatal care geomorphic expression of rapid holocene silicic magma reservoir growth beneath laguna del maule chile ring around bathtub at giant volcano field shows movement of subterranean magma the association of lifetime physical inactivity with bladder and renal cancer risk a hospital based case control analysis sedentary lifestyle appears to increase risk for both kidney and bladder cancer an extensive reef system at the amazon river mouth scientists discover new reef system at mouth of amazon river risk factors for possible rem sleep behavior disorder kicking yelling during sleep ? study finds risk factors for violent sleep disorder crispr cas gene repair of hematopoietic stem cells from patients with x linked chronic granulomatous disease crispr gene editing takes on rare immunodeficiency disorder transcriptomic alterations in the brain of painted turtles chrysemys picta developmentally exposed to bisphenol a or ethinyl estradiol exposure to bpa potentially induces permanent reprogramming of painted turtles brains quasiparticle screening near a bosonic superconductor insulator transition revealed by magnetic impurity doping repelling charges prevent cooper pairs from island hopping in insulating state germline mc r status influences somatic mutation burden in melanoma red hair gene variation drives up skin cancer mutations association between transient newborn hypoglycemia and fourth grade achievement test proficiencya population based study association between transient newborn hypoglycemia th grade achievement social media financial algorithms and the hack crash with one false tweet computer based hack crash led to real panic inaugural article integrins and alpha are receptors for the rotavirus enterotoxin integrins as receptors give insight into rotavirus and diarrhea how might recharge change under projected climate change in the western u.s. ? groundwater recharge in the american west under climate change smoking is a major preventable risk factor for rheumatoid arthritis estimations of risks after various exposures to cigarette smoke smoking behind more than a third of severe rheumatoid arthritis cases lithium in the prevention of suicide in mood disorders updated systematic review and meta analysis lithium reduces risk of suicide in people with mood disorders review finds global contraction of antarctic bottom water between the s and s amount of coldest antarctic water near ocean floor decreasing for decades cheque cashing places preying on areas with high crime check cashing stores target areas with high crime machine learning to analyze the social ecological impacts of natural resource policy insights from community forest management in the indian himalaya machine learning detects importance of land stewardship in conservation policy impact of coverage dependent marginal costs on optimal hpv vaccination strategies urging hpv vaccine for boys could protect more people at same price mortality rates and cause of death patterns in a vaccinated population background mortality rates key to accurate reporting of vaccine safety risks development of a fiber optic optical coherence tomography probe for intraocular use needle sized imaging probe improves image quality surgical outcome isolation and identification of airborne fungi that can cause asthma a case study from eastern puerto rico airborne fungi linked to asthma epidemic in puerto rico lasting mantle scars lead to perennial plate tectonics deep scars from ancient geological events play role in current earthquakes eating patterns and overweight in to year old children in telemark county norway a cross sectional study overweight children have eating patterns different from those of normal weight children norwegian study finds willingness to pay and time trade off the burden of disease in patients with benign hyperpigmentation people with benign skin condition willing to trade time money to cure disorder atlantic bottlenose dolphins tursiops truncatus as a sentinel for exposure to mercury in humans closing the loop levels of mercury in dolphins linked to exposure in humans groundbreaking study finds ice vii inclusions in diamonds evidence for aqueous fluid in earth s deep mantle unique diamond impurities indicate water deep in earth s mantle fine mapping and identification of a candidate gene underlying the d dwarfing phenotype in pearl millet cenchrus americanus l. morrone gene responsible for short stature of dwarf pearl millet identified suppression of the vacuolar invertase gene prevents cold induced sweetening in potato gene suppression can reduce cold induced sweetening in potatoes dystroglycan suppresses notch to regulate stem cell niche structure and function in the developing postnatal subventricular zone muscular dystrophy causing receptor has broader role in brain development interpersonal body and neural synchronization as a marker of implicit social interaction social synchronicity research finds a connection between bonding and matched movements association between expiratory central airway collapse and respiratory outcomes among smokers airway disorder among smokers associated with worse respiratory quality of life long term mri follow up demonstrates minimal transitional level lumbar disc degeneration after posterior spine fusion for adolescent idiopathic scoliosis modern surgery for scoliosis has good long term outcomes study shows climate change and sugarcane expansion increase hantavirus infection risk climate change and sugarcane expansion expected to boost hantavirus cases early exposure to dogs and farm animals and the risk of childhood asthma early contact with dogs linked to lower risk of asthma a randomized controlled pilot trial of oral n acetylcysteine in children with autism antioxidant shows promise as treatment for certain features of autism rasgrp deficiency causes immunodeficiency with impaired cytoskeletal dynamics faulty rasgrp gene causes newly discovered human immunodeficiency human embryonic stem cell derived progenitors assist functional sensory regeneration after dorsal root avulsion injury recovery of sensory function by stem cell transplants a bio inspired imager improves sensitivity for near infrared fluorescence image guided surgery new camera inspired by butterfly eyes improves image guided cancer surgery from the cover the cheshire cat escape strategy of the coccolithophore emiliania huxleyi in response to viral infection cheshire cat escape strategy in response to marine viruses an animal to human scaling law for blast induced traumatic brain injury risk assessment new scaling law helps estimate humans risk of blast induced traumatic brain injury a confirmatory study of violence risk assessment tool m and demographic predictors of patient violence new aggression tool predicted violent patients in medical and surgical wards optimize energy efficiency of quadrotors via arm rotation up in arms insect inspired arm technology aims to improve drones computational diagnosis and risk evaluation for canine lymphoma new hope for beloved family pets new blood test for canine cancer extended year outcomes of accelerated partial breast irradiation using mammosite balloon brachytherapy patterns of failure patient selection and dosimetric correlates for late toxicity extended outcomes of adjuvant accelerated partial breast irradiation show excellent tumor control breast cosmesis minimal late toxicity an integrated computational model of the bone microenvironment in bone metastatic prostate cancer predicting therapy outcomes in prostate cancer with bone metastasis late pleistocene human genome suggests a local origin for the first farmers of central anatolia first anatolian farmers were local hunter gatherers that adopted agriculture cost effectiveness of preparticipation screening for prevention of sudden cardiac death in young athletes ecg testing of young athletes cost effective in preventing deaths study shows pharmacologic inhibition of cyclin dependent kinases and arrests the growth of glioblastoma multiforme intracranial xenografts targeted agent blocked growth of deadly brain cancer in preclinical studies association between longer therapy with thiazolidinediones and risk of bladder cancer a cohort study diabetes drugs prescribed to more than million americans raises risk of bladder cancer ultrasonic stimulation of mouse skin reverses the healing delays in diabetes and aging by activation of rac ultrasound accelerates skin healing especially for diabetics and the elderly a distinct sodium channel voltage sensor locus determines insect selectivity of the spider toxin dc a potent spider toxin electrocutes german not american cockroaches systemic aav gene therapy improves the lifespan of mice with niemann pick disease type c gene therapy shows promise for treating niemann pick disease type c india s abortion law puts women at risk india s abortion law puts women at risk should be changed experts say loss and recovery of genetic diversity in adapting populations of hiv evolution of drug resistance within a hiv population a model based approach to optimizing ms. pac man game strategies in real time engineers eat away at ms pac man score with artificial player wasp b kelt b joint discovery of a hot jupiter transiting a rapidly rotating f v star new hot jupiter marks the first collaborative exoplanet discovery rna sequencing of the human milk fat layer transcriptome reveals distinct gene expression profiles at three stages of lactation why some women don t have enough breastmilk for baby important role of insulin in making breast milk identified fruit and vegetable intakes are associated with lower risk of bladder cancer among women in the multiethnic cohort study higher intake of fruits and vegetables may reduce the risk of bladder cancer in women the origin of fast molecular outflows in quasars molecule formation in agn driven galactic winds newborns or survivors ? the unexpected matter found in hostile black hole winds cotrimoxazole prophylaxis discontinuation among antiretroviral treated hiv infected adults in kenya a randomized non inferiority trial hiv aids management trial shows importance of cotrimoxazole prophylaxis in malaria endemic regions a new scenario resource for integrated. c research new interactive scenario explorer for. degrees c pathways a preliminary study effects of football training on glucose control body composition and performance in men with type diabetes soccer for untrained year old men yields amazing results f av tau pet imaging correlates strongly with tau neuropathology inmaptmutation carriers new imaging technique in alzheimer s disease opens up possibilities for new drug development a tripartite complex of supar apol risk variants and v integrin on podocytes mediates chronic kidney disease catalyst for genetic kidney disease in black people identified tracing social interactions in pleistocene north america via d model analysis of stone tool asymmetry traces of adaptation and cultural diversification found among early north american stone tools erologic evidence of influenza a h n pdm virus in northern sea otters sea otters can get the flu too human h n pandemic virus infected washington state sea otters long term experimental hybridisation results in the evolution of a new sex chromosome in swordtail fish years of experimental evolution results in a new sex chromosome direct measurements of ice shelf flexure caused by surface meltwater ponding and drainage antarctic ice shelves buckle under weight of meltwater lakes atrx loss promotes tumor growth and impairs nonhomologous end joining dna repair in glioma new weapon in the fight against children s brain tumors taxonomic revision of the tarantula genus aphonopelma pocock araneae mygalomorphae theraphosidae within the united states new tarantula named after johnny cash among spider species found in the united states choline transporter like is required for sieve plate development to mediate long distance cell to cell communication botany developmental regulation of important plant phloem components discovered non biological factors affecting survival in younger patients with acute myeloid leukemia social factors may impact young leukemia patients survival performance of the immunochemical fecal occult blood test in predicting lesions in the lower gastrointestinal tract noninvasive fecal occult blood test effective screen for lower gi tract lesions evidence for the formation of comet p churyumov gerasimenko through gravitational collapse of a bound clump of pebbles comet mission reveals missing link in our understanding of planet formation effect of risk reduction counseling with rapid hiv testing on risk of acquiring sexually transmitted infections brief risk reduction counseling at hiv testing does not result in reduction of stis selective blockade of periostin exon preserves cardiac performance in acute myocardial infarction preventing of cardiac failure in the chronic phase prediction of late distant recurrence in patients with oestrogen receptor positive breast cancer a prospective comparison of the breast cancer index bci assay gene recurrence score and ihc in the transatac study population biomarker predicts long term risk of breast cancer recurrence perinatal bisphenol a exposure induces chronic inflammation in rabbit offspring via modulation of gut bacteria and their metabolites perinatal bpa exposure induces chronic inflammation by modulating gut bacteria a systematic review of vitamin d status in populations worldwide more than one third of populations worldwide may have low levels of vitamin d study shows the consequences of climate change at an avian influenza hotspot climate change could increase levels of avian influenza in wild birds deep cuts to india s health spending will delay universal access to healthcare spending cuts in india will hurt already inadequate health services experts say in vivo application of tissue engineered veins using autologous peripheral whole blood a proof of concept study making personalized blood vessels from a patient s blood sample paternal alcohol exposure reduces alcohol drinking and increases behavioral sensitivity to alcohol selectively in male offspring dad s alcohol consumption before conception could influence sons drinking ecotoxicological hazard and risk assessment of endocrine active substances international consensus on the environmental regulatory assessment of endocrine disrupting substance need for cognitive closure risk aversion uncertainty changes and their effect on investment decisions investment fears how does the need for closure increase risk ? the ultrafast dynamics and conductivity of photoexcited graphene at different fermi energies a boost for graphene based light detectors photoexcited graphene puzzle solved vortex arrays and ciliary tangles underlie the feeding swimming trade off in starfish larvae starfish larvae create complex water whorls to eat and run coralgal reef morphology records punctuated sea level rise during the last deglaciation fossil coral reefs show sea level rose in bursts during last warming an event related potential study of response inhibition in adhd with and without prenatal alcohol exposure neural processing differences in adhd in individuals with and without prenatal alcohol exposure using publicly available data to construct a transparent measure of health care value a method and initial results researchers develop new method to transparently measure health care value greater fructose consumption is associated with cardiometabolic risk markers and visceral adiposity in adolescents high levels of fructose consumption by adolescents may put them at cardiovascular risk evidence suggests symbolic equids and kushite state formation a horse burial at tombos archaeologists on ancient horse find in nile river valley communal nesting kinship and maternal success in a social primate nursery nests are better for survival of young black and white ruffed lemurs effectiveness and safety of long term treatment with sulfonylureas in patients with neonatal diabetes due to kcnj mutations an international cohort study researchers change clinical practice for infants with diabetes phthalates and thyroid function in preschool age children sex specific associations household chemicals may impair thyroid in young girls palliative radiation therapy for bone metastases update of an astro evidence based guideline radiation therapy continues to be gold standard for palliative care of painful bone metastases the effect of supplementation with alkaline potassium salts on bone metabolism a meta analysis potassium salts aid bone health limit osteoporosis risk new research finds comt and oprm genotype associations with daily knee pain variability and activity induced pain genetics influences knee pain sensitivity in osteoarthritis patients engineering a flux dependent mobility edge in disordered zigzag chains quantum simulation reveals mobility edge in a low dimensional disordered landscape intranasal delivery of a novel amnion cell secretome prevents neuronal damage and preserves function in a mouse multiple sclerosis model anti cell death agent a potential treatment for vision loss associated with ms using search engine data as a tool to predict syphilis researchers use search engines social media to predict syphilis trends harnessing liquid in liquid printing and micropatterned substrates to fabricate dimensional all liquid fluidic devices bridge over coupled waters scientists d print all liquid lab on a chip association of coprescription of triptan antimigraine drugs and selective serotonin reuptake inhibitor or selective norepinephrine reuptake inhibitor antidepressants with serotonin syndrome risk of serotonin syndrome in patients prescribed triptans for migraine antidepressants combined impacts of deforestation and wildlife trade on tropical biodiversity are severely underestimated underestimating combined threats of deforestation and wildlife trade will push southeast asian birds structural brain correlates of obstructive sleep apnoea in older adults at risk for dementia sleep disorder linked with changes to brain structure typical of dementia rhogdi suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration major study stops bladder cancer from metastasizing to lungs depression increases the risk of death independently from vascular events in elderly individuals the three city study depression increases risk of early death in older adults earthquake nucleation and fault slip complexity in the lower crust of central alaska scientists find pre earthquake activity in central alaska in situ ultra sensitive infrared absorption spectroscopy of biomolecule interactions in real time with plasmonic nanoantennas cross country collaboration leads to new leukemia model plasticity in thermal tolerance has limited potential to buffer ectotherms from global warming climate change could cause cold blooded animals thermal tolerance to shrink human bone marrow endothelial progenitor cell transplantation into symptomatic als mice delays disease progression and increases motor neuron survival by repairing blood spinal cord barrier transplanted bone marrow endothelial progenitor cells delay als disease progression label free raman spectroscopy reveals signatures of radiation resistance in the tumor microenvironment imaging technique finds differences between radiation sensitive and resistant tumors the relationship of motor skills and adaptive behavior skills in young children with autism spectrum disorders autistic children with better motor skills more adept at socializing sensory integration in mouse insular cortex reflects gaba circuit maturation insular cortex alterations in mouse models of autism trends in media reports of celebrities breast cancer treatment decisions media coverage of celebrities with breast cancer influencing rise in double mastectomy endothelial cation channel piezo controls blood pressure by mediating flow induced atp release sensor for blood flow discovered in blood vessels sites of origin of oral cavity cancer in nonsmokers vs smokers possible evidence of dental trauma carcinogenesis and its importance compared with human papillomavirus location of oral cancers differs in smokers nonsmokers the impact of a local smoke free air law on wagering at an off track betting facility in indiana smoke free air law had no effect on off track betting facility business activity indiana study finds replication stress is a potent driver of functional decline in ageing haematopoietic stem cells key to aging immune system discovery of dna replication problem brain enlargement and dental reduction were not linked in hominin evolution evolution of brain and tooth size were not linked in humans epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment zebrafish reveal drugs that may improve bone marrow transplant gender based disparities in infant and child mortality based on maternal exposure to spousal violence violence against mothers linked to. million female infant and child deaths in india alt an il superagonist in combination with nivolumab in patients with metastatic non small cell lung cancer a non randomised open label phase b trial new immunotherapy for lung cancer shows promise of success the rise of oxygen in earth s early ocean and atmosphere the ups and downs of early atmospheric oxygen infertility treatment and risk of severe maternal morbidity a propensity score matched cohort study infertility treatment linked with slightly higher risk of pregnancy complications biomechanics of tetrahymena escaping from a dead end microorganisms can escape from a dead end by swimming southward shift of the global wind energy resource under high carbon dioxide emissions a global north to south shift in wind power by end of century associations between household food insecurity in early childhood and children s kindergarten skills food insecurity in early childhood linked to young children s skills in kindergarten glycation altered proteolysis as a pathobiologic mechanism that links dietary glycemic index aging and age related disease in non diabetics amd like lesions delayed in mice fed lower glycemic index diet emerging adults treatment outcomes in relation to step mutual help attendance and active involvement young adults with addiction benefit from active twelve step group participation study suggests how statistical deception created the appearance that statins are safe and effective in primary and secondary prevention of cardiovascular disease no association between bad cholesterol and elderly deaths effect of smoking cessation intervention on results of acute fracture surgery a randomized controlled trial lucky break quit smoking after fracture surgery for better healing social justice and social determinants of health lesbian gay bisexual transgendered intersexed and queer youth in canada nurses critical in assuring health needs of lesbian gay bisexual transgendered intersexed and queer youth ppar antagonist aa triggers metabolic reprogramming and increases sensitivity to radiation therapy in human glioblastoma primary cells researchers slow glioblastoma by inhibiting tumor s ppara receptor ixekizumab for the treatment of patients with active psoriatic arthritis and an inadequate response to tumour necrosis factor inhibitors results from the week randomised double blind placebo controlled period of the spirit p phase trial drug for refractory psoriatic arthritis shows promise in clinical trial indoor air quality ventilation and respiratory health in elderly residents living in nursing homes in europe air quality in nursing homes affecting lung health of residents interactions between lithium growths and nanoporous ceramic separators whiskers surface growth and dendrites in lithium batteries hyperbaric oxygen treatment suppresses withdrawal signs in morphine dependent mice pure oxygen in high pressure chamber relieves symptoms of opiate withdrawal in mice rcan links impaired neurotrophin trafficking to aberrant development of the sympathetic nervous system in down syndrome research traces cause of organ dysfunction in down syndrome effects of recycled steel and polymer fibres on explosive fire spalling of concrete fibers from old tires can improve fire resistance of concrete rescue of obesity induced infertility in female mice due to a pituitary specific knockout of the insulin receptor a missing link from obesity to infertility researchers unravel clues to infertility among obese women reckless self destructive behavior and ptsd in veterans the mediating role of new adverse events reckless behavior fuels ongoing stress for some with ptsd modeling als with ipscs reveals that mutant sod misregulates neurofilament balance in motor neurons unraveling tangled origin of amyotrophic lateral sclerosis als coherent excitation of heterosymmetric spin waves with ultrashort wavelengths spintronics ultra short spin waves in an astoundingly simple material randomized controlled trial of minimally invasive sacroiliac joint fusion using triangular titanium implants vs nonsurgical management for sacroiliac joint dysfunction implant procedure helps patients with sacroiliac joint pain occupational exposure to volatile organic compounds and health risks in colorado nail salons colorado nail salon workers face chronic air pollution elevated cancer risk ets factors regulate neural stem cell depletion and gliogenesis in ras pathway glioma critical genes responsible for brain tumor growth identified whole genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial alzheimer s disease studying the outliers researchers discover a gene variant that provides a delaying mechanism for alzheimer s disease a low intake of antioxidant nutrients is associated with poor semen quality in patients attending fertility clinics semen quality may depend upon antioxidants in man s diet strength and geometry of the glacial atlantic meridional overturning circulation climate change circulation of atlantic ocean was faster during last ice age than today sedentary behavior is associated with coronary artery calcification in the dallas heart study sedentary lifestyle associated with coronary artery calcium researchers find a new mammal from the upper cretaceous turonian campanian galula formation southwestern tanzania rukwa rift basin project names new cretaceous mammal from east african rift system effects of theit s your game... keep it realprogram on dating violence in ethnic minority middle school youths a group randomized trial it s your game... keep it real reduces dating violence among minority youth the peptidomimetic vasotide targets two retinal vegf receptors and reduces pathological angiogenesis in murine and nonhuman primate models of retinal disease new peptide mimic prevents abnormal blood vessel growth and may lead to anti cancer drugs contribution of copy number variation to down syndrome associated atrioventricular septal defects clues to genetics of congenital heart defects emerge from down syndrome study combinatorial treatments that overcome pdgfr driven resistance of melanoma cells to v eb raf inhibition combo therapies tested to overcome drug resistance in melanoma patients the developmental basis for the recurrent evolution of deuterostomy and protostomy discovering the origin of the anus and mouth pain trajectories of nursing home residents nearing death serious pain afflicts a third of nursing home residents in last months of life long term efficacy of methylphenidate in enhancing attention regulation social skills and academic abilities of childhood cancer survivors childhood cancer survivors show sustained benefit from common adhd medication emotional problems among recent immigrants and parenting status findings from a national longitudinal study of immigrants in canada immigrant parents refugees face greater mental health challenges kids learning at risk arginase suppresses renal carcinoma progression via biosynthetic cofactor pyridoxal phosphate depletion and increased polyamine toxicity depleted metabolic enzymes promote tumor growth in kidney cancer late holocene sea level fall and turn off of reef flat carbonate production rethinking bucket fill and coral reef growth models small drop in sea level had big impact on southern great barrier reef neural mechanisms of a genomewide important psychosis variant schizophrenia and manic depressive disorder genetic variant impairs communication within brain temporal processing and context dependency in c. elegans response to mechanosensation timings and behavior influence worm s response to force a functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity high throughput platform enables activity mapping of emerging cancer drug targets evaluation of euthanasia techniques for an invertebrate species land snails succinea putris beer eases final moments for euthanized invertebrates study finds liquid crystal elastomer shell actuators with negative order parameter new method inverts the self assembly of liquid crystals the impact of peer social networks on adolescent alcohol use initiation extent of peer social networks influences onset of adolescent alcohol consumption refractory dissolved organic nitrogen accumulation in high elevation lakes lake tahoe research provides new insights on global change insect inspired sequential inspection strategy enables an artificial network of four neurons to estimate numerosity bees can count with small number of nerve cells in their brains research suggests rediscovery of aquilaria rostrata thymelaeaceae a species thought to be extinct and notes on aquilaria conservation in peninsular malaysia researchers rediscover aquilaria rostrata thought to have become extinct half vs full dose trivalent inactivated influenza vaccine age dose and sex effects on immune responses half dose flu shot appears to produce immune response in young healthy adults plant micrornas in larval food regulate honeybee caste development cross kingdom regulation of honeybee caste development by dietary plant mirnas gut inflammation provides a respiratory electron acceptor for salmonella clues to common food poisoning salmonella creates environment in human intestines to foster its own growth the relationship between deliberate practice and performance in sports a meta analysis sports practice accounts for just one percent of the performance differences among elite athletes addressing poaching in marine protected areas through voluntary surveillance and enforcement apathy towards poachers widespread in world s marine protected areas hesc differentiation toward an autonomic neuronal cell fate depends on distinct cues from the co patterning vasculature human stem cell model reveals molecular cues critical to neurovascular unit formation phase locked indistinguishable photons with synthesized waveforms from a solid state source laser like photons signal major step towards quantum internet musical intervention enhances infants neural processing of temporal structure in music and speech music improves baby brain responses to music and speech human oocytes reprogram adult somatic nuclei of a type diabetic to diploid pluripotent stem cells first disease specific human embryonic stem cell line by nuclear transfer distant invasive breast cancer recurrence risk in human epidermal growth factor receptor positive t a and t b node negative localized breast cancer diagnosed from to a cohort from an integrated health care delivery system risk of recurrence low in smallest her breast cancer tumors golden rice is an effective source of vitamin a golden rice an effective source of vitamin a social dominance is associated with individual differences in heart rate and energetic response to food restriction in female red deer personality differences in lean times red deer with dominant personalities pay a high price the toll like receptor ligand flagellin promotes asthma by priming allergic responses to indoor allergens bacterial protein in house dust spurs asthma study finds autism spectrum disorder and particulate matter air pollution before during and after pregnancy a nested case control analysis within the nurses health study ii cohort fine particulate air pollution linked with increased autism risk scaling of maximum observed magnitudes with geometrical and stress properties of strike slip faults maximum observed earthquake magnitudes along continental transform faults intra tumour diversification in colorectal cancer at the single cell level every bowel tumor and bowel cancer cell has unique genetic fingerprints psoriasis genome wide association study identifies susceptibility variants within lce gene cluster at q compromised skin barrier function plays a role in psoriasis development quantitative analysis of calcium phosphate nanocluster growth using time of flight medium energy ion scattering spectroscopy identifying an initial growth process of calcium phosphate pemetrexed and cisplatin for the treatment of advanced persistent or recurrent carcinoma of the cervix a limited access phase ii trial of the gynecologic oncology group cancer fighting cocktail demonstrates promising results as treatment for advanced cervical cancer high throughput high resolution mapping of protein localization in mammalian brain by in vivo genome editing new slendr technique protein labeling in developing brain by genome editing the vermiform appendix impacts the risk of developing parkinson s disease appendix identified as a potential starting point for parkinson s disease patterns of emergency department use among long stay nursing home residents with differing levels of dementia severity half of long stay nursing home residents go to hospital ed regardless of cognitive status federal regulatory oversight of us clinics marketing adipose derived autologous stem cell interventions insights from new fda draft guidance documents us clinics avoiding government oversight of stem cell treatments influenza a h n virus in swine at agricultural fairs and transmission to humans michigan and ohio usa pig to person spread of flu at fairs a continued concern development of a three dimensional bioengineering technology to generate lung tissue for personalized disease modeling stem cells grown into d lung in a dish probing quantum coherence in single atom electron spin resonance major discovery in controlling quantum states of single atoms circularly polarized light as a communication signal in mantis shrimps marine animals use new form of secret light communication high growth potential and nitrogen removal performance of marine anammox bacteria in shrimp aquaculture sediment treatment of nitrogen polluted sediment using marine anammox bacteria mental illness suicide and creativity year prospective total population study link between creativity and mental illness confirmed in large scale swedish study youth alcohol brand consumption and exposure to brand advertising in magazines underage drinkers heavily exposed to magazine ads for alcohol brands they consume prenatal exposure to binge pattern of alcohol consumption mental health and learning outcomes at age binge drinking in pregnancy can affect child s mental health school results increased crf signalling in a ventral tegmental area interpeduncular nucleus medial habenula circuit induces anxiety during nicotine withdrawal scientists identify brain circuitry responsible for anxiety in smoking cessation plant lectin can target receptors containing sialic acid exemplified by podoplanin to inhibit transformed cell growth and migration bioactive protein from ancient medicinal plant may help combat melanoma and other cancers high exercise capacity attenuates the risk of early mortality after a first myocardial infarction higher fitness linked to reduced risk of death after first heart attack water mass transformation by sea ice in the upper branch of the southern ocean overturning wind blown antarctic sea ice helps drive ocean circulation structural transformation identification of sputtered amorphous mosx as an efficient hydrogen evolving catalyst during electrochemical activation catalyst research for solar fuels amorphous molybdenum sulfide works best oxidative stress inhibits healthy adipose expansion through suppression of srebf mediated lipogenic pathway oxidative stress makes difference between metabolically abnormal and healthy obesities safety and efficacy of immunotherapy with the recombinant b cell epitope based grass pollen vaccine bm first vaccine in the world developed against grass pollen allergy sexual dimorphism in the tarsal bones implications for sex determination foot bones allow researchers to determine sex of skeletal remains long term heart specific mortality among breast cancer patients treated with radiotherapy or chemotherapy a registry based cohort study breast cancer therapy all clear for the heart multiple generations of grain aggregation in different environments preceded solar system body formation experiments trace interstellar dust back to solar system s formation inhibition of polo like kinase plk a new therapeutic option for rhabdoid tumors and pediatric medulloblastoma promising target for treating brain tumors in children exploratory study examining clinical measures of adiposity risk for predicting obesity in adolescents with physical disabilities current bmi tests underestimate obesity in teens with disabilities alternating current stimulation for vision restoration after optic nerve damage a randomized clinical trial current stimulation to the brain partially restores vision in patients with glaucoma and optic nerve damage urocanic acid modified chitosan nanoparticles can confer anti inflammatory effect by delivering cd sirna to macrophages nanoparticles show promise for treating intestinal inflammation study finds sensitivity to sunk costs in mice rats and humans sunk cost fallacy in mice rats and humans change in international normalized ratio among patients treated with dicloxacillin and vitamin k antagonists antibiotic use and decrease in inr levels among patients taking vitamin k antagonists temperature dependent adaptation allows fish to meet their food across their species range adult fish predict availability of food for their young active host response to algal symbionts in the sea slug elysia chlorotica solar powered sea slugs shed light on search for perpetual green energy association of the breast cancer antiestrogen resistance protein bcar and bcar scaffolding proteins in cell signaling and antiestrogen resistance proteins conspire to make breast cancer cells resistant to drug treatment short term effects of air pollution on a range of cardiovascular events in england and wales case crossover analysis of the minap database hospital admissions and mortality air pollution linked to irregular heartbeat lung blood clots visceral fat is a negative predictor of bone density measures in obese adolescent girls different fat types can help or hinder obese girls bone health the unique sound production of the death s head hawkmoth acherontia atropos linnaeus revisited fluttering accordion new study explains unique sound production by death s head hawkmoths dominance of the suppressed power law size structure in tropical forests in rainforests battle for sunlight shapes forest structure breast cancer risk after use of fertility drugs stimulating new controversy unsuccessful fertility drug users have reduced breast cancer risk study suggests intestinal autophagy improves healthspan and longevity in c. elegans during dietary restriction dietary restriction increases lifespan through effects on the gut canine babesiosis and tick activity monitored using companion animal electronic health records in the uk canine babesiosis outbreak in uk under control but needs monitoring inherited mutations in cancer susceptibility genes are common among breast cancer survivors who develop therapy related leukemia characteristics that may increase a breast cancer survivor s risk of developing leukemia following treatment identified teacher assessments during compulsory education are as reliable stable and heritable as standardized test scores teachers predict pupil success just as well as exam scores o glcnac signaling orchestrates the regenerative response to neuronal injury in caenorhabditis elegans better understanding of potential regeneration after brain spinal cord injury one year seismic hazard forecast for the central and eastern united states from induced and natural earthquakes forecast significant chance of earthquake damage in the central and eastern us reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells making sperm from stem cells in a dish global goods movement and the local burden of childhood asthma in southern california big air pollution impacts on local communities traffic corridors major contributors to illness from childhood asthma malignancies associated with tumour necrosis factor inhibitors in registries and prospective observational studies a systematic review and meta analysis biological agents for rheumatoid arthritis associated with increased skin cancer risk review finds ultra rare genetic variation in common epilepsies a case control sequencing study common epilepsies share genetic overlap with rare types deep reefs are not universal refuges reseeding potential varies among coral species deep reefs unlikely to save shallow coral reefs musashi attenuates ahr signalling to expand human haematopoietic stem cells scientists uncover new way to grow rare life saving blood stem cells voluntary family planning to minimise and mitigate climate change expert urges voluntary family planning to mitigate climate change intestinal microbiota promote enteric virus replication and systemic pathogenesis research could lead to new treatments for inflammatory bowel disease ibd and viral infections the use of donation after cardiac death allografts does not increase recurrence of hepatocellular carcinoma livers donated after cardiac death are safe to use in liver cancer patients on a transplant list exploring the physical limits of saturation contrast in magnetic resonance imaging visualizing the matrix app provides insight into the quantum world of coupled nuclear spins onj in two dental practice based research network regions commonly prescribed osteoporosis drug associated with very low risk of serious jaw disease an hiv vaccine is essential for ending the hiv aids pandemic durable end to the hiv aids pandemic likely will require an hiv vaccine promising parenting programmes for reducing adolescent problem behaviours five most effective parenting programs to reduce problem behaviors in teens disparities in endometrial cancer outcomes between non hispanic white and hispanic women hispanic women less likely to survive endometrial uterine cancer inflammaging increases susceptibility to cigarette smoke induced copd age related inflammatory processes facilitate development of copd survival rates in trauma patients following health care reform in massachusetts survival rates in trauma patients after massachusetts health insurance reform evaluating the impact of the us national hiv aids strategy number of hiv infections falling in united states but fails to meet reduction goals understanding the fuel savings potential from deploying hybrid cars in china hybrid vehicles more fuel efficient in india china than in u.s. premarket safety and efficacy studies for adhd medications in children review of adhd drug approvals highlights gaps between approval process long term safety assessment experiments with seasonal forecasts of ocean conditions for the northern region of the california current upwelling system ocean forecast offers seasonal outlook for pacific northwest waters revision rates and risk factors of patients undergoing septorhinoplasty revision rates patient characteristics in those undergoing septorhinoplasty implications of land use land cover dynamics and prosopis invasion on ecosystem service values in afar region ethiopia massive ecological and economic impacts of woody weed invasion in ethiopia signals of sedentism faunal exploitation as evidence of a delayed return economy at norje sunnansund an early mesolithic site in south eastern sweden fish selective hunting strategies and a delayed return lifestyle among ancient foragers farm dust and endotoxin protect against allergy through a induction in lung epithelial cells growing up on a farm provides protection against asthma and allergies rapid termination of the african humid period triggered by northern high latitude cooling cooling in high and mid latitudes led to aridification in northern africa a gp src yap module links inflammation to epithelial regeneration link between inflammation tissue regeneration and wound repair response global burden of stroke and risk factors in countries during a systematic analysis for the global burden of disease study for the first time air pollution emerges as a leading risk factor for stroke worldwide detecting mild traumatic brain injury using resting state magnetoencephalographic connectivity high resolution brain scans could improve concussion detection effect of chaiqinchengqi decoction on sarco endoplasmic reticulum ca atpase mrna expression of pancreatic tissues in acute pancreatitis rats promising chinese herbal targets identified for acute pancreatitis psychological and school functioning of latino siblings of children with intellectual disability latino siblings of children with developmental disabilities at risk study finds control of dynamic limb motion using fatigue resistant asynchronous intrafascicular multi electrode stimulation precise nerve stimulation via electrode implants offers new hope for paralysis patients age legislation and off road vehicle injuries in children massachusetts off road vehicle law significantly reduces injuries hospitalizations in children conversational topic moderates social attention in autism spectrum disorder talking about emotions is like driving in a snowstorm new study adds key piece to autism puzzle effect of vascular risk factors and diseases on mortality in individuals with dementia a systematic review and meta analysis diabetes heart disease smoking increase risk of death for older adults with dementia restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling controlling a single brain chemical may help expand window for learning language and music a human pluripotent stem cell based screen for smooth muscle cell differentiation and maturation identifies inhibitors of intimal hyperplasia stem cell scientists clear another hurdle in creating transplant arteries relation between statewide hospital performance reports on myocardial infarction and cardiovascular outcomes repeat heart attack and early death linked to hospitals with low care scores home based versus office based biofeedback therapy for constipation with dyssynergic defecation a randomised controlled trial home based biofeedback therapy is effective option for tough to treat constipation social competence sense of loneliness and speech intelligibility of young children with hearing loss in individual inclusion and group inclusion speaking skills crucial for hearing impaired children in the classroom the global burden of occupationally related low back pain estimates from the global burden of disease study low back pain accounts for third of all disability linked to work overdiagnosis in mammography screening a year journey from shadowy idea to acknowledged reality agreement on best estimates of breast cancer overdiagnosis urgently needed to inform women evidence suggests that the acas tobacco surcharges reduced insurance take up and did not increase smoking cessation aca s tobacco surcharges reduce smokers insurance take up study finds consumption of added sugars and indicators of cardiovascular disease risk among us adolescents high sugar consumption may increase risk factors for heart disease in american teenagers blockade of the katp channel kir. by memantine represents a novel mechanism relevant to alzheimer s disease therapy alzheimer s disease found to be a diabetic disorder of the brain estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue new computer model sheds light on biological events leading to sudden cardiac death antidepressant use during pregnancy and the risk of major congenital malformations in a cohort of depressed pregnant women an updated analysis of the quebec pregnancy cohort new data show heightened risk of birth defects with antidepressants prescribed during pregnancy sexual risk behavior among virologically detectable human immunodeficiency virus infected young men who have sex with men risky sexual behavior by young men with hiv who have sex with men trpv mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles findings on pollution damage to human airways could yield new therapies refined ordovician timescale reveals no link between asteroid breakup and biodiversification myth busted no link between gigantic asteroid break up rise in biodiversity hiv pre exposure prophylaxis prep in the united states impact on lifetime infection risk clinical outcomes and cost effectiveness model of pre exposure prophylaxis against hiv forecasts benefits potential cost effectiveness human plasma metabolomics study across all stages of age related macular degeneration identifies potential lipid biomarkers researchers identify potential biomarkers of age related macular degeneration false blister beetles and the expansion of gymnosperm insect pollination modes before angiosperm dominance mid mesozoic beetle in amber stirs questions on rise of flowering plants and pollinators anti inflammatory efficiency of levobupivacaine in an experimental colitis model use of local anesthetics in the treatment of inflammatory bowel disease sharps injuries the risks and relevance to plastic surgeons sharps injuries have major health and cost impact for surgeons oncogenic pi k promotes methionine dependency in breast cancer cells through the cystine glutamate antiporter xct mechanism behind metabolic vulnerability of some breast cancers quantifying relative fish abundance with edna a promising tool for fisheries management researchers measure fish abundance in a lake using a few water samples heart rate variability a risk factor for female sexual dysfunction lower resting heart rate variability linked with sexual difficulties in women does war hurt ? effects of media exposure after missile attacks on chronic pain viewing media coverage of terrorist attacks causes an increase in chronic pain intensity genomic landscape of ewing sarcoma defines an aggressive subtype with co association of stag and tp mutations gene sequencing projects link two mutations to ewing sarcoma subtype with poor prognosis population based assessment of complications following surgery for thyroid cancer complications from thyroid cancer surgery more common than believed study finds liver injury from herbals and dietary supplements in the u.s. drug induced liver injury network liver injury caused by herbals dietary supplements rises in study population nationwide trends in mastectomy for early stage breast cancer study finds gaps in patient knowledge of breast reconstruction surgery complications hallmarks of alzheimer s disease in stem cell derived human neurons transplanted into mouse brain human neurons in mouse brains are more susceptible to alzheimer s pathology strategies for improved hospital response to mass casualty incidents new strategies for hospitals during mass casualty incidents environmental and genetic control of brain and song structure in the zebra finch like father not like son brain and song structure in zebra finches are strongly influenced by the environment speleothem records of glacial interglacial climate from iran forewarn of future water availability in the interior of the middle east stalagmites from iranian cave foretell grim future for middle east climate donor derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient case report of a brain and spinal tumor following human fetal stem cell therapy interactions between adipocytes and breast cancer cells stimulate cytokine production and drive src sox mir b mediated malignant progression breast cancer has a higher incidence in obese women because fat facilitates cancer stem cells expansion delayed onset post traumatic stress disorder symptoms in dementia some patients with dementia may experience delayed onset ptsd most fish destined for fishmeal production are food grade fish percent of fish used for fishmeal are prime fish opioid prescribing at hospital discharge contributes to chronic opioid use researchers find new risk posed by opioid pain medication the raccoon dog nyctereutes procyonoides and the raccoon procyon lotor their role and impact of maintaining and transmitting zoonotic diseases in austria central europe raccoon dog represents a more acute risk than raccoon as vector for transmission of local parasites register data suggest lower intelligence in men born the year after flu pandemic prenatal exposure to hong kong flu associated with reduced intelligence in adulthood measuring rates of herbicide metabolism in dicot weeds with an excised leaf assay new method developed for testing herbicide resistance in weeds association of blood pressure blood glucose and temperature with neurological outcome after childhood stroke are childhood stroke outcomes associated with bp blood glucose temperature ? metabolic profiling distinguishes three subtypes of alzheimer s disease alzheimer s disease consists of three distinct subtypes according to study time resolved electrostatic force microscopy using tip synchronized charge generation with pulsed laser excitation high speed surveillance in solar cells catches recombination red handed white blood cell brca promoter methylation status and ovarian cancer risk normal tissue brca methylation associated with risk for high grade ovarian cancer the art of rock relief in ancient arabia new evidence from the jawf province rock art life sized sculptures of dromedaries found in saudi arabia phylogenetic analysis of the genus laparocerus with comments on colonisation and diversification in macaronesia coleoptera curculionidae entiminae champions of biodiversity weevil genus beats records of explosive evolutive radiation large scale meta analysis of genome wide association data identifies six new risk loci for parkinson s disease six new genetic risk factors for parkinson s found insar based mapping of tidal inundation extent and amplitude in louisiana coastal wetlands new study shows impact of human made structures on louisiana s coastal wetlands cell culture based influenza vaccine manufacturing evaluation of near infrared spectroscopy for in line determination of virus titers near infrared spectroscopy could improve flu vaccine manufacturing high dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy benefits of high dose vitamin c for ovarian cancer patients predatory fish invasion induces within and across ecosystem effects in yellowstone national park broad impacts from lake trout invasion in yellowstone smokers perceptions of risks and harm from snus relative to cigarettes a latent profile analysis study smokers often misunderstand health risks of smokeless tobacco product study finds headache the placebo effects in the control groups in randomized clinical trials an analysis of systematic reviews all in your head ? substantial recovery rate with placebo effect in headache treatment analysis finds dysregulated microbial fermentation of soluble fiber induces cholestatic liver cancer adding refined fiber to processed food could have negative health effects study finds impact of current antipsychotic medications on comparative mortality and adverse events in people with parkinson disease psychosis antipsychotics increase risk of death in people with parkinson s disease psychosis battery free electronic smart toys a step toward the commercialization of sustainable triboelectric nanogenerators battery free smart toys move closer to commercial reality therapeutic silencing of fat specific protein improves glycemic control in mouse models of obesity and insulin resistance silencing fat protein improves obesity and blood sugar a potential wound healing promoting peptide from salamander skin salamander skin peptide promotes quick effective wound healing in mice prevalence of teen driver errors leading to serious motor vehicle crashes study pinpoints common critical errors in teen crashes genotype phenotype correlation in nf evidence for a more severe phenotype associated with missense mutations affecting nf codons a cluster of mutations in neurofibromatosis is an important risk factor for severe symptoms three decades of follow up of adults after recovery from invasive pneumococcal pneumonia shortened lifespan for survivors of invasive pneumococcal pneumonia study shows crimean congo hemorrhagic fever virus entry into host cells occurs through the multivesicular body and requires escrt regulators research milestone in cchf virus could help identify new treatments firearm possession among adolescents presenting to an urban emergency department for assault gunning for trouble guns and aggression in young assault victims assessment of the emotional responses produced by exposure to real food virtual food and photographs of food in patients affected by eating disorders virtual food causes stress in patients affected by eating disorders the vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs why a whiff of cats or rats is scary chemical signal from predators sparks fear in mice cancer screening in the united states a review of current american cancer society guidelines and current issues in cancer screening american cancer society endorses two dose regimen for hpv vaccination the susceptibility of southeastern amazon forests to fire insights from a large scale burn experiment decade long amazon rainforest burn yields new insight into wildfires cholinergic signaling controls conditioned fear behaviors and enhances plasticity of cortical amygdala circuits manipulation of specific neurons helps to erase bad memories enhance good ones gender differences of young drivers on injury severity outcome of highway crashes young driver s gender linked to crash type injury severity fast radio bursts the observational case for a galactic origin astronomers propose a cell phone search for galactic fast radio bursts maintaining tiger connectivity and minimizing extinction into the next century insights from landscape genetics and spatially explicit simulations protecting corridors is critical to preserving genetic diversity in tigers and mizimising extinction study finds compliance with evidence based guidelines and interhospital variation in mortality for patients with severe traumatic brain injury compliance with guidelines for treating brain injuries doesn t guarantee better outcomes small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor oct molecular cocktail transforms skin cells into beating heart cells whitened resumes race and self presentation in the labor market even diversity friendly employers discriminate against racial minority job seekers abuse and subclinical cardiovascular disease among midlife women the study of women s health across the nation sexual abuse in childhood linked to signs of atherosclerosis in midlife an ultrafast nickel iron battery from strongly coupled inorganic nanoparticle nanocarbon hybrid materials scientists spark new interest in the century old edison battery enhanced boiling heat transfer using self actuated nanobimorphs new concept to cool boiling surface may help prevent nuclear power plant accidents systematics of ecnomiohyla tuberculosa with the description of a new species and comments on the taxonomy of trachycephalus typhonius anura hylidae disentangling the myth of the singing bushmaster viper with the help of tree frogs c orf rela fusions drive oncogenic nf b signalling in ependymoma gene sequencing project discovers common driver of a childhood brain tumor colonic mucosal dna methylation immune response and microbiome patterns in toll like receptor knockout mice microbes in our gut regulate genes that control obesity and inflammation extreme high high density lipoprotein cholesterol is paradoxically associated with high mortality in men and women two prospective cohort studies high levels of good cholesterol linked to excessive mortality effect of acupuncture vs sham acupuncture on live births among women undergoing in vitro fertilization a randomized clinical trial fertility study finds acupuncture ineffective for ivf birth rates geomagnetically induced currents science engineering and applications readiness living with a star nasa and partners survey space weather science basolateral amygdala regulation of adult hippocampal neurogenesis and fear related activation of newborn neurons fear boosts activation of immature brain cells adult neural stem cells play role in creating emotional context of memory a genome scan for loci shared by autism spectrum disorder and language impairment scientist identify genetic link between language impairment autism evaluation of emotion processing in hiv infected patients and correlation with cognitive performance ability to recognize emotions in others impaired by aids construction of an infectious horsepox virus vaccine from chemically synthesized dna fragments creation of synthetic horsepox virus could lead to more effective smallpox vaccine global gradients of coral exposure to environmental stresses and implications for local management worldwide map identifies important coral reefs exposed to stress the relationship between alcohol taxes and binge drinking evaluating new tax measures incorporating multiple tax and beverage types alcohol taxes protective against binge drinking study shows gene expression in response to optical defocus of opposite signs reveals bidirectional mechanism of visually guided eye growth gene changes driving myopia reveal new focus for drug development a clinically validated diagnostic second generation sequencing assay for detection of hereditary brca and brca mutations new diagnostic test for detecting brca and brca mutations ccl driven inflammation increases mammary gland stromal density and cancer susceptibility in a transgenic mouse model breast density research edges closer to cancer prevention identifying anticipated barriers to help seeking to promote earlier diagnosis of cancer in great britain receptionists could put people off seeing their gp roxarsone inorganic arsenic and other arsenic species in chicken a u.s. based market basket sample poultry drug increases levels of toxic arsenic in chicken meat expression of human leukocyte antigen class i in endocrine and exocrine pancreatic tissue at onset of type diabetes new study challenges link between hla class i hyperexpression in pancreas type diabetes sedentary behaviors tv viewing time and risk of young onset colorectal cancer sitting watching tv linked to colorectal cancer risk before age new study shows characterization of the direct targets of foxo transcription factors throughout evolution in wide range of species longevity proteins affect dozens of the same genes association between contemporary hormonal contraception and ovarian cancer in women of reproductive age in denmark prospective nationwide cohort study newer contraceptive pills linked to reduced ovarian cancer risk in young women radiosurgery to the postoperative tumor bed for metastatic carcinoma versus whole brain radiation after surgery targeted radiosurgery better than whole brain radiation for treating brain tumors antimicrobial spray nanocoating of supramolecular fe iii tannic acid metal organic coordination complex applications to shoe insoles and fruits material independent nanocoating antimicrobial spray extends the shelf life of produce beyond krabbe s disease the potential contribution of galactosylceramidase deficiency to neuronal vulnerability in late onset synucleinopathies rare genetic condition may provide insights on parkinson s and other late onset diseases identification of a tissue restricted isoform of sirt defines a regulatory domain that encodes specificity unraveling the functional diversity of longevity gene sirt cancer related cognitive outcomes among older breast cancer survivors in the thinking and living with cancer study first large study details cognitive outcomes among older breast cancer patients factors predicting inhaled corticosteroid responsiveness in african american patients with asthma no link between genetic ancestry asthma response in african americans study finds maternal hyperglycemia activates an ask foxo a caspase pathway that leads to embryonic neural tube defects new approach to prevent diabetes induced birth defects ? unravelling the molecular determinants of bee sensitivity to neonicotinoid insecticides breakthrough could aid development of bee friendly pesticides a children s oncology group and target initiative exploring the genetic landscape of wilms tumor comprehensive genomic analysis offers insights into causes of wilms tumor development the development of children placed into different types of russian families following an institutional intervention. the importance of loving care within children s institutions governments as partners the role of alliances in u.s. cleantech startup innovation green tech startups see boost in patents and investment when partnering with government germline brca mutations are associated with higher risk of nodal involvement distant metastasis and poor survival outcomes in prostate cancer first genetic factor in prostate cancer prognosis identified generation of transgenic plants expressing antibodies to the environmental pollutant microcystin lr genetically engineered tobacco plant cleans up environmental toxin sleep disruption impairs haematopoietic stem cell transplantation in mice sleep deprivation affects stem cells reducing transplant efficiency study finds enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience boosting depression causing mechanisms in brain increases resilience surprisingly web based alcohol screening and brief intervention for university students web based alcohol screening program shows limited effect among university students bodipy based fluorescent probes for sensing protein surface hydrophobicity neurodegenerative diseases the case of the sticky protein rnai mediated double gene knockdown and gustatory perception measurement in honey bees apis mellifera honey bee gene targeting offers system to understand food related behavior unpacking the impact of adverse childhood experiences on adult mental health childhood spankings can lead to adult mental health problems yelp reviews of hospital care can supplement and inform traditional surveys of the patient experience of care yelp reviews can enhance government reports on hospital quality study suggests oral immunotherapy in children with ige mediated wheat allergy towards a new wheat allergy treatment for children strength of association between umbilical cord ph and perinatal and long term outcomes systematic review and meta analysis low umbilical cord ph at birth linked to death and brain damage first six dimensional phase space measurement of an accelerator beam first particle accelerator beam measurement in six dimensions adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci obesity amplifies genetic risk of nonalcoholic fatty liver disease expanding utilization and regional coverage of diagnostic ct colonography early medicare claims experience nationwide utilization of virtual colonoscopy triples study suggests propagating wave of erk activation orients collective cell migration discovery of a mechanism for determining the direction of collective cell migration earliest signs of life on land preserved in ca.. ga hot spring deposits oldest evidence of life on land found in. billion year old australian rocks influence of high latitude atmospheric circulation changes on summertime arctic sea ice rapid decline of arctic sea ice a combination of climate change and natural variability strong whistler mode waves observed in the vicinity of jupiter s moons million fold increase in the power of waves near jupiter s moon ganymede onabotulinumtoxina vs sacral neuromodulation on refractory urgency urinary incontinence in women a randomized clinical trial study compares treatments for urinary incontinence in women degeneration of the knee joint in skeletally immature patients with a diagnosis of an anterior cruciate ligament tear is there harm in delay of treatment ? delay in surgery can cause irreparable meniscus tears in children with acl injuries high fat diet increases nf b signaling in the prostate of reporter mice mechanism for link between high fat diet and risk of prostate cancer and disorders unveiled comparison of secondary and primary thyroid cancer in adolescents and young adults secondary thyroid cancer more deadly than primary malignancy in young individuals exome sequencing of extreme phenotypes identifies dctn as a modifier of chronic pseudomonas aeruginosa infection in cystic fibrosis exome sequencing of health condition extremes can reveal susceptibility genes high resolution isotopic evidence of specialised cattle herding in the european neolithic isotopes in prehistoric cattle teeth suggest herding strategies used during the neolithic retinal degeneration in a mouse model of cln disease is associated with compromised autophagy photoreceptor cell death leads to blindness in cln form of neuronal ceroid lipofuscinosis automated hypothesis generation based on mining scientific literature promise in automated reasoning hypothesis generation over complete medical literature climate change may affect fatal competition between two bird species for these birds climate change spells a rise in fatal conflicts fertility preservation in young women with epithelial ovarian cancer young early stage ovarian cancer patients can preserve fertility colonoscopic screening in average risk individuals ages to vs to years colon cancer screening sooner ? prevalence of pre cancerous masses in colon same in patients in their s and s dynamic band structure tuning of graphene moir superlattices with pressure researchers control the properties of graphene transistors using pressure statins and all cause mortality in high risk primary prevention a meta analysis of randomized controlled trials involving participants report examines whether statins prevent death in high risk individuals without heart disease medicines for the mind policy based pull incentives for creating breakthrough cns drugs betting on brain research experts review challenges of translational neuroscience tropism intracerebral distribution and transduction efficiency of hiv and siv based lentiviral vectors after injection into the mouse brain a qualitative and quantitative in vivo study viral vectors for gene transfer travel longer distances in the brain than thought exposure to the functional bacterial amyloid protein curli enhances alpha synuclein aggregation in aged fischer rats and caenorhabditis elegans study demonstrates role of gut bacteria in neurodegenerative diseases single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma myeloma tumor cells profiling a killer in warm blood north pacific intermediate water circulation enhanced by the closure of the bering strait formation of coastal sea ice in north pacific drives ocean circulation climate potential benefits of minimum unit pricing for alcohol versus a ban on below cost selling in england modelling study minimum alcohol pricing would be up to times more effective than below cost selling ban cryo em structure of a native fully glycosylated cleaved hiv envelope trimer new tsri study shows hiv structure in unprecedented detail the immune microenvironment confers resistance to map kinase pathway inhibitors through macrophage derived tnf calming down immune cells could hold key to melanoma treatment hsv remodels host telomeres to facilitate viral replication herpes virus rearranges telomeres to improve viral replication cognition depressive symptoms and vascular factors among southwest tribal elders researchers find moderate vascular risk in southwest native population in vitro enteroid derived three dimensional tissue model of human small intestinal epithelium with innate immune responses stem cell derived intestine model mimics innate immune responses machine learning reveals cyclic changes in seismic source spectra in geysers geothermal field applying machine learning tools to earthquake data offers new insights the corallivorous flatworm amakusaplana acroporae an invasive species threat to coral reefs ? devil in disguise small coral eating worm may mean big trouble for reefs fructose in breast milk is positively associated with infant body composition at months of age from mother to baby secondhand sugars can pass through breast milk improved behavior and sleep after adenotonsillectomy in children with sleep disordered breathing removal of tonsils and adenoids associated with ongoing benefits for children with breathing problems during sleep diet induced lethality due to loss of hdac in heart and skeletal muscle high fat diet and lack of enzyme can lead to heart disease in mice yangtze dams increasingly threaten the survival of the chinese sturgeon yangtze dams put endangered sturgeon s future in doubt association between soft drink consumption and asthma and chronic obstructive pulmonary disease among adults in australia drinking large amounts of soft drinks associated with asthma and copd association between lymph node ratio and recurrence and survival outcomes in patients with oral cavity cancer lymph node ratio may predict who lives and dies from oral cavity cancer resolving biodegradation patterns of persistent saturated hydrocarbons in weathered oil samples from thedeepwater horizondisaster deepwater horizon identifying harmful elements of persisting oil evidence of marine ice cliff instability in pine island bay from iceberg keel plough marks scars left by icebergs record west antarctic ice retreat structure and function of the global ocean microbiome new insights into global ocean microbe virus interactions drivers of earth s ecosystems elevated levels of the reactive metabolite methylglyoxal recapitulate progression of type diabetes diabetes are high blood glucose levels an effect rather than the cause of the disease ? zika virus has oncolytic activity against glioblastoma stem cells zika virus could be used to treat brain cancer patients study suggests persistent postmastectomy pain in breast cancer survivors analysis of clinical demographic and psychosocial factors postmastectomy pain most troubling problem for breast cancer survivors clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development colorful clones researchers track development behavior of individual blood stem cells high prevalence of amblyopia risk factors in preverbal children with nasolacrimal duct obstruction kids with blocked tear ducts at higher risk for lazy eye amphibian distribution in a traditionally managed rural landscape of eastern europe probing the effect of landscape composition modern european agriculture jeopardizes biodiversity ? romanian study highlights importance of traditional agriculture in protecting amphibians improved healing of large segmental defects in the rat femur by reverse dynamization in the presence of bone morphogenetic protein simple inexpensive way to improve healing after massive bone loss understanding health related quality of life in adult women with metastatic cancer who have dependent children for mothers with advanced cancer parenting concerns affect emotional well being connectivity and the development of population genetic structure in indo west pacific coral reef communities coral network can protect asia pacific fish stocks study suggests trends in smoking initiation in europe over years a retrospective cohort study mixed trends in teenage new smoker rates in europe carbon depleted outer core revealed by sound velocity measurements of liquid iron carbon alloy liquid acoustics half way to the earth s core atopic dermatitis and risk of hypertension type diabetes myocardial infarction and stroke in a cross sectional analysis from the canadian partnership for tomorrow project study casts doubt about link between eczema cardiovascular disease variable quality and readability of patient oriented websites on colorectal cancer screening answering the call for quality colorectal cancer patient info diet may drive influenza a virus exposure in african mammals diet may be a key factor for influenza a virus exposure in wild african mammals the aftermath of workplace violence among healthcare workers a systematic literature review of the consequences workplace violence in the health sector what are the consequences ? the genetic basis of host preference and resting behavior in the major african malaria vector anopheles arabiensis mosquito preference for human versus animal biting has genetic basis internet and in person cognitive behavioral therapy for insomnia in military personnel a randomized clinical trial online cognitive behavioral therapy for insomnia is effective for military enso teleconnections to the indian summer monsoon in observations and models climate experts help communities cope with impact of the indian monsoon identifying targets for potential interventions to reduce rural trauma deaths a population based analysis more than percent of injury related deaths in rural ontario occur before patients reach hospital zic expression in planarian neoblasts after injury controls anterior pole regeneration gene discovered that activates stem cells for organ regeneration in planarians reproductive failure of a human tolerant species the american kestrel is associated with stress and human disturbance kestrels other urban birds are stressed by human activity misfolded mutant sod directly inhibits vdac conductance in a mouse model of inherited als neuron damaging mechanism discovered in mouse model of inherited als pharmacodynamics of mutant idh inhibitors in glioma patients probed by in vivo d mrs imaging of hydroxyglutarate mr spectroscopy imaging reveals effects of targeted treatment of mutant idh gliomas the effects of low to moderate prenatal alcohol exposure in early pregnancy on iq in year old children low moderate drinking in early pregnancy has no adverse effects on children aged five study suggests long term psychosocial outcomes after intraoperative awareness with recall no evidence of long term ptsd risk in patients with awareness during surgery using satellite based spatiotemporal resolved air temperature exposure to study the association between ambient air temperature and birth outcomes in massachusetts birth weight affected by warm temperatures during pregnancy radiographic detection of hip and pelvic fractures in the emergency department x rays often inaccurate in the diagnosis of hip and pelvic fractures using recorded audio feedback in cross cultural e education environments to enhance assessment practices in a higher education by using recorded audio feedback academics can reduce workload mentally and physically a neural basis for password based species recognition in an avian brood parasite neural basis for parasitic cowbird s secret password identified by researchers tarsier goggles a virtual reality tool for experiencing the optics of a dark adapted primate visual system new virtual reality tool allows you to see the world through the eyes of a tiny primate mirna profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome micrornas have diagnostic and prognostic potential in urinary bladder cancer tracking nutrient transfer at the human maternofetal interface from weeks to term research unlocks critical early nutrient supply for embryos evaluation of various feature sets and feature selection towards automatic recognition of bird species automated bird identification system based on bird calls and song burden of streptococcus pneumoniae and haemophilus influenzae type b disease in children in the era of conjugate vaccines global regional and national estimates for . million children s lives saved by hib and pneumococcal vaccines since ovulation leads women to perceive sexy cads as good dads why women choose bad boys ovulating women perceive sexy cads as good dads ancient genome wide analyses infer kinship structure in an early medieval alemannic graveyard dna of early medieval alemannic warriors and their entourage decoded individual prognosis at diagnosis in nonmetastatic prostate cancer development and external validation of the predict prostate multivariable model web tool aims to better inform and refine need for treatment in early prostate cancer increased colonic propionate reduces anticipatory reward responses in the human striatum to high energy foods cravings for high calorie foods may be switched off in the brain by new supplement the effect of elevated body mass index on ischemic heart disease risk causal estimates from a mendelian randomisation approach evidence that bmi has an independent and causal effect on heart disease risk pediatric loss of control eating syndrome association with attention deficit hyperactivity disorder and impulsivity children with adhd at risk for binge eating study shows can arginine permease deficiency extends yeast replicative lifespan via translational activation of stress response genes patterns of protein synthesis associated with increased longevity discovered association between physicians experiences with members of their social network and efforts to reduce breast cancer screening physicians experiences with family and friends impact breast cancer screening featured article induction of heme oxygenase with hemin improves pericardial adipocyte morphology and function in obese zucker rats by enhancing proteins of regeneration hemin improves adipocyte morphology function by enhancing proteins of regeneration mouse cloning using a drop of peripheral blood. cloning mice for the first time a donor mouse has been cloned using a drop of peripheral blood from its tail pecans acutely increase plasma postprandial antioxidant capacity and catechins and decrease ldl oxidation in humans antioxidants in pecans may contribute to heart health and disease prevention antioxidant activity of seed polyphenols in fifteen wild lathyrus species from south spain postwar food vecht is an important source of antioxidant activity an analyst by any other last name country favorability and market reaction to analyst forecasts stock market shows greater reaction to forecasts by analysts with favorable surnames herpes zoster at the vaccination site in immunized healthy children chicken pox vaccine linked with shingles at the vaccination site in some children novel oncogene induced metastatic prostate cancer cell lines define human prostate cancer progression signatures game changing diagnostic and prognostic prostate cancer genetic tests developed precise small molecule cleavage of an r cug repeat expansion in a myotonic dystrophy mouse model new therapy targets cause of adult onset muscular dystrophy lower extremity pain is associated with reduced function and psychosocial health in obese children foot knee and hip pain a problem in obese children association of state alcohol policies with alcohol related motor vehicle crash fatalities among us adults stronger alcohol policies help reduce alcohol related crash deaths in us a major role for rcan in atherosclerosis progression inhibiting a single protein could improve treatment of atherosclerosis prevalence rates of male and female sexual violence perpetrators in a national sample of adolescents nearly in young people report perpetrating sexual violence characterization of the h n highly pathogenic avian influenza virus derived from wild pikas in china new study finds wild pikas are natural mammalian hosts to h n avian influenza virus high altitude hyper arid soils of the central andes harbor mega diverse communities of actinobacteria dark matter discoveries could shine light on new treatments for diseases climate change mitigation and health effects of varied dietary patterns in real life settings throughout north america vegetarian diets produce fewer greenhouse gases and increase longevity say new studies cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin expression stress hormone is key factor in failure of immune system to prevent leukemia cigarette smoke extract induces prolonged endoplasmatic reticulum stress and autophagic cell death in human umbilical vein endothelial cells vessel damaging activation of the intracellular waste disposal mechanism found in smokers patterns of obesity and lymph fluid level during the first year of breast cancer treatment a prospective study nursing study examines obesity in relation to breast cancer related lymphedema the corona contracts in a black hole transient astronomers observe evolution of a black hole as it wolfs down stellar material impact of sleep restriction on neurobehavioral functioning of children with attention deficit hyperactivity disorder moderate sleep loss impairs vigilance and sustained attention in children with adhd identification of binocular vision dysfunction vertical heterophoria in traumatic brain injury patients and effects of individualized prismatic spectacle lenses in the treatment of postconcussive symptoms a retrospective analysis prismatic eyeglasses for headaches and dizziness caused by traumatic brain injury appears promising study finds estimated mortality on hiv treatment among active patients and patients lost to follow up in provinces of zambia findings from a multistage sampling based survey new model for uncovering true hiv mortality rates in zambia assessing africa wide pangolin exploitation by scaling local data pangolins at huge risk as study shows dramatic increases in hunting across central africa industrial grade bending insensitive transparent nanoforce touch sensor via enhanced percolation effect in a hierarchical nanocomposite film high performance flexible transparent force touch sensor for wearable devices mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass how cells react to injury from open heart surgery burn injury associated with home oxygen use in patients with chronic obstructive pulmonary disease oxygen therapy in copd patients associated with burn injury deep learning augmented rna seq analysis of transcript splicing new computational tool harnesses big data deep learning to reveal dark matter of the transcriptome declines in prevalence of adolescent substance use disorders and delinquent behaviors in the usa a unitary trend ? large declines seen in teen substance abuse delinquency large scale phylogenomic analysis reveals the complex evolutionary history of rabies virus in multiple carnivore hosts two major groups of rabies virus display distinct evolutionary trends pharmacological interventions for sleepiness and sleep disturbances caused by shift work shift workers evidence for sleep inducing and alertness drugs is weak time to reassess the cancer compendia for off label drug coverage in oncology researchers question process for reviewing coverage of off label cancer drug use glutamate spillover in c. elegans triggers repetitive behavior through presynaptic activation of mgl mglur research on repetitive worm behavior may have implications for understanding human disease awake clipping of cerebral aneurysms report of initial series surgeons study awake aneurysm surgery for better outcomes ambient air pollution impairs regulatory t cell function in asthma air pollution alters immune function worsens asthma symptoms study finds we made your bed why won t you lie in it ? food availability and disease may affect reproductive output of reintroduced frogs frog reproduction in created ponds may be affected by disease and food availability musserellusgen. nov. and five new species of fleas siphonaptera stivaliidae from murid rodents in sulawesi and west papua indonesia new genus and five new flea species discovered in indonesia prospective longitudinal analysis of hydroxyglutarate magnetic resonance spectroscopy identifies broad clinical utility for the management of patients with idh mutant glioma imaging with new biomarker tracks tumor progression response to treatment for common brain cancer global reconstruction of historical ocean heat storage and transport a century and half of reconstructed ocean warming offers clues for the future exploiting rrna operon copy number to investigate bacterial reproductive strategies revving the microbial engine horsepower versus fuel efficiency in bacterial genomes local adaptation to temperature conserves top down control in a grassland food web ecological adaptation likely to influence impacts of climate change finding water scarcity amid abundance using human natural system models to grasp water scarcity researchers probe links between human and natural systems infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation brain disease scenarios revised by step by step imaging of toxic aggregation mousensor a versatile genetic platform to create super sniffer mice for studying human odor coding super sniffer mice could detect land mines and decode human olfactory system management of hypertensive patients with multiple drug intolerances a single center experience of a novel treatment algorithm new approach to tackling uncontrolled high blood pressure shows significant results fuel treatment prescriptions alter spatial patterns of fire severity around the wildland urban interface during the wallow fire arizona usa there may be multiple paths to fuel reduction in the wildland urban interface the neotropical species of clistopyga hymenoptera ichneumonidae pimplinae. part ii the c. isayae species group with the description of seven new species new wasp species with a giant stinger discovered in amazonia psychological treatments a call for mental health science experts urge new discipline combining benefits of neuroscience psychology treatments preventative vaccines for zika virus outbreak preliminary evaluation preliminary zika vaccines prevent neurological disorders in newborn mice acetylcholine provoked coronary spasm at site of significant organic stenosis predicts poor prognosis in patients with coronary vasospastic angina spasm at site of atherosclerotic coronary artery narrowing increases risk of heart attack cancer cells co opt the neuronal redox sensing channel trpa to promote oxidative stress tolerance cancer cells co opt pain sensing wasabi receptor to survive oxidative stress meat authentication a new hplc ms ms based method for the fast and sensitive detection of horse and pork in highly processed food rooting out horse meat fraud in the wake of a recent food scandal sortase anchored proteins of streptococcus uberis play major roles in the pathogenesis of bovine mastitis in dairy cattle discovery could aid development of elusive bovine mastitis vaccine attentive scanning behavior drives one trial potentiation of hippocampal place fields neuroscientists brain activity may mark beginning of memories social transfer of pathogenic fungus promotes active immunisation in ant colonies how social contact with sick ants protects their nestmates disentangling the correlated evolution of monogamy and cooperation alternative explanations for the evolution of monogamy and sibling cooperation assessment of neuroinflammation in patients with idiopathic rapid eye movement sleep behaviour disorder a case control study restless sleep may be an early sign of parkinson s disease decreased plasma amyloid in the alzheimer s disease app a t variant carriers gene variant protecting against alzheimer s disease decreases plasma beta amyloid levels rescue of a mouse model of spinal muscular atrophy with respiratory distress type by aav ighmbp is dose dependent gene replacement therapy offers viable treatment option for fatal disease supersymmetric many body systems from partial symmetries integrability localization and scrambling can large stars anti aging research help future memory devices ? social position influencing the water perception gap between local leaders and constituents in a socio hydrological system involving the public in water policies is key to successful municipal water systems study finds posttraumatic stress disorder as a catalyst for the association between metabolic syndrome and reduced cortical thickness ptsd increases risk for metabolic syndrome reduced cortical thickness chronic conditions and utility based health related quality of life in adult childhood cancer survivors young adult survivors of childhood cancer report feeling middle aged exposure to violent media the effects of songs with violent lyrics on aggressive thoughts and feelings. violent music lyrics increase aggressive thoughts and feelings according to new study even humorous violent songs increase hostile feelings human immunodeficiency virus tat protein increases the number of inhibitory synapses between hippocampal neurons in culture hiv protein may impact neurocognitive impairment in infected patients the southward transport of sub mesoscale lenses of bass strait water in the centre of anti cyclonic mesoscale eddies from bass strait to the indian ocean tracking a current persistent natural acidification drives major distribution shifts in marine benthic ecosystems moderate increase of oceanic acidification leads to a dramatic shift in benthic habitats dense and dynamic polyethylene glycol shells cloak nanoparticles from uptake by liver endothelial cells for long blood circulation mushrooms and brushes help cancer fighting nanoparticles survive in the body evaluation of a validated methylation triage signature for human papillomavirus positive women in the hpv focal cervical cancer screening trial new epigenetic cervical cancer test has per cent detection rate infectious and noninfectious amyloids of the het s prion have different nmr spectra infectious and non infectious prions have clear differences in molecular structures steeper declines in forest photosynthesis than respiration explain age driven decreases in forest growth new look at old forests future growth of u.s. forests expected to decline a novel irfp incorporated in vivo murine atherosclerosis imaging system improved in vivo imaging of atherosclerotic plaque development reduced inferior frontal gyrus activation during response inhibition to emotional stimuli in youth at high risk of bipolar disorder brain imaging identifies bipolar disorder risk in adolescents cellulose ionic conductors with high differential thermal voltage for low grade heat harvesting wood based technology creates electricity from body heat evidence that independent gut to brain and brain to gut pathways operate in the irritable bowel syndrome and functional dyspepsia a year population based prospective study gastrointestinal disorders involve both brain to gut and gut to brain pathways affect of seizures during gestation on pregnancy outcomes in women with epilepsy seizures during pregnancy associated with risk of pre term and small babies synthetic lethal screens identify vulnerabilities in gpcr signalling and cytoskeletal organization in e cadherin deficient cells bright new hope for beating deadly hereditary stomach breast cancers associations of dietary intake and physical activity with sleep disordered breathing in the apnea positive pressure long term efficacy study apples severe obstructive sleep apnea linked to high fat diets and decreased physical activity in women effect of prenatal supplementation with vitamin d on asthma or recurrent wheezing in offspring by age years vitamin d supplementation during pregnancy may not reduce risk of asthma wheezing in offspring crowd vocal learning induces vocal dialects in bats playback of conspecifics shapes fundamental frequency usage by pups young bats learn bat dialects from their nestmates repeated translocation of a gene cassette drives sex chromosome turnover in strawberries jumping genes drive sex chromosome changes in strawberries insights into the abundance and diversity of abyssal megafauna in a polymetallic nodule region in the eastern clarion clipperton zone abundant and diverse ecosystem found in area targeted for deep sea mining the impact of anxiety disorders on assessment of myocardial ischemia and exercise stress test performance additional cardiac testing vital for patients with anxiety and depression rapid short pulse ultrasound delivers drugs uniformly across the murine blood brain barrier with negligible disruption new pulsing ultrasound technique improves drug delivery to brains of mice robotic arm rehabilitation in chronic stroke patients with aphasia may promote speech and language recovery but effect is not enhanced by supplementary tdcs robotic arm may help to rehabilitate chronic stroke victims subdecadal phytolith and charcoal records from lake malawi east africa imply minimal effects on human evolution from the ka toba supereruption no volcanic winter in east africa from ancient toba eruption proton magnetic resonance spectroscopy of the motor cortex in cervical myelopathy changes to the brain in patients with spinal cord compression identified the associations between objective numeracy and colorectal cancer screening knowledge attitudes and defensive processing in a deprived community sample people with low numeracy feel negative about taking part in bowel cancer screening parasite prevalence corresponds to host life history in a diverse assemblage of afrotropical birds and haemosporidian parasites study of african birds reveals hotbed of malaria parasite diversity living well with dementia a systematic review and correlational meta analysis of factors associated with quality of life well being and life satisfaction in people with dementia key factors to support quality of life in dementia tectonically triggered sediment and carbon export to the hadal zone earthquakes as a driver for the deep ocean carbon cycle genomic dissection of conserved transcriptional regulation in intestinal epithelial cells scientists map genomic atlas of your inner fish gut a new species of andinobates amphibia anura dendrobatidae from west central panama new poison dart frog species discovered in donoso panama effects of animal assisted therapy on social behaviour in patients with acquired brain injury a randomised controlled trial animal assisted therapy improves social behavior in patients with brain injuries diverse non genetic allele specific expression effects shape genetic architecture at the cellular level in the mammalian brain playing favorites brain cells prefer one parent s gene over the other s green fluorescence of cytaeis hydroids living in association with nassarius gastropods in the red sea new luminous creatures illuminate the mystery of the red sea treatment and outcomes of acute myocardial infarction complicated by shock after public reporting policy changes in new york excluding high risk cardiac patients from public reporting linked to improved outcomes earth s oldest bobbit worm gigantism in a devonian eunicidan polychaete million year old gigantic extinct monster worm discovered in canadian museum differentiation of human limbal derived induced pluripotent stem cells into limbal like epithelium science behind treating patients with corneal blindness advanced a network diffusion approach to inferring sample specific function reveals functional changes associated with breast cancer shifting protein networks in breast cancer may alter gene function when ethical leader behavior breaks bad how ethical leader behavior can turn abusive via ego depletion and moral licensing. when the boss s ethical behavior breaks bad a phase trial of pirfenidone in patients with idiopathic pulmonary fibrosis idiopathic pulmonary fibrosis promising drug therapies for fatal lung disease found cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain molecular causes of brain injury associated with gut condition uncovered presynaptically localized cyclic gmp dependent protein kinase is a key determinant of spinal synaptic potentiation and pain hypersensitivity new insights into the synaptic basis of chronic pain photon shell game in three resonator circuit quantum electrodynamics physicists challenge classical world with quantum mechanical implementation of shell game the human multipotent stromal cells attenuate lipopolysaccharide induced acute lung injury in mice via secretion of tumor necrosis factor induced protein stem cells from bone marrow may help treat acute lung injury recent increases in the u.s. maternal mortality rate disentangling trends from measurement issues us maternal mortality rates higher than reported study finds uncovering the behaviors of individual cells within a multicellular microvascular community surprising behavior of cells during blood vessel formation retinoblastoma and phosphate and tensin homolog tumor suppressors impact on ductal carcinoma in situ progression combined rb and pten loss identifies dcis primed for invasive breast cancer the influence of late quaternary climate change velocity on species endemism ancient climate change has left a strong imprint on modern ecosystems longitudinal associations between teen dating violence victimization and adverse health outcomes teen dating violence linked to long term harmful effects whole genome sequencing versus traditional genotyping for investigation of a mycobacterium tuberculosis outbreak a longitudinal molecular epidemiological study whole genome sequencing better at tracing tb outbreaks than standard test emerging cancer trends among young adults in the usa analysis of a population based cancer registry obesity related cancers rising in young adults in the us toll like receptors and dectin a c type lectin receptor trigger divergent functions in cns macrophages findings identify receptors modulating macrophage responses to spinal cord injury structural insights into the molecular organization of the s layer from clostridium difficile secrets of c. difficile s protective shell revealed paving the way for new superbug drugs and vaccines play project home consultation intervention program for young children with autism spectrum disorders parent coaching early intervention program benefits young children with autism the application of a decision theoretic model to estimate the public health impact of vaporized nicotine product initiation in the united states public health benefits of e cigarette use tend to outweigh the harms navigational memory functional magnetic resonance imaging a test for concussion in children finding a new test for children with concussions treatment of phantom limb pain plp based on augmented reality and gaming controlled by myoelectric pattern recognition a case study of a chronic plp patient phantom limb pain relieved when amputated arm is put back to work apple juice improved behavioral but not cognitive symptoms in moderate to late stage alzheimer s disease in an open label pilot study apple juice improves behavior but not cognition in alzheimer s patients study finds a per cent level determination of the nucleon axial coupling from quantum chromodynamics supercomputers provide new window into the life and death of a neutron the crossed leg sign indicates a favorable outcome after severe stroke crossing legs after severe stroke may be a good sign of recovery utilizing colored dissolved organic matter to derive dissolved black carbon export by arctic rivers climate change likely to increase black carbon input to the arctic ocean women s visibility in academic seminars women ask fewer questions than men women much less likely to ask questions in academic seminars than men spray toxicity and risk potential of commonly used formulations of row crop pesticides to adult honey bees hymenoptera apidae study finds glyphosate acetamiprid to have relatively low toxicity for honey bees pth promotes allograft integration in a calvarial bone defect hormone therapy could enhance therapeutic effect of head facial bone grafts widespread shifts in the coastal biota of northern california during the marine heatwaves unprecedented number of warm water species moved northward during marine heatwave adhesion and immunomodulatory effects of bifidobacterium lactis hn on intestinal epithelial cells int adhesion and immunomodulatory properties of a probiotic strain b. lactis hn prostaglandin e alters wnt dependent migration and proliferation in neuroectodermal stem cells implications for autism spectrum disorders lipid levels during prenatal brain development impact autism study shows the genetics of blood pressure regulation and its target organs from association studies in individuals new studies double number of known sites in genome linked to high blood pressure recyclable amine functionalized magnetic nanoparticles for efficient demulsification of crude oil in water emulsions particles pull last drops of oil from well water the genome of the leaf cutting ant acromyrmex echinatior suggests key adaptations to advanced social life and fungus farming fungus farming ant genome reveals insight into adaptation of social behavior does long term use of psychiatric drugs cause more harm than good ? debate is the long term use of psychiatric drugs harmful ? metallic nanoparticle contacts for high yield ambient stable molecular monolayer devices electrical contact to molecules in semiconductor structures established for the first time shifting signals to help health using identity signaling to reduce risky health behaviors part of the in group ? a surprising new strategy helps reduce unhealthy behaviors direct analysis of incorporation of an anticancer drug into dna at single molecule resolution tiny dna reader to advance development of anticancer drugs trends in underlying causes of death in people with hiv from to d a d a multicohort collaboration causes of death shifting in people with hiv ancient dna of the extinct jamaican monkey xenothrix reveals extreme insular change within a morphologically conservative radiation primates of the caribbean ancient dna reveals history of mystery monkey electronegativity seen as the ground state average valence electron binding energy new scale for electronegativity rewrites the chemistry textbook giant kelp macrocystis pyrifera increases faunal diversity through physical engineering marine ecologists study the effects of giant kelp on groups of organisms in the underwater forest ecosystem meta analysis of modifiable risk factors for alzheimer s disease nine risk factors may contribute to two thirds of alzheimer s cases worldwide the fields medal should return to its roots the fields medal fallacy why this math prize should return to its roots fbh affects warm temperature responses in the arabidopsis circadian clock genetic switch regulates a plant s internal clock based on temperature protein altering and regulatory genetic variants near gata implicated in bicuspid aortic valve two genetic variants in bicuspid aortic valve development occurrence of neonicotinoid insecticides in finished drinking water and fate during drinking water treatment neonicotinoids detected in drinking water in agricultural area scientists views and positions on global warming and climate change a content analysis of congressional testimonies hurdles to us climate change action are in economics and politics not divided science pharmacological inhibition of the dna damage checkpoint prevents radiation induced oocyte death drug may curb female infertility from cancer treatments anticholinergic vs long acting agonist in combination with inhaled corticosteroids in black adults with asthma study compares combination treatments for black adults with asthma high throughput platform for the discovery of elicitors of silent bacterial gene clusters unlocking potential of bacterial gene clusters to discover new antibiotics a molecular assembly phase transition and kinetic proofreading modulate ras activation by sos breakthrough study of cell signaling holds promise for immune research and beyond human intracellular isg prevents interferon over amplification and auto inflammation single gene links susceptibility to rare infections with predisposition to autoimmune disease food induced anaphylaxis to a known food allergen in children often occurs despite adult supervision food induced anaphylaxis common among children despite adult supervision major intensification of atlantic overturning circulation at the onset of paleogene greenhouse warmth how the atlantic ocean became part of the global circulation at a climatic tipping point methyl cpg binding protein regulates microglia and macrophage gene expression in response to inflammatory stimuli new research implicates immune system in rett syndrome metacognitive scaffolding boosts cognitive and neural benefits following executive attention training in children attention training improves intelligence and functioning of children s brain the impact of the demographic transition on dengue in thailand insights from a statistical analysis and mathematical modeling shift in age distribution of dengue fever in thailand explained pedaling rate is an important determinant of human oxygen uptake during exercise on the cycle ergometer pedaling like a tour de france winner is a losing strategy for most of us millennial scale isotope records from a wide ranging predator show evidence of recent human impact to oceanic food webs seabird bones reveal changes in open ocean food chain hiv tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome implications for hiv associated neurocognitive disorders key mechanisms underlying hiv associated cognitive disorders identified consensus statement chromosomal microarray is a first tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies consortium recommends microarray testing as new standard for pediatric genetic diagnosis ventro striatal reductions underpin symptoms of hyperactivity and impulsivity in attention deficit hyperactivity disorder scientists discover alterations in brain s reward system related to attention deficit hyperactivity disorder structural principles in robo activation and auto inhibition crystal clear view of a key neuronal receptor opens door for new targeted drugs association of growth differentiation factor putative anti ageing factor with cardiovascular outcomes and overall mortality in humans analysis of the heart and soul and hunt cohorts fountain of youth protein points to possible human health benefit sulfide generation by dominant halanaerobium microorganisms in hydraulically fractured shales sulfide producing bacteria dominate hydraulically fractured oil gas wells notch signaling in fizz induction of myofibroblast differentiation notch contributes to scar tissue in the lungs the hox gene abd b controls stem cell niche function in the drosophila testis developmental gene influences sperm formation fruit fly model demonstrates long delays in banning trade in threatened species delays in banning wildlife trade put hundreds of species at risk diabetes is associated with impairment of uterine contractility and high caesarean section rate poorly contracting uterus in diabetic women increases risk of caesarean birth researchers find olig dependent reciprocal shift in pdgf and egf receptor signaling regulates tumor phenotype and mitotic growth in malignant glioma experimental therapy halts treatment resistant brain tumors in mouse model vishniacozyma ellesmerensis sp. nov. a psychrophilic yeast isolated from a retreating glacier in the canadian high arctic scientists identify two new species of fungi in retreating arctic glacier fine mapping identifies two additional breast cancer susceptibility loci at q.. two new genetic variants linked to breast cancer a unique oct interface is crucial for reprogramming to pluripotency new light shed on reprogramming mature cells to pluripotency to divide and differentiate into specialized cell types floodplains as an achilles heel of amazonian forest resilience flammable floodplains are weak spot of amazon forest model driven engineering of rna devices to quantitatively program gene expression computer assisted design cad for rna researchers develop cad type tools for engineering rna control systems novel methylated biomarkers and a robust assay to detect circulating tumor dna in metastatic breast cancer experimental blood test spots recurrent breast cancers monitors response to treatment metabolic reprogramming in triple negative breast cancer through myc suppression of txnip molecular signature for outcomes of triple negative breast cancer proposed percutaneous aortic valve prosthesis made of cryogel new heart valve aimed at high risk patients contributions of local farming to urban sustainability in the northeast united states urban agriculture only provides small environmental benefits in northeastern us pest management strategies for bed bugs hemiptera cimicidae in multiunit housing a literature review on field studies bed bugs proactive pest management critical in multi unit housing quantitative measurement of melanoma spread in sentinel lymph nodes and survival the number of tumor cells spread to sentinel lymph nodes affects melanoma prognosis daily opioid use fluctuates as a function of pain catastrophizing and affect in patients with sickle cell disease an electronic daily diary analysis negative emotions linked to higher rates of opioid use in sickle cell disease junk food and heart disease the missing tooth junk food poor oral health increase risk of premature heart disease epidemiology of injuries in major league baseball catchers bats and balls not base runners cause worst injuries to major league catchers the silicon cycle impacted by past ice sheets ice sheets of the last ice age seeded the ocean with essential nutrient silica assessment of relative active tectonics southwest border of the sierra nevada southern spain new geomorphological index created for studying active tectonics of mountains frontal lesions predict response to prism adaptation treatment in spatial neglect a randomised controlled study stroke researchers confirm role of frontal lesions in response to prism treatment sacred values ? the effect of information on attitudes toward payments for human organs consideration of costs can reduce moral objections to human organ sales and other repugnant transactions says researcher family history of colorectal cancer it is time to rethink screening recommendations researcher calls for changes to colorectal cancer screening guidelines a parts list for fungal cellulosomes revealed by comparative genomics guts to glory ? newly discovered enzyme complexes in herbivore digestive tracts show promise for sustainable fuels medicines efficacy and safety of celgosivir in patients with dengue fever celaden a phase b randomised double blind placebo controlled proof of concept trial a step closer to finding treatment for dengue fever common snps in hmgcr in micronesians and whites associated with ldl cholesterol levels affect alternative splicing of exon single letter in human genome points to risk for high cholesterol morphine immunomodulation prolongs inflammatory and postoperative pain while the novel analgesic zh accelerates recovery and protects against latent sensitization new opioid speeds up recovery without increasing pain sensitivity or risk of chronic pain psychotropic medication use in children and adolescents with down syndrome study examines psychotropic medication use in children teens with down syndrome moving kinetics of nanocars with hydrophobic wheels on solid surfaces at ambient conditions nanocars taken for a rough ride single molecule cars tested in open air eyeless mexican cavefish save energy by eliminating the circadian rhythm in metabolism eyeless mexican cavefish eliminate circadian rhythm to save energy poor owner knowledge of feline reproduction contributes to the high proportion of accidental litters born to uk pet cats poor owner knowledge of cat sex life linked to unplanned kittens every year a novel platform for engineering blood brain barrier crossing bispecific biologics new molecule sneaks medicines across blood brain barrier defective hiv proviruses produce novel protein coding rna species in hiv infected patients on combination antiretroviral therapy defective hiv dna can encode hiv related proteins tnf signaling exposes latent estrogen receptor binding sites to alter the breast cancer cell transcriptome molecular genetic mechanisms driving breast cancer progression study reveals assuring the involvement of children in the evaluation of new tuberculosis treatment regimens lack of tuberculosis trials in children unacceptable experts argue mitochondrial dysfunction induces senescence with a distinct secretory phenotype signaling from dysfunctional mitochondria induces cellular senescence with a distinct secretory phenotype phantom pain is associated with preserved structure and function in the former hand area amputee phantom pain linked to brain retaining picture of missing limb a single phosphorodiamidate morpholino oligomer targeting vp protects rhesus monkeys against lethal ebola virus infection drug targeting ebola virus protein vp shows promise in monkeys global burden of disease due to smokeless tobacco consumption in adults analysis of data from countries something to chew on millions of lives blighted by smokeless tobacco differential effects of simvastatin and pravastatin on expression of alzheimer s disease related genes in human astrocytes and neuronal cells statins show dramatic drug and cell dependent effects in the brain sphingosine phosphate links persistent stat activation chronic intestinal inflammation and development of colitis associated cancer multiple sclerosis drug may one day treat colorectal cancer cost offset associated with early start denver model for children with autism high quality early intervention for children with autism quickly results in costs savings high resolution spatiotemporal transcriptome mapping of tomato fruit development and ripening new tomato expression atlas dives deep into the fruit s flesh ultra fast escape maneuver of an octopus inspired robot octopus robot makes waves with ultra fast propulsion navigating a d virtual world using direct brain stimulation no peeking humans play computer game using only direct brain stimulation an year follow up on the effect of subthalamic nucleus deep brain stimulation on pain in parkinson disease long term effect of deep brain stimulation on pain in patients with parkinson s disease parainfluenza virus expressing the g protein of rabies virus protected mice after rabies virus infection beating the clock researchers develop new treatment for rabies evaluation of an early risk screener for ptsd in preschool children after accidental injury. identifying trauma risk in small children early after an accident recall of physical activity advice was associated with higher levels of physical activity in colorectal cancer patients two thirds of bowel cancer patients aren t advised to exercise despite health benefits vitamin d deficiency and reduced lung function in connective tissue associated interstitial lung diseases vitamin d deficiencies may impact onset of autoimmune lung disease the impact of maternal smoking during pregnancy on early child neurodevelopment effects of prenatal smoking on infant neurodevelopment may be worse than feared psychosocial adjustment and perceived risk among adolescent girls from families with brca or breast cancer history teen girls with a family history of breast cancer do not experience increased depression or anxiety risk stratification after paracetamol overdose using mechanistic biomarkers results from two prospective cohort studies blood test spots paracetamol overdose patients at risk of liver damage corals in healthy populations produce more larvae per unit cover healthy coral populations produce a surprising number of offspring giant fossil tortoise and freshwater chelid turtle remains from the middle miocene quebrada honda bolivia evidence for lower paleoelevations for the southern altiplano reptile fossils offer clues about elevation history of andes mountains genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy patient s own cells may hold therapeutic promise after reprogramming gene correction inability to suppress the stress induced activation of the hpa axis during the peripartum period engenders deficits in postpartum behaviors in mice neuroscientists shed light on causes of postpartum depression using new research model photosynthetic innovation broadens the niche within a single species scientists move a step closer to understanding species distributions in the face of climate change utilizing sensory prediction errors for movement intention decoding a new methodology reading the motor intention from brain activity within ms hospital variation in time to epinephrine for non shockable in hospital cardiac arrest adrenaline rush delaying epinephrine shots after cardiac arrest cuts survival rates hepatoma derived growth factor predicts disease severity and survival in pulmonary artery hypertension blood test shows promise in gauging severity of pulmonary arterial hypertension therapeutic effects of intra arterial delivery of bone marrow stromal cells in traumatic brain injury of rats in vivo cell tracking study by near infrared fluorescence imaging encouraging results with stem cell transplant for brain injury a complex hydride lithium superionic conductor for high energy density all solid state lithium metal batteries highest energy density all solid state batteries now possible validity of the diagnostic criteria for chronic cerebrospinal venous insufficiency and association with multiple scleros no apparent link between chronic cerebrospinal venous insufficiency multiple sclerosis smallest microhouse in the world assembled on the facet of an optical fiber by origami and welded in the robotex nanofactory robotic assembly of the world s smallest house even a mite doesn t fit through the door ! a living biobank of breast cancer organoids captures disease heterogeneity using d cell cultures to fight anti cancer therapy resistance moment tensor inversion of seismic events associated with the sinkhole at napoleonville salt dome gas charged fluids creating seismicity associated with a louisiana sinkhole mechanical loading disrupts osteocyte plasma membranes which initiates mechanosensation events in bone tears in tiny bone cells called osteocytes appear an important step to better bones effect of deutetrabenazine on chorea among patients with huntington disease a randomized clinical trial drug helps control involuntary sudden movements of huntington disease critical role of the ubl domain in stimulating the e ubiquitin ligase activity of uhrf toward chromatin a new piece to the puzzle sheds light on how uhrf regulates gene activity island life shapes the physiology and life history of eastern bluebirds sialia sialis bluebirds struggle to find happiness on island paradise origins of the mechanochemical coupling of peptide bond formation to protein synthesis mechanical force controls the speed of protein synthesis mammal decline linked to invasive burmese python shifts host use of vector mosquito towards reservoir hosts of a zoonotic disease burmese python s hungry escapades may have consequences for human health the animal in you animalistic descriptions of a violent crime increase punishment of perpetrator animalistic descriptions of violent crimes increase punishment of perpetrators accuracy of rapid and point of care screening tests for hepatitis ca systematic review and meta analysis new rapid and point of care hepatitis c tests could be global game changers activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy major blood vessel constrictor contributes to vision loss in preemies modeling the acmg amp variant classification guidelines as a bayesian classification framework a centuries old math equation used to solve a modern day genetics challenge gradients in primary production predict trophic strategies of mixotrophic corals across spatial scales estimating the feeding habits of corals may offer new insights on resilient reefs value of mri after recent diagnostic or surgical intervention in children with suspected osteomyelitis mri can eliminate unnecessary surgery for children with suspected musculosketal infections the effects of physical activity and fatigue on cognitive performance in breast cancer survivors physical activity could combat fatigue cognitive decline in cancer survivors sex based disparities in incidence treatment and outcomes of cardiac arrest in the united states gender gap found in cardiac arrest care outcomes a meaner more callous digital world for youth ? the relationship between violent digital games motivation bullying and civic behavior among children. are violent video games associated with more civic behaviors among youth ? smithornis broadbills produce loud wing song by aeroelastic flutter of medial primary wing feathers researchers document how broadbills make loud wing song superior inhibitory control and resistance to mental fatigue in professional road cyclists elite cyclists are more resilient to mental fatigue exposure to violence across the social ecosystem and the development of aggression a test of ecological theory in the israeli palestinian conflict chain of violence study shows impact on palestinian and israeli children targeting er stress induced autophagy overcomes braf inhibitor resistance in melanoma blocking autophagy with malaria drug may help overcome resistance to braf drugs in melanoma favorable preliminary outcomes for men with low and intermediate risk prostate cancer treated with gy single fraction high dose rate brachytherapy study finds single escalated dose of brachytherapy radiation may be a safe and effective treatment for localized prostate cancer causal link between the cortico rubral pathway and functional recovery through forced impaired limb use in rats with stroke link between intensive post stroke rehabilitation and recovery demonstrated in rats insect stereopsis demonstrated using a d insect cinema bug eyes tiny d glasses confirm insect d vision imaging of glial cell activation and white matter integrity in brains of active and recently retired national football league players evidence of brain injury found in young nfl players are species genetically more sensitive to habitat fragmentation on the periphery of their range compared to the core ? a case study on the sand lizard lacerta agilis life on the edge of a habitat is dangerous historical temperature variability affects coral response to heat stress some corals like it hot heat stress may help coral reefs survive climate change flow topologies in primary atomization of liquid jets a direct numerical simulation analysis supercomputing propels jet atomization research for industrial processes phase iii trial of low level laser therapy to prevent oral mucositis in head and neck cancer patients treated with concurrent chemoradiation shining the soothing light to reduce canker sores in patients with head and neck squamous cell carcinoma prevalence of severe congenital heart disease after folic acid fortification of grain products time trend analysis in quebec canada folic acid effecive in preventing congenital heart defects canadian research shows global circulation patterns of seasonal influenza viruses vary with antigenic drift virus evolution and human behavior shape global patterns of flu movement biomechanical regulation of blood vessel growth during tissue vascularization model for new generation of blood vessels challenged rna seq of gliomas revealed a novel recurrent ptprz met fusion transcript in secondary glioblastomas new target for personalized brain cancer treatment ptprz met fusion protein associations of diet and lifestyle with headache in high school students alcohol use and smoking are associated with headaches in high schoolers geochemical evidence for expansion of marine euxinia during an early silurian llandovery wenlock boundary mass extinction in ancient oceans that resembled our own oxygen loss triggered mass extinction wave packet spreading with disordered nonlinear discrete time quantum walks simulations of quantum transport universal spreading laws confirmed sex differences in neural and behavioral signatures of cooperation revealed by fnirs hyperscanning differences in male female brain activity found when it comes to cooperation addressing on abrupt global warming warming trend slowdown and related features in recent decades role of natural factors on recent climate change underestimated research shows using genetic profiles of african forest elephants to infer population structure movements and habitat use in a conservation and development landscape in gabon study of african forest elephants helps guide research efforts in us fatal and nonfatal overdose among pregnant and postpartum women in massachusetts study analyzes opioid overdose risk during and after pregnancy among massachusetts women prognostic factors and time related changes influence results of colorectal liver metastases surgical treatment a single center analysis advances in liver surgery enable the prospect of curative treatment for more patients linear and nonlinear wave propagation in booming sand dunes physics of booming and burping sand dunes revealed spectrum of acute clinical characteristics of diagnosed concussions in college athletes wearing instrumented helmets concussion spectrum in college athletes wearing helmets not so simple say researchers genome scale engineering of saccharomyces cerevisiae with single nucleotide precision new crispr technology knocks out yeast genes with single point precision vaginal challenge with an siv based dual reporter system reveals that infection can occur throughout the upper and lower female reproductive tract entire female reproductive tract susceptible to hiv infection in macaque model humoral responses after influenza vaccination are severely reduced in patients with rheumatoid arthritis treated with rituximab efficacy of flu vaccine drastically reduced for ra patients treated with rituximab effect of smoke free legislation on perinatal and child health a systematic review and meta analysis public smoking bans linked with rapid fall in preterm births child hospital visits for asthma nanoparticle directed sub cellular localization of doxorubicin and the sensitization breast cancer cells by circumventing gst mediated drug resistance nanoparticles can overcome drug resistance in breast cancer cells the role of literacy skills in adolescents mathematics word problem performance controlling for visuo spatial ability and mathematics anxiety role of literacy skills in adolescents mathematics word problem performance patient specific vaccines derived from autologous tumor cell lines as active specific immunotherapy results of exploratory phase i ii trials in patients with metastatic melanoma patient specific vaccines for metastatic melanoma may induce durable complete regression study shows mutations in components of antiviral or microbial defense as a basis for breast cancer mutations of immune system found in breast cancers recreational angling intensity correlates with alteration of vulnerability to fishing in a carnivorous coastal fish species clever fish around the coast of mallorca island avoid fishing lines normal breast tissue dna methylation differences at regulatory elements are associated with the cancer risk factor age molecular changes with age in normal breast tissue are linked to cancer related changes doxylamine pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial prespecified analyses and reanalysis new report calls into question effectiveness of pregnancy anti nausea drug functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript study sheds light into the nature of embryonic stem cells hierarchical patterns of three dimensional block copolymer films formed by electrohydrodynamic jet printing and self assembly invention jet prints nanostructures with self assembling material chd is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression new insights into neuroblastoma tumor suppressor may provide clues for improved treatment cost effectiveness of lower extremity compression ultrasound in emergency department patients with a high risk of hemodynamically stable pulmonary embolism selective strategy recommended for ct scans in emergency departments geochemical evidence for m lange melting in global arcs volcanic arcs form by deep melting of rock mixtures induced telomere damage to treat telomerase expressing therapy resistant pediatric brain tumors possible novel method for stopping untreatable pediatric brain cancers risk of herpes zoster in patients with rheumatoid arthritis treated with anti u tnf alpha agents type of rheumatoid arthritis medication may be associated with increased risk for shingles influenza a virus induces autophagosomal targeting of ribosomal proteins building a flu factory from host cell components gender differences in alcohol treatment an analysis of outcome from the combine study men and women respond equally to naltrexone as treatment for alcohol dependence development of purple endosperm rice by engineering anthocyanin biosynthesis in the endosperm with a high efficiency transgene stacking system genetic engineering tool generates antioxidant rich purple rice methionine deprivation induces a targetable vulnerability in triple negative breast cancer cells by enhancing trail receptor expression dietary intervention primes triple negative breast cancer for targeted therapy isolation and characterization of equine endometrial mesenchymal stromal cells new insights could lead to lasting improvement of stem cell therapy in horses growth and proliferation of human embryonic stem cells on fully synthetic scaffolds based on carbon nanotubes new stem cell research removes reliance on human and animal cells cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer cartilage protein may contribute to the development of breast cancer molecular dissection of fus points at synergistic effect of low complexity domains in toxicity molecular culprits of protein aggregation in als and ftld mutation tracking in circulating tumor dna predicts relapse in early breast cancer new mutation tracking blood test could predict breast cancer relapse months in advance emended description and resurrection of kadsura matsudae schisandraceae mistaken identity of east asian vine species resolved after years simultaneous purifying selection on the ancestral mc r allele and positive selection on the melanoma risk allele v l in south europeans evolutionary medicine of skin cancer risk among europeans monolignol ferulate conjugates are naturally incorporated into plant lignins with designer lignin biofuels researchers reproduced evolutionary path a targeted analysis identifies a high frequency of brca and brca mutation carriers in women with ovarian cancer from a founder population ovarian cancer genetic testing should be accessible to all women with the disease targeting bmi cancer stem cells overcomes chemoresistance and inhibits metastases in squamous cell carcinoma targeting cancer stem cells improves treatment effectiveness prevents metastasis adverse childhood experiences are associated with spontaneous preterm birth a case control study researchers discover surprising link between chronic stress preterm birth increased risk of high grade prostate cancer among infertile men infertility increases a man s risk of prostate cancer effects of early onset voluntary exercise on adult physical activity and associated phenotypes in mice exercising early in life yields rewards in adult years molecular engineering of rantes peptide mimetics with potent anti hiv activity engineered protein fragment blocks the aids virus from entering cells visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention vipviza a pragmatic open label randomised controlled trial personalized ultrasound scan showing atherosclerosis helps reduce cardiovascular risk intuitive control of a powered prosthetic leg during ambulation control system shows potential for improving function of powered prosthetic leg clinical evidence of disease anticipation in families segregating a c orf repeat expansion children of patients with c orf mutations are at a greater risk of frontotemporal dementia or als at a younger age whose job will be taken over by a computer ? the role of personality in predicting job computerizability over the lifespan personality factors are best defense against losing your job to a robot global disease outbreaks associated with the el ni o event el ni o triggered disease outbreaks across globe the use of music and singing to help manage anxiety in older adults music as therapeutic intervention can relieve anxiety depression in older people marine diatom proteorhodopsins and their potential role in coping with low iron availability protein identified in certain microalgae changes conversation about climate change us emergency department visits for adverse drug events from antibiotics in children antibiotic side effects in kids lead to nearly er visits in the us each year e cigarette or drug delivery device ? regulating novel nicotine products e cigarette or drug delivery device ? questions about safety usage and future implications of new nicotine delivery products integration of gene expression and brain wide connectivity reveals the multiscale organization of mouse hippocampal networks scientists create new map of brain region linked to alzheimer s disease er stress drives lipogenesis and steatohepatitis via caspase activation of s p caspase enzyme inhibitor shows promise for ameliorating fatty liver disease reproductive performance of alternative male phenotypes of growth hormone transgenic atlantic salmon salmo salar genetically modified atlantic salmon mating study reveals danger of escape to wild gene pool white matter maturation reshapes structural connectivity in the late developing human brain brain s journey from early internet to modern day fiber optics computer program shows how brain s complex fiber tracks mature selective role of the catalytic pi k subunit p in impaired higher order cognition in fragile x syndrome fragile x syndrome building a case for an alternative treatment strategy the genetic prehistory of the baltic sea region northern european population history revealed by ancient human genomes hybridization patterns in two contact zones of grass snakes reveal a new central european snake species a new snake in europe the barred grass snake is described as a separate species insurance status and disparities in disease presentation treatment and outcomes for men with germ cell tumors insurance status impacts survival in men with testicular cancer obesity related metabolic dysfunction in dogs a comparison with human metabolic syndrome obese dogs at risk of health condition experienced by humans characterizing potentially induced earthquake rate changes in the brawley seismic zone southern california some signs of induced seismicity spotted in salton trough s geothermal production fields life course pathways to racial disparities in cognitive impairment among older americans study investigates why blacks have higher risk of cognitive impairment direct dna analysis with paper based ion concentration polarization paper based test could diagnose hepatitis b and assess male fertility at low cost optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer implications for screening early lung cancer detection optical technology shows potential for prescreening patients at high risk childhood trauma and risk for chronic fatigue syndrome association with neuroendocrine dysfunction childhood trauma and chronic fatigue syndrome risk biologically linked tbcrc phase ii trial correlating standardized uptake value with pathologic complete response to pertuzumab and trastuzumab in breast cancer pet scans show biomarkers could spare some breast cancer patients from chemotherapy are hiv epidemics among men who have sex with men emerging in the middle east and north africa ? a systematic review and data synthesis first large study to find hiv epidemic among gays in the middle east psychosocial adjustment in school age girls with a family history of breast cancer family risk of breast cancer does not affect psychosocial adjustment among pre teen girls tunable resonator upconverted emission true color printing and applications in optical security optical security tunable resonator upconverted emission color printing progressive increase in mtdna a g heteroplasmy causes abrupt transcriptional reprogramming steadily rising increases in mitochondrial dna mutations cause abrupt shifts in disease maternally provided lsd kdm a enables the maternal to zygotic transition and prevents defects that manifest postnatally disruptions to embryonic reprogramming alter adult mouse behavior dabconium an efficient and high voltage stable singlet oxygen quencher for metal o cells battery research new breakthroughs in research on super batteries recapitulating cross species transmission of sivcpz to humans using humanized blt mice forms of hiv can cross from chimps to humans study confirms adult pancreas side population cells expand after cell injury and are a source of insulin secreting cells pancreas stem cell discovery may lead to new diabetes treatments the symptom perception hypothesis revised depression and anxiety play different roles in concurrent and retrospective physical symptom reporting. depression and anxiety differentially influence physical symptom reporting a vlp vaccine for epidemic chikungunya virus protects non human primates against infection virus like particle vaccine protects monkeys from chikungunya virus inequality and health among foreign born latinos in rural borderland communities study documents poor mental and physical health in rural borderland community members estimated drinking water fluoride exposure and risk of hip fracture a cohort study drinking fluoridated water gives no additional risks for hip fractures therapeutic effects of glatiramer acetate and grafted cd monocytes in a mouse model of alzheimer s disease enriched blood cells preserve cognition in mice with features of alzheimer s disease assessment of capture and amplicon based approaches for the development of a targeted next generation sequencing pipeline to personalize lymphoma management harnessing the power of genomic sequencing augments diagnosis and treatment of lymphoid cancer a single injection of crystallizable fragment domain modified antibodies elicits durable protection from shiv infection genetically altered broadly neutralizing antibodies protect monkeys from hiv like virus the bifidobacterium dentium bd genome sequence reflects its genetic adaptation to the human oral cavity genetic study reveals the origins of cavity causing bacteria characterization of the olfactory receptor or h in human urinary bladder cancer olfactory receptor as therapeutic target in bladder cancer enterococci concentrations in a coastal ecosystem are a function of fecal source input environmental conditions and environmental sources better methods improve measurements of recreational water quality hiv therapy with monoclonal antibody bnc elicits host immune responses against hiv antibody therapy opens door to potential new treatment for hiv the time trial a fully embedded cluster randomized pragmatic trial of hemodialysis session duration investigators incorporate randomized trial within dialysis care delivery multiplexed rnai therapy against brain tumor initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression nanomedicine opens door to precision medicine for brain tumors regional rainfall decline in australia attributed to anthropogenic greenhouse gases and ozone levels australia drying caused by greenhouse gases study shows immunization responses in rheumatoid arthritis patients treated with rituximab results from a controlled clinical trial immune responses to tetanus vaccine unchanged for ra patients on rituximab increased function of pronociceptive trpv at the level of the joint in a rat model of osteoarthritis pain progress in osteoarthritis pain relief signaled by new research clinic versus over the counter access to oral contraception choices women make along the us mexico border convenience drives us women to buy over the counter contraception in mexico study finds impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity common childhood asthma not rooted in allergens inflammation a geological perspective on sea level rise and its impacts along the u.s. mid atlantic coast new jersey shore likely faces unprecedented flooding by mid century mkln splicing defect in dogs with lethal acrodermatitis genetic cause of deadly skin condition afflicting bull terriers discovered ckd prevalence varies across the european general population chronic kidney disease prevalence varies greatly across europe a maternal junk food diet reduces sensitivity to the opioid antagonist naloxone in offspring postweaning eating junk food while pregnant may make your child a junk food addict comparison of the chloride channel activator lubiprostone and the oral laxative polyethylene glycol on mucosal barrier repair in ischemic injured porcine intestine what s the influence of laxative agents on mucosal barrier repair ? high levels of mesophotic reef fish endemism in the northwestern hawaiian islands fish species unique to hawaii dominate deep coral reefs in northwestern hawaiian islands monoamine oxidase a genotype is associated with gang membership and weapon use warrior gene linked to gang membership weapon use falling bladder cancer incidence from to is not producing universal mortality improvements bladder cancer the only top cancer where survival rates are falling in uk the nih toolbox cognitive battery for intellectual disabilities three preliminary studies and future directions cognitive function tests reliable for people with intellectual disabilities research shows results of a preclinical randomized controlled multicenter trial prct anti cd d treatment for acute brain ischemia stroke therapy put to the test in preclinical randomized controlled trial influenza vaccination rates and beliefs about vaccination among nursing home employees low influenza vaccination rates among nursing home employees put residents at risk study finds decreased circulating levels of spexin in obese children low hormone levels linked to obesity in teens can male vaccination reduce the burden of human papillomavirus related disease in the united states ? should young men be vaccinated against human papilloma virus ? shrinking wings for ultrasonic pitch production hyperintense ultra short wavelength calls in a new genus of neotropical katydids orthoptera tettigoniidae newly discovered insect supersonus hits animal kingdom s highest pitch love call acupuncture instead of codeine for tonsillectomy pain in children study finds acupuncture effective in treating pain after tonsillectomy surgery symptom disease pair analysis of diagnostic error spade a conceptual framework and methodological approach for unearthing misdiagnosis related harms using big data a method to measure diagnostic errors could be key to preventing disability and death from misdiagnosis an x ray chimney extending hundreds of parsecs above and below the galactic centre giant x ray chimneys are exhaust vents for vast energies produced at milky way s center daily stress processes as contributors to and targets for promoting cognitive health in later life response to daily stressors could affect brain health in older adults math at home adds up to achievement in school math story time at home bolsters achievement in school beaked whales respond to simulated and actual navy sonar naval sonar exercises linked to whale strandings according to new report effects of granulocyte colony stimulating factor on chromosome aneuploidy and replication asynchrony in healthy peripheral blood stem cell donors stem cell mobilization therapy safe for bone marrow donors study suggests water supply risk on the colorado river can management mitigate ? future of western u.s. water supply threatened by climate change antibiotic induced alterations of the gut microbiota alter secondary bile acid production and allow for clostridium difficile spore germination and outgrowth in the large intestine antibiotics pave way for c. diff infections by killing bile acid altering bacteria kaposi s sarcoma associated herpesvirus orf protein interacts with pym to enhance translation of viral intronless mrnas potential new drug target to combat kaposi s sarcoma regulation and rate enhancement during transcription coupled dna repair details of microbe s extraordinary maintenance and repair system revealed efficacy of fecal microbiota transplantation for clostridium difficile infection in children fecal microbiota transplant found safe and effective in children with c. difficile the fate of the historic fortifications at alcatraz island based on terrestrial laser scans and ground penetrating radar interpretations from the recreation yard high tech laser scans uncover hidden military traverse at alcatraz island the presenilin loop region is essential for glycogen synthase kinase beta mediated functions on motor proteins during axonal transport mystery deepens over the cause of alzheimer s cell based systems biology analysis of human as adjuvanted h n avian influenza vaccine responses a phase i randomized controlled trial team uncovers cellular responses to bird flu vaccine brain changes in overweight obese and normal weight adults with type diabetes mellitus overweight obese people with diabetes at increased risk of brain abnormalities outcomes of children receiving group early start denver model in an inclusive versus autism specific setting a pilot randomized controlled trial children with autism thrive in mainstream pre schools astrocyte contributions to flow pressure evoked parenchymal arteriole vasoconstriction star shaped cells help blood vessels in the brain keep a grip on a healthy tone alcohol risk management in college settings the safer california universities randomized trial campus community interventions successful in reducing college drinking rapid throughput skeletal phenotyping of knockout mice identifies new genes that determine bone strength close to the bone gene deletions in mice identifies nine new genes that determine bone strength association of early imaging for back pain with clinical outcomes in older adults early imaging for back pain in older adults not associated with better outcomes risk of incident diabetes associated with dose and duration of oral glucocorticoid therapy in patients with rheumatoid arthritis diabetes risk of common arthritis medicine quantified for first time economic evaluation of community based hiv prevention programs in ontario evidence of effectiveness in reducing hiv infections and health care costs money spent on community based hiv prevention translates into treatment savings risk factors for malnutrition among older adults in the emergency department a multicenter study poor oral health food scarcity major contributors to malnutrition in older adults twenty eight years of poliovirus replication in an immunodeficient individual impact on the global polio eradication initiative a patient shedding poliovirus for years possible challenges for polio eradication redox stratification of an ancient lake in gale crater mars rover findings indicate stratified lake on ancient mars rhinovirus wheezing illness and genetic risk of childhood onset asthma childhood asthma tied to combination of genes and wheezing illness endosomal nox oxidase exacerbates virus pathogenicity and is a target for antiviral therapy new research points to treatment breakthrough for viruses scanning skeletal remains for bone mineral density in forensic contexts bone experts offer how to video for forensic professionals the stereotypical computer scientist gendered media representations as a barrier to inclusion for women nerdy mold needs breaking to recruit women into computer science widespread tau and amyloid beta pathology many years after a single traumatic brain injury in humans single traumatic brain injury may prompt long term neurodegeneration dysregulated humoral immunity to nontyphoidal salmonella in hiv infected african adults hiv patients hold clues to salmonella vaccine development the interstitial duplication q. q syndrome includes autism mild facial anomalies and a characteristic eeg signature significant insights into common form of autism study identifies genetic connections in q duplication syndrome hallmarks of alzheimer disease are evolving relentlessly in metropolitan mexico city infants children and young adults. apoe carriers have higher suicide risk and higher odds of reaching nft stage v at years of age evidence mounts for alzheimer s suicide risks among youth in polluted cities effect of vitamin supplements on hiv shedding in breast milk vitamin a increases the presence of hiv in breast milk studies suggest neuregulin improves cognitive deficits and neuropathology in an alzheimer s disease model elevating brain protein allays symptoms of alzheimer s improves memory diagnostic inaccuracy of smartphone applications for melanoma detectionmelanoma detection using smartphone applications inaccurate diagnoses of melanoma by smartphone apps could delay doctor visits life saving treatment healthcare coverage for hiv provider visits before and after implementation of the affordable care act study underscores ongoing need for hiv safety net program ascorbate infusion increases skeletal muscle fatigue resistance in patients with chronic obstructive pulmonary disease vitamin c could ease muscle fatigue in copd patients high resolution seismic reflection imaging of growth folding and shallow faults beneath the southern puget lowland washington state potentially active faults near olympia washington state us identified the impact of fish and shellfish consumption on age related macular degeneration new evidence for eye protective effects of omega rich fish shellfish spiny plants mammal browsers and the origin of african savannas browsing antelope turned ancient african forests into grassy savanna ecosystems common polygenic variations for psychiatric disorders and cognition in relation to brain morphology in the general pediatric population genetic risk for adhd manifest in brain structure in childhood eradication of pseudomonas aeruginosa biofilms by atmospheric pressure non thermal plasma new plasma jet gives cold shoulder to superbugs the importance of auricular prostheses for speech recognition prosthetic ears appear to improve hearing and speech recognition in noisy environments the more you play the more aggressive you become a long term experimental study of cumulative violent video game effects on hostile expectations and aggressive behavior violent video games more playing time equals more aggression rapid determination of comparative drought tolerance traits using an osmometer to predict turgor loss point rapid assessment of plant drought tolerance possible with new method an auxin minimum triggers the developmental switch from cell division to cell differentiation in the arabidopsis root hormonal tug of war helps plant roots navigate their journey through the soil identification of targetable fgfr gene fusions in diverse cancers clinical sequencing technology identifies new targets in diverse cancers botulinum neurotoxins new questions arising from structural biology giving botox a safer facelift structures of botulinum neurotoxins studied lemurfaceid a face recognition system to facilitate individual identification of lemurs researchers design facial recognition system as less invasive way to track lemurs in wild changes in sexual functioning and sex hormone levels in women following bariatric surgery sexual function dramatically improves in women following bariatric surgery greater prevalence and incidence of dementia in older veterans with posttraumatic stress disorder ptsd and dementia more study needed to determine why veterans with ptsd are more at risk than others sub ewald curvature corrected structure of an aav capsid variant electron microscopy provides new view of tiny virus with therapeutic potential assessment of chronic sublethal effects of imidacloprid on honey bee colony health pesticides not sole culprit in honey bee colony declines regional and seasonal response of a west nile virus vector to climate change effects of climate change on west nile virus effectiveness of a scaled up physical activity intervention in brazil a natural experiment availability of community based fitness classes leads to increased activity levels employing high frequency alternating magnetic fields for the non invasive treatment of prosthetic joint infections magnetic fields turn up the heat on bacterial biofilms evidence of recent dengue exposure among malaria parasite positive children in three urban centers in ghana hidden burden of dengue fever in west africa loss of function mutation inloxcauses thoracic aortic aneurysm and dissection in humans discovery yields answers for family with thoracic aortic aneurysm and dissection effect of intervention aimed at increasing physical activity reducing sedentary behaviour and increasing fruit and vegetable consumption in children active for life year afly school based cluster randomised controlled trial school scheme unable to boost healthy eating activity among kids support for a neuropsychological model of spirituality in persons with traumatic brain injury selflessness core of all major world religions has neuropsychological connection astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells alzheimer s schizophrenia autism now have new research tool mature brain cells derived from skin cells decade long safety and function of retroviral modified chimeric antigen receptor t cells genetically modified t cell therapy appears to be safe lasting in decade long study of hiv patients explaining the geographical origins of seasonal influenza a h n new analysis explores the geographical origins of the flu the king devick test of rapid number naming for concussion detection meta analysis and systematic review of the literature vision testing an effective tool for detecting concussion on the sidelines circulating hydroxyvitamin d levels and frailty status in older women low and high vitamin d levels in older women associated with increased likelihood of frailty neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model and its pharmacokinetics in rats active ingredient of aconite root against peripheral neuropathic pain is identified as neoline testosterone treatment and sexual function in older men with low testosterone levels testosterone therapy improves sexual interest function in older men direct numerical simulation of cellular scale blood flow in d microvascular networks the complex journey of red bloods cells through microvascular networks initiation of traditional cigarette smoking after electronic cigarette use among tobacco na ve u.s. young adults e cig use increases risk of beginning tobacco cigarette use in young adults usf deficiency activates brown adipose tissue and improves cardiometabolic health slender mice heart disease and diabetes what do they have in common ? prevalence of overweight and obesity and some associated factors among adult residents of northeast china a cross sectional study in overweight and in obese in north east china jilin province his corrective pacing or biventricular pacing for cardiac resynchronization in heart failure treatment to restore natural heartbeat could be on the horizon for heart failure multiparity improves outcomes after cerebral ischemia in female mice despite features of increased metabovascular risk giving birth multiple times has impact on stroke recovery study shows health care volunteers and disaster response u first be prepared health care volunteers and disasters first be prepared bivalent brain shuttle increases antibody uptake by monovalent binding to the transferrin receptor new research study creates new opportunities for treating brain diseases two knockdown models of the autism genes syngap and shank in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis zebrafish model gives new insight on autism spectrum disorder phase ii trial of dendritic cells loaded with antigens from self renewing proliferating autologous tumor cells as patient specific anti tumor vaccines in patients with metastatic melanoma cancer vaccines led to long term survival for patients with metastatic melanoma urogenital infection as a risk factor for male infertility male infertility urogenital infection as a possible cause estimation of the intrinsic birefringence of cellulose using bacterial cellulose nanofiber films from nata de coco to computer screens cellulose gets a chance to shine the adikeshavus group a new species group of idris f rster hymenoptera platygastridae from india with descriptions of five new species the first long haired ones new wasp group proposed for five new species from india association of insulin resistance with cerebral glucose uptake in late middle aged adults at risk for alzheimer disease insulin resistance increases risk for alzheimer s disease study finds angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels blood pressure drug may help improve cancer treatment exposure and food web transfer of pharmaceuticals in ospreys pandion haliaetus predictive model and empirical data pharmaceuticals and the water fish osprey food web in vivo activation of the sk channel in the spinal cord reduces the nmda receptor antagonist dose needed to produce antinociception in an inflammatory pain model key mechanism of chronic inflammatory pain discovered that could reduce drug doses incidence and determinants of traumatic intracranial bleeding among older veterans receiving warfarin for atrial fibrillation incidence risk factors for intracranial bleeding in older adults newly prescribed warfarin local variability mediates vulnerability of trout populations to land use and climate change local habitat conditions can safeguard cutthroat trout against harvest climate change genetic relationship between five psychiatric disorders estimated from genome wide snps new data reveal extent of genetic overlap between major mental disorders plastic surgery related hashtag utilization on instagram implications for education and marketing barbers hair salons market cosmetic surgery on instagram pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of parkinson s disease new technique negotiates neuron jungle to target source of parkinson s disease fructose decreases physical activity and increases body fat without affecting hippocampal neurogenesis and learning relative to an isocaloric glucose diet fructose contributes to weight gain physical inactivity and body fat researchers find sterile particle induced inflammation is mediated by macrophages releasing il through a bruton s tyrosine kinase dependent pathway cause of bone loss in joint implant patients uncovered in new study transparent intracortical microprobe array for simultaneous spatiotemporal optical stimulation and multichannel electrical recording new optoelectronic probe enables communication with neural microcircuits microwell devices with finger like channels for long term imaging of hiv expression kinetics in primary human lymphocytes scientists develop technique to decipher the dormant aids virus concealed in cells cellular hypoxia promotes heterotopic ossification by amplifying bmp signaling quieting cells low oxygen alarm stops flare ups in rare bone disorder herbivory in spiders the importance of pollen for orb weavers spiders are partial to a side order of pollen with their flies functional segregation of basal ganglia pathways in parkinson s disease effects of deep brain stimulation in patients with parkinson s disease deterministic quantum emitter formation in hexagonal boron nitride via controlled edge creation scientists drill into white graphene to create artificial atoms cardiometabolic risk of second generation antipsychotic medications during first time use in children and adolescents use of antipsychotic medications by children and adolescents associated with significant weight gain lower risk of cardiovascular events in postmenopausal women taking oral estradiol compared with oral conjugated equine estrogens two common estrogen drugs compared regarding cardiovascular safety fingerprints of sea level rise on changing tides in the chesapeake and delaware bays century of data shows sea level rise shifting tides in delaware chesapeake bays selection of a multidrug resistance plasmid by sublethal levels of antibiotics and heavy metals very low concentrations of heavy metals antibiotics contribute to resistance effect of mindfulness based stress reduction vs cognitive behavioral therapy or usual care on back pain and functional limitations in adults with chronic low back pain use of mindfulness based stress reduction for chronic low back pain receptivity to and recall of alcohol brand appearances in u.s. popular music and alcohol related behaviors crafty alcohol advertising directed at us adolescents through music branding canonical wnt signaling ameliorates aging of intestinal stem cells old gut stem cells made to grow like young ones in a dish a pilot online survey assessing risk factors for hiv acquisition in the navy and marine corps study looks at risk factors for hiv in u.s. navy and marines during don t ask don t tell desmoglein deficiency results in severe dermatitis multiple allergies and metabolic wasting skin cell defect is surprising allergy trigger skin and food allergies can be result of skin cell glue deficiency maternal immune activation during pregnancy alters the behavior profile of female offspring of sprague dawley rats viral infections during pregnancy linked to behavioral abnormalities in offspring a new deep reef scorpionfish teleostei scorpaenidae scorpaenodes from the southern caribbean with comments on depth distributions and relationships of western atlantic members of the genus scorpionfish too deep for scuba divers caught by submersible turns out to be a new species time resolved million year old supernova activity discovered in earth s microfossil record earth interacted with supernova remnants for million years web reduction by courting male black widows renders pheromone emitting females webs less attractive to rival males male black widow spiders destroy female s web to deter rivals effects of prenatal exposure to air pollutants polycyclic aromatic hydrocarbons on the development of brain white matter cognition and behavior in later childhood prenatal exposure to common air pollution linked to cognitive behavioral impairment structure of a symmetric photosynthetic reaction center photosystem new picture emerges on the origins of photosynthesis in sun loving bacteria seismic images of the biggest crash on earth the biggest crash on earth india slides under tibet but how ? financial capabilities among youth with autism spectrum disorder money a barrier to independence for young adults with autism e and e antibody levels are potential biomarkers of recurrence in patients with advanced stage human papillomavirus positive oropharyngeal squamous cell carcinoma predicting throat cancer recurrence with a blood test copsin a novel peptide based fungal antibiotic interfering with the peptidoglycan synthesis new antibiotic in mushroom that grows on horse dung representations of cosmetic surgery and emotional health in women s magazines in canada women s magazines downplay emotional health risks of cosmetic surgery study finds trans blood brain barrier delivery of dopamine loaded nanoparticles reverses functional deficits in parkinsonian rats nanoparticle drug reverses parkinson s like symptoms in rats cost effectiveness of comprehensive integrated care for first episode psychosis in the nimh raise early treatment program team based treatment for first episode psychosis found to be high value bimodal control of dendritic and axonal growth by the dual leucine zipper kinase pathway neuronal regeneration and the two part design of nerves trajectories of risky drinking around the time of statutory retirement a longitudinal latent class analysis risky alcohol consumption can increase at time of retirement crying wolf ? a spatial analysis of wolf location and depredations on calf weight wolf predation of cattle affects calf weight in montana chronic enrichment of hepatic endoplasmic reticulum mitochondria contact leads to mitochondrial dysfunction in obesity excessive contact between cellular organelles disrupts metabolism in obesity the slide hammer seeder a novel tool for planting small seeds planting small seeds simply the allure of the slide hammer seeder perceived mathematical ability under challenge a longitudinal perspective on sex segregation among stem degree fields misperception discourages girls from studying some stem fields does legislation to prevent alcohol sales to drunk individuals work ? measuring the propensity for night time sales to drunks in a uk city uk law to stop further sales of booze to drunk customers routinely flouted tlr mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination intestinal bacteria needed for strong flu vaccine responses in mice functional characterization of the odorant receptor e in human melanocytes olfactory receptor discovered in pigment cells of the skin infrasonic and ultrasonic hearing evolved after the emergence of modern whales extinct early whales listened like their relatives on land fossil evidence shows murine and human tissue engineered esophagus form from sufficient stem progenitor cells and do not require microdesigned biomaterials first step from human cells to tissue engineered esophagus visualization of nmda receptor dependent ampa receptor synaptic plasticity in vivo scientists view effect of whisker tickling on mouse brains direct write liquid phase transformations with a scanning transmission electron microscope electron beam microscope directly writes nanoscale features in liquid with metal ink tocopherol disappearance rates from plasma depend on lipid concentrations studies using deuterium labeled collard greens in younger and older adults high cholesterol triglycerides can keep vitamin e from reaching body tissues increased local retention of reef coral larvae as a result of ocean warming more coral babies staying at home on future reefs association between hepatic triglyceride content and left ventricular diastolic function in a population based cohort the netherlands epidemiology of obesity study study links fatty liver heart failure in obese people specific dietary fats in relation to total and cause specific mortality higher consumption of unsaturated fats linked with lower mortality rates stalls in africa s fertility decline partly result from disruptions in female education stalled fertility declines linked to disruptions in women s education in africa smartphones are bad for some teens not all smartphones bad for some teens but not all expert says production of methane and ethylene from plastic in the environment degrading plastics revealed as source of greenhouse gases acupuncture for fibromyalgia in primary care a randomised controlled trial tailored acupuncture lessens pain intensity in chronic pain fibromyalgia introduction of ranavirus to isolated wood frog populations could cause local extinction ranavirus predicted to be potential new culprit in amphibian extinctions reparative effects of interleukin receptor antagonist in young and aged co morbid rodents after cerebral ischemia new drug limits and then repairs brain damage in stroke the effect of mass immunisation campaigns and new oral poliovirus vaccines on the incidence of poliomyelitis in pakistan and afghanistan a retrospective analysis polio vaccination programs not reaching enough children in afghanistan and pakistan neuroligin drives synaptic and behavioral maturation through intracellular interactions over produced autism gene alters synapses affects learning and behavior in mice advances in neglected tropical disease vaccines developing relative potency and functional assays for the na gst alhydrogel hookworm vaccine testing program monitors stability of vaccines for neglected tropical diseases molecular profiling reveals unique immune and metabolic features of melanoma brain metastases melanoma brain metastases are immunosuppressive with treatment resistant metabolism learning to expect the unexpected rapid updating in primate cerebellum during voluntary self motion our elegant brain motor learning in the fast lane vegetarian dietary patterns and the risk of colorectal cancers vegetarian diet linked to lower risk of colorectal cancers differential contributions of endogenous and exogenous nutrients to egg components in wild baltic common eiders somateria mollissima a test of alternative stable isotope approaches arctic ducks combine nutrients from wintering breeding grounds to grow healthy eggs hierarchically patterned polydopamine containing membranes for periodontal tissue engineering new technique could help regrow tissue lost to periodontal disease clinical and mri outcomes after platelet rich plasma treatment for knee osteoarthritis platelet rich plasma prp treatment shows potential for knee osteoarthritis experience with speech sounds is not necessary for cue trading by budgerigars melopsittacus undulatus budgerigars can identify spoken sounds without prior exposure to human speech targeted administration into the suprachoroidal space using a microneedle for drug delivery to the posterior segment of the eye microneedles target therapeutics to back of the eye male sagebrush lizards sceloporus graciosus increase exploratory behavior toward females with more courtship experience experienced female lizards attract greater attention from male lizards high mortality among patients with opioid use disorder in a large healthcare system alarmingly high risk of death for people with opioid use disorder in general medical care clinical evaluation of a microwave based device for detection of traumatic intracranial hemorrhage microwave helmet yields fast safe evaluation of head injuries superinfection of sows with cystoisospora suis ante partum leads to a milder course of cystoisosporosis in suckling piglets protective milk shot how mother s milk protects piglets from parasite infections sleep patterns and insomnia in young adults a national survey of norwegian university students sleep problems in young adult students revealed in new study combining global climate and regional landscape models to improve prediction of invasion risk invasive species in waterways on rise due to climate change reinforcement learning recruits somata and apical dendrites across layers of primary sensory cortex brain s primitive sensory region also participates in sophisticated learning trends over time in tobacco specific nitrosamines tsnas in whole tobacco and smoke emissions from cigarettes sold in canada study finds failure to sustain reductions in carcinogens in cigarettes blood lead levels and major depressive disorder panic disorder and generalized anxiety disorder in us young adults young adults blood lead levels linked to depression panic disorder us spending on personal health care and public health diabetes heart disease and back pain dominate us health care spending caution reptile pets shuttle grasshopper allergy and asthma into homes reptile pets food insects shuttle allergens into homes novel reovirus associated with epidemic mortality in wild largemouth bass micropterus salmoides new virus found during investigation into largemouth bass fish kill on and off retinal circuit assembly by divergent molecular mechanisms critical gene in retinal development and motion sensing identified gender related influences of parental alcoholism on the prevalence of psychiatric illnesses analysis of the national epidemiologic survey on alcohol and related conditions gender related influences of parental alcoholism genders of alcohol dependent parents and children influence psychopathology in the children how cats lap water uptake by felis catus cats show perfect balance even in their lapping effect of late life weight change on dementia incidence a year cohort study using claim data in korea weight gain and loss may worsen dementia risk in older people transient ionization of the mesosphere during auroral breakup arase satellite and ground based conjugate observations at syowa station shedding light on the science of auroral breakups processed and unprocessed red meat consumption and risk of heart failure a prospective study of men processed red meat linked to higher risk of heart failure death in men dried plum diet protects from bone loss caused by ionizing radiation dried plums provide protection from bone loss due to radiation study shows high dose inactivated influenza vaccine is associated with cost savings and better outcomes compared to standard dose inactivated influenza vaccine in canadian seniors high dose influenza vaccine is expected to provide cost savings and better outcomes compared to standard dose influenza vaccine in canadian seniors mercury offloaded in northern elephant seal hair affects coastal seawater surrounding rookery molting elephant seals add mercury to coastal seawater punk s not dead. fungi for tinder at the neolithic site of la draga ne iberia identifying the use of tinder fungi among neolithic communities at la draga evidence for hiv associated b cell exhaustion in a dysfunctional memory b cell compartment in hiv infected viremic individuals exhausted b cells hamper immune response to hiv forecasting domestic violence a machine learning approach to help inform arraignment decisions machine learning at arraignments can cut repeat domestic violence genetics and the environment affect the relationship between depression and low back pain twin study lends new insights into link between back pain and depression volumetric analysis of cerebellum in short track speed skating players skaters brains specialized training of complex motor skills may induce sports specific structural changes in cerebellum racial differences inbraf krasmutation rates and survival in stage iii colon cancer patients genes of colon cancer recurrence differs among blacks whites and asians enantiomorphing chiral plasmonic nanostructures a counterintuitive sign reversal of the nonlinear circular dichroism morphing twisted nanoscale objects to tailor applications in future technologies impact of insurance status on migraine care in the united states a population based study people with no health insurance get substandard migraine care study finds association of child abuse exposure with suicidal ideation suicide plans and suicide attempts in military personnel and the general population in canada child abuse exposure suicidal ideation in canadian military general population identification of genetic variants associated with huntington s disease progression a genome wide association study genetic modifier for huntington s disease progression identified guns in intimate partner violence comparing incidents by type of weapon new research examines gun use injury and fear in domestic violence early life cockroach allergen and polycyclic aromatic hydrocarbon exposures predict cockroach sensitization among inner city children air pollution primes children for asthma related cockroach allergy comparative effectiveness of combined digital mammography and tomosynthesis screening for women with dense breasts tomosynthesis improves cancer detection in women with dense breast tissue sea level probability for the last deglaciation a statistical analysis of far field records global sea level rise at the end of the last ice age interrupted by rapid jumps unusually complex phase of dense nitrogen at extreme conditions intense tests reveal elusive complex form of nitrogen a synthetic binder of breast cancer stem cells scientists isolate cancer stem cells using novel method spherical nucleic acid nanoparticle conjugates as an rnai based therapy for glioblastoma incurable brain cancer gene silenced gene regulation technology increases survival rates in mice with glioblastoma hell and high water practice relevant adaptation science preparing for hell and high water researchers advocate for climate adaptation science programmed assembly of dimensional microtissues with defined cellular connectivity assembling cells into artificial d microtissues including a tiny gland partial saturation of menaquinone inmycobacterium tuberculosis function and essentiality of a novel reductase menj powering off tb new electron transport gene is a potential drug target comparative genomics of the mimicry switch in papilio dardanus african swallowtail butterfly genetic secrets of nature s master of mimicry unraveled the purification and characterization of atp synthase complexes from the mitochondria of four fungal species purification characterization of atp synthase complexes from mitochondria of four fungal species risk of metachronous high risk adenomas and large serrated polyps in individuals with serrated polyps on index colonoscopy data from the new hampshire colonoscopy registry serrated polyps plus conventional adenomas may mean higher risk for colorectal cancer characterization of uterine leiomyomas by whole genome sequencing findings on onset of uterine fibroids provide potential for novel treatments urban farmers markets accessibility offerings and produce variety quality and price compared to nearby stores price variety and junk food study finds urban farmers markets may fall short compared to neighborhood stores fine particulate matter and respiratory healthcare encounters among survivors of childhood cancers air pollution poses risks for childhood cancer survivors total mercury and methylmercury response in water sediment and biota to destratification of the great salt lake utah united states mystery of the missing mercury at the great salt lake suicide fatal injuries and other causes of premature mortality in patients with traumatic brain injury head injuries triple long term risk of early death co option and de novo gene evolution underlie molluscan shell diversity shell game understanding gene patterns behind mollusk diversity effects of violent video game exposure on aggressive behavior aggressive thought accessibility and aggressive affect among adults with and without autism spectrum disorder violent video games not linked to aggression in adults with autism outcomes of repeat colonoscopy in patients with polyps referred for surgery without biopsy proven cancer study examines repeat colonoscopy in patients with polyps referred for surgery without biopsy proven cancer identification of a major genetic determinant of glycaemic index in rice good news about the glycemic index of rice longitudinal morphological and performance profiles for american ncaa division i football players through four years training college football players gain strength and size oral narrative skills explaining the language emergent literacy link by race ethnicity and ses. storytelling skills support early literacy for african american children impact on predictability of tropical and mid latitude cyclones by extra arctic observations extra arctic observations can improve predictability of tropical cyclones therapeutic radiation for childhood cancer drives structural aberrations of nf in meningiomas brain tumor scientists map mutation that drives tumors in childhood cancer survivors the relationship between adherence to oral antibiotics and post discharge clinical outcomes among patients hospitalized withstaphylococcus aureusskin infections patients with skin infections fail to complete antibiotics leading to poor outcomes dominant mutations in grhl cause van der woude syndrome and disrupt oral periderm development new gene responsible for cleft lip palate syndrome identified intraoperative visualization of the tumor microenvironment and quantification of extracellular vesicles by label free nonlinear imaging novel imaging technique brings diagnostic potential into operating room vasodynamics of pial and penetrating arterioles in relation to arteriolo arteriolar anastomosis after focal stroke reducing stroke damage may be next for optical coherence tomography technology widely used in vision healthcare maternal influenza immunization and reduced likelihood of prematurity and small for gestational age births a retrospective cohort study link between influenza vaccination in pregnancy and reduced risk of premature birth sensitive periods for the effect of childhood adversity on dna methylation results from a prospective longitudinal study adverse events during first years of life may have greatest effect on future mental health physiologic responses and energy expenditure of kinect active video game play in schoolchildren active video gaming linked with higher energy expenditure in children locus specific epigenetic remodeling controls addiction and depression related behaviors changes in single gene s action can control addiction and depression related behaviors delirium severity post surgery and its relationship with long term cognitive decline in a cohort of patients without dementia severity of post operative delirium relates to severity of cognitive decline nitrate anion recognition in organic aqueous solvent mixtures by a bis triazolium acridine containing rotaxane pioneering method in the evaluation of nitrate pollution sex biased survival contributes to population decline in a long lived seabird the magellanic penguin why the number of single male magellanic penguins is rising at this breeding colony effect of assertive outreach after suicide attempt in the aid assertive intervention for deliberate self harm trial randomised controlled trial close contact with young people at risk of suicide has no effect study suggests our footprint on antarctica competes with nature for rare ice free land human footprint on antarctica measured for first time reconstructing the origin and spread of horse domestication in the eurasian steppe mystery of the domestication of the horse solved competing theories reconciled association between nonmedical use of prescription drugs and suicidal behavior among adolescents study of chinese teens examines nonmedical use of prescription drugs suicidal behaviors effect of integrated behavioral weight loss treatment and problem solving therapy on body mass index and depressive symptoms among patients with obesity and depressionthe rainbow randomized clinical trial integrated therapy treating obesity and depression is effective mutations in cytosine trna methyltransferases impact mobile element expression and genome stability at specific dna repeats stress induced changes in genetic information new details discovered about the function of a mysterious protein anthropogenic extinction dominates holocene declines of west indian mammals caribbean islands reveal a lost world of ancient mammals empirical evidence of fall spawning by atlantic sturgeon in the james river virginia fall spawning by atlantic sturgeon in virginia river holographic imaging of electromagnetic fields via electron light quantum interference new holographic technique opens the way for quantum computation a simple low cost conductive composite material for d printing of electronic sensors engineers pave the way towards d printing of personal electronics psychological factors associated with uptake of the childhood influenza vaccine and perception of post vaccination side effects a cross sectional survey in england parental concerns reduce uptake of child flu vaccine solar driven reforming of lignocellulose to h with a cds cdox photocatalyst scientists harness solar power to produce clean hydrogen from biomass adaptive reprogramming of de novo pyrimidine synthesis is a metabolic vulnerability in triple negative breast cancer vulnerability in triple negative breast cancer could improve treatment outcomes breast milk protects against the development of necrotizing enterocolitis through inhibition of toll like receptor in the intestinal epithelium via activation of the epidermal growth factor receptor how breast milk protects against severe intestinal disease in preemies current status of implant based breast reconstruction in patients receiving postmastectomy radiation therapy implant based breast reconstruction following radiation has high patient satisfaction rate despite complications transcriptomic identification of starfish neuropeptide precursors yields new insights into neuropeptide evolution starfish reveal the origins of brain messenger molecules underdiagnosis of mild cognitive impairment a consequence of ignoring practice effects practice imperfect repeated cognitive testing can obscure early signs of dementia a common embryonic origin of stem cells drives developmental and adult neurogenesis researchers discover the source of new neurons in brain s hippocampus a shared population of epidemic methicillin resistant staphylococcus aureus circulates in humans and companion animals humans and companion animals harbor the same types of mrsa infections halomonas sulfidaeris dominated microbial community inhabits a. km deep subsurface cambrian sandstone reservoir oil and metal munching microbes dominate deep sandstone formations evaluation of antipathogenic activity and adherence properties of humanlactobacillusstrains for vaginal formulations probiotic treatment for vaginal thrush on the way uplift rate transients at subduction margins due to earthquake clustering earthquake series cause uplift variations at continental margins outcomes of the botanical nomenclature section at the xviii international botanical congress electronic publishing goes live news from the international botanical congress in melbourne phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations metastatic breast cancers characterizing the profile of metastases for improved treatment totipotent embryonic stem cells arise in ground state culture conditions rewinding development a step forward for stem cell research hsf mediated cytoskeletal integrity determines thermotolerance and life span new front in war on alzheimer s other protein linked brain diseases rad sequencing highlights polygenic discrimination of habitat ecotypes in the panmictic american eel genetic analysis of the american eel helps explain its decline comparative biomechanical modeling of metatherian and placental saber tooths a different kind of bite for an extreme pouched predator curious mix of precision and brawn in a pouched super predator early puberty friendship group characteristics and dating abuse in us girls friendship group influences dating violence risk for early maturing girls association of antiepileptic drugs with nontraumatic fractures a population based analysis anti epileptic drugs associated with increased risk of fracture in older adults a look at person centered and family centered care among older adults results from a national survey four in ten older adults burdened by demands of health care system temporal variation in pelagic food chain length in response to environmental change climate shifts shorten marine food chain off california survival durable tumor remission and long term safety in patients with advanced melanoma receiving nivolumab immune system based therapy produces lasting remissions in melanoma patients study reports a glycoconjugate of haemophilus influenzae type b capsular polysaccharide with tetanus toxoid protein hydrodynamic properties mainly influenced by the carbohydrate improving modern vaccines sugar polymer tails wag the protein dog attention deficit hyperactivity disorder after early exposure to procedures requiring general anesthesia young children exposed to anesthesia multiple times show elevated rates of adhd validity of a minimally invasive autopsy tool for cause of death determination in pediatric deaths in mozambique an observational study minimally invasive autopsy can identify causes of mozambique newborn and childhood deaths clinical and molecular characterization of her amplified pancreatic cancer potential treatment for a specific kind of pancreatic cancer inequity in consumption of goods and services adds to racial ethnic disparities in air pollution exposure us black and hispanic minorities bear disproportionate burden from air pollution fragranced consumer products exposures and effects from emissions fragranced products risks for people and profits ? vitamin d associates with improved quality of life in participants with irritable bowel syndrome outcomes from a pilot trial large proportion of ibs sufferers are vitamin d deficient epilepsy and the subsequent risk of cerebral tumour record linkage retrospective cohort study epileptic seizures linked to significant risk of subsequent brain tumor dual impact of elevated temperature on plant defence and bacterial virulence in arabidopsis fighting plant disease at warm temperatures keeps food on the table a larger social network enhances novel object location memory and reduces hippocampal microgliosis in aged mice social ties could preserve memory slow brain aging does genomic variation in a foundation species predict arthropod community structure in a riparian forest ? predicting an insect community structure based on genomic variation in a tree species pharmacologic reversion of epigenetic silencing of the prkd promoter blocks breast tumor cell invasion and metastasis drug used for blood cancers may stop spread of breast cancer cells the unique effects of fathers warmth on adolescents positive beliefs and behaviors pathways to resilience in low income families a father s influence makes for better grades design of acoustic beam aperture modifier using gradient index phononic crystals new metamaterials device focuses sound waves like a camera lens the influence of excessive chewing gum use on headache frequency and severity among adolescents chewing gum is often culprit for migraine headaches in teens microorganism mediated synthesis of reduced graphene oxide films graphene produced using microorganisms from an ordinary river determinants of mortality among postmenopausal women who report rheumatoid arthritis in the women s health initiative higher mortality in postmenopausal women with ra and anti ccp antibodies northward expansion and intensification of phytoplankton growth during the early ice free season in arctic arctic sea ice decline driving ocean phytoplankton farther north workplace incivility ruins my sleep and yours the costs of being in a work linked relationship a co worker s rudeness can affect your sleep and your partner s induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation stem cells used to model disease that causes abnormal bone growth association between media use in adolescence and depression in young adulthood teen media exposure associated with depression symptoms in young adulthood favourable effects of fenofibrate on lipids and cardiovascular disease in women with type diabetes results from the fenofibrate intervention and event lowering in diabetes field study cholesterol drug cuts heart stroke risks by percent in diabetic women study science that matters the importance of a cultural connection in underrepresented students science pursuit young gifted first generation minority science students motivated by prosocial values biomarkers of cerebral injury and inflammation in pediatric tuberculous meningitis biological fingerprint of tuberculosis meningitis discovered in children reducing sexual victimization among adolescent girls a randomized controlled pilot trial of my voice my choice teen girls report less sexual victimization after virtual reality assertiveness training long lived hot carrier light emission and large blue shift in formamidinium tin triiodide perovskites slow hot electrons could improve solar cell efficiency effects of prenatal exposure to a low dose atrazine metabolite mixture on pubertal timing and prostate development of male long evans rats widely used herbicide atrazine causes prostate inflammation in male rats and delays puberty association of cigarette price differentials with infant mortality in european union countries budget cigarettes linked to higher infant mortality rates in eu countries early menopause and risk of osteoporosis fracture and mortality a year prospective observational study in women early menopause linked to higher risk of osteoporosis fracture and mortality uv radiation limited the expansion of cyanobacteria in early marine photic environments iron silica particles unlock part of the mystery of earth s oxygenation a t translocation is the likely driver of a syndrome with ambiguous genitalia facial dysmorphism intellectual disability and speech delay from molecular case studies novel syndrome resulting from multiple genomic lesions long term realism and cost effectiveness primary prevention in combatting cancer and associated inequalities worldwide rising cancer rates in low middle income countries threaten economic stability secular trends in the prevalence of female genital mutilation cutting among girls a systematic analysis huge fall in prevalence of fgm genital cutting among girls across africa preliminary evidence for mediation of the association between acculturation and sun safe behaviors study examines relationship of acculturation with sun safe behaviors of us latinos antibodies specific for a segment of human membrane ige deplete ige producing b cells in humanized mice eliminating the source of asthma causing immune molecules consequences of zygote injection and germline transfer of mutant human mitochondrial dna in mice scientists test new gene therapy for vision loss from a mitochondrial disease maternal and paternal age are jointly associated with childhood autism in jamaica both maternal and paternal age linked to autism impact of maternal and child race on maternal ratings of adhd symptoms in black and white boys african american mothers rate boys higher for adhd deceleration capacity of heart rate as a predictor of mortality after myocardial infarction cohort study telling irregularities new procedure uses heart rate to estimate the life expectancy of infarct patients sprouting of brainstem spinal tracts in response to unilateral motor cortex stroke in mice brainstem discovered as important relay site after stroke hoyeraal hreidarsson syndrome caused by a germline mutation in the tel patch of the telomere protein tpp disease decoded gene mutation may lead to development of new cancer drugs a simple measure of human development the human life indicator new measure for the wellbeing of populations could replace human development index trends in cannabis and cigarette use among parents with children at home to cannabis use up among parents with children in the home competition for shrinking window of low salinity groundwater us groundwater in peril potable supply less than thought outcomes associated with influenza vaccination in the first year after kidney transplantation green light for flu vaccine in transplant recipients study suggests potent in vitro antiviral activity of cistus incanus extract against hiv and filoviruses targets viral envelope proteins cell culture experiments reveal potent antiviral activity of cistus incanus extracts against hiv and ebola notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the wnt pathway blocking notch pathway leads to new route to hair cell regeneration to restore hearing temporal trends in and factors associated with contralateral prophylactic mastectomy among us men with breast cancer prophylactic surgery nearly doubles in men with breast cancer expanding wetland mitigation can rice fields remediate pesticides in agricultural runoff ? can rice filter water from agricultural fields ? quantitative analysis of antimicrobial use on british dairy farms experts advise using benchmarking to identify farms with high antibiotic use bcl a is a triple negative breast cancer gene with critical functions in stem and progenitor cells novel breast cancer gene found bcl a is active in difficult to treat triple negative breast cancer translating weight loss and physical activity programs into the community to preserve mobility in older obese adults in poor cardiovascular health weight loss plus walking essential for older obese adults transplantation of specific human astrocytes promotes functional recovery after spinal cord injury spinal cord injury human cells derived from stem cells restore movement in animal models human enterovirus species b in ileocecal crohn s disease link shown between crohn s disease and virus cell cycle networks link gene expression dysregulation mutation and brain maldevelopment in autistic toddlers altered cell cycle gene activity underlies brain overgrowth in autistic toddlers an fak yap mtor signaling axis regulates stem cell based tissue renewal in mice mouse teeth providing new insights into tissue regeneration a process based approach to estimate lodgepole pine pinus contorta dougl. distribution in the pacific northwest under climate change climate change causing demise of lodgepole pine in western north america the prognostic effects of somatic mutations in er positive breast cancer new clues found to understanding relapse in breast cancer mechanical regulation of vascular growth and tissue regeneration in vivo hold your forces mechanical stress can help or hinder wound healing depending on time of application metformin prevents the development of oral squamous cell carcinomas from carcinogen induced premalignant lesions metformin may lower risk for oral cancer development long term accumulation and transport of anthropogenic phosphorus in three river basins fertilizer s legacy taking a toll on land and water statin use is associated with a decreased risk of barrett s esophagus statin use decreases risk of barrett s esophagus study shows psychiatric advanced practice nurses contributions to supporting survivors and caregivers affected by the boston marathon bombings psychiatric nursing specialists played key role in response to boston marathon bombing apob ldl acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes bad cholesterol inhibits the breakdown of peripheral fat plastic surgery applications using three dimensional planning and computer assisted design and manufacturing d analysis and cad cam techniques lead to new advances in plastic and reconstructive surgery implementation research for early childhood development programming in humanitarian contexts do childhood development programs help children living in conflict and crisis settings ? analysis of human sequence data reveals two pulses of archaic denisovan admixture modern humans interbred with denisovans twice in history a novel unstable duplication upstream of has predisposes to a breed defining skin phenotype and a periodic fever syndrome in chinese shar pei dogs a mutation causing wrinkled skin of shar pei dogs is linked to periodic fever disorder the bacterially produced metabolite violacein is associated with survival of amphibians infected with a lethal fungus bacterially produced antifungal on skin of amphibians may protect against lethal fungus northern hemisphere hydroclimate variability over the past twelve centuries large variations in precipitation over the past millennium how much groundwater did california s central valley lose during the drought ? groundwater loss tracked during drought in california s central valley measles containing vaccines and febrile seizures in children age to years measles containing vaccines not linked with increased risk of febrile seizures in kids rapid and persistent adaptability of human oculomotor control in response to simulated central vision loss human eye movements for vision are remarkably adaptable single vs double lung transplantation in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis since the implementation of lung allocation based on medical need outcomes of lung transplantations since implementation of need based allocation system all fiber self compensating polarization encoder for quantum key distribution new all fiber device simplifies free space based quantum key distribution a single atom electron spin qubit in silicon single atom writer a landmark for quantum computing the emergence of modern sea ice cover in the arctic ocean emergence of modern sea ice in arctic ocean. million years ago an individual level meta analysis assessing the impact of community level sanitation access on child stunting anemia and diarrhea evidence from dhs and mics surveys sanitation access linked to children s growth and health sleep disturbance in osteoarthritis linkages with pain disability and depressive symptoms vicious cycle in osteoarthritis sleep disturbance pain depression disability insights into salt tolerance from the genome of thellungiella salsuginea salt cress genome yields new clues to salt tolerance association of cognitive function with amyloid and tau proteins in the vitreous humor study finds test of protein levels in the eye a potential predictor of future alzheimer s disease changes in salmon oncorhynchus keta flesh quality following ultra high pressure treatment and d of chilled storage ultra high pressure processing may increase salmon shelf life retinaldehyde dehydrogenase regulates a thermogenic program in white adipose tissue turning bad fat into good a new candidate pathway for treating visceral obesity a hierarchical coherent gene group model for brain development novel studies of gene regulation in brain development may mean new treatment of mental disorders the role of first semester gpa in predicting graduation rates of underrepresented students first semester gpa a better predictor of college success than act score neutrophil mobilization via plerixafor mediated cxcr inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow scientists bring to light mechanism of drug action do managed bees drive parasite spread and emergence in wild bees ? managed bees spread and intensify diseases in wild bees effect of supplemental donor human milk compared with preterm formula on neurodevelopment of very low birth weight infants at months supplemental nutrient enriched donor milk does not improve neurodevelopment in very low birth weight infants deletion of macrophage vitamin d receptor promotes insulin resistance and monocyte cholesterol transport to accelerate atherosclerosis in mice vitamin d helps immune cells prevent atherosclerosis diabetes parity and risk of maternal cardiovascular disease a dose response meta analysis of cohort studies giving birth associated with percent higher risk of heart disease and stroke engineering long shelf life multi layer biologically active surfaces on microfluidic devices for point of care applications new method to preserve microfluidic devices for hiv monitoring in developing countries cornus elwinortonii and cornus rutgersensis cornaceae new names for two artificially produced hybrids of big bracted dogwoods world famous yet nameless hybrid flowering dogwoods named by scientists association of educational attainment with lifetime risk of cardiovascular disease is educational attainment associated with lifetime risk of cardiovascular disease ? central acting therapeutics alleviate respiratory weakness caused by heart failure induced ventilatory overdrive cause of breathlessness in heart failure patients discovered escape gaps in african basket traps reduce bycatch while increasing body sizes and incomes in a heavily fished reef lagoon building a better fish trap reducing fish bycatch with escape gaps in africa novel wildlife in the arctic the influence of changing riparian ecosystems and shrub habitat expansion on snowshoe hares shrubs on warming north slope attract moose hares a dual molecular analogue tuner for dissecting protein function in mammalian cells new tool enables researchers to rapidly manipulate protein levels in mammalian cells genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis a new streamlined approach to diagnosing and treating bowel cancer the predatory ecology of deinonychus and the origin of flapping in birds dinosaurs with killer claws yield new theory about evolution of flight how new caledonian crows solve novel foraging problems and what it means for cumulative culture something to crow about new caledonian crows show strong evidence of social learning are financial incentives cost effective to support smoking cessation during pregnancy ? new study finds financial incentives to help pregnant women stop smoking are highly cost effective isotopic evidence for microbial production and consumption of methane in the upper continental crust throughout the phanerozoic eon methane munching microbes living in the deep biosphere for million years an analogue for extra terrestrial life nanorobotic investigation identifies novel visual structural and functional correlates of autoimmune pathology in a blistering skin disease model how skin falls apart pathology of autoimmune skin disease revealed at the nanoscale a fully integrated nanosystem of semiconductor nanowires for direct solar water splitting artificial forest for solar water splitting first fully integrated artificial photosynthesis nanosystem recovery and reproduction of an antarctic tardigrade retrieved from a moss sample frozen for over years animals revived after being in a frozen state for over years pagan symbols associated with the female anatomy in the medici chapel by michelangelo buonarroti michelangelo s medici chapel may contain hidden symbols of female anatomy immunogenicity of a monovalent influenza a h n vaccine in infants and children a randomized trial one dose of h n vaccine may provide sufficient protection for infants and children activation of p by nutlin a induces apoptosis and cellular senescence in human glioblastoma multiforme molecule nutlin a activates a signal inducing cell death and senescence in primary brain tumors mesoscopic adaptive resolution scheme toward understanding of interactions between sickle cell fibers computer models provide new understanding of sickle cell disease quantitative assessment of cerebral connectivity deficiency and cognitive impairment in children with prenatal alcohol exposure no safe amount of alcohol during pregnancy suggest researchers adenosine a a receptors in the olfactory bulb suppress rapid eye movement sleep in rodents new role of adenosine in the regulation of rem sleep discovered reconsidering current objectives for physical activity within physical education physical activity within physical education time for a rethink ? maternal perchlorate levels in women with borderline thyroid function during pregnancy and the cognitive development of their offspring data from the controlled antenatal thyroid study common chemical in mothers may negatively affect the iq of their unborn children does targeted cognitive training reduce educational disparities in cognitive function among cognitively normal older adults ? cognitive training effects differ by older adult s education level exploring the genetic architecture of inflammatory bowel disease by whole genome sequencing identifies association at adcy largest genetic study of inflammatory bowel disease provides clues on new drug targets thyroid function within the normal range subclinical hypothyroidism and the risk of atrial fibrillation irregular heartbeat linked to higher thyroid hormone levels cigarette use is increasing among people with illicit substance use disorders in the united states emerging disparities in vulnerable populations cigarette smoking is increasing among americans with drug problems secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor bundles of nerves arteries provide wealth of new stem cell information predictors of inpatient psychiatric hospitalization for children and adolescents with autism spectrum disorder hospitalization risk factors for kids with autism identified brain moderators supporting the relationship between depressive mood and pain multiple brain regions moderate and link depressive mood and pain microrna based strategy to mitigate the risk of gain of function influenza studies scientists develop method that ensures safe research on deadly flu viruses strategy turns molecules in human lung cells into viral scissors that cut h n bird flu and similar bugs into pieces effect of an intervention to improve the cardiovascular health of family members of patients with coronary artery disease a randomized trial program helps at risk family members of patients with heart disease improve their own heart health acceleration of phenological advance and warming with latitude over the past century spring is springing earlier in polar regions than across the rest of earth marked colour divergence in the gliding membranes of a tropical lizard mirrors population differences in the colour of falling leaves christmas colors disguise gliding lizards in the rainforest body mass index and risk of alzheimer disease a mendelian randomization study of individuals alzheimer s disease likely not caused by low body mass index previous adult attention deficit and hyperactivity disorder symptoms and risk of dementia with lewy bodies a case control study adult adhd significantly increases risk of common form of dementia study finds public health failure in the prevention of neural tube defects time to abandon the tolerable upper intake level of folate upper limit for intake of folate is invalid government urged to fortify flour with folic acid detection of crohn s disease comparison of ct and mr enterography without anti peristaltic agents performed on the same day mr enterography as effective as ct in diagnosing crohn s disease reduces radiation exposure study suggests influence of light at night on murine anxiety and depressive like responses light at night linked to symptoms of depression in mice an exome wide sequencing study of lipid response to high fat meal and fenofibrate in caucasians from the goldn cohort what can a tasty milkshake teach us about the genetics of heart disease ? comparison of tripterygium wilfordii hook f with methotrexate in the treatment of active rheumatoid arthritis trifra a randomised controlled clinical trial chinese herbal remedy as good as methotrexate for treating rheumatoid arthritis study finds the chara genome secondary complexity and implications for plant terrestrialization elucidating the chara genome implications for emergence of land plants in paleozoic era improved cognitive function after transcranial light emitting diode treatments in chronic traumatic brain injury two case reports self administered light therapy may improve cognitive function after traumatic brain injury early combination disease modifying antirheumatic drug therapy and tight disease control improve long term radiologic outcome in patients with early rheumatoid arthritis the year results of the finnish rheumatoid arthritis combination therapy trial early and aggressive arthritis treatment recommended based on results of year trial south pole aitken basin ejecta reveal the moon s upper mantle ancient asteroid impact exposes the moon s interior human papillomavirus hpv testing for normal cervical cytology in low risk women aged years by family physicians female doctors twice as likely to screen low risk women for cervical cancer a successful failure missing the mdg target for under five mortality in south africa south africa s child mortality reduction deemed a successful failure issues of cultural diversity in acquired brain injury abi rehabilitation impact of cultural diversity in brain injury research loss of function mutations in tbc d cause cataracts and male infertility in blind sterile mice and warburg micro syndrome in humans new genetic cause of warburg micro syndrome identified temporal variations in the triggering of myocardial infarction by air temperature in augsburg germany climate change heat induced heart attack risk on the rise global regional and national deaths prevalence disability adjusted life years and years lived with disability for chronic obstructive pulmonary disease and asthma a systematic analysis for the global burden of disease study chronic obstructive pulmonary disease caused. million deaths worldwide in dietary obesity reversibly induces synaptic stripping by microglia and impairs hippocampal plasticity high fat diet prompts immune cells to start eating connections between neurons melatonin decreases estrogen receptor binding to estrogen response elements sites on the oct gene in human breast cancer stem cells melatonin boost a key to fighting breast cancer climate environment and early human innovation stable isotope and faunal proxy evidence from archaeological sites ka in the southern cape south africa technological and cultural innovations amongst early humans not sparked by climate change development and validation of a survival staging system incorporating bnp in patients with light chain al amyloidosis new more accessible staging system developed to predict survival for patients with al amyloidosis contribution of smoking related and alcohol related deaths to the gender gap in mortality evidence from european countries smoking accounts for up to percent of gender gap in deaths across europe research finds microrna mir controls a compensatory response to limit neuronal iron accumulation during adult life and aging combating iron in the brain researchers find anti aging micromolecule partner abundance controls mutualism stability and the pace of morphological change over geologic time ant plant symbioses adapting to changes in partner abundance persistence of avian influenza virus h n in feathers detached from bodies of infected domestic ducks avian influenza virus may persist on feathers fallen from domestic ducks magnetic resonance of hydroxyglutarate in idh mutated low grade gliomas new way developed to image brain tumors and predict recurrence antisense oligonucleotides extend survival and reverse decrement in muscle response in als models next generation als drug silences inherited form of the disease in animal models simulation training for forceps assisted vaginal delivery and rates of maternal perineal trauma simulation forceps training reduced severe perineal tearing by nearly percent patient reported hereditary breast and ovarian cancer in a primary care practice few women at high risk for hereditary breast ovarian cancer receive genetic counseling the toll dorsal pathway is required for resistance to viral oral infection in drosophila response to viral infections depends on entry route of virus early mucosal sensing of siv infection by paneth cells induces il production and initiates gut epithelial disruption surprising discovery hiv hides in gut evading eradication community richness of amphibian skin bacteria correlates with bioclimate at the global scale dermal disruption amphibian skin bacteria is more diverse in cold variable environments chloride cotransporters as a molecular mechanism underlying spreading depolarization induced dendritic beading finding about how water gets into neurons provides new treatment targets for deadly brain swelling cobweb weaving spiders produce different attachment discs for locomotion and prey capture one glue two functions spider webs stick to the ground and elevated surfaces differently oldest finch beaked birds reveal parallel ecological radiations in the earliest evolution of passerines earliest known seed eating perching bird discovered in fossil lake wyoming long term il producing epithelial progenitor cells in chronic obstructive lung disease viral infection and specialized lung cells linked to chronic obstructive pulmonary disease exceptionally high levels of lead pollution in the balkans from the early bronze age to the industrial revolution earliest european evidence of lead pollution uncovered in the balkans duf dosage is linearly associated with increasing severity of the three primary symptoms of autism gene family linked to brain evolution implicated in severity of autism symptoms female to male patients have high prevalence of unsatisfactory paps compared to non transgender females implications for cervical cancer screening study shows elevated rates of inadequate pap tests in transgender men dorsal language stream anomalies in an inherited speech disorder new breakthrough in understanding a severe child speech impediment the relative impact of climate change on the extinction risk of tree species in the montane tropical andes climate change just one of many risks to trees in the tropical andes metabolomic analysis of the cerebrospinal fluid reveals changes in phospholipase expression in the cns of siv infected macaques molecular changes in brain fluid give insight into brain damaging disease the ability of a single bmd and fracture history assessment to predict fracture over years in postmenopausal women the study of osteoporotic fractures assessment of bone density and fracture history can predict long term fracture risk effect of tesamorelin on visceral fat and liver fat in hiv infected patients with abdominal fat accumulation growth hormone analog may reduce risk of fatty liver disease in hiv infected patients erythropoietic response and outcomes in kidney disease and type diabetes diabetes poor response to anti anemia drug predicts higher risk of heart disease or death early gestation as the critical time window for changes in the prenatal environment to affect the adult human blood methylome genome wide dna study shows lasting impact of malnutrition in early pregnancy ethanol induced face brain dysmorphology patterns are correlative and exposure stage dependent imaging study sheds new light on alcohol related birth defects the induced earthquakes in harper and sumner counties southern kansas earthquakes follow wastewater disposal patterns in southern kansas psoralea diturnerae and p. vanberkelae psoraleeae fabaceae two new species restricted to the core cape region of south africa citizen scientists discover new plant species in the cape floral kingdom evolutionary and ecological traps for brown bears ursus arctos in human modified landscapes potential explanation for declines in brown bear populations fto genotype is associated with body mass index and waist circumference in mexican young adults genetic risk for obesity found in many mexican young adults genetic and environmental influences on early literacy skills across school grade contexts school quality genetics play role in child s reading ability low level lead exposure and mortality in us adults a population based cohort study historical lead exposure may be linked to premature deaths from cardiovascular disease in adults in united states each year understanding the nature of atmospheric acid processing of mineral dusts in supplying bioavailable phosphorus to the oceans scientists shed light on the climate changing desert dust fertilizing our oceans development of a new humanized mouse model to study acute inflammatory arthritis humanized mice advance study of rheumatoid arthritis human stell cells implanted in mice improve chances of better therapies determinants of base pair substitution patterns revealed by whole genome sequencing of dna mismatch repair defectiveescherichia coli mutation hotspots in dna research could lead to new insights on cancer risks microdystrophin ameliorates muscular dystrophy in the canine model of duchenne muscular dystrophy quantum leap in gene therapy of duchenne muscular dystrophy who should be on the and bills ? preferences based on gender sexism race racism political affiliation and political ideology who should be on the and bills ? how race gender and politics shape public opinion post dinner resistance exercise improves postprandial risk factors more effectively than pre dinner resistance exercise in patients with type diabetes individuals with type diabetes should exercise after dinner marine reserves can mitigate and promote adaptation to climate change marine reserves help mitigate against climate change say scientists selective deletion of astroglial fmrp dysregulates glutamate transporter glt and contributes to fragile x syndrome phenotypes in vivo neuroscience study identifies new trigger mechanism for fragile x syndrome in mice impact of deforestation and climate on the amazon basin s above ground biomass during amazon s recovery from forest losses limited by climate change virulence inhibitors from brazilian peppertree block quorum sensing and abate dermonecrosis in skin infection models brazilian peppertree packs power to knock out antibiotic resistant bacteria integration of cpg free dna induces de novo methylation of cpg islands in pluripotent stem cells novel tool confers targeted stable editing of epigenome in human stem cells association of season of birth with dna methylation and allergic disease dna markers link season of birth allergy risk context dependent glun b selective inhibitors of nmda receptor function are neuroprotective with minimal side effects reviving drugs with anti stroke potential minus side effects does iq predict cardiovascular disease mortality as strongly as established risk factors ? comparison of effect estimates using the west of scotland twenty cohort study low iq among strongest predictors of cardiovascular disease second only to cigarette smoking in large population study humanized mouse model of rasmussen s encephalitis supports the immune mediated hypothesis rare brain disease in children major breakthroughs in rasmussen s encephalitis autonomic nervous system activation mediates the increase in whole body glucose uptake in response to electroacupuncture electroacupuncture may improve regulation of blood sugar in overweight and obese women myc depletion induces a pluripotent dormant state mimicking diapause oncogene controls stem cells in early embryonic development functional investigation of a non coding variant associated with adolescent idiopathic scoliosis in zebrafish elevated expression of the ladybird homeobox gene causes body axis deformation untwist scoliosis by clipping wings of an overactive ladybird obesity weight loss and progression of disability in rheumatoid arthritis obesity may hasten disability in patients with rheumatoid arthritis a seismic transect across west antarctica evidence for mantle thermal anomalies beneath the bentley subglacial trench and the marie byrd land dome hot rock and ice volcanic chain underlies antarctica seven new hypselostomatid species from china including some of the world s smallest land snails gastropoda pulmonata orthurethra tiny record breaking chinese land snails fit almost times into the eye of a needle a skull of the giant bony toothed bird dasornis aves pelagornithidae from the lower eocene of the isle of sheppey mother of a goose ! giant ocean going geese with bony teeth once roamed across se england nurse practitioner organizational climate in primary care settings implications for professional practice workplace climate key factor for effective nurse practitioner professional practice fetal sex and rhd genotyping with digital pcr demonstrates greater sensitivity than real time pcr world first blood test reduces risk increases accuracy in prenatal testing heart functional and structural compendium of cardiosplenic and cardiorenal networks in acute and chronic heart failure pathology linking heart attack damage to the spleen and kidney an integrated study of heart failure shedding light on light benefits of anthropogenic illumination to a nocturnally foraging shorebird ecologists shed new light on effects of light pollution on wildlife the roller coaster flight strategy of bar headed geese conserves energy during himalayan migrations roller coaster geese insights into high altitude bird flight physiology and biomechanics sound physiological knowledge and principles in modeling shrinking of fishes under climate change warmer waters from climate change will leave fish shrinking gasping for air modulation of subsets of cardiac b lymphocytes improves cardiac function after acute injury scientists id source of damaging inflammation after heart attack investigation of the plasma virome from cases of unexplained febrile illness in tanzania from to a comparative analysis between unbiased and vircapseq vert high throughput sequencing approaches unexplained illness in tanzania puts pathogen discovery to the test age at first exposure to football is associated with altered corpus callosum white matter microstructure in former professional football players altered brain development among former nfl players study suggests ahr signaling activation disrupts migration and dendritic growth of olfactory interneurons in the developing mouse how environmental pollutant dioxin alters brain development in mice ultraluminous x ray bursts in two ultracompact companions to nearby elliptical galaxies unexplainable activity in distant stars new class of explosive events ? global trends in infectious diseases at the wildlife livestock interface lack of knowledge on animal disease leaves humans at risk parental ptsd health behaviors and successful aging among offspring of holocaust survivors parental ptsd affects health behavior and aging among offspring of holocaust survivors aerosol mycobacterium tuberculosis infection causes rapid loss of diversity in gut microbiota tb lung infection causes changes in the diversity of gut bacteria in mice behavioural effects of fetal antidepressant exposure in a norwegian cohort of discordant siblings antidepressant use in pregnancy associated with anxiety symptoms in year olds sex specific effects of dhea on bone mineral density and body composition a pooled analysis of four clinical trials sex specific effects of dhea on bone mineral density and body composition molecular determinants of human neutralizing antibodies isolated from a patient infected with zika virus zika antibodies from infected patient thwart infection in mice from fan to fat ? vicarious losing increases unhealthy eating but self affirmation is an effective remedy for disappointed sports fans defeats increase consumption of fat and sugar herbal hormonal dietary supplement possibly associated with prostate cancer progression certain hormonal dietary supplements might promote prostate cancer progression study finds cyclophilin a function in mammary epithelium impacts jak stat signaling morphogenesis differentiation and tumorigenesis in the mammary gland enzyme in milk production identified as target for novel breast cancer drugs clinical and genomic characterization of treatment emergent small cell neuroendocrine prostate cancer a multi institutional prospective study deadly form of advanced prostate cancer is common calls for distinct treatment fetal growth and gestational factors as predictors of schizophrenia in q. deletion syndrome birth factors may predict schizophrenia in genetic subtype of schizophrenia cross sectional study of loss of life expectancy at different ages related to firearm deaths among black and white americans extent of us lives shortened by gun violence twice as great among blacks as whites high frequency of active hcv infection among seropositive cases in west africa and evidence for multiple transmission pathways west africa hepatitis c more prevalent than hiv aids or ebola yet lacks equal attention costs of tuberculosis disease in the eu a systematic analysis and cost calculation new study puts a price on drug resistant tb cases in eu emergency department initiated buprenorphine naloxone treatment for opioid dependence a randomized clinical trial emergency department treatment for opioid addiction better than referrals a ghrelin growth hormone axis drives stress induced vulnerability to enhanced fear ghrelin a stress induced hormone primes the brain for ptsd a new resource for the development of ssr markers millions of loci from a thousand plant transcriptomes millions of loci from a thousand plant transcriptomes expansion of stem cells counteracts age related mammary regression in compound timp timp null mice fountain of youth uncovered in mammary glands of mice by breast cancer researchers self assembly of embryonic and two extra embryonic stem cell types into gastrulating embryo like structures scientists generate key life event in artificial mouse embryo created from stem cells supporting family caregivers to manage pain medication in cancer patients at end of life a feasibility trial nurse led intervention helps carers manage medication and cancer pain use of influenza antiviral agents by ambulatory care clinicians during the influenza season antivirals underprescribed for patients at risk for flu complications study shows functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and crispr cas screening crispr catches out critical cancer changes new drug target for multiple cancers red meat consumption and risk of type diabetes cohorts of u.s. adults and an updated meta analysis red meat linked to increased risk of type diabetes deeply divergent archaic mitochondrial genome provides lower time boundary for african gene flow into neanderthals dna of early neanderthal gives timeline for new modern human related dispersal from africa lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury targeted oxidation blocker prevents secondary damage after traumatic brain injury study suggests risk factors in swedish young men for amyotrophic lateral sclerosis in adulthood low muscle strength identified as early risk factor for als vascular effects of ultrafine particles in persons with type diabetes pinpointing air pollution s effects on the heart connectivity in coastal systems barrier island vegetation influences upland migration in a changing climate new insight into how climate change is transforming virginia s barrier islands monoamine oxidase a inhibitor near infrared dye conjugate reduces prostate tumor growth unlikely pairing an antidepressant plus dye yields tumor targeting tool modification of the nanostructure of lignocellulose cell walls via a non enzymatic lignocellulose deconstruction system in brown rot wood decay fungi fungi that evolved to eat wood offer new biomass conversion tool mapping local and global liquid phase behavior in living cells using photo oligomerizable seeds new tools illuminate mechanisms behind overlooked cellular components critical roles a global fine root ecology database to address below ground challenges in plant ecology fred database gathers root traits to advance understanding of belowground plant ecology safety and efficacy of dalcetrapib on atherosclerotic disease using novel non invasive multimodality imaging dal plaque a randomised clinical trial unique study shows efficacy of imaging technology in evaluating heart drug dalcetrapib the color of safety ingroup associated colors make beer safer team colors on cans change perceptions of alcohol risks study finds androgen deprivation therapy and the risk of dementia in patients with prostate cancer androgen deprivation therapy not associated with increased risk of alzheimer disease phenotypic analysis of multiplex families with common epilepsies largest ever collection of patient data of inherited epilepsy conditions functional variants in the sucrase isomaltase gene associate with increased risk of irritable bowel syndrome new research links genetic defects in carbohydrate digestion to irritable bowel syndrome homozygous boricua tbck mutation causes neurodegeneration and aberrant autophagy biomarker clues to possible therapy found in novel childhood neurogenetic disease effectiveness of probiotic for primary prevention of clostridium difficile infection a single center before after quality improvement intervention at a tertiary care medical center probiotics useful in the fight against clostridium difficile infection aspirin instead of oral anticoagulant prescription in atrial fibrillation patients at risk for stroke aspirin versus blood thinners in atrial fibrillation patients with stroke risk methamphetamine self administration elicits sex related changes in postsynaptic glutamate transmission in the prefrontal cortex new study examines the way estrogen affects methamphetamine addiction frequency of sahelian storm initiation enhanced over mesoscale soil moisture patterns new study of storm generation could improve rainfall prediction in west africa activated regulatory t cells are the major t cell type emigrating from the skin during a cutaneous immune response in mice dermatology watching immune cell movement to and from the skin marine polyunsaturated fatty acid intake and survival after colorectal cancer diagnosis lower risk of bowel cancer death linked to high omega intake after diagnosis crop manuring and intensive land management by europe s first farmers manure used by europe s first farmers years ago reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres what makes us age ? ticking of cellular clock promotes seismic changes in chromatin landscape associated with aging reconciling precariously balanced rocks pbrs with large earthquakes on the san andreas fault system precariously balanced rocks provide clues for unearthing underground fault connections direct conversion of normal and alzheimer s disease human fibroblasts into neuronal cells by small molecules chemical only cell reprogramming transforms human and mouse skin cells into neurons potential climate engineering effectiveness and side effects during a high carbon dioxide emission scenario climate engineering minor potential major risk of side effects ? the effects of written emotional disclosure and coping skills training in rheumatoid arthritis a randomized clinical trial. cognitive behavioral coping skills training has positive effects on rheumatoid arthritis nucleotide resolution mapping of influenza a virus nucleoprotein rna interactions reveals rna features required for replication id ing features of flu virus genome may help target surveillance for pandemic flu very early administration of progesterone for acute traumatic brain injury progesterone offers no significant benefit in traumatic brain injury clinical trial prediction of cardiovascular mortality by estimated cardiorespiratory fitness independent of traditional risk factors the hunt study knowing your fitness number predicts your risk for future ill health years since scott reached the pole a century of learning about the physiological demands of antarctica a century of learning about the physiological demands of antarctica egfrviii antibody conjugated iron oxide nanoparticles for magnetic resonance imaging guided convection enhanced deliver and targeted therapy of glioblastoma iron oxide nanoparticles becoming tools for brain tumor imaging and treatment modeling methane production from beef cattle using linear and nonlinear approaches way to cut cattle methane threat to environment by percent cd a is a marker of a cd t cell hiv reservoir harbouring replication competent proviruses discovery of an hiv reservoir marker new avenue toward eliminating the virus the case for seasonal surface changes at titan s lake district nasa s cassini reveals surprises with titan s lakes nano bio chip sensor platform for examination of oral exfoliative cytology quick nano bio chip checks for oral cancer adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy key bone marrow protein identified as potential new leukemia treatment target adolescent well being in washington state military families adolescent boys among those most affected by washington state parental military deployment study suggests functional imbalance of anterolateral entorhinal cortex and hippocampal dentate ca underlies age related object pattern separation deficits high resolution brain imaging provides clues about memory loss in older adults effective protection induced by a monovalent dna vaccine against dengue virus dv serotype and a bivalent dna vaccine against dv and dv in mice one step closer to a dna vaccine against dengue virus testing the empathizing systemizing theory of sex differences and the extreme male brain theory of autism in half a million people largest ever study of psychological sex differences and autistic traits health insurance is associated with preventive care but not personal health behaviors health insurance increases preventive care not risky behaviors winning at all costs analysis of inflation in nursing homes rating system some nursing homes gaming the system to improve their medicare star ratings effect of a lifestyle intervention program with energy restricted mediterranean diet and exercise on weight loss and cardiovascular risk factors one year results of the predimed plus trial a hypocaloric mediterranean diet and daily exercise maintain weight loss retrospective memories of parental care and health from mid to late life happy childhood memories linked to better health later in life a re interpretation of cell transplantation gfp transfer from donor to host photoreceptors krembil research prompts rethink on established vision recovery theory fibrinogen and amyloid association alters thrombosis and fibrinolysis a possible contributing factor to alzheimer s disease mechanism links abnormal blood clots with alzheimer s disease how climate change beliefs among u.s. teachers do and do not translate to students do teachers climate change beliefs influence students ? d in vitro model of a functional epidermal permeability barrier from human embryonic stem cells and induced pluripotent stem cells skin layer grown from human stem cells could replace animals in drug cosmetics testing no evidence of publication bias in climate change science no publication bias found in climate change research improving parenting in families referred for child maltreatment a randomized controlled trial examining effects of project support. abusive mothers improve parenting after in home training emotional support of therapists pain pain go away improving the vaccination experience at school pain pain go away new tools improve students experience of school based vaccines migratory bats respond to artificial green light with positive phototaxis nathusius and soprano bats are attracted to green light large climate driven changes of oceanic oxygen concentrations during the last deglaciation ice age findings forecast problems data from end of last ice age confirm effects of climate change on oceans lack of microbial diversity in an extreme mars analog setting po s volcano costa rica microbes living in a toxic volcanic lake could hold clues to possible life on mars relative performance of hpv and cytology components of cotesting in cervical screening hpv testing is better than the pap test at detecting cervical cancer obesity in men with childhood adhd a year controlled prospective follow up study link between childhood adhd and obesity revealed in first long term study association of retinopathy of prematurity with low levels of arachidonic acid new discovery offers hope of protecting premature babies from blindness alternate healthy eating index and risk of chronic obstructive pulmonary disease among us women and men prospective study healthy diet linked to lower risk of chronic lung disease probing strigolactone receptors in striga hermonthica with fluorescence green light of hope to overcome striga triggered food insecurity in africa identifying division symmetry of mouse embryonic stem cells negative impact of dna methyltransferases on symmetric self renewal study of sister stem cells uncovers new cancer clue effectiveness of non nucleoside reverse transcriptase inhibitor based antiretroviral therapy in women previously exposed to a single intrapartum dose of nevirapine a multi country prospective cohort study hiv drug resistance lasts about one year in women treated with nevirapine to prevent infant infection study suggests long term video surveillance and automated analyses reveal arousal patterns in groups of hibernating bats hot imagery of wintering bats suggests group behavior for battling white nose syndrome evaluating soil salinity and water management in chaco canyon new mexico salt s secret success in ancient chaco canyon causes of ice age intensification across the mid pleistocene transition decline in atmospheric carbon dioxide key to ancient climate transition association between atrial fibrillation and volumetric mri brain measures framingham offspring study association discovered between atrial fibrillation reduced frontal lobe brain volumes the importance of minority teachers student perceptions of minority versus white teachers students of all races prefer teachers of color finds study sesquinary catenae on the martian satellite phobos from reaccretion of escaping ejecta anomalous grooves on martian moon phobos explained by impacts neurocognitive status in long term survivors of childhood cns malignancies a report from the childhood cancer survivor study brain tumors in childhood leave a lasting mark on cognition life status a decade of sea level rise slowed by climate driven hydrology decade of rising seas slowed by land soaking up extra water fast food restaurants and food stores longitudinal associations with diet in young to middle aged adults the cardia study neighborhood fast food availability related to an individual s fast food consumption pregnancy related conditions and premature coronary heart disease in adult offspring pregnancy complications linked to heightened heart disease risk in young adult offspring extra virgin olive oil ameliorates cognition and neuropathology of the xtg mice role of autophagy extra virgin olive oil preserves memory protects brain against alzheimer s comparison of pediatric motor vehicle collision injury outcomes at level i trauma centers children injured in motor vehicle crashes fare better at level i pediatric trauma centers racial and ethnic disparities in colorectal cancer screening persisted despite expansion of medicare s screening reimbursement racial disparities still exist in colorectal cancer screening despite increased medicare coverage study finds the influence of morphological variation on migration performance in a trans hemispheric migratory songbird how variation in body size correlates with en route migration performance of songbirds caribbean wide decline in carbonate production threatens coral reef growth new evidence highlights threat to caribbean coral reef growth many caribbean coral reefs are starting to erode a possible causative mechanism of raton basin new mexico and colorado earthquakes using recent seismicity patterns and pore pressure modeling raton basin earthquakes linked to oil and gas fluid injections gut bacteria mediate aggregation in the german cockroach pivotal role of gut bacteria in insect to insect communication a map for social navigation in the human brain human brain may contain a map for social navigation the eating disorder associated hdac a t mutation alters feeding behaviors in female mice eating disorder gene alters feeding and behavior in female mice temperature enhanced succinate production concurrent with increased central metabolism turnover in the cyanobacterium synechocystis sp. pcc world s most efficient production of succinate from carbon dioxide unaccounted workload factor game day pitch counts in high school baseball pitchers an observational study for high school baseball pitchers extra throws on game day add up but go uncounted health risk behaviors in teens investigated by u.s. child welfare agencies teens in child welfare system practice similar health risk behaviors as general teen population study finds association of gestational diabetes with maternal disorders of glucose metabolism and childhood adiposity high blood sugar during pregnancy ups risk of mother s type diabetes child s obesity do better in math how your body posture may change stereotype threat response math with good posture can mean better scores study suggests ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response implication for traffic related asthma flares ultrafine particles in air pollution may heighten allergic inflammation in asthma puerto rico and florida manatees represent genetically distinct groups isolation of puerto rico s manatees affects survival odds ancient goat genomes reveal mosaic domestication in the fertile crescent ancient genome analyses reveal mosaic pattern of goat domestication thousands of years ago a randomized add on trial of an n methyl d aspartate antagonist in treatment resistant bipolar depression ketamine may relieve depression quickly for those with treatment resistant bipolar disorder preservation of general intelligence following traumatic brain injury contributions of the met brain derived neurotrophic factor one gene influences recovery from traumatic brain injury diffusion defining atomic scale spinodal decomposition within nanoprecipitates optimization of alloy materials diffusion processes in nano particles decoded preliminary x ray ct investigation to link hounsfield unit measurements with the international system of units si new x ray measurement approach could improve ct scanners topical interleukin receptor antagonist for treatment of dry eye diseasea randomized clinical trial topical use of arthritis drug provides relief for dry eye disease study suggests dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease the nose knows in asthma nasal tissue samples may advance personalized medicine for asthma a randomized trial of increasing patching for amblyopia extended daily eye patching effective at treating stubborn amblyopia in children a new apameine genus and species from the southern appalachian mountains usa lepidoptera noctuidae noctuinae a new species of moth from the appalachian mountains named to honor the cherokee nation ppar agonist rosiglitazone reverses perinatal nicotine exposure induced asthma in rat offspring hope for reversing childhood asthma associated with maternal smoking bullying and sexual abuse and their association with harmful behaviours antidepressant use and health related quality of life in adulthood a population based study in south australia binge eating and smoking linked to bullying and sexual abuse rhesus monkeys show human like changes in gaze following across the lifespan do you see what i see ? study shows development of gaze following in monkeys is similar to humans better patient care at high quality hospitals may save medicare money and bolster episode based payment models surgery at high quality hospitals costs medicare less than at low quality hospitals assessing website password practices over a decade of progress ? decade of research shows little improvement in websites password guidance human blood vessel organoids as a model of diabetic vasculopathy scientists grow perfect human blood vessels in a petri dish grader variability and the importance of reference standards for evaluating machine learning models for diabetic retinopathy google s ai program building better algorithms for detecting eye disease is this my finger ? proprioceptive illusions of body ownership and representation is this my finger ? sensory illusion study provides new insight for body representation brain disorders total red meat intake of. servings d does not negatively influence cardiovascular disease risk factors a systemically searched meta analysis of randomized controlled trials nutrition data review shows red meat has neutral effect on cardiovascular disease risk factors male specific tachykinin expressing neurons control sex differences in levels of aggressiveness in drosophila fighting flies brain cells promote fighting in male fruit flies long term outcomes of early intervention in year old children with autism spectrum disorder early intervention improves long term outcomes for children with autism the role of trauma and stressful life events among individuals at clinical high risk for psychosis a review assessing and addressing the impact of childhood trauma the role of facial pattern variation for species recognition in red fronted lemurs eulemur rufifrons facial attraction red fronted lemurs recognize photos of their own species preliminary evaluation of serum total cholesterol concentrations in dogs with osteosarcoma elevated cholesterol s link with canine cancer includes a better prognosis estimation of global recoverable human and animal faecal biomass growing pile of human and animal waste harbors threats opportunities effective secondary fracture prevention implementation of a global benchmarking of clinical quality using the iof capture the fracture best practice framework tool best practice framework is good benchmarking tool for fracture liaison services worldwide targeting metabolic reprogramming by influenza infection for therapeutic intervention new strategy reported to combat influenza and speed recovery survival and outcomes following bioprosthetic vs mechanical mitral valve replacement in patients aged to years no long term survival difference found between types of mitral valve replacements formation of nitrogen doped graphene nanoscrolls by adsorption of magnetic fe o nanoparticles graphene nanoscrolls are formed by decoration of magnetic nanoparticles small molecule wnt agonists correct cleft palates in pax mutant mice in utero in utero treatment reverses cleft palate in mice neoadjuvant radiotherapy of early stage breast cancer and long term disease free survival radiation prior to surgery reduces risk of secondary tumors in early stage breast cancer life history traits of lepetodrilus nux in the okinawa trough based upon gametogenesis shell size and genetic variability delving into the spread of marine life understanding deep sea limpets longitudinal rna seq analysis of vertebrate aging identifies mitochondrial complex i as a small molecule sensitive modifier of lifespan short lived killifish reveals link between gene expression longevity landowner behavior can determine the success of conservation strategies for ecosystem migration under sea level rise some land conservation measures unpopular among property owners efficacy of an internet based learning module and small group debriefing on trainees attitudes and communication skills toward patients with substance use disorders online intervention tool for physician trainees may improve care of patients with substance use disorders horses working in therapeutic riding programs cortisol adrenocorticotropic hormone glucose and behavior stress indicators horses working in therapeutic riding programs do not experience additional stress eocene metatherians from anatolia illuminate the assembly of an island fauna during deep time deep time evolution of animal life on islands optimal seismic network density for earthquake early warning a case study from california improving earthquake early warning systems for california and taiwan madagascar can build stronger health systems to fight plague and prevent the next epidemic building stronger health systems could help prevent the next epidemic in madagascar association of genetic variants related to serum calcium levels with coronary artery disease and myocardial infarction genetic predisposition to higher calcium levels linked with increased risk of coronary artery disease tau platelets correlate with regional brain atrophy in patients with alzheimer s disease promising discovery for a non invasive early detection of alzheimer s disease prostate cancer risk in men with baseline history of coronary artery disease results from the reduce study heart disease may be a risk factor for prostate cancer gpi defines self renewal ability in hematopoietic stem cells during human development unique protein found key to development of blood stem cells direct detection of tissue resident bacteria and chronic inflammation in the bladder wall of postmenopausal women with recurrent urinary tract infection bacteria s role in recurrent urinary tract infections brain organization underlying superior mathematical abilities in children with autism autistic kids who best peers at math show different brain organization anomalous contagion and renormalization in networks with nodal mobility contagion in popular places from zika to political extremism feasible future global scenarios for human life evaluations future changes in human well being to depend more on social factors than economic factors the heart of the matter on breastmilk and environmental chemicals essential points for health care providers and new parents benefits of breastfeeding outweigh risk of infant exposure to environmental chemicals in breastmilk recurrent urinary tract infections among women comparative effectiveness of prevention and management strategies using a markov chain monte carlo model daily antibiotics most effective in preventing recurrent urinary tract infection experimental inhibition of porcupine mediated wnt o acylation attenuates kidney fibrosis wnt secretion preventing drugs may reduce renal fibrosis study shows anti thymocyte globulin for conditioning in matched unrelated donor hematopoietic cell transplantation provides comparable outcomes to matched related donor recipients antibodies from rabbits improve survival of leukemia and myelodysplasia patients receiving stem cell transplant toxicdocs www.toxicdocs.org from history buried in stacks of paper to open searchable archives online free online access to millions of documents on chemical toxicity made possible through toxicdocs ganglioside gd is required for neurogenesis and long term maintenance of neural stem cells in the postnatal mouse brain biological fat with a sugar attached essential to maintaining brain s supply of stem cells asymmetric european summer heat predictability from wet and dry southern winters and springs more summer heatwaves likely in europe predictability of european summer heat from spring and winter rainfall imaging the cytokine receptor cxcr in atherosclerotic plaques with the radiotracer ga pentixafor for pet new pet radiotracer identifies inflammation in life threatening atherosclerosis maternal intake of sugar during pregnancy and childhood respiratory and atopic outcomes sugar intake during pregnancy is associated with allergy and allergic asthma in children the visual system in infants with microcephaly related to presumed congenital zika syndrome infants with congenital zika virus syndrome suffer serious visual impairment gene therapy for adenosine deaminase deficient severe combined immune deficiency clinical comparison of retroviral vectors and treatment plans stem cell researchers use gene therapy to restore immune systems in bubble boy disease predicted year risk of developing cardiovascular disease at the state level in the u.s. new state level data demonstrate geographical variation in year cardiovascular risk pharmacokinetics of long acting tenofovir alafenamide gs subdermal implant for hiv prophylaxis stopping hiv in its tracks new subdermal implant delivers potent antiretroviral drugs friends status symbols and weapons the use of dogs by youth groups and youth gangs youths in tough gangs own dogs for companionship and socializing examination of cumulative effects of early adolescent depression on cannabis and alcohol use disorder in late adolescence in a community based cohort depression among young teens linked to cannabis use at kochia kochia scoparia emergence profiles and seed persistence across the central great plains importance of early season control of herbicide resistant kochia a year experience of hepatic resection for melanoma is there an expanding role ? surgical treatment for metastatic melanoma of the liver increases overall survival disease mongering of age associated declines in testosterone and growth hormone levels marketing prescribing testosterone and growth hormone for aging is disease mongering experts say hcn rescues brain defects by enforcing endogenous voltage pre patterns researchers rescue embryos from brain defects by re engineering cellular voltage patterns association of autoimmune type atrophic corpus gastritis with helicobacter pylori infection etiological role for h. pylori in autoimmune gastritis medical financial hardship among cancer survivors in the united states cancer survivors face significant hardships related to medical bills population health impact and cost effectiveness of tuberculosis diagnosis with xpert mtb rif a dynamic simulation and economic evaluation new test for tuberculosis could improve treatment prevent deaths in southern africa longitudinal trends in resource use in an incident cohort of open angle glaucoma patients resource use in open angle glaucoma the cost of glaucoma care small group of patients accounts for large part of costs seismic evidence for partial melting at the root of major hot spot plumes getting to the root of iceland s molten rock origins biomechanical strain exacerbates inflammation on a progeria on a chip model organ on a chip model offers insights into premature aging vascular disease the electronic trauma health record design and usability of a novel tablet based tool for trauma care and injury surveillance in low resource settings trauma center launches portable electronic trauma health record application insulin resistance is associated with poorer verbal fluency performance in women study links insulin resistance with language problems in women two fungal symbioses collide endophytic fungi are not welcome in leaf cutting ant gardens food security for leaf cutting ants workers and their fungus garden reject invaders lin enhances tissue repair by reprogramming cellular metabolism researchers regrow hair cartilage bone soft tissues enhancing cell metabolism key to tissue repair increased land subsidence and sea level rise are submerging egypt s nile delta coastal margin looming crisis of the much decreased fresh water supply to egypt s nile delta reversing nerve cell pathology by optimizing modulatory action on target ion channels optimal modulation of ion channels rescues neurons associated with epilepsy graduated driver licensing and fatal crashes involving to year old drivers stronger graduated driver licensing programs for teens show mixed results for rates of teen involvement in fatal crashes the african turquoise killifish genome provides insights into evolution and genetic architecture of lifespan killifish project explores the genetic foundation of longevity gaps in referral to cardiac rehabilitation of patients undergoing percutaneous coronary intervention in the united states institutional factors play role in cardiac rehab referral rates after angioplasty good quality locally procured drugs can be as effective as internationally quality assured drugs in treating multi drug resistant tuberculosis locally sourced drugs can be effective for treating multidrug resistant tb combining migration and wintering counts to enhance understanding of population change in a generalist raptor species the north american red tailed hawk combined count data reveals shifts in hawks migratory behavior association between lymph node evaluation for colon cancer and node positivity over the past years large increase seen in number of lymph nodes evaluated for colon cancer but no corresponding rise in node positive cancers the cost effectiveness of rapid hiv testing in substance abuse treatment results of a randomized trial cost effectiveness of hiv testing in drug abuse treatment programs demonstrated effect of a school based water intervention on child body mass index and obesity water dispensers in nyc public schools associated with student weight loss musical experience and the aging auditory system implications for cognitive abilities and hearing speech in noise musical experience offsets some aging effects older musicians excel in memory and hearing speech in noise compared to non musicians late cenozoic cooling favored glacial over tectonic controls on sediment supply to the western gulf of mexico ice age climate caused sediment sourcing in gulf of mexico to switch dramatically maternal singing during kangaroo care led to autonomic stability in preterm infants and reduced maternal anxiety maternal singing during skin to skin contact benefits both preterm infants mothers the cryo em structure of a novel s kinetoplastid specific ribosomal protein discovery of a potential therapeutic target to combat trypanosomes isolation of circulating plasma cells from blood of patients diagnosed with clonal plasma cell disorders using cell selection microfluidics chip based blood test for multiple myeloma could make bone biopsies a relic of the past prenatal exposure to alcohol causes enduring brain damage prenatal alcohol exposure services insufficient in supporting those affected the discovery of potent selective and reversible inhibitors of the house dust mite peptidase allergen der p an innovative approach to the treatment of allergic asthma novel approach to treating asthma neutralize the trigger bayesian estimates of male and female african lion mortality for future use in population management high death rates from unnatural causes for male lions in cecil the lion s park elevated eosinophil protein x in urine from healthy neonates precedes development of atopy in the first years of life researchers identify early biomarker for future atopy in asymptomatic children ezh methyltransferase activity controls pten expression and mtor signaling during fear memory reconsolidation novel epigenetic control found for critical brain proteins in memory strengthening early evidence of low bone density and decreased serotonergic synthesis in the dorsal raphe of a tauopathy model of alzheimer s disease link between brain bone in alzheimer s disease identified spin orbit torques in co pd multilayer nanowires new innovation enhances information storage in electronic ushers in new era of computing clinical case series treatment of ptsd with transcendental meditation in active duty military personnel transcendental meditation may reduce ptsd symptoms medication use in active duty personnel conserved role of ovo in germline development in mouse and drosophila conserved role for ovo protein in reproductive cell development in mice and fruit flies ontogeny and taxonomy of the hadrosaur dinosauria ornithopoda remains from basturs poble bonebed late early maastrichtian tremp syncline spain most complete study on europe s greatest hadrosaur site published swimming induced pulmonary oedema in two triathletes a novel pathophysiological explanation endurance athletes at risk of swimming induced pulmonary oedema replication stress caused by low mcm expression limits fetal erythropoiesis and hematopoietic stem cell functionality new avenue for combating deterioration in blood stem cells correlating the ancient maya and modern european calendars with high precision ams c dating maya long count calendar calibrated to modern european calendar using carbon dating young children spontaneously invent wild great apes tool use behaviours human children and wild great apes share their tool use cognition he value of daily platelet counts for predicting dengue shock syndrome results from a prospective observational study of vietnamese children with dengue blood test predicts kids at risk for dengue shock syndrome the rise of jaw protrusion in spiny rayed fishes closes the gap on elusive prey a long look back at fishes extendable jaws worker reproduction of the invasive yellow crazy ant anoplolepis gracilipes yellow crazy ant workers lay eggs as a food source malignant cells facilitate lung metastasis by bringing their own soil tumors bring their own support cells when forming metastases noncancerous cells from primary site appear to facilitate tumor growth expression of genes involved in vascular morphogenesis and maturation predicts efficacy of bevacizumab based chemotherapy in patients undergoing liver resection new biomarker allows better prediction of survival for patients with colorectal metastases residual inequity assessing the unintended consequences of new york city s clean heat transition use of dirty heating oil in new york city concentrated uptown a molecular portrait of maternal sepsis from byzantine troy byzantine skeleton yields year old genomes from a fatal infection wading a lost southern connection miocene fossils from new zealand reveal a new lineage of shorebirds charadriiformes linking gondwanan avifaunas new species find in central otago confirms link between australian and south american shorebirds minimally invasive synthetic suburethral sling operations for stress urinary incontinence in women stress urinary incontinence minimally invasive operations as effective as open surgery a financial market model with two discontinuities bifurcation structures in the chaotic domain the price of chaos a new model virtually pits new investors against experienced ones muskie lunacy does the lunar cycle influence angler catch of muskellunge esox masquinongy ? large muskies lured by the moon study ties lunar cycles fish behavior to angler success recovery focused cognitive behavioural therapy for recent onset bipolar disorder randomised controlled pilot trial talking therapy for people with a recent bipolar disorder diagnosis transcatheter or surgical aortic valve replacement in intermediate risk patients major global study identifies a safer treatment of acute stroke water management adaptations to prevent loss of spring run chinook salmon in california under climate change warming streams could be the end for spring run chinook salmon in california mortality in north american dogs from to an investigation into age size and breed related causes of death breed specific causes of death in dogs revealed in landmark study neutrino interferometry for high precision tests of lorentz symmetry with icecube study of high energy neutrinos again proves einstein right identification of diverse mycoviruses through metatranscriptomics characterization of the viromes of five major fungal plant pathogens potential biological control agents found for fungal diseases of soybean common core writing and language standards and aligned state assessments a national survey of teacher beliefs and attitudes teachers optimistic about common core writing standards but not tests ice plug prevents irreversible discharge from east antarctica uncontrollable ice melt ? uncorking east antarctica could yield unstoppable sea level rise simulations show acupuncture for chronic painindividual patient data meta analysis acupuncture may be better than no acupuncture sham acupuncture for chronic pain sheathless inertial cell focusing and sorting with serial reverse wavy channel structures flowing cells in a wavy microchannel for effective size based cell sorting association of back pain with all cause and cause specific mortality among older women a cohort study back pain shows significant association with mortality among older women leveraging single cell genomics to expand the fungal tree of life expanding fungal diversity one cell at a time site specific recombinases from tag and target to tag and exchange based genomic modifications the newest of the new in gene therapy tag and target and exchange international committee for monitoring assisted reproductive technologies world report on assisted reproductive technologies world report on fertility treatments reveals high use of intracytoplasmic sperm injection factors associated with pediatric mortality from motor vehicle crashes in the united states a state based analysis new study examines child death rates in motor vehicle crashes by state early protection to stress mediated by cdk dependent pi p signaling from the vacuole lysosome newly identified protection mechanism serves as first responder to cellular stress natural killer cells eradicate galectin deficient glioma in the absence of adaptive immunity brain tumors fly under body s radar like stealth jets new research suggests long term disease dynamics for a specialized parasite of ant societies a field study zombie ant fungi manipulate hosts to die on the doorstep of the colony a pilot controlled trial of insulin like growth factor in children with phelan mcdermid syndrome growth hormone treatment improves social impairments in patients with genetic disorder known to cause autism annual radiocarbon record indicates th century bce date for the thera eruption dating the ancient minoan eruption of thera using tree rings stem cell transplantation reverses chemotherapy induced cognitive dysfunction human neural stem cells restore cognitive functions impaired by chemotherapy toxin producing clostridium difficile strains as long term gut colonizers of healthy infants toxigenic c. difficile resides harmlessly in infants poses risk to adults discovery of scattering polarization in the hydrogen ly line of the solar disk radiation first direct exploration of magnetic fields in the upper solar atmosphere genome wide association study identifies nox as a critical gene for susceptibility to noise induced hearing loss genetic predisposition found for noise induced hearing loss early anthropogenic transformation of the danube black sea system human impact felt on black sea long before industrial era evaluation of a high efficiency cabin air heca filtration system for reducing particulate pollutants inside school buses on board school bus filtration system reduces pollutants by percent engineering strategies to decode and enhance the genomes of coral symbionts a super algae to save our seas ? genetic engineering species to save corals optimization of affinity specificity and function of designed influenza inhibitors using deep sequencing computer designed proteins programmed to disarm variety of flu viruses improving survival by exploiting tumour dependence on stabilized mutant p for treatment removing mutant p significantly regresses tumors improves cancer survival antitumor activity of a potent mek inhibitor tak against colorectal cancer cell lines and patient derived xenografts tak shows challenge of using a promising drug in the human body early episodes of high pressure core formation preserved in plume mantle earth s core and mantle separated in a disorderly fashion immediate effects of tdcs on the opioid system of a chronic pain patient electric stimulation of brain releases powerful opiate like painkiller learning historical thinking with oral history interviews a cluster randomized controlled intervention study of oral history interviews in history lessons oral history in history lessons more fun less learned cyclin d induction of dicer governs microrna processing and expression in breast cancer protien cyclin d governs microrna processing in breast cancer family interactions and disordered eating attitudes the mediating roles of social competence and psychological distress over bearing mothers can produce daughters with poor social skills and disordered eating attitudes mutations in cnnm cause jalili syndrome consisting of autosomal recessive cone rod dystrophy and amelogenesis imperfect gaza strip families give first clue to condition causing blindness and tooth decay longevity is impacted by growth hormone action during early postnatal period hormonal changes during early development limit lifespan in mice proteomic landscape of the human choroid retinal pigment epithelial complex a map for eye disease most detailed molecular map of eye region associated with vision loss no increase in autism associated genetic events in children conceived by assisted reproduction potential link between assisted reproduction autism no link found maternal low protein diet up regulates the neuropeptide y system in visceral fat and leads to abdominal obesity and glucose intolerance in a sex and time specific manner stress during pregnancy leads to abdominal obesity in mice offspring short term and long term safety of weekly high dose vitamin d supplementation in school children current vitamin d recommendations fraction of safe perhaps essential levels for children three postpartum antiretroviral regimens to prevent intrapartum hiv infection drug combo can block mother to infant hiv transmission study suggests expert judgement and uncertainty quantification for climate change new tool puts a consistent value on experts uncertainty on climate change models high mobility field effect transistors with versatile processing from a small molecule organic semiconductor high performance semiconductor spray paint could be a game changer for organic electronics cdk inhibitors target smarca determined cyclin d deficiency in hypercalcemic small cell carcinoma of the ovary shared genetic marker offers new promise in targeting specific ovarian and lung cancers economic burden of inadequate management of allergic diseases in the european union a ga len review inadequately managed allergies cause significant economic burden in europe conversion of deoxynivalenol to acetyldeoxynivalenol in barley derived fuel ethanol co products with yeast expressing trichothecene o acetyltransferases research offers means to detoxify mycotoxin contaminated grain intended for ethanol animal feed aquatic risks from human pharmaceuticals modelling temporal trends of carbamazepine and ciprofloxacin at the global scale pharmaceutical residues in fresh water pose a growing environmental risk mechanisms of myocardial infarction in women without angiographically obstructive coronary artery disease new hidden heart attack culprit identified in women apoptosis propagates through the cytoplasm as trigger waves in apoptosis cell death spreads through perpetuating waves burden of cardiovascular risk factors and cardiovascular disease in childhood cancer survivors data from the german cvss study survivors of childhood cancer are at great risk of heart problems in adulthood frequency of infant stroking reported by mothers moderates the effect of prenatal depression on infant behavioural and physiological outcomes mother s touch could change effects of prenatal stress a novel quantitative assessment of whole blood thrombogenicity in patients treated with a non vitamin k oral anticoagulant finding the right antithrombotic anti clotting drug for you prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of friedreich s ataxia friedreich s ataxia effective gene therapy in animal model adipose tissue is a neglected viral reservoir and an inflammatory site during chronic hiv and siv infection a potential role for fat tissue as an hiv reservoir and source of chronic inflammation a long term decrease in the persistence of soil carbon caused by ancient maya land use carbon reserves in central american soils still affected by ancient mayan deforestation risk of fever after pediatric trivalent inactivated influenza vaccine and valent pneumococcal conjugate vaccine brief fever common in kids given influenza pneumococcal vaccines together the survival benefits of antiretroviral therapy in south africa study highlights massive benefits of hiv treatment in south africa human gain of function mc r variants show signaling bias and protect against obesity genetic variants that protect against obesity could aid new weight loss medicines impaired cognitive functioning in cochlear implant recipients over the age of years a cross sectional study using the repeatable battery for the assessment of neuropsychological status for hearing impaired individuals rbans h older adults fitted with cochlear implants exhibit poor brain function adjuvant chemotherapy is associated with improved survival in patients with stage ii colon cancer adjuvant chemotherapy in early stage colon cancer may improve survival is cooking at home associated with better diet quality or weight loss intention ? home cooking a main ingredient in healthier diet study shows increasing mobility of high arctic sea ice increases marine hazards off the east coast of newfoundland arctic sea ice becoming a spring hazard for north atlantic ships training in compensatory strategies enhances rapport in interactions involving people with m bius syndrome rare facial paralysis gives researchers new insights into social interaction untangling the association between migraine pain and anxiety examining migraine and generalized anxiety disorders in a canadian population based study adults with migraines have triple the prevalence of generalized anxiety disorder whole genome sequencing identifies genomic heterogeneity at a nucleotide and chromosomal level in bladder cancer two separate molecular profiles of invasive bladder cancer genomic analysis reveals infant hospitalizations for pertussis before and after tdap recommendations for adolescents infant pertussis hospitalizations lower than expected after teen vaccinations teeth sex and testosterone aging in the world s smallest primate teeth sex and testosterone reveal secrets of aging in wild mouse lemurs safe storage of opioid pain relievers among adults living in households with children majority of opioid medications not safely stored in homes with children survey finds activation of cdk triggers development of non alcoholic fatty liver disease study finds potential treatment for non alcoholic fatty liver disease health monitors for chronic disease by gait analysis with mobile phones gaittrack app makes cellphone a medical monitor for heart lung patients nocturnal light emitting diode induced fluorescence ledif a new technique to measure the chlorophyll a fluorescence emission spectral distribution of plant canopies in situ a late night disco in the forest reveals tree performance chronic alcohol remodels prefrontal neurons and disrupts nmdar mediated fear extinction encoding heavy drinking rewires brain increasing susceptibility to anxiety problems the present induced earthquake sequence in the raton basin of northern new mexico and southern colorado wastewater injection is culprit for most earthquakes in southern colorado and northern new mexico study finds disease model discovery from gene knockouts by the international mouse phenotyping consortium characterizing the mouse genome reveals new gene functions and their role in human disease parental psychiatric disease and risks of attempted suicide and violent criminal offending in offspring parents psychiatric disease linked to kids risk of suicide attempt violent offending road traffic accidents but not other physically traumatic events predict the onset of chronic widespread pain results from the epifund study traffic accidents linked to increased risk of chronic widespread pain extreme genomic erosion after recurrent demographic bottlenecks in the highly endangered iberian lynx scientists sequence the genome of the iberian lynx the most endangered feline cholesterol hydroxylase defect is implicated in memory impairments associated with alzheimer like tau pathology modulation of brain cholesterol new line of research in alzheimer s disease treatment ? oral contraceptive use and estrogen progesterone receptor u negative breast cancer among african american women oral contraceptive use associated with increased risk of breast cancer in african american women study finds markers of bone resorption and formation during abstinence in male alcoholic patients abstinence from alcohol plus physical exercise can help reclaim bone loss due to alcoholism loss of equilibrative nucleoside transporter ent in mice leads to progressive ectopic mineralization of spinal tissues resembling diffuse idiopathic skeletal hyperostosis dish in humans arthritis research mouse model of diffuse idiopathic skeletal hyperostosis discovered trait anxiety mediates the link between inferior frontal cortex volume and negative affective bias in healthy adults brain structure anxiety and negative bias linked in healthy adults pharmaceutical jewelry earring patch for transdermal delivery of contraceptive hormone contraceptive jewelry could offer a new family planning approach a review of susbstance use disorder treatment in developing world communities global public health objectives need to address substance abuse in developing countries assessment of levels of ultraviolet a light protection in automobile windshields and side windows study finds low levels of ultraviolet a light protection in automobile side windows ligo gravitational wave detection primordial black holes and the near ir cosmic infrared background anisotropies scientist suggests possible link between primordial black holes and dark matter decoding subjective preference from single trial near infrared spectroscopy signals scientists read minds with infrared scan optical brain imaging decodes preference with percent accuracy programmed cell death ligand expression is upregulated in the skeletal muscle of patients with myasthenia gravis immune checkpoints could be key to treating autoimmune disease myasthenia gravis analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid trpv expressing neurons the hitch in the drug ? the itch in the drug scientists discover clue to ending chronic itching side effect of certain drugs dark chocolate supplementation reduces the oxygen cost of moderate intensity cycling eating dark chocolate as a daily snack could help boost athletic performance genomic estimation of complex traits reveals ancient maize adaptation to temperate north america farmers selected maize for agricultural use at high elevations bring the outside in providing accessible experiences through vr for people with dementia in locked psychiatric hospitals vr can improve quality of life for people with dementia species specific developmental timing is maintained by pluripotent stem cells ex utero stem cells fiercely abide by innate developmental timing study shows climate model shows large scale wind and solar farms in the sahara increase rain and vegetation large wind and solar farms in the sahara would increase heat rain vegetation can payment per click induce improvements in click fraud identification technologies ? pay per click advertising lacks controls against fraud study finds cassini finds molecular hydrogen in the enceladus plume evidence for hydrothermal processes new insights into ocean worlds in our solar system zika virus infection as a cause of congenital brain abnormalities and guillain barr syndrome systematic review how we know zika virus causes guillain barre syndrome and birth defects metabolic interplay between the asian citrus psyllid and its profftella symbiont an achilles heel of the citrus greening insect vector good and bad bacteria in the fight against citrus greening disease increasing arousal enhances inhibitory control in calm but not excitable dogs stress sweet spot differs for mellow vs. hyper dogs ultrafast quantum path interferometry revealing the generation process of coherent phonons a light matter understanding the raman dance of solids modeling marine surface microplastic transport to assess optimal removal locations to clean up ocean plastics focus on coasts not the great pacific garbage patch graphene layer encapsulation of non noble metal nanoparticles as acid stable hydrogen evolution catalysts finding the right balance for catalysts in the hydrogen evolution reaction vocal performance affects metabolic rate in dolphins implications for animals communicating in noisy environments dolphins use extra energy to communicate in noisy waters dominant integration locus drives continuous diversification of plant immune receptors with exogenous domain fusions plants share defensive proteins in evolutionary pick n mix radiation with or without antiandrogen therapy in recurrent prostate cancer new treatment regimen extends life for some men with recurrent prostate cancer study finds were james bond s drinks shaken because of alcohol induced tremor ? james bond s preference for shaken martinis may be due to alcohol induced tremor analgesic effect of manual acupuncture and laser acupuncture for lateral epicondylalgia a systematic review and meta analysis comparing analgesic effect of manual vs laser acupuncture for lateral epicondylalgia erlotinib resistance in mouse models of epidermal growth factor receptor induced lung adenocarcinoma new mouse could help understand how some lung cancer cells evade drug treatment exposure to indoor tanning without burning and melanoma risk by sunburn history indoor tanning even without burning increases the risk of melanoma nanomanufacturing of silicon surface with a single atomic layer precision via mechanochemical reactions a simple method etches patterns at the atomic scale folate concentrations in pediatric patients with newly diagnosed inflammatory bowel disease children with inflammatory bowel disease have surprisingly high folate levels study finds in situ detection of boron by chemcam on mars discovery of boron on mars adds to evidence for habitability the significance of shared leaf shape inalseuosmia pusillaandpseudowintera colorata new research uses novel approach to study plant mimicry a murine model to study epilepsy and sudep induced by malaria infection research team develops first of a kind model to research post malaria epilepsy translocator protein peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis testosterone production study challenges year old scientific dogma american gastroenterological association institute guideline on the diagnosis and management of lynch syndrome aga recommends all patients with colorectal cancer get tested for lynch syndrome ampk modulates tissue and organismal aging in a non cell autonomous manner biologists delay the aging process by remote control optical control of insulin release using a photoswitchable sulfonylurea light activated drug could reduce side effects of diabetes medication lymphatic and angiogenic candidate genes predict the development of secondary lymphedema following breast cancer surgery genetic markers linked to the development of lymphedema in breast cancer survivors life extension factor klotho prevents mortality and enhances cognition in happ transgenic mice protein linked to longevity and enhanced cognition protects against alzheimer s symptoms in mice rare copy number variation discovery and cross disorder comparisons identify risk genes for adhd study finds new adhd genes links susceptibility with autism and other neuropsychiatric conditions impact of biodiversity loss on production in complex marine food webs mitigated by prey release wild fish ecosystems resist impact of biodiversity loss may be masking serious rapid decline in fish production potential gata regulates the self renewal of long term hematopoietic stem cells novel way gene controls stem cell self renewal importance of employee vaccination against influenza in preventing cases in long term care facilities flu vaccines for nursing home workers effective in reducing outbreaks study finds a novel blood feeding detoxification pathway in nippostrongylus brasiliensis l reveals a potential checkpoint for arresting hookworm development scientists identify potential drug target in blood feeding hookworms calculation of voltages in electric power transmission lines during historic geomagnetic storms an investigation using realistic earth impedances new d measurements improve understanding of geomagnetic storm hazards a new species of leopard frog anura ranidae from the urban northeastern us hiding in plain sight a new frog species with a weird croak is identified in new york city lens regeneration using endogenous stem cells with gain of visual function vision restored in rabbits following stem cell transplantation accuracy and bias in perception of distress level and distress change among same sex college student roommate dyads college roommates underestimate each other s distress new psychology research shows adherence to dietary guidelines for americans is associated with a reduced progression of coronary artery atherosclerosis in women with established coronary artery disease following the dietary guidelines may slow heart disease in women intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders new treatment for social problems in autism ? oxytocin improves emotion recognition deep tissue oxygen monitoring in the brain of rabbits for stroke research groundbreaking technique developed to measure oxygen in deep sited tumor brain short chain fatty acids from periodontal pathogens suppress hdacs ezh and suv h to promote kaposi s sarcoma associated herpesvirus replication byproducts of bacteria causing gum disease incite oral cancer growth study shows postnatal effects of intrauterine treatment of the growth restricted ovine fetus with intra amniotic insulin like growth factor alleviating complications of babies born smaller is a growth factor injection the answer ? joint effects of obesity and body height on the risk of venous thromboembolism the troms study being tall obese may significantly increase risk of blood clots in deep veins impact of the dsm attention deficit hyperactivity disorder age of onset criterion in the us adolescent population validity of change in dsm attention deficit hyperactivity disorder adhd age of onset criterion confirmed primary fatty amides in plasma associated with brain amyloid burden hippocampal volume and memory in the european medical information framework for alzheimer s disease biomarker discovery cohort could sleep molecules lead to a blood test for alzheimer s disease ? a synthetic sandalwood odorant induces wound healing processes in human keratinocytes via the olfactory receptor or at olfactory receptors in the skin sandalwood scent facilitates wound healing skin regeneration expansive microbial metabolic versatility and biodiversity in dynamic guaymas basin hydrothermal sediments newly discovered deep sea microbes gobble greenhouse gases and perhaps oil spills too dietary omega fatty acid and fish intake in the primary prevention of age related macular degeneration a systematic review and meta analysis eating fish and foods with omega fatty acids linked to lower risk of age related eye disease application of re insurance models to estimate increases in flood risk due to climate change cost of flood losses in maritimes could increase by up to percent heart failure related hyperphosphorylation in the cardiac troponin i c terminus has divergent effects on cardiac function in vivo mouse studies shed light on how protein controls heart failure epidemiology of imaging detected bone stress injuries in athletes participating in the rio de janeiro summer olympics studies reveal characteristics of bone tendon injuries incurred by olympic athletes viral small t oncoproteins transform cells by alleviating hippo pathway mediated inhibition of the yap proto oncogene birthdate matters for wiring up the brain s vision centers identification of splunc s enac inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways new proteins to clear the airways in cystic fibrosis and copd the divergent roles of dietary saturated and monounsaturated fatty acids on nerve function in murine models of obesity healthy fats improve nerve function in obese mice weak grip strength and cognition predict functional limitation in older europeans older adults with strong grip good memory may avoid or delay disability penetrative trace fossils from the late ediacaran of mongolia early onset of the agronomic revolution digging up the precambrian fossil burrows show early origins of animal behavior the bull of wall street experimental analysis of testosterone and asset trading raging bull first study to find link between testosterone and stock market instability efficacy of etanercept in the tumor necrosis factor receptor associated periodic syndrome traps study shows benefits limits of therapy for rare inflammatory syndrome interactional justice at work is related to sickness absence a study using repeated measures in the swedish working population being treated unfairly at work increases risk of long term sick leave asparagine endopeptidase cleaves synuclein and mediates pathologic activities in parkinson s disease drug discovery alzheimer s and parkinson s spurred by same enzyme redesigning inpatient care testing the effectiveness of an accountable care team model redesigning inpatient care transforming health care one unit at a time increased avian diversity is associated with lower incidence of human west nile infection observation of the dilution effect diversity of birds buffer against west nile virus presence of an epigenetic signature of prenatal cigarette smoke exposure in childhood blood from small children remembers prenatal smoking exposure the hidden burden of dengue and chikungunya in chennai india burden of dengue chikungunya in india far worse than understood amphetamines for attention deficit hyperactivity disorder adhd in adults short term use of amphetamines can improve adhd symptoms in adults review finds external determinants of veterans utilization of va health care use of va services impacted by external economic policy changes neural substrates of cue reactivity and craving in gambling disorder gambling addiction triggers the same brain areas as drug and alcohol cravings migration triggers in a large herbivore gal pagos giant tortoises navigating resource gradients on volcanoes giant tortoises migrate unpredictably in the face of climate change enhancement of inhibitory neurotransmission by gabaa receptors having subunits ameliorates behavioral deficits in a mouse model of autism low doses of antianxiety drugs rebalance autistic brain study shows strengthened scientific support for the endangerment finding for atmospheric greenhouse gases scientific basis for epa s endangerment finding is stronger than ever a dynamic eco evolutionary model predicts slow response of alpine plants to climate warming extinction of alpine plants may remain undetectable for a long time klotho related molecules upregulated by smoking habit in apparently healthy men a cross sectional study smoking habits found to change blood serum concentration of aging related molecules advanced lithium sulfur batteries enabled by a bio inspired polysulfide adsorptive brush next generation smartphone battery inspired by the gut identification of new prostate cancer susceptibility loci using the icogs custom genotyping array genetic spelling mistakes that increase risk of common cancers determined obesity is associated with increased health care charges in patients undergoing outpatient plastic surgery obesity linked to increased health care costs after plastic surgery atp hydrolysis by upf is required for efficient translation termination at premature stop codons essential quality control system in cells identifies and destroys faulty genetic material susceptibility of european freshwater fish to climate change species profiling based on life history and environmental characteristics mediterranean freshwater fish species susceptible to climate change tumor metastasis to lymph nodes requires yap dependent metabolic adaptation how do metastatic tumor cells grow in lymph nodes ? learning trajectory preferences for manipulators via iterative improvement knife wielding robot trains for grocery checkout job using new coactive learning technique physical activity and heart failure risk in a prospective study of men moderate physical activity associated with lower risk of heart failure in men restoration of tumour growth suppression in vivo via systemic nanoparticle mediated delivery of pten mrna nanoparticle therapeutic restores function of tumor suppressor in prostate cancer timing of pharmacologic venous thromboembolism prophylaxis in severe traumatic brain injury a propensity matched cohort study preventive therapy in brain injured patients lowers risk of pulmonary embolism dvt projected coding intensity in medicare advantage could increase medicare spending by billion over ten years medicare could overpay medicare advantage plans by billion over ten years nationwide incidence of metastatic cutaneous squamous cell carcinoma in england skin cancer rates in england far higher than previously thought according to new database the tahoe sierra frontal fault zone emerald bay area lake tahoe california history displacements and rates underwater surveys in emerald bay reveal the nature and activity of lake tahoe faults multiclass method for fast determination of veterinary drug residues in baby food by ultra high performance liquid chromatography tandem mass spectrometry new method detects traces of veterinary drugs in baby food the contribution of socio economic position to the excesses of violence and intimate partner violence among aboriginal versus non aboriginal women in canada socio economic status influences risk of violence against aboriginal women childbirth and female sexual function later in life childbirth not significant contributor to later sexual dysfunction mertk receptor tyrosine kinase is a therapeutic target in melanoma inhibiting macrophage mertk signaling creates an innate immune response against cancer caching behaviour by red squirrels may contribute to food conditioning of grizzly bears do squirrels teach bears to cross the railroad ? grizzlies dig squirrel middens for grains dual inactivation of akt and erk by tic signals foxo a nuclear translocation trail gene induction and potent antitumor effects compound stimulates tumor fighting protein in cancer therapy microgravity promotes osteoclast activity in medaka fish reared at the international space station fishing for answers on bone loss in space pectoral girdle and forelimb musculoskeletal function in the echidna tachyglossus aculeatus insights into mammalian locomotor evolution modeling echidna forelimbs to shed new light on mammal evolution development and clinical validation of the genedrive point of care test for qualitative detection of hepatitis c virus hepatitis c a novel point of care assay tissue stiffness and hypoxia modulate the integrin linked kinase ilk to control breast cancer stem like cells stiff oxygen deprived tumors promote spread of cancer sleep promotes consolidation of emotional memory in healthy children but not in children with attention deficit hyperactivity disorder brain activity in sleep may impact emotional disturbances in children with adhd a new bee species that excavates sandstone nests between a rock and a hard place biologists unearth sandstone excavating bees a low glycemic load diet reduces serum c reactive protein and modestly increases adiponectin in overweight and obese adults diet rich in slowly digested carbs reduces markers of inflammation in overweight and obese adults thioredoxin mimetic peptides protect cognitive function after mild traumatic brain injury mtbi single dose protects cognitive function after mild traumatic brain injury middle stone age ochre processing and behavioural complexity in the horn of africa evidence from porc epic cave dire dawa ethiopia middle stone age ochre processing tools reveal cultural and behavioural complexity inhibitors of nucleotidyltransferase superfamily enzymes suppress herpes simplex virus replication enzyme inhibitors suppress herpes simplex virus replication study finds episodic fault creep events in california controlled by shallow frictional heterogeneity new explanation for slow earthquakes on san andreas aseg rate an intervention program against cyberbullying based on teachers commitment and on design of its instructional materials parental behavior affects the involvement of children in cyberbullying microbiota regulate the ability of lung dendritic cells to induce iga class switch recombination and generate protective gastrointestinal immune responses commensal bacteria regulate immune cells in lungs to produce proteins for host defense chloride capture using a c h hydrogen bonding cage building a better salt trap scientists synthesize a molecular cage to trap chloride nlrp negatively regulates innate immunity and host defence against bacterial pathogens innate immune system protein provides a new target in war against bacterial infections the shiny cowbird molothrus bonariensis gmelin aves icteridae at m asl in quito ecuador new immigrant shiny cowbirds noted from a recording altitude of m in ecuador hiv and tuberculosis co infection among hispanics in southern california an increasing health disparity burden of hiv tb infections increasingly falling on hispanic community expanding children s food experiences the impact of a school based kitchen garden program school based kitchen gardens are getting an a new study highlights benefits of for both children and parents the nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype scientists identify unique subtype of eczema linked to food allergy rna guided human gene activation by crispr cas based engineered transcription factors broad scale genome tinkering with help of an rna guide biotechnology tool borrowed from pathogenic bacteria impact of monovalent rotavirus vaccine on diarrhoea associated post neonatal infant mortality in rural communities in malawi a population based birth cohort study rotavirus vaccine cuts infant diarrhea deaths by a third in malawi control of influenza infection is impaired by diminished interferon secretion by cd t cells in the lungs of toddler mice key difference in immune cells may explain children s increased susceptibility to illness impact of pharmacist administration of influenza vaccines on uptake in canada flu vaccine uptake slightly higher in provinces that allow vaccination by pharmacists genome re sequencing reveals the history of apple and supports a two stage model for fruit enlargement new genomic insights reveal a surprising two way journey for apple on the silk road wafer scale growth and characterization of edge specific graphene nanoribbons for nanoelectronics promising steps towards large scale production of graphene nanoribbons for electronics a legume genetic framework controls infection of nodules by symbiotic and endophytic bacteria legumes control infection of nodules by both symbiotic endophytic bacteria an extremely low density human population exterminated new zealand moa new zealand s moa were exterminated by an extremely low density human population antibiotic exposure as a risk factor for fluconazole resistant candida bloodstream infection experimental vaccine elicits robust response against both hiv and tuberculosis study suggests effects of tomato and soy on serum adipokine concentrations in postmenopausal women at increased breast cancer risk a cross over dietary intervention trial diet rich in tomatoes may lower breast cancer risk erythropoietin doping in cycling lack of evidence for efficacy and a negative risk benefit epo erythropoietin doping in elite cycling no evidence of benefit but high risk of harm wearing a bicycle helmet can increase risk taking and sensation seeking in adults helmet wearing increases risk taking and sensation seeking engineered cationic antimicrobial peptides ecaps to overcome multidrug resistance by eskape pathogens new drug proves effective against antibiotic resistant superbugs complications associated with autologous rib cartilage use in rhinoplasty long term complication rate low in nose job using patient s own rib cartilage development of potent small molecule inhibitors to drug the undruggable steroid receptor coactivator new class of small molecule drug si has potential for improving cancer treatment medium range predictability of early summer sea ice thickness distribution in the east siberian sea based on the topaz ice ocean data assimilation system arctic cyclone limits the time scale of precise sea ice prediction in northern sea route ? lineage restricted mammary stem cells sustain the development homeostasis and regeneration of the estrogen receptor positive lineage estrogen receptor stem cells found in mammary glands effects of posted point of sale warnings on alcohol consumption during pregnancy and on birth outcomes signs point to reduced drinking by pregnant women jumping over a low hurdle personal pension fund performance pension benchmarks give consumers false impression of fund performance cortical efferents lacking mutant huntingtin improve striatal neuronal activity and behavior in a conditional mouse model of huntington s disease broken cellular communication in brain contributes to huntington s disease symptoms the influence of number and timing of pregnancies on breast cancer risk for women with brca or brca mutations number and timing of pregnancies influence breast cancer risk for women with brca or brca mutation longitudinal associations of physical activity and sedentary time with cardiometabolic risk factors in children increasing vigorous exercise decreases risk of type two diabetes cardiovascular disease in childhood metabolic syndrome and cognitive decline in french elders the three city study metabolic syndrome linked to memory loss in older people abnormal neurodevelopmental outcomes are common in children with transient congenital hyperinsulinism recognising low blood sugars could help prevent brain damage in newborn babies bioethics and the framing of climate change s health risks polar bears aren t the only victims of climate change total western diet twd alters mechanical and thermal sensitivity and prolongs hypersensitivity following complete freund s adjuvant in mice typical american diet can worsen chronic pain research shows current heavy alcohol consumption is associated with greater cognitive impairment in older adults older adults with long term alcohol dependence lose neurocognitive abilities the relationship between outcome prediction and cognitive fatigue a convergence of paradigms link found between cognitive fatigue and effort and reward prerelease buzz evolution patterns and new product performance online buzz forecasts new product performance months before product release light induced depigmentation in planarians models the pathophysiology of acute porphyrias flatworms left in sunlight spur investigations into rare metabolic disorders mediterranean dietary pattern is associated with low risk of aggressive prostate cancer mcc spain study a more complete mediterranean diet may protect against aggressive prostate cancer hpv vaccination practices among juvenile justice facilities in the united states most states offer hpv vaccinations to girls in juvenile justice system vitamin d and vitamin d analogues for preventing fractures in post menopausal women and older men vitamin d with calcium may prevent bone fractures for high risk seniors sex specific offspring discrimination reflects respective risks and costs of misdirected care in a poison frog female frogs identify own offspring using inner gps structural basis for human nadph cytochrome p oxidoreductase deficiency enzyme s structure reveals basis for head reproductive organ deformities cancer exosomes perform cell independent microrna biogenesis and promote tumorigenesis how do breast cancer cells transform normal cells into tumoral ones ? widely dispersed intermolecular valence bands of epitaxially grown perfluoropentacene on pentacene single crystals tracking charge carriers in the molecular crystal at organic pn junction do sperm really compete and do eggs ever have a choice ? adult distribution and gamete mixing influence sexual selection sexual conflict and the evolution of gamete recognition proteins in the sea rival sperm and choosy eggs when sperm compete eggs have a choice sex differences in perceived stress and early recovery in young and middle aged patients with acute myocardial infarction stress linked to worse recovery in women after heart attack genome wide diet gene interaction analyses for risk of colorectal cancer gene variant increases risk of colorectal cancer from eating processed meat shallow structure and geomorphology along the offshore northern san andreas fault tomales point to fort ross california signs of earthquake revealed in mapping of offshore northern san andreas fault a conformationally frozen peptoid boosts cxcr affinity and anti hiv activity potential drug molecule shows enhanced anti hiv activity human specific derived alleles of cd and other genes protect against postreproductive cognitive decline newly evolved uniquely human gene variants protect older adults from cognitive decline rna polymerase iii subunit polr g regulates specific subsets of polya and smallrna transcriptomes and splicing in human pluripotent stem cells new insights into mechanisms regulating gene expression in embryonic stem cells katnal regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility new type of male contraceptive ? key gene essential for sperm development discovered rapidly changing environment modulates the thermoregulatory fanning response in honeybee groups honeybees more likely to regulate hive s thermostat during rapid temperature increases a population of heterogeneous breast cancer patient derived xenografts demonstrate broad activity of parp inhibitor in brca wild type tumors parp inhibitor may be effective against some tnbc lacking brca mutations non destructive elemental analysis of a carbonaceous chondrite with direct current muon beam at music development on muon beam analysis of organic matter in samples from space biochemical characterization of major bone matrix proteins using nanoscale size bone samples and proteomics methodology new technique yields troves of information from nanoscale bone samples release of genetically engineered insects a framework to identify potential ecological effects new approach to identify possible ecological effects of releasing genetically engineered insects historical versus contemporary climate forcing on the annual nesting variability of loggerhead sea turtles in the northwest atlantic ocean loggerhead sea turtle nesting activity driven by recent climate conditions pulmonary arterial hypertension treatment with carvedilol for heart failure a randomized controlled trial beta blockers have positive effect in pulmonary arterial hypertension researchers find dietary protein sources in early adulthood and breast cancer incidence prospective cohort study estimated risk of breast cancer increases as red meat intake increases study suggests her mutations in lung adenocarcinomas a report from the lung cancer mutation consortium breast cancer driver her in percent of lung cancers study finds climate engineering induced changes in correlations between earth system variables implications for appropriate indicator selection potential effects of large scale projects designed to offset earth s changing climate motivating latino smokers to quit does type of social support matter ? helping latinos quit smoking studies offers new insight aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats exercise training in heart failure shaping your proteins a mutation in sigma receptor causes juvenile amyotrophic lateral sclerosis mutation in sigmar gene linked to juvenile amyotrophic lateral sclerosis sigma receptor offers potential therapeutic target the relationship between professional burnout and quality and safety in healthcare a meta analysis psychologists analyze links between provider burnout quality of care patient safety hidden vegetables an effective strategy to reduce energy intake and increase vegetable intake in adults hiding vegetables in kids foods can increase vegetable intake metabolic syndrome in liver transplant recipients prevalence risk factors and association with cardiovascular events metabolic syndrome found in percent of patients after liver transplantation connectivity neurofeedback training can differentially change functional connectivity and cognitive performance manipulating brain network to change cognitive functions new breakthrough in neuroscience spatial scaling of arbuscular mycorrhizal fungal diversity is affected by farming practice farm management choice can benefit fungi key to healthy ecosystems effect of using the heart score in patients with chest pain in the emergency department a stepped wedge cluster randomized trial heart score to risk stratify patients with chest pain is safe but underutilized in the ed nanoparticle delivery of curcumin induces cellular hypoxia and ros mediated apoptosis via modulation of bcl bax in human neuroblastoma nanoparticles loaded with component of common spice kill cancer cells large scale plasma lipidomic profiling identifies lipids that predict cardiovascular events in secondary prevention scientists developing new blood test to screen for secondary heart attack long term microdystrophin gene therapy is effective in a canine model of duchenne muscular dystrophy gene therapy microdystrophin restores muscle strength in duchenne muscular dystrophy acidity and antioxidant activity of cold brew coffee hot brew coffee has higher levels of antioxidants than cold brew quantifying phenotypic flexibility as the response to a high fat challenge test in different states of metabolic health even a little is too much one junk food snack triggers signals of metabolic disease cancer development progression and therapy an epigenetic overview researchers study epigenetic mechanisms of tumor metastasis for improved cancer therapy cardiovascular risk factors from childhood and midlife cognitive performance heart disease risks experienced in childhood impact cognition later in life common variants at five new loci associated with early onset inflammatory bowel disease largest gene study of childhood inflammatory bowel disease identifies five new genes scope scale and dose of the world s largest school based mental health programs mental health programs in schools growing body of evidence supports effectiveness cellular antioxidant and anti inflammatory effects of coffee extracts with different roasting levels does roasting level affect the antioxidant anti inflammatory properties of coffee beans ? mutation in folate metabolism causes epigenetic instability and transgenerational effects on development folic acid deficiency can affect the health of great great grandchildren epidemiologic characteristics of children with blood lead levels g dl severe lead poisoning in children causes and risk factors hypoxia activates cadherin synthesis via eif e to drive cancer cell migration invasion and adhesion protein key to cancer cells ability to spread identified interventions to improve the mental health of children and young people with long term physical conditions linked evidence syntheses cognitive behavioral therapy for kids with long term conditions long term effects of institutional rearing foster care and brain activity on memory and executive functioning early child deprivation and neglect impair memory and executive functioning at age yield stability differs in commercial maize hybrids in response to changes in plant density nitrogen fertility and environment corn hybrids with high yields come with more variability high depth sequencing of over genes supports linear progression of primary tumors and metastases in most patients with liver limited metastatic colorectal cancer mutations that may enable earlier diagnosis of colorectal cancer recurrence identified microarray analysis of bone marrow lesions in osteoarthritis demonstrates upregulation of genes implicated in osteochondral turnover neurogenesis and inflammation new genes linked to arthritis in bone marrow lesions project tendr targeting environmental neuro developmental risks the tendr consensus statement a host of common chemicals endanger child brain development maternal immunity and antibodies to dengue virus promote infection and zika virus induced microcephaly in fetuses mother s dengue immunity worsens baby s response to zika genome wide association mapping in dogs enables identification of the homeobox gene nkx as a genetic component of neural tube defects in humans gene mutation in dogs offers clues for neural tube defects in humans computer aided screening of conjugated polymers for organic solar cell classification by random forest ai software assists design of new material for solar cells association of aspirin and nsaid use with risk of colorectal cancer according to genetic variants link between aspirin nsaids and colon cancer prevention may hinge on genetic variations rhoa gtpase controls cytokinesis and programmed necrosis of hematopoietic progenitors study identifies essential molecule in formation of differentiated blood cells variations in infant feeding practice are associated with body composition in childhood a prospective cohort study breastfeeding duration and weaning diet may shape child s body composition did sea level change cause the switch from fissure type to central type volcanism at mount etna sicily ? did highest known sea levels create the iconic shape of mount etna ? induced pluripotent stem cell derived neural stem cell therapy enhances recovery in an ischemic stroke pig model the rat race is over new livestock model for stroke could speed discovery a designer self assembled supramolecule amplifies macrophage immune responses against aggressive cancer eat em up next generation therapeutic helps immune cells detect destroy cancer autograft derived spinal cord mass following olfactory mucosal cell transplantation in a spinal cord injury patient spinal cord mass arising from neural stem cell therapy genotypic and functional impact of hiv adaptation to its host population during the north american epidemic researchers trace hiv adaptation to its human host redox dependent niche differentiation provides evidence for multiple bacterial sources of glycerol tetraether lipids in lakes improving paleotemperature reconstruction swiss lakes as a model system increased scalp hair cortisol concentrations in obese children obese children have higher stress hormone levels than normal weight peers transmission of chimeric hiv by mating in conventional mice prevention by pre exposure antiretroviral therapy and reduced susceptibility during estrus the first animal model for sexual transmission of hiv disruption of the circadian clock in mice increases intestinal permeability and promotes alcohol induced hepatic pathology and inflammation it s about time disrupted internal clocks play role in disease maternal blood pressure rise during pregnancy and offspring obesity risk at years old the jiaxing birth cohort expectant mother s elevated blood pressure raises child s risk of obesity conformational changes during pore formation by the perforin related protein pleurotolysin carnivorous mushroom reveals human immune trick how we punch our way into cancer cells tea consumption reduces the incidence of neurocognitive disorders findings from the singapore longitudinal aging study daily consumption of tea may protect the elderly from cognitive decline study suggests abnormal degradation of the neuronal stress protective transcription factor hsf in huntington s disease cellular quality control process could be huntington s disease drug target the long arm of parental addictions the association with adult children s depression in a population based study parental addictions linked to adult children s depression wrist fracture and risk of subsequent fracture findings from the women s health initiative study wrist fractures could predict susceptibility to serious fractures in postmenopausal women seven new loci associated with age related macular degeneration seven genetic risk factors found to be associated with common eye disorder comparison of green and albino individuals of the partially mycoheterotrophic orchid epipactis helleborine on molecular identities of mycorrhizal fungi nutritional modes and gene expression in mycorrhizal roots genes in albino orchids may hold clues to parasitic mechanism used by non photosynthetic plants breast cancer risk associated snps modulate the affinity of chromatin for foxa and alter gene expression snps associated with breast cancer risk alter binding affinity for pioneer factor foxa fgf underlies a hormetic response to metabolic stress in methylmalonic acidemia elevated hormone flags liver problems in mice with methylmalonic acidemia long term mortality after blood pressure lowering and lipid lowering treatment in patients with hypertension in the anglo scandinavian cardiac outcomes trial ascot legacy study year follow up results of a randomised factorial trial blood pressure and cholesterol lowering drugs continue to improve survival after a decade using tele emergency to avoid patient transfers in rural emergency departments an assessment of costs and benefits patients in rural hospitals can save thousands of dollars if local hospital is part of tele emergency room network biomechanical evaluation of suture anchor versus transosseous tunnel quadriceps tendon repair techniques minimally invasive tendon repair technique supports knee movement sooner after surgery dna priming and influenza vaccine immunogenicity two phase open label randomized clinical trials priming with dna vaccine makes avian flu vaccine work better proof of concept for universal influenza vaccine association of infertility and fertility treatment with mammographic density in a large screening based cohort of women a cross sectional study potential effects of fertility treatments on breast density cancer risk access to primary health care among homeless adults in toronto canada results from the street health survey no health card means no family doctor for many homeless people in ontario hospitalizations for mitochondrial disease across the lifespan in the u.s. mitochondrial disease has a disproportionate healthcare burden in us role of mitochondrial dna damage and dysfunction in veterans with gulf war illness dna damage found in veterans with gulf war illness evaluating a new method for reconstructing forest conditions from general land office survey records study refutes findings behind challenge to sierra nevada forest restoration quantifying compressive forces between living cell layers and within tissues using elastic round microgels elastic microspheres expand understanding of embryonic development and cancer cells integrative taxonomy and phylogeny based species delimitation of philippine water monitor lizards varanus salvator complex with descriptions of two new cryptic species undercover researchers expose new species of lizard for sale on philippine black market cost effectiveness of human papillomavirus test of cure after treatment for cervical intraepithelial neoplasia in england economic analysis from nhs sentinel sites study cheaper and more effective test available for women following pre cervical cancer treatment study suggests sex biases in distribution and resource use at different spatial scales in a migratory shorebird environmental change impacts on migratory shorebirds differ for males and females smarcad contributes to the regulation of naive pluripotency by interacting with histone citrullination discovery of a new regulatory protein provides new tool for stem cell engineering unintentional childhood poisonings through ingestion of conventional and novel tobacco products tobacco company s new dissolvable nicotine products could lead to accidental poisoning a novel truncated form of ikk is responsible for specific nuclear ikk activity in colorectal cancer new function of protein involved in colon cancer identified using web search query data to monitor dengue epidemics a new model for neglected tropical disease surveillance searching the web for dengue early detection and monitoring of outbreaks of an emerging mosquito borne virus chagas cardiomyopathy an update of current clinical knowledge and management a scientific statement from the american heart association chagas disease has spread outside of latin america and carries high risk of heart disease a new species of the late cretaceous sail finned bony fish pentanogmius actinopterygii tselfatiiformes from texas usa fish of dinosaur era with unique hook shaped sail on its back early behavioral intervention is associated with normalized brain activity in young children with autism autism early intervention found to normalize brain activity in children as young as months a preliminary study on the feasibility of using a virtual reality cognitive training application for remote detection of mild cognitive impairment mild cognitive impairment mci detected with brain training game metabolic testing rates in state medicaid programs after fda warnings and ada apa recommendations for second generation antipsychotic drugs monitoring of high risk antipsychotic drugs unchanged despite fda warnings roads and livelihood activity choices in the greater serengeti ecosystem tanzania when development and conservation clash in the serengeti inverse association of the endogenous thrombin potential etp with cardiovascular death the ludwigshafen risk and cardiovascular health luric study cushing s syndrome researchers characterize new tumor syndrome identifying peach and plum polyphenols with chemopreventive potential against estrogen independent breast cancer cells peaches plums induce deliciously promising death of breast cancer cells preliminary evaluation of the energy saving behavior of a novel household refrigerator scientists discover potential sustainable energy technology for the household refrigerator dogs showing separation related behaviour exhibit a pessimistic cognitive bias dogs showing separation related behavior exhibit a pessimistic mood reversal of cellular phenotypes in neural cells derived from huntington s disease monkey induced pluripotent stem cells disease in a dish approach could aid huntington s disease discovery application of deacetylated poly n acetyl glucosamine nanoparticles for the delivery of mir for the treatment of cecal ligation and puncture induced sepsis targeting sepsis the leading cause of icu deaths with a nanocarrier delivered microrna intracoronary cardiosphere derived cells for heart regeneration after myocardial infarction caduceus a prospective randomised phase trial how experimental regenerative medicine therapies can regrow damaged heart muscle beta catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in t cells beta catenin alters t cells in lasting harmful ways polygenic risk and neural substrates of attention deficit hyperactivity disorder symptoms in youths with a history of mild traumatic brain injury study identifies distinct origin of adhd in children with history of brain injury beauty is in the eye of the beer holder an initial investigation of the effects of alcohol attractiveness warmth and competence on the objectifying gaze in men beauty is in the eye of the beer holder quiescent haematopoietic stem cells are activated by ifn in response to chronic infection gamma interferon a wake up call for stem cell response to infection fitness costs of increased cataract frequency and cumulative radiation dose in natural mammalian populations from chernobyl radiation causes blindness in wild animals in chernobyl reprogramming human t cell function and specificity with non viral genome targeting t cell engineering breakthrough sidesteps need for viruses in gene editing imprinting defects at human q locus alters gene expression and is associated with the pathobiology of osteosarcoma dna imprinting defects associated with childhood osteosarcoma development progression phylogenetic analysis reveals common antimicrobial resistant campylobacter coli population in antimicrobial free abf and commercial swine systems antibiotic resistant pathogens persist in antibiotic free pigs scab inspired cytophilic membrane of anisotropic nanofibers for rapid wound healing human scabs serve as inspiration for new bandage to speed healing prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice prenatal vitamin a deficiency tied to postnatal asthma anthropogenic noise alters dwarf mongoose responses to heterospecific alarm calls lost in translation traffic noise disrupts communication between species human induced pluripotent stem cell derived models to investigate human cytomegalovirus infection in neural cells new light shed on virus associated with developmental delays and deafness old age expectations are related to how long people want to live how long do you want to live ? your expectations for old age matter effect of annatto extracted tocotrienols and green tea polyphenols on glucose homeostasis and skeletal muscle metabolism in obese male mice green tea cuts obesity health risks in mice environmental and state level regulatory factors affect the incidence of autism and intellectual disability autism intellectual disability incidence linked with environmental factors transvaginal mesh or grafts compared with native tissue repair for vaginal prolapse new evidence gives women informed choice in the prolapse surgery debate association of antidepressant medication use during pregnancy with intellectual disability in offspring no statistically significant risk of intellectual disability in children from mothers using antidepressants ancient record of changing flows from wave ripple defects beach sand ripples can be fingerprints for ancient weather conditions mutant huntingtin is present in neuronal grafts in huntington s disease patients healthy tissue grafted to brains of huntington s patients also develops the disease chronic obstructive pulmonary disease and long term exposure to traffic related air pollution a cohort study air pollution exposure increases risk of severe copd the rediscovered hula painted frog is a living fossil an extinct frog makes a comeback in israel a little known endemic caught in the south east asian extinction crisis the annamite striped rabbit nesolagus timminsi fading stripes in southeast asia first insight into the ecology of a threatened rabbit generation of integration free and region specific neural progenitors from primate fibroblasts adult cells transformed into early stage nerve cells bypassing the pluripotent stem cell stage a small molecule screen exposes mtor signaling pathway involvement in radiation induced apoptosis amid terror threats new hope for radiation antidote forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice support cells found in human brain make mice smarter pembrolizumab plus chemotherapy in metastatic non small cell lung cancer combination therapy doubles survival in metastatic lung cancer long term stability and safety of transgeni cultured epidermal stem cells in gene therapy of junctional epidermolysis bullosa gene therapy for human skin disease produces long term benefits benefits of the paris agreement to ocean life economies and people achieving paris climate target could net additional billions in fisheries revenue when math hurts math anxiety predicts pain network activation in anticipation of doing math when people worry about math the brain feels the pain childhood trauma and psychosis in a prospective cohort study cause effect and directionality new evidence shows link between childhood trauma and psychotic experiences robust abatement pathways to tolerable climate futures require immediate global action few pathways to an acceptable climate future without immediate action national estimation of children in residential care institutions in cambodia a modelling study one percent of cambodian children live in orphanages yet have a living parent commonalities in development of pure breeds and population isolates revealed in the genome of the sardinian fonni s dog genome of fiercely protective fonni s dog reflects human history of sardinia changes in health care costs over time following the cessation of intimate partner violence domestic violence victims have higher health costs for years after abuse ends dengue virus immunity increases zika virus induced damage during pregnancy dengue virus infection may cause severe outcomes following zika virus infection during pregnancy a recurrent de novo mutation in actg causes isolated ocular coloboma gene study sheds light on causes of childhood sight loss complementarity and redundancy of il producing innate lymphoid cells immune cells make appendix silent hero of digestive health prenatal alcohol exposure alters biobehavioral reactivity to pain in newborns prenatal alcohol exposure can alter the brain s developing pain regulatory system nitrogen source for inflorescence development in phalaenopsis i. relative significance of stored and newly absorbed nitrogen nitrogen source determined significant for inflorescence development in phalaenopsis ets transcription factors induce a unique uv damage signature that drives recurrent mutagenesis in melanoma dna damage links to onset of skin cancer melanoma mapped childhood socioeconomic status and arterial stiffness in adulthood childhood socioeconomic status associated with arterial stiffness in adulthood distribution of magnetic remanence carriers in the human brain mapping of magnetic particles in the human brain the response of relativistic outflowing gas to the inner accretion disk of a black hole rapid changes point to origin of ultra fast black hole burp menopausal hormone therapy and risk of cholecystectomy a prospective study based on the french e n cohort oral estrogen hormone therapy linked to increased risk of gallbladder surgery in menopausal women neuropsychological deficit profiles vascular risk factors and neuropathological findings in hispanic older adults with autopsy confirmed alzheimer s disease in life and death alzheimer s disease looks different among hispanic patients resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins overcoming inhibitors of cell death improves cancer therapy efficacy yogurts with an increased protein content and physically modified starch rheological structural oral digestion and sensory properties related to enhanced satiating capacity researchers formulate new yogurts with high protein content higher satiating capacity elevated mmp in the lumbar cord early after thoracic spinal cord injury impedes motor relearning in mice treadmill training after spinal cord injury promotes recovery when inflammation is controlled the evidence for saturated fat and for sugar related to coronary heart disease sugar consumption plays greater role in heart disease than saturated fat massachusetts health reform s effect on hospitals racial mix of patients and on patients use of safety net hospitals safety net hospitals remain vital resource for minority patients following health reform fractionation spares mice from radiation induced reductions in weight gain but does not prevent late oligodendrocyte lineage side effects conventional radiation therapy may not protect healthy brain cells long term consumption of sugar sweetened and artificially sweetened beverages and risk of mortality in us adults higher consumption of sugary beverages linked with increased risk of early mortality in vivo imaging of influenza virus infection in immunized mice real time imaging in mice a promising influenza study tool circadian gene circuitry predicts hyperactive behavior in a mood disorder mouse model infradian oscillation of circadian genes in a mouse model of bipolar disorder encounter with mesoscale eddies enhances survival to settlement in larval coral reef fishes eddies enhance survival of coral reef fish in sub tropical waters catch rates and income are associated with fisheries management restrictions and not an environmental disturbance in a heavily exploited tropical fishery climate change impacts countered by stricter fisheries management fgf gene therapy as treatment for obesity and insulin resistance gene therapy shown to cure type diabetes and obesity in mice researchers report clinical evaluation of mtc rituximab for sentinel lymph node mapping in breast cancer patients novel tracer safely and effectively maps sentinel lymph nodes in breast cancer patients activity of invasive slug limax maximus in relation to climate conditions based on citizen s observations and novel regularization based statistical approaches citizen science a powerful tool to combat invasive giant slugs skeletal indicators of shark feeding on human remains evidence from florida forensic anthropology cases shark scavenging helps reveal clues about human remains biogeochemical hotspots role of small water bodies in landscape nutrient processing destruction of wetlands linked to algal blooms in great lakes theta oscillations regulate the speed of locomotion via a hippocampus to lateral septum pathway green waves in the brain theta oscillations coordinate navigation and movement using solitary ascidians to assess microplastic and phthalate plasticizers pollution among marine biota a case study of the eastern mediterranean and red sea microplastics and plastic additives discovered in ascidians all along israel s coastline echo autism using technology and mentorship to bridge gaps increase access to care and bring best practice autism care to primary care telehealth reduces wait time improves care for children with autism living in remote areas zika virus impairs growth in human neurospheres and brain organoids damaging consequences of zika virus infection in human minibrains intervention to improve level of overall functioning and mental condition of adolescents at high risk of developing first episode psychosis in finland early and network oriented care may help adolescents at risk of developing psychosis young adulthood cognitive ability predicts statin adherence in middle aged men after first myocardial infarction a swedish national registry study men with superior higher cognitive ability better at taking heart medication antibody against early driver of neurodegeneration cis p tau blocks brain injury and tauopathy new antibody treats traumatic brain injury and prevents long term neurodegeneration fear learning circuitry is biased toward generalization of fear associations in posttraumatic stress disorder brain regions of ptsd patients show differences during fear responses cd t cells regulate tumour ferroptosis during cancer immunotherapy new target to improve response to cancer immunotherapy corticostriatal plasticity is necessary for learning intentional neuroprosthetic skills study shows brain flexibility gives hope for natural feeling neuroprosthetics introduced bullfrog facilitates pathogen invasion in the western united states new evidence that bullfrogs are to blame for deadly fungus outbreaks in western us ethnic disparities in coronary heart disease management and pay for performance in the uk money motivates doctors to reduce ethnic differences in heart disease treatments uk study finds climatic control of mississippi river flood hazard amplified by river engineering human engineered changes on mississippi river increased extreme floods genome wide association and hla fine mapping studies identify risk loci and genetic pathways underlying allergic rhinitis world s largest study on allergic rhinitis reveals new risk genes infant hiv gp vaccination elicits robust and durable anti v v igg responses and only rare envelope specific iga responses new analysis of old hiv vaccines finds potentially protective immune response genetic diagnosis of high penetrance susceptibility for colorectal cancer crc is achievable for a high proportion of familial crc by exome sequencing study makes case for wider gene testing in bowel cancer geophysical evidence for a san andreas subparallel transtensional fault along the northeastern shore of the salton sea earthquake risk new fault discovered in earthquake prone southern california region absence of cytomegalovirus in glioblastoma and other high grade gliomas by real time pcr immunohistochemistry and in situ hybridization study finds no evidence of common herpes type virus in aggressive brain cancer tissue routine counseling about intrauterine contraception for women seeking emergency contraception knowledge use of iuds increases when women are offered counseling same day service synuclein fibril induced paradoxical structural and functional defects in hippocampal neurons untangling brain neuron dysfunction in parkinson s disease and dementia with lewy bodies disruption of saturn s quasi periodic equatorial oscillation by the great northern storm giant storms cause palpitations in saturn s atmospheric heartbeat collective pedagogical teacher culture and mathematics achievement differences by race ethnicity and socioeconomic status teacher collaboration professional communities improve many elementary school students math scores different levels of twist regulate skin tumor initiation stemness and progression skin cancer new mechanism involved in tumor initiation growth and progression dietary antioxidants and long term risk of dementia eating foods rich in vitamin e associated with lower dementia risk pretreatment of carprofen impaired initiation of inflammatory and overlapping resolution response and promoted cardiorenal syndrome in heart failure nsaid impairs immune response in heart failure worsens heart and kidney damage the geography of crime and violence surrounding tobacco shops medical marijuana dispensaries and off sale alcohol outlets in a large urban low income community of color tobacco shops associated with crime in urban communities of color evaluation of breast lipid composition in patients with benign tissue and cancer by using multiple gradient echo mr imaging new approach to mri imaging links saturated fats to breast cancer in postmenopausal women metabolomics investigation to shed light on cheese as a possible piece in the french paradox puzzle new piece in the french paradox diet and health puzzle cheese metabolism new firework caused severe eye injuries at a public display new firework causes severe eye injuries warn doctors distinct p genomic binding patterns in normal and cancer derived human cells first analysis of tumor suppressor interactions with whole genome in normal human cells reveals key differences with cancer cells a new species of manakin aves pipridae machaeropterus from peru with a taxonomic reassessment of the striped manakin m. regulus complex new peruvian bird species discovered by its song association of nausea and vomiting during pregnancy with pregnancy loss morning sickness linked to lower risk of pregnancy loss dust density waves in a dc flowing complex plasma with discharge polarity reversal aboard the iss researchers investigate complex dust behavior in plasmas carbohydrate microarrays and their use for the identification of molecular markers for plant cell wall composition new approach to unlock the genetic potential of plant cell wall national trends in long term use of prescription opioids long term opioid prescription use jumps threefold over year period study suggests neurotrophin signaling via trkb and trkc receptors promote the growth of brain tumor initiating cells protein pathway involved in brain tumor stem cell growth identified the influence of forage fish abundance on the aggregation of gulf of maine atlantic cod gadus morhua and their catchability in the fishery changes in forage fish abundance alter atlantic cod distribution affect fishery success triggering of acute myocardial infarction by respiratory infection heart attack risk increases fold following respiratory infections differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome gut microbes linked to brain structure in people with irritable bowel syndrome global conservation outcomes depend on marine protected areas with five key features politics and half measures failing marine conservation global study shows the growing human footprint on coastal and open ocean biogeochemistry comprehensive look at human impacts on ocean chemistry fundamental properties of unperturbed haematopoiesis from stem cells in vivo observing stem cells maturing into blood cells in living mouse fate of genetically modified maize and conventional rapeseed and endozoochory in wild boar sus scrofa what happens when wild boars and fallow deer snack on genetically modified corn ? designing river flows to improve food security futures in the lower mekong basin hydropower dam energy without sacrificing mekong food supply new research offers solution fish consumption marine omega fatty acids and incidence of heart failure a population based prospective study of middle aged and elderly men eating fatty fish and marine omega fatty acids may reduce risk of heart failure programming with models modularity and abstraction provide powerful capabilities for systems biology biology enters the matrix through new computer language what do women know about breast density ? results from a population survey of virginia women most women unaware of breast density s effect on cancer risk study finds childhood lead exposure and uptake in teeth in the cleveland area during the era of leaded gasoline leaded gasoline predominant source of lead exposure in latter th century risk of colorectal cancer in men on long term androgen deprivation therapy for prostate cancer colorectal cancer risk increases in prostate cancer patients on androgen deprivation therapy study finds actin retrograde flow actively aligns and orients ligand engaged integrins in focal adhesions internal forces directing cell migration are revealed by live cell microscopy a single dose influenza a h n vaccine safe and immunogenic in adult and elderly patients an approach to pandemic vaccine development single dose h n vaccine safe and effective in adults and elderly mindfulness training improves attentional task performance in incarcerated youth a group randomized controlled intervention trial study on incarcerated youth shows potential to lower anti social behavior topological features of a gene co expression network predict patterns of natural diversity in environmental response gene networks dictate plants responses to cold stress association between value based incentive programs and catheter associated urinary tract infection rates in the critical care setting government payment policies tied to hospital performance fail to improve patient safety study finds patients with type diabetes are missing out on flash glucose devices finds bmj investigation patients with type diabetes missing out on glucose devices cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain researchers identify root of chronic pain as potential new drug target arthropods of the great indoors characterizing diversity inside urban and suburban homes first study of arthropods in us homes finds huge biodiversity use of advanced radiology during visits to us emergency departments for injury related conditions use of advanced radiology for injury related emergency department visits increases significantly night shift work and breast cancer incidence three prospective studies and meta analysis of published studies working night shifts unlikely to increase breast cancer risk physics based computer simulation of the long term effects of cardiac regenerative therapies long term effects of cardiac regenerative therapies in a left ventricle treatment of low bone density or osteoporosis to prevent fractures in men and women a clinical practice guideline update from the american college of physicians guideline for treating low bone density or osteoporosis to prevent fractures tackling inpatient penicillin allergies tools for antimicrobial stewardship skin testing computerized support tool can improve antibiotic use in hospital inpatients a survey of inpatient practitioner knowledge of penicillin allergy at community teaching hospitals pharmacists know more about penicillin allergy than mds study shows sarm activation triggers axon degeneration locally via nad destruction major pathway identified in nerve cell death offers hope for therapies relation of muscle mass and fat mass to cardiovascular disease mortality higher muscle mass associated with lower mortality risk in people with heart disease evaluation of usda soybean germplasm accessions for resistance to soybean rust in the southern united states soybean germplasm evaluations give us a head start against soybean rust pathogen who s still smoking ? disparities in adult cigarette smoking prevalence in the united states who s still smoking report highlights populations still at risk the computational power of interactive recurrent neural networks computer scientist leads the way to the next revolution in artificial intelligence a molecular signature for anastasis recovery from the brink of apoptotic cell death how cells recover from the verge of programmed death cutting edge il receptor promotes resolution of intestinal damage cytokine plays dual role in regulating inflammatory bowel disease study finds sequence related amplified polymorphism srap markers a potential resource for studies in plant molecular biology utility of sequence related amplified polymorphism srap markers understanding the premalignant potential of atypical hyperplasia through its natural history a longitudinal cohort study new data contradict current recommendations for management of breast biopsy abnormalities energy drinks and youth self reported hyperactivity inattention symptoms energy drinks significantly increase hyperactivity in schoolchildren study finds enhancing the cytotoxic effects of parp inhibitors with dna demethylating agents a potential therapy for cancer researchers identify novel mechanism in combination drug therapy for acute myeloid leukemia other cancers wildlife species preferences differ among children in continental and island locations kids wildlife preferences differ from island to mainland unintentional firearm deaths a comparison of other inflicted and self inflicted shootings majority of young victims of unintentional shootings shot by another youth study finds c kit cells minimally contribute cardiomyocytes to the heart caution urged in stem cell clinical trials for heart attack patients inorganic and total arsenic contents in rice based foods for children with celiac disease some rice based foods for people with celiac disease contain relevant amounts of arsenic missing clinical and behavioral health data in a large electronic health record ehr system new study shows electronic health records often capture incomplete mental health data selective ablation of ctip bcl b in epidermal keratinocytes triggers atopic dermatitis like skin inflammatory responses in adult mice researchers discover genetic basis for eczema new avenue to therapies invertebrate population genetics across earth s largest habitat the deep sea floor shocking gaps in basic knowledge of deep sea life catatonia in down syndrome a treatable cause of regression cause of regression in individuals with down syndrome identified interneuron simplification and loss of structural plasticity as markers of aging related functional decline antidepressant restores youthful flexibility to aging inhibitory neurons in mice abnormal cortical growth in schizophrenia targets normative modules of synchronized development brain development in schizophrenia strays from normal path development of an enhanced human gastrointestinal epithelial culture system to facilitate patient based assays growing human gi cells may lead to personalized treatments working with stakeholders to reduce conflict modelling the impact of varying hen harriercircus cyaneusdensities on red grouselagopus lagopuspopulations ecology could break deadlock between grouse shooting hen harrier conservation on uk moorlands sideband cooling beyond the quantum backaction limit with squeezed light physicists squeeze light to cool microscopic drum below quantum limit an autonomously electrically self healing liquid metal elastomer composite for robust soft matter robotics and electronics self healing material a breakthrough for bio inspired robotics towards better public health reporting using existing off the shelf approaches a comparison of alternative cancer detection approaches using plaintext medical data and non dictionary based feature selection machine learning as good as humans in cancer surveillance study shows ips cell modeling of best disease insights into the pathophysiology of an inherited macular degeneration cells from skin create model of blinding eye disease modeling an autism risk factor in mice leads to permanent immune dysregulation new evidence links immune irregularities to autism mouse study suggests host genetic selection for cold tolerance shapes microbiome composition and modulates its response to temperature tropical fish adapt to cold temperatures in coordination with their microbiome lack of tissue renewal in human adult achilles tendon is revealed by nuclear bomb c fallout from nuclear testing shows that the achilles tendon can t heal itself toxicological status of children with autism vs. neurotypical children and the association with autism severity higher levels of several toxic metals found in children with autism ice sheet modulation of deglacial north american monsoon intensification mud from the deep sea reveals clues about ancient monsoon methodology to evaluate the environmental impact of urban solid waste containerization system a case study how does municipal waste collection affect climate change ? exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury stem cells from jaw bone help repair damaged cartilage cap in cardiac conduction sudden cardiac death and eye development heart structural gene causes sudden cardiac death in animal model a wnt tgf axis induces a fibrogenic program in muscle stem cells from dystrophic mice stem cells faulty in duchenne muscular dystrophy researchers find model based scenario planning to develop climate change adaptation strategies for rare plant populations in grassland reserves for a rare prairie orchid science is making climate change local changing polygenic penetrance on phenotypes in the th century among adults in the us population research tracks interplay of genes and environment on physical educational outcomes oysters as sentinels of climate variability and climate change in coastal ecosystems sentinels of the sea at risk from changing climate dynamic dna devices and assemblies formed by shape complementary non base pairing d components designer s toolkit for dynamic dna nanomachines arm waving nanorobot signals new flexibility in dna origami patient physician discordance in assessments of global disease severity in rheumatoid arthritis rheumatoid arthritis patients and doctors differ on disease severity assessment long but not short term estradiol treatment induces renal damage in midlife ovariectomized long evans rats long term use of postmenopausal estrogen treatment may impair kidney function american college of rheumatology guidelines for management of gout part i systematic non pharmacologic and pharmacologic therapeutic approaches to hyperuricemia gout guidelines arm patients and physicians with tools to fight painful disease the predictive effect of fear avoidance beliefs on low back pain among newly qualified health care workers with and without previous low back pain a prospective cohort study back breaking work beliefs contribute to health workers pain direct healthcare costs of sedentary behaviour in the uk spending too much time sitting down linked to around early deaths per year in the uk online e cigarette marketing claims a systematic content and legal analysis unproven claims run rampant in e cigarette business reassessment of the san andreas fault rupture in portola valley california from synthesis of lidar and historical data revised location of rupture of san andreas fault in portola valley predictors of health behaviors after the economic downturn a longitudinal study workplace and financial stress lead to poor health choices leap frog in slow motion divergent responses of tree species and life stages to climatic warming in great basin sub alpine forests earth s oldest trees in climate induced race up the tree line ambient and dosed exposure to quaternary ammonium disinfectants causes neural tube defects in rodents common household chemicals lead to birth defects in mice research finds media violence exposure and aggression in adolescents a risk and resilience perspective media violence impulsivity and family conflict tied to aggressive behaviors in teenagers model projections of rapid sea level rise on the northeast coast of the united states sea level rise due to global warming poses threat to new york city independent evolution of baleen whale gigantism linked to plio pleistocene ocean dynamics whales only recently evolved into giants when changing ice oceans concentrated prey investigating the role of state and local health departments in addressing public health concerns related to industrial food animal production sites health departments hindered in addressing health concerns from animal production sites study finds stepwise differentiation of retinal ganglion cells from human pluripotent stem cells enables analysis of glaucomatous neurodegeneration stem cells used to identify cellular processes related to glaucoma modeling dynamic interactions between pre exposure prophylaxis interventions treatment programs predicting hiv transmission resistance researchers suggest unconventional approach to control hiv epidemics breast milk and in utero transmission of hiv select for envelope variants with unique molecular signatures only a limited hiv subset moves from mother to child study shows tgf and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance of worms and women common causes for reproductive decline with age successful delivery of rrt in ebola virus disease first successful delivery of dialysis in ebola virus disease provided brain pericytes acquire a microglial phenotype after stroke migrating stem cells possible new focus for stroke treatment national estimates of reductions in acute gastroenteritis related hospitalizations and associated costs in us children after implementation of rotavirus vaccines rotavirus vaccines continue to reduce diarrhea hospitalizations medical costs in us kids stable peptide of the endogenous opioid enkephalin precursor and breast cancer risk anti stress hormone may provide indication of breast cancer risk bad metallic transport in a cold atom fermi hubbard system how unconventional metals behave with an eye on high temperature superconductors penetration of bomb c into the deepest ocean trench radioactive carbon from nuclear bomb tests found in deep ocean trenches somatic mutations reveal lineage relationships and age related mutagenesis in human hematopoiesis healthy blood stem cells have as many dna mutations as leukemic cells large cross national differences in gene x socioeconomic status interaction on intelligence in us poverty dampens genetic influence on iq multi layer graphene as a selective detector for future lung cancer biosensing platforms graphene biosensor could provide early lung cancer diagnosis braf inhibition stimulates melanoma associated macrophages to drive tumor growth macrophages may play critical role in melanoma resistance to braf inhibitors a computational framework for genome wide characterization of the human disease landscape tool reveals molecular causes of disease including infant cancer low diversity cryptococcus neoformans variety grubii multilocus sequence types from thailand are consistent with an ancestral african origin scientists track evolution and spread of deadly fungus one of the world s major killers genome wide kinase chromatin interactions reveal the regulatory network of erk signaling in human embryonic stem cells scientists discover molecular communication network in human stem cells biological and structural characterization of a host adapting amino acid in influenza h n flu virus used new biochemical trick to cause pandemic systematic review of the australian bush coconut genus cystococcus hemiptera eriococcidae uncovers a new species from queensland hiding in plain sight new insect species discovered in south east queensland australia ab initio molecular dynamics study of carbonation and hydrolysis reactions on cleaved quartz surface co mineralization in geologically common rocks for carbon storage tracking suicide risk factors through twitter in the us suicidal talk on twitter mirrors state suicide rates admission hematocrit predicts the need for transfusion secondary to hemorrhage in pediatric blunt trauma patients low cost blood test good predictor of increased bleeding risk in pediatric trauma patients statin use for the primary prevention of cardiovascular disease in adults recommendations regarding use of statins for the prevention of cardiovascular disease spray dried mesoporous mixed cu ni oxide graphene nanocomposite microspheres for high power and durable li ion battery anodes for a longer battery life pushing lithium ion batteries to the next performance level gamma ray showers observed at ground level in coincidence with downward lightning leaders breakthrough in understanding rare lightning triggered gamma rays higher temperatures increase suicide rates in the united states and mexico warming temperatures could increase suicide rates across the us and mexico resective epilepsy surgery for tuberous sclerosis in children for children with rare genetic disorder more extensive epilepsy surgery yields better seizure control elucidating the genetic basis of biomass accumulation and radiation use efficiency in spring wheat and its role in yield potential old for new using ancient genetic variation to supercharge wheat excess of rare variants in genes identified by genome wide association study of hypertriglyceridemia rare and common genetic variations responsible for high triglyceride levels in blood it s all good corporate social responsibility promotes positive response to service failures among value aligned customers does corporate social responsibility reduce negative reviews for bad service ? the presence of post traumatic stress disorder symptoms in adolescents three months after an magnitude earthquake in southwest china teenage girls and senior students suffered highest levels of ptsd after major earthquake study finds early infancy microbial and metabolic alterations affect risk of childhood asthma four gut bacteria decrease asthma risk in infants impact of the national health service health check on cardiovascular disease risk a difference in differences matching analysis uk health check has only modest impact on risk factors for cardiovascular disease ezh protects glioma stem cells from radiation induced cell death in a melk foxm dependent manner glioblastoma study ties three genes to radiation resistance in recurrent tumors emollient bath additives for the treatment of childhood eczema bathe multicentre pragmatic parallel group randomised controlled trial of clinical and cost effectiveness trial finds no benefit of bath emollients beyond standard eczema care for children association of ctnnb catenin alterations body mass index and physical activity with survival in patients with colorectal cancer activation of biomarker linked with improved survival among obese patients with colorectal cancer il driven stat signalling in senescent macrophages promotes pathological eye angiogenesis new clues found to vision loss in macular degeneration exploring the e cigarette e commerce marketplace identifying internet e cigarette marketing characteristics and regulatory gaps online e cigarette vendors engage customers using popular internet tools clonal evolution in breast cancer revealed by single nucleus genome sequencing same cancer different time zone cancer cells each grow at different speeds study shows recent violence in a community based sample of homeless and unstably housed women with high levels of psychiatric comorbidity high rates of violence suffered by unstably housed women in san francisco description and ecology of two new species of gyronotus van lansberge coleoptera scarabaeidae from southern africa the mysterious scarab beetles two new species of the endangered ancient genus gyronotus genome sequence of enterovirus d from st. louis missouri usa genome sequenced of enterovirus d circulating in st. louis maternal metabolic risk factors for autism spectrum disorder an analysis of electronic medical records and linked birth data study strengthens evidence linking autism to maternal obesity diabetes effects of acupuncture ru on the hypothalamic pituitary adrenal axis in chronically stressed adult male rats acupuncture impacts same biologic pathways in rats that pain drugs target in humans combined toxicity of insecticides and fungicides applied to california almond orchards to honey bee larvae and adults culprit found for honeybee deaths in california almond groves knowing what it makes how product transformation salience increases recycling people recycle more when they know what recyclable waste becomes laminin receptor specific therapeutic gold nanoparticles aunp egcg show efficacy in treating prostate cancer gold nanoparticles could treat prostate cancer with fewer side effects than chemotherapy saturnispora quitensis sp. nov. a yeast species isolated from the maquipucuna cloud forest reserve in ecuador maquipucuna cloud forest in ecuador yields new species of yeast adaptive significance of arboreality field evidence from a tree climbing land snail scientists go out on a limb to study tree climbing land snails the nerve of ovulation inducing factor in semen sex and the female brain protein in semen acts on female brain to prompt ovulation clonal hematopoiesis associated with tet deficiency accelerates atherosclerosis development in mice a role for mutated blood cells in heart disease ? racial disparities in discontinuation of long term opioid therapy following illicit drug use among black and white patients racial disparities in prescribing opioids for chronic pain smn deficiency alters nrxn expression and splicing in zebrafish and mouse models of spinal muscular atrophy scientists provide new insights into cause of human neurodegenerative disease patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria bacteria play critical role in driving colon cancers increasing influence of air temperature on upper colorado river streamflow colorado river flows reduced by warmer spring temperatures developmental pathway for potent v v directed hiv neutralizing antibodies potent hiv antibody research has opened up possibilities for hiv prevention treatment future ocean hypercapnia driven by anthropogenic amplification of the natural co cycle rising carbon dioxide emissions pose intoxication threat to world s ocean fish polystichum munitum dryopteridaceae varies geographically in its capacity to absorb fog water by foliar uptake within the redwood forest ecosystem redwood forest ecosystem of northern california depends on fog to stay hydrated during rainless summers pseudo projection approach to reconstruct locations of point like scatterers characterized by lam parameters and mass densities in an elastic half space a novel method for improving imaging techniques in geophysical and material studies evidence of hippocampal structural alterations in gulf war veterans with predicted exposure to the khamisiyah plume khamisiyah plume linked to brain and memory effects in gulf war vets understanding the origins of bacterial resistance to aminoglycosides through molecular dynamics mutational study of the ribosomal a site computer simulations aid understanding of bacterial resistance against commonly used antibiotics discovery of rr lyrae stars in the nuclear bulge of the milky way the milky way s ancient heart vista finds remains of archaic globular star cluster screening for intimate partner violence in health care settings a randomized trial universal screening for intimate partner violence may provide only modest benefits the search for failed supernovae with the large binocular telescope constraints from yr of data the big star that couldn t become a supernova restoration of corneal transparency by mesenchymal stem cells researchers shed light on repair mechanism for severe corneal injuries hoxa determines cell fate transition and impedes tumor initiation and progression in breast cancer through regulation of e cadherin and cd hoxa protein acts as tumor suppressor in breast cancer lab cell study shows climate impacts on global hot spots of marine biodiversity hot spots of marine biodiversity most severely impacted by global warming pigs unlike mice have two distinct colonic stem cell populations similar to humans that respond to high calorie diet prior to insulin resistance using a pig model to study chronic diseases may help minimize drug failure rate acne is not associated with yet uncultured bacteria new study claims acne is not associated with yet uncultured bacteria reading with sounds sensory substitution selectively activates the visual word form area in the blind activating the mind s eye alternative vision using sounds the relationship between end of treatment alcohol use and subsequent healthcare costs do heavy drinking days predict higher healthcare costs ? using heavy drinking days to measure treatment effectiveness recognition of synthetic glycopeptides by hiv broadly neutralizing antibodies and their unmutated ancestors new artificial protein mimics part of hiv outer coat sources of radium accumulation in stream sediments near disposal sites in pennsylvania implications for disposal of conventional oil and gas wastewater radioactivity from oil and gas wastewater persists in pennsylvania stream sediments the effect of green exercise on blood pressure heart rate and mood state in primary school children health benefits of green exercise for kids shown in new study rare coding variants in plcg abi and trem implicate microglial mediated innate immunity in alzheimer s disease newly discovered gene variants link innate immunity and alzheimer s disease genomic adaptations of the halophilic dead sea filamentous fungus eurotium rubrum salt needed tolerance lessons from a dead sea fungus synchrony is more than its top down and climatic parts interacting moran effects on phytoplankton in british seas novel methodological tool helps detect synergistic phenomena in phytoplankton growth perinatal exposure to an environmentally relevant mixture of phthalates results in a lower number of neurons and synapses in the medial prefrontal cortex and decreased cognitive flexibility in adult male and female rats plastic chemical linked to smaller prefrontal cortex reduced cognitive ability in rats efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in china folic acid supplementation among adults with hypertension reduces risk of stroke malignant melanoma associated with chronic once daily aspirin exposure in males a large single center urban u.s. patient population cohort study from the research on adverse drug events and reports radar project daily aspirin linked to double melanoma risk in men accounting for multiple foundation species in oyster reef restoration benefits study puts some mussels into chesapeake bay restoration specificity in etiology of subtypes of bipolar disorder evidence from a swedish population based family study family study emphasizes distinct origins for bipolar disorder subtypes bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in alzheimer s disease different brain atrophy patterns may explain variability in alzheimers disease symptoms mechanoresponsive stem cells to target cancer metastases through biophysical cues stem cell therapy attacks cancer by targeting unique tissue stiffness plant sterols the better cholesterol in alzheimer s disease ? a mechanistical study preventive effect of plant sterols in alzheimer s disease streptococcal m protein triggers chemokine formation neutrophil infiltration and lung injury in an nfat dependent manner scientists discover protein that plays key role in streptococcal infections immune responsive resolvin d programs myocardial infarction induced cardiorenal syndrome in heart failure resolvin d limits kidney damage after heart attacks relation of late life social activity with incident disability among community dwelling older adults higher levels of social activity decrease the risk of developing disability in old age differential effects of daily moderate versus weekend binge alcohol consumption on atherosclerotic plaque development in mice drinking pattern linked to alcohol s effect on heart health discovery of a biomarker and lead small molecules to target r ggggcc associated defects in c ftd als researchers develop strategy to combat genetic als ftd krebs cycle deficient hereditary cancer syndromes are defined by defects in homologous recombination dna repair cancer researchers suggest new treatment for rare inherited cancers residual stress preserved in quartz from the san andreas fault observatory at depth a new level of earthquake understanding surprise findings from san andreas fault rock sample timely digital patient clinician communication in specialist clinical services for young people a mixed methods study the lync study digital communication improves young patient engagement according to new study hearing aid use is associated with better mini mental state exam performance hearing aid use is associated with improved cognitive function in hearing impaired elderly areas of the brain modulated by single dose methylphenidate treatment in youth with adhd during task based fmri a systematic review methylphenidate normalizes activation in key brain areas in kids with adhd study suggests reef sharks exhibit site fidelity and higher relative abundance in marine reserves on the mesoamerican barrier reef counting reef sharks with cameras chum cam underwater video survey shows that reef sharks thrive in marine reserves ecophysiological examination of the lake erie microcystis bloom in linkages between biology and the water supply shutdown of toledo ohio virus infection may be linked to toledo water crisis study shows interaction of fixed number of photons with retinal rod cells the seeing power of frogs frogs can detect single photons of light dynamic responses of the adrenal steroidogenic regulatory network adrenal gland activity changes under severe stress causing abnormal release of glucocorticoid stress of mice men and trolleys hypothetical judgment versus real life behavior in trolley style moral dilemmas people make different moral choices in imagined versus real life situations physiological plasticity increases resilience of ectothermic animals to climate change how pace of climate change will challenge ectotherms intervention to influence behaviors linked to risk of chronic diseases a multisite randomized controlled trial with african american hiv serodiscordant heterosexual couples study tests interventions targeting multiple health related behaviors in african american couples hurricane mar a tripled stem breaks and doubled tree mortality relative to other major storms hurricane maria study warns future climate driven storms may raze many tropical forests hair follicle targeting penetration enhancement and langerhans cell activation make cyanoacrylate skin surface stripping a promising delivery technique for transcutaneous immunization with large molecules and particle based vaccines needle free vaccination how scientists ask skin cells for help prevalence of cervical disease at age after immunisation with bivalent hpv vaccine at age in scotland retrospective population study routine hpv vaccination linked to dramatic reduction in cervical disease among young women neural preservation underlies speech improvement from auditory deprivation in young cochlear implant recipients brain imaging predicts language learning in deaf children the treatment cascade for chronic hepatitis c virus infection in the united states a systematic review and meta analysis major gaps in hepatitis c care identified as new drugs screening efforts emerge afadin and rhoa control pancreatic endocrine mass via lumen morphogenesis study reveals endocrine producing microenvironment in embryonic pancreas pvc flooring is related to human uptake of phthalates in infants phthalates in pvc floors taken up by the body in infants cost of near roadway and regional air pollution attributable childhood asthma in los angeles county childhood asthma due to living near major roadways cost los angeles residents million in whole cell biosynthesis of a functional oligosaccharide fucosyllactose using engineered escherichia coli metabolic engineer synthesizes key breast milk ingredient sugar in human milk may protect babies from pathogens assembly and validation of the genome of the nonmodel basal angiosperm amborella the origin of flowers dna of storied plant provides insight into the evolution of flowering plants time course of episodes of definitive vertigo in meniere s disease time surgery appear to reduce episodes of dizziness in patients with m ni re s disease food allergic adolescents at risk for anaphylaxis a randomized controlled study of supervised injection to improve comfort with epinephrine self injection supervised self injection with empty syringes improved comfort in food allergic adolescents administering epinephrine study finds neural control of body plan axis in regenerating planaria scientists unlock new role for nervous system in regeneration population genetic structure of gray wolves canis lupus in a marine archipelago suggests island mainland differentiation consistent with dietary niche wolves in wolves clothing not all the same surprising distinction between mainland coastal wolves in b.c. low frequency magnetic fields do not aggravate disease in mouse models of alzheimer s disease and amyotrophic lateral sclerosis no evidence that low frequency magnetic fields accelerate development of alzheimer s disease and als sickness absence diagnoses among abstainers low risk drinkers and at risk drinkers consideration of the u shaped association between alcohol use and sickness absence in four cohort studies study examines sickness absence from work among abstainers low risk drinkers and at risk drinkers near road air pollutant measurements accounting for inter site variability using emission factors large trucks are biggest culprits of near road air pollution rapid detection of internalizing diagnosis in young children enabled by wearable sensors and machine learning wearable sensor can detect hidden anxiety depression in young children widespread episodic thiamine deficiency in northern hemisphere wildlife salmon blue mussel eider and eel die from the same vitamin deficiency the effects of habitat climate and barred owls on long term demography of northern spotted owls northern spotted owl decline linked to invasive owl habitat loss and climate potential enthalpic energy of water in oils exploited to control supramolecular structure lone water molecules turn out to be directors of supramolecular chemistry ongoing transposon mediated genome reduction in the luminous bacterial symbionts of deep sea ceratioid anglerfishes glowing bacteria on deep sea fish shed light on evolution third type of symbiosis geranylgeraniol suppresses the viability of human du prostate carcinoma cells and the level of hmg coa reductase plant oil suppresses viability of human prostate cancer cells gait speed and operative mortality in older adults following cardiac surgery walking ability predictor of adverse outcomes following cardiac surgery effects of long term treatment with estrogen and medroxyprogesterone acetate on synapse number in the medial prefrontal cortex of aged female rats long term hormone treatment increases synapses in female rats prefrontal cortex vessel sparing radiation and functional anatomy based preservation for erectile function after prostate radiotherapy quality of life meets cure for prostate cancer treatment depressive symptoms before and after treatment of obstructive sleep apnea in men and women cpap therapy reduces symptoms of depression in adults with sleep apnea aa a xenograft model of er breast adenocarcinoma new weapon in fight against breast cancer new mouse model thalamic alterations in preterm neonates and their relation to ventral striatum disturbances revealed by a combined shape and pose analysis brain changes linked to prematurity may explain risk of neurodevelopmental disorders the reacceleration of the shock wave in the radio remnant of sn a thirty years in the life of supernova a prevalence underlying causes and preventability of sepsis associated mortality in us acute care hospitals sepsis a leading cause of death in us hospitals but many deaths may not be preventable piezoelectric sensors to monitor lubricant film thickness at piston cylinder contacts in a fired engine ultrasound can now monitor the health of your car engine targeting bacterial adherence inhibits multidrug resistant pseudomonas aeruginosa infection following burn injury study identifies a way to prevent burn injury infection without antibiotics origin and evolution of a splay fault in the nankai accretionary wedge ocean drilling expedition cites new evidence related to origin and evolution of seismogenic faults gambling and sexual behaviors in african american adolescents risky behaviors of gambling sex linked in african american youth the assassination of robert f. kennedy an analysis of the senator s injuries and neurosurgical care rfk s assassination a medical analysis of his injuries and neurosurgical care fetal microchimerism and maternal health a review and evolutionary analysis of cooperation and conflict beyond the womb the alien within fetal cells influence maternal health during pregnancy and long after family meals can help children reach their a day a cross sectional survey of children s dietary intake from london primary schools occasional family meals enough to boost kids fruit and veg intake connecting clinical aspects to corticomotor excitability in restless legs syndrome a tms study restless legs syndrome brain stimulation study supports motor cortex excitability as a cause molecular and behavioral responses of early life stage fishes to elevated carbon dioxide research using carbon dioxide keeps even small fry invasive carp at bay network biology discovers pathogen contact points in host protein protein interactomes network biology reveals pathogen targets in the model plant arabidopsis thaliana mecp binds to non cg methylated dna as neurons mature influencing transcription and the timing of onset for rett syndrome mystery of rett timing explained in mecp binding self management of anticoagulant therapy in mechanical heart valve patients a matched cohort study heart valve patients may benefit from managing own blood thinners increase in cfc emissions from eastern china based on atmospheric observations scientists discover the source of new cfc emissions marine teleost locates live prey through ph sensing unique way that catfish locate prey whiskers detect slight changes in ph particle shape enhances specificity of antibody displaying nanoparticles changing shape makes chemotherapy drugs better at targeting cancer cells maximum rates of climate change are systematically underestimated in the geological record idea of slow climate change in earth s past misleading antibiotic induced alterations of the murine gut microbiota and subsequent effects on colonization resistance against clostridium difficile multiple co existing groups of gut bacteria keep clostridium difficile infections at bay adaptation to a spouse s disability by parents of adult children with mental illness or developmental disability impact of caring for adult child with disability studied e cigarettes generate high levels of aldehydes only in dry puff conditions new study challenges claims on aldehyde content of third generation e cigarettes vitamins e and c in the prevention of cardiovascular disease in men vitamins e and c supplements not effective for prevention of cardiovascular disease in men lack of sprouty and enhances survival of effector cd t cells and yields more protective memory cells two molecules offer great potential to combat cancer and chronic infections national high school athlete concussion rates from to concussion rate in high school athletes more than doubled in year period u.s. study finds in vivo labeling by cd marks multipotent stromal cells and highlights endothelial heterogeneity in the bone marrow niche new mouse model makes stem cells light up green essential in vivo roles of the c type lectin receptor clec embryonic neonatal lethality of clec deficient mice by blood lymphatic misconnections and impaired thrombus formation of clec deficient platelets snake venom studies yield insights for development of therapies for heart disease and cancer visible light photocatalytic degradation of microplastic residues with zinc oxide nanorods innovative nanocoating technology harnesses sunlight to degrade microplastics a hardware based modeling approach for real world collaborative multi robot tasks novel hardware based modeling approach for multi robot tasks generation of shape complexity through tissue conflict resolution why plant tissues have a sense of direction examination of the effects of an intervention aiming to link patients receiving addiction treatment with health care the linkage clinical trial empowering addiction treatment patients to engage in care may improve overall health five new species of syzygium myrtaceae from sulawesi indonesia year records gap on sulawesi ends with five new species in the world s largest tree genus living with own or husband s mother in the household is associated with lower number of children a cross cultural analysis household with mother in law means fewer kids fresh fruit consumption and major cardiovascular disease in china fresh fruit associated with lower risk of heart attack and stroke molecular evolution of broadly neutralizing llama antibodies to the cd binding site of hiv how llamas unusual antibodies might help in the fight against hiv aids implementation of lung cancer screening in the veterans health administration report describes vha clinical demonstration project for lung cancer screening effects of changes in lunch time competitive foods nutrition practices and nutrition policies on low income middle school children s diets schools help kids choose carrots over candy bars caution is needed in operating and managing the waste of new pebble bed nuclear reactors experts voice safety concerns about new pebble bed nuclear reactors experimental evidence supports a sex specific selective sieve in mitochondrial genome evolution research breakthrough on male infertility small set of genes in cells mitochondria are key translaminar cortical membrane potential synchrony in behaving mice wiretapping the senses scientists monitor conversation between sensory perception behavior in the mouse brain guidance of super enhancers in regulation of il induction and airway inflammation new explanation for why airways close in asthma holds promise for future class of drugs unprecedented st century drought risk in the american southwest and central plains warming pushes western u.s. toward driest period in years unprecedented risk of drought in st century phase controlled coherent dynamics of a single spin under closed contour interaction novel approach to coherent control of a three level quantum system broadband light management with thermochromic hydrogel microparticles for smart windows see through film rejects percent of incoming solar heat determination of the impact of melanoma surgical timing on survival using the national cancer database timing of melanoma diagnosis treatment critical to survival an elaborate heterotrimeric g protein family from soybean expands the diversity of plant g protein networks discovery identifies elaborate g protein network in plants the impact of restructuring on employee well being a systematic review of longitudinal studies restructuring affects staff well being regardless of job cuts drug screening for als using patient specific induced pluripotent stem cells anacardic acid found to rescue certain als abnormalities in experimental drug screening assay using motor neurons from als patient specific ipscs interactive effects of mosquito control insecticide toxicity hypoxia and increased carbon dioxide on larval and juvenile eastern oysters and hard clams mosquito control pesticide use in coastal areas poses low risk to juvenile oysters hard clams computer vision uncovers predictors of physical urban change computer vision algorithm used to study google street view images for signs of urban change light patterned current generation in a droplet bilayer array student creates first synthetic retina for the visually impaired intimate partner violence and new onset depression a longitudinal study of women s childhood and adult histories of abuse impact of domestic violence on women s mental health the relationship of three dimensional human skull motion to brain tissue deformation in magnetic resonance elastography studies studying the brain s suspension system in tbis selective laminin directed differentiation of human induced pluripotent stem cells into distinct ocular lineages eye opening study differentiates ips cells into various ocular lineages h d hfe genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis genotype found in percent of als patients speeds up disease progression acc aha guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults new guideline for management of blood cholesterol focuses on lifestyle statin therapy for patients who most benefit gene therapy prolongs survival and restores function in murine and canine models of myotubular myopathy gene therapy leads to robust improvements in animal model of fatal muscle disease colistin and carbapenem resistant escherichia coli harboring mcr and blandm causing a complicated urinary tract infection in a patient from the united states researchers identify multidrug resistant e. coli bacteria from new jersey patient single cell transcriptomics analyses of neural stem cell heterogeneity and contextual plasticity in a zebrafish brain model of amyloid toxicity how fish brain cells react to alzheimer s disease multi year drought induced morbidity preceding tree death in southeastern us forests drought implicated in slow death of trees in southeast s forests early childhood conduct problems predict economic and political discontent in adulthood evidence from two large longitudinal uk cohorts adults political leanings linked with early personality traits brain development in children with new onset epilepsy a prospective controlled cohort investigation altered brain development found in children with newly diagnosed epilepsy a population of faint low surface brightness galaxies in the perseus cluster core trace of galaxies at the heart of a gigantic galaxy cluster are armchair socialists still sitting ? cross sectional study of political affiliation and physical activity political leanings and time spent sitting around left wing armchair socialists more physically active than political centrists randomized controlled double blinded field trial to assess leishmania vaccine effectiveness as immunotherapy for canine leishmaniosis treatment for canine leishmaniasis exists in brazilian vaccine a cost effectiveness tool to guide the prioritization of interventions for rheumatic fever and rheumatic heart disease control in african nations new tool to determine cost effective control of rheumatic heart disease bartonellaspp. bacteremia and rheumatic symptoms in patients from lyme disease endemic region bartonella infection associated with rheumatoid illnesses in humans finishing bedding plants a comparison of an unheated high tunnel versus a heated greenhouse in two geographic locations high tunnels found effective for finishing cold tolerant annuals tdap vaccination during pregnancy and microcephaly and other structural birth defects in offspring no association found between tdap vaccination during pregnancy microcephaly structural birth the foxm inhibitor rcm suppresses goblet cell metaplasia and prevents il and stat signaling in allergen exposed mice experimental drug targets nucleus of allergen sensitized cells neuraminidase mediated nkp dependent immune evasion mechanism of influenza viruses boosting body s natural flu killers as way to offset virus mutation problem structural insights into modulation of neurexin neuroligin trans synaptic adhesion by mdga neuroligin complex structural insights into the modulation of synaptic adhesion by mdga for synaptogenesis occurrence and family impact of elopement in children with autism spectrum disorders nearly half of children with autism wander or bolt from safe places building two dimensional materials one row at a time avoiding the nucleation barrier two dimensional materials skip the energy barrier by growing one row at a time proteophosophoglycans regurgitated by leishmania infected sand flies target the l arginine metabolism of host macrophages to promote parasite survival parasites persuade immune cells to invite them in for dinner a multicomponent school based intervention the shaping healthy choices program improves nutrition related outcomes garden enhanced intervention improved bmi nutrition knowledge of california students a gene specific role for the ssu rnapii ctd phosphatase in hiv tat transactivation new dent in hiv s armor promising target for hiv aids treatment identification of genetic factors that modify clinical onset of huntington s disease scientists adopt new strategy to find huntington s disease therapies engineering oxygen containing and amino groups into two dimensional atomically thin porous polymeric carbon nitrogen for enhanced photocatalytic hydrogen production solar to hydrogen conversion nanostructuring increases efficiency of metal free photocatalysts by factor use of online communication by patients with newly diagnosed breast cancer during the treatment decision process social media linked to more satisfaction with breast cancer treatment decisions long term relationships between ocean variability and water resources in northeastern utah ocean conditions likely to reduce colorado river flows during this winter s drought associations between alteration in plant phenology and hay fever prevalence among us adults implication for changing climate changes in onset of spring linked to more allergies across the us design and synthesis of a mao b selectively activated prodrug based on mptp a mitochondria targeting chemotherapeutic agent for treatment of human malignant gliomas brain tumor cells decimated by mitochondrial smart bomb digested formula but not digested fresh human milk causes death of intestinal cells in vitro implications for necrotizing enterocolitis digested formula but not breast milk is toxic to cells in vitro study finds extensive amazonian aged fluvial channels on mars evaluating the role of lyot crater in their formation hot rocks not warm atmosphere led to relatively recent water carved valleys on mars yak dung combustion aerosols in the tibetan plateau chemical characteristics and influence on the local atmospheric environment climate change deteriorates water quality in the himalayas affecting of world s population cancer specific mortality of asian americans diagnosed with cancer a nationwide population based assessment new insights into survival outcomes of asian americans diagnosed with cancer the genetic landscape of the childhood cancer medulloblastoma genome code cracked for most common form of pediatric brain cancer ancient proteins from ceramic vessels at atalh y k west reveal the hidden cuisine of early farmers cuisine of early farmers revealed by analysis of proteins in pottery from atalh y k mammography screening among the elderly a research challenge benefits of regular mammography extend to the elderly study suggests a neuromorphic network for generic multivariate data classification computing with silicon neurons scientists use artificial nerve cells to classify different types of data ephrin b controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration essential genetic mechanism of cerebral cortex development discovered performance and prospects of payments for ecosystem services programs evidence from china environmental policy tallying the wins and losses of policy induction of telomere dysfunction prolongs disease control of therapy resistant melanoma targeting telomeres to overcome therapy resistance in advanced melanoma collaborative care outcomes for pediatric behavioral health problems a cluster randomized trial integrating mental health services in pediatric practices feasible effective study finds north atlantic warming during dansgaard oeschger events synchronous with antarctic warming and out of phase with greenland climate ice age blob of warm ocean water discovered south of greenland global regional and national incidence prevalence and years lived with disability for acute and chronic diseases and injuries in countries a systematic analysis for the global burden of disease study as death rates drop nonfatal diseases and injuries take a bigger toll on health globally sleep disordered breathing and pro thrombotic biomarkers cross sectional results of the cleveland family study possible link between sleep disordered breathing and cardiovascular disease revealed decapod fauna of the helgoland trench crustacea a long term study in a biodiversity hotspot climate change in the north sea long term studies reveal drastic changes in the marine fauna sleep patterns and problems among early adolescents associations with alcohol use insomnia linked to alcohol use among adolescents study shows recurrent intragenic rearrangements of egfr and braf in soft tissue tumors of infants genomics offers new treatment options for infants with range of soft tissue tumors bird monitoring in europe a first overview of practices motivations and aims ecological monitoring on bird populations in europe re evaluated does playing violent video games cause aggression ? a longitudinal intervention study daily dose of violent video games has no long term effect on adult aggression researchers find can functional nasal surgery treat chronic headaches ? a systematic review functional nasal surgery relieves chronic headache for some patients possible association between obesity and clostridium difficile infection obesity may increase risk of clostridium difficile infection a retrospective summary of raptor mortality in ontario canada including the effects of west nile virus humans behind majority of raptor deaths in ontario canada adnp nap dramatically increase microtubule end binding protein tau interaction a novel avenue for protection against tauopathy drug candidate stabilizes essential transport mechanism in nerve cells cost effectiveness of hepatitis c treatment using generic direct acting antivirals available in india costs for generic hepatitis c drugs available in india would be paid back in to years coexistent sickle cell disease has no impact on the safety or outcome of lytic therapy in acute ischemic stroke first systemic evidence for safety of tpa in stroke patients with sickle cell disease super cationic carbon quantum dots synthesized from spermidine as an eye drop formulation for topical treatment of bacterial keratitis quantum dots make the leap from tvs to antibacterial eye drops outpatient pharmacy expenditures for children with serious chronic illness in california pharmacy expenditures for children with serious chronic illness topoisomerase inhibition suppresses inflammatory genes and protects from death by inflammation researchers discover potential treatment for sepsis and other responses to infection a qualitative study of successful adolescent and young adult weight losers implications for weight control intervention overweight teens lose weight for the right reasons study shows phosphoglycerate mutase regulates dntp pool and promotes homologous recombination repair in cancer cells murine study finds potential boost for ovarian cancer drug olaparib vitamin d with calcium reduces mortality patient level pooled analysis of patients from eight major vitamin d trials vitamin d with calcium shown to reduce mortality in elderly cryptic glucocorticoid receptor binding sites pervade genomic nf b response elements duel of the inflammatory master regulators insights for drug discovery dengue vaccines regulatory pathways a report on two meetings with regulators of developing countries capacity of developing country nras key to accelerated introduction of upcoming dengue vaccines synaptic inputs from stroke injured brain to grafted human stem cell derived neurons activated by sensory stimuli transplanted neurons incorporated into a stroke injured rat brain pharmacologic and mechanical strategies for preventing venous thromboembolism after bariatric surgery a systematic review and meta analysis temporary blood clot filters may do more harm than good for bariatric surgery patients psychological processes mediate the impact of familial risk social circumstances and life events on mental health traumatic life events biggest cause of anxiety depression mind matters placebo enhances reward learning in parkinson s disease mere expectation of treatment can improve brain activity in parkinson s patients metabolic adaptation to nutritional stress in human colorectal cancer the importance of the glutamine metabolism in colon cancer replacement bisphenols adversely affect mouse gametogenesis with consequences for subsequent generations bpa replacements in plastics cause reproductive problems in lab mice analysis of mammalian gene function through broad based phenotypic screens across a consortium of mouse clinics role of genes in disease revealed in major european mouse study men s experience of erectile dysfunction after treatment for colorectal cancer qualitative interview study male bowel cancer patients need more information about erectile dysfunction experts say age related changes in the plasticity and toughness of human cortical bone at multiple length scales the brittleness of aging bones more than loss of bone mass changes in alcohol related brain networks across the first year of college a prospective pilot study using fmri effective connectivity mapping brain mapping increases understanding of alcohol s effects on first year college students maternal exposure to ambient particulate matter. m during pregnancy and the risk for high blood pressure in childhood in womb air pollution exposure associated with higher blood pressure in childhood hearing loss in older adults affects neural systems supporting speech comprehension mild hearing loss linked to brain atrophy in older adults early intervention could prevent slide toward speech comprehension difficulties disease ecology across soil boundaries effects of below ground fungi on above ground host parasite interactions four biological kingdoms influence disease transmission in monarch butterflies endocrine therapy resistant esr variants revealed by genomic characterization of breast cancer derived xenografts new models of drug resistant breast cancer hint at better treatments positive parenting and early puberty in girls protective effects against aggressive behavior positive parenting associated with less aggression in early maturing teen girls the consequences of tobacco tax on household health and finances in rich and poor smokers in china an extended cost effectiveness analysis experts call for a tobacco free world by ectopic expression of the striatal enriched gtpase rhes elicits cerebellar degeneration and an ataxia phenotype in huntington s disease study points to drug target for huntington s disease change in high density lipoprotein cholesterol and risk of subsequent hospitalization for coronary artery disease or stroke among patients with type diabetes mellitus raising good cholesterol levels reduces heart attack and stroke risk in diabetes patients avian migrants facilitate invasions of neotropical ticks and tick borne pathogens into the united states pathogen carrying neotropical ticks ride migratory birds into us perinatal complications are associated with social anxiety indirect effects through temperament complications during birth and later social anxiety in children environmental manganese and cancer mortality rates by county in north carolina an ecological study environmental manganese good in trace amounts but can correlate to cancer rates in plane heterostructures of graphene and hexagonal boron nitride with controlled domain sizes toward d devices single atom thick patterns combine conductor and insulator effect of age on response to amblyopia treatment in children younger age associated with greater treatment response in children with amblyopia tanning and increased nevus development in very light skinned children without red hair tanning may be associated with moles in very light skinned children ccnd cdk mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo blood stem cells in a rush velocity determines quality childhood maltreatment and unfavourable clinical outcomes in bipolar disorder a systematic review and meta analysis childhood maltreatment predicts range of negative outcomes in bipolar patients effects of arterial stiffness on brain integrity in young adults from the framingham heart study vascular brain injury evident in people in their s shoot to root mobile polypeptides involved in systemic regulation of nitrogen acquisition nitrogen foraging ability of plants relies on mobile shoot root hormone signal a novel sero genetic approach determines the community prevalence of celiac disease and informs improved diagnostic pathways new approach to celiac testing identifies more at risk quantitative high throughput screening identifies cytoprotective molecules that enhance sumo conjugationviathe inhibition of sumo specific protease senp hibernating ground squirrels provide clues to new stroke treatments lethal means restriction for suicide prevention beliefs and behaviors of emergency department providers many emergency department providers don t ask suicidal patients about gun access circumscribed non diffuse histology confers a better prognosis in h k m mutant gliomas dipg tumor patterns offer new insight on survival fertility rate trends among adolescent girls with major mental illness a population based study study finds three fold increase in pregnancy among young girls with mental illness cross modulation of pathogen specific pathways enhances malnutrition during enteric co infection with giardia lamblia and enteroaggregative escherichia coli co infection with two common gut pathogens worsens malnutrition in mice the sounds of silence inferences from the absence of word of mouth potential flaw in our assumptions about unknown opinions of others efficacy and biomarker study of bevacizumab for hearing loss resulting from neurofibromatosis type associated vestibular schwannomas anticancer drug restores hearing in some patients with neurofibromatosis long term decline of the western pacific leatherback dermochelys coriacea a globally important sea turtle population leatherback sea turtle could be extinct within years at last stronghold in the pacific ocean genetic loss of faah compromises male fertility in mice bliss blocks sperm investigating impact of marijuana exposure on male infertility a pharmacist led medication assessment used to determine a more precise estimation of the prevalence of complementary and alternative medication cam use among ambulatory senior adults with cancer high use of alternative medicine in senior oncology patients expression of hypoxia inducible factor predicts benefit from hypoxia modification in invasive bladder cancer bladder cancer patients identified who could benefit from tumor softening treatment magnetic vestibular stimulation in subjects with unilateral labyrinthine disorders potential use of mri magnetic fields to diagnose treat balance disorders dizziness imaging blood brain barrier dysfunction in football players football players found to have brain damage from mild unreported concussions brown adipose tissue controls skeletal muscle function via the secretion of myostatin new light shed on relationship between calorie burning fat and muscle function impact of climate change on the transition of neanderthals to modern humans in europe cold climates contributed to the extinction of the neanderthals selective serotonin reuptake inhibitor ssri antidepressants in pregnancy and congenital anomalies analysis of linked databases in wales norway and funen denmark link found between antidepressant use and congenital anomalies or stillbirths herbaceous layer response to years of controlled deer hunting in forested natural areas hunting gives deer damaged forests in state parks a shot at recovery an approach to physical rehabilitation using state of the art virtual reality and motion tracking technologies virtual reality for motor rehabilitation of the shoulder against all odds genocidal trauma is associated with longer life expectancy of the survivors against all odds male holocaust survivors have a longer life expectancy hsv exploits the innate immune scavenger receptor marco to enhance epithelial adsorption and infection herpes virus exploits immune response to bolster infection migrating birds reorient toward land at dawn over the great lakes usa migrating birds pile up along great lakes shores reduced amino acids in the bovine uterine lumen of cloned versusin vitrofertilized pregnancies prior to implantation inadequate supply of protein building blocks may explain pregnancy failures in bovine cloning experiments comprehensive molecular portraits of invasive lobular breast cancer breast cancer genomic analysis reveals invasive lobular carcinoma subtypes eye blinks are perceived as communicative signals in human face to face interaction length of eye blinks might act as conversational cue psychosis with methylphenidate or amphetamine in patients with adhd big data study identifies drugs that increase risk of psychosis in youth with adhd defining the earliest step of cardiovascular lineage segregation by single cell rna seq from stem cells to a functional heart the role of the mesp gene violent video games cause an increase in aggression long after the game has been turned off violent video games increase aggression long after the game is turned off study finds the quick dementia rating system qdrs a rapid dementia staging tool. new rapid dementia screening tool rivals gold standard clinical evaluations going green and cold biosurfactants from low temperature environments to biotechnology applications biotechnologists look to bacteria in extremely cold environments for green detergents common and costly hospitalizations for pediatric mental health disorders study identifies most common costly reasons for mental health hospitalizations for kids hormone therapy dose formulation route of delivery and risk of cardiovascular events in women hormone therapy formulations may pose varying risks for heart attack and stroke connectivity of tiger panthera tigris populations in the human influenced forest mosaic of central india presence of human settlements has negative impact on tiger connectivity molecular data reveal complex hybridization and a cryptic species of neotropical wild cat cryptic new species of wild cat identified in brazil best management practices for summer fallow in the world s driest rainfed wheat region conserving soil water in world s driest wheat region parental overprotection and heart focused anxiety in adults with congenital heart disease overprotective parents may impact heart anxiety in adults with congenital heart conditions metaproteomics of a gutless marine worm and its symbiotic microbial community reveal unusual pathways for carbon and energy use a toxic menu marine worm feeds on carbon monoxide and hydrogen sulphide with the help of symbiotic bacteria are empowered employees more proactive ? the contingency of how they evaluate their leader empowered employees are more proactive... even when they don t trust their leader an aedes aegypti associated fungus increases susceptibility to dengue virus by modulating gut trypsin activity common fungus helps dengue virus thrive in mosquitoes correlation analysis of symmetry breaking in the surface nanostructure ordering case study of the ventral scale of the snake morelia viridis perfect imperfection researchers develop method for cross species comparison of biological surfaces crystal structure of hiv tat complexed with human p tefb insight into structure of hiv protein could aid drug design a high quality carrot genome assembly provides new insights into carotenoid accumulation and asterid genome evolution carrot genome paints picture of domestication could help improve crops negative symptoms in schizophrenia a study in a large clinical sample of patients using a novel automated method negative symptoms of schizophrenia linked to poor clinical outcomes a year new england temperature reconstruction from in situ seasonally produced branched glycerol dialkyl glycerol tetraethers brgdgts geoscientists reconstruct eye opening year northeastern u.s. climate record improvement in social competence using a randomized trial of a theatre intervention for children with autism spectrum disorder children with autism benefit from theatre based program prevalence of persistent pain in the u.s. adult population new data from the national health interview survey persistent pain estimated in percent of u.s. adults discovery of insect and human dengue virus host factors new understanding of dengue virus points way to possible therapies for dengue fever pathways to elaboration of sexual dimorphism in bird plumage patterns evolution of plumage patterns in male and female birds a new historical inscription of sargon ii from karkemish mesopotamian king sargon ii envisioned ancient city karkemish as western assyrian capital gender equity in college majors looking beyond the stem non stem dichotomy for answers regarding female participation perceived gender bias against women is dominant factor in college major choice improving social engagement and initiations between children with autism spectrum disorder and their peers in inclusive settings autism researchers find that focusing on strengths improves social skills of adolescents thyroid status quality of life and mental health in patients on hemodialysis poor thyroid function may affect dialysis patients quality of life and daily living the kidney as a reservoir for hiv after renal transplantation hiv can infect transplanted kidneys in hiv positive recipients with undetectable virus ergodic dynamics and thermalization in an isolated quantum system physicists blur the line between classical and quantum physics by connecting chaos and entanglement program specific cost effectiveness analysis breast cancer screening policies for a safety net program cost effectiveness analysis applied to state breast cancer screening program childhood methylphenidate adherence as a predictor of antidepressants use during adolescence childhood methylphenidate treatment predicts antidepressant use during adolescence powerful multifunctional torsional micromuscles activated by phase transition a micro muscular breakthrough powerful new microscale torsional muscle motor from vanadium dioxide initial treatment for non syndromic early life epilepsy an unexpected consensus despite lack of efficacy data surprising consensus in pediatric anti epilepsy med scripts new dental composites containing multimethacrylate derivatives of bile acids a comparative study with commercial monomers stronger material for filling dental cavities has ingredients from human body declining breeding populations of white naped cranes in eastern mongolia a ten year update breeding populations of white naped cranes on decline in eastern mongolian stronghold using structure from motion mapping to record and analyze details of the colossal hats pukao of monumental statues on rapa nui easter island easter island had a cooperative community analysis of giant hats reveals forced resurgence and targeting of intracellular uropathogenic escherichia coli reservoirs ending recurrent urinary tract infections study with mice gives hope low and increasing trajectories of perpetration of physical dating violence year associations with suicidal ideation weapons and substance use intimate partner violence among youth linked to suicide weapons and drug use gwas of epigenetic aging rates in blood reveals a critical role for tert genome wide association study of epigenetic aging rates in blood reveals a critical role for tert development of the functional social network index for adolescent and young adult cancer survivors many adolescent and young adult cancer survivors have more social connections than peers subcallosal cingulate deep brain stimulation for treatment refractory anorexia nervosa a phase pilot trial deep brain stimulation shows promise for patients with chronic treatment resistant anorexia nervosa perinatal dna methylation at cdkn a is associated with offspring bone mass findings from the southampton women s survey early epigenetic switches associated with childhood bone health toward a social practice theory of relational competing new study debunks the theory of war like business competition in financial markets full characterization of polarization states of light via direct measurement getting around the uncertainty principle physicists make first direct measurements of polarization states of light inborn errors of long chain fatty acid oxidation link neural stem cell self renewal to autism research hints at a nutritional strategy for reducing autism risk hard magnet l copt nanoparticles advance fuel cell catalysis new durable catalyst for key fuel cell reaction may prove useful in eco friendly vehicles anthelminthic treatment during pregnancy is associated with increased risk of infantile eczema randomised controlled trial results exposure to worm infection in the womb may protect against eczema study suggests origin and lateral migration of linear dunes in the qaidam basin of nw china revealed by dune sediments internal structures and optically stimulated luminescence ages with implications for linear dunes on titan erosional origin of linear dunes on earth and saturn s moon titan salivary transcriptomic biomarkers for detection of resectable pancreatic cancer researchers find biomarkers in saliva for detection of early stage pancreatic cancer zinc sulfate and sugar alcohol zinc sprays at critical stages to improve apple fruit quality zinc sulfate sugar alcohol zinc sprays improve apple quality public interest in climate change over the past decade and the effects of the climategate media event public interest in climate change unshaken by scandal but unstirred by science f fac pet selectively images liver infiltrating cd and cd t cells in a mouse model of autoimmune hepatitis new study evaluates efficacy of pet imaging to manage chronic liver diseases symmetric achromatic variability in active galaxies a powerful new gravitational lensing probe ? cosmic magnifying lens reveals inner jets of black holes public primary and secondary skin cancer prevention perceptions and knowledge an international cross sectional survey study on sun protection behavior skin cancer awareness chronically inadequate sleep results in abnormal bone formation and abnormal bone marrow in rats lack of sleep affects bone health and bone marrow activity maternal viral infection during pregnancy elicits anti social behavior in neonatal piglet offspring independent of postnatal microglial cell activation infection in pregnant pigs leads to antisocial piglets clinical ascertainment of health outcomes among adults treated for childhood canceroutcomes among adult survivors of childhood cancer very high prevalence of chronic health conditions among adult survivors of childhood cancer hierarchical dominance structure in reintroduced california condors correlates consequences and dynamics novel study using new technologies outlines importance of california condor social groups temperature and acidification variability reduce physiological performance in the intertidal zone porcelain crab petrolisthes cinctipes climate change puts coastal crabs in survival mode study finds two dimensional mos enabled flexible rectenna for wi fi band wireless energy harvesting converting wi fi signals to electricity with new d materials preserving immunogenicity of lethally irradiated viral and bacterial vaccine epitopes using a radio protective mn peptide complex from deinococcus world s toughest bacterium holds promise for rapid vaccine development against deadly diseases the new runner s high ? examining relationships between cannabis use and exercise behavior in states with legalized cannabis the new runner s high ? some often mix weed workouts limited health knowledge as a reason for non use of four common complementary health practices knowledge about alternative medicine connected to education income self assembly of d nanostructures in electrospun polycaprolactone polyaniline fibers and their application as scaffolds for tissue engineering engineers craft the basic building block for electrospun nanofibers infant protection against influenza through maternal immunization a call for more immunogenic vaccines maternal vaccination against influenza associated with protection for infants absence of neurocognitive effect of hepatitis c infection in hiv coinfected people hepatitis c ruled out as cause of mental impairment in hiv patients functional modularity of the arginine catabolic mobile element contributes to the success of usa methicillin resistant staphylococcus aureus gene finding may lead to treatments effective against all mrsa strains gain of function mutation intrpv identified in patients with osteonecrosis of the femoral head researchers discover new genetic mutation linked to osteonecrosis of the hip the use of aquatic mammals for bait in global fisheries dolphins deliberately killed for use as bait in global fisheries pet imaging of tau deposition in the aging human brain pet scans reveal key details of alzheimer s protein growth in aging brains are fluoride levels in drinking water associated with hypothyroidism prevalence in england ? a large observational study of gp practice data and fluoride levels in drinking water water fluoridation in england linked to higher rates of underactive thyroid intratumor heterogeneity of the estrogen receptor and the long term risk of fatal breast cancer factor that doubles the risk of death from breast cancer identified a de novo nonsense mutation in magel in a patient initially diagnosed as opitz c similarities between schaaf yang and opitz c syndromes gene that causes rare disorder opitz c syndrome identified reduced anticoagulation after mechanical aortic valve replacement interim results from the prospective randomized on x valve anticoagulation clinical trial randomized food and drug administration investigational device exemption trial low dose anticoagulation therapy can be used safely with new design mechanical heart valve validation of the ottawa subarachnoid hemorrhage rule in patients with acute headache new tool identifies headache patients at risk of aneurysms in emergency department host group formation decreases exposure to vector borne disease a field experiment in a hotspot of west nile virus transmission birds roosting in large groups less likely to contract west nile virus atm mediated stabilization of zeb promotes dna damage response and radioresistance through chk protein zeb promotes breast tumor resistance to radiation therapy acute stress induces hyperacusis in women with high levels of emotional exhaustion stress makes exhausted women over sensitive to sounds safety and efficacy of focused ultrasound thalamotomy for patients with medication refractory tremor dominant parkinson disease focused ultrasound shows promise for treating parkinson s tremor rare bone diseases and their dental oral and craniofacial manifestations rare bone diseases and their dental oral craniofacial manifestations the novel mouse mutation oblivion inactivates the pmca pump and causes progressive hearing loss new mouse mutant contains clue to progressive hearing loss effects of ruminant trans fatty acids on cardiovascular disease and cancer a comprehensive review of epidemiological clinical and mechanistic studies expert calls for change in trans fat labelling early onset and classical forms of type diabetes show impaired expression of genes involved in muscle branched chain amino acids metabolism how body cells change during type diabetes onset screening for hyperbilirubinemia in japanese very low birthweight infants using transcutaneous bilirubinometry preventing cerebral palsy in preterm infants through dermal monitoring social determinants of risk and outcomes for cardiovascular disease addressing social factors critical for continued fight against heart disease and stroke in america the sequences of mutants in the model rice variety kitaake facilitate rapid functional genomic studies whole genome sequenced rice mutant resource for the study of biofuel feedstocks the drosophila zinc finger transcription factor ouija board controls ecdysteroid biosynthesis through specific regulation of spookier expression of a ouija board protein that can summon monster genes atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants eczema may play a key role in the development of food allergy in infants study suggests zoledronic acid reduces bone loss and tumor growth in an orthotopic xenograft model of osteolytic oral squamous cell carcinoma osteoporosis drug reduces bone loss tumor size in oral cancer noninvasive neutron scattering measurements reveal slower cholesterol transport in model lipid membranes precise measurements of cholesterol transport rates give new hope for alzheimer s treatment impact of peer support on acute care visits and hospitalizations for individuals with diabetes and depressive symptoms a cluster randomized controlled trial peer support can help curb acute care for persons with depression and diabetes emerging vs time tested methods of facial grading among patients with facial paralysis facial grading systems for patients with facial paralysis marine biominerals perspectives and challenges for polymetallic nodules and crusts bacteria and algae act as biocatalysts for deep sea raw material deposition integrated management of childhood illness imci strategy for children under five integrated management of childhood illness strategy for children under five systematic review transient hypoxemia chronically disrupts maturation of preterm fetal ovine subplate neuron arborization and activity lack of oxygen not blood flow delays brain maturation in preterm infants increase in the mediators of asthma in obesity and obesity with type diabetes reduction with weight loss obesity and asthma study finds a link in the genes clinical and radiological cervical spine evaluation in retired professional rugby players former professional rugby players have greater cervical spine degeneration lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging clearing clumps of protein in aging neural stem cells boosts their activity ckd as a model for improving chronic disease care through electronic health records new strategies for combatting chronic kidney disease other long term conditions indoor tanning and skin cancer risk among diverse us youth indoor tanning study reveals surprising new at risk group for skin cancer impact of the neglected tropical diseases on human development in the organisation of islamic cooperation nations ntds disproportionately found in areas of poverty in islamic nations unique lipids from a common human bacterium represent a new class of tlr ligands capable of enhancing autoimmunity factors from common human bacteria may trigger multiple sclerosis long range pcr allows sequencing of mitochondrial genomes from environmental dna better method for identifying aquatic species using environmental dna herbivores rescue diversity in warming tundra by modulating trait dependent species losses and gains reindeer grazing protects tundra plant diversity in a warming climate direct brain recordings reveal prefrontal cortex dynamics of memory development new memory study first to use intracranial recordings two new species of the genus cophixalus from the raja ampat islands west of new guinea amphibia anura microhylidae night calls reveal two new rainforest arboreal frog species from western new guinea neurogenesis dependent and independent effects of fluoxetine in an animal model of anxiety depression new mouse model of depression anxiety enhances understanding of antidepressant drugs using modelling to disentangle the relative contributions of zoonotic and anthroponotic transmission the case of lassa fever lassa fever controls need to consider human human transmission and role of super spreaders two novel loci cobl and slc a for alzheimer s disease in african americans study identifies two new genes responsible for alzheimer s disease among african americans reduced glomerular filtration rate and its association with clinical outcome in older patients at risk of vascular events secondary analysis impaired kidney function raises risk of heart problems in the elderly unstable housing and caregiver and child health in renter families housing instability negatively affects the health of children and caregivers will zika virus and microcephaly epidemics emerge after ebola in west africa ? the need for prospective studies now west africa ebola and the threat of zika three dimensional scaffolds of acellular human and porcine lungs for high throughput studies of lung disease and regeneration research on d scaffolds sets new bar in lung regeneration micro ct imaging of live insects using carbon dioxide gas induced hypoxia as anesthetic with minimal impact on certain subsequent life history traits new scanning process allows unprecedented look inside live insects antibiotic prescribing for acute non bacterial upper respiratory infections in the elderly half of all seniors who went to doctor for common cold prescribed unnecessary antibiotics regulation of cell polarity determinants by the retinoblastoma tumor suppressor protein brad pitt s and fruit flies cowlicks controlled by cancer protein higher order cognitive training effects on processing speed related neural activity a randomized trial cognitive training helps regain a younger working brain disclosure of complementary medicine use to medical providers a systematic review and meta analysis complementary medicine use remains hidden from conventional medicine providers human melanoma metastasis in nsg mice correlates with clinical outcome in patients spread of human melanoma cells in mice correlates with clinical outcomes in patients cross border policy effects on alcohol outcomes drinking without thinking on the u.s. mexico border ? bar attendance supports heavy drinking by young adults in the us mexico border region systemic aav mediated gene therapy drives whole body correction of myotubular myopathy in dogs new step toward the treatment of myotubular myopathy gene therapy restores strength and prolongs lives in affected dogs accumulation of coal combustion residues and their immunological effects in the yellow bellied slider trachemys scripta scripta colorful reptile serves as a health barometer for the impacts of coal waste alpha antitrypsin monotherapy reduces graft versus host disease after experimental allogeneic bone marrow transplantation natural enzyme provides potential new approach for treating graft vs. host disease joint histology in alligator mississippiensis challenges the identification of synovial joints in fossil archosaurs and inferences of cranial kinesis new research disproves common assumption on cranial joints of alligators birds dinosaurs targeted bisulfite sequencing reveals changes in dna methylation associated with nuclear reprogramming new method developed by bioengineers gives regenerative medicine a boost the association of mood disorders with breast cancer survival an investigation of linked cancer registration and hospital admission data for south east england lower survival rates in women with breast cancer diagnosed with depression the effect of a mobile health decision support system on diagnosis and management of obesity tobacco use and depression in adults and children mobile app with evidence based decision support diagnoses more obesity smoking and depression post exposure prophylaxis against ebola virus disease with experimental antiviral agents a case series of health care workers experimental post exposure antiviral treatment may protect humans from ebola virus sfrp is an anti inflammatory adipokine that modulates metabolic dysfunction in obesity protein identified that modulates metabolic dysfunction in obesity reversible adsorption of nitrogen dioxide within a robust porous metal organic framework mof material offers selective reversible and repeatable capture of toxic atmospheric gas synergistic effect of eribulin and cdk inhibition for the treatment of triple negative breast cancer drug combo gangs up to take on triple negative breast cancer formin links neuropsychiatric phenotypes at young age to an increased risk for dementia molecular link between post traumatic stress disorder and alzheimer s disease exome sequencing reveals vcp mutations as a cause of familial als mutation linked to protein degradation underlies inherited als a novel kindred with inherited stat deficiency and severe viral illness new insights in genetic defect allow prevention of fatal illnesses in children multiscale prediction of patient specific platelet function under flow large scale simulation of human blood is boon to personalized medicine association of maternal and paternal depression in the postnatal period with offspring depression at age years post natal depression in dads linked to depression in their teenage daughters radiofrequency ablation in barrett s esophagus with dysplasia technique eradicates problems in most patients with barrett s esophagus calcium and vitamin d disparities are related to gender age race household income level and weight classification but not vegetarian status in the united states analysis of the nhanes data set vitamin d calcium disparities found among american subpopulations poly is more effective than monounsaturated fat for dietary management in the metabolic syndrome the muffin study the muffin study mono vs. polyunsaturated fats in patients with metabolic syndrome robotic level iii inferior vena cava tumor thrombectomy the initial series first reports of robotic surgery for advanced vena cava tumor thrombus due to kidney cancer caffeine in floral nectar enhances a pollinator s memory of reward bees get a buzz from flower nectar containing caffeine il is essential for host defense against cutaneous staphylococcus aureus infection in mice bacteriology staph infections in the skin controlled by the immune molecule il the use of primate actors in feature films use of primate actors misleading millions of viewers a cluster randomised control trial to evaluate the effectiveness and cost effectiveness of the italian medicines use review i mur for asthma patients asthma intervention study points to care and cost benefits deep brain stimulation of frontal lobe networks to treat alzheimer s disease brain pacemaker study shows promise in slowing decline of alzheimer s mesenchymal stem cells for bronchopulmonary dysplasia phase dose escalation clinical trial stem cells to treat lung disease in preterm infants visual advantage in deaf adults linked to retinal changes retina holds the key to better vision in deaf people crowdsourcing harnessing the masses to advance health and medicine a systematic review promise of human computing power via crowdsourcing to speed medical research ancient mitochondrial genomes clarify the evolutionary history of new zealand s enigmatic acanthisittid wrens new zealand wren dna analysis reshapes geological theory dominance of the cd t helper cell response during acute resolving hepatitis a virus infection helper t cells not killer t cells might be responsible for clearing hepatitis a infection sex differences in the gut microbiome drive hormone dependent regulation of autoimmunity good bacteria in the intestine prevent diabetes study suggests duration of symptoms resulting from lumbar disc herniation effect on treatment outcomes analysis of the spine patient outcomes research trial sport surgical treatment within six months of lumbar disc herniation symptoms associated with improved outcomes safety pharmacokinetics and preliminary assessment of efficacy of mecasermin recombinant human igf for the treatment of rett syndrome rett syndrome drug shows promise in clinical trial association of skin cancer and indoor tanning in sexual minority men and women gay bisexual men report higher rates of indoor tanning skin cancer than heterosexual men gene therapy by allele selection in a mouse model of beta thalassemia embryonic stem cells help deliver good genes in a model of inherited blood disorder a metal free organic inorganic aqueous flow battery organic mega flow battery promises breakthrough for renewable energy experimental pain processing in individuals with cognitive impairment altered pain processing in patients with cognitive impairment preterm birth and childhood wheezing disorders a systematic review and meta analysis preterm birth is associated with increased risk of asthma and wheezing disorders nano tags for neonates and ocean mediated swimming behaviours linked to rapid dispersal of hatchling sea turtles sea turtles first days of life sprint and ride towards safety seasonal influenza vaccination is the strongest correlate of cross reactive antibody responses in migratory bird handlers seasonal flu vaccines boost immunity to many types of flu viruses research suggests association of amyloid positron emission tomography with subsequent change in clinical management among medicare beneficiaries with mild cognitive impairment or dementia alzheimer s diagnosis management improved by brain scans conscientious objection in medical students a questionnaire survey conscientious objection to any procedure is doctor s right say medical students histone demethylases kdm a and kdm c regulate differentiation of embryonic stem cells to endothelial cells researchers uncover epigenetic switches that turn stem cells into blood vessel cells marshmallow like silicone gels as flexible thermal insulators and liquid nitrogen retention materials and their application in containers for cryopreserved embryos marshmallow like silicone gels used as insulation in containers for cryopreserved embryos lifetime risk for sudden cardiac death in the community men may face high lifetime risk of sudden cardiac death lack of efficacy of an intradural somatic to autonomic nerve anastomosis xiao procedure for bladder control in children with myelomeningocele and lipomyelomeningocele results of a prospective randomized double blind study double blinded randomized controlled trial of the xiao procedure in children quantum artificial life in an ibm quantum computer model of quantum artificial life on quantum computer direct and indirect parental exposure to endocrine disruptors and elevated temperature influences gene expression across generations in a euryhaline model fish warmer water chemical exposure influence gene expression across generations in a coastal fish activation of germline specific genes is required for limb regeneration in the mexican axolotl understanding how salamanders grow new limbs provides insights into potential of human regenerative medicine human embryonic stem cell derived cardiomyocytes restore function in infarcted hearts of non human primates stem cells restore function in primate heart failure study negative pressure induced helimagnetism in ferromagnetic cubic perovskites sr xbaxcoo crystal clear understanding magnetism changes caused by crystal lattice expansion intravenously administered nanoparticles increase survival following blast trauma clot building nanoparticles raise survival rate following blast trauma regular exercise quality of life and mobility in parkinson s disease a longitudinal analysis of national parkinson foundation quality improvement initiative data exercising. hours per week associated with slower declines in parkinson s disease patients a year record of caribbean reef urchin communities reveals causes and consequences of long term decline in diadema antillarum rise of aggressive reef predator may impede sea urchin recovery study finds knockout of the pkn family of rho effector kinases reveals a non redundant role for pkn in developmental mesoderm expansion new role of protein kinases in embryo development and cancer global food security in the role of agricultural productivity and climate change drop in global malnutrition depends on agricultural productivity climate change effect of b vitamin supplementation on plasma homocysteine levels in celiac disease are vitamin supplements effective in celiac disease patients ? overcoming therapeutic resistance in her positive breast cancers with cdk inhibitors new agent overcomes drug resistance in her positive breast cancer preclinical study shows non invasive brain stimulation for fine motor improvement after stroke a meta analysis noninvasive brain stimulation leads to fine motor improvement after stroke genetic assessment of age associated alzheimer disease risk development and validation of a polygenic hazard score genetic assessment developed to determine risk for age associated alzheimer s disease zygotes segregate entire parental genomes in distinct blastomere lineages causing cleavage stage chimerism and mixoploidy single cell analysis of embryos reveals mis segregation of parental genomes ab initio spectroscopy and ionic conductivity of water under earth mantle conditions better model of water under extreme conditions could aid understanding of earth s mantle the oldest record of alvarezsauridae dinosauria theropoda in the northern hemisphere alvarezsaurid dinosaur from the late cretaceous found in uzbekistan alternative nhej pathway components are therapeutic targets in high risk neuroblastoma alternative dna repair mechanism could provide better treatment for neuroblastoma in kids association of adolescent obesity with risk of severe obesity in adulthood obesity in adolescence significantly associated with increased risk of severe obesity in adulthood single shot compressed optical streaking ultra high speed photography new photography approach gives traditional cameras ultra high imaging speeds genetically corrected ipscs as cell therapy for recessive dystrophic epidermolysis bullosa tremendous progress in development of skin stem cell treatments for butterfly children the association between major depressive disorder in childhood and risk factors for cardiovascular disease in adolescence childhood depression may increase risk of heart disease by teen years magnon detection using a ferroic collinear multilayer spin valve construction set of magnon logic extended magnon spin currents can be controlled via spin valve structure two pressure induced superconducting transitions in snbi se explored by data driven materials search new approach to developing novel functional materials including thermoelectric and superconducting materials discovery of new superconducting materials using materials informatics detection of nanoflare heated plasma in the solar corona by the foxsi sounding rocket solar research nasa sounding rocket instrument spots signatures of long sought small solar flares infantile fibrosarcoma withntrk etv fusion successfully treated with the tropomyosin related kinase inhibitor loxo rare pediatric cancer successfully treated with new targeted therapy prospective randomized multicenter food and drug administration investigational device exemption study of the prodisc l total disc replacement compared with circumferential arthrodesis for the treatment of two level lumbar degenerative disc disease res artificial disc a viable alternative to fusion for two level disc disease study finds identification of a narrow post ovulatory window of vulnerability to distressing involuntary memories in healthy women hormone levels may provide key to understanding psychological disorders in women college students multitasking behavior in online versus face to face courses multitasking increases in online courses compared to face to face breast cancer after use of estrogen plus progestin and estrogen alone women s health initiative on menopausal hormone therapy and breast cancer brood care in a million year old scale insect the million year old piggyback amber reveals earliest example of maternal care in insects diminishing benefit of smoking cessation medications during the first year a meta analysis of randomized controlled trials benefits of smoking cessation medications diminish over time the incidence and impact of dog attacks on guide dogs in the uk an update increase in the number of dog attacks on guide dogs in the uk reduced adenosine to inosine mir p editing promotes melanoma growth and metastasis lack of rna editing leads to melanoma growth metastasis a luminous blue kilonova and an off axis jet from a compact binary merger at z. all in the family kin of gravitational wave source discovered tracking viral genomes in host cells at single molecule resolution tracking viral dna in the cell new method to generate virus particles containing labeled viral dna genomes possible freshwater dinoflagellate cysts and colonial algae from the upper jurassic strata of the surat basin australia red tide fossils point to jurassic sea flood early african fossils elucidate the origin of embrithopod mammals ancient moroccan dental remains elucidate history of long lost african fauna an unusual splice defect in the mitofusin gene mfn is associated with degenerative axonopathy in tyrolean grey cattle cause of demetz syndrome in tyrolean grey cattle discovered lead exposure and food processing in white tailed eagles and other scavengers an experimental approach to simulate lead uptake at shot mammalian carcasses white tailed eagles avoid large bullet fragments during consumption of carcasses initial study on thatched roofing assembly ignition vulnerabilities to firebrand showers a fire breathing dragon helps fight ember attacks on thatched roof buildings embryonic transcription factor expression in mice predicts medial amygdala neuronal identity and sex specific responses to innate behavioral cues transcription factor expression tied to medial amygdala neuronal id sex specific response abnormal capillary vasodynamics contribute to ictal neurodegeneration in epilepsy lack of oxygen not excessive stimulation cause for half of seizure related brain damage in epilepsy ecosystem carbon response of an arctic peatland to simulated permafrost thaw new research from arctic thawing permafrost peatlands may add to atmospheric co burden palaeogenomes of eurasian straight tusked elephants challenge the current view of elephant evolution genetic study shakes up the elephant family tree turbidite event history methods and implications for holocene paleoseismicity of the cascadia subduction zone northwest earthquake risk in u.s. looms large chance of major earthquake within years impact of gender on arterial revascularization strategies for coronary artery bypass grafting delayed diagnosis not gender affects women s treatment for heart disease guide seq enables genome wide profiling of off target cleavage by crispr cas nucleases new method identifies genome wide off target cleavage sites of crispr cas nucleases schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice therapeutic effect of worm derived proteins on experimental colitis oh the earliest evidence for right handedness in the fossil record earliest evidence in fossil record for right handedness why wet feels wet ? a neurophysiological model of human cutaneous wetness sensitivity why wet feels wet understanding the illusion of wetness from the mouths of monkeys detection of mycobacterium tuberculosis complex dna from buccal swabs of synanthropic macaques from the mouths of monkeys swab technique spots tuberculosis in non human primates accelerated bone regeneration by two photon photoactivated carbon nitride nanosheets new stem cell technique shows promise for bone repair multiethnic gwas reveals polygenic architecture of earlobe attachment do your ears hang low ? the complex genetics behind earlobe attachment rhinoceros beetle horn development reveals deep parallels with dung beetles common genetic toolkit shapes horns in scarab beetles endothelial and astrocytic support by human bone marrow stem cell grafts into symptomatic als mice towards blood spinal cord barrier repair stem cell transplants may advance als treatment by repair of blood spinal cord barrier superficial simplicity of the el mayor cucapah earthquake of baja california in mexico el mayor cucapah earthquake was simple on surface complicated at depth new data show spatial analysis of exposure to traffic related air pollution at birth and childhood atopic asthma in toronto ontario children with asthma likely born in area with high air pollution anthropometric metabolic and molecular determinants of human epidermal growth factor receptor expression in luminal b breast cancer breast cancer anthropometric and metabolic dowels integrate metabolic details and contribute to an increasingly complex puzzle directed evolution of cytochrome c for carbon silicon bond formation bringing silicon to life bringing silicon to life scientists persuade nature to make silicon carbon bonds accelerated cloning of a potato late blight resistance gene using renseq and smrt sequencing forming a second line of plant defense capturing disease resistant dna automated mound detection using lidar and object based image analysis in beaufort county south carolina archaeologists identify ancient north american mounds using new image analysis technique structure of human tfiid and mechanism of tbp loading onto promoter dna freeze frame microscopy captures molecule s lock and load on dna a new species of coespeletia asteraceae millerieae from venezuela crown of venezuelan paramos a new species from the daisy family coespeletia palustris dna methylation age of human tissues and cell types scientist uncovers internal clock able to measure age of most human tissues women s breast tissue ages faster than rest of body inflammation induced iga cells dismantle anti liver cancer immunity how chronic inflammation tips the balance of immune cells to promote liver cancer estrogen receptor polymorphism in a species with alternative behavioral phenotypes wild sparrow study traces social behaviors in the field to specific gene twelve single nucleotide polymorphism genetic risk score identifies individuals at increased risk for future atrial fibrillation and stroke genetic test reveals risk of atrial fibrillation stroke infant walker related injuries in the united states injuries associated with infant walkers still sending children to the emergency department variable assessment of wing colouration in aerial contests of the red winged damselfly mnesarete pudica zygoptera calopterygidae damselfly war games flying insects take note of opponents strengths abilities before entering into a fight the burden of opioid related mortality in the united states one in every deaths in young adults is opioid related in the united states ataluren for the treatment of nonsense mutation cystic fibrosis a randomised double blind placebo controlled phase trial ataluren phase trial results in nonsense mutation cystic fibrosis confocal raman microspectroscopy as an analytical tool to assess the mitochondrial status in human spermatozoa non invasive technique could distinguish fertile and infertile human sperm cells long term biological and behavioural impact of an adolescent sexual health intervention in tanzania follow up survey of the community based mema kwa vijana trial limited long term effects of school based sexual health education childhood self control and unemployment throughout the life span evidence from two british cohort studies childhood self control linked to enhanced job prospects throughout life handball load and shoulder injury rate a week cohort study of elite youth handball players youth handball players get injured by sudden increases in training volume transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming genome architecture s surprising role in cell fate decisions birc ciap is a negative regulator of hiv transcription and can be targeted by smac mimetics to promote reversal of viral latency researchers reawaken sleeping hiv in patient cells to eliminate the virus a synopsis of the tribe lachnophorini with a new genus of neotropical distribution and a revision of the neotropical genus asklepia liebke insecta coleoptera carabidae a synopsis of the carabid beetle tribe lachnophorini reveals remarkable new species driving behaviors in adults with autism spectrum disorders do people with autism struggle with driving ? hydraulic fracturing volume is associated with induced earthquake productivity in the duvernay play fox creek earthquakes linked to completion volume and location of hydraulic fracturing reasoning training in veteran and civilian traumatic brain injury with persistent mild impairment brain training induces lasting brain mental health gains for veterans civilians with brain injury marathon penguins reasons and consequences of long range dispersal in fiordland penguins tawaki during the pre moult period new zealand penguins make mammoth migrations traveling thousands of kilometers to feed prenatal exposure to hyperemesis gravidarum linked to increased risk of psychological and behavioral disorders in adulthood extreme morning sickness could lead to lifelong emotional behavioral disorders in kids tau does not stabilize axonal microtubules but rather enables them to have long labile domains tau does not stabilize microtubules in brain study finds a longitudinal study of phenotypic changes in early domestication of house mice mice change their appearance as a result of frequent exposure to humans genetic association of cyclic amp signaling genes with bipolar disorder scientists pinpoint gene variations linked to higher risk of bipolar disorder multiple sclerosis changes in thalamic resting state functional connectivity induced by a home based cognitive rehabilitation program video games improve brain connections in multiple sclerosis patients a high resolution chronology of rapid forest transitions following polynesian arrival in new zealand small new zealand population initiated rapid forest transition c. years ago drier forests lost within decades instead of centuries as previously thought recessive gm synthase deficiency natural history biochemistry and therapeutic frontier largest description of st gal gm synthase deficiency published relationship between vaginal microbial dysbiosis inflammation and pregnancy outcomes in cervical cerclage pregnancy procedure may be associated with increased risk of premature birth and neonatal loss potential use of the human amniotic membrane as a scaffold in human articular cartilage repair amniotic membrane used to repair human articular cartilage an epigenetic pathway regulates sensitivity of breast cancer cells to her inhibition via foxo c myc axis turncoat protein regulates sensitivity of breast cancer cells to drug policy implications of marked reversals of population life expectancy caused by substance use link between public policy life expectancy reinforced by new international research whole genome sequencing of the world s oldest people whole genome sequences of the world s oldest living people no genes significantly associated with extreme longevity effects of vitamin b supplementation on neurologic and cognitive function in older people a randomized controlled trial benefits of vitamin b supplements for older people questioned effect of a collaborative care intervention vs usual care on health status of patients with chronic heart failure improving quality of life for people with chronic heart failure repetitive transcranial magnetic stimulation once a week induces sustainable long term relief of central poststroke pain weekly non invasive brain stimulation provides long term relief of post stroke pain convoluted nasal passages function as efficient heat exchangers in ankylosaurs dinosauria ornithischia thyreophora huge armored dinosaurs battled overheating with nasal air conditioning associations of cognitive function scores with carbon dioxide ventilation and volatile organic compound exposures in office workers a controlled exposure study of green and conventional office environments green office environments linked with higher cognitive function scores replacement of the european wheat yellow rust population by new races from the centre of diversity in the near himalayan region invasions out of center of diversity increase risk of disease epidemics in wheat synthetic phosphorus metabolic pathway for biosafety and contamination management of cyanobacterial cultivation new biocontainment strategy controls spread of escaped gmos brainstem functional connectivity disturbances in epilepsy may recover after successful surgery brain network activity can improve in epilepsy patients after surgery cd null pro atherogenic cd t cells explain the link between cmv infection and an increased risk of cardiovascular death link between common harmless virus and cardiovascular damage increased fluxes of shelf derived materials to the central arctic ocean scientists find surprising evidence of rapid changes in the arctic total and cancer mortality after supplementation with vitamins and minerals follow up of the linxian general population nutrition intervention trial reductions in cancer and overall mortality persist years after vitamin and mineral supplementation microglia play an active role in obesity associated cognitive decline immune cells destroy healthy brain connections diminish cognitive function in obese mice an endometrial gene expression signature accurately predicts recurrent implantation failure after ivf fertility experts identify genetic pattern in womb linked to ivf failure maternal high fat diet in mice leads to innate airway hyperresponsiveness in the adult offspring high fat diet during pregnancy compromises offspring s lung health meckel s diverticulum masked by a long period of intermittent recurrent subocclusive episodes meckel s diverticulum masked by intermittent recurrent subocclusive episodes compassion fatigue a review of the research to date and relevance to cancer care providers compassion fatigue impact on healthcare providers of caring for the terminally ill identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach new biomarkers for predicting the spread of colon cancer proportion of cancer cases attributable to excess body weight by us state proportion of cancers associated with excess body weight varies considerably by state infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis study identifies reasons for higher rate of severe sepsis among black patients efficacy of the new neuraminidase inhibitor cs against h n influenza viruses novel compound found effective against avian influenza virus prelude to extinction a seismically induced onshore surge deposit at the kpg boundary north dakota million year old deathbed linked to dinosaur killing meteor new regimens to prevent tuberculosis in adults with hiv infection combination therapy as good as old regimen to prevent full blown tb in people with without hiv antiviral treatment for bell s palsy idiopathic facial paralysis bell s palsy study calls for rethink of cause and treatment neural control of dynamic dimensional skin papillae for cuttlefish camouflage how the cuttlefish spikes out its skin neurological study reveals surprising control chronic pain and analgesic use in ckd implications for patient safety most patients with chronic kidney disease may experience long term pain long term fish assemblages of the ohio river altered trophic and life history strategies with hydrologic alterations and land use modifications freshwater fish species richness has increased in ohio river basin since s detection of the aromatic molecule benzonitrile c c h cn in the interstellar medium faint galactic glow intriguing organic molecule benzonitrile in interstellar space induction of tumoricidal function in cd t cells is associated with concomitant memory and terminally differentiated phenotype mouse model exposes a new type of t cell to target melanoma precision targeted therapy with blu for ret driven cancers first in human clinical trial of new targeted therapy drug reports promising responses for multiple cancers myeloid derived interleukin drives oncogenic kras nf addiction in malignant pleural effusion water in the chest new findings on pleural effusion dose dependence of fetal malformations associated with valproate epilepsy drug dosage linked to specific birth defects quantitative characterization of genetic parts and circuits for plant synthetic biology programmable plants synthetic biologists pave way for genetic circuits anti inflammatory properties of a colored avocado seed extract avocado seed extract shows promise as anti inflammatory compound potential decline in carbon carrying capacity under projected climate wildfire interactions in the sierra nevada changing climate could have devastating impact on forest carbon storage blowin in the wind short term weather and belief in anthropogenic climate change climate change beliefs of independent voters shift with the weather sex differences in parent reported executive functioning and adaptive behavior in children and young adults with autism spectrum disorder females with autism show greater difficulty with day to day tasks than male counterparts an extracorporeal blood cleansing device for sepsis therapy blood cleansing biospleen device developed for sepsis therapy chitosan decorated doxorubicin encapsulated nanoparticle targets and eliminates tumor reinitiating cancer stem like cells chitosan coated chemotherapy packed nanoparticles may target cancer stem cells eligibility for statin therapy according to new cholesterol guidelines and prevalent use of medication to lower lipid levels in an older us cohort most older adults qualify for statin therapy under new cholesterol guidelines study show updated us public health service guidelines for the management of occupational exposures to human immunodeficiency virus and recommendations for postexposure prophylaxis new federal guidelines for managing occupational exposures to hiv hoxb intersection defines a role for lmx b in excitatory dorsal horn neuron development spinofugal connectivity and nociception discovery could impact study of chronic pain conditions layer specific observation of slow thermal equilibration in ultrathin metallic nanostructures by femtosecond x ray diffraction future information technologies nanoscale heat transport under the microscope drivers of inter individual variation in dengue viral load dynamics dengue strains differ in rates of viral replication examining the efficacy of the modified story memory technique msmt in persons with tbi using functional magnetic resonance imaging fmri brain activity changes after cognitive rehabilitation tbi study shows a year study of high cost users of health care five percent of ontario residents account for majority of health care costs a randomized controlled trial of hanen s more than words in toddlers with early autism symptoms interest in toys predicts effectiveness of autism treatment in toddlers pre hispanic fishing practices in interfluvial amazonia zooarchaeological evidence from managed landscapes on the llanos de mojos savanna ancient fish ponds in the bolivian savanna supported human settlement the complete connectome of a learning and memory centre in an insect brain first circuit map of brain s learning and memory center the cardiac tbx interactome reveals a chromatin remodeling network essential for cardiac septation scientists elucidate genetic underpinnings of congenital heart disease exposure to child directed tv advertising and preschoolers intake of advertised cereals exposure to sugary breakfast cereal advertising directly influences children s diets high risk breast lesions a machine learning model to predict pathologic upgrade and reduce unnecessary surgical excision machine learning identifies breast lesions likely to become cancer maternal depression alters stress and immune biomarkers in mother and child maternal depression may alter stress and immune markers in children deterministic restriction on pluripotent state dissolution by cell cycle pathways molecular cell cycle clock discovered that controls stem cell potency association of uhrf with methylated h k directs the maintenance of dna methylation scientists find missing link between players in the epigenetic code the protein compromised hydrolysis of triacylglycerols cht acts as a repressor of cellular quiescence in chlamydomonas discovery of cellular snooze button advances cancer biofuel research medicaid dental coverage alone may not lower rates of dental emergency department visits dental coverage for patients with medicaid may not prevent tooth related er visits energy budget constraints on climate sensitivity in light of inconstant climate feedbacks models observations not so far apart on planet s response to greenhouse gas emissions acute aerobic exercise an intervention for the selective visual attention and reading comprehension of low income adolescents minutes of exercise improves attention reading comprehension in low income adolescents senolytics in idiopathic pulmonary fibrosis results from a first in human open label pilot study first in human trial of senolytic drugs encouraging the tumor necrosis factor family member light is a target for asthmatic airway remodeling new therapeutic target for asthma copd and other lung disorders identified a systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics our microbes are a rich source of drugs attributing changing rates of temperature record breaking to anthropogenic influences human caused warming increasing likelihood of record breaking hot years antibody secreting cell responses following vaccination with bivalent oral cholera vaccine among haitian adults cholera vaccine study in haiti suggests problems with current booster regimen decline in prescription opioids attributable to decreases in long term use a retrospective study in the veterans health administration long term opioid use has dropped among us military veterans selective light triggered release of dna from gold nanorods switches blood clotting on and off laser controlled molecular switch turns blood clotting on off on command estimated effects of different alcohol taxation and price policies on health inequalities a mathematical modelling study predicted impact of different alcohol taxation pricing policies on health inequalities isolation of cultivation resistant oomycetes first detected as amplicon sequences from roots of herbicide terminated winter rye basic microbiology research study unexpectedly uncovers practical findings for growers community epidemiology of risk and adolescent substance use practical questions for enhancing prevention protective communities may reduce risk of drinking in teens hepatitis b virus core protein allosteric modulators can distort and disrupt intact capsids virus cracking molecules advance fight against hepatitis b medicine public health and the populist radical right populist radical right a threat to core values of medicine and public health chronic effects of shift work on cognition findings from the visat longitudinal study long term shift work linked to impaired brain power effects of intravenous administration of allogenic bone marrow and adipose tissue derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke stem cells aid recovery from stroke study suggests the dental phenotype of hairless dogs with foxi haploinsufficiency foxi gene is involved in dental cusp formation evidence for electron landau damping in space plasma turbulence spacecraft measurements reveal mechanism of solar wind heating augmentation of m type kcnq potassium channels as a novel strategy to reduce stroke induced brain injury anti epilepsy drug preserves brain function after stroke research suggests an atp binding cassette subfamily g full transporter is essential for the retention of leaf water in both wild barley and rice newly discovered gene sheds light on the evolution of life on earth an intranasal virus like particle vaccine broadly protects mice from multiple subtypes of influenza a virus virus like particle vaccine protects mice from many flu strains systemic mesenchymal stromal cell transplantation prevents functional bone loss in a mouse model of age related osteoporosis stem cell therapy reverses age related osteoporosis in mice impact of hormone receptor status on patterns of recurrence and clinical outcomes among patients with human epidermal growth factor positive breast cancer in the national comprehensive cancer network a prospective cohort study breast cancer recurrence defined by hormone receptor status a robust fuel cell operated on nearly dry methane at c enabled by synergistic thermal catalysis and electrocatalysis finally a robust fuel cell that runs on methane at practical temperatures benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia a randomised double blind placebo controlled phase a study benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia high and dry post fire tree seedling establishment in subalpine forests decreases with post fire drought and large stand replacing burn patches drought alters recovery of rocky mountain forests after fire human stem cell derived astrocytes replicate human prions in aprnpgenotype dependent manner brain cell advance brings fresh hope for creutzfeldt jakob disease therapies rnai screen identifies essential regulators of human brain metastasis initiating cells new genes discovered regulating brain metastases in lung cancer patients backbone modification of a polypeptide drug alters duration of action in vivo chemical strategy hints at better drugs for osteoporosis diabetes green and blue water demand from large scale land acquisitions in africa foreign farms increase the risk of conflicts in africa accurate fully automated nmr spectral profiling for metabolomics machine learning breakthrough paves way for medical screening prevention and treatment characterizing the duration and severity of fishing gear entanglement on a north atlantic right whale eubalaena glacialis using stable isotopes steroid and thyroid hormones in baleen impact of fishing gear entanglement deduced from whale hormone levels early land use and centennial scale changes in lake water organic carbon prior to contemporary monitoring historical land use an important factor for carbon cycling in northern lakes high red and processed meat consumption is associated with non alcoholic fatty liver disease and insulin resistance high consumption of red and processed meat linked to non alcoholic fatty liver disease and insulin resistance cholesterol uptake capacity a new measure of hdl functionality for coronary risk assessment first of its kind test for hdl cholesterol function could transform the way healthcare providers predict your risk for heart disease galactic cosmic ray simulation at the nasa space radiation laboratory cloudy with a chance of radiation nasa studies simulated radiation first systematic assessment of dental growth and development in an archaic hominin genus homo from east asia an ancient relative of humans shows a surprisingly modern trait dust affects chewing efficiency and tooth wear in forest dwelling western chimpanzees pan troglodytes verus dust affects tooth wear and chewing efficiency in chimpanzees retinoic acid induces hyperactivity and blocking its receptor unmasks light responses and augments vision in retinal degeneration therapy could improve and prolong sight in those suffering vision loss antibody based delivery of il to the neovasculature cures mice with arthritis curing rheumatoid arthritis in mice antibody based delivery of il prolonged prophylactic protection from botulism with a single adenovirus treatment promoting serum expression of a vhh based antitoxin protein efficacy of new gene therapy approach for toxin exposures shown in mouse study coordinated parental provisioning is related to feeding rate and reproductive success in a songbird share the care long tailed tits show coordinated parenting is beneficial for chicks young women s perceptions of traditional and contemporary female beauty ideals in china views of ideal female appearance in china are changing regional and global sea surface temperatures during the last interglaciation sea surface temps during last interglacial period like modern temps noise overexposure alters long term somatosensory auditory processing in the dorsal cochlear nucleus possible basis for tinnitus related hyperactivity ? tinnitus new evidence touch sensing nerve cells may fuel ringing in the ears an immunogenomic stratification of colorectal cancer implications for development of targeted immunotherapy new potential for personalized treatments in bowel cancer natural selection against a circadian clock gene mutation in mice rotation speed may be bad news for red planet pioneers hot edges in an inverse opal structure enable efficient co electrochemical reduction and sensitive in situ raman characterization electrode s hot edges convert carbon dioxide gas into fuels and chemicals socioeconomic position is associated with carotid intima media thickness in mid childhood the longitudinal study of australian children disadvantaged kids may be at higher risk for heart disease later in life resolving the life cycle alters expected impacts of climate change global warming lethal to baby lizards nests become heat traps moderate alcohol intake is associated with lower dementia incidence results from the ginkgo evaluation of memory study gems regular moderate alcohol intake has cognitive benefits in older adults limits on stellar mass compact objects as dark matter from gravitational lensing of type ia supernovae black holes ruled out as universe s missing dark matter preexisting human antibodies neutralize recently emerged h n influenza strains seasonal flu vaccine induces antibodies that protect against h n avian flu proteomics reveals nnmt as a master metabolic regulator of cancer associated fibroblasts changes in the metabolism of normal cells promotes the metastasis of ovarian cancer cells extracts from two ubiquitous mediterranean plants ameliorate cellular and animal models of neurodegenerative proteinopathies chemicals in ubiquitous mediterranean plants may hold key to delaying neurodegenerative diseases study suggests overly aggressive new guidelines for lipid screening in children evidence of a broken process new lipid screening guidelines for children overly aggressive experts say termite mounds can increase the robustness of dryland ecosystems to climatic change tiny termites can hold back deserts by creating oases of plant life genetic evidence for causal relationships between maternal obesity related traits and birth weight link between genetically elevated maternal bmi higher offspring birth weight sensitivity and specificity of proposed dsm diagnostic criteria for autism spectrum disorder autism by the numbers researchers examine impact of new diagnostic criteria three dimensional topographies of water surface dimples formed by superhydrophobic water strider legs shadow method reveals locomotion secrets of water striders efficacy of recreational football on bone health body composition and physical functioning in men with prostate cancer undergoing androgen deprivation therapy week follow up of the fc prostate randomised controlled trial soccer strengthens bones of men with prostate cancer the relationship between vessel traffic and noise levels received by killer whales orcinus orca vessel speed biggest factor in noise affecting killer whales dependence of fertility on kisspeptin gpr signaling at the gnrh neuron final piece found in puzzle of brain circuitry controlling fertility environmental influence on the prevalence and pattern of airway dysfunction in elite athletes the impact of extreme exercise on breathing in gb olympic boxers and swimmers identification of fetoprotein specific t cell receptors for hepatocellular carcinoma immunotherapy new receptor genes turn t cells into powerful liver cancer foes effect of presymptomatic body mass index and consumption of fat and alcohol on amyotrophic lateral sclerosis effect of presymptomatic bmi dietary intake alcohol on als flagellin enhances saliva iga response and protection of anti caries dna vaccine dna vaccines show promise in preventing dental caries african ancestry is associated with higher intraocular pressure in latinos for latinos african ancestry adds to risk of glaucoma a protocol for bioinspired design a ground sampler based on sea urchin jaws sea urchin s teeth inspire new design for space exploration device the expanding role of primary care in cancer control primary care doctors are ill prepared to deal with growing demand for cancer care medicaid savings from the new york university caregiver intervention for families with dementia intervention for caregivers of dementia patients can lead to substantial medicaid savings survival comparison of patients with cystic fibrosis in canada and the united states differences in lifespan between canadians americans with cystic fibrosis study finds in drop capillary spooling of spider capture thread inspires hybrid fibers with mixed solid liquid mechanical properties scientists create novel liquid wire material inspired by spiders capture silk self organizing human cardiac microchambers mediated by geometric confinement human heart on a chip screens drugs for potential benefit harm plant roots use a patterning mechanism to position lateral root branches toward available water water found to provide blueprints for root architecture enhancing latent cognitive capacity in mild cognitive impairment with gist reasoning training a pilot study training helps those with mild cognitive impairment study shows arginine vasopressin is a blood based biomarker of social functioning in children with autism low levels of hormone linked to social deficit in autism study finds igf degradation by mouse mast cell protease promotes cell death and adverse cardiac remodeling days after a myocardial infarction long after heart attack chymase inhibitors could extend cell survival light drinking during pregnancy still no increased risk for socioemotional difficulties or cognitive deficits at years of age ? light drinking during pregnancy harmful to child s behavioral or intellectual development ? elevated plasma fibrinogen caused by inadequate linolenic acid intake can be reduced by replacing fat with canola type rapeseed oil canola type rapeseed oil reduces the level of fibrinogen a cause of thrombosis and inflammation study finds probiotics biofilm integrated electrospun nanofiber membranes a new starter culture for fermented milk production healthier dairy products with bacterial films and nanofiber membranes a decision analytic approach to predict state regulation of hydraulic fracturing hydraulic fracturing helping businesses predict national fracking policy comparison of human embryonic stem cell derived cardiomyocytes cardiovascular progenitors and bone marrow mononuclear cells for cardiac repair cardiac muscle cells as good as progenitors for heart repair assessing the preparedness of the u.s. health care system infrastructure for an alzheimer s treatment u.s. health care system unprepared to move future alzheimer s treatment into rapid clinical use variation in insurance status by patient demographics and tumor site among nonelderly adult patients with cancer health insurance coverage among cancer patients varies greatly by demographics and cancer type acute dietary nitrate intake improves muscle contractile function in patients with heart failureclinical perspective beet juice boosts muscle power in heart patients the effect of mindfulness group therapy on a broad range of psychiatric symptoms a randomised controlled trial in primary health care mindfulness just as effective as cbt for a broad range of psychiatric symptoms surveillance report of zika virus among canadian travellers returning from the americas zika virus in canadian travelers more severe than expected injuries associated with long working hours among employees in the us mining industry risk factors and adverse outcomes irregular schedules raise risk of injury for miners working long hours metarhizium brunneum blastospore pathogenesis in aedes aegypti larvae attack on several fronts accelerates mortality how fungi stage a deadly under water attack on aedes mosquito larvae delayed initial radioactive iodine therapy resulted in poor survival in patients with metastatic differentiated thyroid carcinoma a retrospective statistical analysis of cases the case for maintaining current regulations on i therapy floating microplastics and aggregate formation in the western mediterranean sea pe pp and ps the most abundant type of microplastics in mediterranean coastal waters dioxin tcdd induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations dioxin causes disease and reproductive problems across generations study finds cardiothoracic transplant recipient mycoplasma hominis an uncommon infection with probable donor transmission link found between donor infection in heart lung transplant recipients cross boundary human impacts compromise the serengeti mara ecosystem the serengeti mara squeeze one of the world s most iconic ecosystems under pressure circulating brain derived neurotrophic factor bdnf has diagnostic and prognostic value in traumatic brain injury. blood test predicts prognosis for traumatic brain injuries infantile spasms treated with the ketogenic diet prospective single center experience in consecutive infants high fat ketogenic diet effectively treats persistent childhood seizures study finds genome wide association study for acute otitis media in children identifies fndc as disease contributing gene gene found that raises risk of childhood ear infections quality of early maternal child relationship and risk of adolescent obesity quality of mother toddler relationship linked to teen obesity the genomic and transcriptomic landscape of a hela cell line havoc in biology s most used human cell line striking differences between hela genome and that of normal human cells predicted ground motions for great interface earthquakes in the cascadia subduction zone predicted ground motions for great earthquake in pacific northwest seattle victoria and vancouver reconciling taxon senescence with the red queen s hypothesis new interpretation of the red queen s hypothesis it s about expansion ultrasound molecular imaging of secreted frizzled related protein expression in murine angiosarcoma improved ultrasound imaging provides an alternative way of visualizing tumors prevention of injury and violence in the usa nearly percent of u.s. deaths in first three decades of life are due to unintentional injury or violence knock in reporter mice demonstrate that dna repair by non homologous end joining declines with age less effective dna repair process takes over as mice age evidence of a complex association between dose pattern and timing of prenatal alcohol exposure and child behaviour problems alcohol in pregnancy linked to child behavior problems impact of aspirin and non aspirin nonsteroidal anti inflammatory drugs on outcomes in patients with metastatic renal cell carcinoma use of ibuprofen and similar nsaids may shorten life of patients with metastatic renal cell carcinoma neighborhood collective efficacy parental spanking and subsequent risk of household child protective services involvement cohesive neighborhoods less spanking result in fewer child welfare visits prevalence of tobacco use and association between cardiometabolic risk factors and cigarette smoking in youth with type or type diabetes mellitus smoking widespread among youth with diabetes raising heart disease risk structural basis for simvastatin competitive antagonism of complement receptor effect of cholesterol medicine on inflammatory diseases mapped radiation treatment inhibits monocyte entry into the optic nerve head and prevents glaucoma in dba j mice targeted x ray treatment of mice prevents glaucoma reproductive factors and incidence of heart failure hospitalization in the women s health initiative timing of menopause onset may increase heart failure risk in women a model of integrative care for low back pain complementary and alternative medical therapy combined with conventional medical care may significantly improve treatment of lower back pain an integrated transcriptome atlas of embryonic hair follicle progenitors their niche and the developing skin hair gel online tool gives bird s eye view of hair follicle formation genome wide association study identifies three new melanoma susceptibility loci scientists discover three new gene faults which could increase melanoma risk by percent wnt a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice study identifies molecular signal for maintaining adult neuron effects of video game ownership on young boys academic and behavioral functioning a randomized controlled study game on ? video game ownership may interfere with young boys academic functioning oral articulatory control in childhood apraxia of speech movement tracking technology sheds light on different speech disorders in children service delivery and patient outcomes in ryan white hiv aids program funded and nonfunded health care facilities in the united states examining service delivery patient outcomes in ryan white hiv aids program efficacy safety and biomarkers of response to azacitidine and nivolumab in relapsed refractory acute myeloid leukemia a non randomized open label phase study combination chemotherapy and immunotherapy effective in phase ii leukemia study oral health of substance dependent individuals impact of specific substances most substance dependent individuals report poor oral health association of state laws permitting denial of services to same sex couples with mental distress in sexual minority adults religious refusal laws harm sexual minority mental health study finds characterization of the nanoscale structure of milk fat tasty fat x rays finding the blueprint of why fat is yummy towards a neurobehavioral profile of fetal alcohol spectrum disorders creating a preliminary neurobehavioral profile of fetal alcohol spectrum disorders ebselen alleviates testicular pathology in mice with zika virus infection and prevents its sexual transmission antioxidant treatment prevents sexual transmission of zika in mice a cold wet mid latitude environment on mars during the hesperian amazonian transition evidence from northern arabia valleys and paleolakes some ancient mars lakes formed long after others favl elevation in human tumors disrupts fanconi anemia pathway signaling and promotes genomic instability and tumor growth oncology fanconi anemia pathway dysregulated in non fa cancers a detached stellar mass black hole candidate in the globular cluster ngc odd behavior of star reveals lonely black hole hiding in giant star cluster fault tolerant logical gates in the ibm quantum experience code used to reduce quantum error in logic gates for first time the hairpin form of r g c exp in c als ftd is repeat associated non atg translated and a target for bioactive small molecules genetic cause of als and frontotemporal dementia blocked by rna binding compound induction of osteoarthritis and metabolic inflammation by a very high fat diet in mice effects of short term exercise exercise eases arthritis in obese mice even without weight loss prices costs and affordability of new medicines for hepatitis c in countries an economic analysis large global range of prices for hepatitis c medicines raises concerns about affordability asge endovators summit defining the role and value of endoscopic therapies in obesity management report from groundbreaking endovators summit offers guidance for obesity treatment defining terms for proactive management of resistance to bt crops and pesticides entomologists update definitions to tackle resistance to biotech crops pesticides dietary patterns and colorectal adenomas in lynch syndrome the geolynch cohort study snack attack eating unhealthy snack foods may affect cancer risk in patients with lynch syndrome epidemiological analyses of african swine fever in the european union november until november new model in the fight against african swine fever transcriptome analyses of the human retina identify unprecedented transcript diversity and. mb of novel transcribed sequence via significant alternative splicing and novel genes complete description of gene expression in the human retina neighborhood poverty urban residence race ethnicity and asthma rethinking the inner city asthma epidemic time to rethink the inner city asthma epidemic ? characterization of brain lesions in a mouse model of progressive multiple sclerosis diabetic mice provide a surprising breakthrough for multiple sclerosis research a possible second large subglacial impact crater in northwest greenland nasa finds possible second impact crater under greenland ice hematopoietic stem cells count and remember self renewal divisions stem cell memories may hold answer to their reproduction study finds randomized clinical trial of aspirin and simvastatin for pulmonary arterial hypertension asa stat size strength of heart s right side differs by age gender race ethnicity modeling the indirect economic implications of musculoskeletal disorders and treatment balancing act direct and indirect costs of managing musculoskeletal disorders migration strategy predicts stopover ecology in shorebirds on the northern gulf of mexico study finds migration strategy predicts stopover ecology in shorebirds slic is a surface displayed lipoprotein that is required for the anti lysozyme strategy during neisseria gonorrhoeae infection gonorrhea researchers identify novel route to vaccine new antibiotic causality of an extreme harmful algal bloom in monterey bay california during the northeast pacific warm anomaly what caused the most toxic algal bloom ever observed in monterey bay ? a human natural killer cell subset provides an innate source of il for mucosal immunity previously unknown immune cell may help those with crohn s and colitis cascading impacts of large carnivore extirpation in an african ecosystem ecologists find a landscape of fearlessness in a war torn savannah new developments in neuroscience can benefit the learning and performance of music how neuroscience can benefit the learning and performance of music deposition exhumation and paleoclimate of an ancient lake deposit gale crater mars wet paleoclimate of mars revealed by ancient lakes at gale crater five years later recovery from post traumatic stress and psychological distress among low income mothers affected by hurricane katrina hurricane katrina survivors struggle with mental health years later pharmacogenetic inhibition of eif e dependent mmp mrna translation reverses fragile x syndrome like phenotypes fragile x study offers hope of new autism treatment a single use self powered paper based sensor patch for detection of exercise induced hypoglycemia new self powered paper patch could help diabetics measure glucose during exercise the effects of a rise in cigarette price on cigarette consumption tobacco taxation revenues and of smoking related deaths in eu countries applying threshold regression modelling pay more smoke less possible effects of raising tobacco taxes across the eu reduction of abeta amyloid pathology in appps transgenic mice in the absence of gut microbiota gut bacteria may play a role in alzheimer s disease a line insertion in dlx is responsible for cleft palate and mandibular abnormalities in a canine model of pierre robin sequence cleft palate discovery in dogs to aid in understanding human birth defect a genetic association study of serum acute phase c reactive protein levels in rheumatoid arthritis implications for clinical interpretation crp genetic variants crucial in interpreting inflammatory disease activity phase i pharmacokinetic and pharmacodynamic study of chr an oral class i selective histone deacetylase inhibitor in refractory solid tumours next generation epigenetic cancer pill shown to be safe in phase i trial lactobacillus rhamnosus gg versus placebo for acute gastroenteritis in children probiotics no help to young kids with stomach virus long term effects of prenatal and infancy nurse home visitation on the life course of youths year follow up of a randomized trial nurse home visitation program reduces girls potential criminality later in life ancient dna reveals the chronology of walrus ivory trade from norse greenland lost norse of greenland fueled the medieval ivory trade ancient walrus dna suggests targeted gadofullerene for sensitive magnetic resonance imaging and risk stratification of breast cancer mri contrast agent locates and distinguishes aggressive from slow growing breast cancer foxp t cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis in the gut immunity is a two way street complex role of gut bacteria evaluating environmental and climatic influences on nesting in leatherback sea turtles dermochelys coriacea in st. kitts west indies leatherback sea turtles choose nest sites carefully study finds social networks social support and burden in relationships and mortality after breast cancer diagnosis in the life after breast cancer epidemiology lace study fun and friends help ease the pain of breast cancer formulating propranolol as an amorphous melt affords reduced skin irritation potential for transdermal drug delivery liquid salts deliver drugs through the skin with enhanced efficacy reduced toxicity differential contributions of polycystic ovary syndrome pcos manifestations to psychological symptoms psychiatric complications in women with polycystic ovary syndrome most often linked to menstrual irregularities a mesoporous silica biomaterial for dental biomimetic crystallization a potential long lasting treatment for sensitive teeth optogenetic neuronal stimulation promotes functional recovery after stroke targeted brain stimulation aids stroke recovery in mice scientists find one year outcomes in caregivers of critically ill patients caregivers of icu survivors at high risk of developing depression emotional distress neuropeptide y receptor genes are associated with alcohol dependence alcohol withdrawal phenotypes and cocaine dependence neuropeptide y system linked to more severe form of alcohol dependence biogeochemical conditions determine virulence of black band disease in corals chemical microgradients accelerate coral death at the great barrier reef low dose effects of bisphenol a on mammary gland development in rats bisphenol a in low doses can affect the reproductive system behavior mri evidence of neuropathic changes in former college football players thinning of brain tissue remains in college football players five years after play social interaction in infants learning of second language phonetics an exploration of brain behavior relations babies brains show that social skills linked to second language learning community surveillance of respiratory viruses among families in the utah better identification of germs longitudinal viral epidemiology big love study viruses thrive in big families in sickness and in health the accuracy of noninvasive hemoglobin monitoring using the radical pulse co oximeter in children undergoing neurosurgery noninvasive technique can help in monitoring hemoglobin during surgery in children sub optimal cholesterol response to initiation of statins and future risk of cardiovascular disease half of patients on statins fail to reach healthy cholesterol level after years prevalence of advanced precancerous colorectal neoplasms in black and white populations a systematic review and meta analysis racial differences in colorectal cancer incidence not due to biology seasonal and life stage variation in the reproductive ecology of a marine apex predator the tiger shark galeocerdo cuvier at a protected female dominated site scientists used high tech ultrasound imaging to study tiger shark reproduction genetic ancestry of families of putative inka descent genetics of the modern heirs of the inkas shed new lights about their origins and lineages the use of variance decomposition in the investigation of ceo effects how large must the ceo effect be to rule out chance ? ceo effect on firm performance mostly due to chance climate driven build up of temporal isolation within a recently formed avian hybrid zone the likelihood for mixed breeding between two songbird species lessens with warmer springs diel population and functional synchrony of microbial communities on coral reefs bacteria surrounding coral reefs change in synchrony even across great distance high stakes choice achievement and accountability in the nation s oldest urban voucher program public oversight improves test scores in voucher schools a brain phenotype for stressor evoked blood pressure reactivity brain activity may be predictor of stress related cardiovascular risk surrogate estimates of insulin sensitivity in obese youth along the spectrum of glucose tolerance from normal to prediabetes to diabetes vitamin d deficiency is associated with different types of obesity in black and white children population genetic structure and evolutionary history of bale monkeys chlorocebus djamdjamensis in the southern ethiopian highlands bale monkeys living in different areas have very different dna heat related morbidity and mortality in new england evidence for local policy as heat index climbs emergency visits deaths rise in new england discontinuation of statin therapy associates with parkinson disease a population based study stopping cholesterol drugs may be associated with increased risk of parkinson s three dimensional epithelial tissues generated from human embryonic stem cells skin like tissue developed from human embryonic stem cells taxonomic revision of mcvaughia w.r.anderson malpighiaceae notes on vegetative and reproductive anatomy and the description of a new species brazil endemic plant genus mcvaughia highlights diversity in a unique biome the antagonistic gene paralogs upf a and upf b govern nonsense mediated rna decay underappreciated protein plays critical role in rna regulation male fertility preclinical efficacy studies in investigator brochures do they enable risk benefit assessment ? human drug trials are compromised by poor reporting of animal research surgical or transcatheter aortic valve replacement in intermediate risk patients self expanding tavr as good as surgery in intermediate risk patients evaluating the usability of a wearable social skills training technology for children with autism spectrum disorder google glass app helps autistic children with social interactions rapid and efficient induction of functional astrocytes from human pluripotent stem cells new method grows brain cells from stem cells quickly and efficiently do minimum wages improve early life health ? evidence from developing countries impact of minimum wage on child health varies steroid hormone induction of temporal gene expression in drosophila brain neuroblasts generates neuronal and glial diversity hormone key to brain development in fruit flies identified motivating cord blood donation with information and behavioral nudges stem cell rich cord blood donations could increase by nudging parents study suggests ppar is a nexus controlling alternative activation of macrophages via glutamine metabolism diabetes drugs act as powerful curb for immune cells in controlling inflammation assessing the genetics content in the next generation science standards science educators analyze genetics content of next generation science standards vulnerability of arctic marine mammals to vessel traffic in the increasingly ice free northwest passage and northern sea route marine mammals most at risk from increased arctic ship traffic an acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss regenerative medicine approach improves muscle strength function in leg injuries derived from pig bladder association of childhood oral infections with cardiovascular risk factors and subclinical atherosclerosis in adulthood common oral infections in childhood may increase the risk of atherosclerosis in adulthood how grammatical choice shapes media representations of climate un certainty reporters using more hedging words in climate change articles synthesis of customized petroleum replica fuel molecules by targeted modification of free fatty acid pools in escherichia coli special e. coli bacteria produce diesel on demand stability of active mantle upwelling revealed by net characteristics of plate tectonics location of upwelling in earth s mantle discovered to be stable structure of the type iva major pilin from the electrically conductive bacterial nanowires of geobacter sulfurreducens structure of bacterial nanowire protein hints at secrets of conduction efficacy of tramadol extended release for opioid withdrawal clinical trial looks at tramadol for opioid withdrawal effects of land use and climate change on groundwater and ecosystems at the middle reaches of the tarim river using the mike she integrated hydrological model last chance for oasis in china s desert variations in angiosperm leaf vein density have implications for interpreting life form in the fossil record plant life forms in the fossil record when did the first canopy flowers appear ? familial risk and heritability of cancer among twins in nordic countries twin study estimates familial risks of different cancers economic effects of smoke free laws on rural and urban counties in kentucky and ohio smoke free laws don t impact rural or urban economies sociability deficits and altered amygdala circuits in mice lacking pcdh an autism associated gene mouse model points to potential drug target for increasing social interaction in autism linking global hiv aids treatments with national programs for the control and elimination of the neglected tropical diseases evidence shows ntd control can help in the fight against hiv aids soilborne fungi have host affinity and host specific effects on seed germination and survival in a lowland tropical forest tropical diversity takes root in relationships between fungi and seeds increased risk of developing breast cancer after a false positive screening mammogram false positive mammograms may indicate increased risk of breast cancer later impact of smoking and smoking cessation on cardiovascular events and mortality among older adults meta analysis of individual participant data from prospective cohort studies of the chances consortium quit smoking at age lower risk for heart attack and stroke within the first five years cannabis in pain treatment clinical and research considerations experts off guidance on medical marijuana for pain midlife coffee and tea drinking and the risk of late life dementia a population based caide study midlife coffee and tea drinking may protect against late life dementia education modifies the association of wealth with obesity in women in middle income but not low income countries an interaction study using seven national datasets education protects poor women from fattening effects of rising wealth humans store about. megabytes of information during language acquisition kids store. megabytes of information to master their native language combined zebrafish yeast chemical genetic screens reveal gene copper nutrition interactions that modulate melanocyte pigmentation new screen offers hope for copper deficiency sufferers differences in research funding for women scientists a systematic comparison of uk investments in global infectious disease research during uk women scientists have fewer studies funded given less money than men cytonuclear discordance in the florida everglades invasive burmese python python bivittatus population reveals possible hybridization with the indian python p. molurus genetic analysis of florida s invasive pythons reveals a tangled family tree evidence for igneous differentiation in sudbury igneous complex and impact driven evolution of terrestrial planet proto crusts ancient asteroid impacts played a role in creation of earth s future continents high level clonal fgfr amplification and response to fgfr inhibition in a translational clinical trial blood test supports use of potential new treatment for patients with stomach cancer conformational dynamics of single hiv envelope trimers on the surface of native virions dynamic motion of hiv as it readies an attack seen in real time for the first time human amniocytes are receptive to chemically induced reprogramming to pluripotency gene key for chemically reprogramming human stem cells successful treatment of postchemotherapy azoospermia with microsurgical testicular sperm extraction the weill cornell experience surgical technique helps adult male survivors of childhood cancer regain fertility increased gene copy number of vamp disrupts human male urogenital development through altered estrogen action new genetic cause of male reproductive birth defects identified creating complex molecular topologies by configuring dna four way junctions unraveling knotty chemical structures enables rapid screening of anti cancer compounds gene flow between wolf and shepherd dog populations in georgia caucasus wolves at the door study finds recent wolf dog hybridization in caucasus region postnatal loss of p q type channels confined to rhombic lip derived neurons alters synaptic transmission at the parallel fiber to purkinje cell synapse and replicates genomic cacna a mutation phenotype of ataxia and seizures in mice dysfunction in cerebellar calcium channel causes motor disorders and epilepsy shorter telomere length in cord blood associated with prenatal air pollution exposure benefits of intervention air pollution may shorten telomeres in newborns a sign of increased health risks breakthrough of the year hiv treatment as prevention hiv study named breakthrough of the year by science egf signaling directs neoblast repopulation by regulating asymmetric cell division in planarians key molecular signal that shapes regeneration in planarian stem cells discovered patterns of cognitive decline prior to dementia in persons with mild cognitive impairment identifying typical patterns in the progression towards alzheimer s disease hemodynamic forces tune the arrest adhesion and extravasation of circulating tumor cells blood flow is a major influence on tumor cell metastasis sharad detection and characterization of subsurface water ice deposits in utopia planitia mars mars ice deposit holds as much water as lake superior the impact of a reported penicillin allergy on surgical site infection risk reported penicillin allergy appears to increase the risk of surgical site infections a case series on the effects of kripalu yoga for generalized anxiety disorder yoga may be viable option for people with generalized anxiety disorder climate driven geographic distribution of the desert locust during recession periods subspecies niche differentiation and relative risks under scenarios of climate change desert locusts new risks in the light of climate change pebp wardens ferroptosis by enabling lipoxygenase generation of lipid death signals tracing cell death pathway points to drug targets for brain damage kidney injury asthma occurrence and distribution of uv filters and other anthropogenic contaminants in coastal surface water sediment and coral tissue from hawaii new study measures uv filter chemicals in seawater and corals from hawaii associations between midlife vascular risk factors and year incident dementia in the atherosclerosis risk in communities aric cohort midlife cardiovascular risk factors may increase chances of dementia new highly diverse hepatitis c strains detected in sub saharan africa have unknown susceptibility to direct acting antiviral treatments new strains of hepatitis c found in africa innate olfactory preferences for flowers matching proboscis length ensure optimal energy gain in a hawkmoth scent guides hawk moths to the best fitting flowers immune evasion of plasmodium falciparum by rifin via inhibitory receptors discovery of key molecules involved in severe malaria exposure to influenza virus aerosols during routine patient care patients can emit small influenza containing particles into the air during routine care angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies results of the promisse study biomarkers in maternal blood can identify pregnant women with lupus at low risk for adverse outcomes preadolescent decision making competence predicts interpersonal strengths and difficulties a year prospective study child s poor decision making skills can predict later behavior problems research shows experimental and natural warming elevates mercury concentrations in estuarine fish warmer oceans could raise mercury levels in fish human limbal biopsy derived stromal stem cells prevent corneal scarring patient s own stem cells could clear a cloudy cornea study shows a non human primate model for urinary bladder regeneration utilizing autologous sources of bone marrow derived mesenchymal stem cells bladder regeneration using stem cells from patients own bone marrow dynamics of a large restless rhyolitic magma system at laguna del maule southern andes chile exploring a large restless volcanic field in chile hiv intron containing rna expression induces innate immune activation and t cell dysfunction hiv rna expression inhibitors may restore immune function in hiv infected individuals inhaled oxytocin increases positive social behaviors in newborn macaques oxytocin promotes social behavior in infant rhesus monkeys predicting gaze in egocentric video by learning task dependent attention transition snapshots of the future tool learns to predict user s gaze in headcam footage hongyacha a naturally caffeine free tea plant from fujian china a newly discovered naturally low caffeine tea plant d geometry of a plate boundary fault related to the off mie earthquake in the nankai subduction zone japan japanese earthquake zone strongly influenced by the effects of friction locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia disorder in gene control system is a defining characteristic of cancer study finds dsyb catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton scientists discover key gene for producing marine molecule with huge environmental impacts mitochondrial ca uniporter is a mitochondrial luminal redox sensor that augments mcu channel activity moonlighting function for mitochondrial calcium influx machinery mcu complex decreased lung function in year old children with early life organophosphate exposure weaker breaths in kids linked to early pesticide exposure binocular vision and eye movement disorders in older adults age general health antidepressant use linked to eye disorders macromolecular organic compounds from the depths of enceladus scientists find evidence of complex organic molecules from enceladus targeting cellular senescence prevents age related bone loss in mice link between cells associated with aging bone loss microrna b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer likely key driver of colorectal cancer development progression immediate versus delayed quitting and rates of relapse among smokers treated successfully with varenicline bupropion sr or placebo stopping smoking cessation treatments too soon may reduce odds of success for percent of smokers systematic review of traumatic brain injuries in baseball and softball a framework for prevention review finds poor compliance with helmet use in baseball and softball pravastatin improves pregnancy outcomes in obstetric antiphospholipid syndrome refractory to antithrombotic therapy statins improve birth outcomes for mothers with an autoimmune disorder neurodegenerative disease concomitant proteinopathies are prevalent age related and apoe associated rethinking neurodegenerative disease treatment target multiple pathological proteins which moral foundations predict willingness to make lifestyle changes to avert climate change in the usa ? moral values influence level of climate change action a population based study of paediatric emergency department and office visits for concussions from to significant increase in concussions among ontario children youth study finds crocodyliform feeding traces on juvenile ornithischian dinosaurs from the upper cretaceous campanian kaiparowits formation utah new dinosaur species first fossil evidence shows small crocs fed on baby dinosaurs the healthy aging brain care habc monitor validation of the patient self report version of the clinical tool designed to measure and monitor cognitive functional and psychological health patient self reporting version of blood pressure cuff for dementia is reliable valid prognostic microrna mrna signature from the integrated analysis of patients with invasive breast cancer big data analysis identifies prognostic rna markers in a common form of breast cancer proinvasion metastasis drivers in early stage melanoma are oncogenes early stage melanoma tumors contain clues to metastatic potential an immuno wall microdevice exhibits rapid and sensitive detection of idh r h mutation specific to grade ii and iii gliomas new device enables rapid identification of brain cancer type and tumor margin morphinan biosynthesis in opium poppy requires a p oxidoreductase fusion protein genetic discovery uncovers key tool for morphine production in poppies an assessment of optokinetic nystagmus okn in persons with down syndrome altered cerebella found in those with down syndrome accounts for poor motor skills coordination microbiota dependent crosstalk between macrophages and ilc promotes intestinal homeostasis deficient protein gm csf production found to impair gut s immune tolerance how does the environment affect fighting ? the interaction between extrinsic fighting ability and resource value during contests oxygen levels impact on species ability and willingness to fight cannabis use moderates the relationship between pain and negative affect in adults with opioid use disorder marijuana use may not aid patients in opioid addiction treatment primary prevention with lipid lowering drugs and long term risk of vascular events in older people population based cohort study cholesterol drugs associated with percent lower stroke risk in healthy older adults a small rna catalytic argonaute pathway tunes germline transcript levels to ensure embryonic divisions for the perfect eggs roundworms use small rnas c orf frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense rna foci rna build up linked to dementia motor neuron disease rapid dispersion of syngap from synaptic spines triggers ampa receptor insertion and spine enlargement during ltp brain scientists figure out how a protein crucial to learning and memory works yield labor and fruit and juice quality characteristics of machine and hand harvested brown snout specialty cider apple machine harvesting may increase apple supply for hard cider market vaccine elicitation of high mannose dependent neutralizing antibodies against the v glycan broadly neutralizing epitope in nonhuman primates researchers map pathways to protective antibodies for an hiv vaccine elicitation of structure specific antibodies by epitope scaffolds scientists freeze virus fragment in shape recognized by immune system development has implications for vaccine design self administered outpatient antimicrobial infusion by uninsured patients discharged from a safety net hospital a propensity score balanced retrospective cohort study patients can safely self administer long term iv antibiotics reducing hospital stays early non invasive detection of breast cancer using exhaled breath and urine analysis new breath and urine tests detect early breast cancer more accurately two massive rapid releases of carbon during the onset of the palaeocene eocene thermal maximum past global warming similar to today s size duration were like modern climate shift but in two pulses intervention targeting development of socially synchronous engagement in toddlers with autism spectrum disorder a randomized controlled trial toddlers with autism show improved social skills following targeted intervention depletion of microglia and inhibition of exosome synthesis halt tau propagation researchers discover role of microglia during early progression of alzheimer s disease population structure of humpback whales from their breeding grounds in the south atlantic and indian oceans whale sized genetic study largest ever for southern hemisphere humpbacks a pediatric asthma risk score to better predict asthma development in young children scientists create most accurate tool yet developed to predict asthma in young children evidence for the effectiveness of a national school based mental health program in chile national school based mental health intervention improves outcomes for at risk students a human gut microbial gene catalogue established by metagenomic sequencing bacterial balance keeps us healthy microbial genes in gut outnumber genes in human body does high dose antimicrobial chemotherapy prevent the evolution of resistance ? what is the optimal dose of medication to prevent the evolution of drug resistance ? grape seed extract dose responsively decreases disease severity in a rat model of mucositis concomitantly enhancing chemotherapeutic effectiveness in colon cancer cells grape seed promise in fight against bowel cancer market reactions to policy deliberations on fair value accounting and impairment rules during the financial crisis of new insights on the factors that intensified the financial crisis perfusion neuroimaging abnormalities alone distinguish national football league players from a healthy population abnormally low blood flow indicates damage to nfl players brains differential inhibition of metabolite amyloid formation by generic fibrillation modifying polyphenols compounds found in green tea and red wine may block formation of toxic metabolites phase trial of erlotinib combined with cisplatin and radiotherapy in patients with locally advanced cervical cancer targeted drug may prolong survival of patients with cervical cancer the broad spectrum antiviral favipiravir protects guinea pigs from lethal lassa virus infection post disease onset antiviral favipiravir successfully treats lassa virus in guinea pigs a histone acetylome wide association study of alzheimer s disease identifies disease associated h k ac differences in the entorhinal cortex losing control of gene activity in alzheimer s disease should women applicants man up for traditionally masculine fields ? effectiveness of two verbal identity management strategies should women man up for male dominated fields ? therapeutic effect of streptococcus thermophilus crl fermented milk on chronic gastritis therapeutic effect of fermented milk on chronic gastritis comorbid conditions explain the association between posttraumatic stress disorder and incident cardiovascular disease ptsd alone didn t increase heart disease risk in veterans with ptsd effects of maternal nicotine exposure on thyroid hormone metabolism and function in adult rat smoking while breastfeeding puts children at risk of obesity later in life esmo consensus guidelines for the management of patients with metastatic colorectal cancer new consensus guidelines on the management of metastatic colorectal cancer climate driven introduction of the black death and successive plague reintroductions into europe asian tree rings explain historical plague outbreaks in europe volcanic contribution to emergence of central panama in the early miocene volcanic growth critical to the formation of panama real world outcomes in psoriasis patients one in five has pasi and or dlqi under ongoing systemic therapy treatment has no sufficient effect in one of five psoriasis patients cholesterol efflux capacity high density lipoprotein function and atherosclerosis new measure trumps high density lipoprotein hdl levels in protecting against heart disease a biobank of breast cancer explants with preserved intra tumor heterogeneity to screen anticancer compounds new way of testing drugs could speed up development of breast cancer treatments association of warfarin use with lower overall cancer incidence among patients older than years is anticoagulant warfarin associated with lower risk of cancer incidence ? state gun law environment and youth gun carrying in the united states study examines gun control policies effect on youth gun carrying vascular rage transports oxytocin into the brain to elicit its maternal bonding behaviour in mice elucidation of functional mechanism of love hormone oxytocin at molecular level biochemical and functional characterization of glycosylation associated mutational landscapes in colon cancer three glycosyltransferases identified as significant mutational targets in colon cancer scheduling and shift work characteristics associated with risk for occupational injury in newly licensed registered nurses an observational study working overtime managing a large workload increases risk for injury among new nurses peripheral arteries may be reliable indicators of coronary vascular disease assessing heart disease risk is within arm s reach sexual transmission of oral human papillomavirus infection among men oral cancer causing hpv may spread through oral genital routes conventional citrus of some scion rootstock combinations show field tolerance under high huanglongbing disease pressure citrus scion rootstock combinations show tolerance to huanglongbing determinants of medicare costs for elderly patients with oral cavity and pharyngeal cancers what are medicare costs for patients with oral cavity pharyngeal cancers ? risk factors for recent nonfatal overdose among hiv infected russians who inject drugs study identifies risk factors for non fatal overdoses transient rapamycin treatment can increase lifespan and healthspan in middle aged mice brief rapamycin therapy in middle aged mice extends lives record breaking warming and extreme drought in the amazon rainforest during the course of el ni o el ni o global warming combine to cause extreme drought in amazon rainforest vitamin d levels and susceptibility to asthma elevated immunoglobulin e levels and atopic dermatitis a mendelian randomization study vitamin d levels not linked to asthma or dermatitis prodigious submarine landslides during the inception and early growth of volcanic islands the planet s largest landslides happen on submarine volcanoes household net worth racial disparities and hormonal therapy adherence among women with early stage breast cancer disparities in breast cancer care linked to net worth a mighty claw pinching force of the coconut crab the largest terrestrial crustacean coconut crab claws pinch with the strongest force of any crustacean dna defects epigenetics and gene expression in cancer adjacent breast a study from the cancer genome atlas researchers link gene expression patterns of normal tissue to breast cancer prognosis the political agency of royal women a comparative analysis of eight premodern states according to societal rules and roles at last acknowledging royal women s political power a model sea urchin spicule matrix protein rspsm is a hydrogelator that modifies and organizes the mineralization process sea urchin protein provides insights into self assembly of skeletal structures whole exome sequencing reveals mutations in hemophagocytic lymphohistiocytosis and macrophage activation syndrome linked genes in fatal cases of h n influenza genetic risk for hyperinflammatory disorder from viral infection identified use of alternative medicine for cancer and its impact on survival using alternative medicine only for cancer linked to lower survival rate effect of teledermatology on access to dermatology care among medicaid enrollees teledermatology linked to access to dermatologists for medicaid enrollees in california optimal strategies for estimating the average fidelity of quantum gates new results make development of quantum computers more realistic case report conjunctival infestation with thelazia gulosa a novel agent of human thelaziasis in the united states oregon woman first known case of human infected with cattle eyeworm species axonal loss in the multiple sclerosis spinal cord revisited loss of spinal nerve fibers not the only cause of disability in multiple sclerosis first discovery of adventive populations of trissolcus japonicus in europe first discovery of adventive populations of trissolcus japonicus modeling a genetic risk for schizophrenia in ipscs and mice reveals neural stem cell deficits associated with adherens junctions and polarity new strategy could uncover genes at the root of psychiatric illnesses alcohol consumption alcohol outlets and the risk of being assaulted with a gun reducing gun violence by addressing heavy drinking and off premise alcohol outlets impact of urine drug screening on no shows and dropouts among chronic pain patients a propensity matched cohort study research finds no easy answers to use of drug screening for pain patients ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility stem cell researcher targets seeds of breast cancer metastasis the earliest direct evidence of frogs in wet tropical forests from cretaceous burmese amber amber fossils provide oldest evidence of frogs in wet tropical forests hikurangi margin tsunami earthquake generated by slow seismic rupture over a subducted seamount extinct undersea volcanoes squashed under earth s crust cause tsunami earthquakes treatment of human glioblastoma with a live attenuated zika virus vaccine candidate zika vaccine shows promise for treating deadly brain cancer working age adults with diabetes experience greater susceptibility to seasonal influenza a population based cohort study study backs giving flu vaccine to working age adults with diabetes nonmedical opioid use and heroin use in a nationally representative sample of us high school seniors of high school heroin users started with prescription opioids severely deficient autobiographical memory sdam in healthy adults a new mnemonic syndrome middle aged adults lacking vivid memories living life in the third person involuntary and voluntary electroconvulsive therapy a case control study people undergoing voluntary and involuntary ect treatment have similar outcomes proportion of osteoporotic women remaining at risk for fracture despite adherence to oral bisphosphonates study finds one third of women taking bisphosphonates remain at risk for fracture fully textured monolithic perovskite silicon tandem solar cells with. power conversion efficiency solar cells combining silicon with perovskite have achieved record efficiency of. percent d chromosome regulatory landscape of human pluripotent cells d map of human genome reveals relationship between mutations and disease development the containment of potential outbreaks triggered by imported chikungunya cases in italy a cost utility epidemiological assessment of vector control measures mosquito borne diseases in europe containment strategy depends on when the alarm sets off magnetic flux rope shredding by a hyperbolic flux tube the detrimental effects of magnetic topology on solar eruptions nasa watches the sun put a stop to its own eruption a walnut enriched diet reduces the growth of lncap human prostate cancer xenografts in nude mice prostate cancers are fewer smaller on walnut enriched diet identification of a contact zone and hybridization for two subspecies of the american pika ochotona princeps within a single protected area new evidence of two subspecies of american pikas in rocky mountain national park the burden of loss unexpected death of a loved one and psychiatric disorders across the life course in a national study unexpected death of a loved one linked to onset of psychiatric disorders effects of cold stress and heat stress on coral fluorescence in reef building corals fluorescent light revealed as gauge of coral health mysterious glow of light found to correlate with coral stress prior to bleaching global spread of hypoxia in freshwater ecosystems during the last three centuries is caused by rising local human pressure human activities trigger hypoxia in freshwaters around the globe intranasal administration of mesenchymoangioblast derived mesenchymal stem cells abrogates airway fibrosis and airway hyperresponsiveness associated with chronic allergic airways disease unique stem cells as a potential asthma treatment people in sub saharan africa rate their health and health care among the lowest in the world sub saharan africans rate their well being and health care among the lowest in the world plab and uk graduates performance on mrcp uk and mrcgp examinations data linkage study experts call for higher exam pass marks to close performance gap between international uk medical graduates dietary walnut altered gene expressions related to tumor growth survival and metastasis in breast cancer patients a pilot clinical trial scientists tie walnuts to gene expressions related to breast cancer combined speeds of climate and land use change of the conterminous us until double threat of climate and land use change enhances risks to biodiversity arcn mutations cause a recognizable craniofacial syndrome due to copi mediated transport defects new genetic syndrome tied to defects in protein transport projected changes in persistent extreme summer weather events the role of quasi resonant amplification controlling future summer weather extremes still within our grasp depressed mood predicts pulmonary rehabilitation completion among women but not men effect of depressed mood on pulmonary rehab completion observing storytellers who use rhythmic beat gestures improves children s narrative discourse performance. telling stories using rhythmic gesture helps children improve their oral skills use and effectiveness of quitline versus web based tobacco cessation interventions among four state tobacco control programs study compares effectiveness of phone based and web based smoking cessation programs in four states on demand preexposure prophylaxis in men at high risk for hiv infection taking truvada as needed can prevent hiv transmission amongst people at high risk recyclable organic solar cells on cellulose nanocrystal substrates trees used to create recyclable efficient solar cell stromal gene expression defines poor prognosis subtypes in colorectal cancer discovery of genetic fingerprint of aggressive colon tumors a new high resolution radiocarbon bayesian age model of the holocene and late pleistocene from core md and others effingham inlet british columbia canada with an application to the paleoseismic event chronology of the cascadia subduction zone when will the next megathrust hit the west coast of north america ? enhanced t cell recovery in hiv infected adults through il treatment combination therapy restores t cell numbers in hiv infected individuals an integrated network of androgen receptor polycomb and tmprss erg gene fusions in prostate cancer progression gene fusions may be the smoking gun in prostate cancer development the emergent role of small bodied herbivores in pre empting phase shifts on degraded coral reefs are tiny grazers the new hope for caribbean reefs ? targeted sequencing identifies neurodevelopmental disorder risk genes with autism and developmental disability biases sorting out risk genes for brain development disorders up to corn germ may be included in diets fed to growing finishing pigs without affecting pig growth performance carcass composition or pork fat quality feeding corn germ to pigs does not affect growth performance it is time to reevaluate the management of patients with brain metastases to advance care for patients with brain metastases reject five myths old age associated phenotypic screening for alzheimer s disease drug candidates identifies sterubin as a potent neuroprotective compound from yerba santa native california medicinal plant may hold promise for treating alzheimer s intraoperative brain cancer detection with raman spectroscopy in humans revolutionary new probe zooms in on cancer cells multiple mechanisms influencing the relationship between alcohol consumption and peer alcohol use genes environment contribute to personal peer drinking during adolescence and beyond inhibition of mammalian target of rapamycin signaling with rapamycin prevents trauma induced heterotopic ossification rapamycin treatment prevents crippling abnormal bone formation after severe limb injuries two year olds can begin to acquire verb meanings in socially impoverished contexts toddlers can learn verbs even in non social contexts oncogenic hijacking of the stress response machinery in t cell acute lymphoblastic leukemia hijacked cell response to stress reveals promising drug targets for blood cancer escherichia coli translation strategies differ across carbon nitrogen and phosphorus limitation conditions researchers discover the optimism of e. coli bacteria global burden of severe periodontitis in a systematic review and meta regression severe periodontitis sixth most prevalent health condition in the world simplifying the use of prognostic information in traumatic brain injury. part the gcs pupils score an extended index of clinical severity brain trauma new glasgow coma scale pupils score and multifactor probability outcome charts china s caesarean delivery rate is it too high ? is china s percent cesarean section delivery rate too high ? gestational diabetes associated with incident diabetes in childhood and youth a retrospective cohort study maternal gestational diabetes linked to diabetes in children effect of fireworks events on urban background trace metal aerosol concentrations is the cocktail worth the show ? smoke from fireworks is harmful to health study suggests distinct factors control histone variant h. localization at specific genomic regions scientists track variant of gene regulating protein in embryonic stem cells rapid acclimation of juvenile corals to co mediated acidification by up regulation of hsp and bcl genes a glimmer of hope for corals as baby reef builders cope with acidifying oceans the pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression gut bacteria determine speed of tumor growth in pancreatic cancer weaker land climate feedbacks from nutrient uptake during photosynthesis inactive periods improving climate models to account for plant behavior yields goodish news optimizing the influence of social norms interventions applying social identity insights to motivate residential water conservation highlighting social identity and peer group norms can increase water conservation a new genus and species of heron aves ardeidae from the late miocene of florida museum volunteers discover new species of extinct heron at north florida fossil site the citrus route revealed from southeast asia into the mediterranean citrus fruits were the clear status symbols of the nobility in the ancient mediterranean substantial improvements not seen in health behaviors following corner store conversions in two latino food swamps healthy eating gets no boost after corner store interventions study finds multipotent adult progenitor cells prevent macrophage mediated axonal dieback and promote regrowth after spinal cord injury regenerative benefit of multistem after spinal cord injury demonstrated targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging peptide targeting senescent cells restores stamina fur and kidney function in old mice dental calculus reveals unique insights into food items cooking and plant processing in prehistoric central sudan tooth plaque provides unique insights into our prehistoric ancestors diet low normalized grip strength is a biomarker for cardiometabolic disease and physical disabilities among u.s. and chinese adults weak grip a strong predictor of metabolic disease and disability in adults spectral diversity and regulation of coral fluorescence in a mesophotic reef habitat in the red sea rainbow of glowing corals discovered in depths of the red sea flipper driven terrestrial locomotion of a sea turtle inspired robot flipperbot sea turtles and flipper driven robot reveal principles of moving on sand and other granular media retirement timing of women and the role of care responsibilities for grandchildren link between arrival of grandchildren early retirement of women prestimulus inhibition of saccades in adults with and without attention deficit hyperactivity disorder as an index of temporal expectations eye movements reveal temporal expectation deficits in adhd mir suppresses brain metastasis of breast cancer stem like cells by modulating klf microrna molecule may serve as biomarker target for brain metastases in breast cancer patients flavorings in tobacco products induce endothelial cell dysfunction tobacco aside e cigarette flavorings may harm blood vessels dietary behaviour of man eating lions as revealed by dental microwear textures the tale teeth tell about the legendary man eating lions of tsavo distance to invasive heart centre performance of acute coronary angiography and angioplasty and associated outcome in out of hospital cardiac arrest a nationwide study cardiac arrest patients do better if taken immediately to a specialist heart center compartmental analysis of metals in waterpipe smoking technique up in smoke belief that shisha pipe filters out heavy metals american cancer society american society of clinical oncology breast cancer survivorship care guideline new guideline addresses long term needs of breast cancer survivors distance dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus rhythm of memory inhibited neurons set tempo for memory processes mosquito saliva increases endothelial permeability in the skin immune cell migration and dengue pathogenesis during antibody dependent enhancement mosquito saliva increases disease severity following dengue virus infection single cell rna seq supports a developmental hierarchy in human oligodendroglioma single cell analysis supports a role for cancer stem cells in brain tumor growth greater ecosystem carbon in the mojave desert after ten years exposure to elevated co arid areas absorb unexpected amounts of atmospheric carbon full annual cycle population models for migratory birds full annual cycle models track migratory bird populations throughout the year cyp a loss dysregulates cholesterol homeostasis in prostate cancer prostate cancer cells grow with malfunction of cholesterol control in cells insurance status affects postoperative morbidity and complication rate after shoulder arthroplasty insurance status impacts complication rates after shoulder replacement surgery immobilization of microalgae on exogenous fungal mycelium a promising separation method to harvest both marine and freshwater microalgae using fungi to catch algae harvesting microalgae for fuels and chemicals production temporal changes in the incidence of treated psychiatric and neurodevelopmental disorders during adolescence an analysis of two national finnish birth cohorts increasing number of adolescents receive a psychiatric or neurodevelopmental diagnosis why do parents who usually vaccinate their children hesitate or refuse ? general good vs. individual risk why do parents who usually vaccinate their children hesitate or refuse ? effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea a double blind randomised controlled trial value of oxygen therapy in end of life care challenged in new study physicians perception of guideline recommended low density lipoprotein target values characteristics of misclassified patients doctors are failing to lower heart patients cholesterol adequately european study finds regular physical activity a magic bullet for the pandemics of obesity and cardiovascular disease regular physical activity is magic bullet for pandemics of obesity cardiovascular disease discovery of a three dimensional topological dirac semimetal na bi natural d counterpart to graphene discovered new form of quantum matter faithful fathers and crooked cannibals the adaptive significance of parental care in the bush frog raorchestes chalazodes western ghats india devoted frog fathers guard their eggs from predators galantamine alleviates inflammation and insulin resistance in patients with metabolic syndrome in a randomized trial alzheimer s drug cuts hallmark inflammation related to metabolic syndrome by percent hockey star a methodology for assessing the biomechanical performance of hockey helmets only one of hockey helmets tested earn star rating physiologically persistent corpora lutea in eurasian lynx lynx lynx longitudinal ultrasound and endocrine examinations intra vitam the eurasian lynx as a key to the conservation and future viability of the endangered iberian lynx cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria lipidomic evidence supporting the warburg theory of cancer nearly a century later new findings support warburg theory of cancer interventions for preventing excessive weight gain during pregnancy is eating for two a good idea ? maintaining a healthy weight during pregnancy helps mother and baby environmental persistence of a highly pathogenic avian influenza h n virus highly pathogenic bird flu virus can survive months on steel or glass at cooler temperatures distinct mechanisms eliminate mother and daughter centrioles in meiosis of starfish oocytes mothers and daughters how starfish egg cells eliminate crucial structures to ensure the embryo will be viable panel based genetic diagnostic testing for inherited eye diseases is highly accurate and reproducible and more sensitive for variant detection than exome sequencing panel based genetic diagnostic testing for inherited eye diseases is highly accurate more sensitive than exome sequencing nonfasting triglycerides and risk of ischemic stroke in the general population increased nonfasting triglyceride levels associated with higher risk of stroke changes in georgia restaurant and bar smoking policies from to smoking allowed in growing number of restaurants bars in georgia the relationship between brand specific alcohol advertising on television and brand specific consumption among underage youth brand specific television alcohol ads a significant predictor of brand consumption among underage youth long term risk of cardiovascular disease in women who have had infants with heart defects heart defects in infant may predict heart problems in birth mother later in life global patterns of extinction risk in marine and non marine systems our seas are in trouble extinction risk for of well known marine species strengthening school readiness for head start children evaluation of a self regulation intervention self regulation intervention boosts school readiness of at risk children study shows alcohol consumption and risk of heart failure the atherosclerosis risk in communities study drinking moderate amounts of alcohol is linked to reduced risk of heart failure large study finds secondhand smoke and incidence of dental caries in deciduous teeth among children in japan population based retrospective cohort study exposure to secondhand smoke linked to increased risk of tooth decay in young children spatial entanglement patterns and einstein podolsky rosen steering in bose einstein condensates einstein podolsky rosen paradox observed in many particle system for the first time a virus targeted plant receptor like kinase promotes cell to cell spread of rnai viral probe gives ringside view of cell to cell combat early postnatal behavioral cellular and molecular changes in models of huntington disease are reversible by hdac inhibition earlier diagnosis potential therapy for huntington s disease suggested in new research use of plant based therapies and menopausal symptoms a systematic review and meta analysis some plant based therapies associated with modest improvement in menopausal symptoms a supplemented high fat low carbohydrate diet for the treatment of glioblastoma lower carb diet slows growth of aggressive brain tumor in mouse models biological clues to potent dna damaging activities in food and flavoring cancer biologists find dna damaging toxins in common plant based foods multisensory control of multimodal behavior do the legs know what the tongue is doing ? anticipation and navigation do your legs know what your tongue is doing ? increased risk of adverse neurological development for late preterm infants late preterm births present serious risks to newborns syk allelic loss and the role of syk regulated genes in breast cancer survival fifty five genes linked to powerful tumor suppressor predict breast cancer survival systematic analysis of transcription start sites in avian development chick embryos provide valuable genetic data for understanding human development association of local capacity for endoscopy with individual use of colorectal cancer screening and stage at diagnosis hispanics live in areas with limited capacity for colorectal cancer screening study finds domestic airborne black carbon and exhaled nitric oxide in children in nyc air pollution from trucks and low quality heating oil may explain childhood asthma hot spots a multi functional chimeric chaperone serves as a novel immune modulator inducing therapeutic antitumor immunity new cancer vaccine shows future promise in treating and preventing metastatic cancers advanced cell therapies targeting tracking and actuation of cells with magnetic particles much needed update on magnetic tracking in cell therapy secondhand tobacco smoke exposure among hospitalized nonsmokers with coronary heart disease second hand smoke exposure of hospitalized nonsmoker cardiac patients gut dysbiosis impairs recovery after spinal cord injury gut bacteria can aid recovery from spinal cord injury study suggests adverse childhood experiences assessing the impact on health and school engagement and the mitigating role of resilience nearly half of u.s. kids exposed to traumatic social or family experiences during childhood glyoxalase increases anxiety by reducing gabaa receptor agonist methylglyoxal mystery gene reveals new mechanism for anxiety disorders where does bluetongue virus sleep in the winter ? how does bluetongue virus survive through the winter ? age specific probability of live birth with oocyte cryopreservation an individual patient data meta analysis researchers shed new light on egg freezing success rates haemocytes control stem cell activity in the drosophila intestine complex signaling between blood stem cells controls regeneration in fly gut cultivation independent analysis of microbial communities on austrian raw milk hard cheese rinds life on cheese scientists explore the cheese rind microbiome introduction to vertebrate and climatic evolution in the triassic rift basins of tanzania and zambia decade of fossil collecting gives new perspective on triassic period emergence of dinosaurs foreign body ingestions of young children treated in us emergency departments increase in foreign body ingestions among young children benign and deleterious cystic fibrosis transmembrane conductance regulator mutations identified by sequencing in positive cystic fibrosis newborn screen children from california study sheds light on uncategorized genetic mutations in cystic fibrosis opposite risk patterns for autism and schizophrenia are associated with normal variation in birth size phenotypic support for hypothesized diametric gene dosage effects size at birth affects risk of adolescent mental health disorders socioecological transitions trigger fire regime shifts and modulate fire climate interactions in the sierra nevada usa ce human actions influence fire regimes in the sierra nevadas association between asthma and risk of developing obstructive sleep apnea asthma associated with increased risk of obstructive sleep apnea head impact burden and change in neurocognitive function during a season of youth football cumulative sub concussive impacts in a single season of youth football sirt protects in vitro fertilized mouse preimplantation embryos against oxidative stress induced p mediated developmental arrest sirt helps protect preimplantation mouse embryos against stress conditions during in vitro fertilization innate sensing of microbial products promotes wound induced skin cancer bacteria could contribute to development of wound induced skin cancer physical activity and risk of breast cancer colon cancer diabetes ischemic heart disease and ischemic stroke events systematic review and dose response meta analysis for the global burden of disease study higher weekly activity levels linked to lower risk of five chronic diseases transcriptome profiling of peripheral blood in q. deletion syndrome reveals functional pathways related to psychosis and autism spectrum disorder predicting whether children with digeorge syndrome will develop autism or psychosis dehydration melting at the top of the lower mantle new evidence for oceans of water deep in earth water bound in mantle rock alters view of earth s composition control of recollection by slow gamma dominating mid frequency gamma in hippocampus ca finding unravels nature of cognitive inflexibility in fragile x syndrome clomiphene citrate at the dawning of assisted reproduction years ago clomid gave birth to the era of assisted reproduction safety of measles containing vaccines in year old children year study confirms overall safety of measles vaccines preliminary evidence of the short allele of the serotonin transporter gene predicting poor response to cognitive behavior therapy in posttraumatic stress disorder post traumatic stress disorder serotonin system influences vulnerability and treatment nutritional capability of and substrate suitability for pseudogymnoascus destructans the causal agent of bat white nose syndrome fungus that causes white nose syndrome in bats proves hardy survivor indirect consequences of fishing reduction of coralline algae suppresses juvenile coral abundance coral reef study traces indirect effects of overfishing climate driven shifts in sediment chemistry enhance methane production in northern lakes greenhouse gas feedback loop discovered in freshwater lakes outcomes of non invasive ventilation for acute exacerbations of copd in the united states nippv linked to increased hospital mortality rates in small group of patients legal barriers to effective ecosystem management exploring linkages between liability regulations and prescribed fire increased legal liabilities limit prescribed fire use for brush control warming effects on greenhouse gas fluxes in peatlands are modulated by vegetation composition plant community plays key role in controlling greenhouse gas emissions from carbon rich moorlands adjoint based aerodynamic optimization of supersonic biplane airfoils biplane to break the sound barrier cheaper quieter and fuel efficient biplanes could put supersonic travel on the horizon tough on drugs law and order dominance and the neglect of public health in u.s. drug policy us needs harm reduction approach to drug use researcher says supraphysiologic control over hiv replication mediated by cd t cells expressing a re engineered cd based chimeric antigen receptor reengineered immune system cells show early promise against hiv photochemical oxidation of oil reduced the effectiveness of aerial dispersants applied in response to the deepwater horizon spill sunlight reduces effectiveness of dispersants used in oil spills a survey of the fda s aers database regarding muscle and tendon adverse events linked to the statin drug class potency of statins linked to muscle side effects functional tcr t cell screening using single cell droplet microfluidics new immunotherapy technique can specifically target tumor cells evaluation of nurse accuracy in rating procedural pain among pediatric burn patients using the face legs activity cry consolability flacc scale painful reality care providers tend to underestimate pain during pediatric burn dressing changes prescription medicines and the risk of road traffic crashes a french registry based study prescribed medicines are responsible for over percent of road traffic crashes in france study finds prevalence and predictors of antioxidant supplement use during breast cancer treatment the long island breast cancer study project many breast cancer patients take high doses of antioxidants despite possible consequences age dependent sex disproportion in us asthma hospitalization rates menopausal women at greater risk for asthma hospitalization aboveground live carbon stock changes of california wildland ecosystems wildfires emit more greenhouse gases than assumed in california climate targets prefrontal cortex reactivity underlies trait vulnerability to chronic social defeat stress new brain based marker of stress susceptibility finding might help prevent mental illnesses linked with stress future loss of arctic sea ice cover could drive a substantial decrease in california s rainfall future arctic sea ice loss could dry out california predicting migraine responsiveness to botulinum toxin type a injections botulinum toxin injection may help prevent some types of migraine pain comprehensive hearing aid intervention at a free subspecialty clinic program developed to provide free hearing aids to low income adults associations of dietary cholesterol or egg consumption with incident cardiovascular disease and mortality higher egg and cholesterol consumption hikes heart disease and early death risk antiretroviral therapy for the prevention of hiv transmission hiv treatment keeps uninfected partner from contracting the virus how replicable are links between personality traits and consequential life outcomes ? the life outcomes of personality replication project most links between personality traits and life outcomes are replicable increased risk of breast cancer associated with long term shift work in canada long term night shifts linked to doubling of breast cancer risk deregulation of tdp in amyotrophic lateral sclerosis triggers nuclear factor b mediated pathogenic pathways potential new drug target in lou gehrig s disease peritraumatic neural processing and intrusive memories the role of lifetime adversity neural processing with trauma and adversity interact to increase core symptom of ptsd marine species distribution shifts on the u.s. northeast continental shelf under continued ocean warming marine species distribution shifts will continue under ocean warming variation in family experience of pediatric inpatient care as measured by child hcahps largest survey to date of patient and family experience at us children s hospitals falling threshold for treatment of borderline elevated thyrotropin levels balancing benefits and risks widespread prescribing of levothyroxine for borderline thyroid hormone levels the role of viral introductions in sustaining community based hiv epidemics in rural uganda evidence from spatial clustering phylogenetics and egocentric transmission models how sexual contacts with outsiders contribute to hiv infections within communities do us medical licensing applications treat mental and physical illness equivalently ? state medical licensing boards practices may hurt physician mental health extreme hydrodynamic losses of earth like atmospheres in the habitable zones of very active stars rapid destruction of earth like atmospheres by young stars rapid increases in nitrogen oxides are associated with acute myocardial infarction a case crossover study rapid pollution increases may be as harmful to the heart as absolute levels american college of rheumatology american association of hip and knee surgeons guideline for the perioperative management of antirheumatic medication in patients with rheumatic diseases undergoing elective total hip or total knee arthroplasty new medication guidelines for rheumatic disease patients having joint replacement excess phosphoinositide kinase subunit synthesis and activity as a novel therapeutic target in fragile x syndrome scientists identify new drug strategy against fragile x syndrome decreases in maximal oxygen uptake following long duration spaceflight role of convective and diffusive o transport mechanisms astronauts experience decrease in blood vessel function during spaceflight a real time pcr assay for rapid detection and quantification of exserohilum rostratum a causative pathogen of fungal meningitis from injection of contaminated methylprednisolone a rapid test for fungus that caused injection deaths fatalistic beliefs and completion of the hpv vaccination series among a sample of young appalachian kentucky women fatalistic beliefs may prevent appalachian women from completing hpv vaccination series friends or foes infants use shared evaluations to infer others social relationships. infants show ability to tell friends from foes a dual center randomized controlled double blind trial assessing the effect of acupuncture in reducing musculoskeletal symptoms in breast cancer patients taking aromatase inhibitors acupuncture real or sham eases hot flashes due to breast cancer chemo secondhand smoke in cars assessing children s potential exposure during typical journey conditions smoking in cars produces harmful pollutants at levels above who indoor air quality standards late pleistocene california droughts during deglaciation and arctic warming cave study links climate change to california droughts first births with a simplified culture system for clinical ivf and embryo transfer first live births with a novel simplified ivf procedure a candidate gene approach identifies the chrna a b region as a risk factor for age dependent nicotine addiction genetic variations put youth at higher risk for lifetime of tobacco addiction lineage specific evolutionary rate in plants contributions of a screening forcereus cactaceae predictability of dna markers for population level study based on species level variation quitting by gradual smoking reduction using nicotine gum a randomized controlled trial nicotine gum effective for gradual smoking reduction and cessation cross continental increase in methane ebullition under climate change worldwide increase in methane bubbles due to climate change maternal depression mediates the association between intimate partner violence and food insecurity depression key link between intimate partner violence food insecurity ethical legal social and financial implications of neonatal screening for sickle cell anaemia in sub sahara africa in the age of genomic science educating on sickle cell risk in sub saharan africa amd augments the efficacy of mesothelin targeted immune activating vic in mesothelioma by modulating intratumoral immunosuppression combination immunotherapy improves survival in mouse models of mesothelioma effect of attention training on attention bias variability and ptsd symptoms randomized controlled trials in israeli and u.s. combat veterans attention control video game curbs combat vets ptsd symptoms probability of an obese person attaining normal body weight cohort study using electronic health records low chance of obese people recovering normal body weight dmrt protects male gonadal cells from retinoid dependent sexual transdifferentiation male female sex cell determination requires lifelong maintenance protection biomechanical assessment of myocardial infarction using optical coherence elastography biomechanical mapping method aids development of therapies for damaged heart tissue illicit substance use in us adults with chronic low back pain chronic low back pain linked to higher rates of illicit drug use factors associated with epinephrine administration for anaphylaxis in children before arrival to the emergency department half of kids who needed epinephrine didn t get it before trip to the emergency room derivation and internal validation of the ebola prediction score for risk stratification of patients with suspected ebola virus disease ebola virus diagnostic tool developed by physician who worked in liberia school based mental health intervention for children affected by political violence in indonesia a cluster randomized trial mental health intervention at school reduces ptsd among indonesian children affected by violence dispersal of mycobacterium tuberculosis via the canadian fur trade tuberculosis strain spread by the fur trade reveals stealthy approach of epidemics association between environmental tobacco smoke exposure and dementia syndromes passive smoking increases risk of severe dementia according to study in china higher pbde serum concentrations may be associated with feline hyperthyroidism in swedish cats flame retardants could contribute to hyperthyroidism in older cats d microfluidic liver cultures as a physiological preclinical tool for hepatitis b virus infection organ on chip technology enters next stage as experts test hepatitis b virus use of nonaspirin nonsteroidal anti inflammatory drugs during pregnancy and the risk of spontaneous abortion anti inflammatory drugs taken in early pregnancy more than double risk of miscarriage study finds p coordinates decidual sestrin ampk mtorc signaling to govern parturition timing common diabetes drug may help prevent preterm birth induction of smell through transethmoid electrical stimulation of the olfactory bulb electrical stimulation in the nose induces sense of smell in human subjects terminal decline in well being the role of social orientation active social life associated with well being in life investigations of enantiopure nicotine haptens using an adjuvanting carrier in anti nicotine vaccine development nicotine vaccine delays the drug s effects in mice pneumonia and influenza hospitalizations in elderly people with dementia older patients with dementia at increased risk for flu mortality past and future global transformation of terrestrial ecosystems under climate change most land based ecosystems worldwide risk major transformation due to climate change genetics of blood lipids among multi ethnic participants of the million veteran program genetics of cholesterol point to possible drug targets for heart disease diabetes escaping underground nets extracellular dnases degrade plant extracellular traps and contribute to virulence of the plant pathogenic bacterium ralstonia solanacearum arms race at the plant root how soil bacteria fight to escape sticky root traps imaging of blast injuries to the lower extremities sustained in the boston marathon bombing marathon bombing victims aided by rapid response imaging of injuries ancient genomic changes associated with domestication of the horse scythian horse breeding unveiled lessons for animal domestication global warming benefits the small in aquatic ecosystems climate change influences the size of marine organisms big advantage for the small nutritional factors and gender influence age related dna methylation in the human rectal mucosa new evidence for epigenetic effects of diet on healthy aging stall in canonical autophagy lysosome pathways prompts nucleophagy based nuclear breakdown in neurodegeneration new mechanisms found of cell death in neurodegenerative disorders declining patterns of pacific northwest steelhead trout oncorhynchus mykiss adult abundance and smolt survival in the ocean steelhead trout population declines linked with poor survival of young fish in the ocean variation in cancer risk among tissues can be explained by the number of stem cell divisions bad luck of random mutations plays predominant role in cancer study shows pesticide methoxychlor promotes the epigenetic transgenerational inheritance of adult onset disease through the female germline pesticide linked to three generations of disease methoxychlor causes epigenetic changes topological lc circuits based on microstrips and observation of electromagnetic modes with orbital angular momentum discovery of topological lc circuits transporting em waves without backscattering peptide coated platinum nanoparticles with selective toxicity against liver cancer cells platinum nanoparticles for selective treatment of liver cancer cells depressive symptomatology in severe dementia in a european sample prevalence associated factors and prescription rate of antidepressants depression in dementia more common in community care study finds filovirus receptor npc contributes to species specific patterns of ebolavirus susceptibility in bats arms race between ebola virus and bats waged for millions of years targeted advertising promotion and price for menthol cigarettes in california high school neighborhoods menthol cigarettes marketed in predatory pattern study shows decreased becn mrna expression in human breast cancer is associated with estrogen receptor negative subtypes and poor prognosis study links deficiency of cellular housekeeping gene with aggressive forms of breast cancer signaling from maize organ primordia via fasciated ear regulates stem cell proliferation and yield traits new stem cell pathway indicates route to much higher yields in maize staple crops clinical benefits of a multivariable prediction model for bladder cancer a decision analytic approach statistical model superior to traditional criteria in bladder treatment decision extended duration dual antiplatelet therapy and mortality a systematic review and meta analysis blood clot heart attack risk after coronary stent treatment reduced with continuation of dual antiplatelet therapy beyond one year barriers to drug use behavior change among primary care patients in urban united states community health centers routine drug screening should be part of primary care settings study recommends do girls profit more ? gender specific effectiveness of a life skills program against alcohol consumption in early adolescence how children learn to say no gender specific effectiveness of a life skills program against alcohol consumption in early adolescence the mevalonate pathway regulates primitive streak formation via protein farnesylation metabolic pathway regulating key stage of embryo development revealed atypical pkc iota controls stem cell expansion via regulation of the notch pathway a prkci gene keeps stem cells in check offspring of parents who were separated and not speaking to one another have reduced resistance to the common cold as adults children of separated parents not on speaking terms more likely to develop colds as adults the spread of hiv in pakistan bridging of the epidemic between populations study of hiv increase in pakistan could benefit other research face to face versus online behavioral parent training for young children at risk for adhd treatment engagement and outcomes online parent training helps young kids with adhd chaotic magnetic field lines and spontaneous development of current sheets chaotic magnetic field lines may answer the coronal heating problem developmental brain dysfunction revival and expansion of old concepts based on new genetic evidence new genetic evidence suggests a continuum among neurodevelopmental and psychiatric disorders extreme vulnerability of idh mutant cancers to nad depletion potential treatment target for idh mutant cancers identified membrane stabilization by modified steroid offers a potential therapy for muscular dystrophy due to dysferlin deficit stabilizing dysferlin deficient muscle cell membrane improves muscle function searching for exotic particles in high energy physics with deep learning deep learning makes search for exotic particles easier new computing techniques could aid hunt for higgs bosons a federated ecosystem for sharing genomic clinical data new vision model for genomic and clinical data sharing effect of roux en y gastric bypass surgery on the sex steroids and quality of life in obese men obesity linked to hormone imbalance that impacts sexual quality of life assessing global popularity and threats to important bird and biodiversity areas using social media data social media data reveal benefits or threats to biodiversity by visitors to nature locations effectiveness of resistance training or jumping exercise to increase bone mineral density in men with low bone mass a month randomized clinical trial exercise may reverse age related bone loss in middle aged men body mass index and injury risk among u.s. children years old in motor vehicle crashes overweight children at increased risk of arm and leg injuries following motor vehicle crash geographical differences in subjective well being predict extraordinary altruism altruistic acts more common in states with high well being r and s isomers of cotinine augment cholinergic responses in vitro and in vivo nicotine metabolite amplifies action of the primary chemical messenger for learning memory aldolase b mediated fructose metabolism drives metabolic reprogramming of colon cancer liver metastasis metastatic cancer gorges on fructose in the liver suppression of the cd t cell response by human papillomavirus type e occurs in langerhans cell depleted mice researchers probe hpv s manipulation of immune system antiproliferative activity of tea catechins associated with casein micelles using ht colon cancer cells new role for milk delivering polyphenols with anti cancer activity prevalence of parental concerns about childhood vaccines the experience of primary care physicians results on national study of parental concerns about childhood vaccines announced effects of diurnal variation of gut microbes and high fat feeding on host circadian clock function and metabolism gut microbes affect circadian rhythms and metabolism in mice cerebral cavernous malformation protein ccm inhibits sprouting angiogenesis by activating delta notch signaling defective signaling pathway leads to vascular malformations in the brain the ability of household pitcher style water purifiers to remove microcystins depends on filtration rate and activated carbon source buyer beware some water filter pitchers much better at toxin removal ultra high signal detection of human embryonic stem cells driven by two dimensional materials novel method produces highest ever signals for human embryonic stem cell detection the effectiveness of school based mental health services for elementary aged children a meta analysis teachers and other school based professionals can treat children s mental health problem brain activation in high functioning older adults and falls brain activity may predict risk of falls in older adults economic development and coastal ecosystem change in china study measures steep coastal costs of china s gdp growth human rpe gene therapy for leber congenital amaurosis persistence of early visual improvements and safety at year vision researchers see unexpected gain one year into blindness trial holocene history of lake of the woods ontario manitoba and minnesota post glacial history of lake of the woods the first megatheropod tracks from the lower jurassic upper elliot formation karoo basin lesotho mega carnivore dinosaur roamed southern africa million years ago h k methyltransferases and demethylases control lung tumor propagating cells and lung cancer progression proposed cancer treatment may boost lung cancer stem cells study warns preterm birth risk factor for early onset chronic diseases adults born preterm at risk of early chronic disease the favorable ifnl genotype escapes mrna decay mediated by au rich elements and hepatitis c virus induced micrornas newly found tactics in offense defense struggle with hepatitis c virus relation between epstein barr virus and multiple sclerosis analytic study of scientific production epstein barr virus could be risk factor for multiple sclerosis study suggests impaired adult myelination in the prefrontal cortex of socially isolated mice new form of brain plasticity how social isolation disrupts myelin production adventitial msc like cells are progenitors of vascular smooth muscle cells and drive vascular calcification in chronic kidney disease scientists find culprit responsible for calcified blood vessels in kidney disease an illustrated guide to the identification of the known species of diatraea guilding lepidoptera crambidae crambinae based on genitalia moth genitalia is the key to snout grass borers from the western hemisphere epithelial nf b enhances transmucosal fluid movement by altering tight junction protein composition after t cell activation inflammatory mediator regulates diarrhea in inflammatory bowel disease pregnant women with posttraumatic stress disorder and risk of preterm birth ptsd major depressive episode appears to increase risk of preterm birth in utero undernutrition in male mice programs liver lipid metabolism in the second generation offspring involving altered lxra dna methylation malnutrition during pregnancy may affect the health of future generations live fast die young accelerated growth mortality and turnover in street trees urban trees live fast die young compared to those in rural forests central gain restores auditory processing following near complete cochlear denervation brain s amplifier compensates for lost inner ear function younger age of menopause in women with cerebral aneurysms early menopause linked to increased risk of brain aneurysm pegylated derivatives of recombinant human arginase rharg for sustained in vivo activity in cancer therapy preparation characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell h cc new design of engineered arginine depleting enzymes as multi potent anti cancer agents sources and perceived credibility of vaccine safety information for parents parents trust doctors most when it comes to information about vaccine safety insect outbreak shifts the direction of selection from fast to slow growth rates in the long lived conifer pinus ponderosa slow growing ponderosas survive mountain pine beetle outbreaks autonomous biogeochemical floats detect significant carbon dioxide outgassing in the high latitude southern ocean diving robots find antarctic winter seas exhale surprising amounts of carbon dioxide impact of commuting exposure to traffic related air pollution on cognitive development in children walking to school air pollution exposure on home to school routes reduces the growth of working memory human nonvisual opsin regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin receptor how a member of a family of light sensitive proteins adjusts skin color super natural killer cells that target metastases in the tumor draining lymph nodes engineers develop killer cells to destroy cancer in lymph nodes first evidence of frugivory in myotis chiroptera vespertilionidae myotinae black mouse eared bat goes green first case of a fruit eating bat in the largest genus the human splicing code reveals new insights into the genetic determinants of disease deep learning finds autism cancer mutations in unexplored regions of genome discrepancies between patients and physicians in the perception of rheumatoid arthritis disease activity rheumatoid arthritis discrepancies between patients and physicians in perception of rheumatoid arthritis quantified for first time monitoring southwest greenlands ice sheet melt with ambient seismic noise scientists track greenland s ice melt with seismic waves risk of end stage renal disease in hiv positive potential live kidney donors first ever living donor hiv to hiv kidney transplant effectiveness of virtual reality exposure therapy for active duty soldiers in a military mental health clinic innovative virtual reality exposure therapy shows promise for returning troops are saving appearance responses typical communication patterns in alzheimer s disease ? a typical communication pattern of people with alzheimer s disease impact of centralising acute stroke services in english metropolitan areas on mortality and length of hospital stay difference in differences analysis centralizing stroke services can reduce deaths time in hospital reported severe respiratory disease and deaths concurrent with atypical a h n influenza circulation of swine origin in mexico first wave of swine flu hit young people harder than expected annual high dose oral vitamin d and falls and fractures in older women a randomized controlled trial high dose vitamin d linked with increased risk of falls fractures among older women formation of diamonds in laser compressed hydrocarbons at planetary interior conditions scientists create diamond rain that forms in the interior of icy giant planets kinetic characterization of the critical step in hiv protease maturation crucial step in aids virus maturation simulated for first time mother of ft and tfl represses seed germination under far red light by modulating phytohormone responses inarabidopsis thaliana seeing the light scientists unlock seed germination process vitamin c deficiency in early postnatal life impairs spatial memory and reduces the number of hippocampal neurons in guinea pigs vitamin c deficiency impairs early brain development guinea pig study finds the american cancer society challenge goal to reduce us cancer mortality by between and results and reflections american cancer society report assesses progress against goals set for nation human cd d knock in mouse model demonstrates potent antitumor potential of human cd d restricted invariant natural killer t cells scientists design mouse with more human like immune response the human gut microbiome as a screening tool for colorectal cancer gut microbiome analysis improved noninvasive colorectal cancer screening a magnetic compass that might help coral reef fish larvae return to their natal reef magnetic force pulls baby reef fish back home new and poorly known holarctic species of boletina staeger diptera mycetophilidae the tip of an iceburg four new fungus gnat species from the scandinavian north population based trends in high grade cervical lesions in the early human papillomavirus vaccine era in the united states decreased rates of high grade cervical lesions in young women fine tuning of cd t cell mitochondrial metabolism by the respiratory chain repressor mcj dictates protection to influenza virus putting the brakes on cell s engine could give flu other vaccines a boost dna demethylation of inflammasome associated genes is enhanced in patients with cryopyrin associated periodic syndromes an epigenetic mechanism is involved in development of autoinflammatory diseases inequalities in the incidence of cervical cancer in south east england an investigation of population risk factors incidence rates of cervical cancer linked to deprivation a hominin femur with archaic affinities from the late pleistocene of southwest china red deer cave people bone points to mysterious species of pre modern human women s marriage age matters for public health a review of the broader health and social implications in south asia multiple health implications of women s early marriage go beyond early childbearing parenting practices in the context of legal marijuana voices from seattle parents parenting in the age of legal pot household rules conversations help guide teen use a novel qpcr assay for the detection of african animal trypanosomosis in trypanotolerant and trypanosusceptible cattle breeds african breed of cattle harbors potential defense against life threatening parasite a to i rna editing contributes to proteomic diversity in cancer rna editing study shows potential for more effective precision cancer treatment non specific blocking of mir p guide strand in triple negative breast cancer cells by amplifying passenger strand activity rna mystery solved in triple negative breast cancer ghrelin affects stopover decisions and food intake in a long distance migrant departure of migratory birds from stopover sites is hormone controlled the transcription factor sp is reduced in postmortem cerebellum of bipolar disorder subjects control by depolarization and lithium gene regulatory protein is reduced in bipolar disorder cd controls the uptake of l tryptophan through lat cd and ahr dependent secretion of il in psoriasis scientists identify an essential role of the immune receptor cd in psoriasis diagnostic blood loss from phlebotomy and hospital acquired anemia during acute myocardial infarction blood loss from lab testing associated with hospital acquired anemia for patients with heart attacks study finds perimenstrual exacerbation of symptoms in borderline personality disorder evidence from multilevel models and the carolina premenstrual assessment scoring system symptoms worsen around menses for people with borderline personality disorder optic nerve hypoplasia is a pervasive subcortical pathology of visual system in neonates biological mechanism of a leading cause of childhood blindness revealed in new research the first reported ceratopsid dinosaur from eastern north america owl creek formation upper cretaceous mississippi usa rare tooth find reveals horned dinosaurs in eastern north america molecular identity of human outer radial glia during cortical development stem cell research hints at evolution of human brain pollen induced innate recruitment of neutrophils facilitates induction of allergic sensitization and airway inflammation study uncovers mechanism responsible for pollen induced allergies genome wide association study to identify the genetic base of smallholder farmer preferences of durum wheat traits combining genomics with farmers traditional knowledge to improve wheat production strategies for simulating the drift of marine debris lessons learnt from the drift analysis of mh plane crash debris closing the gender gap in competitiveness through priming closing the gender gap in competitiveness with a psychological trick five year outcomes after laparoscopic gastric bypass and laparoscopic duodenal switch in patients with body mass index of to five year outcomes following bariatric surgery in patients with bmis of to antitumor activity of the mek inhibitor tak against melanoma cell lines and patient derived tumor explants promising anti cancer activity in experimental drug next gen melanoma drug tak excels in lab tests skin glands of an aquatic salamander vary in size and distribution and release antimicrobial secretions effective against chytrid fungal pathogens louisiana amphibian shows unique resistance to global disease association of vision loss with cognition in older adults visual impairment among older adults associated with poor cognitive function bicarbonates dissolved in irrigation water contribute to soil co efflux researchers explore an often ignored source of greenhouse gas gene therapy in patient specific stem cell lines and a preclinical model of retinitis pigmentosa with membrane frizzled related protein defects patient specific stem cells and personalized gene therapy pkm released by neutrophils at wound site facilitates early wound healing by promoting angiogenesis enzyme involved in glucose metabolism promotes wound healing study finds lifetime marijuana and alcohol use and cognitive dysfunction in people with human immunodeficiency virus infection marijuana use associated with cognitive dysfunction in people with hiv who have substance abuse disorder study finds the flashlight fish anomalops katoptron uses bioluminescent light to detect prey in the dark splitfin flashlight fish uses bioluminescent light to illuminate plankton adiposity chronic inflammation and the prepubertal decline of sex hormone binding globulin in children evidence for associations with the timing of puberty earlybird new link between obesity in young lowering of age of puberty differential responses of prochlorococcus and sar dominated bacterioplankton groups to atmospheric dust inputs in the tropical northeast atlantic ocean bacterioplankton responses to desert dust in the sub tropical northeast atlantic acoustic monitoring of atlantic cod gadus morhua in massachusetts bay implications for management and conservation acoustic monitoring of atlantic cod reveals clues to spawning behavior increased caffeine intake is associated with reduced risk of basal cell carcinoma of the skin drinking coffee may reduce risk of most common form of skin cancer effects of ocean acidification on the potency of macroalgal allelopathy to a common coral great barrier reef building coral under threat from poisonous seaweed effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models tumor micro environment is a rough neighborhood for nanoparticle cancer drugs trends in the incidence of and charges associated with firearm related injuries among pediatric patients gunshot wounds in children account for million in emergency room and inpatient charges annually infrared thermography as a support tool for screening and early diagnosis in emergencies infrared thermography a support tool for orthopedic diagnosis chronic periodontal disease periodontal pathogen colonization and increased risk of precancerous gastric lesions increased oral pathogens decreased bacterial diversity predict precancerous stomach cancer lesions annealing effects on hydrogenated diamond nor logic circuits diamond based circuits can take the heat for advanced applications exposure to glyphosate based herbicides and risk for non hodgkin lymphoma a meta analysis and supporting evidence exposure to chemical in roundup increases risk for cancer study finds global pattern of nest predation is disrupted by climate change in shorebirds decline in shorebirds linked to climate change experts warn illness beliefs and the sociocultural context of diabetes self management in british south asians a mixed methods study cultural health beliefs and social networks crucial in south asian people s management of diabetes associations of socioeconomic variables with resection stage and survival in patients with early stage pancreatic cancer socioeconomic factors associated with undergoing surgery for early stage pancreatic cancer the empty vessel physician physicians instrumentality makes them seem personally empty patients with immediate medical needs tend to perceive doctors as emotionless study finds the impact of whole genome sequencing on the primary care and outcomes of healthy adult patients sequencing finds rare genetic disease risk in one out of five healthy adults formation of most of our coal brought earth close to global glaciation formation of coal almost turned our planet into a snowball risks of ocean acidification in the california current food web and fisheries ecosystem model projections ocean acidification to hit west coast dungeness crab fishery new assessment shows a framework for evaluating the public health impact of e cigarettes and other vaporized nicotine products top tobacco control experts to fda studies of e cigs suggest more benefit than harm notch signal strength controls cell fate in the haemogenic endothelium step forward in obtaining blood stem cells in laboratory a coupled human earth model perspective on long term trends in the global marine fishery unrestricted improvements in fishing technology threaten the future of seafood citrullinated peptide dendritic cell immunotherapy in hla risk genotype positive rheumatoid arthritis patients early clinical trial success for new rheumatoid arthritis treatment cytochrome p monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization key compounds to resolve abnormal vascular growth in age related macular degeneration identified physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained sustained aerobic exercise increases adult neurogenesis in brain cardiovascular disease and cognitive decline in postmenopausal women results from the women s health initiative memory study heart disease linked with dementia in older postmenopausal women vitamin d metabolism related genetic variants dietary protein intake and improvement of insulin resistance in a year weight loss trial pounds lost people with genetic variant increasing vitamin d metabolism improve blood sugar control with high protein weight loss diet on the generation of solar spicules and alfv nic waves solar research on the generation of solar spicules and alfvenic waves log normal turbulence dissipation in global ocean models new understanding of ocean turbulence could improve climate models laparoscopic hysterectomy with morcellation versus abdominal hysterectomy for presumed fibroids in premenopausal women a decision analysis laparoscopic hysterectomy with morcellation may be safer than abdominal procedure new study indicates super catastrophic disruption of asteroids at small perihelion distances puzzling asteroid observations explained by destruction of asteroids close to sun multiscale modeling of membrane rearrangement drainage and rupture in evolving foams heady mathematics describing popping bubbles in a foam mri investigation of the sensorimotor cortex and the corticospinal tract after acute spinal cord injury a prospective longitudinal study irreversible tissue loss seen within days of spinal cord injury necrotizing enterocolitis in neonates undergoing the hybrid approach to complex congenital heart disease light shed on deadly gi disease in infants born with complex congenital heart disease effect of periodontal therapy on arterial structure and function among aboriginal australians a randomized controlled trial treating gum disease improves vascular health in indigenous australians study virulence genes are a signature of the microbiome in the colorectal tumor microenvironment new colon cancer culprit found in gut microbiome shifts in microbial community structure and function in surface waters impacted by unconventional oil and gas wastewater revealed by metagenomics oil and gas wastewater spills alter microbes in west virginia waters estrogen receptor induces antiinflammatory and antitumorigenic networks in colon cancer cells researchers explore treatments for breast and colon cancers experimental infection of snakes with ophidiomyces ophiodiicola causes pathological changes that typify snake fungal disease fungus causes emerging snake disease found in eastern us reduction in venous thromboembolism events trauma performance improvement and loop closure through participation in a state wide quality collaborative statewide quality improvement program helps lower rates of trauma complications magnetic alignment in carps evidence from the czech christmas fish market first evidence of fish sensing geomagnetic fields from a czech christmas market a new therocephalian gorynychus masyutinae gen. et sp. nov. from the permian kotelnich locality kirov region russia monstrous new russian saber tooth fossils clarify early evolution of mammal lineage univariate and multivariate analysis of risk factors for severe clostridium difficile associated diarrhoea importance of co morbidity and serum c reactive protein what is the risk factor for severe clostridium difficile associated diarrhea ? comparative pathogenicity of united kingdom isolates of the emerging pathogencandida aurisand other key pathogeniccandidaspecies fungus causing fatal infections in hospitalized patients has unique growth patterns a simplified urban extent algorithm to characterize surface urban heat islands on a global scale and examine vegetation control on their spatiotemporal variability new algorithm provides a more detailed look at urban heat islands simultaneous brain cervical cord fmri reveals intrinsic spinal cord plasticity during motor sequence learning innovative imaging study shows that the spinal cord learns on its own aerobic anoxygenic phototrophs in gold mine tailings in nopiming provincial park manitoba canada new metalloid oxide reducing bacteria found in manitoba s nopiming gold mine tailings rap music use perceived peer behavior and sexual initiation among ethnic minority youth rap music adolescent sexual initiation mediated by perceived peer behavior say researchers the adult repetitive behaviours questionnaire rbq a a self report measure of restricted and repetitive behaviours psychologists develop first adult self assessment for repetitive behaviours in autism mechanisms in endocrinology mechanisms and evaluation of bone fragility in type diabetes mellitus experts urge early evaluation of fracture risk in diabetics activity dependent neuroprotective protein adnp exhibits striking sexual dichotomy impacting on autistic and alzheimer s pathologies protective brain protein reveals gender implications for autism alzheimer s research two new species of euptychia h bner from the upper amazon basin lepidoptera nymphalidae satyrinae rare amazonian butterfly named after british national treasure sir david attenborough maternal body condition influences magnitude of anti predator response in offspring in stickleback fish dads influence offspring behavior and gene expression numerical comparison of dispersion of human exhaled droplets under different ventilation methods a layer of cool healthy air stratum ventilation systems may reduce spread of airborne diseases mortality risk and social network position in resident killer whales sex differences and the importance of resource abundance weak social ties a killer for male whales two fossil species of metrosideros myrtaceae from the oligo miocene golden fleece locality in tasmania australia australian origin likely for iconic new zealand tree regulation of adiponectin secretion by adipocytes in the polycystic ovary syndrome role of tumor necrosis factor fat behaves differently in patients with polycistic ovary syndrome global cortical thinning in acute anorexia nervosa normalizes following long term weight restoration brain research reveals new hope for patients with anorexia nervosa a new vesicle trafficking regulator ctl plays a crucial role in ion homeostasis a new regulator of vesicle trafficking in plants prospective approach to breast cancer risk prediction in african american women the black women s health study model new model better predicts breast cancer risk in african american women microrna provides neuroprotection for tauopathies via multiple signaling pathways newly characterized molecule offers possibilities for novel alzheimer s treatments anthranilic diamide insecticides delivered via multiple approaches to control vegetable pests a case study in snap bean anthranilic diamides could potentially replace neonicotinoid seed treatments and pyrethroid sprays angular power spectrum of the diffuse gamma ray emission as measured by the fermi large area telescope and constraints on its dark matter interpretation no trace of dark matter in gamma ray background energy drinks alcohol sports and traumatic brain injuries among adolescents energy drinks linked to traumatic brain injury in teens clearance of senescent glial cells prevents tau dependent pathology and cognitive decline zombie cells found in brains of mice prior to cognitive loss enhancing the contrast sensitivity function through action video game training action video games improve vision new research shows a new computer based pediatric vision screening test researchers develop new computer based vision screening test for young children effects of the australian national hand hygiene initiative after years on infection control practices health care worker education and clinical outcomes a longitudinal study national handwashing campaign reduces incidence of staphylococcus aureus infection in australia s hospitals a quantitative analysis linking seabird mortality and marine debris ingestion balloons the number marine debris risk of mortality for seabirds ctip expression in human head and neck squamous cell carcinoma is linked to poorly differentiated tumor status new diagnostic advance seen for head throat cancer associations of maternal prepregnancy body mass index and gestational weight gain with adult offspring cardiometabolic risk factors the jerusalem perinatal family follow up study excess weight in pregnant women can have negative health implications for offspring in adulthood differences in attitude education and knowledge about oral anticoagulation therapy among patients with atrial fibrillation in europe result of a self assessment patient survey conducted by the european heart rhythm association patients with no schooling benefit least from blood thinning medications active psf shaping and adaptive optics enable volumetric localization microscopy through brain sections new development in d super resolution imaging gives insight on alzheimer s disease adaptations to hydrothermal vent life in kiwa tyleri a new species of yeti crab from the east scotia ridge antarctica first species of yeti crab from hydrothermal vent systems near antarctica described long term study of dune infiltration systems to treat coastal stormwater runoff for fecal bacteria researchers devise hidden dune filters to treat coastal stormwater runoff a dna based molecular motor that can navigate a network of tracks dna motor programmed to navigate a network of tracks comprehensive cell surface protein profiling identifies specific markers of human naive and primed pluripotent states new tools to study the origin of embryonic stem cells an association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders mouse genes guide search for human anxiety disorder genes increased caffeine consumption is associated with reduced hepatic fibrosis caffeine consumption associated with less severe liver fibrosis viral gene transfer of apps rescues synaptic failure in an alzheimer s disease mouse model protein repairs nerve cell damage novel gene therapy approach to treat alzheimer s disagreement between symptom reflux association analysis parameters in pediatric gastroesophageal reflux disease investigation disagreement on symptom reflux association analysis parameters in infants genetic rescue increases fitness and aids rapid recovery of an endangered marsupial population genetic rescue boosts recovery of australia s endangered mountain pygmy possums quantifying coal power plant responses to tighter so emissions standards in china reduction in sulfur emissions from power plants in china molecular targets for diabetes mellitus associated erectile dysfunction identifying molecular targets for diabetes related erectile dysfunction structural and functional insights into izumo recognition by juno in mammalian fertilization new findings and research methods leading to elucidation of fertilization mechanism structural mechanism of functional modulation by gene splicing in nmda receptors structural variation in key brain receptor enables it to cope with hostile condition mechanically stimulated atp release from murine bone cells is regulated by a balance of injury and repair bone cell response to mechanical force is balance of injury and repair mafb c maf deficiency enables self renewal of differentiated functional macrophages adult cell self renewal without stem cells ? month old children with larger oral vocabularies display greater academic and behavioral functioning at kindergarten entry two year olds with larger oral vocabularies enter kindergarten better prepared climate fails to predict wood decomposition at regional scales climate change termites fungi play more important role in decomposition than temperature effect of vitamin d and calcium supplementation on cancer incidence in older women vitamin d calcium supplementation among older women does not significantly reduce risk of cancer study finds hepatic acyl coa diacylglcyerol acyltransferase dgat overexpression diacylglycerol and insulin sensitivity loss of key estrogen regulator may lead to metabolic syndrome and atherosclerosis vaccine effectiveness against laboratory confirmed influenza hospitalizations among young children during the to influenza seasons in ontario canada flu vaccine prevents hospitalization in children study shows dental consultations in uk general practice and antibiotic prescribing rates a retrospective cohort study concern over gps prescribing unnecessary antibiotics for toothache adolescents text message communication and growth in antisocial behavior across the first year of high school antisocial texting by teens linked to bad behavior what can seabirds tell us about the tide ? what seabirds can tell us about the tide spectroscopy and thermal modelling of the first interstellar object i u oumuamua alien object oumuama was a natural body visiting from another solar system the reduction of genetic diversity in threatened vertebrates and new recommendations regarding iucn conservation rankings endangered animals can be identified by rate of genetic diversity loss in vitro characterization of an electroactive carbon nanotube based nanofiber scaffold for tissue engineering nanomaterials in a heart beat nanomaterial may allow regeneration of cardiac cells gender inequity associated with increased child physical abuse and neglect a cross country analysis of population based surveys and country level statistics child abuse and neglect linked to gender inequality the endogenous tryptophan metabolite and nad precursor quinolinic acid confers resistance of gliomas to oxidative stress brain cancer a circuitous route to therapy resistance healthier children s meals in restaurants an exploratory study to inform approaches that are acceptable across stakeholders attitudes vary across groups regarding meal choice in restaurants cyanate and urea are substrates for nitrification by thaumarchaeota in the marine environment key players in the marine nitrogen cycle can utilize cyanate and urea novel loci associated with attention deficit hyperactivity disorder are revealed by leveraging polygenic overlap with educational attainment novel genetic variants for adhd linked to educational attainment mechanics of diseased red blood cells in human spleen and consequences for hereditary blood disorders how sickled red blood cells stick to blood vessels ldl cholesterol lowering for the primary prevention of cardiovascular disease among men with primary elevations of ldl cholesterol levels of mg dl or above analyses from the woscops year randomised trial and year observational follow up statins reduce deaths from coronary heart disease by per cent in men according to longest ever study analysis of t cell responses to chimpanzee adenovirus vectors encoding hiv gag pol nef antigen breakthrough in the treatment of hiv by successfully developing a prototype vaccine vector socioeconomic status and disability progression in multiple sclerosis disability progression in multiple sclerosis linked to income education a community choir intervention to promote well being among diverse older adults results from the community of voices trial community choirs reduce loneliness and increase interest in life for older adults chromosomal instability induces cellular invasion in epithelial tissues a study using drosophila sheds light on the metastatic behavior of human tumors from healthcare to warfare and reverse how should we regulate dual use neurotechnology ? from healthcare to warfare how to regulate brain technology deglacial rapid sea level rises caused by ice sheet saddle collapses trigger for past rapid sea level rise discovered a soxb gene acts as an anterior gap gene and regulates posterior segment addition in a spider a common ancestral gene causes body segmentation in spiders and insects one factor or two parallel processes ? comorbidity and development of adolescent anxiety and depressive disorder symptoms depression and anxiety disorders of adolescents are not the same thing systems vaccinology identifies an early innate immune signature as a correlate of antibody responses to the ebola vaccine rvsv zebov ebola early immune response provides insight into vaccination utilization patterns of conventional and complementary alternative treatments in children with autism spectrum disorders and developmental disabilities in a population based study complementary medicine widely used to treat children with autism developmental delay genome wide meta analysis identifies bone mineral density loci and reveals loci associated with risk of fracture new genetic regions linked to bone weakening disease and fractures sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response sickle cells show potential to attack aggressive cancer tumors poor unsafe and overweight the role of feeling unsafe at school in mediating the association among poverty exposure youth screen time physical activity and weight status lack of safety at school poverty linked to childhood obesity suppression of gata nuclear import and phosphorylation a novel mechanism of corticosteroid action in allergic disease novel mechanism of action of corticosteroids in allergic diseases genome editing with cas in adult mice corrects a disease mutation and phenotype erasing a genetic mutation researchers reverse a liver disorder in mice by correcting a mutated gene nanoscale bacteria enabled autonomous drug delivery system nanobeads enhances intratumoral transport of nanomedicine bacteria based drug delivery system that outperforms conventional methods an examination of the effects of concealed weapons laws and assault weapons bans on state level murder rates restrictive concealed weapons laws can lead to an increase in gun related murders plasma antibody profiles as diagnostic biomarkers for tuberculosis new strategy tests for dangerous stage of tuberculosis in asia generation of pulmonary neuroendocrine cells and sclc like tumors from human embryonic stem cells researchers develop human cell based model to study small cell lung cancer promoting influenza vaccination insights from a qualitative meta analysis of years of influenza related communications research by u.s. centers for disease control and prevention cdc personal experience a major driver in decision for or against flu vaccination large wind ripples on mars a record of atmospheric evolution a bewildering form of sand dune discovered on mars evidence that ship noise increases stress in right whales lull in ship noise after sept. attacks eased stress on right whales visual field change and hour iop related profile with a contact lens sensor in treated glaucoma patients smart contact lens helps predict disease progression in glaucoma patients high response rate to pd blockade in desmoplastic melanomas immunotherapy highly effective in treatment of rare skin cancer brain tissue volume changes following weight gain in adults with anorexia nervosa brain volume found to change following weight gain in adults with anorexia development and evaluation of a real time pcr multiplex assay for the detection of allergenic peanut using chloroplast dna markers dna based method detects trace amounts of peanut in foods urban heat islands in china enhanced by haze pollution study reveals surprising role of haze in the warming of chinese cities prevalence of active convulsive epilepsy in sub saharan africa and associated risk factors cross sectional and case control studies parasites and poor antenatal care are main causes of epilepsy in africa rising pco in freshwater ecosystems has the potential to negatively affect predator induced defenses in daphnia rising co is causing trouble in freshwaters too study suggests smoking body weight physical exercise and risk of lower limb total joint replacement in a population based cohort of men male smokers less likely to need joint replacement surgery of hip or knee cognitive behavioral therapy for treatment of pediatric chronic migraine adding cognitive behavioral therapy to treatment of pediatric migraine helps relieve symptoms depression and all cause mortality risk in hiv infected and hiv uninfected us veterans a cohort study hiv infection increases the risk of death associated with depressive symptoms cognitive behavioral therapy in primary care for youth declining antidepressants a randomized trial counseling in primary care clinics helps speed recovery for depressed teens the dual functions of rip in fas induced hepatocyte death during sepsis the death switch in sepsis also promotes survival friends with benefits on the positive consequences of pet ownership the truth about cats and dogs pets are good for mental health of everyday people association between maternal intimate partner violence and incident obesity in preschool aged children results from the fragile families and child well being study intimate partner violence against mothers associated with children s obesity hematopoietic stem cell gene therapy with a lentiviral vector in x linked adrenoleukodystrophy gene therapy technique slows brain disease ald featured in movie lorenzo s oil west african monsoon dynamics inferred from abrupt fluctuations of lake mega chad largest freshwater lake on earth was reduced to desert dunes in just a few hundred years global dietary calcium intake among adults a systematic review global calcium consumption appears low especially in asia unusual proton transfer kinetics in water at the temperature of maximum density the behavior of water scientists find new properties of h o temporal trends of dialysis requiring acute kidney injury after orthotopic cardiac and liver transplant hospitalizations impact of kidney injury on non renal solid organ transplants antarctica the final frontier for marine biological invasions antarctica the final frontier for marine biological invasions ? a framework to rank genomic alterations as targets for cancer precision medicine the esmo scale for clinical actionability of molecular targets escat new esmo tumor dna scale helps match patients with cancer to optimal targeted medicines short term associations between ambient air pollutants and pediatric asthma emergency department visits ozone and traffic pollution increase asthma related hospitalizations in children association of epidemiologic factors and genetic variants influencing hypothalamic pituitary adrenocortical axis function with postconcussive symptoms after minor motor vehicle collision gene variants involved in stress responses affect post concussive symptoms defining human embryo phenotypes by cohort specific prognostic factors in vitro fertilization new method predicts which women will get pregnant impact of traditional greek dancing on jumping ability muscular strength and lower limb endurance in cardiac rehabilitation programmes greek dancing improves jumping ability of elderly heart failure patients genome wide snp analysis explains coral diversity and recovery in the ryukyu archipelago new theory of okinawan coral migration diversity proposed regulated selection of germinal center cells into the memory b cell compartment mechanism for inducing memory b cell differentiation elucidated riluzole is a radio sensitizing agent in an in vivo model of brain metastasis derived from grm expressing human melanoma cells drug for lou gehrig s disease boosts radiation effectiveness in melanoma laboratory models with brain metastasis a conserved degron containing an amphipathic helix regulates the cholesterol mediated turnover of human squalene monooxygenase a rate limiting enzyme in cholesterol synthesis a spring loaded sensor for cholesterol in cells high fat diet alters prostanoid balance and perfusion in ischemic myocardium of naproxen treated swine possible cardiovascular risk found with nsaid use study suggests markers of celiac disease and gluten sensitivity in children with autism elevated gluten antibodies found in children with autism cerebral organoids derived from sandhoff disease induced pluripotent stem cells exhibit impaired neurodifferentiation sandhoff disease study shows proof of principle for gene therapy tourette syndrome and other tic disorders in childhood adolescence and adulthood tourette syndrome and other tic disorders in children long term persistence and function of hematopoietic stem cell derived chimeric antigen receptor t cells in a nonhuman primate model of hiv aids gene therapy using car t cells could provide long term protection against hiv rapid partial regeneration of brain volume during the first days of abstinence from alcohol recovery of brain volumes with abstinence may vary for different brain regions awakened by cellular stress isolation and characterization of a novel population of pluripotent stem cells derived from human adipose tissue scientists unexpectedly discover stress resistant stem cells in fat tissue removed during liposuction social immunity in amphibians evidence for vertical transmission of innate defenses deadly amphibian disease found in the last disease free region of central america multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation gene crucial to normal development of lungs and brain discovery may lead to new ways to replace damaged lung tissues with stem cells hazard assessment of united arab emirates uae incense smoke pollutants from incense smoke cause human lung cell inflammation bioelectronic modulation of carotid sinus nerve activity in the rat a potential therapeutic approach for type diabetes electronic modulation of carotid sinus nerve can be used as a treatment for type diabetes in rats efficient formal synthesis of oseltamivir phosphate tamiflu with inexpensive d ribose as the starting material toward a less expensive version of the anti flu drug tamiflu the impact of power generation emissions on ambient pm. pollution and human health in china and india eliminating emissions in india and china could add years to people s lives spider dragline silk as torsional actuator driven by humidity spider silk could be used as robotic muscle associations between displayed alcohol references on facebook and problem drinking among college students social media sites may reveal information about problem drinking among college students fat substitutes promote weight gain in rats consuming high fat diets fat substitutes linked to weight gain rats on high fat diet gained more weight after eating low calorie potato chips made with fat substitutes pandemic potential of a strain of influenza a h n early findings swine flu data very consistent with early stages of a pandemic statewide regionalization of postarrest care for out of hospital cardiac arrest association with survival and neurologic outcome new ems system dramatically improves survival from cardiac arrest effects of calcium vitamin d co supplementation on glycaemic control inflammation and oxidative stress in gestational diabetes a randomised placebo controlled trial calcium vitamin d supplementation improves metabolic profile of pregnant women with gestational diabetes electron scale dynamics of the diffusion region during symmetric magnetic reconnection in space earth s magnetotail first ever views of elusive energy explosion office based opioid treatment with buprenorphine obot b statewide implementation of the massachusetts collaborative care model in community health centers medication treatment for opioid use disorders in primary care increases patient access inactivated or live attenuated bivalent vaccines that confer protection against rabies and ebola viruses single vaccines to protect against both rabies and ebola role of green roofs in reducing heat stress in vulnerable urban communities a multidisciplinary approach new study shows ways to maximize temperature lowering benefits of chicago s green roofs patient navigation for comprehensive cancer screening in high risk patients using a population based health information technology system patient navigators improve comprehensive cancer screening rates study finds ad mva therapeutic vaccination with tlr stimulation in siv infected rhesus monkeys new therapeutic vaccine approach holds promise for hiv remission sorghum deoxyanthocyanidin flavonoids confer resistance against corn leaf aphid insect deterring sorghum compounds may be eco friendly pesticide real time two way interaction during st segment elevation myocardial infarction management improves door to balloon times mobile app speeds treatment for heart attack patients ebola virus disease in the democratic republic of the congo early hospitalization key to survival for ebola victims glial cells maintain synapses by inhibiting an activity dependent retrograde protease signal guardians of the synapse scientists identify a new role for nerve supporting cells biodegradable hydrophilic carriers for the oral delivery of hematological factor ix for hemophilia b treatment capsule for severe bleeding disorder moves closer to reality influence of tree species and forest land use on soil hydraulic conductivity and implications for surface runoff generation forest grazing counteracts the effectiveness of trees to reduce flood risk targeted mrna decay by rna binding protein auf regulates adult muscle stem cell fate promoting skeletal muscle integrity gene controls regeneration of injured muscle by adult stem cells conservation of large predator populations demographic and spatial responses of african lions to the intensity of trophy hunting new research reveals extent of human threat to lion populations paternal imprinting of mating preferences between natural populations of house mice mus musculus domesticus mate choice in mice is heavily influenced by paternal cues mouse study shows two levels of waviness are necessary to package the highly extensible nerves in rorqual whales whales use nested russian doll structure to protect nerve tissue during lunge dives carotid intima media thickness in children with ckd results from the ckid study abnormal carotid arteries found in children with kidney disease microrna a p antisense oligonucleotides attenuate osteoarthritis in facet and knee joints potential treatment could stop knee and spine osteoarthritis scientists say the report of the lancet countdown on health and climate change shaping the health of nations for centuries to come climate change and air pollution damaging health and causing millions of premature deaths rich club organization in effective connectivity among cortical neurons like air traffic information flows through neuron hubs in the brain a specific role for tlr in protective th immunity during mucosal infection tlr protein drives immune response to certain food borne illness in mice effects of energy drinks mixed with alcohol on behavioral control risks for college students consuming trendy cocktails drinking energy beverages mixed with alcohol may be riskier than drinking alcohol alone direct evidence of topological defects in electron waves through nanoscale localized magnetic charge scientists use magnetic defects to achieve electromagnetic wave breakthrough incidence of sudden cardiac death in national collegiate athletic association athletes sudden cardiac death affects about in ncaa athletes a year study finds real time transthoracic vector flow imaging of the heart in pediatric patients new imaging method tested for first time on human patients cover crops may cause winter warming in snow covered regions cover crops may increase winter temperatures in north america lipoprotein subclasses and endogenous sex hormones in women at midlife sex hormone levels at midlife linked to heart disease risk in women early retreat of the alaska peninsula glacier complex and the implications for coastal migrations of first americans new deglaciation data opens door for earlier first americans migration a dna barcode assisted annotated checklist of the spider arachnida araneae communities associated to white oak woodlands in spanish national parks broading the biodiversity catalogue of spider populations in the iberian peninsula dna binding alters coactivator interaction surfaces of the intact vdr rxr complex new dna role in modifying gene function findings suggest new approach could create highly targeted therapeutics maternal control of nutrient allocation in plant seeds by genomic imprinting discovery of plant nourishing gene brings hope for increased crop seed yield and food security survival benefit of breast surgery for low grade ductal carcinoma in situ benefit of surgery for ductal carcinoma in situ investigated the impoverished brain disparities in maternal education affect the neural response to sound how poverty molds the brain poor neural processing of sound linked to lower maternal education background global change and the distributional dynamics of migratory bird populations wintering in central america greatest threat to eastern forest birds is habitat loss on wintering grounds tetraplegia is a risk factor for central sleep apnea quadriplegics at risk for serious sleep breathing disorder single dose versus day dose metronidazole for the treatment of trichomoniasis in women an open label randomised controlled trial standard treatment for common std doesn t eliminate parasite in some women the fire ant social chromosome supergene variant sb shows low diversity but high divergence from sb scientists explore the evolution of a social supergene in the red fire ant an analog of the natural steroidal alkaloid cortistatin a potently suppresses tat dependent hiv transcription potent new compound virtually eliminates hiv in cell culture familial linkage between neuropsychiatric disorders and intellectual interests family history of psychiatric disorders shapes intellectual interests study suggests repeatedly pairing vagus nerve stimulation with a movement reorganizes primary motor cortex reorganizing brain could lead to new stroke tinnitus treatments electron diffusion region during magnetopause reconnection with an intermediate guide field magnetospheric multiscale observations nasa mission uncovers a dance of electrons in space luck in food finding affects individual performance and population trajectories animal populations are shrinking due to their high risk food finding strategies longitudinal associations between other sex friendships and substance use in adolescence early male friendship as a precursor to substance abuse in girls progressive cl channel defects reveal disrupted skeletal muscle maturation in r huntington s mice huntington s disease affects muscle as well as neurons study reveals gut microbiome derived metabolites modulate intestinal epithelial cell damage and mitigate graft versus host disease healthy gut could help prevent deadly side effect of bone marrow transplant toddlers prefer those who win but not when they win by force toddlers prefer winners but avoid those who win by force realizing the promise of well being longitudinal research from an effective early intervention program for substance exposed babies and toddlers identifies essential components realizing the promise of education an effective early intervention program for substance exposed babies and toddlers ultraviolet light curves of gaia apd in superluminous supernova models ultraviolet light from superluminous supernova key to revealing explosion mechanism rpap provides a flexible scaffold for coupling hsp to the human r tp co chaperone complex structure of a protein complex related with cell survival revealed no association between proton pump inhibitor use and risk of alzheimer s disease antiulcer drugs do not increase risk of alzheimer s disease chemoselective tarantula toxins report voltage activation of wild type ion channels in live cells tarantula venom illuminates electrical activity in live cells impairment of slc a encoding vesicular glutamate transporter vglut underlies nonsyndromic deafness dfna and inner hair cell dysfunction in null mice inherited form of hearing loss stems from gene mutation hyperthermic laser ablation of recurrent glioblastoma leads to temporary disruption of the peritumoral blood brain barrier laser treatment may boost effectiveness of brain tumor drugs the cosmic gorilla effect or the problem of undetected non terrestrial intelligent signals a cosmic gorilla effect could blind the detection of aliens tumor induced osteoclast mirna changes as regulators and biomarkers of osteolytic bone metastasis small bits of genetic material fight cancer s spread traditional complementary and alternative medicine use in sub saharan africa a systematic review study of traditional medicine finds high use in sub saharan africa despite modern medicine phase sensitive imaging of the outer retina using optical coherence tomography and adaptive optics nanometer scale growth of cone cells tracked in living human eye severe nde mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages in some genetic cases of microcephaly stem cells fail to launch narrow pollen diets are associated with declining midwestern bumble bee species the buzz about bumble bees isn t good erg dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification erg gene key to blood stem cell self renewal batch spawning facilitates transfer of an essential nutrient from diet to eggs in a marine fish the fish and the egg towards a new strategy for fattening up red drum in texas delivery of a drug cache to glioma cells overexpressing platelet derived growth factor receptor using lipid nanocarriers tiny packages may pack powerful treatment for brain tumors perinatal outcomes in multifetal pregnancy following fetal reduction fetal reduction in multifetal pregnancies associated with better birth outcomes jet stream dynamics hydroclimate and fire in california from ce to present wildfire risk in california no longer coupled to winter precipitation family history of myocardial infarction stroke and diabetes and cardiometabolic markers in children one third of children have higher levels of cardiometabolic risk factors due to family history eeg oscillations during word processing predict mci conversion to alzheimer s disease delayed word processing could predict patients potential to develop alzheimer s disease vascular stiffness mechanoactivates yap taz dependent glutaminolysis to drive pulmonary hypertension new understanding of pulmonary hypertension leads to promising drug targets incidence and clearance of oral human papillomavirus infection in men the him cohort study single men smokers at higher risk for oral human papillomavirus infection planting sentinel european trees in eastern asia as a novel method to identify potential insect pest invaders a first in tree research european trees planted in china to identify potentially invasive species in our forests a c orf carm axis regulates lipid metabolism under glucose starvation induced nutrient stress mutation associated with als causes sugar starved cells to overproduce lipids study shows a hot segment based approach for the design of cross amyloid interaction surface mimics as inhibitors of amyloid self assembly amyloid plaques in alzheimer s diabetes novel leads for inhibitors novel method of quantifying radioactive cesium rich microparticles csmps in the environment from the fukushima daiichi nuclear power plant fukushima radioactive particle release was significant says new research environmental dna from seawater samples correlate with trawl catches of subarctic deepwater fishes edna in seawater samples could reveal status of deepwater fish populations molecular orientation control of semiconducting molecules using a metal layer formed by wet processing highly efficient wet processed solar cells with molecules in the same orientation condom access in south african schools law policy and practice south african policy on adolescents rights to access condoms is causing confusion sex specific responses to climate change in plants alter population sex ratio and performance climate change s effect on rocky mountain plant is driven by sex exploring the combined role of eustasy and oceanic island thermal subsidence in shaping biodiversity on the gal pagos how have changing sea levels influenced evolution on the galapagos islands ? an ephb abl signaling pathway is associated with intestinal tumor initiation and growth new knowledge on ephb signaling may improve treatment of intestinal cancers benzothiazole amphiphiles promote the formation of dendritic spines in primary hippocampal neurons neuronal structures associated with memory sprout in response to novel molecules preterm birth and risk of heart failure up to early adulthood preterm birth linked to higher risk of heart failure pathogenic tau induced pirna depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies abnormal gene copying seen in tauopathy fruit fly models nanotopographical cues augment mesenchymal differentiation of human embryonic stem cells stem cell breakthrough could lead to new bone repair therapies on nanoscale surfaces overweight and cpg methylation of the pomc promoter in offspring of high fat diet fed dams are not reprogrammed by regular chow diet in rats how genes link mom s diet to risk of obesity in her offspring the world s largest toothed pterosaur nhmuk r an incomplete rostrum of coloborhynchus capito seeley from the cambridge greensand of england tiny fossil fragment reveals giant but ugly truth part of biggest ever toothed pterosaur from dinosaur era the globalization of tobacco use challenges for the st century global tobacco report outlines challenges for st century hippocampal place cell sequences depict future paths to remembered goals going places rat brain gps maps routes to rewards estimating the global distribution of field size using crowdsourcing crowdsourced field data shows importance of smallholder farms to global food production the interactions between a small molecule and g quadruplexes are visualized by fluorescence lifetime imaging microscopy designer molecule shines a spotlight on mysterious stranded dna flaf is a sandwich protein that anchors the archaellum in the archaeal cell envelope by binding the s layer protein attaching the propeller how the motility structure of unicellular archaea is fixed to their surface recommendations for imaging tumor response in neurofibromatosis clinical trials common outcome measures required for neurofibromatosis clinical trials tube feeding in us nursing home residents with advanced dementia use of feeding tubes decreases among nursing home residents with advanced dementia therapeutic effects of four strains of probiotics on experimental colitis in mice supplement of probiotics provides a new therapy for ulcerative colitis effect of hydrolyzed infant formula vs conventional formula on risk of type diabetes the trigr randomized clinical trial modifying baby formula doesn t prevent type diabetes in children forty years of change in forage fish and jellyfish abundance across greater puget sound washington usa anthropogenic and climate associations populated puget sound sees stark shifts in marine fish species edible dormice glis glis avoid areas with a high density of their preferred food plant the european beech don t move to ensure constant food supply edible dormice rather give up their favourite food long range charge transport in single g quadruplex dna molecules breakthrough in molecular electronics paves way for new generation of dna based computer circuits thermally tunable self healing composites for soft robotic applications squishy robots phase changing material could allow even low cost robots to switch between hard and soft states melanosome transfer to keratinocyte in the chicken embryonic skin is mediated by vesicle release associated with rho regulated membrane blebbing safety in darkness team lays bare melanin s dna guarding mechanism lesbian gay bisexual and transgender adolescent school victimization implications for young adult health and adjustment school bullying violence against lgbt youth linked to risk of suicide hiv infection dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory specific set of nerve cells controls epileptic seizures spread through brain spinal subdural hemorrhage in abusive head trauma a retrospective study spinal bleeding with brain injury may suggest abuse in young children impact of smoking on cognitive decline in early old age the whitehall ii cohort study smoking associated with more rapid cognitive decline in men increasing recognition of happiness in ambiguous facial expressions reduces anger and aggressive behavior seeing happiness in ambiguous facial expressions reduces aggressive behavior systemic neutrophil depletion modulates the migration and fate of transplanted human neural stem cells to rescue functional repair using donor stem cells to treat spinal cord injury the evolution of sexes a specific test of the disruptive selection theory theory of the evolution of sexes tested with algae a yr record of clay mineralogy at lake towuti indonesia paleoclimate reconstruction from reflectance spectroscopy and perspectives on paleolakes on mars paleolake deposits on mars might look like sediments in indonesia gaps and rings in an alma survey of disks in the taurus star forming region unknown treasure trove of planets found hiding in dust an intermediate mass black hole in the centre of the globular cluster tucanae a middleweight black hole is hiding at the center of a giant star cluster gun violence restraining orders alternative or adjunct to mental health based restrictions on firearms ? gun violence restraining orders a promising strategy to reduce gun violence in u.s. naturally occurring versus anthropogenic sources of elevated molybdenum in groundwater evidence for geogenic contamination from southeast wisconsin united states molybdenum in wisconsin wells not from coal ash gene expression profile correlates with t cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy personlized dendritic cell vaccine increases survival in patients with deadly brain cancer risk factors for emergency presentation with lung and colorectal cancers a systematic review older people at higher risk of emergency cancer diagnosis an affinity effect relationship for microbial communities in plant soil feedback loops understanding plant soil interaction could lead to new ways to combat weeds ancient mitochondrial genomes reveal the demographic history and phylogeography of the extinct enigmatic thylacine thylacinus cynocephalus mapping the tasmanian tiger s mysterious loss from mainland rapid automated quantification of cerebral leukoaraiosis on ct images a multicenter validation study artificial intelligence improves stroke and dementia diagnosis in most common brain scan the tlr antagonist eritoran protects mice from lethal influenza infection potential novel treatment for influenza discovered scientists pursue new therapies as deadly h n flu spreads in china metastasis suppressor transcript destabilization through tarbp binding of mrna hairpins discovery of pro metastasis protein reveals mysterious link to neurodegeneration liquid corn and fish fertilizers are good options for fertigation in blackberry cultivars grown in an organic production system liquid corn fish fertilizers good options for organic blackberry production saharan dust nutrients promote vibrio bloom formation in marine surface waters saharan dust affects marine bacteria potential pathogen vibrio generating dna sequence data with limited resources for molecular biology lessons from a barcoding project in indonesia generating dna sequence data in the developing world breast cancer risk after recent childbirth a pooled analysis of prospective studies increased risk for breast cancer after childbirth may last more than years towards improved migraine management determining potential trigger factors in individual patients triggers for migraine attacks determined for individual patients a high resolution model of bat diversity and endemism for continental africa unique high resolution map on bat diversity in africa analysis of combined data sets yields trend estimates for vulnerable spruce fir birds in northern united states avian ecologists combine bird survey data to id vulnerable boreal species paediatric adverse drug reactions following use of asthma medications in europe from to adverse drug reactions in children following use of asthma medications probing the upper band gap of atomic rhenium disulfide layers d materials researchers discover multilayer band gap using its own technology intestinal epithelial toll like receptor prevents metabolic syndrome by regulating interactions between microbes and intestinal epithelial cells in mice mouse study adds to evidence linking gut bacteria and obesity astronomical detection of radioactive molecule alf in the remnant of an ancient explosion pair of colliding stars spill radioactive molecules into space valley floor aeolianite in an equatorial pit crater on mars watery past on mars searching for past life forms propranolol vs corticosteroids for infantile hemangiomas a multicenter retrospective analysis beta blocker associated with better outcomes in treatment of infantile vascular tumors ediacara biota flourished in oligotrophic and bacterially dominated marine environments across baltica ediacara biota flourished in bacterially rich marine habitats topical delivery of avastin to the posterior segment of the eye in vivo using annexin a associated liposomes new innovation could mean eye injections are a thing of the past prenatal fluoride exposure and attention deficit hyperactivity disorder adhd symptoms in children at years of age in mexico city higher levels of urinary fluoride associated with adhd in children the collapse of io s primary atmosphere in jupiter eclipse space scientists observe io s atmospheric collapse during eclipse elevated morning cortisol is a stratified population level biomarker for major depression in boys only with high depressive symptoms first biological marker for major depression could enable better diagnosis treatment prospective cohort study of uterine fibroids and miscarriage risk study disputes link between uterine fibroids and miscarriage risk prevalence of multidrug resistant gram negative bacteria among nursing home residents a systematic review and meta analysis a quarter of nursing home residents are colonized with drug resistant bacteria transcriptomic and genomic evolution under constant cold in antarctic notothenioid fish genes hold secret of survival of antarctic antifreeze fish alternative splicing and highly variable cadherin transcripts associated with field evolved resistance of pink bollworm to bt cotton in india genetic basis of pest resistance to biotech cotton discovered discovery of udp glycosyltransferases and bahd acyltransferases in the biosynthesis of the anti diabetic plant metabolite montbretin a a pretty plant of summer produces a promising anti diabetes compound association of behavior in boys from low socioeconomic neighborhoods with employment earnings in adulthood low income boys inattention in kindergarten associated with lower earnings years later virulence factors enhance citrobacter rodentium expansion through aerobic respiration gut pathogens thrive on body s tissue repair mechanism efficacy and safety of selective serotonin reuptake inhibitors serotonin norepinephrine reuptake inhibitors and placebo for common psychiatric disorders among children and adolescents new study on the placebo effect and antidepressants in children and adolescents the relationship of erectile dysfunction and subclinical cardiovascular disease a systematic review and meta analysis erectile dysfunction is red flag for silent early cardiovascular disease a clinical trial comparing the safety and efficacy of topical tacrolimus versus methylprednisolone in ocular graft versus host disease immunosuppressive medication effectively treats ocular graft versus host disease properties of epitaxial films made of relaxor ferroelectrics physicists provide answers for predicted behavior in relaxors thin films studied used in electronic devices insurance coverage and treatment use under the affordable care act among adults with mental and substance use disorders more with mental illness substance use disorders have health insurance first report offusarium oxysporumf. sp.cubensetropical race associated with panama disease of banana outside southeast asia banana disease spreading panama disease spreads among bananas again two patched molecules engage distinct sites on hedgehog yielding a signaling competent complex advanced microscope technology reveals novel side to cell signaling complex hdl cholesterol efflux capacity and incident cardiovascular events new measurement of hdl cholesterol function provides powerful information about cardiovascular risk haploinsufficiency for core exon junction complex components disrupts embryonic neurogenesis and causes p mediated microcephaly genetic causes of small head size share common mechanism lifestyle modifications for patients with breast cancer to improve prognosis and optimize overall health exercise most important lifestyle change to help reduce risk of breast cancer recurrence raising taxes key to accelerate tobacco control in south asia higher tobacco taxes needed to reduce smoking rates in south asia new analysis says calving cycle of the brunt ice shelf antarctica driven by changes inice shelf geometry large antarctic ice shelf home to a uk research station is about to break apart a machine learned classifier that uses gene expression data to accurately predict estrogen receptor status researchers turn to machines to identify breast cancer type persistence and change in community composition of reef corals through present past and future climates coral reef winners and losers as water temperatures rise increased dna methyltransferase b dnmt b mediated cpg island methylation stimulated by oxidative stress inhibits expression of a gene required for neural tube and neural crest development in diabetic pregnancy new step in molecular pathway found responsible for neural tube defects a birth defect that is increased in diabetic pregnancies partially occluded facial action recognition and interaction in virtual reality applications new technology uses mouth gestures to interact in virtual reality dance related injuries in children and adolescents treated in us emergency departments in increase in dance related injuries in children and adolescents tree growth acceleration and expansion of alpine forests the synergistic effect of atmospheric and edaphic change in eastern tibetan forest signs of tree growth amid climate change long term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type diabetes mellitus four year results of the look ahead trial lifestyle intervention for overweight patients with diabetes provides long term benefits attitudes about mandated coverage of birth control medication and other health benefits in a us national sample more than two thirds of americans support mandated coverage of birth control in health plans an unusual white dwarf star may be a surviving remnant of a subluminous type ia supernova an unusual white dwarf may be a supernova leftover automated risk assessment for school violence a pilot study pilot study validates artificial intelligence to help predict school violence ebola in sierra leone a call for action sierra leone researchers call for improved health surveillance communication around ebola crisis farmer perceptions of climate change associations with observed temperature and precipitation trends irrigation and climate beliefs cooler and wetter study links irrigation to inaccurate climate perception cells alter their trna abundance to selectively regulate protein synthesis during stress conditions cell mechanism regulating protein synthesis in stress conditions discovered nonnutritive sweeteners and cardiometabolic health a systematic review and meta analysis of randomized controlled trials and prospective cohort studies artificial sweeteners linked to risk of weight gain heart disease and other health issues did pre affordable care act medicaid expansion increase access to surgical cancer care ? large pre aca medicaid expansion did not level health disparities in cancer surgery optimization of satellite constellation deployment strategy considering uncertain areas of interest options to optimize profit in broadband satellite constellations targeted inhibitors of p glycoprotein increase chemotherapeutic induced mortality of multidrug resistant tumor cells cells of advanced cancers die with drug like compounds that reverse chemo failure immune mediated pore forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis pore formation in cell membranes linked to triggers of rheumatoid arthritis a longitudinal study of disc height narrowing and facet joint osteoarthritis at the thoracic and lumbar spine evaluated by computed tomography the framingham study one third of people aged have evidence of degenerative disc disease human based systems mechanistic nash modelling just around the corner ? fatty liver disease pandemic needs gold standard human relevant research striatum processes reward differently in adolescents versus adults brain study adolescents brains respond differently than adults when anticipating rewards self reported hearing difficulties and changes in life space mobility among community dwelling older adults a two year follow up study hearing problems reduce quality of life of older people older people remain on blood pressure agents despite being hypotensive resulting in increased mortality and hospital admission many elderly are prescribed antihypertensive medication despite having low blood pressure activating lay health influencers to promote tobacco cessation with training friends and family can help loved ones quit tobacco transcriptomes of parents identify parenting strategies and sexual conflict in a subsocial beetle beetles provide clues about the genetic foundations of parenthood cognitive gains from gist reasoning training in adolescents with chronic stage traumatic brain injury cognitive performance can be improved in teens months years after traumatic brain injury bronchoconstriction triggered by breathing hot humid air in patients with asthma role of cholinergic reflex why hot humid air triggers symptoms in patients with mild asthma alternative progenitor lineages regenerate the adult lung depleted of alveolar epithelial type cells infants born preterm may lack key lung cells later in life evolution and predictive value of ige responses toward a comprehensive panel of house dust mite allergens during the first decades of life molecular origins of allergy to house dust mites discovered a new species of the genus hypleurochilus teleostei blenniidae from trindade island and martin vaz archipelago brazil new species of labrisomidae fish discovered in brazil a new haptoclinus blenny teleostei labrisomidae from deep reefs off cura ao southern caribbean with comments on relationships of the genus a lucky catch a tiny new fish haptoclinus dropi from the southern caribbean drought tolerant species dominate as rainfall and tree cover returns in the west african sahel drought tolerant species thrive despite returning rains in the sahel the oncolytic virus mg targets and eliminates latently hiv infected cells implications for an hiv cure using viruses to fight viruses new approach eliminates dormant hiv infected cells t cell exit from quiescence and differentiation into th cells depend on raptor mtorc mediated metabolic reprogramming researchers discover how protein complex revs up t cell activation to fight infections a novel monoclonal antibody to secreted frizzled related protein inhibits tumor growth novel monoclonal antibody inhibits tumor growth in breast cancer and angiosarcoma a hybrid human machine interface for hands free control of an intelligent wheelchair take control of a wheelchair with a steady jaw and a wink drinking behavior among low income older adults a multimethod approach to estimating alcohol use sorting through recycling bins to learn about alcohol use an evidence based discussion of heading the ball and concussions in high school soccer heading the ball player to player contact and concussions in high school soccer gene targeting to rods dose dependent efficiency and complications associated with different promoters gene therapy sets stage for new treatments for inherited blindness reduced levels of mirnas and in sperm of mice and men exposed to early life stress early life trauma in men associated with reduced levels of sperm micrornas effect of losartan on mitral valve changes after myocardial infarction medical treatment may prevent alleviate mitral valve damage after a heart attack hmc in the brain is abundant in synaptic genes and shows differences at the exon intron boundary roles of novel epigenetic chemical in the brain illuminated breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts new breast cancer stem cell findings explain how cancer spreads deformation from the loma prieta earthquake near the southwest margin of the santa clara valley california understanding the loma prieta earthquake in an urban context hospitalizations due to selected infections caused by opportunistic premise plumbing pathogens oppp and reported drug resistance in the united states older adult population in healthcare costs for infections linked to bacteria in water supply systems are rising changes of cell biochemical states are revealed in protein homomeric complex dynamics new lead for mechanism of action of diabetes drug metformin physical activity over the life course and its association with cognitive performance and impairment in old age teenage physical activity reduces risk of cognitive impairment in later life antibiotic prescription and food allergy in young children young children s antibiotic exposure associated with higher food allergy risk the effect of oxytocin nasal spray on social interaction deficits observed in young children with autism a randomized clinical crossover trial oxytocin has social emotional and behavioral benefits in young kids with autism posttraumatic stress disorder is associated with worse endothelial function among veterans ptsd may affect blood vessel health in veterans identification and functional analyses of sex determination genes in the sexually dimorphic stag beetle cyclommatus metallifer unraveling the genes for sexual traits in stag beetles turkey husbandry and use in oaxaca mexico a contextual study of turkey remains and sem analysis of eggshell from the mitla fortress archaeological excavation unearths evidence of turkey domestication years ago assembly of the ebola virus nucleoprotein from a chaperoned vp complex new close up view of key part of ebola virus life cycle injuries at the whistler sliding center a year retrospective study safety of whistler sliding track comparable to other tracks radiological and genetic analysis of a late iron age mummy from the tuli block botswana first successful extraction of ancient dna from a southern african mummy binge drinking induces whole body insulin resistance by impairing hypothalamic insulin action binge drinking increases risk of type diabetes by causing insulin resistance kit regulates hsc engraftment across the human mouse species barrier opening up the stem cell niche hematopoietic stem cell transplantation without irradiation multifocal clonal evolution characterized using circulating tumour dna in a case of metastatic breast cancer dna in blood can track cancer development response in real time the position of neuromuscular patients in shared decision making. report from the th enmc workshop milan italy january expand the role of patients the true experts in neuromuscular disease research topically applied tenofovir in humanized blt mice using the caprisa experimental design demonstrates partial protection from vaginal hiv infection validating the blt model for the evaluation of new microbicide candidates preventing the spread of hiv aids with humanized blt mice new criteria for the molecular identification of cereal grains associated with archaeological artefacts archaeologists find key to tracking ancient wheat in frozen bronze age box the mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase lycat is a novel target in pulmonary fibrosis protein molecule may improve survival in deadly lung disease factors influencing parental involvement among minors seeking an abortion a qualitative study young women involve parent in abortion when anticipating support maternal smoking in pregnancy and asthma in preschool children a pooled analysis of birth cohorts smoking in pregnancy increases asthma risk in preschool gaba from reactive astrocytes impairs memory in mouse models of alzheimer s disease discovery of new drug targets for memory impairment in alzheimer s disease computer aided discovery of debris disk candidates a case study using the wide field infrared survey explorer wise catalog computer searches telescope data for evidence of distant planets imaging dynamics of cd c cells and foxp cells in progressive autoimmune insulitis in the nod mouse model of type diabetes imaging the development of diabetes visualization of a human autoimmune disease in animal models the role of den quality in giant panda conservation tree dens play a critical role in panda lifestyle neuromonitoring with pulse train stimulation for implantation of thoracic pedicle screws a blinded and randomized clinical study. part. methods and alarm criteria neuromonitoring with pulse train stimulation for implantation of thoracic pedicle screws rabies outbreaks and vaccination in domestic camels and cattle in northwest china of dogs foxes cows camels and men the fight against rabies in northern china how hives collapse allee effects ecological resilience and the honey bee honeybee hive collapse mystery rooted in hive size receptor tyrosine kinase erbb mediates acquired resistance to erbb inhibitors in breast cancer cells new mechanism of acquired resistance to breast cancer drugs genetically mediated associations between measures of childhood character and academic achievement. genetics play role in character traits related to academic success vitamin d race and cardiovascular mortality findings from a national us sample study links vitamin d race and cardiac deaths functional cortical neurons and astrocytes from human pluripotent stem cells in d culture a patient s budding cortex in a dish ? networking neurons thrive in d human organoid radical alkyne peri annulations for synthesis of functionalized phenalenes benzanthrenes and olympicene researchers achieve olympic ring molecule breakthrough just in time for winter games physical therapy as the first point of care to treat low back pain an instrumental variables approach to estimate impact on opioid prescription health care utilization and costs early physical therapy benefits low back pain patients the combination of lithium and l dopa carbidopa reduces mptp induced abnormal involuntary movements aims via calpain inhibition in a mouse model relevance for parkinson s disease therapy low dose lithium reduces side effects from most common treatment for parkinson s disease full in vivo characterization of carbonate chemistry at the site of calcification in corals full carbonate chemistry at the site of calcification in a tropical coral combination therapy with anti hiv antibodies maintains viral suppression combination antibody therapy results in long term viral suppression in hiv infection containing big soda countering inducements to buy large size sugary drinks policymakers need to look at wider economic benefits of taxing sugary drinks pde inhibitor efficacy is estrogen dependent in female heart disease gender differences stand out in measuring impact of viagra as therapy for heart failure breast cancer statistics convergence of incidence rates between black and white women breast cancer becoming as common among african american women as among white women gut microbiome mediated bile acid metabolism regulates liver cancer via nkt cells gut microbiome can control antitumor immune function in liver direct observation of a two dimensional hole gas at oxide interfaces materials mystery key to next generation electronic devices solved trends in seniors use of digital health technology in the united states low rate of internet use by seniors for health purposes the trade off between optimizing flight patterns and human health a case study of aircraft noise in queens ny usa optimizing airport flight patterns take a toll on human health hyaluronic acid serum hydrogels rapidly restore metabolism of encapsulated stem cells and promote engraftment sticky gel helps stem cells heal rat hearts can emotion regulation change political attitudes in intractable conflicts ? from the laboratory to the field reappraisal defuses strong emotional responses to israel palestine conflict bleaching causes loss of disease resistance within the threatened coral species acropora cervicornis coral bleaching increases disease risk in threatened species notes on the nesting of three species of megachilinae in the dubai desert conservation reserve uae bee species with little known nesting behavior observed to use plastic instead of leaves lipid phosphate phosphatase expression in cancer cells attenuates tumor growth and metastasis in mice researchers stop vicious cycle of inflammation that leads to tumor growth gain of toxic apolipoprotein e effects in human ipsc derived neurons is ameliorated by a small molecule structure corrector scientists fix genetic risk factor for alzheimer s disease in human brain cells the tplate adaptor complex drives clathrin mediated endocytosis in plants plants recycle too biologists have now identified a new protein complex which is crucial for endocytosis in plants physicians recommend different treatments for patients than they would choose for themselves physicians recommend different treatments for patients than they choose for themselves study finds transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain study points to new method to deliver drugs to the brain phytosterols promote liver injury and kupffer cell activation in parenteral nutrition associated liver disease likely culprit behind liver problems linked to intravenous feeding sustained akt activity is required to maintain cell viability in seborrheic keratosis a benign epithelial tumor first topical treatment for common benign skin lesions women s health behaviours and psychosocial well being by cardiac rehabilitation program model a randomized controlled trial reduced anxiety depression for women participating in women only cardiac rehab programs distinct representations of basic taste qualities in human gustatory cortex the sweet spot scientists discover taste center of human brain implications of aligning full registration of doctors with medical school graduation a qualitative study of stakeholder perspectives more hands on training for doctors required if policy changes quantum critical regime in a quadratically driven nonlinear photonic lattice in a new quantum simulator light behaves like a magnet circadian clock control by polyamine levels through a mechanism that declines with age diet supplement keeps circadian clock from slowing down in aging mice an articulated cervical series ofalamosaurus sanjuanensisgilmore dinosauria sauropoda from texas new perspective on the relationships of north america s last giant sauropod massive vertebrae sheds new light on alamosaurus sanjuanensis differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging mapping brain circuits in newborns may aid early detection of autism theory of magnetism driven negative thermal expansion in inverse perovskite antiferromagnets first explanation for mechanism behind magnetism driven nte derived in years regional coral responses to climate disturbances and warming is predicted by multivariate stress model and not temperature threshold metrics new climate stress index model challenges doomsday forecasts for world s coral reefs risk for preterm and very preterm delivery in women who were born preterm new risk factor for pregnancies higher risk of preterm delivery for women born preterm high temperature induced defects in tomato solanum lycopersicum anther and pollen development are associated with reduced expression of b class floral patterning genes tomato plant s male reproduction organs shrivel under high temperatures energetic regulation of coordinated leader follower dynamics during collective invasion of breast cancer cells like racecars and geese cancer cells draft their way to new tumor sites nonintegral stoichiometry in cftr gating revealed by a pore lining mutation new insights into functionality of cystic fibrosis protein extraordinary plasticity of an inorganic semiconductor in darkness keep the light off a material with improved mechanical performance in the dark tracing ancient human migrations into sahul using hepatitis b virus genomes hepatitis b virus sheds light on ancient human population movements into australia dramatic increase in autism prevalence parallels explosion of research into its biology and causesautism prevalence research into biology causes dramatic rise in autism prevalence parallels research explosion a fast quantum interface between different spin qubit encodings hybrid qubits solve key hurdle to quantum computing increased risk of psychiatric disorders in allergic diseases a nationwide population based cohort study asthma and hay fever linked to increased risk of psychiatric disorders efficacy of an internet based depression intervention to improve rates of treatment in adolescent mothers online intervention improves depression treatment rates in teen moms ipec j mdr a novel high resistance cell line with functional expression of human p glycoprotein abcb for drug screening studies researchers develop novel cell line for screening of brain drugs transforming communication and safety culture in intrapartum care a multi organization blueprint multi organization call to action identifies addresses safety concerns in labor and delivery estimates of pandemic influenza vaccine effectiveness in europe results of influenza monitoring vaccine effectiveness in europe i move multicentre case control study pandemic h n influenza vaccine effective in flu season herbivores as drivers of negative density dependence in tropical forest saplings pests and the plant defenses against them drive diversity in tropical rainforests eating disorder symptoms and weight and shape concerns in a large web based convenience sample of women ages and above results of the gender and body image gabi study eating disorder behaviors and weight concerns are common in women over discovery of circa year old bone retouchers at lingjing henan china discovery of sophisticated year old bone tools in china pilot evaluation of physical and psychological effects of a physical trek programme including a dog sledding expedition in children and teenagers with cancer dog sledding offers a healthy dose of adventure for children with cancer vascular factors and markers of inflammation in offspring with a parental history of late onset alzheimer disease high blood pressure and markers of inflammation in blood more common in offspring of parents with alzheimer s disease sugar intake from sugar sweetened beverage among cancer and non cancer individuals the nhanes study more information on how cancer and sugar sweetened beverages are link analysis of five chronic inflammatory diseases identifies new associations and highlights disease specific patterns at shared loci global study reveals genes as major cause of inflammatory diseases human defensin promotes mucosal innate immunity through self assembled peptide nanonets immune system molecule weaves cobweb like nanonets to snag salmonella other intestinal microbes reactivation of dormant relay pathways in injured spinal cord by kcc manipulations paralyzed mice with spinal cord injury made to walk again play to become a surgeon impact of nintendo wii training on laparoscopic skills wii playing surgeons may improve performance on laparoscopic procedures predation of desmodus rotundus geoffroy phyllostomidae chiroptera by epicrates cenchria linnaeus boidae reptilia in an ecuadorian cave rainbow boa preying on a vampire bat in a cave in ecuador a half second glimpse often lets radiologists identify breast cancer cases even when viewing the mammogram of the opposite breast radiologists detect breast cancer in blink of an eye adhd symptoms are associated with lower adaptive behavior skills in children with autism children with autism co occurring adhd symptoms lag in key measures of independence an off target effect of bx blocks herpes simplex virus type infection of the eye a new class of drug to treat herpes simplex virus infection phylogenetics of a fungal invasion origins and widespread dispersal of white nose syndrome using genomics to determine origins of deadly white nose syndrome advancing the evidence base and transforming cancer care through interprofessional collegiality the society for integrative oncology report card on complementary therapies for breast cancer skin inspired open mesh electrochemical sensors for lactate and oxygen monitoring wearable sensors mimic skin to help with wound healing process quantitative imaging of cell membrane associated effective mass density using photonic crystal enhanced microscopy pcem researchers explore essential cell behavior with crystal sensor patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune related genes genetic mutations found linked to rare cases of multiple bowel tumors understanding drivers of antibiotic resistance genes in high arctic soil ecosystems study reveals unsettling multidrug antibiotic resistance in remote arctic soil microbes a selective protein based fluorescent sensor with picomolar affinity for rare earth elements new sensor detects rare metals used in smartphones efficacy of live attenuated influenza vaccine in children against influenza b viruses by lineage and antigenic similarity building a better flu vaccine add second strain of influenza b an observational study of associations among maternal fluids during parturition neonatal output and breastfed newborn weight loss maternal iv fluids linked to newborns weight loss consistency of nutrition recommendations for foods marketed to children in the united states some video games promote unhealthy foods for kids effects of long term sertraline treatment and depression on coronary artery atherosclerosis in premenopausal female primates common antidepressant increased coronary atherosclerosis in animal model deep water formation in the north pacific during the last glacial termination north pacific global backup generator for past climate change improving the design of a conservation reserve for a critically endangered species expansion of australian reserves for fairy possums might be at expense of other species measuring vaccine confidence introducing a global vaccine confidence index the state of vaccine confidence early results of a vaccine confidence index in vivo imaging of dendritic pruning in dentate granule cells adult brain prunes branched connections of new neurons childhood behavior problems and academic outcomes in adolescence longitudinal population based study higher levels of inattention at age seven linked with lower final high school exam grades xbp promotes triple negative breast cancer by controlling the hif pathway gene implicated in progression relapse of deadly breast cancer finding points to potential achilles heel in triple negative breast cancer cross linked cellulose nanocrystal aerogels as viable bone tissue scaffolds from foam to bone plant cellulose can pave the way for healthy bone implants generation of scalable metallic high aspect ratio nanocomposites in a biological liquid medium synthesis of a new nanomaterial self assembly may work within the body efficacy of a leptin receptor antagonist peptide in a mouse model of triple negative breast cancer new peptide could be effective treatment for triple negative breast cancer key provisions of the patient protection and affordable care act aca a systematic review and presentation of early research findings affordable care act has improved access to health care but disparities persist aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size mutant ferrets offer clues to human brain size antibody to poly n acetyl glucosamine provides protection against intracellular pathogens mechanism of action and validation in horse foals challenged with rhodococcus equi breakthrough in the hunt for a vaccine against foal pneumonia implications of centers for medicare medicaid services severe sepsis and septic shock early management bundle and initial lactate measurement on the management of sepsis each hour of delay in detecting abnormal lactates in patients with sepsis increases the odds of in hospital death risk of premature menopause after treatment for hodgkin s lymphoma scientists map risk of premature menopause after cancer treatment efficacy of prosultiamine treatment in patients with human t lymphotropic virus type i associated myelopathy tropical spastic paraparesis results from an open label clinical trial nervous system disease a new outlet for an old drug ? antibacterial envelope to prevent cardiac implantable device infection absorbable antibiotic envelope can significantly cut cardiac device infections simulation as part of discharge teaching for parents of infants in the neonatal intensive care unit facing nightmare scenarios before discharge lifts confidence of parents of babies in nicu immune perturbations in hiv infected individuals who make broadly reactive neutralizing antibodies. scientists identify immunological profiles of people who make powerful hiv antibodies neck circumference percentile a screening tool for pediatric obstructive sleep apnea new screening tool to diagnose common sleep problem in children preferences for end of life care among community dwelling older adults and patients with advanced cancer a discrete choice experiment preferences for a good end of life experience salient features of otoacoustic emissions are common across tetrapod groups and suggest shared properties of generation mechanisms owls lizards lend their ears for human hearing research prosper delivery of universal preventive interventions with young adolescents long term effects on emerging adult substance misuse and associated risk behaviors young adult substance abuse down significantly among prosper program participants correction of thalassemia major by gene transfer in hematopoietic progenitors of pediatric patients gene therapy breakthrough heralds treatment for beta thalassemia the right way to kiss directionality bias in head turning during kissing humans hardwired to lean to the right while kissing the world over personality related survival and sampling bias in wild cricket nymphs differences in personality influence survival in field crickets excess under female mortality across india a spatial analysis using census data gender discrimination results in the deaths of extra girls per year in india construction of a live attenuated hiv vaccine through genetic code expansion new approach to hiv vaccine explored by scientists changes in european wind energy generation potential within a. c warmer world european wind energy generation potential in a. degree c warmer world fox sightings in a city are related to certain land use classes and sociodemographics results from a citizen science project foxes in the city citizen science helps researchers to study urban wildlife the population health benefits of a healthy lifestyle life expectancy increased and onset of disability delayed a healthy lifestyle increases life expectancy by up to seven years physical level synthesis for digital lab on a chip considering variation contamination and defect a lab in your pocket using cad to load dozens of tests on a lab on a chip the fecal metabolome in hmga transgenic mice with polyposis evidence for potential screen for early detection of precursor lesions in colorectal cancer fat in feces points to early presence of colorectal cancer the probacterial effect of type i interferon signaling requires its own negative regulator usp double agent in the immune system may make us vulnerable to bacterial infections ants farm subterranean aphids mostly in single clone groups an example of prudent husbandry for carbohydrates and proteins ? ants farm root aphid clones in subterranean rooms the relationship between cell phone use academic performance anxiety and satisfaction with life in college students frequent cell phone use linked to anxiety lower grade reduced happiness in students sapc dops nanovesicles as targeted therapy for lung cancer lung cancer may be treatable with use of sapc dops technology research shows simbakubwa kutokaafrika gen. et sp. nov. hyainailourinae hyaenodonta creodonta mammalia a gigantic carnivore from the earliest miocene of kenya fossils found in museum drawer in kenya belong to gigantic carnivore cerebral microbleeds in multiple sclerosis evaluated on susceptibility weighted images and quantitative susceptibility maps a case control study cerebral microbleeds in ms are associated with increased risk for disability prevention of siv rectal transmission and priming of t cell responses in macaques after local preexposure application of tenofovir gel rectal gel prevents transmission of aids like virus in macaques the nlrp sensor negatively regulates autoinflammatory disease by modulating interleukin production in t cells protein identified that serves as a brake on inflammation cdk coordinates jak v f mutant mpn via nf b and apoptotic networks malignant bone marrow disease new hope for mpn patients clinically important body weight gain following knee arthroplasty a five year comparative cohort study knee replacement surgery may lead to weight gain topological analyses in app ps mice reveal that astrocytes do not migrate to amyloid plaques geometric study of brain cells could change strategies on alzheimer s consequences of warming on tundra carbon balance determined by reindeer grazing history reindeer grazing may counteract effects of climate warming on tundra carbon sink higher resilience to climatic disturbances in tropical vegetation exposed to more variable rainfall amazon forest areas with higher rainfall variability are more resilient to climate change personalized cancer vaccine platform for clinically relevant oncolytic enveloped viruses new cancer vaccine platform a potential tool for efficacious targeted cancer therapy low income ethnically diverse children s engagement as a predictor of school readiness above preschool classroom quality positive engagement in preschool key to developmental gains progranulin functions as a cathepsin d chaperone to stimulate axonal outgrowth in vivo shortage of progranulin is a frequent cause of frontotemporal dementia bioaerosol sampling for respiratory viruses in singapore s mass rapid transit network potential role of bioaerosol sampling in disease surveillance the association of vitamin d status with pediatric critical illness first pediatric study to look at the role of vitamin d in critical illness a defined glycosaminoglycan binding substratum for human pluripotent stem cells embryonic stem cell culturing grows from art to science crtc function during memory encoding is disrupted in neurodegeneration new research points to potential treatment for memory loss activating a protein dysregulated in dementia male fertility and obesity are ghrelin leptin and glucagon like peptide pharmacologically relevant ? obesity and male infertility a global health problem physical activity levels and psychosis a mediation analysis of factors influencing physical activity target achievement among people across low and middle income countries investigating the relationship between low physical activity and psychotic symptoms glutamatergic regulation prevents hippocampal dependent age related cognitive decline through dendritic spine clustering existing drug riluzole may prevent foggy old age brain research shows ectopic colonization of oral bacteria in the intestine drives th cell induction and inflammation oral bacteria in the gut could drive immune cell induction and inflammatory bowel disease fluorescent neuraminidase assay based on supramolecular dye capture after enzymatic cleavage dye makes flu germs visible to the naked eye outcomes after hip fracture surgery compared with elective total hip replacement factors for higher risk of death following hip fracture surgery than hip replacement mitochondrial replacement techniques implications for the clinical community clinical community has crucial role to play in the future of mitochondrial replacement techniques say experts exome sequencing identifies gene variants and networks associated with extreme respiratory outcomes following preterm birth new genetic pathways linked to severe lung disease in preemies a heart and a mind self distancing facilitates the association between heart rate variability and wise reasoning wisdom is a matter of both heart and mind research finds catestatin inhibits obesity induced macrophage infiltration and inflammation in the liver and suppresses hepatic glucose production leading to improved insulin sensitivity peptide improves glucose and insulin sensitivity lowers weight in mice giant spin splitting and gap renormalization driven by trions in single layer ws h bn heterostructures x ray experiments suggest high tunability of d material saline groundwater from coastal aquifers as a source for desalination groundwater from coastal aquifers is a better source for desalination than seawater efficient removal of recalcitrant deep ocean dissolved organic matter during hydrothermal circulation deep sea hydrothermal vents have carbon removing properties prognostic value of grip strength findings from the prospective urban rural epidemiology pure study testing hand grip strength could be a simple low cost way to predict heart attack and stroke risk pediatric non down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes new treatment recommendations for a high risk pediatric leukemia the effect of vitamin c on bronchoconstriction and respiratory symptoms caused by exercise a review and statistical analysis vitamin c may help people who suffer from airway obstruction or respiratory symptoms after exercise a randomized placebo controlled trial of acupuncture in patients with chronic obstructive pulmonary disease copd the copd acupuncture trial cat acupuncture appears linked with improvement in patients with chronic obstructive pulmonary disease does increased urination frequency protect against bladder cancer ? frequent urination protects against bladder cancer study finds on engagement with anthropology a critical evaluation of skeletal and developmental abnormalities in the atacama preterm baby and issues of forensic and bioarchaeological research ethics. response to bhattacharya et al. whole genome sequencing of faulty science and ethics cited in dna analyzes of atacama mummy gravitational demand on the neck musculature during tablet computer use tablet use significance of usage position potential for neck damage metabolic properties in stroked rats revealed by relaxation enhanced magnetic resonance spectroscopy at ultrahigh fields mri machine provides in depth analysis of strokes positive psychological factors are associated with lower ptsd symptoms among police officers post hurricane katrina positive personality traits may protect police at high risk for ptsd impact of tobacco related health warning labels across socioeconomic race and ethnic groups results from a randomized web based experiment graphic warnings on cigarettes effective across demographic groups weight loss attitudes and social forces in urban poor black and white women obese black and white women differ in how they view weight association of us centers for medicare and medicaid services hospital day risk standardized readmission metric with care quality and outcomes after acute myocardial infarction readmission penalties don t correlate to heart attack outcomes school performance at age in children exposed to antiepileptic drugs in utero a population based study teens of epileptic moms display poor school performance study finds a juvenile mouse pheromone inhibits sexual behaviour through the vomeronasal system tears for fears juvenile mice secrete a protective pheromone in their tears blocking adult mating arginine deprivation and immune suppression in a mouse model of alzheimer s disease new potential cause for alzheimer s arginine deprivation caused by overconsumption by immune cells lipid based diets improve muscarinic neurotransmission in the hippocampus of transgenic appswe ps de mice lipid based diets effectively combat alzheimer s disease in mouse model genomic fossils reveal adaptation of non autonomous pararetroviruses driven by concerted evolution of noncoding regulatory sequences genetic fossils reveal long term viral partnerships in grass interplay of matrix stiffness and protein tethering in stem cell differentiation bioengineers matrix stiffness is essential tool in stem cell differentiation cost effectiveness of continuous glucose monitoring for adults with type diabetes compared with self monitoring of blood glucose the diamond randomized trial diabetes continuous glucose monitors proven cost effective add to quality of life for diabetics score report effect of bevacizumab versus aflibercept on visual acuity among patients with macular edema due to central retinal vein occlusion avastin as effective as eylea for treating central retinal vein occlusion hormone use reproductive history and risk of lung cancer no association between lung cancer risk in women reproductive history or hormone use therapeutic efficacy of potent neutralizing hiv specific monoclonal antibodies in shiv infected rhesus monkeys monoclonal antibodies show promise as effective hiv therapy invasive non typhoidal salmonella infections in asia clinical observations disease outcome and dominant serovars from an infectious disease hospital in vietnam risk factors features and outcomes of invasive non typhoidal salmonella in vietnam a unique mating strategy without physical contact during fertilization in bombay night frogs nyctibatrachus humayuni with the description of a new form of amplexus and female call discovery of a new mating position in frogs tensiomyography of selected lower limb muscles in professional soccer players muscle response of soccer players depends on their position on the field efficacy of selected insecticides applied to hybrid rice seed entomologists report on benefits of neonicotinoid seed treatments on rice stomaching the possibility of a pathogenic role for helicobacter pylori in parkinson s disease eradicating helicobacter pylori infections may be a key treatment for parkinson s disease chemical hybridization of glucagon and thyroid hormone optimizes therapeutic impact for metabolic disease personalized medicine smart drug clears fat from liver blood factors associated with concussion like symptom reporting in high school athletes study examines concussion like symptom reporting in uninjured athletes evidence for declining forest resilience to wildfires under climate change forest resilience declines in face of wildfires climate change high resolution analysis with novel cell surface markers identifies routes to ips cells stem cell study could aid quest to combat range of diseases induction of apoptosis in human cancer cells by candidaspongiolide a novel sponge polyketide natural chemical from sea sponges induces death in cancer cells via unusual pathway antioxidants for alzheimer disease a randomized clinical trial with cerebrospinal fluid biomarker measures clinical trial examines antioxidant effects for alzheimer s disease on cerebrospinal fluid biomarkers inferring allele frequency trajectories from ancient dna indicates that selection on a chicken gene coincided with changes in medieval husbandry practices holy chickens did medieval religious rules drive domestic chicken evolution ? progress in physical activity over the olympic quadrennium increase in physical activity lags despite calls to step it up during the olympics empathy for social exclusion involves the sensory discriminative component of pain a within subject fmri study the pain of social exclusion physical pain brain circuits activated by social pain age dependent effects of apoe reduction using antisense oligonucleotides in a model of amyloidosis alzheimer s damage in mice reduced with compound that targets apoe gene restoration of high sensitivity and adapting vision with a cone opsin with single gene insertion blind mice regain sight inhibition of prolyl oligopeptidase restores spontaneous motor behavior in the synuclein virus vector based parkinson s disease mouse model by decreasing synuclein oligomeric species in mouse brain re search ers cor rect par kin son s mo tor symp toms in mice preoperative serum cholesterol is an independent prognostic factor for patients with renal cell carcinoma rcc low cholesterol linked with worse survival in patients with kidney cancer genetic inactivation of the polycomb repressive complex in t cell acute lymphoblastic leukemia new culprit discovered in t cell acute lymphoblastic leukemia monitoring of serum dna methylation as an early independent marker of response and survival in metastatic breast cancer tbcrc prospective biomarker study blood test that detects changes in tumor dna predicts survival of women with advanced breast cancer transcriptome patterns in hidradenitis suppurativa support for the role of antimicrobial peptides and interferon pathways in disease pathogenesis dermcidin may play role in the pathogenesis of skin disease hidradenitis suppurativa accumulation and distribution of marine debris on barrier islands across the northern gulf of mexico marine debris study counts trash from texas to florida ancient fennoscandian genomes reveal origin and spread of siberian ancestry in europe first ancient dna from mainland finland reveals origins of siberian ancestry in region hemoglobin differences by race in children with ckd anemia tougher to tackle in black children with kidney disease study finds fluctuating selection on migrant adaptive sodium transporter alleles in coastal arabidopsis thaliana gene identified with a key role in plant adaptation to fluctuating soil salinity levels optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer stockholm iii a multicentre randomised non blinded phase non inferiority trial new method reduces adverse effects of rectal cancer treatment a null test of general relativity based on a long term comparison of atomic transition frequencies atomic clock comparison confirms key assumptions of einstein s elevator structural basis for lar rptp slitrk complex mediated synaptic adhesion structure of neuron connecting synaptic adhesion molecules discovered poly ethylene glycol poly lysine block copolymer ubenimex conjugate targets aminopeptidase n and exerts an antitumor effect in hepatocellular carcinoma stem cells anticancer drugs delivered by a new drug delivery system reduce tumor size a new cell culture model to genetically dissect the complete human papillomavirus life cycle scientists design new skin cell culture technique to study human papillomavirus plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond ldl cholesterol first in u.s. blood test that assesses risk of heart attack using plasma ceramides sufex click chemistry enabled late stage drug functionalization click chemistry reactions may boost cancer fighting drug potency the preferential targeting of the diseased microvasculature by disk like particles zeroing in on the best shape for cancer fighting nanoparticles hospitalization for underage drinkers in the united states hospitalization of us underage drinkers common costs million a year comparison of the effects of glycerol dimethyl sulfoxide and hydroxyethyl starch solutions for cryopreservation of avian red blood cells research points to effective methods of freezing avian red blood cells disparities in the use of breast conserving therapy among patients with early stage breast cancer breast conserving therapy for early stage cancers has increased substantially though access remains an issue dysregulation in actin cytoskeletal organization drives increased stiffness and migratory persistence in polyploidal giant cancer cells first study on physical properties of giant cancer cells may inform new treatments reading fluency in school aged children with bilateral astigmatism wearing glasses improves reading fluency for kids with high astigmatism chip based brillouin processing for carrier recovery in self coherent optical communications photonic chips harness sound waves to speed up local networks fiddler on the roof a northern range extension for the marsh fiddler crab uca pugnax fiddler crab migrating north possibly from climate change wider impacts of a week community cooking skills program jamie s ministry of food australia jamie s ministry of food brings about changes in food attitudes behaviors the hit phenomenon a mathematical model of human dynamics interactions as a stochastic process physicists predict success of movies at the box office based solely on advertising costs associations between macronutrient intake and obstructive sleep apnoea as well as self reported sleep symptoms results from a cohort of community dwelling australian men fatty diets lead to daytime sleepiness poor sleep regulator of g protein signaling rgs suppresses premature calcium release in mouse eggs researchers identify protein in mice that helps prepare for healthy egg sperm union empirical evidence that metabolic theory describes the temperature dependency of within host parasite dynamics a method for predicting the impact of global warming on disease dynamical system modeling of immune reconstitution after allogeneic stem cell transplantation identifies patients at risk for adverse outcomes researchers identify patients at risk for stem cell transplant complications some coral diseases track climate oscillations in the caribbean coral disease outbreaks fluctuate with el ni o years new research finds evolutionary population history of early paleoamerican cranial morphology ancient humans arrived in south america in multiple waves brd regulates metastatic potential of castration resistant prostate cancer through ahnak protein that hinders advancement of prostate cancer identified neuropathologic assessment of dementia markers in identical and fraternal twins after death twin brains show similar patterns of neuropathologic changes high resolution record reveals climate driven environmental and sedimentary changes in an active rift drilling results reveal global climate influence on basin waters in young rifts interrogating the genetic determinants of tourette s syndrome and other tic disorders through genome wide association studies major genetic study confirms that many genes contribute to risk for tourette s syndrome incidence and costs of neonatal abstinence syndrome among infants with medicaid impact of neonatal abstinence syndrome on state medicaid programs two year trends and predictors of e cigarette use in european union member states e cigarette use in uk almost doubled in years says europe wide study improving outcomes in colorectal surgery by sequential implementation of multiple standardized care programs new care approach to colorectal operations speeds patients recovery times on line voluntary control of human temporal lobe neurons controlling individual cortical nerve cells by human thought insights into modern human prehistory using ancient genomes ancient eurasian dna sequencing is revealing links with modern humans a computational framework for personalized blood flow analysis in the human left atrium corkscrew shape of blood flow in heart s upper chamber may signal lower stroke risk mortality rates in patients with anorexia nervosa and other eating disorders a meta analysis of studies patients with eating disorders have an elevated rate of death falls predict fractures independently of frax probability a meta analysis of the osteoporotic fractures in men mros study past falls can help predict an individual s risk of bone fracture independent of other factors grp associated scaffold protein regulates skin homeostasis after ultraviolet irradiation genetic function of tumor suppressor gene discovered could offer new avenue to cancer therapies incidence of emergency department visits for st elevation myocardial infarction in a recent six year period in the united states american decline in one type of serious heart attack cognitive improvement after mild traumatic brain injury measured with functional neuroimaging during the acute period researchers use neuroimaging to measure early cognitive improvement after mild tbi rare variants of large effect in brca and chek affect risk of lung cancer smokers with gene defect have one in four chance of developing lung cancer space borne bose einstein condensation for precision interferometry bose einstein condensate generated in space for the first time high dietary acid load predicts esrd among adults with ckd high acid diet may have negative effects on kidney health tracking the market performance of companies that integrate a culture of health and safety study strengthens link between stock market performance and employee health and safety programs a majority of hiv persistence during antiretroviral therapy is due to infected cell proliferation majority of hiv persistence during art due to infected cell proliferation corticosteroid use during pregnancy and risk of orofacial clefts corticosteroid use during pregnancy not linked to facial clefts in infants study finds achieving mitigation and adaptation to climate change through sustainable agroforestry practices in africa agroforestry can ensure food security mitigate effects of climate change in africa compensation of ocean acidification effects in arctic phytoplankton assemblages phytoplankton assemblages in coastal waters remain productive despite variable environmental conditions inflammasome driven catecholamine catabolism in macrophages blunts lipolysis during ageing battling belly fat specialized immune cells impair metabolism in aging treatment for epilepsy in pregnancy neurodevelopmental outcomes in the child expectant mothers with epilepsy face tough choices over their medication genomic signature of an avian lilliput effect across the k pg extinction dino killing asteroid s impact on bird evolution new astroglial injury defined biomarkers for neurotrauma assessment new biomarkers can detect concussions even mild ones through simple blood test field study suggests that sex determination in sea lamprey is directly influenced by larval growth rate sex shifting fish growth rate could determine sea lamprey sex grin d recurrent de novo dominant mutation causes a severe epileptic encephalopathy treatable with nmda receptor channel blockers gene discovery in severe epilepsy may offer clues to unique personalized therapies from paper to structured carbon electrodes by inkjet printing electronics comes to paper paper being light and foldable works well for electrically conducting structures direct observation of nonlinear coupling between pedestal modes leading to the onset of edge localized modes fiery sighting a new physics of eruptions that damage fusion experiments a new troodontid theropod talos sampsoni gen. et sp. nov. from the upper cretaceous western interior basin of north america scientists discover rare theropod dinosaur wounded in action in southern utah z scheme solar water splitting via self assembly of photosystem i catalyst hybrids in thylakoid membranes discovery adapts natural membrane to make hydrogen fuel from water a feathered dinosaur tail with primitive plumage trapped in mid cretaceous amber amber specimen offers rare glimpse of feathered dinosaur tail exploring the experience of african immigrant mothers providing reproductive health education to their daughters aged to years for immigrant mothers delivering the talk facts trump culture maternal dietary intakes of refined grains during pregnancy and growth through the first y of life among children born to women with gestational diabetes pregnancy diet high in refined grains could increase kids obesity by age seven effects of deep brain stimulation on rest tremor progression in early stage parkinson disease dbs treatment may slow the progression of parkinson s tremor in early stage patients impact of the experimental removal of lizards on lyme disease risk tick population plummets in absence of lizard hosts increased crop failure due to climate change assessing adaptation options using models and socio economic data for wheat in china crop failures set to increase under climate change time lag to benefit after screening for breast and colorectal cancer meta analysis of survival data from the united states sweden united kingdom and denmark cancer screening unlikely to benefit patients with a short life expectancy less than years and risks are likely to outweigh benefits expected effects of adopting a month regimen for multidrug resistant tuberculosis a population modelling analysis computer model predicts potential impact of short course therapy against multidrug resistant tb migraine and risk of cardiovascular diseases danish population based matched cohort study migraine linked to increased risk of cardiovascular problems true love waits ? a sibling comparison study of age at first sexual intercourse and romantic relationships in young adulthood does true love wait ? age of first sexual experience predicts romantic outcomes in adulthood the apoptotic engulfment machinery regulates axonal degeneration in c. elegans neurons tiny worm opens big discovery on nerve degeneration antigen fixed leukocytes tolerize th responses in mouse models of allergy peanut allergy turned off by tricking immune system new approach makes allergen appear safe and prevents life threatening reaction wild african drosophila melanogaster are seasonal specialists on marula fruit wild african fruit flies offer clues to their modern day domestic life delivering an optimised behavioural intervention obi to people with low back pain with high psychological risk results and lessons learnt from a feasibility randomised controlled trial of contextual cognitive behavioural therapy ccbt vs. physiotherap talking therapy shows promise for people with chronic low back pain defective proviruses rapidly accumulate during acute hiv infection dormant copies of hiv mostly defective new study shows multipotent fetal derived cdx cells from placenta regenerate the heart certain placental stem cells can regenerate heart after heart attack the first brown dwarf discovered by the backyard worlds planet citizen science project new brown dwarf discovered by citizen science project tree ring isotopes capture interannual vegetation productivity dynamics at the biome scale tree rings tell climate stories that technology can t patchy field sampling biases understanding of climate change impacts across the arctic scientists lack vital knowledge on rapid arctic climate change autism and sensory processing disorders shared white matter disruption in sensory pathways but divergent connectivity in social emotional pathways kids with autism and sensory processing disorders show differences in brain wiring restoration of normal bmp signaling levels and osteogenic differentiation in fop mesenchymal progenitor cells by mutant allele specific targeting first proof of principle for treating rare bone disease gucy c opposes systemic genotoxic tumorigenesis by regulating akt dependent intestinal barrier integrity stronger intestinal barrier may prevent cancer in the rest of the body new study suggests playing super mario increases hippocampal grey matter in older adults some video games are good for older adults brains readability suitability and health content assessment of web based patient education materials on colorectal cancer screening website information on colon cancer too complex fails to address key concerns researcher finds complement mediated regulation of the il a axis is a central genetic determinant of the severity of experimental allergic asthma study points to key genetic driver of severe allergic asthma the long term impacts of medicaid exposure in early childhood evidence from the program s origin early childhood exposure to medicaid linked to better adult health study shows plug and display decoration of virus like particles via isopeptide bonds for modular immunization synthetic biologists use bacterial superglue for faster vaccine development influenza vaccination responses in human systemic lupus erythematosus impact of clinical and demographic features african americans with systemic lupus erythematosus more responsive to flu vaccine than patients of european descent effects of future sea level rise on coastal habitat us southeast atlantic coast facing high threat of sea level rise in the next years palovarotene inhibits heterotopic ossification and maintains limb mobility and growth in mice with the humanacvr r hfibrodysplasia ossificans progressiva fop mutation drug candidate stops extra bone growth in animal model of rare genetic disease gas injection may have triggered earthquakes in the cogdell oil field texas gas injection probably triggered small earthquakes near snyder texas an hplc cad fluorescence lipidomics platform using fluorescent fatty acids as metabolic tracers fat metabolism in live fish real time lipid biochemistry observed elective single embryo transfer with cryopreservation improves the cumulative live birth rate diminishes the costs and reduces the multiple pregnancy rate of ivf icsi single embryo transfer is cheapest and most effective strategy for assisted reproduction studies find synergistic effects of influenza and methyl phenyl tetrahydropyridine mptp can be eliminated by the use of influenza therapeutics experimental evidence for multi hit hypothesis infection with seasonal flu may increase risk of developing parkinson s disease the nature of white matter abnormalities in blast related mild traumatic brain injury brain abnormalities found among those experiencing blast related mild traumatic brain injury l sepiapterin restores sle serum induced markers of endothelial function in endothelial cells restoring this enzyme s function protects against heart disease in lupus and beyond the sea cucumber genome provides insights into morphological evolution and visceral regeneration the sea cucumber genome points to genes for tissue regeneration intergenerational associations of parent adverse childhood experiences and child health outcomes trauma from parents youth linked to poorer health asthma in their own children high proportion of smaller ranged hummingbird species coincides with ecological specialization across the americas hummingbirds provide insight into food specialization across the americas feelings matter depression severity and emotion regulation in hiv sti risk related sexual behaviors emotion an important link to hiv prevention in black adolescents with mental illnesses glycolysis optimized conditions enhance maintenance of regenerative integrity in mouse spermatogonial stem cells during long term culture researchers improve technology to save sperm stem cells characterizing nonlocal dispersion compensation in deployed telecommunications fiber photons trained for optical fiber obstacle course will deliver stronger cyber security review of dolichostyrax aurivillius cerambycidae lamiinae in borneo with descriptions of three new genera and the first case of ovo viviparity in the long horned beetles the first long horned beetle giving birth to live young discovered in borneo vocal complexity influences female responses to gelada male calls call of the wild male geladas captivate females with moans yawns a three dimensional movie of structural changes in bacteriorhodopsin from photosynthesis to new compounds for eye diseases cgal a temperature robust gal uas system for caenorhabditis elegans biology s breadboard learning about human nervous system with understanding of worm brain map d and dvl form a feedback loop that facilitates microtubule remodeling and wnt a signaling regulation of cell orientation and shape for tissue morphogenesis matrix metalloproteinase promotes early blood spinal cord barrier disruption and hemorrhage and impairs long term neurological recovery after spinal cord injury presence of enzyme may worsen effects of spinal cord injury and impair long term recovery motorcycle helmets and cervical spine injuries a year experience at a level trauma center helmet use associated with reduced risk of cervical spine injury during motorcycle crashes usefulness of coronary and carotid imaging rather than traditional atherosclerotic risk factors to identify firefighters at increased risk for cardiovascular disease standard assessments miss early signs of cardiovascular disease in firefighters effects of ferric citrate in patients with nondialysis dependent ckd and iron deficiency anemia trial finds oral iron drug safe effective for treating anemia in kidney disease patients gut intraepithelial t cells calibrate metabolism and accelerate cardiovascular disease some gut cells slow down metabolism accelerate cardiovascular disease antarctic last interglacial isotope peak in response to sea ice retreat not ice sheet collapse new antarctic ice discovery aids future climate predictions forage silica and water content control dental surface texture in guinea pigs and provide implications for dietary reconstruction plant phytolith and water content influence rate of tooth enamel abrasion in vertebrates arctic geese tune migration to a warming climate but still suffer from a phenological mismatch in a warming climate arctic geese are rushing north molecular genetic evidence for shared etiology of autism and prodigy autism and prodigy share a common genetic link serum hydroxyvitamin d and breast cancer in the military a case control study utilizing pre diagnostic serum low vitamin d levels linked to high risk of premenopausal breast cancer oral treatment with cuii atsm increases mutant sod in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis findings point toward one of first therapies for lou gehrig s disease lysosomal acid lipase deficiency a new therapy for a genetic lipid disease new enzyme replacement therapy shows promise for genetic lipid disease treatment the current and potential health benefits of the national health service health check cardiovascular disease prevention programme in england a microsimulation study estimating lives saved by england s nhs health check program no longer single ! description of female calumma vatosoa squamata chamaeleonidae including a review of the species and its systematic position single no more first females of a madagascan chameleon described with modern technologies associations between fluorosis of permanent incisors and fluoride intake from infant formula other dietary sources and dentifrice during early childhood substantial consumption of fluoride increases chance of mild fluorosis research finds grik genetically regulated expression associated with eye and vascular phenomes discovery through iteration among biobanks electronic health records and zebrafish study merges big data and zebrafish biology to reveal mechanisms of human disease broad phylogenetic diversity associated with nitrogen loss through sulfur oxidation in a large public marine aquarium motley crews of bacteria cleanse water at huge oceanic georgia aquarium exhibit analyses of pig genomes provide insight into porcine demography and evolution pig genome offers insights into the feistiest of farm animals edoxaban versus warfarin in patients with atrial fibrillation drug effective in preventing stroke reducing bleeding cardiovascular death in patients with atrial fibrillation universal screening of acute medical admissions for excess alcohol consumption what s the misuse ? universal screening for alcohol misuse at hospital admission identifies patients at risk of developing alcoholic liver disease prevalence of population smoking cessation by electronic cigarette use status in a national sample of recent smokers daily e cigarette users had highest rates of quitting smoking analysis of risk factors for central venous port failure in cancer patients what caused implantable venous access device failure in cancer patients ? foxo daf activation slows down turnover of the majority of proteins in c. elegans decelerated protein synthesis degradation in a worm with doubled lifespan glycomacropeptide is a prebiotic that reducesdesulfovibriobacteria increases cecal short chain fatty acids and is anti inflammatory in mice prebiotic dairy protein promotes digestive health holds therapeutic promise the devastating zhouqu storm triggered debris flow of august likely causes and possible trends in a future warming climate storm triggered landslides examining causes of devastating debris flow hidden cost of disease in a free ranging ungulate brucellosis reduces mid winter pregnancy in elk hidden costs of disease to greater yellowstone elk human genealogy reveals a selective advantage to moderate fecundity evolutionary changes played a crucial role in industrialization associations of child and adolescent anxiety with later alcohol use and disorders a systematic review and meta analysis of prospective cohort studies is anxiety in childhood and adolescence linked to later alcohol use disorders ? infectious disease in the ancient aegean intestinal parasitic worms in the neolithic to roman period inhabitants of kea greece ancient feces reveal parasites described in earliest greek medical texts can resistance training impact mri outcomes in relapsing remitting multiple sclerosis ? resistance training may slow down the progression of multiple sclerosis cholesterol biosynthesis inhibitor ro suppresses growth of hormone dependent and castration resistant prostate cancer cells potential cholesterol lowering drug molecule has prostate cancer fighting capabilities room temperature polarized spin photon interface based on a semiconductor nanodisk in nanopillar structure driven by few defects nanoscale pillars as a building block for future information technology identification of clusters of rapid and slow decliners among subjects at risk for alzheimer s disease new data mining strategy spots those at high risk of alzheimer s water fluoridation and dental caries in u.s. children and adolescents water fluoridation confirmed to prevent dental decay in us children and adolescents genomic consequences of intensive inbreeding in an isolated wolf population genome sequencing reveals extensive inbreeding in scandinavian wolves an accreting pulsar with extreme properties drives an ultraluminous x ray source in ngc brightest neutron star yet has a multipolar magnetic field classifying injuries in young children as abusive or accidental reliability and accuracy of an expert panel approach expert panel reliable and accurate in identifying injuries in young children smaller splenium in children with nonverbal learning disability compared to controls high functioning autism and adhd differences in brains of children with nonverbal learning disability microbe associated molecular patterns mamps triggered root responses mediate beneficial rhizobacterial recruitment in arabidopsis. horticultural hijacking the dark side of beneficial soil bacteria early course of nicotine dependence in adolescent smokers adolescent smokers don t recognize early signs of nicotine dependence effect of statin use during hospitalization for intracerebral hemorrhage on mortality and discharge disposition statin use during hospitalization for hemorrhagic stroke associated with improved survival a systems approach reveals urban pollinator hotspots and conservation opportunities cities could play a key role in pollinator conservation glycoprotein iib iiia receptor imaging with f gp pet for acute venous thromboembolism an open label nonrandomized phase study pet ct imaging agent shows promise for better diagnosis of acute venous thromboembolism black hole regulated star formation in massive galaxies supermassive black holes control star formation in large galaxies the fatty acid elongase bond is essential for drosophila sex pheromone synthesis and male fertility bond gene in fruit flies controls fertility of rival males half quantum vortices and walls bounded by strings in the polar distorted phases of topological superfluid he new quantum structures in super chilled helium may mirror early days of universe precise control of hydrogen response of semicontinuous palladium film using piezoelectric resonance method good vibrations using piezoelectricity to ensure hydrogen sensor sensitivity in vivo severity ranking of ras pathway mutations associated with developmental disorders studies point way to precision therapies for common class of genetic disorders atmospheric reconnaissance of the habitable zone earth sized planets orbiting trappist atmospheres of exoplanets in trappist habitable zone probed heterogeneity for igf ii production maintained by public goods dynamics in neuroendocrine pancreatic cancer game theory explains social interactions of cancer cells intra arterial immunoselected cd stem cells for acute ischemic stroke stem cells show promise for stroke in pilot study associations between problems with crying sleeping and or feeding in infancy and long term behavioural outcomes in childhood a meta analysis infants with persistent crying problems more likely to have behavior problems in childhood study finds the current availability of antiepileptic drugs in zambia implications for the ilae who out of the shadows campaign lack of antiepileptic drugs hurts awareness treatment efforts in zambia differentially methylated loci in nafld cirrhosis are associated with key signaling pathways dna methylation related to liver disease among obese patients study shows wireless optofluidic systems for programmable in vivo pharmacology and optogenetics futuristic brain probe allows for wireless control of neurons brain enlargement is associated with regression in preschool age boys with autism spectrum disorders boys with regressive autism but not early onset autism have larger brains than age matched healthy counterparts study finds hyperactivity of newborn pten knock out neurons results from increased excitatory synaptic drive study sheds light on genetic mutations in autism disorders graphene acoustic plasmon resonator for ultrasensitive infrared spectroscopy new graphene based device is first step toward ultrasensitive biosensors low functional redundancy among mammalian browsers in regulating an encroaching shrub solanum campylacanthum in african savannah africa s poison apple provides common ground for saving elephants raising livestock nano encapsulation of arsenic trioxide enhances efficacy against murine lymphoma model while minimizing its impact on ovarian reserve in vitro and in vivo new chemo drug gentler on fertility tougher on cancer association of broad vs narrow spectrum antibiotics with treatment failure adverse events and quality of life in children with acute respiratory tract infections for children with respiratory infections antibiotics with narrower targets are better reversible suppression of an essential gene in adult mice using transgenic rna interference non lethal way of switching off essential genes in mice perfected factors related to making investment mistakes in a down market overconfidence loss aversion are key predictors for investment mistakes the search for environmental causes of parkinson s disease moving forward the search for environmental causes of parkinson s disease moves forward strategic reasoning and bargaining in catastrophic climate change games new light shed on the challenge of climate negotiations individual differences in the effects of music engagement on responses to painful stimulation listening to music can be effective for reducing pain in high anxiety persons successful combination of electron spin resonance luminescence and palaeomagnetic dating methods allows reconstruction of the pleistocene evolution of the lower moulouya river ne morocco river s evolution unfolds with fresh mix of dating techniques a functional magnetic resonance imaging study of spatial working memory in children with prenatal alcohol exposure contribution of familial history of alcohol use disorders family history of alcoholism may add to damaging effects of prenatal alcohol exposure atrazine feminizes sex ratio in blanchard s cricket frogs acris blanchardi at concentrations as low as. g l atrazine alters the sex ratio in blanchard s cricket frogs a dead end host is there a way out ? a position piece on the ebola virus outbreak by the international union of immunology societies the ebola epidemic is there a way out ? assessment of autism symptoms during the neonatal period is there early evidence of autism risk ? preemies at high risk of autism don t show typical signs of disorder in early infancy managerialism and teacher professional identity impact on well being among teachers in the uk managerialism in uk schools erodes teachers mental health and well being triggers for violent criminality in patients with psychotic disorders stressful trigger events associated with risk of violent crime air quality and health benefits from potential coal power plant closures in texas coal power plant regulations neglect a crucial pollutant low dose t replacement restores depressed cardiac t levels preserves coronary microvasculature and attenuate s cardiac dysfunction in experimental diabetes mellitus restoring thyroid hormones in heart may prevent heart disease from diabetes differential strain vulnerability to binge eating behaviors in rats rats frosting helping find genetic causes of binge eating hic links retinoic acid signalling to group innate lymphoid cell dependent regulation of intestinal immunity and homeostasis scientists find molecular link between vitamin a derivative and mouse intestinal health a possible oligosaccharide conjugate vaccine candidate for clostridium difficile is antigenic and immunogenic sweet defence against lethal bacteria synthesizing a potential vaccine candidate for an antibiotic resistant pathogen making the invisible observable by augmented reality in informal science education context augmented reality advances learning especially in informal science education context despite federal legislation shortages of drugs used in acute care settings remain persistent and prolonged shortages in nation s drug supply persist despite federal efforts identification and characterization of a novel zebrafish danio rerio pentraxin carbonic anhydrase the unique pentraxin carbonic anhydrase protein regulates the ability of fish to swim dealing with the unexpected consumer responses to direct accessbrcamutation testing consumers have few negative reactions to the results of genetic testing for cancer mutations study shows synergy between multiple microtubule generating pathways confers robustness to centrosome driven mitotic spindle formation research into fruit fly cells could lead to cancer insights tap is a central transcriptional regulator of airway muticiliogenesis could controlling the p gene be the key to treating chronic lung disease ? photo activated psoralen binds the erbb catalytic kinase domain blocking erbb signaling and triggering tumor cell apoptosis natural compound attacks her positive breast cancer cells neuronal phagocytosis by inflammatory macrophages in als spinal cord inhibition of inflammation by resolvin d how immune system inflammation may play role in lou gehrig s disease neural mechanism for hypothalamic mediated autonomic responses to light during migraine exposure to light causes emotional and physical responses in migraine sufferers coffee consumption is not associated with increased risk of atrial fibrillation results from two prospective cohorts and a meta analysis no link between coffee consumption common type of irregular heartbeat prostaglandin e and programmed cell death signaling coordinately impair ctl function and survival during chronic viral infection combination therapy boosts antiviral response to chronic infection characterisation of retinoblastomas without rb mutations genomic gene expression and clinical studies cancer researchers discover new type of retinoblastoma in babies recreational physical activity and leisure time sitting in relation to postmenopausal breast cancer risk study links moderate activity to lower breast cancer risk matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against mycobacterium tuberculosis cancer drug helps treat tuberculosis by restoring leaky blood vessels amber imitation ? two unusual cases of pinus resin coated beads in iberian late prehistory rd and nd millennia bc first examples of iberian prehistoric imitation amber beads at gravesites the role of adventitious carbon in photo catalytic nitrogen fixation by titania solving a year old mystery might provide a new source of farm fertilizer long chain n polyunsaturated fatty acids and incidence rate of coronary artery calcification in japanese men in japan and white men in the usa population based prospective cohort study high consumption of fish oil may benefit cardiovascular health public health finds opting for families recent trends in the fertility of highly educated women greater numbers of highly educated women are having children bucking recent history neural source filter based waveform model for statistical parametric speech synthesis new method for high speed synthesis of natural voices type i interferons regulate susceptibility to inflammation induced preterm birth study describes potential clinical test and treatment for preterm birth prefrontal cortical dendritic spine pathology in schizophrenia and bipolar disorder schizophrenia bipolar disorder associated with dendritic spine loss in brain widespread seasonal compensation effects of spring warming on northern plant productivity a warmer spring leads to less plant growth in summer feasibility and efficacy of oral rabies vaccine sag in endangered ethiopian wolves first test of oral rabies vaccine brings hope to the world s rarest canid dissociative effects of methylphenidate in nonhuman primates trade offs between cognitive and behavioral performance study pinpoints effects of different doses of an adhd drug finds higher doses may harm learning physical activity modifies genetic susceptibility to obesity in postmenopausal women exercise mitigates genetic effects of obesity later in life combined oral contraceptive use and the risk of systemic lupus erythematosus oral contraceptives associated with increased risk of lupus hepatitis c seroprevalence and hiv co infection in sub saharan africa a systematic review and meta analysis hepatitis c common among hiv positive patients in sub saharan africa dual control of fault intersections on stop start rupture in the central italy seismic sequence research into deadly italian earthquakes could improve future seismic forecasts the dermis as a delivery site of trypanosoma brucei for tsetse flies fluorescent trypanosomes reveal invasion of skin and beyond following tsetse fly bites use and outcomes of triple therapy among older patients with acute myocardial infarction and atrial fibrillation study finds no benefit in adding third drug to therapy for older patients the complement component c a is present in human coronary lesions in vivo and induces the expression of mmp and mmp in human macrophages in vitro new drug target in atherosclerosis anaphylatoxin c a integrated gas hydrate membrane system for natural gas purification a potentially cheap efficient and eco friendly system for purifying natural gas effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency high dose iron pills do not improve exercise capacity for heart failure effects of alcohol tax and price policies on morbidity and mortality a systematic review increasing taxes on alcoholic beverages reduces disease injury crime and death rates study finds uterine artery embolization using a transradial approach initial experience and technique with flip of wrist interventional radiologists treat uterine fibroids the impact of bleeding avoidance strategies on hospital level variation in bleeding rates following percutaneous coronary intervention insights from the national cardiovascular data registry cathpci registry reasons for hospital level variations in bleeding post angioplasty are unclear vaccine elicited receptor binding site antibodies neutralize two new world hemorrhagic fever arenaviruses antibodies against one hemorrhagic fever virus found to disarm a related virus effects of high intensity interval training on fatigue and quality of life in testicular cancer survivors vigorous exercise reduces tiredness in testicular cancer survivors can patient navigation improve receipt of recommended breast cancer care ? evidence from the national patient navigation research program patient navigation may aid in breast cancer treatment in high risk populations effect of autologous cord blood infusion on motor function and brain connectivity in young children with cerebral palsy a randomized placebo controlled trial umbilical cord blood improves motor skills in some children with cerebral palsy atomic description of the immune complex involved in heparin induced thrombocytopenia treatment for heparin induced blood disorder revealed in structure of antibody complex social systems in habitat specialist reef fishes key concepts in evolutionary ecology coral reef fishes prove invaluable in the study of evolutionary ecology the novel asymmetric entry intermediate of a picornavirus captured with nanodiscs first accurate simulation of a virus invading a cell global prevalence of fetal alcohol spectrum disorder among children and youth a systematic review and meta analysis what is the global prevalence of fetal alcohol spectrum disorder ? synovial il tnf producing cd t cells induce joint destruction in rheumatoid arthritis by inducing matrix metalloproteinase production by fibroblast like synoviocytes scientists discover new mechanism that leads to inflammation in rheumatoid arthritis intravenous autologous bone marrow mononuclear cells for ischemic stroke bone marrow stem cell therapy safe for acute stroke study suggests elevated atmospheric concentrations of carbon dioxide reduce monarch tolerance and increase parasite virulence by altering the medicinal properties of milkweeds rising carbon dioxide levels pose a previously unrecognized threat to monarch butterflies mtc labeled small molecule inhibitors of prostate specific membrane antigen pharmacokinetics and biodistribution studies in healthy subjects and patients with metastatic prostate cancer novel molecular imaging drug offers better detection of prostate cancer pick deficiency causes male infertility in mice by disrupting acrosome formation male mice lacking the protein pick mimic one cause of infertility in men a series of kokumi peptides impart the long lasting mouthfulness of matured gouda cheese gooda gouda ! solving the year old secret of a big cheese prenatal maternal smoking and increased risk for tourette syndrome and chronic tic disorders maternal smoking could lead to an increased risk for tourette syndrome tic disorders enterovirus as trigger of coeliac disease nested case control study within prospective birth cohort common virus in early childhood linked to celiac disease in susceptible children waltz of cell membrane coated nanoparticles on lipid bilayers tracking single particle rotation in ligand receptor binding waltzing nanoparticles could advance search for better drug delivery methods a novel stem progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential stem cell scientists discover new airway stem cell outbreak of escherichia coli o associated with raw milk connecticut e. coli outbreak in connecticut caused by raw milk consumption psychotropic drug use among preschool children in the medicaid program from states study finds. percent of preschoolers on medicaid use psychotropic drugs antibiotic prescribing and patient satisfaction in primary care in england cross sectional analysis of national patient survey data and prescribing data frugal antibiotic prescribing associated with lower gp satisfaction scores ror t drives production of the cytokine gm csf in helper t cells which is essential for the effector phase of autoimmune neuroinflammation gm csf required for the immune attack in multiple sclerosis association of type and location ofbrca andbrca mutations with risk of breast and ovarian cancer risk of breast and ovarian cancer may differ by type of brca brca mutation a novel gusb mutation in brazilian terriers with severe skeletal abnormalities defines the disease as mucopolysaccharidosis vii genetic cause of a severe skeletal disease in brazilian terrier puppies revealed structured environments fundamentally alter dynamics and stability of ecological communities when species compete physical structures and ecological relationships matter hepatic ago mediated rna silencing controls energy metabolism linked to ampk activation and obesity associated pathophysiology scientists block rna silencing protein in liver to prevent obesity and diabetes in mice sequential ligand dependent notch signaling activation regulates valve primordium formation and morphogenesis new signaling mechanism implicated in congenital aortic valve disease highly conductive stretchable and biocompatible ag au core sheath nanowire composite for wearable and implantable bioelectronics new soft bioelectronic mesh tested on human wrist and pulsating pig s heart continent sized anomalous zones with low seismic velocity at the base of earth s mantle giant blobs of rock deep inside the earth hold important clues about our planet the hippo transducer taz interacts with the swi snf complex to regulate breast epithelial lineage commitment gene important to breast development breast cancer identified association of childhood pertussis with receipt of doses of pertussis vaccine by time since last vaccine dose california risk of pertussis increases as time since last dose of dtap vaccine lengthens the sodium channel blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis researchers find potential anti cancer use for anti epilepsy drug allosteric inhibition of the ire rnase preserves cell viability and function during endoplasmic reticulum stress new compound treats both blindness diabetes in animal studies individualized venous thromboembolism risk stratification using the caprini score to identify the benefits and harms of chemoprophylaxis in surgical patients standard of care anti clotting drugs may be unnecessary for most surgery patients eigencages learning a latent space of porous cage molecules machine learning research unlocking molecular cages energy saving potential a multiomic approach to characterize the temporal sequence in alzheimer s disease related pathology new brain changes in early alzheimer s disease stem cell quiescence acts as a tumour suppressor in squamous tumours adult stem cells found to suppress cancer while dormant microrna a mediated down regulation of the microglial enriched triggering receptor and phagocytosis sensor trem in age related macular degeneration discovery identifies new treatment target for age releated macular degeneration alzheimer s vacuolar protein degradation via autophagy provides substrates to amino acid catabolic pathways as an adaptive response to sugar starvation in arabidopsis thaliana plants overcome hunger with the aid of autophagy low dose physiological growth hormone in patients with hiv and abdominal fat accumulation a randomized controlled trial growth hormone treatment for hiv patients improves abdominal fat but worsens glucose level a randomized study comparing parathyroidectomy with cinacalcet for treating hypercalcemia in kidney allograft recipients with hyperparathyroidism surgery is more effective than drug in hyperparathyroidism post kidney transplantation the word order of languages predicts native speakers working memory word order predicts a native speakers working memory network structure of brain atrophy in de novo parkinson s disease new study maps the progression of parkinson s disease within the brain oral glucocorticoid sparing effect of benralizumab in severe asthma investigational biologic appears to reduce oral corticosteroid use in severe asthma intracranial meningiomas in individuals under the age of analysis of risk factors histopathology and recurrence rate radiation a risk factor for brain tumors in young people study finds estimation of the maximum annual number of north atlantic tropical cyclones using climate models what is the maximum possible number of atlantic tropical cyclones ? see the year the efficacy of vigorous intensity exercise as an aid to smoking cessation in adults with high anxiety sensitivity exercise helps adults with high anxiety sensitivity quit smoking globin gene transfer to human bone marrow for sickle cell disease stem cell gene therapy for sickle cell disease advances toward clinical trials a pooled analysis of vitamin d dose requirements for fracture prevention higher but not lower doses of vitamin d are effective in fracture risk reduction in older adults study finds hdnetdb a molecular interaction database for network oriented investigations into huntington s disease new data network for huntington s disease research prevalence and correlates of at risk drinking among older adults the project share study high rates of at risk drinking among elderly adults study finds mortality among contraceptive pill users cohort evidence from royal college of general practitioners oral contraception study contraceptive pill not associated with increased long term risk of death study finds the discovery of a natural whale fall in the antarctic deep sea antarctica s first whale skeleton found with nine new deep sea species influenza a virus hemagglutinin glycosylation compensates for antibody escape fitness costs certain flu virus mutations may compensate for fitness costs of other mutations lipoxygenase inhibition reverses cognitive impairment brain amyloidosis and tau pathology by stimulating autophagy in aged triple transgenic mice mouse model points to potential new treatment for alzheimer s disease the use of virtual reality technology in the treatment of anxiety and other psychiatric disorders virtual reality for psychiatric treatment ? research shows promise for vr and other technologies in mental health care relating neuropsychological test performance to cognitive complaints after breast cancer scientific basis for cognitive complaints of breast cancer patients fish can show emotional fever stress induced hyperthermia in zebrafish could fish have consciousness ? emotional fever experiment suggests they might energy drink consumption and increased risk for alcohol dependence energy drink consumption is strongly linked with risks of heavy drinking and alcohol dependence prey patch patterns predict habitat use by top marine predators with diverse foraging strategies bering sea study finds prey density more important to predators than biomass resilience does not explain the dissociation between chronic pain and physical activity in south africans living with hiv despite chronic pain south africans with hiv related pain are surprisingly active activation of gpr a receptor for niacin and the commensal metabolite butyrate suppresses colonic inflammation and carcinogenesis findings bolster fiber s role in colon health dynamics and control of ebola virus transmission in montserrado liberia a mathematical modelling analysis without swift influx of substantial aid ebola epidemic in africa poised to explode a wearable chemical electrophysiological hybrid biosensing system for real time health and fitness monitoring engineers take first step toward flexible wearable biosensor device ocean fronts drive marine fishery production and biogeochemical cycling ocean fronts improve climate and fishery production study finds abcg positivity in tumor buds is an indicator of poor prognosis in node negative colorectal cancer patients a new indicator of poor prognosis in node negative colorectal cancer patients limits to deployment of nuclear power for decarbonization insights from public opinion public dread of nuclear power limits its use filicide mental illness in those who kill their children findings from most in depth study into uk parents who kill their children dioxygenases catalyze o demethylation and o o demethylenation with widespread roles in benzylisoquinoline alkaloid metabolism in opium poppy metabolic enzymes discovered with widespread roles in opium poppy regression of myocardial hypertrophy after aortic valve replacement faster in women ? enlarged hearts in women shrink faster than those in men after aortic valve replacement it s time to regulate the use of whole body electrical stimulation questions over safety of whole body electrical stimulation risk of cardiovascular disease among postmenopausal women with prior pregnancy loss the women s health initiative pregnancy loss cardiovascular disease connected by new study impact of signaling microcompartment geometry on gpcr dynamics in live retinal photoreceptors geometry plays a role in gpcr transmembrane signaling fluorouracil epirubicin and cyclophosphamide fec followed by paclitaxel plus trastuzumab versus paclitaxel plus trastuzumab followed by fec plus trastuzumab as neoadjuvant treatment for patients with her positive breast cancer z a random concurrent therapy not necessary for breast cancer patients with her study says prediction of the export and fate of global ocean net primary production the exports science plan the ocean below scientific plan measures ocean s carbon cycle predicts its future conditions long term safety of pregnancy following breast cancer according to estrogen receptor status pregnancy poses no greater risk to breast cancer survivors low oxygen waters limited habitable space for early animals oxygen levels were key to early animal evolution strongest evidence now shows blood derived cd t cells naturally resist pyroptosis during abortive hiv infection blood t cells are resistant to hiv s primary death pathway improvement of the rett syndrome phenotype in a mecp mouse model upon treatment with levodopa and a dopa decarboxylase inhibitor effective drugs for parkinson s reduce symptoms of rett syndrome in mice soft microfluidic assemblies of sensors circuits and radios for the skin off the shelf on the skin stick on electronic patches for health monitoring the genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish against the tide a fish adapts quickly to lethal levels of pollution msc regulated micrornas converge on the transcription factor foxp and promote breast cancer metastasis silencing the speech gene foxp causes breast cancer cells to metastasize global brain dynamics embed the motor command sequence of caenorhabditis elegans neuroscientists decode the brain activity of the worm branchial nitrogen cycle symbionts can remove ammonia in fish gills new type of symbiosis bacteria eat ammonia in fish gills evolutionary conserved brainstem circuits encode category concentration and mixtures of taste new insights into link between taste and behavior fractal electrodes as a generic interface for stimulating neurons simulations signal early success for fractal based retinal implants an ear dependent regulatory module promotes male germ cell division and sperm fertility in arabidopsis breakthrough study solves plant sex mystery genetic hierarchy in plant sperm cell formation undressed identification of wheat gene sr that confers resistance to ug stem rust race group potential boost for world s food supply resistance gene found against ug wheat stem rust pathogen dendrometer bands made easy using modified cable ties to measure incremental growth of trees new technique for measuring tree growth cuts down on research time synchrotron x ray fluorescence microscopy study of the diffusion of iron manganese potassium and zinc in parboiled rice kernels managing global malnutrition researchers map micronutrients in white rice probable rapid eye movement sleep behavior disorder increases risk for mild cognitive impairment and parkinson disease a population based study rem sleep disorder doubles risk of mild cognitive impairment parkinson s study finds altered amygdala connectivity in individuals with chronic traumatic brain injury and comorbid depressive symptoms brain imaging reveals possible depression signature in traumatic brain injury a assembles into specific barrel pore forming oligomers in membrane mimicking environments new strategy to obtain a specific type of amyloid beta aggregate that may underlie neuronal death in alzheimer s disease recent scientific publications cast doubt on north atlantic right whale future endangered right whale population threatened by entanglements and dramatically declining birth rate change in prevalence of chronic conditions between childhood and adolescence among extremely low birth weight children rate of chronic health problems for low birth weight children does not increase in adolescence the ethics of fertility preservation for pediatric patients with differences disorders of sex development is fertility preservation right for children with differences of sex development ? short term effects of great cormorant droppings on water quality and microbial community of an artificial agricultural reservoir when birds of a feather poop together excessive birds feces and algal blooms the evolution of drug resistance in clinical isolates ofcandida albicans new insights into the genetics of drug resistant fungal infections cosmic bell test using random measurement settings from high redshift quasars light from ancient quasars helps confirm quantum entanglement gut microbiota and human health insights from ecological restoration biologist advocates ecological approach to improving human health validating the concept of mutational signatures with isogenic cell models tracing the footprints of a tumor genomic scars allow cancer profiling angptl deficiency and protection against coronary artery disease genetic errors associated with heart health may guide drug development long acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early stage alzheimer s disease dementia nasal spray with insulin equivalent shows promise as treatment for adults with mild cognitive impairment alzheimer s dementia gravitropism interferes with hydrotropism via counteracting auxin dynamics in cucumber roots clinorotation and spaceflight experiments cucumbers in space provide insights on root growth selective and membrane permeable small molecule inhibitors of nicotinamide n methyltransferase reverse high fat diet induced obesity in mice promising anti obesity drug shrinks fat without suppressing appetite restoration of sensitivity in chemo resistant glioma cells by cold atmospheric plasma cold plasma successful against brain cancer cells study suggests quantifying climate sensitivity and climate driven change in north american amphibian communities climate change not main driver of amphibian decline paris thin a call to regulate life threatening starvation of runway models in the us fashion industry call to regulate starvation of paris thin models why lifespans are more variable among blacks than among whites in the united states why lifespans are more variable among blacks than whites in the u.s. therapeutic targeting of bet bromodomain proteins in castration resistant prostate cancer new target for prostate cancer resistant to anti hormone therapies declining use of radiotherapy for adverse features after radical prostatectomy results from the national cancer data base use of radiotherapy after prostate cancer surgery declining despite evidence of benefit risk factors for osteonecrosis of the jaws a case control study from the condor dental pbrn experts release large studies on osteonecrosis of the jaw a novel noninvasive predictive epilepsy biomarker with clinical potential animal study unveils predictive marker for epilepsy development following febrile seizure atrial arrhythmias after lung transplantation incidence and risk factors in lung transplant recipients researchers shine light on common heart complication after lung transplantation evolutionary history resolves global organization of root functional traits theory suggests root efficiency independence drove global spread of flora mortality from diseases conditions and injuries where alcohol is a necessary cause in the americas alcohol consumption is a necessary cause of nearly deaths per year in the americas study finds gut and blood differ in constitutive blocks to hiv transcription suggesting tissue specific differences in the mechanisms that govern hiv latency hiv latency differs across tissues in the body a complete catalogue of high quality topological materials good news for future tech exotic topological materials are surprisingly common following suit using conversation cards for priority setting in pediatric weight management conversation cards a useful tool in pediatric weight management a multilevel analysis of the relationship between parental migration and left behind children s macronutrient intakes in rural china rising risk of obesity among china s left behind children innovative self regulation strategies to reduce weight gain in young adults national study shows new ways to stop weight gain cut young adults obesity risk by half inter annual and decadal changes in teleconnections drive continental scale synchronization of tree reproduction north atlantic oscillation synchronizes tree reproduction across europe comprehensive analysis of dengue virus specific responses supports an hla linked protective role for cd t cells surprising finding could alter the face of dengue vaccine development envelope residue substitutions in simian human immunodeficiency viruses enhance cd binding and replication in rhesus macaques better animal model to improve hiv vaccine development impact of smoking ban on passive smoke exposure in pregnant non smokers in the southeastern united states pregnant women in nc exposed to less secondhand nicotine after smoking ban direct benefit of vaccinating boys along with girls against oncogenic human papillomavirus bayesian evidence synthesis men benefit from vaccinating girls against hpv but remain at risk of some cancers dna methylation outliers in normal breast tissue identify field defects that are enriched in cancer vital clues to future cancer development in normal breast tissue dna the social environment and suicide attempts in lesbian gay and bisexual youth study links social environment to high attempted suicide rates among gay youth association of prescribed opioids with increased risk of community acquired pneumonia among patients with and without hiv prescribed opioids raise risk of pneumonia in patients with and without hiv exosomes secreted by nematode parasites transfer small rnas to mammalian cells and modulate innate immunity trojan horse tactic gives parasites edge over immune systems scai acc hfsa sts clinical expert consensus statement on the use of percutaneous mechanical circulatory support devices in cardiovascular care new guidance on use of heart pumps released by leading cardiovascular societies human papillomavirus genotype distributions implications for vaccination and cancer screening in the united states human papillomavirus genotype distribution in new mexico cervical cancers long haul optical transmission link using low noise phase sensitive amplifiers fibre optic transmission of km made possible by ultra low noise optical amplifiers strategies for network gwas evaluated using classroom crowd science classroom crowdscience students challenged to detect schizophrenia genes does shortening the school week impact student performance ? evidence from the four day school week four day school week can improve academic performance study finds hypothalamic agrp neurons control peripheral substrate utilization and nutrient partitioning brain neurons and diet influence onset of obesity and diabetes in mice retinal vessel caliber and lifelong neuropsychological functioning retinal imaging as an investigative tool for cognitive epidemiology blood vessels in the eye linked with iq cognitive function maternal prenatal iron status and tissue organization in the neonatal brain prenatal maternal iron intake shown to affect the neonatal brain common genetic variants and risk of brain injury after preterm birth genes play key role in brain injury risk for premature babies age of first exposure to football and later life cognitive impairment in former nfl players former nfl players who played tackle football before age at increased risk of memory thinking problems later detection of unamplified target genes via crispr cas immobilized on a graphene field effect transistor crispr chip enables digital detection of dna without amplification immigrants at the mississippian polity of cahokia strontium isotope evidence for population movement native american city on the mississippi was america s first melting pot comparison of the value of nursing work environments in hospitals across different levels of patient risk lower surgical mortality in hospitals with best nursing care novel study shows broad diversity of neutralizing antibodies isolated from memory b cells in hiv infected individuals new technology opens gateway to studying hiv specific neutralizing antibodies a latitudinally banded phytoplankton response to st century climate change in the southern ocean across the cmip model suite tiny phytoplankton have big influence on climate change immunogenicity and reactogenicity of alternative schedules of hpv vaccine in vietnam a cluster randomized noninferiority trial lengthening dosing schedule of hpv vaccine may provide effective option for expanding use of vaccine reduction of common cold symptoms by encapsulated juice powder concentrate of fruits and vegetables a randomised double blind placebo controlled trial fruit and vegetable concentrate decreases number of days with severe cold symptoms life in a fishbowl prospects for the endangered devils hole pupfish cyprinodon diabolis in a changing climate climate change puts endangered devils hole pupfish at risk of extinction the appropriateness of more intensive colonoscopy screening than recommended in medicare beneficiaries older patients with limited life expectancy still receiving cancer screenings genome wide association study reveals multiple loci associated with primary tooth development during infancy late baby teeth may mean more orthodontic visits genes associated with early tooth development identified development of amygdala functional connectivity during infancy and its relationship with year behavioral outcomes brain circuits for successful emotional development established during infancy dried blood spot real time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infection traditional heel stick test is not an effective screening tool for cmv in newborns remote sensing of ground deformation for monitoring groundwater management practices application to the santa clara valley during the california drought scientists monitor silicon valley s underground water reserves from space a novel approach to modelling transcriptional heterogeneity identifies the oncogene candidate cbx in invasive breast carcinoma new gene hunt reveals potential breast cancer treatment target repeat bleaching of a central pacific coral reef over the past six decades study tracks severe bleaching events on a pacific coral reef over past century cacao polyphenols influence the regulation of apolipoprotein in hepg and caco cells new explanation for heart healthy benefits of chocolate comparative genomics identifies epidermal proteins associated with the evolution of the turtle shell similar proteins protect the skin of humans turtles new strategies are needed to stop overdose fatalities the case for supervised injection facilities to reduce overdose deaths us needs to pilot the use of supervised injection facilities a non bipartite propensity score analysis of the effects of teacher student relationships on adolescent problem and prosocial behavior positive teacher student relationships boost good behavior in teenagers for up to years cytokinin induces genome wide binding of the type b response regulator arr to regulate growth and development in arabidopsis greater understanding of plant hormone results in stem cells that grow shoots body size downgrading of mammals over the late quaternary unprecedented wave of large mammal extinctions linked to prehistoric humans prokaryotic diversity and biogeochemical characteristics of benthic microbial ecosystems at la brava a hypersaline lake at salar de atacama chile microbial ecosystem at laguna la brava may contain novel microorganisms baby gate related injuries among children in the united states number of children treated in u. s. emergency departments for baby gate related injuries nearly quadrupled since structures of archaeal dna segregation machinery reveal bacterial and eukaryotic linkages scientists unlock secrets of a heat loving microbe fitness landscape of the human immunodeficiency virus envelope protein that is targeted by antibodies big data methods learn the fitness landscape of the hiv envelope protein from the cover spiny frogs paini illuminate the history of the himalayan region and southeast asia frogs evolution tracks rise of himalayas and rearrangement of southeast asia monoclonal antibodies for emerging infectious diseases borrowing from history for nanomedicine cell sex matmonoclonal antibodies crucial to fighting emerging infectious diseases metabotropic glutamate receptor is a coreceptor for alzheimer a oligomer bound to cellular prion protein alzheimer s missing link found promising target for new drugs patterned and functionalized nanofiber scaffolds in three dimensional hydrogel constructs enhance neurite outgrowth and directional control d neural structure guided with biocompatible nanofiber scaffolds and hydrogels does a scientific breakthrough increase confidence in science ? news of a zika vaccine and trust in science public trust in science spiked after media coverage of zika vaccine trial successful conservation of global waterbird populations depends on effective governance political instability and weak governance lead to loss of species study finds perspective taking abilities in the balance between autism tendencies and psychosis proneness perspective taking difficulties diminished when autistic and psychosis tendencies balance a framework to assess national level vulnerability from the perspective of food security the case of coral reef fisheries corals and food security study shows nations at risk can we build an efficient response to the prescription drug abuse epidemic ? assessing the cost effectiveness of universal prevention in the prosper trial in fight against teen prescription drug abuse home and school based programs work in combination potential protective effect of biphasic electrical stimulation against growth factor deprived apoptosis on olfactory bulb neural progenitor cells through the brain derived neurotrophic factor phosphatidylinositol kinase akt pathway biphasic electrical stimulation a strategy may bring hope to spinal cord injury patients first trimester plasma glucose values in women without diabetes are associated with risk for congenital heart disease in offspring higher blood sugar in early pregnancy raises baby s heart defect risk static dental disparity and morphological turnover in sharks across the end cretaceous mass extinction the end cretaceous extinction unleashed modern shark diversity crispr enhanced engineering of therapy sensitive cancer cells for self targeting of primary and metastatic tumors engineered cancer cells can fight primary and metastatic cancer the genome and development dependent transcriptomes of pyronema confluens a window into fungal evolution gap closed in the genetic map of fungi research team sequences genome of pyronema confluens a single crispr cas deletion strategy that targets the majority of dmd patients restores dystrophin function in hipsc derived muscle cells stem cell gene therapy could be key to treating duchenne muscular dystrophy translational control of lipogenic enzymes in the cell cycle of synchronous growing yeast cells study finds new target for controlling cell division multi level proteomics identifies ct as a chemosensitivity mediator and immunotherapy target in ovarian cancer novel biomarker found in ovarian cancer patients can predict response to therapy pik ca mutations enable targeting of a breast tumor dependency through mtor mediated mcl translation common breast cancer mutation could be vulnerable to drug combination performance and validation of the u.s. ncdr acute kidney injury prediction model in japan us prediction models for kidney injury following angioplasty hold up in japan prediction of the incidence recurrence and persistence of atopic dermatitis in adolescence a prospective cohort study choice of career is a major risk factor for persistent neurodermatitis interpretation and use of frax in clinical practice new review clarifies the use of frax in clinical practice direct observations of evolving subglacial drainage beneath the greenland ice sheet evolving plumbing system beneath greenland slows ice sheet as summer progresses the relationship between exposure to brand specific alcohol advertising and brand specific consumption among underage drinkers united states alcohol ads linked to teen alcohol brand choices dynamic illumination of spatially restricted or large brain volumes via a single tapered optical fiber new adjustable optical microprobe for the analysis and control of deep brain regions influence of previous radiation exposure on pathologic features and clinical outcome in patients with thyroid cancer radiation exposure associated with more aggressive thyroid cancer worse outcomes stable isotope studies reveal pathways for the incorporation of non essential amino acids in acyrthosiphon pisum pea aphids aphids balance their diets by rebuilding plant amino acids prophylactic antibiotics in the prevention of infection after operative vaginal delivery anode a multicentre randomised controlled trial preventative antibiotics after assisted childbirth almost halve maternal infection rate and reduce overall antibiotic use highly conductive carbon nanotube matrix accelerates developmental chloride extrusion in central nervous system neurons by increased expression of chloride transporter kcc carbon nanotubes lower nerve damaging chloride in cells radiocesium in migratory aquatic game birds using contaminated u.s. department of energy reactor cooling reservoirs a long term perspective aquatic rest stops may pose potential hazards for migratory waterfowl human cancer antigen globo h is a cell surface ligand for human ribonuclease cancer discovery links experimental vaccine and biological treatment biomechanical consequences of running with deep core muscle weakness study uncovers potential key to preventing back pain in runners chronic kidney disease of unknown cause in agricultural communities chronic kidney disease epidemic in agricultural workers high heat toxins misuse of stimulant medication among college students a comprehensive review and meta analysis one in six college students misuse adhd stimulant drugs neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of lafora disease link between abnormal sugar accumulation and the neuronal degeneration characteristic of lafora disease mutant ataxin disrupts cerebellar development in spinocerebellar ataxia type adult onset neurodegeneration has roots in early development the effect of the composition of pla films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche a step towards repairing the central nervous system automated whole cell patch clamp electrophysiology of neurons in vivo robot reveals the inner workings of brain cells automated way to record electrical activity inside neurons in the living brain detection of zika virus using reverse transcription lamp coupled with reverse dot blot analysis in saliva researchers adapt hiv test in developing rapid diagnostic test for zika virus chronic ethanol feeding increases the severity of staphylococcus aureus skin infections by altering local host defenses restoring il may treat skin infections related to chronic alcohol consumption age dependent germline mosaicism of the most common noonan syndrome mutation shows the signature of germline selection common genetic disease linked to father s age novel plant immune priming compounds identified via high throughput chemical screening target salicylic acid glucosyltransferases in arabidopsis screening technique uncovers five new plant activator compounds the dynamics of kelp forests in the northeast pacific ocean and the relationship with environmental drivers world war i era maps help track history of kelp forests in pacific northwest magnetism in two dimensional van der waals materials d magnetism atom thick platforms for energy information and computing research measurement of perceived stress in age related macular degeneration assessing the impact of stress in age related macular degeneration psychostimulant use and fatal stroke in young adults psychostimulants play a major role in fatal strokes among young adults relationships between lake level changes and water and salt budgets in the dead sea during extreme aridities in the eastern mediterranean under the dead sea warnings of dire drought is caffeine a good scavenger of oxygenated free radicals ? new evidence that caffeine is a healthful antioxidant in coffee long term outcome of children diagnosed with pediatric low grade gliomas an analysis of the surveillance epidemiology and end results seer database long term survival among patients with most common childhood brain tumor is high lower if treatment included radiation eeg complexity as a biomarker for autism spectrum disorder risk using eegs to diagnose autism spectrum disorders in infants machine learning system finds differences in brain connectivity changes in intake of protein foods carbohydrate amount and quality and long term weight change results from prospective cohorts choice of protein and carbohydrate rich foods may have big effects on long term weight gain dispersals and genetic adaptation of bantu speaking populations in africa and north america the genetic history of bantu speakers and their relationship to african americans dairy in adulthood from foods to nutrient interactions on bone and skeletal muscle health the role of dairy in maintaining adult bone and skeletal muscle health integrated population modeling provides the first empirical estimates of vital rates and abundance for polar bears in the chukchi sea first tally of us russia polar bears finds a healthy population teaching neuraxial anesthesia techniques for obstetric care in a ghanaian referral hospital labor analgesia in low income countries experience from ghana low photon count phase retrieval using deep learning deep learning technique reveals invisible objects in the dark narrowing the treatment gap in managing opioid use disorder new national guideline sets out best practices for treating opioid addiction temperature impacts on economic growth warrant stringent mitigation policy estimated social cost of climate change not accurate scientists say the top fungal pathogens in molecular plant pathology scientists create top ten list of plant damaging fungi the live attenuated dengue vaccine tv elicits complete protection against dengue in a human challenge model experimental dengue vaccine protects all recipients in virus challenge study the risk of death by age sex and smoking status in the united states putting health risks in context risk of death charts by age and gender updated ethical alternatives to experiments with novel potential pandemic pathogens experiments using virulent avian flu strains pose risk of accidental release life history responses of meerkats to seasonal changes in extreme environments fate of meerkats tied to seasonal climate effects acth protects against glucocorticoid induced osteonecrosis of bone potential treatment for bone death in the hip from osteonecrosis calcium channel blocker reduces airway remodeling in severe asthma a proof of concept study severe asthma gallopamil confirmed as a therapeutic approach publication metrics and success on the academic job market success for scientists in the academic job market is highly predictable complete surgical excision is essential for the management of patients with breast implant associated anaplastic large cell lymphoma complete surgical excision is the most effective treatment for breast implant associated anaplastic large cell lymphoma impaired amino acid transport at the blood brain barrier is a cause of autism spectrum disorder autism spectrum disorders new genetic cause of identified composition of human skin microbiota affects attractiveness to malaria mosquitoes microbial communities on skin affect humans attractiveness to mosquitoes incorporating phase change materials in concrete pavement to melt snow and ice wax on melt off adding phase change materials like paraffin to concrete could make roads that melt snow and ice arsenic promotes nf b mediated fibroblast dysfunction and matrix remodeling to impair muscle stem cell function chronic arsenic exposure can impair ability of muscle to heal after injury host microbe interactions have shaped the genetic architecture of inflammatory bowel disease new genetic links for inflammatory bowel disease uncovered resilience of marine turtle regional management units to climate change nesting site protection key to save turtles from climate change laparoscopic total pancreatectomy with islet autotransplantation and intraoperative islet separation as a treatment for patients with chronic pancreatitis success with first patients undergoing minimally invasive pancreatic transplant surgery single cell rna seq reveals cellular heterogeneity of pluripotency transition and x chromosome dynamics during early mouse development molecular puzzle reveals unknown stages of fetal development first genome wide association study of latent autoimmune diabetes in adults reveals novel insights linking immune and metabolic diabetes first gwas analysis of type. diabetes reveals links between immune and metabolic disease aerobic fitness hippocampal viscoelasticity and relational memory performance firmer fitter frame linked to firmer fitter brain portable optical fiber probe for in vivo brain temperature measurements new probe developed for improved high resolution measurement of brain temperature pathology of congenital zika syndrome in brazil a case series zika virus identified in brain placenta tissue strengthening link to birth defects skeletal plasticity in response to embryonic muscular activity underlies the development and evolution of the perching digit of birds dinosaur like lower leg created on bird through molecular experiment safety and immunogenicity of as b adjuvanted split virion versus non adjuvanted whole virion h n influenza vaccine in uk children aged months years open label randomised parallel group multicentre study young children respond well to recommended swine flu vaccine study suggests intensifying drought eliminates the expected benefits of elevated carbon dioxide for soybean future drought will offset benefits of higher co on soybean yields p c s protects a rat model of alzheimer s disease from neuropsychiatric deficits and neurodegeneration without altering amyloid deposition or reactive glia saving neurons may offer new approach for treating alzheimer s disease measles mumps and rubella titers in air force recruits recruits show lower immunity levels to measles mumps rubella loss of cd mediated actin polymerization promotes endometrial tumor progression loss of enzyme promotes tumor progression in endometrial cancer noninvasive transorbital alternating current stimulation improves subjective visual functioning and vision related quality of life in optic neuropathy noninvasive current stimulation improves sight in patients with optic nerve damage study suggests colloids versus crystalloids for fluid resuscitation in critically ill patients iv fluids used by nhs responsible for unnecessary deaths review finds immunodeficiency and risk of myocardial infarction among hiv positive individuals with access to care no increased risk for heart attacks among hiv positive patients with high cd cell count car t cells targeting b h a pan cancer antigen demonstrate potent preclinical activity against pediatric solid tumors and brain tumors engineered immune cells target broad range of pediatric solid tumors in mice living with melanoma for a day a phenomenological analysis of medical students simulated experiences doctors gain a greater understanding of skin cancer using tattoos variations in orai gene associated with kawasaki disease genetic variation may explain asian susceptibility to kawasaki disease depression in type diabetes was associated with high levels of circulating galectin new link identified between inflammation and depression in type diabetes topoisomerases facilitate transcription of long genes linked to autism a potential cause of autism ? key enzymes are found to have a profound effect across dozens of genes linked to autism vitamin d deficiency is associated with an increased likelihood of incident depression in community dwelling older adults study links vitamin d deficient older adults with greater risk of developing depression changes in testing for human immunodeficiency virus sexually transmitted infections and hepatitis c virus in opioid treatment programs proportion of opioid treatment programs offering on site testing for hiv stis declines hematopoietic stem cell transplantation in patients with gain of function stat mutation world first stem cell treatment for lethal stat gene mutation shows disappointing but promising results feasibility of a critical care ultrasound curriculum delivered through a social media platform facebook facebook viable method for implementing critical care ultrasound curriculum relaxation compensated amide proton transfer apt mri signal intensity is associated with survival and progression in high grade glioma patients protein content as a marker for response to therapy in brain cancer effects of swim training on liver carcinogenesis in male wistar rats fed a low fat or high fat diet swim training plus healthy diet factor in cancer fight il rap potentiates multiple oncogenic signaling pathways in aml single surface protein boosts multiple oncogenic pathways in acute myeloid leukemia perinatal outcomes among women with bipolar disorder a population based cohort study women with bipolar disorder at percent greater risk of delivering preterm babies quantitative tissue tracking cardiac magnetic resonance cmr of left atrial deformation and the risk of stroke in patients with atrial fibrillation motion tracking mri tests reveal novel harbingers of stroke in people with common heart rhythm disorder targeting rna foci reduces pathology in ipsc derived motor neurons from c orf repeat patients. lou gehrig s disease from patient stem cells to potential treatment strategy a genome editing strategy to treat hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition crispr gene editing reveals new therapeutic approach for blood disorders optimal targeting of seasonal influenza vaccination toward younger ages is robust to parameter uncertainty flu vaccines aimed at younger populations could break annual transmission cycle universal or specific ? a modeling based comparison of broad spectrum influenza vaccines against conventional strain matched vaccines key benefits of large scale use of universal over conventional flu vaccines cdk but not cdk is the sole cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes discovery of a molecule that initiates maturation of mammalian eggs can lead to more ivf pregnancies m a rna modification controls cell fate transition in mammalian embryonic stem cells loss of a chemical tag on rna keeps embryonic stem cells in suspended animation bedtime in preschool aged children and risk for adolescent obesity early preschool bedtimes cut risk of obesity later on vitamin d deficiency its role in health and disease and current supplementation recommendations widespread vitamin d deficiency likely due to sunscreen use increase of chronic diseases review finds chromatin signaling to kinetochores transregulation of dam methylation by histone h b ubiquitination scientists discover secret life of chromatin dna histone combination a destination for cell signals also talks to other proteins kidney targeted inhibition of protein kinase c ameliorates nephrotoxic nephritis with restoration of mitochondrial dysfunction inflammation inhibitor delivered directly to kidneys reverses course of destructive nephritis identification of four new susceptibility loci for testicular germ cell tumour genetic testing could identify men at a fold increased risk of testicular cancer incident hiv during pregnancy and postpartum and risk of mother to child hiv transmission a systematic review and meta analysis risk of hiv infection high during pregnancy the postpartum period very long chain tear film lipids produced by fatty acid elongase elovl prevent dry eye disease in mice very long chain lipids could help prevent dry eye disease mechanisms of chronic muscle wasting and dysfunction after an intensive care unit stay a pilot study many icu patients trade critical illness for new illness icu acquired weakness hemispheric sea ice distribution sets the glacial tempo earth s orbital variations sea ice synch glacial periods apolipoprotein e apoe genotype is associated with elevated psychiatric distress in veterans with a history of mild to moderate traumatic brain injury gene variant may increase psychiatric risk after traumatic brain injury thresholds in marsh resilience to the deepwater horizon oil spill deepwater horizon oil spill caused widespread marsh erosion study shows histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of kabuki syndrome drug treats inherited form of intellectual disability in mice impact of psychological factors on subjective disease activity assessments in patients with severe rheumatoid arthritis depression higher than previously reported in people with severe rheumatoid arthritis metagenomic sequencing of hpv negative condylomas detects novel putative hpv types hidden strains of hpv found in virus negative genital warts randomized intervention trial to decrease bisphenol a urine concentrations in women pilot study reducing exposure to bisphenol a bpa lowers levels of this environmental estrogen in women improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition fecal transplant success for diabetes might depend on the recipient s gut microbes does money make people right wing and inegalitarian a longitudinal study of lottery wins money makes people right wing inegalitarian uk study finds hormonal contraceptives for contraception in overweight or obese women hormonal contraceptives have mixed success among overweight women a live impaired fidelity coronavirus vaccine protects in an aged immunocompromised mouse model of lethal disease new live vaccine approach for sars and novel coronaviruses discovered adaptation potential of european agriculture in response to climate change european farmers importance of adapting to climate change rna cytosine methylation and methyltransferases mediate chromatin organization and azacytidine response and resistance in leukaemia probing rna epigenetics and chromatin structures to predict drug resistance in leukemia risk factors for first venous thromboembolism around pregnancy a population based cohort study from the united kingdom stillbirth or pre term birth outcomes linked to elevated risk of blood clots after pregnancy long term viability and function of transplanted islets macroencapsulated at high density are achieved by enhanced oxygen supply implantable islet cells come with their own oxygen supply association between breakfast consumption and educational outcomes in year old children study provides strongest evidence yet of a link between breakfast quality and educational outcomes outcomes among older patients receiving implantable cardioverter defibrillators for secondary prevention study finds high survival rate for elderly patients with implantable defibrillator sox messenger cells orchestrate large scale skeletal regeneration in the mammalian rib messenger cells bring good news for bone healing longitudinal effects of prenatal exposure to air pollutants on self regulatory capacities and social competence prenatal exposure to air pollution linked to impulsivity emotional problems in children insect resistance to bt crops lessons from the first billion acres biotech crops vs. pests successes and failures from the first billion acres arix a randomised trial of acupuncture v oral care sessions in patients with chronic xerostomia following treatment of head and neck cancer acupuncture relieves symptoms of a dry mouth caused by radiotherapy for head and neck cancers study suggests dysfunctions of the basal ganglia cerebellar thalamo cortical system produce motor tics in tourette syndrome brain s role in tourette tics simulated in new computational model obesity and overweight problems among individuals to years following acute rehabilitation for traumatic brain injury obesity and overweight linked to long term health problems after traumatic brain injury earth s youngest banded iron formation implies ferruginous conditions in the early cambrian ocean scientists discover earth s youngest banded iron formation in western china early functional impairment of sensory motor connectivity in a mouse model of spinal muscular atrophy communication breakdown early defects in sensory synapses in motor neuron disease real time intravital imaging of ph variation associated with osteoclast activity real time visualization of the function of bone resorbing cells within animals head and neck cancer among lifelong never smokers and ever smokers never smokers fare far better than smokers after radiation therapy for head and neck cancer the role of selection in shaping diversity of natural m. tuberculosis populations tuberculosis genomes portray secrets of pathogen s success new and appropriate goals for parkinson disease physical therapy aerobic exercise benefits patients with parkinson s disease genome wide linkage analyses identify hfhl and hfhl with frequency specific effects on the hearing spectrum of nih swiss mice novel genetic loci identified for high frequency hearing loss right shift for non speech motor processing in adults who stutter profound reorganization in brains of adults who stutter auditory motor integration located in different part of brain topical neutralization of interleukin during experimental pseudomonas aeruginosa corneal infection promotes bacterial clearance and reduces pathology antibodies to immune cells protect eyes in pseudomonas infection thyroid function tests and mortality in aged hospitalized patients a year prospective observational study low thyroid levels may signal heightened risk of death in hospitalized patients journal club molecular breast imaging at reduced radiation dose for supplemental screening in mammographically dense breasts new breast exam nearly quadruples detection of invasive breast cancers in women with dense breast tissue the effect of sit stand desks on office worker behavioral and health outcomes a scoping review the ups and downs of sit stand desks factors associated with sleep in family caregivers of individuals with dementia nine out of people caring for a family member with dementia don t get enough sleep combined blockade of the histamine h and h receptor suppresses peanut induced intestinal anaphylaxis by regulating dendritic cell function blockade of histamine receptors suppresses intestinal anaphylaxis in peanut allergy molecular microcircuitry underlies functional specification in a basal ganglia circuit dedicated to vocal learning scientists id genes in zebra finch brain linked to singing may teach us about human speech disorders endemic endangered and evolutionarily significant cryptic lineages in seychelles frogs anura sooglossidae conservationists discover hidden diversity in ancient frog family tracking an atmospheric river in a warmer climate from water vapor to economic impacts from property damage to lost production how natural disasters impact economics skin cancer precursor immunotherapy for squamous cell carcinoma prevention immunotherapy of precancerous skin lesions may prevent squamous cell carcinoma administration of influenza vaccines to egg allergic recipients a practice parameter update guidelines say no special precautions needed for flu shots for people allergic to eggs developmental trajectories for visuo spatial attention are altered by prenatal alcohol exposure a longitudinal fmri study prenatal alcohol exposure alters development of brain function neural basis for symptoms of fetal alcohol spectrum disorders a national study of the impact of rapid influenza testing on clinical care in the emergency department rapid testing to diagnose flu leads to more appropriate care in ed a ceratopsian dinosaur from the late cretaceous of eastern north america and implications for dinosaur biogeography rare fossil of a horned dinosaur found from lost continent electric fields control the orientation of peptides irreversibly immobilized on radical functionalized surfaces implantable medical devices bolstered by next gen surface modification a year record of east asian monsoon rainfall from be in loess dusty rainfall records reveal new understanding of earth s long term climate a patient level calibration framework for evaluating surveillance strategies a case study of mammographic follow up after early breast cancer new model of follow up for breast cancer patients incident hepatitis b virus infection in hiv infected and hiv uninfected men who have sex with men from pre haart to haart periods a cohort study hiv drugs provide added benefit of protecting against hepatitis b virus infants born preterm compared with infants born full term blood flow altered in brains of preterm newborns vs. full term infants dietary plasticity of generalist and specialist ungulates in the namibian desert a stable isotopes approach eating poisonous plants saves life of gemsbok in namibian desert swimming muscles power suction feeding in largemouth bass bass use body s swimming muscles to suck in food human microbiota secreted factors inhibit shiga toxin synthesis by enterohemorrhagic escherichia coli o h normal human gut bacteria may inhibit shiga toxin development following infection with e. coli o h carry over effects on the annual cycle of a migratory seabird an experimental study devotion to rearing chicks can come at a cost for migratory birds health outcomes of school aged children conceived using donor sperm children conceived using donor sperm have similar health and well being to general population maryland alcohol sales tax and sexually transmitted infections maryland s alcohol sales tax reduced alcohol sales study suggests inhibition of pluripotency networks by the rb tumor suppressor restricts reprogramming and tumorigenesis tumor suppressor also inhibits key property of stem cells researchers say hedgehog signaling regulates brain tumor stem cell self renewal and portends shorter survival for patients with pten coexpressing glioblastomas mechanism in cells that generate malignant brain tumors may offer target for gene therapy